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https://www.readbyqxmd.com/read/29339095/patterning-the-gastrointestinal-epithelium-to-confer-regional-specific-functions
#1
REVIEW
Cayla A Thompson, Ann DeLaForest, Michele A Battle
The gastrointestinal (GI) tract, in simplest terms, can be described as an epithelial-lined muscular tube extending along the cephalocaudal axis from the oral cavity to the anus. Although the general architecture of the GI tract organs is conserved from end to end, the presence of different epithelial tissue structures and unique epithelial cell types within each organ enables each to perform the distinct digestive functions required for efficient nutrient assimilation. Spatiotemporal regulation of signaling pathways and downstream transcription factors controls GI epithelial morphogenesis during development to confer essential regional-specific epithelial structures and functions...
January 12, 2018: Developmental Biology
https://www.readbyqxmd.com/read/29334976/plants-traditionally-used-to-make-cantonese-slow-cooked-soup-in-china
#2
Yujing Liu, Qi Liu, Ping Li, Deke Xing, Huagang Hu, Lin Li, Xuechen Hu, Chunlin Long
BACKGROUND: Lǎo huǒ liàng tāng (Cantonese slow-cooked soup, CSCS) is popular in Guangdong, China, and is consumed by Cantonese people worldwide as a delicious appetizer. Because CSCS serves as an important part of family healthcare, medicinal plants and plant-derived products are major components of CSCS. However, a collated record of the diverse plant species and an ethnobotanical investigation of CSCS is lacking. Because of globalization along with a renewed interest in botanical and food therapy, CSCS has attracted a growing attention in soup by industries, scientists, and consumers...
January 15, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29333379/broccoli-brassica-oleracea-reduces-oxidative-damage-to-pancreatic-tissue-and-combats-hyperglycaemia-in-diabetic-rats
#3
Sithara Suresh, Mostafa Ibrahim Waly, Mohammad Shafiur Rahman, Nejib Guizani, Mohamed Abdullah Badar Al-Kindi, Halima Khalfan Ahmed Al-Issaei, Sultan Nasser Mohd Al-Maskari, Bader Rashid Said Al-Ruqaishi, Ahmed Al-Salami
Oxidative stress plays a pivotal role in the development of diabetes and hyperglycaemia. The protective effects of natural extracts against diabetes are mainly dependent on their antioxidant and hypoglycaemic properties. Broccoli (Brassica oleracea) exerts beneficial health effects in several diseases including diabetes; however, the mechanism has not been elucidated yet. The present study was carried out to evaluate the potential hypoglycaemic and antioxidant properties of aqueous broccoli extracts (BEs) in diabetic rats...
December 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/29333039/pharmacognostic-assesment-of-the-endemic-and-vulnerable-medicinal-climber-cayratia-pedata-lam-gagnep-var-glabra-gamble-and-its-antibacterial-activity
#4
S Sharmila, K Kalaichelvi, S M Dhivya, P Premamalini, P Abirami, G Jayanthi
Objective: The objective of this study is to evaluate a meticulous pharmacognostic cram is to supplement constructive information with regard to its identification, characterization, and standardization of endemic and endangered medicinal climber Cayratia pedata var. glabra and also screening the antibacterial activity of this climber. Materials and Methods: The morphological characters of study plant, microscopic examination of leaf powder, anatomy of young stem, physicochemical analysis of plant powder, extractive values, phytochemical analysis, powder with different chemical reagents, fluorescence analysis of plant powder, and other World Health Organization (WHO) recommended for standardization were analyzed...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29320672/position-statement-a-clinical-approach-to-the-management-of-adult-non-neurogenic-overactive-bladder
#5
Eric Chung, Dominic Lee, Johan Gani, Michael Gillman, Christopher Maher, Janelle Brennan, Lydia Johns Putra, Laura Ahmad, Lewis Lw Chan
Overactive bladder (OAB) is a highly prevalent medical condition that has an adverse impact on various health-related quality-of-life domains, including a significant psychosocial and financial burden. This position statement, formulated by members of the Urological Society of Australia and New Zealand and the UroGynaecological Society of Australasia, summarises the current recommendations for clinical diagnosis and treatment strategies in patients with non-neurogenic OAB, and guides clinicians in the decision-making process for managing the condition using evidence-based medicine...
