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https://www.readbyqxmd.com/read/28098848/identification-of-phenolic-compounds-from-hancornia-speciosa-apocynaceae-leaves-by-uhplc-orbitrap-hrms
#1
Katherine Xavier Bastos, Clarice Noleto Dias, Yuri Mangueira Nascimento, Marcelo Sobral da Silva, Silvana Maria Zucolotto Langassner, Ludger A Wessjohann, Josean Fechine Tavares
Apocynaceae is a botanical family distributed mainly in tropical and subtropical regions of the world. In Brazil, they comprise about 90 genera and 850 species, inhabiting various types of vegetation. Within this large botanical family, the genus Hancornia is considered monotypic, with its only species Hancornia speciosa Gomes. Antihypertensive, antidiabetic, and antiviral activities are described for this species. Despite having been the target of some studies, knowledge of its chemical composition is still limited...
January 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098799/occurrence-of-emerging-micropollutants-in-water-systems-in-gauteng-mpumalanga-and-north-west-provinces-south-africa
#2
Elijah M M Wanda, Hlengilizwe Nyoni, Bhekie B Mamba, Titus A M Msagati
The ubiquitous occurrence of emerging micropollutants (EMPs) in water is an issue of growing environmental-health concern worldwide. However, there remains a paucity of data regarding their levels and occurrence in water. This study determined the occurrence of EMPs namely: carbamazepine (CBZ), galaxolide (HHCB), caffeine (CAF), tonalide (AHTN), 4-nonylphenol (NP), and bisphenol A (BPA) in water from Gauteng, Mpumalanga, and North West provinces, South Africa using comprehensive two-dimensional gas chromatography coupled to high resolution time-of-flight mass spectrometry (GCxGC-HRTOFMS)...
January 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28098598/science-of-intracrinology-in-postmenopausal-women
#3
Fernand Labrie, Alain Bélanger, Georges Pelletier, Céline Martel, David F Archer, Wulf H Utian
OBJECTIVE: To illustrate the marked differences between classical endocrinology that distributes hormones to all tissues of the body through the bloodstream and the science of intracrinology, whereby each cell of each peripheral tissue makes a small and appropriate amount of estrogens and androgens from the inactive precursor dehydroepiandrosterone (DHEA), DHEA being mainly of adrenal origin. Because only the inactivated sex steroids are released in the blood, influence in the other tissues is avoided...
January 16, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28098178/lithium-accumulates-in-neurogenic-brain-regions-as-revealed-by-high-resolution-ion-imaging
#4
Giulia Zanni, Wojciech Michno, Elena Di Martino, Anna Tjärnlund-Wolf, Jean Pettersson, Charlotte Elizabeth Mason, Gustaf Hellspong, Klas Blomgren, Jörg Hanrieder
Lithium (Li) is a potent mood stabilizer and displays neuroprotective and neurogenic properties. Despite extensive investigations, the mechanisms of action have not been fully elucidated, especially in the juvenile, developing brain. Here we characterized lithium distribution in the juvenile mouse brain during 28 days of continuous treatment that result in clinically relevant serum concentrations. By using Time-of-Flight Secondary Ion Mass Spectrometry- (ToF-SIMS) based imaging we were able to delineate temporospatial lithium profile throughout the brain and concurrent distribution of endogenous lipids with high chemical specificity and spatial resolution...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28098107/knowledge-and-attitude-towards-organ-donation-among-adult-population-in-al-kharj-saudi-arabia
#5
Sandeep Agrawal, Saud Binsaleem, Mohammed Al-Homrani, Abdullaziz Al-Juhayim, Abdullah Al-Harbi
Organ transplantation is a lifesaving treatment for patients with end-stage organ failure. Despite the advanced medical science and technology, shortage of organs had led to a growing gap between the demand for organs and the number of donors. With a limited number of studies on the subject and based on those findings, the public knowledge and attitudes must be assessed to understand more clearly that why many people are opposing donating their organs in Saudi Arabia. The objective of our study was to assess the knowledge and attitude of the adult population toward organ donation in Saudi Arabia...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28097839/nutritional-assessment-of-a-population-with-a-history-of-childhood-craniopharyngioma-seen-at-hospital-prof-dr-juan-p-garrahan
#6
Carolina Caminiti, Carola Saure, Ilanit Bomer, Mercedes Brea, Javier González Ramos
INTRODUCTION: Craniopharyngiomas are histologically benign malformations located between the pituitary and hypothalamus that may affect key hormone secretion for endocrine regulation and satiety modulation. Although this is a relatively benign disease, the combination of severe hypothalamic obesity and associated comorbidities results in a reduced quality of life. OBJECTIVE: To assess the nutritional status of patients after craniopharyngioma surgery. POPULATION AND METHODS: Patients younger than 21 years old at the time of the study who required craniopharyngioma surgery at Hospital de Pediatr...
