keyword
https://read.qxmd.com/read/38370367/-hes4-is-a-potential-biomarker-for-bladder-cancer-a-mendelian-randomization-study
#21
JOURNAL ARTICLE
Zhiyong Tan, Xiaorong Chen, Haihao Li, Yinglong Huang, Shi Fu, Mingxia Ding, Jiansong Wang, Haifeng Wang
Background: Patients with bladder cancer (BLCA) have a poor prognosis and little progress has been made in treatment. Therefore, the purpose of this work was to employ Mendelian randomization (MR) and transcriptome analysis to identify a novel biomarker that could be used to reliably diagnose BLCA. Methods: TCGA-BLCA and GSE121711 datasets were obtained from public databases. Genome-wide association study (GWAS) data of BLCA outcome (373,295 samples containing 9,904,926 single nucleotide polymorphisms) were obtained through the IEU OpenGWAS database...
2024: Journal of Cancer
https://read.qxmd.com/read/38370241/identification-of-immune-infiltration-and-immune-related-biomarkers-of-periprosthetic-joint-infection
#22
JOURNAL ARTICLE
Zhuo Li, Zhi-Yuan Li, Zulipikaer Maimaiti, Fan Yang, Jun Fu, Li-Bo Hao, Ji-Ying Chen, Chi Xu
BACKGROUND: The immune response associated with periprosthetic joint infection (PJI) is an emerging but relatively unexplored topic. The aim of this study was to investigate immune cell infiltration in periprosthetic tissues and identify potential immune-related biomarkers. METHODS: The GSE7103 dataset from the GEO database was selected as the data source. Differentially expressed genes (DEGs) and significant modular genes in weighted correlation network analysis (WGCNA) were identified...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38364983/common-and-distinct-metabolomic-markers-related-to-immune-aging-in-western-european-and-east-african-populations
#23
JOURNAL ARTICLE
Ozlem Bulut, Godfrey S Temba, Valerie A C M Koeken, Simone J C F M Moorlag, L Charlotte J de Bree, Vera P Mourits, Vesla I Kullaya, Martin Jaeger, Cancan Qi, Niels P Riksen, Jorge Domínguez-Andrés, Cheng-Jian Xu, Leo A B Joosten, Yang Li, Quirijn de Mast, Mihai G Netea
In old age, impaired immunity causes high susceptibility to infections and cancer, higher morbidity and mortality, and poorer vaccination efficiency. Many factors, such as genetics, diet, and lifestyle, impact aging. This study aimed to investigate how immune responses change with age in healthy Dutch and Tanzanian individuals and identify common metabolites associated with an aged immune profile. We performed untargeted metabolomics from plasma to identify age-associated metabolites, and we correlated their concentrations with ex-vivo cytokine production by immune cells, DNA methylation-based epigenetic aging, and telomere length...
February 14, 2024: Mechanisms of Ageing and Development
https://read.qxmd.com/read/38353900/mast-cell-activation-syndrome-and-gut-dysfunction-diagnosis-and-management
#24
REVIEW
Matthew J Hamilton
PURPOSE OF REVIEW: Mast cell activation syndrome (MCAS) is a clinical disorder that may explain irritable bowel syndrome (IBS) type symptoms as well as other allergic symptoms experienced by an individual. The diagnosis and treatment of MCAS with specific focus on gastrointestinal (GI) manifestations is reviewed. RECENT FINDINGS: Although biomarkers for MCAS remain elusive, testing for baseline serum tryptase will distinguish the type of mast cell disorder and urine tests for mast cell mediator metabolites may support the diagnosis...
February 14, 2024: Current Gastroenterology Reports
https://read.qxmd.com/read/38338081/comparison-of-nucleosome-ferritin-and-ldh-levels-in-blood-with-clinical-response-before-and-after-electrochemotherapy-combined-with-il-12-gene-electrotransfer-for-the-treatment-of-mast-cell-tumours-in-dogs
#25
JOURNAL ARTICLE
Maša Vilfan, Urša Lampreht Tratar, Nina Milevoj, Alenka Nemec Svete, Maja Čemažar, Gregor Serša, Nataša Tozon
Electrochemotherapy (ECT) in combination with the gene electrotransfer of interleukin 12 (IL-12 GET) has been successfully used in veterinary medicine for the treatment of mast cell tumours (MCT), but the biomarkers that could predict response to this treatment have not yet been investigated. The aim of this study was to determine the plasma nucleosome and serum ferritin concentrations, as well as the lactate dehydrogenase (LDH) activity, in the serum of treated patients before and one and six months after treatment to evaluate their utility as potential biomarkers that could predict response to the combined treatment...
