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Dietary nitrates

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https://www.readbyqxmd.com/read/28708316/dietary-plant-sterols-supplementation-increases-in-vivo-nitrite-and-nitrate-production-in-healthy-adults-a-randomized-controlled-study
#1
Xing Lin Ho, Wai Mun Loke
A randomized, double-blinded, placebo-controlled and crossover study was conducted to simultaneously measure the effects, 3 h after consumption and after 4-wk daily exposure to plant sterols-enriched food product, on in vivo nitrite and nitrate production in healthy adults. Eighteen healthy participants (67% female, 35.3 [mean] ± 9.5 [SD] years, mean body mass index 22.8 kg/m(2) ) received 2 soy milk (20 g) treatments daily: placebo and one containing 2.0 g free plant sterols equivalent of their palmityl esters (β-sitosterol, 55%; campesterol, 29%; and stigmasterol, 23%)...
July 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28701247/the-effect-of-dietary-addition-of-nitrate-or-increase-in-lipid-concentrations-alone-or-in-combination-on-performance-and-methane-emissions-of-beef-cattle
#2
C-A Duthie, S M Troy, J J Hyslop, D W Ross, R Roehe, J A Rooke
Adding nitrate to or increasing the concentration of lipid in the diet are established strategies for reducing enteric methane (CH4) emissions, but their effectiveness when used in combination has been largely unexplored. This study investigated the effect of dietary nitrate and increased lipid included alone or together on CH4 emissions and performance traits of finishing beef cattle. The experiment was a 2×4 factorial design comprising two breeds (cross-bred Aberdeen Angus (AAx) and cross-bred Limousin (LIMx) steers) and four dietary treatments (each based on 550 g forage : 450 g concentrate/kg dry matter (DM))...
July 13, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28684588/dietary-nitrate-supplementation-increases-acute-mountain-sickness-severity-and-sense-of-effort-during-hypoxic-exercise
#3
Gabriella M K Rossetti, Jamie Hugo Macdonald, Lee J Wylie, Samuel J Little, Victoria Newton, Benjamin Wood, Kieran A Hawkins, Rhys Beddoe, Hannah E Davies, Samuel James Oliver
Dietary nitrate supplementation enhances sea level performance and may ameliorate hypoxemia at high altitude. However, nitrate may exacerbate acute mountain sickness (AMS), specifically headache. This study investigated the effect of nitrate supplementation on AMS symptoms and exercise responses with 6h hypoxia. Twenty recreationally-active men (mean(SD): age 22(4) years, V̇O2max 51(6) mL·min-1·kg-1) completed this randomized double-blinded placebo-controlled crossover study. Twelve participants were classified as AMS- based on Environmental Symptom Questionnaire (AMS-C) score <0...
July 6, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28670117/dietary-beetroot-juice-effects-on-physical-performance-in-copd-patients-a-randomized-controlled-crossover-trial
#4
Anne Louise Friis, Carina Bjørnskov Steenholt, Anders Løkke, Mette Hansen
BACKGROUND AND OBJECTIVE: Dietary beetroot juice (BR) supplementation has been shown to reduce the oxygen (O2) consumption of standardized exercise and reduce resting blood pressure (BP) in healthy individuals. However, the physiological response of BR in chronic obstructive pulmonary disease (COPD) remains controversial. The objective was to test exercise performance in COPD, supplementing with higher doses of BR for a longer duration compared to previous trials in this patient group...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28663382/sodium-nitrate-ingestion-increases-skeletal-muscle-nitrate-content-in-humans
#5
Jean Nyakayiru, Imre W K Kouw, Naomi M Cermak, Joan M Senden, Luc J C van Loon, Lex B Verdijk
Nitrate (NO3(-)) ingestion has been shown to have vasoactive and ergogenic effects that have been attributed to increased nitric oxide (NO) production. Recent observations in rodents suggest skeletal muscle tissue to serve as an endogenous NO3(-) "reservoir". The current study determined NO3(-) contents in human skeletal muscle tissue in a post-absorptive state, and following ingestion of a sodium nitrate bolus (NaNO3). Seventeen male, type 2 diabetes patients (age 72±1 y; BMI 26.5±0.5 m·kg(-2)) were randomized to ingest a dose of NaNO3 (NIT; 9...