January 15, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29318836/-study-of-extracting-peucedanum-praeruptorum-planted-area-in-ningguo-of-anhui-province-based-on-multi-source-and-multi-phase-image
#6
Ting-Ting Shi, Xiao-Bo Zhang, Ke Zhang, Lan-Ping Guo, Lu-Qi Huang
The herbs used as the material for traditional Chinese medicine are always planted in the mountainous area where the natural environment is suitable. As the mountain terrain is complex and the distribution of planting plots is scattered, the traditional survey method is difficult to obtain accurate planting area. It is of great significance to provide decision support for the conservation and utilization of traditional Chinese medicine resources by studying the method of extraction of Chinese herbal medicine planting area based on remote sensing and realizing the dynamic monitoring and reserve estimation of Chinese herbal medicines...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29318835/-study-on-extraction-method-of-panax-notoginseng-plots-in-wenshan-of-yunnan-province-based-on-decision-tree-model
#7
Ting-Ting Shi, Xiao-Bo Zhang, Lan-Ping Guo, Lu-Qi Huang
The herbs used as the material for traditional Chinese medicine are always planted in the mountainous area where the natural environment is suitable. As the mountain terrain is complex and the distribution of planting plots is scattered, the traditional survey method is difficult to obtain accurate planting area. It is of great significance to provide decision support for the conservation and utilization of traditional Chinese medicine resources by studying the method of extraction of Chinese herbal medicine planting area based on remote sensing and realizing the dynamic monitoring and reserve estimation of Chinese herbal medicines...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29318816/-status-of-traditional-chinese-medicine-materials-seed-and-seedling-breeding-bases
#8
Ying Li, Lu-Qi Huang, Xiao-Bo Zhang, Hui Wang, Meng Cheng, Tian Zhang, Guang Yang
Seeds and seedlings are the material basis of traditional Chinese medicine materials production, and the construction of traditional Chinese medicine materials seed and seedling breeding bases is beneficial to the production of high-quality traditional Chinese medicine materials. The construction of traditional Chinese medicine materials seed and seedling breeding bases is one of the major topics of Chinese medica resources census pilot. Targets, tasks of traditional Chinese medicine materials seed and seedling breeding bases based on Chinese medica resources census pilot were expounded...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29317334/systematic-identification-of-rabbit-lncrnas-reveals-functional-roles-in-atherosclerosis
#9
Jia Li, Qianlan Yao, Fangyoumin Feng, Sheng He, Ping Lin, Liguang Yang, Chuhua Yang, Hong Li, Yixue Li
Long noncoding RNAs (lncRNAs) have been gradually emerging as important regulators in various biological processes and diseases, while the contributions of lncRNAs to atherosclerosis remain largely unknown. Our previous work has discovered atherosclerosis associated protein-coding genes by transcriptome sequencing of rabbit models. Here we investigated the roles of lncRNAs in atherosclerosis. We defined a stringent set of 3736 multi-exonic lncRNA transcripts in rabbits. All lncRNAs are firstly reported and 609 (16...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29313948/human-dendritic-cell-subsets-an-update
#10
REVIEW
Matthew Collin, Venetia Bigley
Dendritic cells (DC) are a class of bone marrow derived cells arising from lympho-myeloid haematopoiesis that form an essential interface between the innate sensing of pathogens and the activation of adaptive immunity. This task requires a wide range of mechanisms and responses, which are divided between three major DC subsets: plasmacytoid DC (pDC), myeloid/conventional DC1 (cDC1) and myeloid/conventional DC2 (cDC2). Each DC subset develops under the control of a specific repertoire of transcription factors involving differential levels of IRF8 and IRF4 in collaboration with PU...
