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https://www.readbyqxmd.com/read/29668141/-prevalence-and-risk-factors-associated-to-tuberculosis-and-non-tuberculous-mycobacterial-infections-in-hiv-positive-patients-in-bogot%C3%A3
#1
Magda Beltrán-León, Francy Pérez-Llanos, Liliana Sánchez, Carlos Parra-López, Myriam Navarrete, Ricardo Sánchez, Carlos Awad, Ana María Granada, Edgardo Quintero, Óscar Briceño, Óscar Cruz, Martha Isabel Murcia
INTRODUCTION: Tuberculosis is one of the most widely distributed infectious diseases worldwide. It is the most common cause of mortality among AIDS patients. In Colombia, 12,918 tuberculosis cases were notified, and 926 deaths were reported in 2015. OBJECTIVE: To determine the prevalence and risk factors associated to mycobacterial infections in HIVpositive patients in two public hospitals from Bogotá. MATERIALS AND METHODS: A prospective and descriptive study was carried out by an active search for tuberculosis cases and non-tuberculous mycobacterial infections in HIV-positive patients...
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29667882/new-doppler-imaging-technique-for-assessing-angiogenesis-in-breast-tumors-correlation-with-immunohistochemically-analyzed-microvessels-density
#2
Sewha Kim, Hye Jin Lee, Kyung Hee Ko, Ah Young Park, Jieun Koh, Hae Kyoung Jung
Background Microvessel density (MVD) is associated with grade and prognosis in breast tumors. However, conventional color Doppler flow (CDF) imaging has been limited to represent MVD of breast tumors. Purpose To evaluate whether a new Doppler imaging technique (AngioPLUS) can represent MVD of breast tumors. Material and Methods The institutional review board approved this retrospective study, and patients' informed consent was waived. CDF and AngioPLUS were available in pathologically confirmed 55 breast tumors of 53 women...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667636/-the-distribution-of-2-dimethylamino-ethyl-1-hydroxycyclopentyl-phenyl-acetate-in-the-organism-of-the-warm-blooded-animals-after-its-intra-gastric-administration
#3
V K Shormanov, M F Pravdyuk, V Yu Kuzovlev, N V Shabunina
The objective of the present study was to elucidate the distribution of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organism of the warm-blooded animals after its intra-gastric administration. The methods applied in the study included thin layer chromatography in silicagel, aci-nitroprosalt staining reaction, UV-spectrophotometry,, and GC-mass spectrometry. The identification and the quantitation of 2-(dimethylamino)ethyl-(1-hydroxycyclopentyl)(phenyl)acetate in the organs and blood of the warm-blooded animals were carried out within 20, 150, and 360 min after a single intra-gastric administration of 1300 ml of this poisonous substance...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29667556/ultrasound-promoted-green-synthesis-docking-study-of-indole-spliced-thiadiazole-%C3%AE-amino-phosphonates-as-anticancer-agents-and-anti-tyrosinase-agents
#4
Anna Pratima G Nikalje, Pramod Gawhane, Shailee Tiwari, Jaiprakash Sangshetti, Manoj Damale
In this work, a new series of diethyl ((1H-indole-3-yl)((5-phenyl-1,3,4-thiadiazole-2- yl)amino)methyl)phosphonate derivatives 6(a-j) were designed and synthesized in Ultrasound by green protocol using Kabachnik-Fields reaction. The structures of the synthesized compounds were confirmed by spectral analysis such as elemental analyses, IR, 1H NMR, 13C NMR, 31P NMR and mass spectra. The synthesized compounds 6(a-j) were appraised for their in vitro anticancer activity against human cancer cell lines such as SK-MEL-2 (melanoma), IMR-32 (Neuroblastoma), HT-29(Colon) and also on normal murine embryonic fibroblast NIH/3T3 by Sulforhodamine B (SRB) assay, using Adriamycin as a standard drug...
