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https://www.readbyqxmd.com/read/27914758/fluid-therapy-in-lung-disease
#1
REVIEW
Elizabeth Rozanski, Alex Lynch
Fluid therapy is the cornerstone of supportive care in veterinary medicine. In dogs and cats with preexisting confirmed or suspected pulmonary disease, concerns may exist that the fluid therapy may impair gas exchange, either through increases in hydrostatic pressures or extravasation. Colloidal therapy is more likely to magnify lung injury compared with isotonic crystalloids. Radiographic evidence of fluid overload is a late-stage finding, whereas point-of-care ultrasound may provide earlier information that can also be assessed periodically at the patient side...
December 1, 2016: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/27908650/musculoskeletal-conditions-in-a-pediatric-population-with-ehlers-danlos-syndrome
#2
Courtney M Stern, Michael J Pepin, Joan M Stoler, Dennis E Kramer, Samantha A Spencer, Cynthia J Stein
OBJECTIVE: To describe musculoskeletal conditions in children with Ehlers-Danlos syndrome (EDS). STUDY DESIGN: A retrospective medical record review was performed, which evaluated 205 patients with EDS (ages 6-19 years) seen in sports medicine or orthopedic clinic at a large pediatric hospital over a 5-year period. RESULTS: Female (n = 147) and male (n = 57) patients were identified (mean age 12.7 years). The most common EDS subtype (55...
November 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27899896/respiratory-function-in-voluntary-participating-patagonia-sea-lions-otaria-flavescens-in-sternal-recumbency
#3
Andreas Fahlman, Johnny Madigan
We measured esophageal pressures (n = 4), respiratory flow rates (n = 5), and expired O2 and CO2 (n = 4) in five adult Patagonia sea lions (Otaria flavescens, body mass range 94.3-286.0 kg) during voluntary breaths while laying down out of water. The data were used to estimate the dynamic specific lung compliance (sCL), the O2 consumption rate ([Formula: see text]O2) and CO2 production rates ([Formula: see text]CO2) during rest. Our results indicate that the resting tidal volume in Patagonia sea lions is approximately 47-73% of the estimated total lung capacity...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27898817/genome-wide-identification-of-the-ap2-erf-gene-family-involved-in-active-constituent-biosynthesis-in
#4
A J Ji, H M Luo, Z C Xu, X Zhang, Y J Zhu, B S Liao, H Yao, J Y Song, S L Chen
Tanshinones and phenolic acids are the major bioactive constituents in the traditional medicinal crop ; however, transcription factors (TFs) are seldom investigated with regard to their regulation of the biosynthesis of these compounds. Here a complete overview of the APETALA2/ethylene-responsive factor (AP2/ERF) transcription factor family in is provided, including phylogeny, gene structure, conserved motifs, and gene expression profiles of different organs (root, stem, leaf, flower) and root tissues (periderm, phloem, xylem)...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27894033/the-age-related-recurrence-of-endometrioma-after-conservative-surgery
#5
Jong-Wook Seo, Dong-Yun Lee, Byung-Koo Yoon, DooSeok Choi
OBJECTIVE: As endometrioma frequently recurs after conservative surgery, long-term postoperative medical treatment for the prevention of recurrence is necessary. However, it has not been elucidated whether long-term postoperative medical treatment is crucial to all patients until menopause. Thereupon, this study was conducted to evaluate the age-related recurrence patterns after conservative surgery for endometrioma. STUDY DESIGN: A retrospective cohort study was performed on a total of 420 reproductive-aged women who underwent conservative surgery for endometrioma between January 2000 and December 2010...
November 16, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27890782/bromodomain-histone-readers-and-cancer
#6
REVIEW
Abhinav K Jain, Michelle C Barton
Lysine acetylation of histone proteins is a fundamental post-translational modification that regulates chromatin structure and plays an important role in gene transcription. Aberrant levels of histone lysine acetylation are associated with the development of several diseases. Acetyl-lysine modifications create docking sites for bromodomains, which are structurally conserved modules present in transcription-associated proteins that are termed "reader" proteins. Bromodomain-containing reader proteins are part of multi-protein complexes that regulate transcription programs, often associated with profound phenotypic changes...
November 24, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27885899/regenerative-medicine-lessons-from-mother-nature
#7
Juan Diego Naranjo, Michelle E Scarritt, Luai Huleihel, Anjani Ravindra, Crisanto M Torres, Stephen F Badylak
Regenerative medicine strategies for the restoration of functional tissue have evolved from the concept of ex vivo creation of engineered tissue toward the broader concept of in vivo induction of functional tissue reconstruction. Multidisciplinary approaches are being investigated to achieve this goal using evolutionarily conserved principles of stem cell biology, developmental biology and immunology, current methods of engineering and medicine. This evolution from ex vivo tissue engineering to the manipulation of fundamental in vivo tenets of development and regeneration has the potential to capitalize upon the incredibly complex and only partially understood ability of cells to adapt, proliferate, self-organize and differentiate into functional tissue...
