Manoj Puthia, Jitka Petrlova, Ganna Petruk, Marta Butrym, Firdaus Samsudin, Madelene Å Andersson, Ann-Charlotte Strömdahl, Sebastian Wasserstrom, Erik Hartman, Sven Kjellström, Lucrezia Caselli, Oxana Klementieva, Peter J Bond, Martin Malmsten, Deepak Bushan Raina, Artur Schmidtchen
Surgical site infections (SSI) are a clinical and economic burden. Suture-associated SSI may develop when bacteria colonize the suture surface and form biofilms that are resistant to antibiotics. Thrombin-derived C-terminal peptide (TCP)-25 is a host defense peptide with a unique dual mode of action that can target both bacteria and the excessive inflammation induced by bacterial products. The peptide has demonstrated therapeutic potential in preclinical in vivo wound infection models. In this study, we set out to explore whether TCP-25 could provide a new bioactive innate immune feature to hydrophilic polyglactin sutures (Vicryl)...
September 9, 2023: Advanced Healthcare Materials