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https://www.readbyqxmd.com/read/28732312/drug-eluting-scaffold-inhibited-in-vivo-pancreatic-tumorigenesis-by-engaging-murine-ccr4-cd8-t-cells
#1
Qian Zhan, Baiyong Shen, Yuan Fang, Xiaxing Deng, Hao Chen, Jiabin Jin, Chenghong Peng, Hongwei Li
CCL17 is well known for its ability to engage CCR4(+)CD8(+) T cells, which have been shown to play a critical role in preventing tumorigenesis. In this study, we attempted to inhibit in vivo pancreatic tumorigenesis by engaging murine CCR4(+)CD8(+) T cells through a drug-eluting scaffold with a payload of CCL17. The drug-eluting scaffold was fabricated by electrospinning polyglyconate and porcine gelatin. The electrospun scaffold featured randomly distributed non-woven fibers with diameters ranging from 1μm to 4μm...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28732136/an-approach-to-estimate-the-activation-energies-of-fragmentation-occurring-in-quadrupole-collision-cell-of-the-mass-spectrometer
#2
Ákos Kuki, Lajos Nagy, Miklós Zsuga, Sándor Kéki
The classical semi-quantitative Rice-Ramsperger-Kassel (RRK) theory was used for the calculation of the internal energy dependent reaction rate coefficient of the collision-induced dissociation (CID) reaction in tandem mass spectrometry (MS/MS). The survival yield (SY) was determined by the reaction rate equation for the unimolecular dissociation of the precursor ion. The parameters of the rate equation and the RRK model were approximated based on the instrumental conditions. We used the RRK equation for the description of the basic behavior of the fragmentation reactions and for the estimation of the internal energy of the precursor ion...
July 21, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28731323/analyzing-liposomal-drug-delivery-systems-in-three-dimensional-cell-culture-models-using-maldi-imaging-mass-spectrometry
#3
Jessica K Lukowski, Eric M Weaver, Amanda B Hummon
Cancer chemotherapeutics often fail to reach all diseased cells. To help solve this problem, researchers are investigating novel drug delivery systems. Liposomes are an attractive option due to their low toxicity, high biocompatibility, and potential to carry a large amount of a drug to the tumor site, all while avoiding being eliminated from the body. This study evaluates the penetration of doxorubicin-encased liposomes into three-dimensional cell cultures, or spheroids. Liposomes composed of lipids containing head groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cholesterol were created by extrusion...
July 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28731295/biogeochemistry-of-lead-its-release-to-the-environment-and-chemical-speciation
#4
Jay T Cullen, Jason McAlister
Lead (Pb) is a metal that is not essential for life processes and proves acutely toxic to most organisms. Compared to other metals Pb is rather immobile in the environment but still its biogeochemical cycling is greatly perturbed by human activities. In this review we present a summary of information describing the physical and chemical properties of Pb, its distribution in crustal materials, and the processes, both natural and anthropogenic, that contribute to the metal's mobilization in the biosphere. The relatively high volatility of Pb metal, low melting point, its large ionic radius, and its chemical speciation in aquatic systems contributes to its redistribution by anthropogenic and natural processes...
April 10, 2017: Metal Ions in Life Sciences
https://www.readbyqxmd.com/read/28730864/automatic-rbg-depth-pressure-anthropometric-analysis-and-individualised-sleep-solution-prescription
#5
Jordi Esquirol Caussa, Cristina Palmero Cantariño, Vanessa Bayo Tallón, Miquel Àngel Cos Morera, Sergio Escalera Domínguez, David Sánchez, Maider Sánchez Padilla, Noelia Serrano Domínguez, Mireia Relats Vilageliu
INTRODUCTION: Sleep surfaces must adapt to individual somatotypic features to maintain a comfortable, convenient and healthy sleep, preventing diseases and injuries. Individually determining the most adequate rest surface can often be a complex and subjective question. OBJECTIVES: To design and validate an automatic multimodal somatotype determination model to automatically recommend an individually designed mattress-topper-pillow combination. METHODS: Design and validation of an automated prescription model for an individualised sleep system is performed through a single-image 2 D-3 D analysis and body pressure distribution, to objectively determine optimal individual sleep surfaces combining five different mattress densities, three different toppers and three cervical pillows...
