keyword
https://read.qxmd.com/read/38431571/perioperative-factors-associated-with-survival-following-surgery-for-pancreatic-cancer-a-nationwide-analysis-of-473-cases-from-denmark
#21
JOURNAL ARTICLE
Laura Marr Spore, Emilie Even Dencker, Eske Aasvang Kvanner, Carsten Palnaes Hansen, Stefan Kobbelgaard Burgdorf, Paul Suno Krohn, Sophie Louise Gisela Kollbeck, Jan Henrik Storkholm, Martin Sillesen
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers worldwide, with an overall 5-year survival rate of only 5%. The effect of perioperative treatment factors including duration of surgery, blood transfusions as well as choice of anesthesia and analgesia techniques on overall survival (OS) following pancreatic resections for PDAC, is currently not well known. We hypothesized that these perioperative factors might be associated with OS after pancreatic resections for PDAC...
March 2, 2024: BMC Surgery
https://read.qxmd.com/read/38428047/early-signals-of-posidonia-oceanica-meadows-recovery-in-a-context-of-wastewater-treatment-improvements
#22
JOURNAL ARTICLE
Thomas Bockel, Guilhem Marre, Gwenaëlle Delaruelle, Noémie Agel, Pierre Boissery, François Guilhaumon, Nicolas Mouquet, David Mouillot, Antonin Guilbert, Julie Deter
Natural ecological restoration is a cornerstone of modern conservation science and managers need more documented "success stories" to lead the way. In French mediterranean sea, we monitored Posidonia oceanica lower limit using acoustic telemetry and photogrammetry and investigated the descriptors driving its variations, at a national scale and over more than a decade. We showed significant effects of environmental descriptors (region, sea surface temperature and bottom temperature) but also of wastewater treatment plant (WWTP) effluents proxies (size of WWTP, time since conformity, and distance to the closest effluent) on the meadows lower limit progression...
February 29, 2024: Marine Pollution Bulletin
https://read.qxmd.com/read/38425168/a-review-of-pediatric-ophthalmic-tumors
#23
REVIEW
Lauren B Yeager, Alexis Kassotis, Tahvi Frank, Chloe Y Li, Brian P Marr
Tumors of the eye, orbit, and ocular adnexa can arise in the pediatric population. These entities can be both vision- and life-threatening and may be associated with systemic disease. Given their relative rarity, pediatricians must be aware of these conditions and understand what findings warrant immediate referral to an ophthalmologist for initiation of further testing. We aimed to review these conditions and highlight clinical features to promote awareness and expedite diagnosis. Tumors are subdivided into the following categories for review: anterior tumors of the eyelid and ocular surface, orbital tumors, and intraocular tumors...
March 1, 2024: Pediatrics in Review
https://read.qxmd.com/read/38423799/optimising-the-management-of-peanut-allergy-by-targeting-immune-plasticity
#24
REVIEW
Alan Nguyen, George du Toit, Gideon Lack, Tom Marrs
Randomised controlled trials investigating the efficacy of oral tolerance induction to peanut have enabled detailed comparison of their clinical and immunological success. They have demonstrated that the regular consumption of peanut for at least 2 years by babies who are not allergic enables protection from developing peanut allergy. The LEAP study intervention tested the impact of regular peanut consumption for 4 years and demonstrated a sustained protection against the development of peanut allergy even after 12 months of peanut avoidance from 5 to 6 years of age...
February 29, 2024: Clinical and Experimental Allergy
https://read.qxmd.com/read/38422623/effectiveness-of-hybrid-digital-breast-tomosynthesis-digital-mammography-compared-to-digital-mammography-in-women-presenting-for-routine-screening-at-maroondah-breastscreen-study-protocol-for-a-co-designed-non-randomised-prospective-trial
#25
JOURNAL ARTICLE
Nehmat Houssami, Darren Lockie, Michelle Giles, Sally Doncovio, Georgina Marr, David Taylor, Tong Li, Brooke Nickel, M Luke Marinovich
BACKGROUND: Digital breast tomosynthesis (DBT) for breast cancer screening has been shown in international trials to increase cancer detection compared with mammography; however, results have varied across screening settings, and currently there is limited and conflicting evidence on interval cancer rates (a surrogate for screening effectiveness). Australian pilot data also indicated substantially longer screen-reading time for DBT posing a barrier for adoption. There is a critical need for evidence on DBT to inform its role in Australia, including evaluation of potentially more feasible models of implementation, and quantification of screening outcomes by breast density which has global relevance...
