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David H Abramson, Armida W M Fabius, Jasmine H Francis, Brian P Marr, Ira J Dunkel, Scott E Brodie, Anna Escuder, Y Pierre Gobin
BACKGROUND: Surgical removal of one or both eyes has been the most common way to treat children with retinoblastoma worldwide for more than 100 years. Ophthalmic artery chemosurgery (OAC) was introduced 10 years ago and it has been used as an alternative to enucleation for eyes with advanced retinoblastoma. The purpose of this report is to analyze our 9-year experience treating advanced retinoblastoma eyes with OAC. MATERIALS AND METHODS: Single-arm retrospective study from a single center of 226 eyes with eyes of retinoblastoma patients with advanced intraocular disease defined as both Reese-Ellsworth (RE) "Va" or "Vb" and International Classification Retinoblastoma (ICRb) group "D" or "E" (COG Classification)...
January 17, 2017: Ophthalmic Genetics
Matthew D Karl, Jasmine H Francis, Saipriya Iyer, Brian Marr, David H Abramson
PURPOSE: To investigate the impact of intravitreal chemotherapy on intraocular pressure (IOP) in children with retinoblastoma. METHODS: This was a retrospective study of 10 eyes of 10 patients with retinoblastoma (7 males, 3 females, mean age: 33.6 ± 9.4 months) with vitreous seeding injected with intravitreal melphalan and topotecan. IOP was measured with Tono-pen (Reichert, Inc., Buffalo, NY) at baseline prior to injecting and then repeatedly following each intravitreal injection...
January 13, 2017: Journal of Pediatric Ophthalmology and Strabismus
Jasmine H Francis, Scott E Brodie, Brian Marr, Emily C Zabor, Ijah Mondesire-Crump, David H Abramson
PURPOSE: To investigate the efficacy and toxicity of intravitreous melphalan for treatment of retinoblastoma, as a single agent or with concomitant topotecan. PARTICIPANTS: A total of 130 eyes of 120 patients with retinoblastoma receiving 630 intravitreous (melphalan, topotecan) or topotecan periocular injections. A total of 83 (64%) of these eyes were treated with concomitant ophthalmic artery chemosurgery (OAC). DESIGN: Retrospective cohort study...
January 12, 2017: Ophthalmology
Guijie Liu, Xing Liu, Hongjiao Xu, Xichun Liu, Hu Zhou, Zhen Huang, Jianhua Gan, Hao Chen, Lefu Lan, Cai-Guang Yang
As a master redox-sensing MarR-family transcriptional regulator, AbfR participates in oxidative stress responses and virulence regulations in Staphylococcus epidermidis. Here, we present structural insights into the DNA-binding mechanism of AbfR in different oxidation states by determining the X-ray crystal structures of a reduced-AbfR/DNA complex, an overoxidized (Cys13-SO2H and Cys13-SO3H) AbfR/DNA, and 2-disulfide cross-linked AbfR dimer. Together with biochemical analyses, our results suggest that the redox regulation of AbfR-sensing displays two novel features: i) the reversible disulfide modification, but not the irreversible overoxidation, significantly abolishes the DNA-binding ability of the AbfR repressor; ii) either 1-disulfide cross-linked or 2-disulfide cross-linked AbfR dimer is biologically significant...
January 13, 2017: Journal of the American Chemical Society
G Matt Davies, Nicholas Kettridge, Cathelijne R Stoof, Alan Gray, Rob Marrs, Davide Ascoli, Paulo M Fernandes, Katherine A Allen, Stefan H Doerr, Gareth D Clay, Julia McMorrow, Vigdis Vandvik
No abstract text is available yet for this article.
November 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Thomas Curran, Fatima Abacha, Stephen Hibberd, Matthew Rolfe, Melissa Lacey, Jeffrey Green
SlyA is a member of the MarR family of bacterial transcriptional regulators. Previously, SlyA has been shown to directly regulate only two operons in Escherichia coli K-12 MG1655, fimB and hlyE (clyA). In both cases SlyA activates gene expression by antagonizing repression by the nucleoid associated protein H-NS. Here the transcript profiles of aerobic glucose-limited steady-state chemostat cultures of E. coli K-12 MG1655, slyA mutant and slyA over-expression strains are reported. The transcript profile of the slyA mutant was not significantly different to that of the parent; however, that of the slyA expression strain was significantly different from that of the vector control...