April 17, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29666448/regions-of-open-water-and-melting-sea-ice-drive-new-particle-formation-in-north-east-greenland
#5
M Dall Osto, C Geels, D C S Beddows, D Boertmann, R Lange, J K Nøjgaard, Roy M Harrison, R Simo, H Skov, A Massling
Atmospheric new particle formation (NPF) and growth significantly influences the indirect aerosol-cloud effect within the polar climate system. In this work, the aerosol population is categorised via cluster analysis of aerosol number size distributions (9-915 nm, 65 bins) taken at Villum Research Station, Station Nord (VRS) in North Greenland during a 7 year record (2010-2016). Data are clustered at daily averaged resolution; in total, we classified six categories, five of which clearly describe the ultrafine aerosol population, one of which is linked to nucleation events (up to 39% during summer)...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666274/vibrations-of-a-molecule-in-an-external-force-field
#6
Norio Okabayashi, Angelo Peronio, Magnus Paulsson, Toyoko Arai, Franz J Giessibl
The oscillation frequencies of a molecule on a surface are determined by the mass distribution in the molecule and the restoring forces that occur when the molecule bends. The restoring force originates from the atomic-scale interaction within the molecule and with the surface, which plays an essential role in the dynamics and reactivity of the molecule. In 1998, a combination of scanning tunneling microscopy with inelastic tunneling spectroscopy revealed the vibrational frequencies of single molecules adsorbed on a surface...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666235/mass-and-heat-transfer-between-evaporation-and-condensation-surfaces-atomistic-simulation-and-solution-of-boltzmann-kinetic-equation
#7
Vasily V Zhakhovsky, Alexei P Kryukov, Vladimir Yu Levashov, Irina N Shishkova, Sergey I Anisimov
Boundary conditions required for numerical solution of the Boltzmann kinetic equation (BKE) for mass/heat transfer between evaporation and condensation surfaces are analyzed by comparison of BKE results with molecular dynamics (MD) simulations. Lennard-Jones potential with parameters corresponding to solid argon is used to simulate evaporation from the hot side, nonequilibrium vapor flow with a Knudsen number of about 0.02, and condensation on the cold side of the condensed phase. The equilibrium density of vapor obtained in MD simulation of phase coexistence is used in BKE calculations for consistency of BKE results with MD data...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29665890/a-novel-technique-to-identify-the-nerve-of-origin-in-head-and-neck-schwannomas
#8
H H Ching, A G Spinner, N H Reeve, R C Wang
OBJECTIVE: Identifying the nerve of origin in head and neck schwannomas is a diagnostic challenge. Surgical management leads to a risk of permanent deficit. Accurate identification of the nerve would improve operative planning and patient counselling. METHODS: Three patients with head and neck schwannomas underwent a diagnostic procedure hypothesised to identify the nerve of origin. The masses were infiltrated with 1 per cent lidocaine solution, and the patients were observed for neurological deficits...
April 18, 2018: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29665834/inequalities-in-the-prevalence-of-diabetes-mellitus-and-its-risk-factors-in-sri-lanka-a-lower-middle-income-country
#9
Ambepitiyawaduge Pubudu De Silva, Sudirikku Hennadige Padmal De Silva, Rashan Haniffa, Isurujith Kongala Liyanage, Saroj Jayasinghe, Prasad Katulanda, Chandrika Neelakanthi Wijeratne, Sumedha Wijeratne, Lalini Chandika Rajapaksa
BACKGROUND: Explorations into quantifying the inequalities for diabetes mellitus (DM) and its risk factors are scarce in low and lower middle income countries (LICs/LMICs). The aims of this study were to assess the inequalities of DM and its risk factors in a suburban district of Sri Lanka. METHODS: A sample of 1300 participants, (aged 35-64 years) randomly selected using a stratified multi-stage cluster sampling method, were studied employing a cross sectional descriptive design...
April 17, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29665472/off-line-solid-phase-extraction-and-liquid-chromatography-tandem-mass-spectrometry-method-for-the-quantitation-of-brivaracetam-acid-metabolites-method-validation-and-application-to-in-vitro-metabolism-assays
#10
Emmanuel Bourgogne, Benoit Culot, Sylvie Dell'Aiera, Hugues Chanteux, Armel Stockis, Jean-Marie Nicolas
Brivaracetam (BRV) is a new high affinity synaptic vesicle protein 2A ligand recently approved for adults with partial-onset seizures. As a support to in vitro metabolism assays, a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method coupled to off-line solid phase extraction (SPE) was developed to quantify BRV acid metabolites, that is, BRV-AC (carboxylic derivative derived from BRV hydrolysis) and BRV-OHAC (corresponding to hydroxylated BRV-AC). The method was validated for various incubates (liver and kidney tissue homogenates and blood, all from humans) and applied to in vitro metabolism assays...
