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https://www.readbyqxmd.com/read/28812535/associating-mutations-causing-cystinuria-with-disease-severity-with-the-aim-of-providing-precision-medicine
#1
Henry J Martell, Kathie A Wong, Juan F Martin, Ziyan Kassam, Kay Thomas, Mark N Wass
BACKGROUND: Cystinuria is an inherited disease that results in the formation of cystine stones in the kidney, which can have serious health complications. Two genes (SLC7A9 and SLC3A1) that form an amino acid transporter are known to be responsible for the disease. Variants that cause the disease disrupt amino acid transport across the cell membrane, leading to the build-up of relatively insoluble cystine, resulting in formation of stones. Assessing the effects of each mutation is critical in order to provide tailored treatment options for patients...
August 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28812199/complete-genome-sequence-of-a-putative-new-caulimovirus-which-exists-as-endogenous-pararetroviral-sequences-in-angelica-dahurica
#2
Seungmo Lim, Dasom Baek, Davaajargal Igori, Jae Sun Moon
A virus isolate designated Angelica bushy stunt virus (AnBSV), provisionally representing a new species in the genus Caulimovirus, was discovered in the medicinal plant Angelica dahurica. The complete 8,300-nt genomic DNA of AnBSV had seven putative open reading frames containing conserved domains/motifs, which are typical features of caulimoviruses, and showed the greatest nucleotide sequence identity (74% identity and 27% query coverage) to a lamium leaf distortion virus isolate. Interestingly, the new caulimovirus exists as endogenous pararetroviral sequences in the host plant and is considered to have multiple defective plant genome-integrated copies that may lead to the generation of subgenomic DNA species...
August 10, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28803466/deciphering-the-fluorine-code-the-many-hats-fluorine-wears-in-a-protein-environment
#3
Allison Ann Berger, Jan-Stefan Völler, Nediljko Budisa, Beate Koksch
Deciphering the fluorine code is how we describe not only the focus of this Account, but also the systematic approach to studying the impact of fluorine's incorporation on the properties of peptides and proteins used by our groups and others. The introduction of fluorine has been shown to impart favorable, but seldom predictable, properties to peptides and proteins, but up until about two decades ago the outcomes of fluorine modification of peptides and proteins were largely left to chance. Driven by the motivation to extend the application of the unique properties of the element fluorine from medicinal and agro chemistry to peptide and protein engineering we have established extensive research programs that enable the systematic investigation of effects that accompany the introduction of fluorine into this class of biopolymers...
August 12, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28799492/potentials-and-limits-of-physiotherapy-in-osteoarthritis
#4
Katrin Richter, Ulf Müller-Ladner, Gabnel Dischereit, Uwe Lange
In view of the already existing and the expected growing costs due to the pathological osteoarthritic joint alterations and the related consequences, preventive and conservative strategies which can avoid or delay osteoarthritic joint alterations are welcomed from a socio-economical perspective. Here, it should be mentioned that corresponding primary prevention measures should take place early by already educating children about a healthy diet and motivating them to regular physical exercise. In overt or symptomatic osteoarthritis a good joint function and reduction of disease-related pain as well as a delay in the progression of osteoarthritis should be the primary goals of non-surgical therapeutic approaches...
August 10, 2017: Current Rheumatology Reviews
https://www.readbyqxmd.com/read/28794185/id-genes-are-essential-for-early-heart-formation
#5
Thomas J Cunningham, Michael S Yu, Wesley L McKeithan, Sean Spiering, Florent Carrette, Chun-Teng Huang, Paul J Bushway, Matthew Tierney, Sonia Albini, Mauro Giacca, Miguel Mano, Pier Lorenzo Puri, Alessandra Sacco, Pilar Ruiz-Lozano, Jean-Francois Riou, Muriel Umbhauer, Gregg Duester, Mark Mercola, Alexandre R Colas
Deciphering the fundamental mechanisms controlling cardiac specification is critical for our understanding of how heart formation is initiated during embryonic development and for applying stem cell biology to regenerative medicine and disease modeling. Using systematic and unbiased functional screening approaches, we discovered that the Id family of helix-loop-helix proteins is both necessary and sufficient to direct cardiac mesoderm formation in frog embryos and human embryonic stem cells. Mechanistically, Id proteins specify cardiac cell fate by repressing two inhibitors of cardiogenic mesoderm formation-Tcf3 and Foxa2-and activating inducers Evx1, Grrp1, and Mesp1...