June 29, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28649367/nitric-oxide-signalling-and-neuronal-nitric-oxide-synthase-in-the-heart-under-stress
#6
REVIEW
Yin Hua Zhang
Nitric oxide (NO) is an imperative regulator of the cardiovascular system and is a critical mechanism in preventing the pathogenesis and progression of the diseased heart. The scenario of bioavailable NO in the myocardium is complex: 1) NO is derived from both endogenous NO synthases (endothelial, neuronal, and/or inducible NOSs [eNOS, nNOS, and/or iNOS]) and exogenous sources (entero-salivary NO pathway) and the amount of NO from exogenous sources varies significantly; 2) NOSs are located at discrete compartments of cardiac myocytes and are regulated by distinctive mechanisms under stress; 3) NO regulates diverse target proteins through different modes of post-transcriptional modification (soluble guanylate cyclase [sGC]/cyclic guanosine monophosphate [cGMP]/protein kinase G [PKG]-dependent phosphorylation, S-nitrosylation, and transnitrosylation); 4) the downstream effectors of NO are multidimensional and vary from ion channels in the plasma membrane to signalling proteins and enzymes in the mitochondria, cytosol, nucleus, and myofilament; 5) NOS produces several radicals in addition to NO (e...
2017: F1000Research
https://www.readbyqxmd.com/read/28649204/effects-of-dietary-nitrate-supplementation-on-physiological-responses-cognitive-function-and-exercise-performance-at-moderate-and-very-high-simulated-altitude
#7
Oliver M Shannon, Lauren Duckworth, Matthew J Barlow, Kevin Deighton, Jamie Matu, Emily L Williams, David Woods, Long Xie, Blossom C M Stephan, Mario Siervo, John P O'Hara
Purpose: Nitric oxide (NO) bioavailability is reduced during acute altitude exposure, contributing toward the decline in physiological and cognitive function in this environment. This study evaluated the effects of nitrate ([Formula: see text]) supplementation on NO bioavailability, physiological and cognitive function, and exercise performance at moderate and very-high simulated altitude. Methods:Ten males (mean (SD): [Formula: see text]: 60.9 (10.1) ml·kg(-1)·min(-1)) rested and performed exercise twice at moderate (~14...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28623824/dietary-nitrate-attenuates-renal-ischemia-reperfusion-injuries-by-modulation-of-immune-responses-and-reduction-of-oxidative-stress
#8
Ting Yang, Xing-Mei Zhang, Laura Tarnawski, Maria Peleli, Zhengbing Zhuge, Niccolo Terrando, Robert A Harris, Peder S Olofsson, Erik Larsson, A Erik G Persson, Jon O Lundberg, Eddie Weitzberg, Mattias Carlstrom
Ischemia-reperfusion (IR) injury involves complex pathological processes in which reduction of nitric oxide (NO) bioavailability is suggested as a key factor. Inorganic nitrate can form NO in vivo via NO synthase-independent pathways and may thus provide beneficial effects during IR. Herein we evaluated the effects of dietary nitrate supplementation in a renal IR model. Male mice (C57BL/6J) were fed nitrate-supplemented chow (1.0mmol/kg/day) or standard chow for two weeks prior to 30min ischemia and during the reperfusion period...
June 9, 2017: Redox Biology
https://www.readbyqxmd.com/read/28610958/sulfate-nitrate-and-blood-pressure-an-epic-interaction-between-sulfur-and-nitrogen
#9
REVIEW
Gunter G Kuhnle, Robert Luben, Kay-Tee Khaw, Martin Feelisch
Nitrate (NO3(-))-rich foods such as green leafy vegetables are not only part of a healthy diet, but increasingly marketed for primary prevention of cardiovascular disease (CVD) and used as ergogenic aids by competitive athletes. While there is abundant evidence for mild hypotensive effects of nitrate on acute application there is limited data on chronic intake in humans, and results from animal studies suggest no long-term benefit. This is important as nitrate can also promote the formation of nitrosamines...
