keyword
MENU ▼
Read by QxMD icon Read
search

MarR

keyword
https://www.readbyqxmd.com/read/28334115/faster-a-user-friendly-tool-for-ultrafast-and-robust-cell-segmentation-in-large-scale-microscopy
#1
Oliver Hilsenbeck, Michael Schwarzfischer, Dirk Loeffler, Sotiris Dimopoulos, Simon Hastreiter, Carsten Marr, Fabian J Theis, Timm Schroeder
Motivation: Quantitative large-scale cell microscopy is widely used in biological and medical research. Such experiments produce huge amounts of image data and thus require automated analysis. However, automated detection of cell outlines (cell segmentation) is typically challenging due to, e.g., high cell densities, cell-to-cell variability and low signal-to-noise ratios. Results: Here, we evaluate accuracy and speed of various state-of-the-art approaches for cell segmentation in light microscopy images using challenging real and synthetic image data...
February 22, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28327925/abvd-chemotherapy-with-reduced-radiation-therapy-rates-in-children-adolescents-and-young-adults-with-all-stages-of-hodgkin-lymphoma
#2
K C Marr, J M Connors, K J Savage, K J Goddard, R J Deyell
Background: We adopted ABVD chemotherapy with risk-adapted radiation therapy (RT) as first-line therapy for children, adolescents and young adults with Hodgkin lymphoma (HL) in British Columbia (BC) in 2004. Patients and Methods: Patients ≤ 25 years diagnosed from 2004 to 2013 with all stages of HL who received ABVD as initial therapy were included. Results: Among 55 children (age < 18 y) and 154 young adults (18-25 y) there were no significant differences between age groups for sex, histologic subtype, tumour bulk, B symptoms, prognostic risk groups or treatment received...
March 6, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28319658/moisture-mediated-interactions-between-amorphous-maltodextrins-and-crystalline-fructose
#3
Alpana Thorat, Krystin N Marrs, Mohamed K Ghorab, Vincent Meunier, Laurent Forny, Lynne S Taylor, Lisa J Mauer
The effects of coformulating amorphous maltodextrins (MDs) and crystalline fructose, a deliquescent solid, on the moisture sorption, deliquescence point (RH0 ), and glass transition temperature (Tg ) behaviors were determined. Moisture sorption profiles of binary fructose:MD mixtures and individual ingredients were generated using controlled relative humidity (RH) desiccators and by dynamic vapor sorption techniques. Blends exhibited synergistic moisture uptake at RHs below the RH0 of fructose, attributed to partial dissolution of fructose in plasticized MD matrices without a significant reduction in the RH0 of the undissolved fructose...
March 20, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28318267/magnetic-microlassos-for-reversible-cargo-capture-transport-and-release
#4
Tao Yang, Tonguc Onur Tasci, Keith B Neeves, Ning Wu, David W M Marr
Microbot propulsion has seen increasing interest in recent years as artificial methods that overcome the well-established reversible and challenging nature of microscale fluid mechanics. While controlled movement is an important feature of microbot action, many envisioned applications also involve cargo transport where microbots must be able to load and unload contents on command while tolerating complex solution chemistry. Here we introduce a physical method that uses flexible and linked superparamagnetic colloidal chains, which can form closed rings or "lassos" in the presence of a planar rotating magnetic field...
March 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28315754/hepatitis-b-and-htlv-1-co-infection-in-the-northern-territory-australia
#5
Ian Marr, Jane Davies, Rob W Baird
OBJECTIVE: To establish the relationship of Hepatitis B and HTLV-1 serological markers in the Northern Territory, Australia. METHODS: A retrospective serological study of patients, presenting to public healthcare facilities, in the Northern Territory between 2008 and 2015, was performed to determine presence and relationships of serological markers of Hepatitis B virus (HBV), and Human T-cell Leukemic virus 1 (HTLV-1). RESULTS: There were 740 individual cases of serological positive HTLV-1 identified over 8 years in the Northern Territory...
March 15, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28285267/angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-in-high-vascular-risk
#6
Louis Potier, Ronan Roussel, Yedid Elbez, Michel Marre, Uwe Zeymer, Christopher M Reid, Magnus Ohman, Kim A Eagle, Deepak L Bhatt, Philippe Gabriel Steg
OBJECTIVE: ACE inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are widely prescribed in patients with high cardiovascular (CV) risk. However, whether both classes have equivalent effectiveness to prevent CV events remains unclear. The aim of this study was to compare the incidence of major CV events between ACEI and ARB users. METHODS: The Reduction of Atherothrombosis for Continued Health registry is an observational study who enrolled 69 055 individuals with high CV risk...
