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https://www.readbyqxmd.com/read/28822218/locally-produced-xenin-and-the-neurotensinergic-system-in-pancreatic-islet-function-and-%C3%AE-cell-survival
#1
Dawood Khan, Srividya Vasu, R Charlotte Moffett, Victor A Gault, Peter R Flatt, Nigel Irwin
Modulation of neuropeptide receptors is important for pancreatic β-cell function. Here, islet distribution and effects of the neurotensin (NT) receptor modulators, xenin and NT, was examined. Xenin, but not NT, significantly improved glucose disposal and insulin secretion, in mice. However, both peptides stimulated insulin secretion from rodent β-cells at 5.6 mM glucose, with xenin having similar insulinotropic actions at 16.7 mM glucose. In contrast, NT inhibited glucose-induced insulin secretion. Similar observations were made in human 1...
August 28, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28822067/association-between-serum-osteocalcin-and-body-mass-index-a-systematic-review-and-meta-analysis
#2
Hamed Kord-Varkaneh, Kurosh Djafarian, Masoud Khorshidi, Sakineh Shab-Bidar
PURPOSE: Osteocalcin is considered as a bone-derived hormone affecting on the body fat distribution and body mass index. Several cross-sectional studies have investigated the association between serum osteocalcin and body mass index. The aim of this study was to summarize the evidence on the relationship between serum osteocalcin and body mass index. METHODS: We conducted a complete search up to November 2016 in PubMed and SCOPUS and reviewed reference list of all relevant articles and reviews...
August 18, 2017: Endocrine
https://www.readbyqxmd.com/read/28822040/the-effect-of-sources-and-air-mass-transport-on-the-variability-of-trace-element-deposition-in-central-poland-a-cluster-based-approach
#3
Patrycja Siudek, Marcin Frankowski
Measurements of trace element (As, Cu, Cd, Cr, Ni, Pb, Zn) deposition fluxes were conducted simultaneously in two contrasted environments, i.e., urban and forest, between April 2013 and October 2014. This was the first such project in central Poland, aimed at long-term observations of trace elements in the atmosphere and their distribution, transport, and deposition pattern. The receptor sites were different in terms of local meteorological conditions, emission potential, and distance to major anthropogenic sources...
August 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28821838/biogeography-shaped-the-metabolome-of-the-genus-espeletia-a-phytochemical-perspective-on-an-andean-adaptive-radiation
#4
Guillermo F Padilla-González, Mauricio Diazgranados, Fernando B Da Costa
The páramo ecosystem has the highest rate of diversification across plant lineages on earth, of which the genus Espeletia (Asteraceae) is a prime example. The current distribution and molecular phylogeny of Espeletia suggest the influence of Andean geography and past climatic fluctuations on the diversification of this genus. However, molecular markers have failed to reveal subtle biogeographical trends in Espeletia diversification, and metabolomic evidence for allopatric segregation in plants has never been reported...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821789/isolation-characterization-and-toxicological-potential-of-alternaria-mycotoxins-tea-aoh-and-ame-in-different-alternaria-species-from-various-regions-of-india
#5
Mukesh Meena, Prashant Swapnil, R S Upadhyay
Alternaria species produce various sorts of toxic metabolites during their active growth and causes severe diseases in many plants by limiting their productivity. These toxic metabolites incorporate various mycotoxins comprising of dibenzo-α-pyrone and some tetramic acid derivatives. In this study, we have screened out total 48 isolates of Alternaria from different plants belonging to different locations in India, on the basis of their pathogenic nature. Pathogenicity testing of these 48 strains on susceptible tomato variety (CO-3) showed 27...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821292/the-relationship-between-obesity-and-body-compositions-with-respect-to-the-timing-of-puberty-in-chongqing-adolescents-a-cross-sectional-study
#6
Fang He, Peiyu Guan, Qin Liu, Donna Crabtree, Linli Peng, Hong Wang
BACKGROUND: It is well known that excess adiposity during childhood may influence pubertal development. However, the extent to which body compositions vary in throughout puberty in boys and girls is currently unknown. The aim of this study was to investigate whether obesity and body compositions correlate with the timing of puberty in boys and girls. METHODS: By random cluster sampling, our study analyzed data from 1472 students (690 girls, 782 boys) aged 6-17 years from two schools in the Chongqing area...
