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https://www.readbyqxmd.com/read/29792196/ethnozoological-study-of-traditional-medicinal-appreciation-of-animals-and-their-products-among-the-indigenous-people-of-metema-woreda-north-western-ethiopia
#1
Fasil Adugna Kendie, Sileshi Andualem Mekuriaw, Melkamu Andargie Dagnew
BACKGROUND: Using animals for different purposes goes back to the dawn of mankind. Animals served as a source of food, medicine, and clothing for humans and provided other services. This study was designed to undertake a cross-sectional ethnozoological field survey among the residents of Metema Woreda from November 2015 to May 2016. METHODS: Data were collected through studied questionnaires, interviews, and focus group discussions with 36 purposively selected respondents...
May 23, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29790383/focal-treatment-for-unilateral-prostate-cancer-using-hifu-a-comprehensive-study-of-pooled-data
#2
Simone Albisinni, Christian Melot, Fouad Aoun, Ksenija Limani, Alexandre Peltier, Pascal Rischmann, Roland van Velthoven
BACKGROUND: Focal therapy for prostate cancer (PCa) remains experimental. Aim of the current study is to review available evidence and perform a pooled analysis exploring oncologic and functional results of High Intensity Focal Ultrasound (HIFU) focal therapy for the treatment of unilateral PCa. METHODS: The National Library of Medicine Database was searched for relevant articles. A wide search was performed including the combination of following words: "HIFU", "prostate", "cancer", "focal"...
May 23, 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29784973/significance-of-prohibitin-domain-family-in-tumorigenesis-and-its-implication-in-cancer-diagnosis-and-treatment
#3
Jie Yang, Bin Li, Qing-Yu He
Prohibitin (PHB) was originally isolated and characterized as an anti-proliferative gene in rat liver. The evolutionarily conserved PHB gene encodes two human protein isoforms with molecular weights of ~33 kDa, PHB1 and PHB2. PHB1 and PHB2 belong to the prohibitin domain family, and both are widely distributed in different cellular compartments such as the mitochondria, nucleus, and cell membrane. Most studies have confirmed differential expression of PHB1 and PHB2 in cancers compared to corresponding normal tissues...
May 21, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29779827/zika-virus-report-from-the-task-force-on-tropical-diseases-by-the-world-federation-of-societies-of-intensive-and-critical-care-medicine
#4
Gisele Sampaio Silva, Guy A Richards, Tim Baker, Jorge Hidalgo, Juan Ignacio Silesky Jiménez, Pravin Amin
Zika fever is an acute infectious disease caused by the Zika virus (ZIKV), an RNA virus belonging to the genus Flavivirus. ZIKV can be transmitted by bites from Aedes aegypti and Aedes albopictus species, sexual activity, blood transfusion and from mother to fetus during pregnancy and delivery. A total of 50 territories and countries in the Americas had reported ZIKV infections. For those with symptoms, the presentation is similar to dengue fever with body aches, joint pain, fatigue, malaise, fever and conjunctivitis lasting up to seven days...
April 5, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29777253/translation-inhibition-corrects-aberrant-localization-of-mutant-alanine-glyoxylate-aminotransferase-possible-therapeutic-approach-for-hyperoxaluria
#5
Ruth Belostotsky, Roman Lyakhovetsky, Michael Y Sherman, Fanny Shkedy, Shimrit Tzvi-Behr, Roi Bar, Bernd Hoppe, Björn Reusch, Bodo B Beck, Yaacov Frishberg
Primary hyperoxaluria type 1 is a severe kidney stone disease caused by abnormalities of the peroxisomal alanine-glyoxylate aminotransferase (AGT). The most frequent mutation G170R results in aberrant mitochondrial localization of the active enzyme. To evaluate the population of peroxisome-localized AGT, we developed a quantitative Glow-AGT assay based on the self-assembly split-GFP approach and used it to identify drugs that can correct mislocalization of the mutant protein. In line with previous reports, the Glow-AGT assay showed that mitochondrial transport inhibitors DECA and monensin increased peroxisomal localization of the mutant...
