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Cardiopulmonary testing and cancer

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https://www.readbyqxmd.com/read/29773446/effects-of-preparatory-coaching-and-home-practice-for-deep-inspiration-breath-hold-on-cardiac-dose-for-left-breast-radiation-therapy
#1
A Kim, A M Kalet, N Cao, D S Hippe, L C Fang, L Young, J Meyer, E V Lang, N A Mayr
AIMS: Deep inspiration breath hold (DIBH) reduces cardiac radiation exposure by creating cardiac-chest wall separation in breast cancer radiotherapy. DIBH requires sustaining chest wall expansion for up to 40 s and involves complex co-ordination of thoraco-abdominal muscles, which may not be intuitive to patients. We investigated the effect of in-advance preparatory DIBH coaching and home practice on cardiac doses. MATERIALS AND METHODS: Successive patients from 1 February 2015 to 31 December 2016 with left-sided breast cancer who underwent tangential field radiotherapy utilising the DIBH technique were included...
May 14, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29764969/cardiovascular-phenotype-and-prognosis-of-patients-with-heart-failure-induced-by-cancer-therapy
#2
Wilson Nadruz, Erin West, Morten Sengeløv, Gabriela L Grove, Mário Santos, John D Groarke, Daniel E Forman, Brian Claggett, Hicham Skali, Anju Nohria, Amil M Shah
OBJECTIVE: This study compared the clinical features, cardiac structure and function evaluated by echocardiography, cardiopulmonary response to exercise and long-term clinical outcomes between patients with heart failure (HF) induced by cancer therapy (CTHF) and heart failure not induced by cancer therapy (NCTHF). METHODS: We evaluated 75 patients with CTHF and 894 with NCTHF who underwent clinically indicated cardiopulmonary exercise testing, and followed these individuals for a median of 4...
May 15, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29741279/testing-physical-function-in-children-undergoing-intense-cancer-treatment-a-respect-feasibility-study
#3
Martin K F Nielsen, Jesper F Christensen, Thomas L Frandsen, Troels Thorsteinsson, Lars B Andersen, Karl B Christensen, Jacob Nersting, Marianne Faber, Kjeld Schmiegelow, Hanne B Larsen
BACKGROUND: The physical function of children with cancer is reduced during treatment, which can compromise the quality of life and increase the risk of chronic medical conditions. The study, "REhabilitation, including Social and Physical activity and Education in Children and Teenagers with cancer" (Clinicaltrials.gov: NCT01772862) examines the efficacy of multimodal rehabilitation strategies introduced at cancer diagnosis. This article addresses the feasibility of and obstacles to testing physical function in children with cancer...
May 9, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29692190/routine-pre-and-post-neoadjuvant-chemotherapy-fitness-testing-is-not-indicated-for-oesophagogastric-cancer-surgery
#4
R J Drummond, D Vass, H Wadhawan, C F Craig, C K MacKay, G M Fullarton, M J Forshaw
Introduction There is a known correlation between anaerobic threshold (AT) during cardiopulmonary exercise testing and development of cardiopulmonary complications in high-risk patients undergoing oesophagogastric cancer surgery. This study aimed to assess the value of routine retesting following neoadjuvant chemotherapy. Methods Patients undergoing neoadjuvant chemotherapy with subsequent oesophagogastric cancer surgery with pre- and post-neoadjuvant chemotherapy cardiopulmonary exercise data were identified from a prospectively maintained database...
April 25, 2018: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29673080/systemic-sclerosis-and-malignancy
#5
Gokhan Sargin, Taskin Senturk, Songul Cildag
BACKGROUND: Systemic sclerosis (SSc) has increased risk of morbidity and mortality due to pulmonary fibrosis, pulmonary arterial hypertension, renal crisis, infections and malignancies. Chemical exposure, smoking and cytotoxic drugs increase the malignancy risk in rheumatic diseases including SSc. We aim to evaluate characteristics, identify risk factors and mortality in SSc patients with malignancies. METHODS: One hundred and fifty-three patients with SSc (24 male, 129 female, with mean age of 56...
April 19, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29621923/laparoscopic-hysterectomy-for-endometrial-cancer-impact-of-age-on-clinical-outcomes
#6
W W Ee, V Nellore, W McMullen, K Ragupathy
INTRODUCTION: Improvement in preoperative care for the ageing population has resulted in an increasing number of elderly patients to be considered for surgery. With an increased incidence of endometrial cancer, it is inevitable that a significant number of elderly patients are referred for surgery, despite the concerns over co-morbid conditions and diminished cardiopulmonary reserves. AIM: To evaluate the clinical outcomes of laparoscopic hysterectomy for elderly women operated on for endometrial cancer with comparison to younger patients...