July 21, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28730511/intermediate-molecular-mass-hyaluronan-and-cd44-receptor-interactions-enhance-neutrophil-phagocytosis-and-il-8-production-via-p38-and-erk1-2-mapk-signalling-pathways
#6
Cheng-Hsun Lu, Chia-Huei Lin, Ko-Jen Li, Chieh-Yu Shen, Cheng-Han Wu, Yu-Min Kuo, Ting-Syuan Lin, Chia-Li Yu, Song-Chou Hsieh
CD44 is a common leukocyte adhesion molecule expressed on the surface of various cells. Hyaluronan (HA), the natural ligand of CD44, is a simple repeated disaccharide with variable molecular mass that is widely distributed on cell surfaces and the connective tissue matrix. The binding of small molecular mass HA (SMM-HA, MW < 80 kDa) to CD44 on immune-related cells elicits cell proliferation, differentiation, and cytokine production. However, the effects and molecular basis of intermediate molecular mass HA (IMM-HA, MW ≈ 500 kDa)-CD44 interactions on polymorphonuclear neutrophil (PMN) functions have not been elucidated...
July 20, 2017: Inflammation
https://www.readbyqxmd.com/read/28730339/breast-cancer-neoplastic-seeding-in-the-setting-of-image-guided-needle-biopsies-of-the-breast
#7
REVIEW
Lumarie Santiago, Beatriz E Adrada, Monica L Huang, Wei Wei, Rosalind P Candelaria
PURPOSE: To identify clinicopathologic, technical, and imaging features associated with neoplastic seeding (NS) following image-guided needle breast biopsy. METHODS: We performed an institutional review board-approved retrospective review of patients presenting with a new diagnosis of breast cancer or suspicious breast findings requiring biopsy with subsequent diagnosis of NS. The time from biopsy to NS diagnosis was calculated. Histology, grade, estrogen receptor (ER) status, progesterone receptor (PR) status, HER2 status, T category, and N category were recorded...
July 20, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28730210/a-layer-by-layer-assembled-mos2-thin-film-as-an-efficient-platform-for-laser-desorption-ionization-mass-spectrometry-analysis-of-small-molecules
#8
Young-Kwan Kim, Li-Sheng Wang, Ryan Landis, Chang Soo Kim, Richard W Vachet, Vincent M Rotello
A chip-based platform for laser desorption/ionization mass spectrometry (LDI-MS) analysis of small molecules was developed by utilizing layer-by-layer (LBL) assembly of MoS2 nanoflakes and polyallylamine on an arbitrary substrate. The LDI-MS efficiency of small molecules on MoS2 films increased as a function of LBL assembly cycles until reaching a saturation point. The optimized MoS2 nanoflake film exhibits high LDI-MS efficiency, salt tolerance, reusability and uniform ionic signal distribution, and its performance was further enhanced by surface modification with perfluoroalkanes mimicking a clathrate nanostructure...
July 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28728141/estimates-of-soil-ingestion-in-a-population-of-chinese-children
#9
Chunye Lin, Beibei Wang, Xiaoyong Cui, Dongqun Xu, Hongguang Cheng, Qin Wang, Jin Ma, Tuanyao Chai, Xiaoli Duan, Xitao Liu, Junwei Ma, Xuan Zhang, Yanzhong Liu
BACKGROUND: China's soil pollution poses serious health risks. However, data regarding the soil ingestion rate (SIR) of the Chinese population, which is critical to assessing associated health risks, are lacking. OBJECTIVES: We estimated soil ingestion of 177 Chinese children from Guangdong, Hubei, and Gansu Provinces. METHODS: We conducted this investigation by employing a tracer mass-balance method. We collected a duplicate of all food consumed and all feces and urine excreted on 1 d () and over 3 consecutive d (), as well as soil samples from play areas and drinking-water samples...