February 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28097665/pharmacokinetics-and-selected-pharmacodynamics-of-romifidine-following-low-dose-intravenous-administration-in-combination-with-exercise-to-quarter-horses
#7
H K Knych, S D Stanley, D S McKemie, S J Steinmetz
Romifidine is an alpha-2 adrenergic agonist used for sedation and analgesia in horses. As it is a prohibited substance, its purported use at low doses in performance horses necessitates further study. The primary goal of the study reported here was to describe the serum concentrations and pharmacokinetics of romifidine following low-dose administration immediately prior to exercise, utilizing a highly sensitive liquid chromatography-tandem mass spectrometry assay that is currently employed in many drug testing laboratories...
January 17, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28096887/thylakoids-reduce-body-fat-and-fat-cell-size-by-binding-to-dietary-fat-making-it-less-available-for-absorption-in-high-fat-fed-mice
#8
Karin G Stenkula, Eva-Lena Stenblom, Caroline Montelius, Emil Egecioglu, Charlotte Erlanson-Albertsson
BACKGROUND: Dietary thylakoids derived from spinach have beneficial effects on body fat accumulation and blood lipids as demonstrated in humans and rodents. Important mechanisms established include delayed fat digestion in the intestine, without causing steatorrhea, and increased fatty acid oxidation in intestinal cells. The objective of our study was to elucidate if increased fecal fat excretion is an important mechanism to normalize adipose tissue metabolism during high-fat feeding in mice supplemented with thylakoids...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28096625/the-effect-of-dietary-supplementation-of-salts-of-organic-acid-on-production-performance-of-laying-hens
#9
Ravinder Dahiya, Raj Singh Berwal, Sajjan Sihag, Chandrashekhar Santosh Patil, Lalit
AIM: An experiment was conducted to evaluate the effect of supplementing different levels of salts of organic acid in the laying hen's diet on their production performance and egg quality parameters during a period of 16-week. MATERIALS AND METHODS: A total of 140 white leghorn laying hens at 24 weeks of age were randomly distributed to seven dietary treatment groups, i.e. T1 (control), T2 (0.5% sodium-butyrate), T3 (1.0% sodium-butyrate), T4 (1.5% sodium-butyrate), T5 (0...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28095969/body-fat-distribution-ratios-and-obstructive-sleep-apnea-severity-in-youth-with-obesity
#10
Amy Glicksman, Stasia Hadjiyannakis, Nicholas Barrowman, Scott Walker, Lynda Hoey, Sherri Lynne Katz
STUDY OBJECTIVES: Obesity and regional fat distribution, measured by neck fat mass percentage using dual-energy X-ray absorptiometry (DXA), correlate with obstructive sleep apnea (OSA) severity in adults. In obese children, neck-to-waist-circumference ratio predicts OSA. This study examined associations between body fat percentage and distribution and sleep-disordered breathing (SDB) severity in obese youth, measured with DXA. METHODS: Cross-sectional retrospective study conducted at a tertiary children's hospital...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28095873/physical-integrity-and-residual-bio-efficacy-of-used-llins-in-three-cities-of-the-south-west-region-of-cameroon-4%C3%A2-years-after-the-first-national-mass-distribution-campaign
#11
Stravensky T Boussougou-Sambe, Parfait Awono-Ambene, Geraud C T Tasse, Josiane Etang, Jerome A Binyang, Lynda D Nouage, Gaston Wamba, Peter Enyong, Eric B Fokam
BACKGROUND: Long-lasting insecticidal nets (LLINs) are effective tools at reducing malaria transmission. In Cameroon, following the first national mass distribution campaign in 2011, there has been no follow up on the efficacy of LLINs distributed. The aim of this report is to assess the physical integrity and insecticidal potency of LLINs distributed in three cities with contrasting socio economic status (SES) and to evaluate the use and care for bed nets owned by individuals. METHODS: The study was conducted in Limbe, Tiko and Buea three localities in the Fako division of the South West Region of Cameroon...