February 21, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38422122/the-immunopathological-landscape-of-human-pre-tcr%C3%AE-deficiency-from-rare-to-common-variants
#26
JOURNAL ARTICLE
Marie Materna, Ottavia M Delmonte, Marita Bosticardo, Mana Momenilandi, Peyton E Conrey, Bénédicte Charmeteau-De Muylder, Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm, Frederik Staels, Christian A Ganoza, Samuel Darko, Samir Sayed, Corentin Le Floc'h, Masato Ogishi, Darawan Rinchai, Andrea Guenoun, Alexandre Bolze, Taushif Khan, Adrian Gervais, Renate Krüger, Mirjam Völler, Boaz Palterer, Mahnaz Sadeghi-Shabestari, Anne Langlois de Septenville, Chaim A Schramm, Sanjana Shah, John J Tello-Cajiao, Francesca Pala, Kayla Amini, Jose S Campos, Noemia Santana Lima, Daniel Eriksson, Romain Lévy, Yoann Seeleuthner, Soma Jyonouchi, Manar Ata, Fatima Al Ali, Caroline Deswarte, Anaïs Pereira, Jérôme Mégret, Tom Le Voyer, Paul Bastard, Laureline Berteloot, Michaël Dussiot, Natasha Vladikine, Paula P Cardenas, Emmanuelle Jouanguy, Mashael Alqahtani, Amal Hasan, Thangavel Alphonse Thanaraj, Jérémie Rosain, Fahd Al Qureshah, Vito Sabato, Marie Alexandra Alyanakian, Marianne Leruez-Ville, Flore Rozenberg, Elie Haddad, Jose R Regueiro, Maria L Toribio, Judith R Kelsen, Mansoor Salehi, Shahram Nasiri, Mehdi Torabizadeh, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Nasimeh Vatandoost, Hossein Moravej, Seyed Mohammad Akrami, Mohsen Mazloomrezaei, Aurélie Cobat, Isabelle Meyts, Etsushi Toyofuku, Madoka Nishimura, Kunihiko Moriya, Tomoyuki Mizukami, Kohsuke Imai, Laurent Abel, Bernard Malissen, Fahd Al-Mulla, Fowzan Sami Alkuraya, Nima Parvaneh, Horst von Bernuth, Christian Beetz, Frédéric Davi, Daniel C Douek, Rémi Cheynier, David Langlais, Nils Landegren, Nico Marr, Tomohiro Morio, Mohammad Shahrooei, Rik Schrijvers, Sarah E Henrickson, Hervé Luche, Luigi D Notarangelo, Jean-Laurent Casanova, Vivien Béziat
We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre-α T cell receptor (pre-TCRα) expression. Low circulating naive αβ T cell counts at birth persisted over time, with normal memory αβ and high γδ T cell counts. Their TCRα repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue αβ T cell development. Only a minority of these individuals were sick, with infection, lymphoproliferation, and/or autoimmunity...
March 2024: Science
https://read.qxmd.com/read/38419156/invasive-fungal-infections-in-inpatient-solid-organ-transplant-recipients-with-covid-19-a-multicenter-retrospective-cohort
#27
JOURNAL ARTICLE
Nitipong Permpalung, Teresa Po-Yu Chiang, Kasama Manothummetha, Darin Ostrander, Kausik Datta, Dorry L Segev, Christine M Durand, Heba H Mostafa, Sean X Zhang, Allan B Massie, Kieren A Marr, Robin K Avery
BACKGROUND: The prevalence and outcomes of COVID-19-associated invasive fungal infections (CAIFIs) in solid organ transplant recipients (SOTRs) remain poorly understood. METHODS: A retrospective cohort study of SOTRs with COVID-19 admitted to 5 hospitals within Johns Hopkins Medicine was performed between March 2020 and March 2022. Cox regression multilevel mixed-effects ordinal logistic regression was used. RESULTS: In the cohort of 276 SOTRs, 22 (8%) developed IFIs...