March 11, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28264705/improved-molecular-detection-of-babesia-infections-in-animals-using-a-novel-quantitative-real-time-pcr-diagnostic-assay-targeting-mitochondrial-dna
#7
Barbara A Qurollo, Nikole R Archer, Megan E Schreeg, Henry S Marr, Adam J Birkenheuer, Kaitlin N Haney, Brittany S Thomas, Edward B Breitschwerdt
BACKGROUND: Babesiosis is a protozoal, tick transmitted disease found worldwide in humans, wildlife and domesticated animals. Commonly used approaches to diagnose babesiosis include microscopic examination of peripheral blood smears, detection of circulating antibodies and PCR. To screen and differentiate canine Babesia infections many PCR assays amplify the 18S rRNA gene. These sequences contain hypervariable regions flanked by highly conserved regions allowing for amplification of a broad-range of Babesia spp...
March 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28263793/recent-progress-in-multi-electrode-spike-sorting-methods
#8
REVIEW
Baptiste Lefebvre, Pierre Yger, Olivier Marre
In recent years, arrays of extracellular electrodes have been developed and manufactured to record simultaneously from hundreds of electrodes packed with a high density. These recordings should allow neuroscientists to reconstruct the individual activity of the neurons spiking in the vicinity of these electrodes, with the help of signal processing algorithms. Algorithms need to solve a source separation problem, also known as spike sorting. However, these new devices challenge the classical way to do spike sorting...
March 2, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28245532/volume-and-density-of-microglomeruli-in-the-honey-bee-mushroom-bodies-do-not-predict-performance-on-a-foraging-task
#9
Byron N Van Nest, Ashley E Wagner, Glen S Marrs, Susan E Fahrbach
The mushroom bodies (MBs) are insect brain regions important for sensory integration, learning, and memory. In adult worker honey bees (Apis mellifera), the volume of neuropil associated with the MBs is larger in experienced foragers compared with hive bees and less experienced foragers. In addition, the characteristic synaptic structures of the calycal neuropils, the microglomeruli, are larger but present at lower density in 35-day-old foragers relative to 1-day-old workers. Age- and experience-based changes in plasticity of the MBs are assumed to support performance of challenging tasks, but the behavioral consequences of brain plasticity in insects are rarely examined...
February 28, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28228143/relationship-between-salivary-pancreatic-amylase-and-body-mass-index-a-systems-biology-approach
#10
Amélie Bonnefond, Loïc Yengo, Aurélie Dechaume, Mickaël Canouil, Maxime Castelain, Estelle Roger, Frédéric Allegaert, Robert Caiazzo, Violeta Raverdy, Marie Pigeyre, Abdelilah Arredouani, Jean-Michel Borys, Claire Lévy-Marchal, Jacques Weill, Ronan Roussel, Beverley Balkau, Michel Marre, François Pattou, Thierry Brousseau, Philippe Froguel
BACKGROUND: Salivary (AMY1) and pancreatic (AMY2) amylases hydrolyze starch. Copy number of AMY1A (encoding AMY1) was reported to be higher in populations with a high-starch diet and reduced in obese people. These results based on quantitative PCR have been challenged recently. We aimed to re-assess the relationship between amylase and adiposity using a systems biology approach. METHODS: We assessed the association between plasma enzymatic activity of AMY1 or AMY2, and several metabolic traits in almost 4000 French individuals from D...
February 23, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28221373/ecological-restoration-soil-microbes-call-the-shots
#11
Robert H Marrs
No abstract text is available yet for this article.
August 2, 2016: Nature Plants
https://www.readbyqxmd.com/read/28218899/prospective-identification-of-hematopoietic-lineage-choice-by-deep-learning
#12
Felix Buggenthin, Florian Buettner, Philipp S Hoppe, Max Endele, Manuel Kroiss, Michael Strasser, Michael Schwarzfischer, Dirk Loeffler, Konstantinos D Kokkaliaris, Oliver Hilsenbeck, Timm Schroeder, Fabian J Theis, Carsten Marr
Differentiation alters molecular properties of stem and progenitor cells, leading to changes in their shape and movement characteristics. We present a deep neural network that prospectively predicts lineage choice in differentiating primary hematopoietic progenitors using image patches from brightfield microscopy and cellular movement. Surprisingly, lineage choice can be detected up to three generations before conventional molecular markers are observable. Our approach allows identification of cells with differentially expressed lineage-specifying genes without molecular labeling...