December 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27885707/spatial-resolution-and-velocity-field-improvement-of-4d-flow-mri
#8
Fraser M Callaghan, Stuart M Grieve
PURPOSE: 4D-flow MRI obtains a time-dependent 3D velocity field; however, its use for the calculation of higher-order parameters is limited by noise. We present an algorithm for denoising 4D-flow data. THEORY AND METHODS: By integrating a velocity field and eliminating streamlines in noisy flow, depicted by high curvature, a denoised dataset may be extracted. This method, defined as the velocity field improvement (VFIT) algorithm, was validated in an analytical dataset and using in vivo data in comparison with a computation fluid dynamics (CFD) simulation...
November 24, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27878448/a-review-of-ecosystem-service-benefits-from-wild-bees-across-social-contexts
#9
REVIEW
Denise Margaret S Matias, Julia Leventon, Anna-Lena Rau, Christian Borgemeister, Henrik von Wehrden
In order to understand the role of wild bees in both social and ecological systems, we conducted a quantitative and qualitative review of publications dealing with wild bees and the benefits they provide in social contexts. We classified publications according to several attributes such as services and benefits derived from wild bees, types of bee-human interactions, recipients of direct benefits, social contexts where wild bees are found, and sources of changes to the bee-human system. We found that most of the services and benefits from wild bees are related to food, medicine, and pollination...
November 22, 2016: Ambio
https://www.readbyqxmd.com/read/27875310/extending-halogen-based-medicinal-chemistry-to-proteins-iodo-insulin-as-a-case-study
#10
Krystel El Hage, Vijay Pandyarajan, Nelson B Phillips, Brian J Smith, John G Menting, Jonathan Whittaker, Michael C Lawrence, Markus Meuwly, Michael A Weiss
Insulin, a protein critical for metabolic homeostasis, provides a classical model for protein design with application to human health. Recent efforts to improve its pharmaceutical formulation demonstrated that iodination of a conserved tyrosine (Tyr(B26)) enhances key properties of a rapid-acting clinical analog. Moreover, the broad utility of halogens in medicinal chemistry has motivated use of hybrid quantum- and molecular-mechanical methods to study proteins. Here, we (i) undertook quantitative atomic-level simulations of 3-I-Tyr(B26)-insulin to predict its structural features and (ii) tested these predictions by X-ray crystallography...
November 14, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27871217/identification-of-marine-traditional-chinese-medicine-dried-seahorses-in-the-traditional-chinese-medicine-market-using-dna-barcoding
#11
Feixia Hou, Longlian Wen, Cheng Peng, Jinlin Guo
Seahorse documented in Chinese pharmacopeia possess important medicinal efficacy and are used as an ingredient in traditional Chinese medicines. The growing international trade threatens the species. DNA barcoding holds a great application potentiality in wildlife conservation and might prevent the illegal trade of threatened species. The COI gene was used to identify seahorse, and nine Hippocampus species were found in the three large traditional Chinese medicines markets of China. All inter-specific genetic variations were larger than 2%...
November 22, 2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/27869309/roles-of-notch-signaling-in-adipocyte-progenitor-cells-and-mature-adipocytes
#12
REVIEW
Tizhong Shan, Jiaqi Liu, Weiche Wu, Ziye Xu, Yizhen Wang
Adipose tissues, composed with mature adipocytes and preadipocytic stromal/stem cells, play crucial roles in whole body energy metabolism and regenerative medicine. Mature adipocytes are derived and differentiated from mesenchymal stem cells (MSCs) or preadipocytes. This differentiation process, also called adipogenesis, is regulated by several signaling pathways and transcription factors. Notch1 signaling is a highly conserved pathway that is indispensable for stem cell hemostasis and tissue development. In adipocyte progenitor cells, Notch1 signaling regulates the adipogenesis process including proliferation and differentiation of the adipocyte progenitor cells in vitro...
November 21, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27867826/development-of-intron-polymorphism-markers-in-major-latex-like-protein-gene-for-locality-level-and-cultivar-identification-of-salvia-miltiorrhiza
#13
Hongtao Wang, Na Hao, Lei Chen, Guisheng Li
BACKGROUND: Salvia miltiorrhiza (Danshen) is one of the most widely used medicinal herbs in traditional Chinese medicine. Locality-level and cultivar identification is of great importance not only for protecting highest therapeutic effectiveness of Daodi Danshen, but also for the genetic conservation and utilization of existing S. miltiorrhiza populations. RESULTS: Intron polymorphisms including SNPs (single nucleotide polymorphisms) and indels were exploited in major latex-like protein (MLP) gene...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27867322/a-certified-health-physicist-s-reflections-on-a-40-year-career-in-radiation-protection
#14
Mark L Miller
This is a reflection from a certified health physicist regarding his becoming aware, during his 40-year career, that the linear no-threshold (LNT) model and the associated As Low As Reasonably Achievable concept have no scientific basis and make no positive contribution to radiation safety. They should be replaced by an alternative, scientifically based model that includes a threshold, below which there is no harm, and recognition of hormesis and the adaptive response, which reflect the benefits of low-dose and low-dose-rate radiation exposure...
