keyword
https://read.qxmd.com/read/38182578/a-framework-for-frizzled-g-protein-coupling-and-implications-to-the-pcp-signaling-pathways
#21
JOURNAL ARTICLE
Zhibin Zhang, Xi Lin, Ling Wei, Yiran Wu, Lu Xu, Lijie Wu, Xiaohu Wei, Suwen Zhao, Xiangjia Zhu, Fei Xu
The ten Frizzled receptors (FZDs) are essential in Wnt signaling and play important roles in embryonic development and tumorigenesis. Among these, FZD6 is closely associated with lens development. Understanding FZD activation mechanism is key to unlock these emerging targets. Here we present the cryo-EM structures of FZD6 and FZD3 which are known to relay non-canonical planar cell polarity (PCP) signaling pathways as well as FZD1 in their G protein-coupled states and in the apo inactive states, respectively...
January 5, 2024: Cell Discovery
https://read.qxmd.com/read/38172596/wtap-mediated-m-6-a-modification-of-frzb-triggers-the-inflammatory-response-via-the-wnt-signaling-pathway-in-osteoarthritis
#22
JOURNAL ARTICLE
Xueying An, Rongliang Wang, Zhongyang Lv, Wenshu Wu, Ziying Sun, Rui Wu, Wenjin Yan, Qing Jiang, Xingquan Xu
Osteoarthritis (OA) is the most common form of arthritis. However, the exact pathogenesis remains unclear. Emerging evidence shows that N6-methyladenosine (m6 A) modification may have an important role in OA pathogenesis. This study aimed to investigate the role of m6 A writers and the underlying mechanisms in osteoarthritic cartilage. Among m6 A methyltransferases, Wilms tumor 1-associated protein (WTAP) expression most significantly differed in clinical osteoarthritic cartilage. WTAP regulated extracellular matrix (ECM) degradation, inflammation and antioxidation in human chondrocytes...
January 4, 2024: Experimental & Molecular Medicine
https://read.qxmd.com/read/38154460/extracellular-carriers-control-lipid-dependent-secretion-delivery-and-activity-of-wnt-morphogens
#23
JOURNAL ARTICLE
Taciani de Almeida Magalhaes, Jingjing Liu, Charlene Chan, Kleiton Silva Borges, Jiuchun Zhang, Andrew J Kane, Bradley M Wierbowski, Yunhui Ge, Zhiwen Liu, Prabhath Mannam, Daniel Zeve, Ron Weiss, David T Breault, Pengxiang Huang, Adrian Salic
WNT morphogens trigger signaling pathways fundamental for embryogenesis, regeneration, and cancer. WNTs are modified with palmitoleate, which is critical for binding Frizzled (FZD) receptors and activating signaling. However, it is unknown how WNTs are released and spread from cells, given their strong lipid-dependent membrane attachment. We demonstrate that secreted FZD-related proteins and WNT inhibitory factor 1 are WNT carriers, potently releasing lipidated WNTs and forming active soluble complexes. WNT release occurs by direct handoff from the membrane protein WNTLESS to the carriers...
December 21, 2023: Developmental Cell
https://read.qxmd.com/read/38151510/characterization-of-wnt-signaling-pathway-under-treatment-of-lactobacillus-acidophilus-postbiotic-in-colorectal-cancer-using-an-integrated-in-silico-and-in-vitro-analysis
#24
JOURNAL ARTICLE
Nafiseh Erfanian, Saeed Nasseri, Adib Miraki Feriz, Hossein Safarpour, Mohammad Hassan Namaie
Colorectal cancer (CRC) is a prevalent and life-threatening cancer closely associated with the gut microbiota. Probiotics, as a vital microbiota group, interact with the host's colonic epithelia and immune cells by releasing a diverse range of metabolites named postbiotics. The present study examined the effects of postbiotics on CRC's prominent differentially expressed genes (DEGs) using in silico and in vitro analysis. Through single-cell RNA sequencing (scRNA-seq), we identified four DEGs in CRC, including secreted frizzled-related protein 1 (SFRP1), secreted frizzled-related protein 2 (SFRP2), secreted frizzled-related protein 4 (SFRP4), and matrix metallopeptidase 7 (MMP7)...