January 17, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28095202/interpretation-of-the-precision-matrix-and-its-application-in-estimating-sparse-brain-connectivity-during-sleep-spindles-from-human-electrocorticography-recordings
#12
Anup Das, Aaron L Sampson, Claudia Lainscsek, Lyle Muller, Wutu Lin, John C Doyle, Sydney S Cash, Eric Halgren, Terrence J Sejnowski
The correlation method from brain imaging has been used to estimate functional connectivity in the human brain. However, brain regions might show very high correlation even when the two regions are not directly connected due to the strong interaction of the two regions with common input from a third region. One previously proposed solution to this problem is to use a sparse regularized inverse covariance matrix or precision matrix (SRPM) assuming that the connectivity structure is sparse. This method yields partial correlations to measure strong direct interactions between pairs of regions while simultaneously removing the influence of the rest of the regions, thus identifying regions that are conditionally independent...
January 17, 2017: Neural Computation
https://www.readbyqxmd.com/read/28094297/high-throughput-quantitation-of-inorganic-nanoparticle-biodistribution-at-the-single-cell-level-using-mass-cytometry
#13
Yu-Sang Sabrina Yang, Prabhani U Atukorale, Kelly D Moynihan, Ahmet Bekdemir, Kavya Rakhra, Li Tang, Francesco Stellacci, Darrell J Irvine
Inorganic nanoparticles (NPs) are studied as drug carriers, radiosensitizers and imaging agents, and characterizing nanoparticle biodistribution is essential for evaluating their efficacy and safety. Tracking NPs at the single-cell level with current technologies is complicated by the lack of reliable methods to stably label particles over extended durations in vivo. Here we demonstrate that mass cytometry by time-of-flight provides a label-free approach for inorganic nanoparticle quantitation in cells. Furthermore, mass cytometry can enumerate AuNPs with a lower detection limit of ∼10 AuNPs (3 nm core size) in a single cell with tandem multiparameter cellular phenotyping...
January 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28093409/deuterater-a-tool-for-quantifying-peptide-isotope-precision-and-kinetic-proteomics
#14
Bradley C Naylor, Michael T Porter, Elise Wilson, Adam Herring, Spencer Lofthouse, Austin Hannemann, Stephen R Piccolo, Alan L Rockwood, John C Price
MOTIVATION: Using mass spectrometry to measure the concentration and turnover of the individual proteins in a proteome, enables the calculation of individual synthesis and degradation rates for each protein. Software to analyze concentration is readily available, but software to analyze turnover is lacking. Data analysis workflows typically don't access the full breadth of information about instrument precision and accuracy that is present in each peptide isotopic envelope measurement...