April 10, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29665456/the-contribution-of-obesity-to-carotid-atherosclerotic-plaque-burden-in-a-general-population-sample-in-norway-the-troms%C3%A3-study
#11
Yume Imahori, Ellisiv B Mathiesen, David A Leon, Laila A Hopstock, Alun D Hughes, Stein Harald Johnsen, Lone Jørgensen, Nina Emaus, Katy E Morgan
BACKGROUND AND AIMS: Few studies have investigated the association of different measures of adiposity with carotid plaque. We aimed to investigate and compare the associations of four measures of adiposity: body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) with the presence of carotid plaque and total plaque area (TPA) in the right carotid artery. METHODS: We included 4906 individuals aged 31-88 years who participated in a population-based study with ultrasonography of the right carotid artery...
April 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29664336/left-ventricular-myocardial-deformation-on-cine-mr-images-relationship-to-severity-of-disease-and-prognosis-in-amyloid-light-chain-amyloidosis
#12
Ke Wan, Jiayu Sun, Dan Yang, Hong Liu, Jie Wang, Wei Cheng, Qing Zhang, Zhi Zeng, Tianjing Zhang, Andreas Greiser, Marie-Pierre Jolly, Yuchi Han, Yucheng Chen
Purpose To measure left ventricular (LV) myocardial strain with cine magnetic resonance (MR) imaging and a deformable registration algorithm (DRA) and to assess the prognostic value of myocardial strain in patients with light-chain (AL) amyloidosis. Materials and Methods In this prospective study, 78 consecutive patients with AL amyloidosis who underwent contrast material-enhanced cardiac MR imaging were enrolled at West China Hospital. LV myocardial strains and late gadolinium enhancement (LGE) were evaluated...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29663868/imaging-mass-spectrometry-of-endogenous-polypeptides-and-secondary-metabolites-from-galls-induced-by-root-knot-nematodes-in-tomato-roots
#13
Eder Alves Barbosa, Mauro Ferreira Bonfim Junior, Carlos Bloch, Thales Lima Rocha, Gilbert Engler, Janice de Almeida Engler
Nematodes are devastating pests that infect most cultivated plant species and cause considerable agricultural losses worldwide. The understanding of metabolic adjustments induced during plant-nematode interaction is crucial to generate resistant plants or to select more efficient molecules to fight against this pest. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been used herein for in situ detection and mapping endogenous polypeptides and secondary metabolites from nematode-induced gall tissue...
April 17, 2018: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29663506/new-classification-of-geometric-ventricular-patterns-in-severe-aortic-stenosis-could-it-be-clinically-useful
#14
Concetta Di Nora, Eugenio Cervesato, Iulian Cosei, Andreea Ravasel, Bogdan A Popescu, Concetta Zito, Scipione Carerj, Francesco Antonini-Canterin, Andreea C Popescu
BACKGROUND: In severe aortic stenosis, different left ventricle (LV) remodeling patterns as a response to pressure overload have distinct hemodynamic profiles, cardiac function, and outcomes. The most common classification considers LV relative wall thickness and LV mass index to create 4 different groups. A new classification including also end-diastolic volume index has been recently proposed. AIM: To describe the prevalence of the newly identified remodeling patterns in patients with severe aortic stenosis and to evaluate their clinical relevance according to symptoms...
April 16, 2018: Echocardiography
https://www.readbyqxmd.com/read/29663059/fractionoptimizer-a-method-for-optimal-peptide-fractionation-in-bottom-up-proteomics
#15
Elizaveta M Solovyeva, Anna A Lobas, Arthur T Kopylov, Irina Y Ilina, Lev I Levitsky, Sergei A Moshkovskii, Mikhail V Gorshkov
Recent advances in mass spectrometry and separation technologies created the opportunities for deep proteome characterization using shotgun proteomics approaches. The "real world" sample complexity and high concentration range limit the sensitivity of this characterization. The common strategy for increasing the sensitivity is sample fractionation prior to analysis either at the protein or the peptide level. Typically, fractionation at the peptide level is performed using linear gradient high-performance liquid chromatography followed by uniform fraction collection...