February 29, 2024: Transplantation
https://read.qxmd.com/read/38412831/pxpermute-reveals-staining-importance-in-multichannel-imaging-flow-cytometry
#28
JOURNAL ARTICLE
Sayedali Shetab Boushehri, Aleksandra Kornivetc, Domink J E Winter, Salome Kazeminia, Katharina Essig, Fabian Schmich, Carsten Marr
Imaging flow cytometry (IFC) allows rapid acquisition of numerous single-cell images per second, capturing information from multiple fluorescent channels. However, the traditional process of staining cells with fluorescently labeled conjugated antibodies for IFC analysis is time consuming, expensive, and potentially harmful to cell viability. To streamline experimental workflows and reduce costs, it is crucial to identify the most relevant channels for downstream analysis. In this study, we introduce PXPermute, a user-friendly and powerful method for assessing the significance of IFC channels, particularly for cell profiling...
February 26, 2024: Cell Rep Methods
https://read.qxmd.com/read/38410608/phase-i-ii-study-to-evaluate-consolidative-hypofractionated-radiation-therapy-for-boosting-the-residual-primary-disease-in-combination-with-durvalumab-after-definitive-chemoradiation-therapy-for-stage-iii-non-small-cell-lung-cancer-nsclc-study-protocol-for
#29
JOURNAL ARTICLE
Brendan Coutu, Elliot Lawrence, Apar Kishor Ganti, Alissa Marr, Chris Wichman, Chi Zhang
BACKGROUND: Recent advancements in the management of non-small cell lung cancer (NSCLC) have confirmed the utility of adding adjuvant immunotherapy to concurrent chemoradiotherapy in stage III disease but intrathoracic progression remains at high rate. Additional studies have sought to investigate the synergistic relationship of immunotherapy and radiation therapy (RT). The goal of this study is to evaluate the safety and efficacy of combining consolidative hypofractionated radiation therapy (hfRT) using stereotactic body radiotherapy (SBRT) technique for boosting the residual primary lung cancer with adjuvant anti-programmed death-ligand 1 (PD-L1) therapy concurrently after completion of definitive chemoradiation therapy (dCRT) in the rates of tumor control locoregionally and distantly...
January 30, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38408253/magnetically-powered-microwheel-thrombolysis-of-occlusive-thrombi-in-zebrafish
#30
JOURNAL ARTICLE
M Hao Hao Pontius, Chia-Jui Ku, Matthew J Osmond, Dante Disharoon, Yang Liu, Mark Warnock, Daniel A Lawrence, David W M Marr, Keith B Neeves, Jordan A Shavit
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for ischemic stroke but carries significant risks, including major hemorrhage. Additional options are needed, especially in small vessel thrombi which account for ~25% of ischemic strokes. We have previously shown that tPA-functionalized colloidal microparticles can be assembled into microwheels (µwheels) and manipulated under the control of applied magnetic fields to enable rapid thrombolysis of fibrin gels in microfluidic models of thrombosis...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38398946/marr-gan-memristive-attention-recurrent-residual-generative-adversarial-network-for-raindrop-removal
#31
JOURNAL ARTICLE
Qiuyue Chai, Yue Liu
Since machine learning techniques for raindrop removal have not been capable of completely removing raindrops and have failed to take into account the constraints of edge devices with limited resources, a novel software-hardware co-designed method with a memristor for raindrop removal, named memristive attention recurrent residual generative adversarial network (MARR-GAN), is introduced in this research. A novel raindrop-removal network is specifically designed based on attention gate connections and recurrent residual convolutional blocks...
January 31, 2024: Micromachines
https://read.qxmd.com/read/38396540/comparative-genome-analysis-of-two-streptococcus-suis-serotype-8-strains-identifies-two-new-virulence-associated-genes
#32
JOURNAL ARTICLE
Qi Sheng, Qiuhua Xu, Zouran Lan, Zongfu Wu
Streptococcus suis is an important zoonotic pathogen that can cause meningitis and septicemia in swine and humans. Among numerous pathogenic serotypes, S. suis serotype 8 has distinctive characteristics such as a high detection rate and causing multi-host infection. There is no complete genome of serotype 8 strains so far. In this study, the complete genome of two S. suis serotype 8 strains, virulent strain 2018WUSS151 and non-virulent strain WUSS030, were sequenced. Comparative genomic analysis showed that the homology of the two genomes reaches 99...