January 29, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38334110/a-comprehensive-bioinformatics-analysis-identifies-mitophagy-biomarkers-and-potential-molecular-mechanisms-in-hypertensive-nephropathy
#26
JOURNAL ARTICLE
Jiayou Liu, Luda Feng, Qi Jia, Jia Meng, Yun Zhao, Lei Ren, Ziming Yan, Manrui Wang, Jianguo Qin
Mitophagy, the selective removal of damaged mitochondria, plays a critical role in kidney diseases, but its involvement in hypertensive nephropathy (HTN) is not well understood. To address this gap, we investigated mitophagy-related genes in HTN, identifying potential biomarkers for diagnosis and treatment. Transcriptome datasets from the Gene Expression Omnibus database were analyzed, resulting in the identification of seven mitophagy related differentially expressed genes (MR-DEGs), namely PINK1, ULK1, SQSTM1, ATG5, ATG12, MFN2, and UBA52...
February 9, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38333620/pan-cancer-and-single-cell-analysis-reveal-thrap3-as-a-prognostic-and-immunological-biomarker-for-multiple-cancer-types
#27
JOURNAL ARTICLE
Ye-Peng Wang, Chao Ma, Xue-Kun Yang, Nan Zhang, Zhi-Gang Sun
Background: Thyroid hormone receptor-associated protein 3 (THRAP3) is of great significance in DNA damage response, pre-mRNA processing, and nuclear export. However, the biological activities of THRAP3 in pan-cancer remain unexplored. We aimed to conduct a comprehensive analysis of THRAP3 and validate its expression levels in lung cancer. Methods: A pan-cancer analysis was conducted to study the correlation of THRAP3 expression with clinical outcome and the tumor microenvironment based on the available bioinformatics databases...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38333021/sprr1b-is-related-to-the-immune-microenvironment-and-can-be-used-as-a-biomarker-for-the-diagnosis-of-psoriasis
#28
JOURNAL ARTICLE
Siyu Hao, Jiuyi Cong, Zhiqiang Ma, Yan Xia, Yu Zhang, Nannan Tong, Jiangtian Tian, Yuzhen Li
BACKGROUND: Psoriasis, a chronic inflammatory disorder with an unknown cause, significantly impacts the physical and psychological well-being of patients. However, current biomarkers related to psoriasis lack clinical specificity, sensitivity, and predictive ability. METHODS: In this study, we collected skin lesion tissues from 20 psoriasis patients and 20 normal skin samples. Additionally, we obtained four datasets from the GEO database, which included human psoriasis and healthy specimens...
2024: International Journal of General Medicine
https://read.qxmd.com/read/38332455/identification-of-immune-related-regulatory-networks-and-diagnostic-biomarkers-in-thyroid-eye-disease
#29
JOURNAL ARTICLE
Xiangmei Tong, Qianyun Shen
BACKGROUND: Thyroid eye disease (TED) is an orbit-associated autoimmune inflammatory disorder intricately linked to immune dysregulation. Complete pathogenesis of TED remains elusive. This work aimed to mine pathogenesis of TED from immunological perspective and identify diagnostic genes. METHODS: Gene expression microarray data for TED patients were downloaded from Gene Expression Omnibus, immune-related genes (IRGs) were from ImmPort database, and TED-related transcription factors (TFs) were from Cirtrome Cancer database...
February 8, 2024: International Ophthalmology
https://read.qxmd.com/read/38320734/bioinformatics-identification-of-potential-biomarkers-and-therapeutic-targets-for-ischemic-stroke-and-vascular-dementia
#30
JOURNAL ARTICLE
Ding Zhang, Ni Jia, Zhihan Hu, Zhou Keqing, Song Chenxi, Sun Chunying, Canrong Chen, Wei Chen, Yueqiang Hu, Ziyun Ruan
Ischemic stroke and vascular dementia, as common cerebrovascular diseases, with the former causing irreversible neurological damage and the latter causing cognitive and memory impairment, are closely related and have long received widespread attention. Currently, the potential causative genes of these two diseases have yet to be investigated, and effective early diagnostic tools for the diseases have not yet emerged. In this study, we screened new potential biomarkers and analyzed new therapeutic targets for both diseases from the perspective of immune infiltration...