April 6, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29601082/cardiopulmonary-fitness-before-and-after-neoadjuvant-chemotherapy-in-patients-with-oesophagogastric-cancer
#7
M Navidi, A W Phillips, S M Griffin, K E Duffield, A Greystoke, K Sumpter, R C F Sinclair
BACKGROUND: Neoadjuvant chemotherapy may have a detrimental impact on cardiorespiratory reserve. Determination of oxygen uptake at the anaerobic threshold by cardiopulmonary exercise testing (CPET) provides an objective measure of cardiorespiratory reserve. Anaerobic threshold can be used to predict perioperative risk. A low anaerobic threshold is associated with increased morbidity after oesophagogastrectomy. The aim of this study was to establish whether neoadjuvant chemotherapy has an adverse effect on fitness, and whether there is recovery of fitness before surgery for oesophageal and gastric adenocarcinoma...
March 30, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29581673/changes-in-exercise-tolerance-and-quality-of-life-are-unrelated-in-lung-cancer-survivors-who-undergo-video-assisted-thoracic-surgery
#8
Kunihiko Anami, Jun Horie, Yoshiyasu Hirayama, Naoki Yamashita, Kenichi Ito
[Purpose] The associations between changes in respiratory function, exercise tolerance, and quality of life (QOL) in patients with lung cancer who undergo lobectomy using video-assisted thoracoscopic surgery (VATS) are unclear. This study aimed to investigate the relationships between exercise tolerance and QOL in patients who underwent VATS. [Subjects and Methods] Thirty-six patients with lung cancer were followed for 3 months after VATS. Patients were evaluated before and 1, 4, and 12 weeks after surgery...
March 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29555526/neoadjuvant-therapy-reduces-cardiopulmunary-function-in-patients-undegoing-oesophagectomy
#9
Iain G Thomson, Matthew P Wallen, Adrian Hall, Rebekah Ferris, David C Gotley, Andrew P Barbour, Andrew Lee, Janine Thomas, Bernard M Smithers
Neoadjuvant therapy (NAT) for oesophageal cancer may reduce cardiopulmonary function, assessed by cardiopulmonary exercise testing (CPEX). Impaired cardiopulmonary function is associated with mortality following esophagectomy. We sought to assess the impact of NAT on cardiopulmonary function using CPEX and assessing the clinical relevance of any change in particular if changes were associated with post-operative morbidity. This was a prospective, cohort study of 40 patients in whom CPEX was performed before and after NAT...
March 16, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29550383/liposomal-grb2-antisense-oligodeoxynucleotide-bp1001-in-patients-with-refractory-or-relapsed-haematological-malignancies-a-single-centre-open-label-dose-escalation-phase-1-1b-trial
#10
Maro Ohanian, Ana Tari Ashizawa, Guillermo Garcia-Manero, Naveen Pemmaraju, Tapan Kadia, Elias Jabbour, Farhad Ravandi, Gautam Borthakur, Michael Andreeff, Marina Konopleva, Miranda Lim, Sherry Pierce, Susan O'Brien, Yesid Alvarado, Srdan Verstovsek, William Wierda, Hagop Kantarjian, Jorge Cortes
BACKGROUND: Activating mutations of tyrosine kinases are common in leukaemias. Oncogenic tyrosine kinases use the growth factor receptor-bound protein 2 (Grb2) for signal transduction, leading to activation of mitogen-activated protein kinase (MAPK) 1 and MAPK3 (ERK2 and ERK1). We hypothesised that inhibition of Grb2 would suppress ERK1 and ERK2 activation and inhibit leukaemia progression. To inhibit Grb2, a liposome-incorporated antisense oligodeoxynucleotide that blocks Grb2 protein expression, BP1001, was developed...
April 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29474884/cardiopulmonary-exercise-testing-in-hepato-biliary-pancreas-cancer-surgery-a-systematic-review-are-we-any-further-than-walking-up-a-flight-of-stairs
#11
REVIEW
R Kumar, G Garcea
INTRODUCTION: Cardiopulmonary exercise testing (CPET) is a reliable, reproducible and non-invasive measure of functional capacity. CPET has been increasingly used to assess pre-operative risk and stratify patients at risk of mortality and morbidity following surgery. CPET parameters that predict outcomes within liver and pancreas cancer surgery still remain to be defined. METHODS: A systematic review to assess CPET use in predicting post-operative outcomes in liver and pancreas cancer surgery was carried out using the following databases AMED, CINAHL, Cochrane Library, EMBASE, Google Scholar and PubMED...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29459017/poor-performance-in-incremental-shuttle-walk-and-cardiopulmonary-exercise-testing-predicts-poor-overall-survival-for-patients-undergoing-esophago-gastric-resection
#12
Jessica Whibley, Christopher J Peters, Laura J Halliday, Asif M Chaudry, William H Allum
INTRODUCTION: Esophageal and gastric cancer have a poor prognosis and surgical intervention is associated with considerable morbidity, highlighting the need for careful preoperative assessment. The Incremental Shuttle Walk Test (ISWT) and Cardiopulmonary exercise testing (CPET) can assess preoperative fitness. This study aims to investigate their correlation with both postoperative respiratory complications and overall survival. PATIENTS AND METHODS: Patients were identified who underwent esophageal or gastric resections for cancer between 2010 and 2014 and had ISWT and/or CPET assessments...