December 27, 2023: Scientific Reports
https://read.qxmd.com/read/38124068/genome-wide-identification-and-spatiotemporal-expression-analysis-of-cadherin-superfamily-members-in-echinoderms
#25
JOURNAL ARTICLE
Macie M Chess, William Douglas, Josiah Saunders, Charles A Ettensohn
BACKGROUND: Cadherins are calcium-dependent transmembrane cell-cell adhesion proteins that are essential for metazoan development. They consist of three subfamilies: classical cadherins, which bind catenin, protocadherins, which contain 6-7 calcium-binding repeat domains, and atypical cadherins. Their functions include forming adherens junctions, establishing planar cell polarity (PCP), and regulating cell shape, proliferation, and migration. Because they are basal deuterostomes, echinoderms provide important insights into bilaterian evolution, but their only well-characterized cadherin is G-cadherin, a classical cadherin that is expressed by many embryonic epithelia...
December 20, 2023: EvoDevo
https://read.qxmd.com/read/38115892/trifuhalol-a-a-phlorotannin-from-the-brown-algae-agarum-cribrosum-reduces-adipogenesis-of-human-primary-adipocytes-through-wnt-%C3%AE-catenin-and-ampk-dependent-pathways
#26
JOURNAL ARTICLE
Aaron Taehwan Kim, Yeonhwa Park
Trifuhalol A, a fucol-type phlorotannin, was extracted and identified from the brown algae Agarum cribrosum . The total yield and purity of trifuhalol A from A. cribrosum were 0.98% and 86%, respectively. Trifuhalol A at 22 and 44 μM inhibited lipid accumulation in human primary adipocytes. Consistently trifuhalol A suppressed the expression of adipogenesis-related genes, such as proliferator-activated receptor-gamma (PPAR-γ), CCAAT/enhancer-binding protein-alpha (C/EBP-α), fatty acid synthase (FAS), and sterol regulatory element-binding protein-1 (SREBP-1), in a dose-dependent manner...
2023: Current research in food science
https://read.qxmd.com/read/38101654/secreted-frizzled-related-protein-2-ameliorates-diabetic-cardiomyopathy-by-activating-mitophagy
#27
JOURNAL ARTICLE
Haoxiao Zheng, Weiwen Li, Guolin Huang, Hailan Zhu, Weixing Wen, Xiong Liu, Lichang Sun, Tianyi Ma, Xiaohui Huang, Yunzhao Hu, Yuli Huang
OBJECTIVES: Secreted frizzled-related protein 2 (SFRP2), a novel adipokine that used to be considered an inhibitor of the canonical Wnt pathway, may play a protective role in metabolic disorders. However, its effect on diabetic cardiomyopathy was still unclear. Accumulating evidence indicates that mitophagy can protect cardiac function in the diabetic heart. The present study aimed to explore the roles of SFRP2 on diabetic cardiomyopathy, focusing on the effects and mechanisms for regulating mitophagy...
December 13, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/38071975/secreted-frizzled-related-protein-4-induces-gastric-cancer-progression-and-resistance-to-cisplatin-and-oxaliplatin-via-%C3%AE-catenin-dysregulation
#28
JOURNAL ARTICLE
Chun-Han Chen, Chih-Jung Chen, Yi-Ching Huang, Po-Shuan Huang, Hsiang-Cheng Chi, Huei-Chieh Chuang, Meng-Hung Lin, Tzu-Hao Huang, Jun-Te Hsu, Cheng-Yi Chen
INTRODUCTION: Gastric cancer is the 5th most common cancer and 3rd leading cause of cancer-related death worldwide. There are three main ways to treat gastric cancer: surgical resection, radiation therapy, and drug therapy. Furthermore, combinations of two to three regimens can improve survival. However, the survival outcomes of chemotherapy in advanced gastric cancer patients are still unsatisfactory. Unfortunately, no widely useful biomarkers have been verified to predict the efficacy of chemotherapy for locally advanced gastric cancer...