February 6, 2024: Experimental Gerontology
https://read.qxmd.com/read/38310539/ptch1-mutation-as-a-potential-predictive-biomarker-for-immune-checkpoint-inhibitors-in-gastrointestinal-cancer
#31
JOURNAL ARTICLE
Shuangya Deng, Haoran Gu, Zong Yao Chen, Yaqin Liu, Qin Zhang, Dongsheng Chen, Shengen Yi
Immune checkpoint inhibitors (ICIs) have become prominent therapies for gastrointestinal cancer (GC). However, it is urgent to screen patients who can benefit from ICIs. Protein patched homolog 1 (PTCH1) is a frequently altered gene in GC. We attempt to explore the association between PTCH1 mutation and immunotherapy efficacy. The MSKCC cohort (n = 236) with GC (esophageal, gastric and colorectal cancers) patients receiving ICIs was used for discovery and the Peking University Cancer Hospital (PUCH) GC cohort (n = 92) was used for validation...
February 4, 2024: Carcinogenesis
https://read.qxmd.com/read/38308674/reversible-elevation-of-tryptase-over-the-individual-s-baseline-why-is-it-the-best-biomarker-for-severe-systemic-mast-cell-activation-and-mcas
#32
REVIEW
Peter Valent, Cem Akin, Michel Arock
PURPOSE OF REVIEW: Mast cell (MC) activation syndromes (MCAS) are conditions defined by recurrent episodes of severe systemic anaphylaxis or similar systemic events triggered by MC-derived mediators that can be measured in biological fluids. Since some symptoms of MC activation may occur due to other, non-MC etiologies and lead to confusion over diagnosis, it is of crucial importance to document the involvement of MC and their products in the patients´ symptomatology. RECENT FINDINGS: The most specific and generally accepted marker of severe systemic MC activation is an event-related, transient increase in the serum tryptase level over the individual baseline of the affected individual...
February 3, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38305332/integrated-bioinformatics-analysis-to-identify-a-novel-four-gene-prognostic-model-of-breast-cancer-and-reveal-its-association-with-immune-infiltration
#33
JOURNAL ARTICLE
Yunhua Zhu, Junjie Luo, Yifei Yang
Liquid-liquid phase separation (LLPS) impact immune signaling in cancer and related genes have shown prognostic value in breast cancer (BRCA). However, the crosstalk between LLPS and immune infiltration in BRCA remain unclear. Therefore, we aimed to develop a novel prognostic model of BRCA related to LLPS and immune infiltration. BRCA-related, liquid-liquid phase separation (LLPS)-related genes, and differentially expressed genes (DEGs) were identified using public databases. Mutation and drug sensitivity analyses were performed using Gene Set Cancer Analysis database...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/38301047/complementary-biomarkers-of-computed-tomography-for-diagnostic-grading-of-gastric-cancer-dscc1-and-gins1
#34
JOURNAL ARTICLE
Yufeng Zhu, Shiyang Hou, Chunbo Kang
OBJECTIVE: Computed tomography (CT) is an important tool for grading gastric cancer. Gastric cancer typically originates from epithelial cells of gastric mucosa. However, complementary markers for gastric cancer, relationship between DSCC1, GINS1 and gastric cancer remain unclear. METHODS: Gastric cancer data were obtained from gene expression omnibus (GEO). Differentially expressed genes (DEGs) were identified, weighted gene co-expression network analysis (WGCNA) was conducted...
January 31, 2024: Aging
https://read.qxmd.com/read/38298716/hif-1a-as-a-prognostic-biomarker-related-to-invasion-migration-and-immunosuppression-of-cervical-cancer
#35
JOURNAL ARTICLE
Zhenyu Li, Ran Wei, Shunyu Yao, Fang Meng, Lingsuo Kong
BACKGROUND: The incidence of cervical cancer ranks second among malignant tumors in women, exerting a significant impact on their quality of life and overall well-being. The hypoxic microenvironment plays a pivotal role in the initiation and progression of tumorigenesis. The present study aims to investigate the fundamental genes and pathways associated with the hypoxia-inducible factor (HIF-1A) in cervical cancer, aiming to identify potential downstream targets for diagnostic and therapeutic purposes...