May 18, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29772618/-a-case-of-metastasis-of-cholangiocarcinoma-to-the-bladder
#6
Akiou Okumura, Akihiro Morii, Kiyoshi Takagawa, Hiroshi Kitamura
The patient was an 88-year-old male. He was referred to the Department of Internal Medicine because of total body itching and jaundice in July 2011. The serum bilirubin level was elevated, and the serum CA19-9 level was also elevated to 266. 6 U/ml. Computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) revealed a solid tumor between the hepatic hilus and common bile duct, and choler cytodiagnosis was class V ; adenocarcinoma. The patient was diagnosed with hilar cholangiocarcinoma and received conservative treatment with endoscopic nasobiliary drainage (ENBD) due to his advanced age...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29765296/peripartum-haemorrhage-haemostatic-aspects-of-the-new-german-pph-guideline
#7
REVIEW
Heiko Lier, Christian von Heymann, Wolfgang Korte, Dietmar Schlembach
Summary Peripartum haemorrhage remains one of the main causes of maternal mortality world-wide. The German, Austrian and Swiss Societies of Gynaecology and Obstetrics have updated the current guidelines for the treatment of peripartum haemorrhage together with the German Society of Anaesthesiology and Intensive Care Medicine and the Society of Thrombosis and Haemostasis Research. The recommendations have been the result of a thorough review of the available scientific literature and a consensus process involving all members of the guideline group...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29761688/collagenase-clostridium-histolyticum-a-novel-medical-treatment-for-peyronie-s-disease
#8
Amr Abdel Raheem, Mark Johnson, David Ralph, Giulio Garaffa
INTRODUCTION: Peyronie's disease (PD) affects up to 9% of the male population. PD causes scarring of the tunica albuginea of the penis which leads to penile deformity making sexual intercourse difficult or impossible. PD also causes significant psychological, emotional and relationship difficulties for both patient and partner. Up until the licencing of Collagenase clostridium histolyticum (CCH) (Xiapex®, Xiaflex®), surgical correction of the penile deformity was the mainstay of treatment...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29748819/recent-advances-in-steroidal-saponins-biosynthesis-and-in-vitro-production
#9
REVIEW
Swati Upadhyay, Gajendra Singh Jeena, Shikha, Rakesh Kumar Shukla
Steroidal saponins exhibited numerous pharmacological activities due to the modification of their backbone by different cytochrome P450s (P450) and UDP glycosyltransferases (UGTs). Plant-derived steroidal saponins are not sufficient for utilizing them for commercial purpose so in vitro production of saponin by tissue culture, root culture, embryo culture, etc, is necessary for its large-scale production. Saponin glycosides are the important class of plant secondary metabolites, which consists of either steroidal or terpenoidal backbone...
May 10, 2018: Planta
https://www.readbyqxmd.com/read/29747699/clinical-chronobiology-a-timely-consideration-in-critical-care-medicine
#10
REVIEW
Helen McKenna, Gijsbertus T J van der Horst, Irwin Reiss, Daniel Martin
A fundamental aspect of human physiology is its cyclical nature over a 24-h period, a feature conserved across most life on Earth. Organisms compartmentalise processes with respect to time in order to promote survival, in a manner that mirrors the rotation of the planet and accompanying diurnal cycles of light and darkness. The influence of circadian rhythms can no longer be overlooked in clinical settings; this review provides intensivists with an up-to-date understanding of the burgeoning field of chronobiology, and suggests ways to incorporate these concepts into daily practice to improve patient outcomes...