December 10, 2023: Chemotherapy
https://read.qxmd.com/read/38046159/sox8-promotes-tumor-growth-and-metastasis-through-fzd6-dependent-wnt-%C3%AE-catenin-signaling-in-colorectal-carcinoma
#29
JOURNAL ARTICLE
Chen Li, Boran Cheng, Xiaodong Yang, Gangling Tong, Fen Wang, Mengqing Li, Xiangyu Wang, Shubin Wang
SOX8 plays an important role in several physiological processes. Its expression is negatively associated with overall survival in patients with colorectal carcinoma (CRC), suggesting SOX8 is a potential prognostic factor for this disease. However, the role of SOX8 in CRC remains largely unknown. In this study, our data showed that SOX8 expression was upregulated in CRC cell lines and tumor tissues. Stable knockdown of SOX8 in CRC cell lines dramatically reduced cell proliferation, migration, and invasion. Furthermore, the knockdown of SOX8 decreased the phospho-GSK3β level and suppressed Frizzled-6 (FZD6) transcription; restoration of FZD6 expression partially abolished the effect of SOX8 on Wnt/β-catenin signaling and promote CRC cell proliferation...
December 2023: Heliyon
https://read.qxmd.com/read/38043953/the-complex-relationship-of-wnt-signaling-pathways-and-cilia
#30
JOURNAL ARTICLE
Linh T Vuong, Marek Mlodzik
Wnt family proteins are secreted glycolipoproteins that signal through multitude of signal transduction pathways. The Wnt-pathways are conserved and critical in all metazoans. They are essential for embryonic development, organogenesis and homeostasis, and associated with many diseases when defective or deregulated. Wnt signaling pathways comprise the canonical Wnt pathway, best known for its stabilization of β-catenin and associated nuclear β-catenin activity in gene regulation, and several non-canonical signaling branches...
2023: Current Topics in Developmental Biology
https://read.qxmd.com/read/38033424/a-conserved-role-for-frizzled-in-sleep-architecture
#31
JOURNAL ARTICLE
Nicholas R Gessner, Morteza Peiravi, Fan Zhang, Shemsiya Yimam, Danielle Springer, Susan T Harbison
Previous studies of natural variants in Drosophila melanogaster implicated the Wnt signaling receptor frizzled in sleep. Given that the Wnt signaling pathway is highly conserved across species, we hypothesized that frizzled class receptor 1 ( Fzd1 ), the murine homolog of frizzled , would also have a role in sleep. Using a CRISPR transgenic approach, we removed most of the Fzd1 coding region from C57BL/6N mice. We used a video assay to measure sleep characteristics in Fzd1 -deficient mice. As Wnt signaling is known to affect visuospatial memory, we also examined the impact of the deletion on learning and memory using the novel object recognition (NOR) paradigm...
2023: Sleep advances: a journal of the Sleep Research Society
https://read.qxmd.com/read/38000028/intestinal-paneth-cell-differentiation-relies-on-asymmetric-regulation-of-wnt-signaling-by-daam1-2
#32
JOURNAL ARTICLE
Gabriele Colozza, Heetak Lee, Alessandra Merenda, Szu-Hsien Sam Wu, Andrea Català-Bordes, Tomasz W Radaszkiewicz, Ingrid Jordens, Ji-Hyun Lee, Aileen-Diane Bamford, Fiona Farnhammer, Teck Yew Low, Madelon M Maurice, Vítězslav Bryja, Jihoon Kim, Bon-Kyoung Koo
The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem cells residing at the crypt bottom. Paneth cells form a major element of the niche microenvironment providing various growth factors to orchestrate intestinal stem cell homeostasis, such as Wnt3. Different Wnt ligands can selectively activate β-catenin-dependent (canonical) or -independent (noncanonical) signaling. Here, we report that the Dishevelled-associated activator of morphogenesis 1 (Daam1) and its paralogue Daam2 asymmetrically regulate canonical and noncanonical Wnt (Wnt/PCP) signaling...