January 3, 2018: Immunology
https://www.readbyqxmd.com/read/29305696/14-3-3-proteins-are-involved-in-growth-hyphal-branching-ganoderic-acid-biosynthesis-and-response-to-abiotic-stress-in-ganoderma-lucidum
#11
Tian-Jun Zhang, Liang Shi, Dong-Dong Chen, Rui Liu, Deng-Ke Shi, Chen-Gao Wu, Ze-Hua Sun, Ang Ren, Ming-Wen Zhao
Ganoderma lucidum, which contains many pharmacologically active compounds, is regarded as a traditional medicinal fungus. Nevertheless, the scarcity of basic research limits the commercial value and utilization of G. lucidum. As a class of highly conserved, phosphopeptide-binding proteins present in all eukaryotes, 14-3-3 proteins play vital roles in controlling multiple physiological processes, including signal transduction, primary metabolism, and stress responses. However, knowledge of the roles of 14-3-3 proteins in Basidiomycetes is sparse...
January 5, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29302735/a-new-human-derived-acellular-dermal-matrix-for-breast-reconstruction-available-for-the-european-market-preliminary-results
#12
Secondo Folli, Annalisa Curcio, Davide Melandri, Elena Bondioli, Nicola Rocco, Giuseppe Catanuto, Fabio Falcini, Valeria Purpura, Matteo Mingozzi, Federico Buggi, Francesco Marongiu
INTRODUCTION: The introduction of acellular dermal matrices (ADMs) contributed to the growing diffusion of direct-to-implant breast reconstruction (DTI-BR) following mastectomy for breast cancer. According to specific legislations, European specialists could not benefit from the use of human-derived ADMs, even though most evidence in the literature are available for this kind of device, showed optimal outcomes in breast reconstruction. The Skin Bank of the Bufalini Hospital (Cesena, Italy) obtained in 2009 the approval for the production and distribution of a new human cadaver-donor-derived ADM (named with the Italian acronym, MODA, for matrice omologa dermica acellulata) from the Italian National Transplant Center and National Health Institute...
January 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29300381/a-homozygous-founder-missense-variant-in-arylsulfatase-g-abolishes-its-enzymatic-activity-causing-atypical-usher-syndrome-in-humans
#13
Samer Khateb, Björn Kowalewski, Nicola Bedoni, Markus Damme, Netta Pollack, Ann Saada, Alexey Obolensky, Tamar Ben-Yosef, Menachem Gross, Thomas Dierks, Eyal Banin, Carlo Rivolta, Dror Sharon
PurposeWe aimed to identify the cause of disease in patients suffering from a distinctive, atypical form of Usher syndrome.MethodsWhole-exome and genome sequencing were performed in five patients from three families of Yemenite Jewish origin, suffering from distinctive retinal degeneration phenotype and sensorineural hearing loss. Functional analysis of the wild-type and mutant proteins was performed in human fibrosarcoma cells.ResultsWe identified a homozygous founder missense variant, c.133G>T (p.D45Y) in arylsulfatase G (ARSG)...
January 4, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29299845/host-specificity-of-symbiotic-mycorrhizal-fungi-for-enhancing-seed-germination-protocorm-formation-and-seedling-development-of-over-collected-medicinal-orchid-dendrobium-devonianum
#14
Hui Huang, Xiao-Meng Zi, Hua Lin, Jiang-Yun Gao
All orchids maintain an obligate relationship with mycorrhizal symbionts during seed germination. In most cases, germination-enhancing fungi have been isolated from roots of mature plants for conservation and cultivation purposes. To understand the germination biology of Dendrobium devonianum, an over-collected medicinal orchid, the seeds of D. devonianum were inoculated with a fungal strain (FDd1) isolated from naturally occurring protocorms of D. devonianum and two other germination-enhancing fungal strains (FDaI7 and FCb4) from D...
January 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29297826/hematology-serum-biochemistry-and-urinalysis-values-in-the-adult-giant-panda-ailuropoda-melanoleuca
#15
Caitlin Burrell, Hemin Zhang, Desheng Li, Chengdong Wang, Caiwu Li, Copper Aitken-Palmer
The giant panda ( Ailuropoda melanoleuca) is a high-profile threatened species with individuals in captivity worldwide. As a result of advances in captive animal management and veterinary medicine, the ex situ giant panda population is aging, and improved understanding of age-related changes is necessary. Urine and blood samples were collected in April and July 2015 and analyzed for complete blood count, serum biochemistry, and biochemical and microscopic urine analysis for all individuals sampled ( n = 7, 7-16 yr of age) from giant panda housed at the China Research and Conservation Centre for the Giant Panda in Bifengxia, Sichuan Province, China...