July 5, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28727937/preoperative-short-form-health-survey-score-is-predictive-of-return-to-play-and-minimal-clinically-important-difference-at-a-minimum-2-year-follow-up-after-anterior-cruciate-ligament-reconstruction
#10
Benedict U Nwachukwu, Brenda Chang, Pramod B Voleti, Patricia Berkanish, Matthew R Cohn, David W Altchek, Answorth A Allen, Riley J Williams
BACKGROUND: There is increased interest in understanding the preoperative determinants of postoperative outcomes. Return to play (RTP) and the patient-reported minimal clinically important difference (MCID) are useful measures of postoperative outcomes after anterior cruciate ligament reconstruction (ACLR). PURPOSE: To define the MCID after ACLR and to investigate the role of preoperative outcome scores for predicting the MCID and RTP after ACLR. STUDY DESIGN: Case-control study; Level of evidence, 3...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28727855/association-of-apoe-gene-polymorphism-with-lipid-profile-and-coronary-artery-disease-in-afro-caribbeans
#11
Laurent Larifla, Christophe Armand, Jacqueline Bangou, Anne Blanchet-Deverly, Patrick Numeric, Christiane Fonteau, Carl-Thony Michel, Séverine Ferdinand, Véronique Bourrhis, Fritz-Line Vélayoudom-Céphise
OBJECTIVES: Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors. METHODS: We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28727500/risk-stratification-of-adnexal-cysts-and-cystic-masses-clinical-performance-of-society-of-radiologists-in-ultrasound-guidelines
#12
Katherine E Maturen, Alexander D Blaty, Ashish P Wasnik, Krupa Patel-Lippmann, Jessica B Robbins, Lisa Barroilhet, Laura B Huffman, Elizabeth A Sadowski
Purpose To evaluate the performance of the 2010 Society of Radiologists in Ultrasound (SRU) consensus guidelines in the risk stratification of symptomatic and asymptomatic adnexal cysts. Materials and Methods An institutional review board-approved retrospective review was performed, including adnexal cysts detected with ultrasonography (US) with surgical diagnosis or at least 2 years of imaging or clinical follow-up, from January to June 2011. SRU management recommendations were scored as 0, no follow-up; 1, US follow-up; 2, magnetic resonance (MR) imaging follow-up; and 3, surgical evaluation...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28727423/seasonal-variation-of-terrigenous-pahs-along-the-marginal-seas-of-china-input-phase-partitioning-ocean-current-transport
#13
Miao-Lei Ya, Xin-Hong Wang, Yu-Ling Wu, Yong-Yu Li, Jing-Ming Yan, Chao Fang, Yan-Yan Zhao, Ran-Ran Qian, Xiao-Long Lin
To study the spatial distributions and seasonal differences of concentrations, source identification, and phase partitioning of polycyclic aromatic hydrocarbons (PAHs) in the surface water, intensive sampling was carried out along the marginal seas of China in four seasons. In the northern South China Sea (SCS), the highest PAH levels occurred in summer (July to August) and autumn (October to November). In the East China Sea (ECS) and the Yellow Sea, the highest occurred in summer (August) and winter (December)...
July 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28727418/combining-tof-sims-imaging-mass-spectrometry-and-cars-microspectroscopy-reveals-lipid-patterns-reminiscent-of-gene-expression-patterns-in-the-wing-imaginal-disc-of-drosophila-melanogaster
#14
Florian Marty, Gianluca Rago, Donald F Smith, Xiaoli Gao, Gert B Eijkel, Luke MacAleese, Mischa Bonn, Erich Brunner, Konrad Basler, Ron M A Heeren
Using label-free ToF-SIMS imaging mass spectrometry, we generated a map of small molecules differentially expressed in the Drosophila wing imaginal disc. The distributions of these moieties were in line with gene expression patterns observed during wing imaginal disc development. Combining ToF-SIMS imaging and coherent anti-Stokes Raman spectroscopy (CARS) microspectroscopy allowed us to locally identify acylglycerols as the main constituents of the pattern differentiating the future body wall tissue from the wing blade tissue...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28727417/oxygen-dependent-lipid-profiles-of-3d-cultured-human-chondrocytes-revealed-by-maldi-msi
#15
Brenda Bakker, Gert B Eijkel, Ron M A Heeren, Marcel Karperien, Janine N Post, Berta Cillero Pastor
Articular cartilage is exposed to a gradient of oxygen levels ranging from 5% at the surface to 1% in the deepest layers. While most cartilage research is performed in supraphysiological oxygen levels (19-21%), culturing chondrocytes under hypoxic oxygen levels (≤ 8%) promotes the chondrogenic phenotype. Exposure of cells to various oxygen levels alters their lipid metabolism, but detailed studies examining how hypoxia affects lipid metabolism in chondrocytes are lacking. To better understand the chondrocyte's behavior in response to oxygen we cultured 3D pellets of human primary chondrocytes in normoxia (20% oxygen) and hypoxia (2...