November 24, 2023: Science Advances
https://read.qxmd.com/read/37999144/concentration-of-secreted-frizzled-related-proteins-sfrps-in-non-small-cell-lung-carcinoma-subtypes-a-preliminary-study
#33
JOURNAL ARTICLE
Jadwiga Gaździcka, Agata Świętek, Dorota Hudy, Natalia Dąbrowska, Karolina Gołąbek, Mateusz Rydel, Damian Czyżewski, Joanna Katarzyna Strzelczyk
Non-small cell lung carcinoma (NSCLC) is the most common lung cancer worldwide. Secreted frizzled-related proteins (SFRPs) are important tumour suppressors and antagonists of the Wnt signalling pathway, which is linked with cancer development. The aim of this study was to evaluate the concentrations of SFRP1, SFRP2, and SFRP5 proteins in tumour and non-tumour (NT) samples obtained from 65 patients with primary NSCLC. An enzyme-linked immunosorbent assay (ELISA) was used to measure the concentrations of SFRPs in the tissue homogenates...
November 18, 2023: Current Oncology
https://read.qxmd.com/read/37979393/the-role-of-wnt-palmitoleylated-loop-conserved-disulfide-bonds-in-wnt-frizzled-complex-structural-dynamics-insights-from-molecular-dynamics-simulations
#34
JOURNAL ARTICLE
N Dehghanbanadaki, H Mehralitabar, R Sotoudeh, H Naderi-Manesh
Wnts are lipid-modified proteins rich in cysteine, regulating developmental processes, and are involved in various pathological conditions. Wnts structure resembles a hand, with a palmitoleylated thumb and an index finger-like domain interacting with frizzled (FZ) receptors. Previous research shows the palmitoleyl group and the disulfides importance in Wnt folding, secretion, and function, but the structural basis is not fully understood. Here, we utilized classical molecular dynamics simulation (800-ns in total) to investigate how the thumb palmitoleyl and its close conserved disulfides (183-190, 181-195) regulated Wnt-FZ interaction and structural dynamics...
November 11, 2023: Computers in Biology and Medicine
https://read.qxmd.com/read/37956579/mir-92b-ameliorates-lipoteichoic-acid-induced-endometritis-by-suppressing-wnt-%C3%AE-catenin-pathway-activation
#35
JOURNAL ARTICLE
Zhijie Zheng, Yingfang Guo, Yonghui Zheng, Haichong Wu
Endometritis is one of the important reasons for the low fecundity of dairy cows, which has brought huge economic losses to the dairy industry. Emerging evidence suggests that miR-92b is a novel therapeutic molecule that plays a crucial role in many inflammatory diseases. However, its mechanism in lipoteichoic acid (LTA) induced endometritis remains unclear. In the present study, we explored the mechanism of miR-92b on LTA-induced endometritis in vivo and in vitro. The result displayed that the expression of miR-92b was reduced in LTA induced mouse endometritis and bovine endometrial epithelial cell lines (BEND)...
November 7, 2023: Theriogenology
https://read.qxmd.com/read/37943878/targeted-inhibition-of-wnt-signaling-with-a-clostridioides-difficile-toxin-b-fragment-suppresses-breast-cancer-tumor-growth
#36
JOURNAL ARTICLE
Aina He, Songhai Tian, Oded Kopper, Daniel J Horan, Peng Chen, Roderick T Bronson, Ren Sheng, Hao Wu, Lufei Sui, Kun Zhou, Liang Tao, Quan Wu, Yujing Huang, Zan Shen, Sen Han, Xueqing Chen, Hong Chen, Xi He, Alexander G Robling, Rongsheng Jin, Hans Clevers, Dongxi Xiang, Zhe Li, Min Dong
Wnt signaling pathways are transmitted via 10 homologous frizzled receptors (FZD1-10) in humans. Reagents broadly inhibiting Wnt signaling pathways reduce growth and metastasis of many tumors, but their therapeutic development has been hampered by the side effect. Inhibitors targeting specific Wnt-FZD pair(s) enriched in cancer cells may reduce side effect, but the therapeutic effect of narrow-spectrum Wnt-FZD inhibitors remains to be established in vivo. Here, we developed a fragment of C. difficile toxin B (TcdBFBD), which recognizes and inhibits a subclass of FZDs, FZD1/2/7, and examined whether targeting this FZD subgroup may offer therapeutic benefits for treating breast cancer models in mice...