August 9, 2017: Genes & Development
https://www.readbyqxmd.com/read/28791203/development-and-characterization-of-microsatellite-primers-for-zanthoxylum-schinifolium-rutaceae
#6
Young Mi Kim, Aruna Jo, Ji Hee Jeong, Yong Rak Kwon, Ho Bang Kim
PREMISE OF THE STUDY: Polymorphic microsatellite markers of Zanthoxylum schinifolium (Rutaceae), a promising medicinal plant with effective antibacterial, anticancer, and anti-inflammatory compounds, were developed and evaluated for further genetic studies based on genetic variation among individuals or populations. METHODS AND RESULTS: Following the selective hybridization method, microsatellite-enrichment libraries were constructed. Using these libraries, we obtained 15 polymorphic and three monomorphic microsatellite markers for Z...
July 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28777213/glenohumeral-instability-related-to-special-conditions-slap-tears-pan-labral-tears-and-multidirectional-instability
#7
Gregory S Van Blarcum, Steven J Svoboda
Glenohumeral instability is one of the more common conditions seen by sports medicine physicians, especially in young, active athletes. The associated anatomy of the glenohumeral joint (the shallow nature of the glenoid and the increased motion it allows) make the shoulder more prone to instability events as compared with other joints. Although traumatic dislocations or instability events associated with acute labral tears (ie, Bankart lesions) are well described in the literature, there exists other special shoulder conditions that are also associated with shoulder instability: superior labrum anterior/posterior (SLAP) tears, pan-labral tears, and multidirectional instability...
September 2017: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/28759964/extracorporeal-perfusion-reduced-to-a-one-way-infusion
#8
Christian D Taeger, Oliver Friedrich, Raymund E Horch, Caroline Drechsler, Annika Weigand, Fabio Hopf, Carol I Geppert, Frank Münch, Torsten Birkholz, Carina Wenzel, Sebastian Geis, Lukas Prantl, Rainer Buchholz, Konstantin Präbst
BACKGROUND: Extracorporeal perfusion (EP) is moving into focus of research in reconstructive and transplantation medicine for the preservation of amputates and free tissue transplants. The idea behind EP is the reduction of ischemia-related cell damage between separation from blood circulation and reanastomosis of the transplant. Most experimental approaches are based on a complex system that moves the perfusate in a circular course. OBJECTIVE AND METHODS: In this study, we aimed to evaluate if a simple perfusion by an infusion bag filled with an electrolyte solution can provide acceptable results in terms of flow stability, oxygen supply and viability conservation for EP of a muscle transplant...
July 25, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28757480/research-progresses-on-the-molecular-structure-of-the-hippo-signaling-pathway-components
#9
Hu Liqiao, Zhou Zhaocai, Tian Wei
The Hippo signaling pathway has been identified to be involved in development and tissue homeostasis during the past decade, and is evolutionarily conserved from Drosophila to mammals. It transduces the signal through a series of protein-protein interaction and kinase cascades, to control the cell number and organ size by inhibiting cell proliferation and promoting apoptosis. Dysregulation of the Hippo signaling pathway is associated with tumorigenesis and cancers, so it is a crucial target for cancer therapy and regeneration medicine...