February 20, 2017: Nature Methods
https://www.readbyqxmd.com/read/28203054/uveal-melanoma-epidemiology-etiology-and-treatment-of-primary-disease
#13
REVIEW
Benjamin A Krantz, Nikita Dave, Kimberly M Komatsubara, Brian P Marr, Richard D Carvajal
Uveal melanoma (UM) is the most common intraocular malignancy and arises from melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is crucial, as survival correlates with primary tumor size. However, approximately 50% of patients will develop metastatic disease with 6-12 months' survival from metastatic diagnosis. Genomic analyses have led to the development of gene-expression profiles that effectively predict metastatic progression; unfortunately, no adjuvant therapy has been shown to prolong survival to date...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28198357/cgcorrect-a-method-to-correct-for-confounding-cell-cell-variation-due-to-cell-growth-in-single-cell-transcriptomics
#14
Thomas Blasi, Florian Buettner, Michael Strasser, Carsten Marr, Fabian Theis
MOTIVATION: Accessing gene expression at the single cell level has unraveled often large heterogeneity among seemingly homogeneous cells, which remained obscured in traditional population based approaches. The computational analysis of single-cell transcriptomics data, however, still imposes unresolved challenges with respect to normalization, visualization and modeling the data. One such issue are differences in cell size, which introduce additional variability into the data, for which appropriate normalization techniques are needed...
February 15, 2017: Physical Biology
https://www.readbyqxmd.com/read/28197133/metatranscriptomics-reveals-the-active-bacterial-and-eukaryotic-fibrolytic-communities-in-the-rumen-of-dairy-cow-fed-a-mixed-diet
#15
Sophie Comtet-Marre, Nicolas Parisot, Pascale Lepercq, Frédérique Chaucheyras-Durand, Pascale Mosoni, Eric Peyretaillade, Ali R Bayat, Kevin J Shingfield, Pierre Peyret, Evelyne Forano
Ruminants have a unique ability to derive energy from the degradation of plant polysaccharides through the activity of the rumen microbiota. Although this process is well studied in vitro, knowledge gaps remain regarding the relative contribution of the microbiota members and enzymes in vivo. The present study used RNA-sequencing to reveal both the expression of genes encoding carbohydrate-active enzymes (CAZymes) by the rumen microbiota of a lactating dairy cow and the microorganisms forming the fiber-degrading community...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28176463/severe-chronic-norovirus-diarrheal-disease-in-transplant-recipients-clinical-features-of-an-under-recognized-syndrome
#16
Robin K Avery, Bonnie E Lonze, Edward S Kraus, Kieren A Marr, Robert A Montgomery
BACKGROUND: Norovirus (NV) infection has been reported as a cause of severe chronic diarrhea in transplant recipients, but this entity remains under-recognized in clinical practice, leading to diagnostic delays. Transplant clinicians should become familiar with this syndrome in order to facilitate early detection and management. METHODS: Demographic, clinical, and outcomes variables were summarized from a series of transplant recipients with positive stool NV reverse transcription polymerase chain reaction (RT-PCR) assays at Johns Hopkins in 2013-2014...
February 7, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28174115/antioxidant-and-antigenotoxic-potential-of-ramaria-largentii-marr-d-e-stuntz-a-wild-edible-mushroom-collected-from-northeast-romania
#17
Ana Clara Aprotosoaie, Daniela Elena Zavastin, Cosmin-Teodor Mihai, Gabriela Voichita, Daniela Gherghel, Mihaela Silion, Adriana Trifan, Anca Miron
Ramaria largentii Marr & D. E. Stuntz (orange coral mushroom) is a wild edible mushroom whose chemical composition and bioactivity have not been investigated. Herein, we present a study on the phenolic constituents, antioxidant and antigenotoxic effects of a hydromethanolic extract of the fruiting bodies. Total phenolic content, estimated by Folin-Ciocalteu assay, was found to be 42.33 ± 0.18 mg GAE/g. Protocatechuic and vanillic acids were detected by HPLC-DAD-ESI-MS. The extract showed good free radical scavenging and reducing capacities (EC50 = 64...