April 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29663058/geochemical-wolframite-fingerprinting-the-likelihood-ratio-approach-for-laser-ablation-icp-ms-data
#16
Agnieszka Martyna, Hans-Eike Gäbler, Andreas Bahr, Grzegorz Zadora
Wolframite has been specified as a 'conflict mineral' by a U.S. Government Act, which obliges companies that use these minerals to report their origin. Minerals originating from conflict regions in the Democratic Republic of the Congo shall be excluded from the market as their illegal mining, trading, and taxation are supposed to fuel ongoing violent conflicts. The German Federal Institute for Geosciences and Natural Resources (BGR) developed a geochemical fingerprinting method for wolframite based on laser ablation inductively coupled plasma-mass spectrometry...
April 17, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29663056/application-of-asymmetric-flow-field-flow-fractionation-af4-and-multiangle-light-scattering-mals-for-the-evaluation-of-changes-in-the-product-molar-mass-during-pvp-b-pamps-synthesis
#17
Catalina Fuentes, Joel Castillo, Jose Vila, Lars Nilsson
The use of polymers for the delivery of drugs has increased dramatically in the last decade. To ensure the desired properties and functionality of such substances, adequate characterization in terms of the molar mass (M) and size is essential. The aim of this study was to evaluate the changes in the M and size of PVP-b-PAMPS when the amounts of the synthesis reactants in the two-step radical reaction were varied. The determination of the M and size distributions was performed by an asymmetric flow field-flow fractionation (AF4) system connected to multiangle light scattering (MALS) and differential refractive index (dRI) detectors...
April 16, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29661717/primary-breast-carcinomas-with-neuroendocrine-features-clinicopathological-features-and-analysis-of-tumor-growth-patterns-in-36-cases
#18
Canan Kelten Talu, Cem Leblebici, Tulin Kilicaslan Ozturk, Ezgi Hacihasanoglu, Sevim Baykal Koca, Zuhal Gucin
Primary breast carcinoma with neuroendocrine features (NEBC) is an uncommon tumor. In the classification of WHO 2012, these tumors were categorized as: 1- neuroendocrine tumor, well-differentiated; 2- neuroendocrine carcinoma, poorly differentiated/small cell carcinoma; and 3- invasive breast carcinoma with neuroendocrine differentiation. In this study, we reviewed NEBC except poorly differentiated/small cell carcinoma variant in order to define the morphological growth patterns and cytonuclear details of these tumors...
April 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661383/does-intranasal-dexmedetomidine-provide-adequate-plasma-concentrations-for-sedation-in-children-a-pharmacokinetic-study
#19
J W Miller, R Balyan, M Dong, M Mahmoud, J E Lam, J N Pratap, J R Paquin, B L Li, J P Spaeth, A Vinks, A W Loepke
BACKGROUND: Atomised intranasal dexmedetomidine administration is an attractive option when sedation is required for paediatric diagnostic procedures, as vascular access is not required. The risk of haemodynamic instability caused by dexmedetomidine necessitates better understanding of its pharmacokinetics in young children. To date, intranasal dexmedetomidine pharmacokinetics has only been studied in adults. METHODS: Eighteen paediatric patients received dexmedetomidine 1 or 2 μg kg-1 intranasally or 1 μg kg-1 i...
May 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29661196/the-women-s-heart-health-programme-a-pilot-trial-of-sex-specific-cardiovascular-management
#20
Ting Ting Low, Siew Pang Chan, Shin Hnin Wai, Zhou Ang, Kyu Kyu, Kim Yee Lee, Anne Ching, Sarah Comer, Naomi Qiu Pin Tan, Elizabeth Grace Hui En Thong, Tracy Nang, Mohan Dutta, Carolyn S P Lam
BACKGROUND: There is increasing knowledge of sex-specific differences in cardiovascular disease and recognition of sex disparities in management. In our study, we investigated whether a cardiovascular programme tailored to the specific needs of women could lead to improved outcomes. METHODS: We randomised 100 female patients to receive cardiology follow-up with the conventional sex-neutral cardiac programme (control), or the sex-tailored Women's Heart Health Programme (intervention)...
April 16, 2018: BMC Women's Health
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