January 10, 2017: Microbiology
Erika Della Mina, Alessandro Borghesi, Hao Zhou, Salim Bougarn, Sabri Boughorbel, Laura Israel, Ilaria Meloni, Maya Chrabieh, Yun Ling, Yuval Itan, Alessandra Renieri, Iolanda Mazzucchelli, Sabrina Basso, Piero Pavone, Raffaele Falsaperla, Roberto Ciccone, Rosa Maria Cerbo, Mauro Stronati, Capucine Picard, Orsetta Zuffardi, Laurent Abel, Damien Chaussabel, Nico Marr, Xiaoxia Li, Jean-Laurent Casanova, Anne Puel
Most members of the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) families transduce signals via a canonical pathway involving the MyD88 adapter and the interleukin-1 receptor-associated kinase (IRAK) complex. This complex contains four molecules, including at least two (IRAK-1 and IRAK-4) active kinases. In mice and humans, deficiencies of IRAK-4 or MyD88 abolish most TLR (except for TLR3 and some TLR4) and IL-1R signaling in both leukocytes and fibroblasts. TLR and IL-1R responses are weak but not abolished in mice lacking IRAK-1, whereas the role of IRAK-1 in humans remains unclear...
January 9, 2017: Proceedings of the National Academy of Sciences of the United States of America
Supaporn Phanwilai, Chalermraj Wantawin, Akihiko Terada, Pongsak Lek Noophan, Junko Munakata-Marr
Anammox application for nutrient removal from wastewater is increasing, though questions remain about anammox resilience to fluctuating conditions. Resuscitation of anammox suspended- and attached-growth cultures after 3 months of starvation was studied with and without acetate dosing. Without acetate, the attached-growth culture recovered more quickly than the suspended-growth culture. Suspended-growth cultures recovered more quickly (within 60 days) with weekly and daily acetate dosing than without, but anammox activity and copy numbers decreased with continued acetate addition...
January 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Pavel Hamet, Mounsif Haloui, François Harvey, François-Christophe Marois-Blanchet, Marie-Pierre Sylvestre, Muhammad-Ramzan Tahir, Paul H G Simon, Beatriz Sonja Kanzki, John Raelson, Carole Long, John Chalmers, Mark Woodward, Michel Marre, Stephen Harrap, Johanne Tremblay
BACKGROUND: The prevalence of diabetic nephropathy varies according to ethnicity. Environmental as well as genetic factors contribute to the heterogeneity in the presentation of diabetic nephropathy. Our objective was to evaluate this heterogeneity within the Caucasian population. METHODS: The geo-ethnic origin of the 3409 genotyped Caucasian type 2 diabetes (T2D) patients of Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation was determined using principal component analysis...
January 5, 2017: Journal of Hypertension
Christopher J Stewart, Nicholas D Embleton, Emma C L Marrs, Daniel P Smith, Andrew Nelson, Bashir Abdulkadir, Tom Skeath, Joseph F Petrosino, John D Perry, Janet E Berrington, Stephen P Cummings
BACKGROUND: The preterm microbiome is crucial to gut health and may contribute to necrotising enterocolitis (NEC), which represents the most significant pathology affecting preterm infants. From a cohort of 318 infants, <32 weeks gestation, we selected 7 infants who developed NEC (defined rigorously) and 28 matched controls. We performed detailed temporal bacterial (n = 641) and metabolomic (n = 75) profiling of the gut microbiome throughout the disease. RESULTS: A core community of Klebsiella, Escherichia, Staphyloccocus, and Enterococcus was present in all samples...
December 29, 2016: Microbiome
Michael S Kelly, Joseph J Saseen, Joel C Marrs
OBJECTIVE: To determine whether patients who were newly prescribed antihypertensive therapy after the Eighth Joint National Committee (JNC 8) update were treated to a relaxed systolic blood pressure (SBP) goal compared with patients treated before the update. METHODS: A retrospective cohort study approved by the Colorado Multiple Institutional Review Board. Patients aged 60-79 years, without diabetes or chronic kidney disease (CKD), newly treated for hypertension at a University of Colorado primary care clinics were included...
February 2017: Therapeutic Advances in Cardiovascular Disease
Choongdeok Lee, Meong Il Kim, Minsun Hong
A phenolic acid decarboxylase (padC) regulator, PadR and its homologs proteins belong to the PadR family. Despite the growing numbers of the PadR family members and their various roles in bacteria, such as detoxifications, drug transports and circadian rhythms, biochemical and biophysical studies of the PadR family are very limited. Thus, a ligand-induced regulatory mechanism of the PadR family transcription factors remains to be elucidated. Here, we report a crystal structure of a Bacteroides fragilis PadR-like protein, BF2549 and revealed its interaction with putative operator DNA and ligand molecules...
December 24, 2016: Biochemical and Biophysical Research Communications
Deborah Marr
Evidence-based practice (EBP) is a widely endorsed concept, but many occupational therapy practitioners would like to be more informed and supported in its full implementation. They need information on the evolving definitions and concepts of EBP, encouragement to develop and adopt EBP models that link to occupational therapy's professional values, and methods that translate evidence into answers for clinical questions. This column discusses these needs and makes recommendations to the American Occupational Therapy Association for addressing them...