August 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28821028/targeted-gene-delivery-of-polyethyleneimine-grafted-chitosan-with-rgd-dendrimer-peptide-in-%C3%AE-v%C3%AE-3-integrin-overexpressing-tumor-cells
#7
Young-Min Kim, Seong-Cheol Park, Mi-Kyeong Jang
The safe and effective delivery of genetic material into cells is a necessary factor for gene therapy. Although a wide range of materials, methods, and combinations have been reported, successful gene therapy has been limited. In the present study, a targeted gene carrier for αvβ3 integrin-overexpressing tumor cells was designed using widely applied materials containing water soluble chitosan (WSC), RGD peptide, and polyethyleneimine (PEI). The physiological characteristics, in vitro targeted gene transfection, cytotoxicity, blood-compatibility, and cellular distributions were investigated...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820707/prevalence-of-strongyloides-stercoralis-and-other-intestinal-parasite-infections-in-school-children-in-a-rural-area-of-angola-a-cross-sectional-study
#8
María Luisa Ruíz de Alegría Aznar, Karen Colmenares, Mateu Espasa, Arancha Amor, Isabel Lopez, Arlette Ninda, Joaquina Kanjala, Domingas Guilherme, Elena Sulleiro, Begoña Barriga, Eva Gil, Fernando Salvador, Cristina Bocanegra, Teresa López, Milagros Moreno, Israel Molina
Strongyloides stercoralis is widely distributed in the tropics and subtropics. The aim of this study was to determine the prevalence of S. stercoralis and other intestinal parasites and identify the risk factors for infection with S. stercoralis in a rural area of Angola. A cross-sectional study was conducted in school-age children (SAC) in Cubal, Angola. A questionnaire collecting clinical and epidemiological variables was used, and two stool samples were collected. A concentration technique (Ritchie) and a technique for detection of larvae migration (Baermann) were performed...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820593/structure-of-dynamic-taxol-stabilized-and-gmppcp-stabilized-microtubule
#9
Avi Ginsburg, Asaf Shemesh, Abigail Millgram, Raviv Dharan, Yael Levi-Kalisman, Israel Ringel, Uri Raviv
Microtubule (MT) is made of αβ-tubulin heterodimers that dynamically assemble into a hollow nanotube composed of straight protofilaments. MT dynamics is facilitated by hydrolysis of guanosine-5'-triphosphate (GTP) and can be inhibited by either anticancer agents like taxol or by the non-hydrolyzable GTP analogues like GMPPCP. Using high-resolution synchrotron X-ray scattering, we have measured and analyzed the scattering curves from solutions of dynamic MT (in other words, in the presence of excess GTP and free of dynamic-inhibiting agents) and examined the effect of two MT stabilizers: taxol and GMPPCP...
August 18, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28820411/-importance-of-shear-wave-elastography-of-livers-in-practically-healthy-pregnant-women
#10
E Sariyeva, S Salahova, N Bayramov
Pulse-wave elastography (SWE) that is one of the mostly used methods in the recent years holds important place in assessment of liver fibrosis. However there is no exact information on the results of liver elastography in healthy pregnant women in the world literature. The aim of the study was to investigate theSWE parameters of liver elastography in practically healthy pregnant women. The subject of the research was 50 practically healthy pregnant women within 18-45 years old (mean age 27.7±0.7). The pregnant women with genital and extragenital diseases were not included to the research...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28819889/visualization-of-57-fe-labeled-heme-isotopic-fine-structure-and-localization-of-regions-of-erythroblast-maturation-in-mouse-spleen-by-maldi-fticr-ms-imaging
#11
Makoto Kihara, Yukari Matsuo-Tezuka, Mariko Noguchi-Sasaki, Keigo Yorozu, Mitsue Kurasawa, Yasushi Shimonaka, Michinori Hirata
Epoetin beta pegol (continuous erythropoiesis receptor activator; C.E.R.A.), or methoxy-polyethylene glycol-modified epoetin beta, is a long-acting erythropoiesis stimulating agent (ESA) that effectively maintains hemoglobin levels. It promotes proliferation of erythroid progenitor cells in hematopoietic organs and leads to increased reticulocyte and hemoglobin levels. However, the detailed erythropoietic effects of various ESAs on their target organs have yet to be clarified, and new approaches are needed to analyze tissue iron localization with structural information...