February 8, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38381627/marr-a-multi-agent-reinforcement-resetter-for-redirected-walking
#33
JOURNAL ARTICLE
Ho Jung Lee, Sang-Bin Jeon, Yong-Hun Cho, In-Kwon Lee
The reset technique of Redirected Walking (RDW) forcibly reorients the user's direction overtly to avoid collisions with boundaries, obstacles, or other users in the physical space. However, excessive resetting can decrease the user's sense of immersion and presence. Several RDW studies have been conducted to address this issue. Among them, much research has been done on reset techniques that reduce the number of resets by devising reset direction rules or optimizing them for a given environment. However, existing optimization studies on reset techniques have mainly focused on a single-user environment...
February 21, 2024: IEEE Transactions on Visualization and Computer Graphics
https://read.qxmd.com/read/38381244/pathological-calcification-in-canine-tendon-derived-cells-is-modulated-by-extracellular-atp
#34
JOURNAL ARTICLE
Danae E Zamboulis, Neil Marr, Alaa Moustafa, Richard Meeson, Isabel R Orriss, Chavaunne T Thorpe
Tendon calcification is a commonly associated with degenerative tendinopathy of the Achilles tendons in dogs. It is characterised by the formation of calcific deposits and is refractory to treatment, often re-forming after surgical removal. Little is known about its pathogenesis and therefore the aims of this study were to develop an in vitro model of canine tendon calcification and use this model to investigate mechanisms driving calcification. Cells from the canine Achilles tendon were cultured with different calcifying media to establish which conditions were best able to induce specific, cell-mediated calcification...
February 21, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38378610/feeling-safer-effectiveness-feasibility-and-acceptability-of-continuous-pulse-oximetry-for-people-who-smoke-opioids-at-overdose-prevention-services-in-british-columbia-canada
#35
JOURNAL ARTICLE
Jessica Moe, Tamara Chavez, Charotte Marr, Fred Cameron, Damian Feldman-Kiss, Yueqiao Elle Wang, Jessica C Xavier, Zahra Mamdani, Roy A Purssell, Amy Salmon, Jane A Buxton
BACKGROUND: Smoking is the most common mode of unregulated opioid consumption overall and implicated in fatal overdoses in British Columbia (BC). In part, perception of decreased risk (e.g., fewer who smoke carry naloxone kits) and limited smoking-specific harm reduction services contribute to overdose deaths. Overdose prevention services (OPS) offer supervised settings for drug use. Continuous pulse oximetry, common in acute care, allows real-time, remote oxygen monitoring. We evaluated the effectiveness of a novel continuous pulse oximetry protocol aimed at allowing physical distancing (as required by COVID-19, secluded spaces, and to avoid staff exposure to vaporized opioids), its feasibility, and acceptability at OPS for people who smoke opioids...
February 20, 2024: Harm Reduction Journal
https://read.qxmd.com/read/38376083/ultrasound-verification-of-plaque-brachytherapy-placement-in-patients-treated-for-primary-uveal-melanoma-a-single-center-experience
#36
JOURNAL ARTICLE
Joseph M Grimes, Henry Zhou, Alexis K Dal Col, Alexandra Gershkovich, Dmitry Bogomolny, Brian P Marr
INTRODUCTION: Proper plaque positioning is essential for effective episcleral plaque brachytherapy and can be verified using ultrasound. In this study, we show our center's protocol for intraoperative ultrasound verification of plaque placement and present our single-center local recurrence data in patients with primary UM involving the choroid and/or ciliary body. We also indicate our center's distance metastasis rate for patients presenting with primary UM. METHODS: All patients who presented to our institution with UM of the choroid and/or ciliary body between May 2017 and March 2022 and treated with plaque brachytherapy were enrolled...
August 2023: Ocular Oncology and Pathology
https://read.qxmd.com/read/38375856/casting-elastic-intramedullary-nailing-or-external-fixation-in-pediatric-tibial-shaft-fractures-which-is-the-most-appropriate-treatment-a-multicenter-study
#37
JOURNAL ARTICLE
Lorenza Marengo, Emilio Enrietti, Melissa Piccinno, Luca Ceroni, Giorgio Marre' Brunenghi, Silvio Boero, Antonio Colella, Daniela Dibello
The main objective of this study was to retrospectively evaluate and compare the outcomes and complications of displaced closed tibial fractures in children treated by CRC (closed reduction and casting), elastic stable intramedullary nailing (ESIN) or external fixation (EF). One hundred twenty-three consecutive children were treated for displaced closed tibia shaft fracture from July 2014 and January 2020 at two different institutions. Seventy-five of them met the inclusion criteria and were included in the study: 30 (40%) patients were treated with CRC, 33 (44%) with ESIN, and 12 with EF (16%)...