January 30, 2024: Heliyon
https://read.qxmd.com/read/38290531/investigating-intestinal-mast-cell-dynamics-during-acute-heat-stress-in-growing-pigs
#36
JOURNAL ARTICLE
Edith J Mayorga, Sonia Rodriguez-Jimenez, Megan A Abeyta, Brady M Goetz, Julie Opgenorth, Adam J Moeser, Lance H Baumgard
Objectives were to examine the temporal pattern of intestinal mast cell dynamics and the effects of a mast cell stabilizer [ketotifen (Ket)] during acute heat stress (HS) in growing pigs. Crossbred barrows [n=42; 32.3±1.9 kg body weight (BW)] were randomly assigned to 1 of 7 environmental-therapeutic treatments: 1) thermoneutral (TN) control (TNCon; n=6), 2) 2 h HS control (2 h HSCon; n=6); 3) 2 h HS + Ket (2 h HSKet; n=6); 4) 6 h HS control (6 h HSCon; n=6); 5) 6 h HS + Ket (6 h HSKet; n=6); 6) 12 h HS control (12 h HSCon; n=6), or 7) 12 h HS + Ket (12 h HSKet; n=6)...
January 30, 2024: Journal of Animal Science
https://read.qxmd.com/read/38279482/prognosis-and-immunotherapy-significances-of-a-cancer-associated-fibroblasts-related-gene-signature-in-lung-adenocarcinoma
#37
JOURNAL ARTICLE
Yanli Luo, Sheng Zhang, Huilin Xie, Qiaofeng Su, Shuang He, Zhen Lei
Cells associated with cancer (CAFs) contribute significantly to the stroma of a tumor microenvironment (TME), which is related to the occurrence, treatment, and prognosis of lung adenocarcinoma (LUAD). Therefore, this study investigated the function of CAF-associated genes in the microenvironment of LUAD. The Cancer Genome Atlas (TCGA) database was used to download RNA-seq data from the TCGA Lung Adenocarcinoma cohort (TCGA-LUAD). The GSE68465 dataset, as the external validation set, was from the Gene Expression Omnibus (GEO) database...
December 20, 2023: Cellular and Molecular Biology
https://read.qxmd.com/read/38273392/comprehensive-analysis-revealed-the-immunoinflammatory-targets-of-rheumatoid-arthritis-based-on-intestinal-flora-mirna-transcription-factors-and-rna-binding-proteins-databases-gsea-and-gsva-pathway-observations-and-immunoinfiltration-typing
#38
JOURNAL ARTICLE
Yin Guan, Yue Zhang, Xiaoqian Zhao, Yue Wang
OBJECTIVE: Rheumatoid arthritis (RA) is a chronic inflammatory arthritis. This study aimed to identify potential biomarkers and possible pathogenesis of RA using various bioinformatics analysis tools. METHODS: The GMrepo database provided a visual representation of the analysis of intestinal flora. We selected the GSE55235 and GSE55457 datasets from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) separately. With the intersection of these DEGs with the target genes associated with RA found in the GeneCards database, we obtained the DEGs targeted by RA (DERATGs)...
January 25, 2024: Hereditas
https://read.qxmd.com/read/38270683/inhibitory-effect-of-rosmarinic-acid-on-ige-trigged-mast-cell-degranulation-in-vitro-and-in-vivo
#39
JOURNAL ARTICLE
Binmei Jia, Hao-Long Zeng, Jieli Shang, Xuanpei Wang, Lin Xu, Min Fang, Fengbo Zeng, Qing Yang
BACKGROUND: Rosmarinic acid (RA), a polyphenol from edible-medical Lamiaceae herbs, is known to possess a variety of pharmacological activity, like anti-inflammatory, hepatoprotective and immunoregulation activities. METHODS AND RESULTS: Hereon, we investigated the anti-allergic activity of RA on immunoglobulin E (IgE)-mediated anaphylaxis responses in rat basophilic leukemia (RBL)-2H3 mast cell. RA hindered the morphological changes of IgE-induced degranulated RBL-2H3 cells...
January 25, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38248039/challenges-in-the-diagnosis-of-cutaneous-mastocytosis
#40
REVIEW
Knut Brockow, Rebekka Karolin Bent, Simon Schneider, Sophie Spies, Katja Kranen, Benedikt Hindelang, Zsuzsanna Kurgyis, Sigurd Broesby-Olsen, Tilo Biedermann, Clive E Grattan
BACKGROUND: Mastocytosis is characterized by an accumulation of clonal mast cells (MCs) in tissues such as the skin. Skin lesions in mastocytosis may be clinically subtle or heterogeneous, and giving the correct diagnosis can be difficult. METHODS: This study compiles personal experiences together with relevant literature, discussing possible obstacles encountered in diagnosing skin involvement in mastocytosis and cutaneous mastocytosis (CM). RESULTS: The nomenclature of the term "CM" is ambiguous...
January 11, 2024: Diagnostics
keyword
keyword
106023
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.