August 17, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28819781/comparison-of-synthetic-mammography-reconstructed-from-digital-breast-tomosynthesis-and-digital-mammography-evaluation-of-lesion-conspicuity-and-bi-rads-assessment-categories
#12
Giovanna Mariscotti, Manuela Durando, Nehmat Houssami, Mirella Fasciano, Alberto Tagliafico, Davide Bosco, Cristina Casella, Camilla Bogetti, Laura Bergamasco, Paolo Fonio, Giovanni Gandini
PURPOSE: To compare the interpretive performance of synthetic mammography (SM), reconstructed from digital breast tomosynthesis (DBT), and full-field digital mammography (FFDM) in a diagnostic setting, covering different conditions of breast density and mammographic signs. METHODS: A retrospective analysis was conducted on 231 patients, who underwent FFDM and DBT (from which SM images were reconstructed) between September 2014-September 2015. The study included 250 suspicious breast lesions, all biopsy proven: 148 (59...
August 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28819665/efficient-photoelectrochemical-water-splitting-on-ultrasmall-defect-rich-taox-nanoclusters-enhanced-by-size-selected-pt-nanocluster-promoters
#13
Saurabh Srivastava, Joseph Palathinkal Thomas, Nina Heinig, Marwa Abd-Ellah, Md Anisur Rahman, Kam Tong Leung
Formation of nanoclusters has attracted a lot of attention in recent years because of their distinct properties from isolated atoms and bulk solids. Here, we focus on the catalytic properties of supported transition metal oxide nanoclusters, such as TaO2, with a well-defined size distribution below 10 nm. We show that their catalytic performance can be greatly enhanced by introducing a reaction promoter such as Pt. Different combinations of precisely size-selected, defect-rich TaOx and Pt nanoclusters are produced by a gas-phase aggregation technique in a special DC magnetron sputtering system...
August 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28819236/impact-of-sex-fat-distribution-and-initial-body-weight-on-oxytocin-s-body-weight-regulation
#14
Yuko Maejima, Masato Aoyama, Kazuho Sakamoto, Teruo Jojima, Yoshimasa Aso, Katsuya Takasu, Seiichi Takenosihita, Kenju Shimomura
Obesity is considered as a worldwide problem in both males and females. Although many studies have demonstrated the efficiency of oxytocin (Oxt) as an anti-obesity peptide, there is no comparative study of its effect in males and females. This study aims to determine factors (sex, initial body weight, and fat distribution) that may affect the ability of Oxt to regulate body weight (BW). With regard to sex, Oxt reduced BW similarly in males and females under both high fat diet (HFD) and standard chow-fed condition...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819139/landscape-of-submitochondrial-protein-distribution
#15
F-Nora Vögtle, Julia M Burkhart, Humberto Gonczarowska-Jorge, Cansu Kücükköse, Asli Aras Taskin, Dominik Kopczynski, Robert Ahrends, Dirk Mossmann, Albert Sickmann, René P Zahedi, Chris Meisinger
The mitochondrial proteome comprises ~1000 (yeast)-1500 (human) different proteins, which are distributed into four different subcompartments. The sublocalization of these proteins within the organelle in most cases remains poorly defined. Here we describe an integrated approach combining stable isotope labeling, various protein enrichment and extraction strategies and quantitative mass spectrometry to produce a quantitative map of submitochondrial protein distribution in S. cerevisiae. This quantitative landscape enables a proteome-wide classification of 986 proteins into soluble, peripheral, and integral mitochondrial membrane proteins, and the assignment of 818 proteins into the four subcompartments: outer membrane, inner membrane, intermembrane space, or matrix...