May 11, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29746995/rising-trade-declining-stocks-the-global-gugul-commiphora-wightii-trade
#11
REVIEW
A B Cunningham, J A Brinckmann, R N Kulloli, U Schippmann
ETHNOPHARMACOLOGICAL RELEVANCE: Commiphora wightii is exploited in India and Pakistan for an oleo-resin (gum guggul) traditionally used in Ayurvedic, Siddha and Unani medical systems. Processed C. wightii oleo-resin products are exported from India to 42 countries, including re-export to Pakistan, for anti-inflammatory use and as an anti-inflammatory and an anti-obesity treatment considered to lower cholesterol and lipid levels. The C. wightii export trade has particular relevance to the European Union because Belgium, France, Germany, Hungary, Italy, the Netherlands, and United Kingdom are importing countries...
May 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29746899/ncs-1-is-a-regulator-of-calcium-signaling-in-health-and-disease
#12
REVIEW
Göran R Boeckel, Barbara E Ehrlich
Neuronal Calcium Sensor-1 (NCS-1) is a highly conserved calcium binding protein which contributes to the maintenance of intracellular calcium homeostasis and regulation of calcium-dependent signaling pathways. It is involved in a variety of physiological cell functions, including exocytosis, regulation of calcium permeable channels, neuroplasticity and response to neuronal damage. Over the past 30 years, continuing investigation of cellular functions of NCS-1 and associated disease states have highlighted its function in the pathophysiology of several disorders and as a therapeutic target...
May 7, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29745863/generation-and-comparative-genomics-of-synthetic-dengue-viruses
#13
Eli Goz, Yael Tsalenchuck, Rony Oren Benaroya, Zohar Zafrir, Shimshi Atar, Tahel Altman, Justin Julander, Tamir Tuller
BACKGROUND: Synthetic virology is an important multidisciplinary scientific field, with emerging applications in biotechnology and medicine, aiming at developing methods to generate and engineer synthetic viruses. In particular, many of the RNA viruses, including among others the Dengue and Zika, are widespread pathogens of significant importance to human health. The ability to design and synthesize such viruses may contribute to exploring novel approaches for developing vaccines and virus based therapies...
May 8, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29743921/use-and-conservation-of-medicinal-plants-by-indigenous-people-of-gozamin-wereda-east-gojjam-zone-of-amhara-region-ethiopia-an-ethnobotanical-approach
#14
Nigussie Amsalu, Yilkal Bezie, Mulugeta Fentahun, Addisu Alemayehu, Gashaw Amsalu
An ethnobotanical study of medicinal plants (MPs) used by the local community has been carried out from January 5, 2014, to February 15, 2015, in Gozamin Wereda of East Gojjam Zone, Ethiopia. The purpose of this study was to identify and document the use and conservation of MPs, along with indigenous knowledge of Gozamin community. Data were collected using semistructured interview, field observation, and focus group discussions. The collected data were assessed quantitatively using fidelity level, Jaccard's Coefficient of Similarity, paired comparisons, direct matrix, and preference rankings...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29739980/systematic-analysis-of-demeter-like-dna-glycosylase-genes-shows-lineage-specific-smi-mir7972-involved-in-smdml1-regulation-in-salvia-miltiorrhiza
#15
Jiang Li, Caili Li, Shanfa Lu
DEMETER-like DNA glycosylases (DMLs) initiate the base excision repair-dependent DNA demethylation to regulate a wide range of biological processes in plants. Six putative SmDML genes, termed SmDML1-SmDML6, were identified from the genome of S. miltiorrhiza, an emerging model plant for Traditional Chinese Medicine (TCM) studies. Integrated analysis of gene structures, sequence features, conserved domains and motifs, phylogenetic analysis and differential expression showed the conservation and divergence of SmDMLs...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29736568/emerging-concepts-in-treating-cartilage-osteochondral-defects-and-osteoarthritis-of-the-knee-and-ankle
#16