December 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/29279721/recent-surgical-options-for-vestibular-vertigo
#16
REVIEW
Stefan Volkenstein, Stefan Dazert
Vertigo is not a well-defined disease but a symptom that can occur in heterogeneous entities diagnosed and treated mainly by otolaryngologists, neurologists, internal medicine, and primary care physicians. Most vertigo syndromes have a good prognosis and management is predominantly conservative, whereas the need for surgical therapy is rare, but for a subset of patients often the only remaining option. In this paper, we describe and discuss different surgical therapy options for hydropic inner ear diseases, Menière's disease, dehiscence syndromes, perilymph fistulas, and benign paroxysmal positional vertigo...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29278928/exploring-plant-tissue-culture-in-withania-somnifera-l-dunal-in-vitro-propagation-and-secondary-metabolite-production
#17
Shasmita, Manoj K Rai, Soumendra K Naik
Withania somnifera (L.) Dunal (family: Solanaceae), commonly known as "Indian Ginseng", is a medicinally and industrially important plant of the Indian subcontinent and other warmer parts of the world. The plant has multi-use medicinal potential and has been listed among 36 important cultivated medicinal plants of India that are in high demand for trade due to its pharmaceutical uses. The medicinal importance of this plant is mainly due to the presence of different types of steroidal lactones- withanolides in the roots and leaves...
December 26, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/29275226/reverse-engineering-organogenesis-through-feedback-loops-between-model-systems
#18
REVIEW
Cody Narciso, Jeremiah Zartman
Biological complexity and ethical limitations necessitate models of human development. Traditionally, genetic model systems have provided inexpensive routes to define mechanisms governing organ development. Recent progress has led to 3D human organoid models of development and disease. However, robust methods to control the size and morphology of organoids for high throughput studies need to be developed. Additionally, insights from multiple developmental contexts are required to reveal conserved genes and processes regulating organ growth and development...
December 21, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29274116/risk-of-hla-homozygous-cord-blood-transplantation-implications-for-induced-pluripotent-stem-cell-banking-and-transplantation
#19
Yasuo Morishima, Fumihiro Azuma, Koichi Kashiwase, Kayoko Matsumoto, Takeshi Orihara, Hiromasa Yabe, Shunichi Kato, Koji Kato, Shunro Kai, Tetsuo Mori, Kazunori Nakajima, Satoko Morishima, Masahiro Satake, Minoko Takanashi, Toshio Yabe
Clinical application of induced pluripotent stem cells (iPS) in autologous settings has just begun. To overcome the high time and cost barriers in the individual production of autologous iPS, the use of allogeneic iPS with a homozygous human leukocyte antigen (HLA) haplotype (HLA-homo HP) has been proposed. Cord blood transplantation (CBT) is a suitable model for evaluating the allogeneic immunogenicity of iPS transplantation from HLA-homo donors. We analyzed 1,374 Japanese single cord blood transplant pairs who were retrospectively typed as HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1...
December 23, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29261182/biallelic-and-monoallelic-esr2-variants-associated-with-46-xy-disorders-of-sex-development
#20
Dorien Baetens, Tülay Güran, Berenice B Mendonca, Nathalia L Gomes, Lode De Cauwer, Frank Peelman, Hannah Verdin, Marnik Vuylsteke, Malaïka Van der Linden, Hans Stoop, Leendert H Looijenga, Karolien De Bosscher, Martine Cools, Elfride De Baere
PurposeDisorders or differences of sex development (DSDs) are rare congenital conditions characterized by atypical sex development. Despite advances in genomic technologies, the molecular cause remains unknown in 50% of cases.MethodsHomozygosity mapping and whole-exome sequencing revealed an ESR2 variant in an individual with syndromic 46,XY DSD. Additional cases with 46,XY DSD underwent whole-exome sequencing and targeted next-generation sequencing of ESR2. Functional characterization of the identified variants included luciferase assays and protein structure analysis...
October 26, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
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