Ozlem Bulut, Godfrey S Temba, Valerie A C M Koeken, Simone J C F M Moorlag, L Charlotte J de Bree, Vera P Mourits, Vesla I Kullaya, Martin Jaeger, Cancan Qi, Niels P Riksen, Jorge Domínguez-Andrés, Cheng-Jian Xu, Leo A B Joosten, Yang Li, Quirijn de Mast, Mihai G Netea
In old age, impaired immunity causes high susceptibility to infections and cancer, higher morbidity and mortality, and poorer vaccination efficiency. Many factors, such as genetics, diet, and lifestyle, impact aging. This study aimed to investigate how immune responses change with age in healthy Dutch and Tanzanian individuals and identify common metabolites associated with an aged immune profile. We performed untargeted metabolomics from plasma to identify age-associated metabolites, and we correlated their concentrations with ex-vivo cytokine production by immune cells, DNA methylation-based epigenetic aging, and telomere length...
February 14, 2024: Mechanisms of Ageing and Development