Hélder Pereira, Ibrahim Fatih Cengiz, Carlos Vilela, Pedro L Ripoll, João Espregueira-Mendes, J Miguel Oliveira, Rui L Reis, C Niek van Dijk
The management and treatment of cartilage lesions, osteochondral defects, and osteoarthritis remain a challenge in orthopedics. Moreover, these entities have different behaviors in different joints, such as the knee and the ankle, which have inherent differences in function, biology, and biomechanics. There has been a huge development on the conservative treatment (new technologies including orthobiologics) as well as on the surgical approach. Some surgical development upraises from technical improvements including advanced arthroscopic techniques but also from increased knowledge arriving from basic science research and tissue engineering and regenerative medicine approaches...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29734654/the-novel-mirna-n-72-regulates-egf-induced-migration-of-human-amnion-mesenchymal-stem-cells-by-targeting-mmp2
#17
Ying Li, Dianbao Zhang, Meng Chen, Rui Wang, Tao Zhang, Feng Zhao, Xuewen Lin, Xining Pang
Human amnion mesenchymal stem cells (hAMSCs) are promising sources of stem cells in regenerative medicine. The migration stimulated by cytokines is critical for mesenchymal stem cells (MSCs)-based cytotherapy, while the regulatory mechanisms of EGF (epidermal growth factor)-induced hAMSC migration are largely unclear. Here, a novel miRNA N-72 (GenBank accession number: MH269369) has been discovered, and its function on EGF-induced migration in hAMSCs was investigated. High-purity hAMSCs were isolated and cultured in vitro, which were characterized by flow cytometry and trilineage differentiation...
May 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29734406/-cryo-conservation-of-ajania-pacifica-nakai-bremer-et-humphries-shoot-tips-via-encapsulation-dehydration-technique
#18
D Kulus, A Abratowska
  BACKGROUND: Ajania pacifica, a novelty on the horticultural market, is valued as an ornamental and a medicinal plant. Breeding programs led to the creation of numerous cultivars. Therefore, it is important to develop species storage methods. OBJECTIVE: The aim of this study has been to develop an encapsulation-based cryopreservation protocol of Ajania pacifica shoot tips. MATERIALS AND METHODS: Shoot tips of ajania 'Bengo' were precultured on media with different sucrose and ABA concentrations, encapsulated and dehydrated for various periods and stored in liquid nitrogen...
September 2017: Cryo Letters
https://www.readbyqxmd.com/read/29728134/ethnobotany-of-the-sierra-nevada-del-cocuy-g%C3%A3-ic%C3%A3-n-climate-change-and-conservation-strategies-in-the-colombian-andes
#19
Mireia Alcántara Rodríguez, Andrea Angueyra, Antoine M Cleef, Tinde Van Andel
BACKGROUND: The Sierra Nevada del Cocuy-Güicán in the Colombian Andes is protected as a National Natural Park since 1977 because of its fragile páramo ecosystems, extraordinary biodiversity, high plant endemism, and function as water reservoir. The vegetation on this mountain is threatened by expanding agriculture, deforestation, tourism, and climate change. We present an ethnobotanical inventory among local farmer communities and discuss the effects of vegetation change on the availability of useful plants...
May 5, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29728034/-development-of-indel-markers-for-molecular-authentication-of-panax-ginseng-and-p-quinquefolius
#20
Rong-Bo Wang, Hui-Li Tian, Hong-Tao Wang, Gui-Sheng Li
Panax ginseng and P. quinquefolius are two kinds of important medicinal herbs. They are morphologically similar but have different pharmacological effects. Therefore, botanical origin authentication of these two ginsengs is of great importance for ensuring pharmaceutical efficacy and food safety. Based on the fact that intron position in orthologous genes is highly conserved across plant species, intron length polymorphisms were exploited from unigenes of ginseng. Specific primers were respectively designed for these two species based on their insertion/deletion sequences of cytochrome P450 and glyceraldehyde 3-phosphate dehydrogenase, and multiplex PCR was conducted for molecular authentication of P...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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