August 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28603910/production-of-n2-and-n2-o-from-nitrate-ingested-by-sheep
#10
V de Raphélis-Soissan, J V Nolan, I R Godwin, J R Newbold, B D Eyre, D V Erler, R S Hegarty
Supplementing ruminants with nitrate (NO3-) reduces their enteric methane (CH4 ) emissions; however, the greenhouse gas (GHG) mitigation achieved can be partially offset by small emissions of nitrous oxide (N2 O), a more potent GHG. Sheep were dosed intraruminally with (15) NO3- to investigate whether dietary NO3- is a precursor of N2 O and/or di-nitrogen gas (N2 ), and to quantify the amounts of NO3- recovered as N2 O and N2 in gas emissions from sheep adapted or not adapted to dietary NO3-. Ruminally cannulated sheep were adapted to a hay diet supplemented with NO3- (n = 3; 10 g NO3-/kg DM) or urea (n = 3; 5...
June 12, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28596764/the-structural-and-functional-capacity-of-ruminal-and-cecal-microbiota-in-growing-cattle-was-unaffected-by-dietary-supplementation-of-linseed-oil-and-nitrate
#11
Milka Popova, Emily McGovern, Matthew S McCabe, Cécile Martin, Michel Doreau, Marie Arbre, Sarah J Meale, Diego P Morgavi, Sinéad M Waters
Microorganisms in the digestive tract of ruminants differ in their functionality and ability to use feed constituents. While cecal microbiota play an important role in post-rumen fermentation of residual substrates undigested in the rumen, limited knowledge exists regarding its structure and function. In this trial we investigated the effect of dietary supplementation with linseed oil and nitrate on methane emissions and on the structure of ruminal and cecal microbiota of growing bulls. Animals were allocated to either a CTL (control) or LINNIT (CTL supplemented with 1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28596448/association-of-vegetable-nitrate-intake-with-carotid-atherosclerosis-and-ischemic-cerebrovascular-disease-in-older-women
#12
Catherine P Bondonno, Lauren C Blekkenhorst, Richard L Prince, Kerry L Ivey, Joshua R Lewis, Amanda Devine, Richard J Woodman, Jon O Lundberg, Kevin D Croft, Peter L Thompson, Jonathan M Hodgson
BACKGROUND AND PURPOSE: A short-term increase in dietary nitrate (NO3(-)) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). METHODS: Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998)...
June 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28596274/dietary-nitrate-restores-compensatory-vasodilation-and-exercise-capacity-in-response-to-a-compromise-in-oxygen-delivery-in-the-non-compensator-phenotype
#13
Robert F Bentley, Jeremy J Walsh, Patrick J Drouin, Aleksandra Velickovic, Sarah J Kitner, Alyssa M Fenuta, Michael E Tschakovsky
Recently dietary nitrate supplementation has been shown to improve exercise capacity in healthy individuals through a potential nitrate-nitrite-nitric oxide pathway. Nitric oxide has been shown to play an important role in compensatory vasodilation during exercise under hypoperfusion. Previously we established that certain individuals lack a vasodilation response when perfusion pressure reductions compromise exercising muscle blood flow. Whether this lack of compensatory vasodilation in healthy young individuals can be restored with dietary nitrate supplementation is unknown...
June 8, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28587887/effect-of-diet-and-gut-environment-on-the-gastrointestinal-formation-of-n-nitroso-compounds-a-review
#14
REVIEW
Jun Kobayashi
Diet is associated with the development of cancer in the gastrointestinal (GI) tract, because dietary nitrate and nitrite are the main nitrosating agents that are responsible for the formation of carcinogenic N-nitroso compounds (NOCs) when nitrosatable substrates, such as amine and amide, are present in the GI tract. However, whether the nitroso compounds become beneficial S-nitroso compounds or carcinogenic NOCs might depend on dietary and environmental factors including food stuffs, gastric acidity, microbial flora, and the mean transit time of digesta...
June 3, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28577258/-beet-ing-the-mountain-a-review-of-the-physiological-and-performance-effects-of-dietary-nitrate-supplementation-at-simulated-and-terrestrial-altitude
#15
Oliver Michael Shannon, Kerry McGawley, Linn Nybäck, Lauren Duckworth, Matthew John Barlow, David Woods, Mario Siervo, John Paul O'Hara
Exposure to altitude results in multiple physiological consequences. These include, but are not limited to, a reduced maximal oxygen consumption, drop in arterial oxygen saturation, and increase in muscle metabolic perturbations at a fixed sub-maximal work rate. Exercise capacity during fixed work rate or incremental exercise and time-trial performance are also impaired at altitude relative to sea level. Recently, dietary nitrate (NO3(-)) supplementation has attracted considerable interest as a nutritional aid during altitude exposure...