February 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28169881/side-effects-and-tolerability-of-combination-blood-pressure-lowering-according-to-blood-pressure-levels-an-analysis-of-the-perindopril-protection-against-recurrent-stroke-study-and-action-in-diabetes-and-vascular-disease-preterax-and-diamicron-mr-controlled
#18
Emily R Atkins, Yoichiro Hirakawa, Abdul Salam, Mark Woodward, Mark Cooper, Pavel Hamet, Stephen Harrap, Kennedy Lees, Lisheng Liu, Giuseppe Mancia, Michel Marre, Vlado Perkovic, Neil Poulter, Bryan Williams, John Chalmers, Anthony Rodgers
OBJECTIVE: To measure the placebo-controlled effects of combination therapy on hypotension, treatment discontinuation, and major renal outcomes, according to baseline blood pressure. METHODS: We conducted an analysis of the action in diabetes and vascular disease: preterax and diamicron-MR controlled evaluation and perindopril protection against recurrent stroke study trials, including 14 684 participants allocated combination therapy or placebo. The mean age was 65 years, 61% were men, and 64% were receiving background blood pressure lowering (BPL) therapy...
February 6, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28165464/genome-wide-association-analysis-implicates-dysregulation-of-immunity-genes-in-chronic-lymphocytic-leukaemia
#19
Philip J Law, Sonja I Berndt, Helen E Speedy, Nicola J Camp, Georgina P Sava, Christine F Skibola, Amy Holroyd, Vijai Joseph, Nicola J Sunter, Alexandra Nieters, Silvia Bea, Alain Monnereau, David Martin-Garcia, Lynn R Goldin, Guillem Clot, Lauren R Teras, Inés Quintela, Brenda M Birmann, Sandrine Jayne, Wendy Cozen, Aneela Majid, Karin E Smedby, Qing Lan, Claire Dearden, Angela R Brooks-Wilson, Andrew G Hall, Mark P Purdue, Tryfonia Mainou-Fowler, Claire M Vajdic, Graham H Jackson, Pierluigi Cocco, Helen Marr, Yawei Zhang, Tongzhang Zheng, Graham G Giles, Charles Lawrence, Timothy G Call, Mark Liebow, Mads Melbye, Bengt Glimelius, Larry Mansouri, Martha Glenn, Karen Curtin, W Ryan Diver, Brian K Link, Lucia Conde, Paige M Bracci, Elizabeth A Holly, Rebecca D Jackson, Lesley F Tinker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Marc Maynadie, James McKay, Demetrius Albanes, Stephanie Weinstein, Zhaoming Wang, Neil E Caporaso, Lindsay M Morton, Richard K Severson, Elio Riboli, Paolo Vineis, Roel C H Vermeulen, Melissa C Southey, Roger L Milne, Jacqueline Clavel, Sabine Topka, John J Spinelli, Peter Kraft, Maria Grazia Ennas, Geoffrey Summerfield, Giovanni M Ferri, Robert J Harris, Lucia Miligi, Andrew R Pettitt, Kari E North, David J Allsup, Joseph F Fraumeni, James R Bailey, Kenneth Offit, Guy Pratt, Henrik Hjalgrim, Chris Pepper, Stephen J Chanock, Chris Fegan, Richard Rosenquist, Silvia de Sanjose, Angel Carracedo, Martin J S Dyer, Daniel Catovsky, Elias Campo, James R Cerhan, James M Allan, Nathanial Rothman, Richard Houlston, Susan Slager
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(-13)), 1q42.13 (rs41271473, P=1.06 × 10(-10)), 4q24 (rs71597109, P=1.37 × 10(-10)), 4q35.1 (rs57214277, P=3...
February 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28155905/multipath-colourimetric-assay-for-copper-ii-ions-utilizing-marr-functionalized-gold-nanoparticles
#20
Yulong Wang, Limin Wang, Zhenhe Su, Juanjuan Xue, Jinbo Dong, Cunzheng Zhang, Xiude Hua, Minghua Wang, Fengquan Liu
We use the multiple antibiotic resistance regulator (MarR), as a highly selective biorecognition elements in a multipath colourimetric sensing strategy for the fast detection of Cu(2+) in water samples. The colourimetric assay is based on the aggregation of MarR-coated gold nanoparticles in the presence of Cu(2+) ions, which induces a red-to-purple colour change of the solution. The colour variation in the gold nanoparticle aggregation process can be used for qualitative and quantitative detection of Cu(2+) by the naked eye, and with UV-vis and smartphone-based approaches...
February 3, 2017: Scientific Reports
keyword
keyword
10602
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"