February 19, 2024: Journal of Pediatric Orthopedics. Part B
https://read.qxmd.com/read/38374263/generation-of-complex-bone-marrow-organoids-from-human-induced-pluripotent-stem-cells
#38
JOURNAL ARTICLE
Stephanie Frenz-Wiessner, Savannah D Fairley, Maximilian Buser, Isabel Goek, Kirill Salewskij, Gustav Jonsson, David Illig, Benedicta Zu Putlitz, Daniel Petersheim, Yue Li, Pin-Hsuan Chen, Martina Kalauz, Raffaele Conca, Michael Sterr, Johanna Geuder, Yoko Mizoguchi, Remco T A Megens, Monika I Linder, Daniel Kotlarz, Martina Rudelius, Josef M Penninger, Carsten Marr, Christoph Klein
The human bone marrow (BM) niche sustains hematopoiesis throughout life. We present a method for generating complex BM-like organoids (BMOs) from human induced pluripotent stem cells (iPSCs). BMOs consist of key cell types that self-organize into spatially defined three-dimensional structures mimicking cellular, structural and molecular characteristics of the hematopoietic microenvironment. Functional properties of BMOs include the presence of an in vivo-like vascular network, the presence of multipotent mesenchymal stem/progenitor cells, the support of neutrophil differentiation and responsiveness to inflammatory stimuli...
February 19, 2024: Nature Methods
https://read.qxmd.com/read/38363432/recombinant-ifn-%C3%AE-1b-treatment-in-a-patient-with-inherited-ifn-%C3%AE-deficiency
#39
JOURNAL ARTICLE
Jérémie Rosain, Ayca Kiykim, Alexandre Michev, Yasemin Kendir-Demirkol, Darawan Rinchai, Jessica N Peel, Hailun Li, Suheyla Ocak, Pinar Gokmirza Ozdemir, Tom Le Voyer, Quentin Philippot, Taushif Khan, Anna-Lena Neehus, Mélanie Migaud, Camille Soudée, Stéphanie Boisson-Dupuis, Nico Marr, Alessandro Borghesi, Jean-Laurent Casanova, Jacinta Bustamante
PURPOSE: Inborn errors of IFN-γ immunity underlie Mendelian susceptibility to mycobacterial disease (MSMD). Twenty-two genes with products involved in the production of, or response to, IFN-γ and variants of which underlie MSMD have been identified. However, pathogenic variants of IFNG encoding a defective IFN-γ have been described in only two siblings, who both underwent hematopoietic stem cell transplantation (HCST). METHODS: We characterized a new patient with MSMD by genetic, immunological, and clinical means...
February 16, 2024: Journal of Clinical Immunology
https://read.qxmd.com/read/38352867/design-of-a-targeted-blood-transcriptional-panel-for-monitoring-immunological-changes-accompanying-pregnancy
#40
JOURNAL ARTICLE
Tobias Brummaier, Darawan Rinchai, Mohammed Toufiq, Mohammed Y Karim, Tanwir Habib, Jürg Utzinger, Daniel H Paris, Rose McGready, Alexandra K Marr, Tomoshige Kino, Annalisa Terranegra, Souhaila Al Khodor, Damien Chaussabel, Basirudeen Syed Ahamed Kabeer
BACKGROUND: Immunomodulatory processes exert steering functions throughout pregnancy. Detecting diversions from this physiologic immune clock may help identify pregnant women at risk for pregnancy-associated complications. We present results from a data-driven selection process to develop a targeted panel of mRNAs that may prove effective in detecting pregnancies diverting from the norm. METHODS: Based on a de novo dataset from a resource-constrained setting and a dataset from a resource-rich area readily available in the public domain, whole blood gene expression profiles of uneventful pregnancies were captured at multiple time points during pregnancy...
2024: Frontiers in Immunology
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