August 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28817738/compliance-with-supportive-periodontal-treatment-in-patients-with-dental-implants
#16
Kai-Fang Hu, Ying-Chu Lin, Kun-Yen Ho, Yu-Hsiang Chou
PURPOSE: The need for dental implants is increasing, and supportive periodontal treatment can achieve long-term success and prevent peri-implantitis. Contributing factors to noncompliance with long-term scheduled supportive periodontal treatment remain unclear. To investigate whether demographic and clinical characteristics are associated with noncompliance, the authors analyzed data for patients who had received dental implants. MATERIALS AND METHODS: The authors recruited patients participating in a supportive periodontal treatment program after receiving permanent prostheses on implants placed from 2005 to 2013...
August 17, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28817729/comparison-of-bioimpedance-spectroscopy-and-x-ray-micro-computed-tomography-for-total-fat-volume-measurement-in-mice
#17
Gaelle Aubertin, Amira Sayeh, Jean-Philippe Dillenseger, Estelle Ayme-Dietrich, Philippe Choquet, Nathalie Niederhoffer
Obesity and the metabolic syndrome are two pathologies whose prevalence are in a constant increase. Evaluation of the total fat mass but also of the distribution between visceral and subcutaneous adipose tissue are important factors while assessing the pathophysiology of these two pathologies. Computed tomography (CT) and bioimpedance (BIS) are the translational methods the most frequently used in human beings as well as in rodent models in longitudinal studies on adiposity and obesity. Surprisingly, no direct comparison of micro-CT and BIS was reported yet in mice...
2017: PloS One
https://www.readbyqxmd.com/read/28817606/distribution-and-associations-of-intraocular-pressure-in-7-and-12-year-old-chinese-children-the-anyang-childhood-eye-study
#18
Shuning Li, Shi-Ming Li, Xiao-Lei Wang, Meng-Tian Kang, Luo-Ru Liu, He Li, Shi-Fei Wei, An-Ran Ran, Siyan Zhan, Ravi Thomas, Ningli Wang
PURPOSE: To report the intraocular pressure (IOP) and its association with myopia and other factors in 7 and 12-year-old Chinese children. METHODS: All children participating in the Anyang Childhood Eye Study underwent non-contact tonometry as well as measurement of central corneal thickness (CCT), axial length, cycloplegic auto-refraction, blood pressure, height and weight. A questionnaire was used to collect other relevant information. Univariable and multivariable analysis were performed to determine the associations of IOP...
2017: PloS One
https://www.readbyqxmd.com/read/28817419/the-association-of-fat-and-lean-tissue-with-whole-body-and-spine-bone-mineral-density-is-modified-by-hiv-status-and-sex-in-children-and-youth
#19
Denise L Jacobson, Jane C Lindsey, Brent A Coull, Kathleen Mulligan, Priya Bhagwat, Grace M Aldrovandi
BACKGROUND: HIV-infected (HIV-pos) male children/youth showed lower bone mineral density at sexual maturity than HIV-uninfected (HIV-neg) females. It is not known whether complications of HIV disease, including abnormal body fat distribution, contribute to lower bone accrual in male HIV-pos adolescents. METHODS: In a cross-sectional study, we evaluated the relationship between body composition (fat and lean mass) and bone mass in HIV-pos and HIV-neg children/youth and determined if it is modified by HIV status and sex...
August 16, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28815281/quantitative-characterization-of-colloidal-assembly-of-graphene-oxide-silver-nanoparticle-hybrids-using-aerosol-differential-mobility-coupled-mass-analyses
#20
Thai Phuong Nguyen, Wei-Chang Chang, Yen-Chih Lai, Ta-Chih Hsiao, De-Hao Tsai
In this work, we develop an aerosol-based, time-resolved ion mobility-coupled mass characterization method to investigate colloidal assembly of graphene oxide (GO)-silver nanoparticle (AgNP) hybrid nanostructure on a quantitative basis. Transmission electron microscopy (TEM) and zeta potential (ZP) analysis were used to provide visual information and elemental-based particle size distributions, respectively. Results clearly show a successful controlled assembly of GO-AgNP by electrostatic-directed heterogeneous aggregation between GO and bovine serum albumin (BSA)-functionalized AgNP under an acidic environment...
August 16, 2017: Analytical and Bioanalytical Chemistry
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