November 2023: PLoS Biology
https://read.qxmd.com/read/37926311/identification-and-functional-validation-of-fzd8-specific-antibodies
#37
JOURNAL ARTICLE
Na Li, Qiangqiang Ge, Qiong Guo, Yuyong Tao
The Wnt pathway is an evolutionarily conserved pathway involved in stem cell homeostasis and tissue regeneration. Aberrant signaling in the Wnt pathway is highly associated with cancer. Developing antibodies to block overactivation of Frizzled receptors (FZDs), the main receptors in the Wnt pathway, is one of the viable options for treating cancer. However, obtaining isoform-specific antibodies is often challenging due to the high degree of homology among the ten FZDs. In this study, by using a synthetic library, we identified an antibody named pF8_AC3 that preferentially binds to FZD8...
November 3, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37905348/in-vitro-hair-growth-promoting-effect-of-lgr5-binding-octapeptide-in-human-primary-hair-cells
#38
JOURNAL ARTICLE
Eung Ji Lee, Min Woong Kim, Ha-Na Gil, Yong Ji Chung, Eun Mi Kim
BACKGROUND: Hair loss occurs due to various biological and environmental causes, which can have psychosocial consequences. The Wnt/β-catenin signaling is well-known for its role in hair growth and regeneration, as it induces the proliferation and differentiation of hair cells. When the leucine-rich G protein-coupled receptor 5 (Lgr5) interacts with the R-spondins, the frizzled receptor (FZD), a Wnt receptor, becomes stabilized, resulting in an increased β-catenin activity...
October 31, 2023: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/37869648/frzb-affects-staphylococcus-aureus%C3%A2-induced-osteomyelitis-in-human-bone-marrow-derived-stem-cells-by-regulating-the-wnt-%C3%AE-%C3%A2-catenin-signaling-pathway
#39
JOURNAL ARTICLE
Xin Li, Wenyong Pang, Hongsong Fan, Hao Wang, Leibing Zhang
Osteomyelitis is an infectious disease of bone tissue caused by bacterial infection, which can infect through hematogenous, traumatic or secondary ways and then lead to acute or chronic bone injury and relative clinical symptoms, bringing physical injury and economic burden to patients. Frizzled related protein (FRZB) participates in the regulation of various diseases (osteoarthritis, cardiovascular diseases and types of cancer) by regulating cell proliferation, motility, differentiation and inflammation, while its function in osteomyelitis remains to be elucidated...
November 2023: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/37859826/highly-expressed-mir-144-3p-promotes-the-proliferation-migration-and-invasion-of-colon-carcinoma-cells-by-activating-the-wnt-%C3%AE-catenin-signaling-pathway-through-targeting-sfrp1
#40
JOURNAL ARTICLE
Chunhui Lai, Ningyu He, Jianghui Zeng, Cuizhen Long, Mingfang Shi, Junguo Li, Shengjun Ma, Yu Xiong, Xiuyun Liang
Background: To investigate the influence of miR-144-3p on the proliferation, migration and invasion of colon carcinoma by targeting secreted frizzled-related protein 1 (SFRP1) as well as of the Wnt/β-catenin signaling pathway. Methods: Based on the TCGA database, the association between the expression of miR-144-3p and the clinical information and prognosis of patients with colon carcinoma was examined, and SFRP1 was selected as the target gene for further studies based on bioinformatics prediction tools...
2023: Journal of Cancer
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