July 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28756048/frailty-assessments-in-surgical-practice-what-is-frailty-and-how-can-it-be-used-in-prosthetic-health
#10
REVIEW
Matthew S Brennan, Ryan M Barlotta, Jay Simhan
INTRODUCTION: Surgical frailty is a previously unrecognized clinical entity that objectifies a multiorgan decrease in physiologic reserve in those undergoing surgery. Although penile implantation has been demonstrated to be an effective means of restoring erectile function in patients whose previous conservative measures have failed, there are limited data regarding the assessment of frailty in patients undergoing penile implantation. AIM: To review the various objective methods used to describe surgical frailty in medical and surgical disciplines, report on methodologies of frailty assessment, and discuss the relevance of surgical frailty in the preoperative evaluation of patients undergoing implantation of an inflatable penile prosthesis...
July 26, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28755969/plant-based-remedies-for-wolf-bites-and-rituals-against-wolves-in-the-iberian-peninsula-therapeutic-opportunities-and-cultural-values-for-the-conservation-of-biocultural-diversity
#11
REVIEW
José A González, Ana Maria Carvalho, José Ramón Vallejo, Francisco Amich
ETHNOPHARMACOLOGICAL RELEVANCE: Combined approaches to local knowledge and folk plant use improve awareness and promote effective strategies for the conservation of significant biocultural patrimony. Moreover, the information reported might be the basis for further appropriate phytochemical and pharmacological research. Therefore we provide an insight into traditional herbal remedies and practices for healing bite injuries in humans and domestic animals caused by the Iberian wolf. Wolf bites are associated with inflammatory processes and rabies is a potential complication AIMS: This paper describes and summarises the medicinal-veterinary empirical and ritual uses of the Iberian flora for wolf injuries and reviews the ethnopharmacological data of specific plants that are already published...
July 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28750804/ligand-assisted-protein-structure-laps-an-experimental-paradigm-for-characterizing-cannabinoid-receptor-ligand-binding-domains
#12
David R Janero, Anisha Korde, Alexandros Makriyannis
Detailed characterization of the ligand-binding motifs and structure-function correlates of the principal GPCRs of the endocannabinoid-signaling system, the cannabinoid 1 (CB1R) and cannabinoid 2 (CB2R) receptors, is essential to inform the rational design of drugs that modulate CB1R- and CB2R-dependent biosignaling for therapeutic gain. We discuss herein an experimental paradigm termed "ligand-assisted protein structure" (LAPS) that affords a means of characterizing, at the amino acid level, CB1R and CB2R structural features key to ligand engagement and receptor-dependent information transmission...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28745662/-atropine-use-for-progressive-myopia-in-children-and-adolescents
#13
T Yu Verzhanskaya
The worldwide prevalence of myopia varies within the range of 20-50% among the adult population of Europe and the United States reaching 60-90% in Asian countries. Reduction of pediatric myopia rates is an important task of medicine. From many reported conservative methods for stabilization of myopia, those that involve pharmaceutical measures are worth paying attention to. This review covers publications dated 1964 or later that contain the results of atropine use at different concentrations in children and adolescents with a minimum follow-up period of 5 years...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28743930/full-length-cloning-sequence-analysis-and-expression-detection-of-the-%C3%AE-tubulin-gene-from-the-chinese-gall-aphid-schlechtendalia-chinensis
#14
Ping Liu, Zi-Xiang Yang, Xiao-Ming Chen, Hang Chen
Some insect galls are formed on sumac plants by certain aphid species and have been used for medicinal and chemical purposes as they are rich in tannins. The most prominent species among gall aphids in China is Schlechtendalia chinensis, which formed horn-shaped galls on the winged rachis of Rhus chinensis. S. chinensis has a complex life cycle, with a switch of hosts between R. chinensis and certain mosses, and a switch of sexual and asexual reproduction (cyclical parthenogenesis). We have cloned a full-length cDNA of the β-tubulin gene from S...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743274/risk-factors-and-a-prediction-model-for-lower-limb-lymphedema-following-lymphadenectomy-in-gynecologic-cancer-a-hospital-based-retrospective-cohort-study
#15
Kenji Kuroda, Yasuhiro Yamamoto, Manami Yanagisawa, Akira Kawata, Naoya Akiba, Kensuke Suzuki, Kazutoshi Naritaka
BACKGROUND: Lower limb lymphedema (LLL) is a chronic and incapacitating condition afflicting patients who undergo lymphadenectomy for gynecologic cancer. This study aimed to identify risk factors for LLL and to develop a prediction model for its occurrence. METHODS: Pelvic lymphadenectomy (PLA) with or without para-aortic lymphadenectomy (PALA) was performed on 366 patients with gynecologic malignancies at Yaizu City Hospital between April 2002 and July 2014; we retrospectively analyzed 264 eligible patients...