January 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28093371/sonographically-guided-knee-meniscus-injections-feasibility-techniques-and-validation
#15
Michael R Baria, Jacob L Sellon, Dan Lueders, Jay Smith
BACKGROUND: There is a growing interest in the use of biologic agents such as platelet-rich plasma and mesenchymal stem/stromal cells to treat musculoskeletal injuries, including meniscal tears. Although prior research has documented the role of diagnostic ultrasound to evaluate meniscal tears, sonographically guided (SG) techniques to specifically deliver therapeutic agents into the meniscus have not been described. OBJECTIVE: To describe and validate SG injection techniques for the body and posterior horn of the medial and lateral meniscus...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28092409/quantification-of-brown-and-white-adipose-tissue-based-on-gaussian-mixture-model-using-water-fat-and-t2-mri-in-adolescents
#16
Steve C N Hui, Jacky K L Ko, Teng Zhang, Lin Shi, David K W Yeung, Defeng Wang, Queenie Chan, Winnie C W Chu
PURPOSE: To develop a technique for the separation and quantification of brown adipose tissue (BAT) and white adipose tissue (WAT) using fat fraction and T2* intensity based on the Gaussian mixture model (GMM). MATERIALS AND METHODS: Chemical-shift water-fat and T2* images were acquired at the neck, supraclavicular, interscapular, and paravertebral regions in 24 volunteers (Obese: n = 12, female/male = 6/6, body mass index [BMI] = 31.3 ± 2.3 kg/m(2) , age = 16...
January 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28091562/unravelling-a-simple-method-for-the-low-temperature-synthesis-of-silicon-nanocrystals-and-monolithic-nanocrystalline-thin-films
#17
Ka-Hyun Kim, Erik V Johnson, Andrey G Kazanskii, Mark V Khenkin, Pere Roca I Cabarrocas
In this work, we present new results on the plasma processing and structure of hydrogenated polymorphous silicon (pm-Si:H) thin films. pm-Si:H thin films consist of a low volume fraction of silicon nanocrystals embedded in a silicon matrix with medium range order, and they possess this morphology as a significant contribution to their growth comes from the impact on the substrate of silicon clusters and nanocrystals synthesized in the plasma. Quadrupole mass spectrometry, ion flux measurements, and material characterization by transmission electron microscopy (TEM) and atomic force microscopy all provide insight on the contribution to the growth by silicon nanocrystals during PECVD deposition...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091127/amino-modified-polystyrene-nanoparticles-affect-signalling-pathways-of-the-sea-urchin-paracentrotus-lividus-embryos
#18
Annalisa Pinsino, Elisa Bergami, Camilla Della Torre, Maria Luisa Vannuccini, Piero Addis, Marco Secci, Kenneth A Dawson, Valeria Matranga, Ilaria Corsi
Polystyrene nanoparticles have been shown to pose serious risk to marine organisms including sea urchin embryos based on their surface properties and consequently behaviour in natural sea water. The aim of this study is to investigate the toxicity pathways of amino polystyrene nanoparticles (PS-NH2, 50 nm) in Paracentrotus lividus embryos in terms of development and signalling at both protein and gene levels. Two sub-lethal concentrations of 3 and 4 µg/mL of PS-NH2 were used to expose sea urchin embryos in natural sea water (PS-NH2 as aggregates of 143 ± 5 nm)...
January 16, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28090346/a-gwas-follow-up-of-obesity-related-snps-in-sypl2-reveals-sex-specific-association-with-hip-circumference
#19
J de Toro-Martín, F Guénard, A Tchernof, Y Deshaies, L Pérusse, S Biron, O Lescelleur, L Biertho, S Marceau, M-C Vohl
OBJECTIVE: A novel single-nucleotide polymorphism (SNP) associated with morbid obesity was recently identified by exome sequencing. The purpose of this study was to follow up this low-frequency coding SNP located within the SYPL2 locus and associated with body mass index in order to reveal novel associations with obesity-related traits. METHODS: The body mass index-associated SNP (rs62623713 A>G [chr1:109476817/hg19]) and two tagging SNPs within the SYPL2 locus, rs9661614 T>C (chr1:109479215) and rs485660 G>A (chr1:109480810), were genotyped in the obesity (n = 3,017) and the infogene (n = 676) cohorts, which were further combined, leading to a larger cohort of 3,693 individuals...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28089717/persistent-organic-pollutants-pops-in-human-follicular-fluid-and-in-vitro-fertilization-outcomes-a-pilot-study
#20
Michael S Bloom, Victor Y Fujimoto, Robin Storm, Li Zhang, Celeste D Butts, Diana Sollohub, Robert L Jansing
Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF)...
January 9, 2017: Reproductive Toxicology
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