January 2017: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Ram Prosad Chakrabarty, Munawar Sultana, Saadlee Shehreen, Selina Akter, M Anwar Hossain
The study aims at revealing the comprehensive contribution of target alteration, target protection and efflux pump to the development of high level of ciprofloxacin (CIP) resistance in Enterobacteriaceae bacteria of environmental, clinical and poultry origins. Antibiotic susceptibility test was used to detect CIP resistant (CIPR) isolates and MICCIP was determined by broth microdilution method. The presence of qnrS gene was identified by PCR and Southern blot hybridization (SBH) confirmed their location. Checkerboard titration demonstrated the effect of NMP on CIP action...
December 2016: AMB Express
Paul W Groundwater, Rajeshwar Narlawar, Vivian Wan Yu Liao, Anusri Bhattacharya, Shalini Srivastava, Kishore Kunal, Munikumar Reddy Doddareddy, Pratik M Oza, Ramesh Reddy Mamidi, Emma Claire Louise Marrs, John David Perry, David E Hibbs, Dulal Panda
Inhibition of FtsZ assembly has been found to stall bacterial cell division. Here, we report the identification of a potent carbocyclic curcumin analogue, (2Z,6E)-2-{(E)-1-hydroxy-3-(4-hydroxyphenyl)allylidene}-6-(4-hydroxy-benzylidene)cyclohexanone (2d), that inhibits Bacillus subtilis 168 cell proliferation by targeting the assembly of FtsZ. 2d also showed potent inhibitory activity (MICs 2-4 mg/L) against several clinically important species of Gram positive bacteria, including methicillin-resistant Staphylococcus aureus...
December 21, 2016: Biochemistry
Swapnalee Sarmah, James A Marrs
Environmental pollution is a serious problem of the modern world that possesses a major threat to public health. Exposure to environmental pollutants during embryonic development is particularly risky. Although many pollutants have been verified as potential toxicants, there are new chemicals in the environment that need assessment. Heart development is an extremely sensitive process, which can be affected by environmentally toxic molecule exposure during embryonic development. Congenital heart defects are the most common life-threatening global health problems, and the etiology is mostly unknown...
December 16, 2016: International Journal of Molecular Sciences
J D Doecke, F Hartnell, P Bampton, S Bell, G Mahy, Z Grover, P Lewindon, L V Jones, K Sewell, K Krishnaprasad, R Prosser, D Marr, J Fischer, G R Thomas, J V Tehan, N S Ding, S E Cooke, K Moss, A Sechi, P De Cruz, R Grafton, S J Connor, I C Lawrance, R B Gearry, J M Andrews, G L Radford-Smith
BACKGROUND: Maintenance anti-tumour necrosis factor-α (anti-TNFα) treatment for Crohn's disease is the standard of care for patients with an inadequate response to corticosteroids and immunomodulators. AIM: To compare the efficacy and safety of infliximab and adalimumab in clinical practice and assess the value of concomitant immunomodulator therapy. METHODS: We performed an observational cohort study in consecutive patients with Crohn's disease qualifying for anti-TNFα treatment in Australia and New Zealand between 2007 and 2011...
February 2017: Alimentary Pharmacology & Therapeutics
Adam L Clayton, Shinichiro Enomoto, Yinghua Su, Colin Dale
Many bacteria utilize two-component systems consisting of a sensor kinase and a transcriptional response regulator to detect environmental signals and modulate gene expression for adaptation. The response regulator PhoP and its cognate sensor kinase PhoQ compose a two-component system known for its role in responding to low levels of Mg(2+) , Ca(2+) , pH, and to the presence of antimicrobial peptides and activating the expression of genes involved in adaptation to host association. Compared to their free-living relatives, mutualistic insect symbiotic bacteria inhabit a static environment where the requirement for sensory functions is expected to be relaxed...
December 17, 2016: Molecular Microbiology
Fabrice Bonnet, Amalia Gastaldelli, Florence Pihan-Le Bars, Andrea Natali, Ronan Roussel, John Petrie, Jean Tichet, Michel Marre, Bernard Fromenty, Beverley Balkau
OBJECTIVE: We hypothesized that liver markers and the fatty liver index (FLI) are predictive of incident hypertension and that hepatic insulin resistance plays a role. METHODS: The association between liver markers and incident hypertension was analysed in two longitudinal studies of normotensive individuals, 2565 from the 9-year data from an epidemiological study on the insulin resistance cohort and the 321 from the 3-year 'Relationship between Insulin Sensitivity and Cardiovascular disease' cohort who had a measure of endogenous glucose production...
December 14, 2016: Journal of Hypertension
C M Marr, R Morgan
No abstract text is available yet for this article.
January 2017: Equine Veterinary Journal
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