October 2016: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/27862181/identification-of-biomarker-by-treatment-interactions-in-randomized-clinical-trials-with-survival-outcomes-and-high-dimensional-spaces
#15
Nils Ternès, Federico Rotolo, Georg Heinze, Stefan Michiels
Stratified medicine seeks to identify biomarkers or parsimonious gene signatures distinguishing patients that will benefit most from a targeted treatment. We evaluated 12 approaches in high-dimensional Cox models in randomized clinical trials: penalization of the biomarker main effects and biomarker-by-treatment interactions (full-lasso, three kinds of adaptive lasso, ridge+lasso and group-lasso); dimensionality reduction of the main effect matrix via linear combinations (PCA+lasso (where PCA is principal components analysis) or PLS+lasso (where PLS is partial least squares)); penalization of modified covariates or of the arm-specific biomarker effects (two-I model); gradient boosting; and univariate approach with control of multiple testing...
November 15, 2016: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/27861483/-on-roman-philonium
#16
Guillermo Delgado-García, Carolina Rodríguez-Návarez, Bruno Estañol
The roman philonium (Philonium Romanum) is an example of pharmacological poetry. This opiate was conceived by Philo of Tarsus, who was active during the first century of the Common Era. His antidote was written in elegiac couplets. The conservation of these couplets is owed to Galen, who reproduced them in the ninth book of On the Composition of Medicines according to the Places. Most of this Galenic treatise has not been translated into Spanish. For the first time, we offer this prescription in our language from a French version of the fin de siècle...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27860286/trends-in-off-label-prescribing-of-sedatives-hypnotics-and-antidepressants-among-children-and-adolescents-a-danish-nationwide-register-based-study
#17
Eva Skovslund Nielsen, Lotte Rasmussen, Maja Hellfritzsch Poulsen, Per Hove Thomsen, Mette Nørgaard, Torben Laursen
In recent years, psychotropic drug use among children and adolescents in Europe and USA has increased. However, the majority of psychotropic drugs are not formally approved for use in children and adolescents, and consequently, use is often off-label. The objectives were to describe time trends in off-label prescribing rates and the most commonly used types of psychotropic drugs by age and gender in Danish children and adolescents. Using the Register of Medicinal Product Statistics, we identified all prescriptions for sedatives, hypnotics and antidepressants filled for children and adolescents in 2006-2012...
November 17, 2016: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27855426/idiopathic-scoliosis-from-psychopathological-and-mind-body-medicine-perspectives
#18
Goran Talić, Ljerka Ostojić, Snježana Novaković Bursać, Tatjana Nožica-Radulović, Đurđica Stevanović-Papić
Idiopathic scoliosis, defined as a three-dimensional spine and trunk deformity, which appears in otherwise healthy subjects, exhibits complex relations with various forms of personal well-being and psychopathology. Most research studies have documented a higher proportion of psychological disturbances (e.g., self-criticism, negative body image, low self-esteem) and mental disorders (e.g., anxiety and depressive disorders, personality disorders) among idiopathc scoliosis patients compared to healthy controls...
December 2016: Psychiatria Danubina
https://www.readbyqxmd.com/read/27854037/antifungal-lipopeptides-produced-by-bacillus-sp-fjat-14262-isolated-from-rhizosphere-soil-of-the-medicinal-plant-anoectochilus-roxburghii
#19
Qianqian Chen, Bo Liu, Jieping Wang, Jianmei Che, Guohong Liu, Xiong Guan
This study aimed to develop biocontrol Bacillus and explore bacterial biocontrol substances. According to the blood agar test, strain FJAT-14262 was screened as a biosurfactant-producer. The biosurfactant-producing ability of FJAT-14262 was further confirmed by the oil spreading tests because of its amphipathic character. Furthermore, its fermentation supernatant could decrease the surface tension from 74.1 to 32.7 mN m(-1). Fourier transform infrared spectroscopy (FT-IR) analysis indicated that the biosurfactant produced by the strain FJAT-14262 was a kind of lipopeptides...
November 16, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27853564/bushmeat-hunting-and-extinction-risk-to-the-world-s-mammals
#20
William J Ripple, Katharine Abernethy, Matthew G Betts, Guillaume Chapron, Rodolfo Dirzo, Mauro Galetti, Taal Levi, Peter A Lindsey, David W Macdonald, Brian Machovina, Thomas M Newsome, Carlos A Peres, Arian D Wallach, Christopher Wolf, Hillary Young
Terrestrial mammals are experiencing a massive collapse in their population sizes and geographical ranges around the world, but many of the drivers, patterns and consequences of this decline remain poorly understood. Here we provide an analysis showing that bushmeat hunting for mostly food and medicinal products is driving a global crisis whereby 301 terrestrial mammal species are threatened with extinction. Nearly all of these threatened species occur in developing countries where major coexisting threats include deforestation, agricultural expansion, human encroachment and competition with livestock...
October 2016: Royal Society Open Science
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