July 20, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28727342/-obesity-fat-and-bones-friends-or-foes
#16
Emmanuel Biver
Low fat mass is associated with an increased risk of fracture because of low bone mineral density (BMD) and altered bone micro-architecture. Conversely, overweight and obese patients also have an increased risk of fracture, particularly of the humerus and ankle, despite greater BMD. Visceral abdominal fat, which is the most metabolically active, may be associated with poorer quality of bone tissue properties, as suggested in diabetes. Other factors may contribute to higher fracture risk in overweight patients, notably higher frequency of falls and lower bioavailability of vitamin D stoked in fat...
April 19, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28727072/the-equine-glucose-dependent-insulinotropic-polypeptide-receptor-a-potential-therapeutic-target-for-insulin-dysregulation
#17
M H Kheder, M N Sillence, L M Bryant, M A de Laat
Metabolic disease is a significant problem that causes a range of species-specific comorbidities. Recently, a better understanding of glucose-dependent insulinotropic polypeptide (GIP) biology has led to the suggestion that inhibiting its action may attenuate obesity in several species. In horses, antagonism of GIP may also reduce hyperinsulinemia, which leads to insulin-associated laminitis, a painful comorbidity unique to this species. However, little is known about GIP in horses. The aims of this study were to examine the tissue distribution of equine GIP receptors (eGIPR), to determine whether eGIPR can be blocked using a GIP antagonist not tested previously in horses, and to establish whether there is any association between GIP concentrations and body mass in this species...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726666/-pathomorphological-changes-under-latent-mastoiditis
#18
Kh Chitadze, T Jorbenadze, M Adamia
In our opinion it is caused by incomplete awareness of the distribution of pathological process and the character of morphological changes in the patients. In this regard, we studied structural changes in the soft and bone tissue taken from various cavities of the middle ear system. Operating material was formed in paraffin after the fixation and proper processing. We proceed with decalcification of bone tissues in 15-20% nitric acid. We painted 5-6 mm thick peels prepared on the rotating microtome with hematoxylin and eosin...
June 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28725442/identification-of-dust-storm-origin-in-south-west-of-iran
#19
Parya Broomandi, Bahram Dabir, Babak Bonakdarpour, Yousef Rashidi
BACKGROUND: Deserts are the main sources of emitted dust, and are highly responsive to wind erosion. Low content of soil moisture and lack of vegetation cover lead to fine particle's release. One of the semi-arid bare lands in Iran, located in the South-West of Iran in Khoozestan province, was selected to investigate Sand and Dust storm potential. METHODS: This paper focused on the metrological parameters of the sampling site, their changes and the relationship between these changes and dust storm occurrence, estimation of Reconaissance Drought Index, the Atterberg limits of soil samples and their relation with soil erosion ability, the chemical composition, size distribution of soil and airborne dust samples, and estimation of vertical mass flux by COMSALT through considering the effect of saffman force and interparticle cohesion forces during warm period (April-September) in 2010...
2017: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/28725376/moving-south-effects-of-water-temperatures-on-the-larval-development-of-invasive-cane-toads-rhinella-marina-in-cool-temperate-australia
#20
Uditha Wijethunga, Matthew Greenlees, Richard Shine
The distributional limits of many ectothermic species are set by thermal tolerances of early-developmental stages in the life history; embryos and larvae often are less able to buffer environmental variation than are conspecific adults. In pond-breeding amphibians, for example, cold water may constrain viability of eggs and larvae, even if adults can find suitable thermal conditions in terrestrial niches. Invasive species provide robust model systems for exploring these questions, because we can quantify thermal challenges at the expanding range edge (from field surveys) and larval responses to thermal conditions (in the laboratory)...
October 2016: Ecology and Evolution
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