June 2, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28566306/association-of-dietary-nitrate-with-atherosclerotic-vascular-disease-mortality-a-prospective-cohort-study-of-older-adult-women
#16
Lauren C Blekkenhorst, Catherine P Bondonno, Joshua R Lewis, Amanda Devine, Richard J Woodman, Kevin D Croft, Wai H Lim, Germaine Wong, Lawrence J Beilin, Richard L Prince, Jonathan M Hodgson
Background: Nitrate-rich vegetables lower blood pressure and improve endothelial function in humans. It is not known, however, whether increased consumption of nitrate-rich vegetables translates to a lower risk of atherosclerotic vascular disease (ASVD) mortality.Objective: The objective was to investigate the association of nitrate intake from vegetables with ASVD mortality.Design: A total of 1226 Australian women aged 70-85 y without prevalent ASVD and/or diabetes were recruited in 1998 and were studied for 15 y...
May 31, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28566109/the-role-of-inorganic-nitrate-and-nitrite-in-cvd
#17
Jacklyn Jackson, Amanda J Patterson, Lesley MacDonald-Wicks, Mark McEvoy
CVD is the leading cause of death worldwide, a consequence of mostly poor lifestyle and dietary behaviours. Although whole fruit and vegetable consumption has been consistently shown to reduce CVD risk, the exact protective constituents of these foods are yet to be clearly identified. A recent and biologically plausible hypothesis supporting the cardioprotective effects of vegetables has been linked to their inorganic nitrate content. Approximately 60-80 % inorganic nitrate exposure in the human diet is contributed by vegetable consumption...
June 1, 2017: Nutrition Research Reviews
https://www.readbyqxmd.com/read/28562133/dietary-nitrate-does-not-modify-blood-pressure-and-cardiac-output-at-rest-and-during-exercise-in-older-adults-a-randomised-cross-over-study
#18
C Oggioni, D G Jakovljevic, M Klonizakis, A W Ashor, A Ruddock, M Ranchordas, E Williams, M Siervo
Dietary nitrate (NO3(-)) supplementation has been associated with improved vascular and metabolic health. We conducted a double-blind, cross-over, placebo-controlled RCT to investigate the effects of 7-d consumption of beetroot juice compared with placebo on (1) blood pressure (BP) measured in resting conditions and during exercise, (2) cardiac and peripheral vascular function and (3) biomarkers of inflammation, oxidative stress and endothelial integrity. Twenty non-smoking healthy participants aged 60-75 years and BMI 20...
May 31, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28549665/effects-of-supervised-exercise-and-dietary-nitrate-in-older-adults-with-controlled-hypertension-and-or-heart-failure-with-preserved-ejection-fraction
#19
Hossam A Shaltout, Joel Eggebeen, Anthony P Marsh, Peter H Brubaker, Paul J Laurienti, Jonathan H Burdette, Swati Basu, Ashley Morgan, Patricia C Dos Santos, James L Norris, Timothy M Morgan, Gary D Miller, W Jack Rejeski, Amret T Hawfield, Debra I Diz, J Thomas Becton, Daniel B Kim-Shapiro, Dalane W Kitzman
Aerobic exercise training is an effective therapy to improve peak aerobic power (peak VO2) in individuals with hypertension (HTN, AHA/ACC class A) and heart failure patients with preserved ejection fraction (HFpEF). High nitrate containing beetroot juice (BRJ) also improves sub-maximal endurance and decreases blood pressure in both HTN and HFpEF. We hypothesized that combining an aerobic exercise and dietary nitrate intervention would result in additive or even synergistic positive effects on exercise tolerance and blood pressure in HTN or HFpEF...
May 23, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28511731/dietary-nitrate-and-blood-pressure-evolution-of-a-new-nutrient
#20
Ann Ashworth, Raul Bescos
Dietary nitrate is mainly obtained from vegetables, especially green leafy vegetables and beetroot. As a result of early research, dietary nitrate is currently viewed as a contaminant linked to increased risks of stomach cancer and methaemoglobinaemia. Consequently, nitrate levels are restricted in certain vegetables and in water supplies to ensure exposure levels remain below an acceptable daily intake of 3·7 mg/kg per d. The average nitrate intake in the UK is approximately 70 mg/d, although some population groups, such as vegetarians, may consume three times that amount...
May 17, 2017: Nutrition Research Reviews
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