July 25, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28737941/unveiling-the-catalytic-role-of-b-block-histidine-in-the-n-s-acyl-shift-step-of-protein-splicing
#16
Jon I Mujika, Xabier Lopez
Protein splicing is a post-translational modification that involves the excision of a segment denoted as intein and the joining of its two flanking segments. The process is auto-catalytic, making inteins appealing for many applications in biotechnology, bioengineering, or medicine. The canonical mechanism of protein splicing is composed of four sequential steps, and is initialized by an N-S or N-O acyl shift to form a linear ester. It is well established that a histidine, the most conserved amino acid in all inteins catalyzes this initial step, even though its role remains to be understood...
July 24, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28736756/advancing-the-science-of-myocardial-recovery-with-mechanical-circulatory-support-a-working-group-of-the-national-heart-lung-and-blood-institute
#17
Stavros G Drakos, Francis D Pagani, Martha S Lundberg, J Timothy Baldwin
The medical burden of heart failure (HF) has spurred interest in clinicians and scientists to develop therapies to restore the function of a failing heart. To advance this agenda, the National Heart Lung Blood Institute (NHLBI) convened a Working Group of experts on June 2-3, 2016 in Bethesda Maryland to develop recommendations for the NHLBI aimed at advancing the science of cardiac recovery in the setting of mechanical circulatory support (MCS). MSC devices effectively reduce volume and pressure overload that drives the cycle of progressive myocardial dysfunction, thereby triggering structural and functional reverse remodeling...
June 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28735232/immunoglobulin-g4-related-mastitis-a-case-report
#18
Ee Syn Tan, Brendon Friesen, Seow Foong Loh, Jane Fox
INTRODUCTION: IgG4-related mastitis (IgG4-RM) is exceedingly rare with only ten cases reported in the literature to date. Organs that are affected with IgG4-related disease (IgG4-RD) all share the same histopathological hallmarks consisting of dense lymphocytic infiltration, storiform fibrosis and obliterative phlebitis. PRESENTATION OF CASE: This case report highlights a case of IgG4-RM found incidentally in a 52-year-old woman during a routine breast screen and it explores the current literature about IgG4-RM and IgG4-RD...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28732541/endobronchial-embolization-for-life-threatening-hemoptysis-with-endobronchial-watanabe-spigot
#19
Sze Shyang Kho, Swee Kim Chan, Mei Ching Yong, Siew Teck Tie
BACKGROUND: Massive hemoptysis is a common encounter in respiratory medicine. Bronchoscopy plays an important role in localizing the origin of bleeding, as well as endoscopic treatment of centrally located lesions. Endobronchial embolization is a novel technique enabling the management of hemoptysis arising even from peripheral lesions, via occlusion of the culprit bronchus, thereby securing the airway. Endobronchial Watanabe Spigot had been advocate in the treatment of bronchopleural fistula and the use of this novel technique had since then been expanded into the management of massive hemoptysis...
July 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28729656/endolysosomal-targeting-of-a-clinical-chlorin-photosensitiser-for-light-triggered-delivery-of-nano-sized-medicines
#20
Elnaz Yaghini, Ruggero Dondi, Kunal M Tewari, Marilena Loizidou, Ian M Eggleston, Alexander J MacRobert
A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. Photochemical internalisation (PCI) is a technique for inducing cytosolic release of the entrapped agents that harnesses sub-lethal photodynamic therapy (PDT) using a photosensitiser that localises in endolysosomal membranes...
July 20, 2017: Scientific Reports
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