May 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29456045/hepatectomy-for-octogenarians-with-colorectal-liver-metastasis-in-the-era-of-enhanced-recovery
#13
Andrea Tufo, Declan F J Dunne, Nichola Manu, Heman Joshi, Carmen Lacasia, Louise Jones, Hassan Z Malik, Graeme J Poston, Stephen W Fenwick
BACKGROUND: Concern exists regarding the use of hepatectomy to treat colorectal liver metastasis (CRLM) in octogenarians due to prior studies suggesting elevated morbidity and mortality. Cardiopulmonary exercise testing (CPET) within pre-operative assessment and enhanced recovery after surgery (ERAS) have both been shown to be associated with low morbidity and mortality in patients undergoing hepatectomy. This study sought to compare the outcomes of octogenarians with patients aged 70-79 undergoing hepatectomy for CRLM, within a center utilizing both CPET and ERAS...
February 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29452805/perioperative-cardiopulmonary-exercise-testing-cpet-consensus-clinical-guidelines-on-indications-organization-conduct-and-physiological-interpretation
#14
D Z H Levett, S Jack, M Swart, J Carlisle, J Wilson, C Snowden, M Riley, G Danjoux, S A Ward, P Older, M P W Grocott
The use of perioperative cardiopulmonary exercise testing (CPET) to evaluate the risk of adverse perioperative events and inform the perioperative management of patients undergoing surgery has increased over the last decade. CPET provides an objective assessment of exercise capacity preoperatively and identifies the causes of exercise limitation. This information may be used to assist clinicians and patients in decisions about the most appropriate surgical and non-surgical management during the perioperative period...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452599/feasibility-and-acceptability-of-pre-operative-physical-activity-to-improve-patient-outcomes-after-major-cancer-surgery-study-protocol-for-a-pilot-randomised-controlled-trial-pepa-trial
#15
Daniel Steffens, Jane Young, Paula R Beckenkamp, James Ratcliffe, Freya Rubie, Nabila Ansari, Neil Pillinger, Michael Solomon
BACKGROUND: There is a need for evidence of the effectiveness of pre-operative exercise for patients undergoing major cancer surgery; however, recruitment to such trials can be challenging. The PrE-operative Physical Activity (PEPA) Trial will establish the feasibility and acceptability of a pre-operative exercise programme aimed to improve patient outcomes after cytoreductive surgery and pelvic exenteration. The secondary aim is to obtain pilot data on the likely difference in key outcomes (post-operative complications, length of hospital stay, post-operative functional capacity and quality of life) to inform the sample size calculation for the substantive randomised clinical trial...
February 17, 2018: Trials
https://www.readbyqxmd.com/read/29408306/thoracic-skeletal-muscle-is-associated-with-adverse-outcomes-after-lobectomy-for-lung-cancer
#16
Florian J Fintelmann, Fabian M Troschel, Julia Mario, Yves R Chretien, Sheila J Knoll, Ashok Muniappan, Henning A Gaissert
BACKGROUND: Assessment of risk associated with lung cancer resection is primarily based on evaluation of cardiopulmonary function and remains imprecise. We investigated the relationship between thoracic muscle and early outcomes after lobectomy. METHODS: Cross-sectional area of skeletal muscle was measured at the level of the fifth thoracic vertebra on computed tomography in 135 consecutive patients before lobectomy for lung cancer. Patients were stratified into low and high muscle groups using the sex-specific muscle median...
May 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29377872/systematic-review-and-meta-analysis-of-objective-assessment-of-physical-fitness-in-patients-undergoing-colorectal-cancer-surgery
#17
Chun Hin Angus Lee, Joseph C Kong, Hilmy Ismail, Bernhard Riedel, Alexander Heriot
BACKGROUND: Gas exchange-derived variables obtained from cardiopulmonary exercise testing allow objective assessment of functional capacity and hence physiological reserve to withstand the stressors of major surgery. Field walk tests provide an alternate means for objective assessment of functional capacity that may be cheaper and have greater acceptability, in particular, in elderly patients. OBJECTIVE: This systematic review evaluated the predictive value of cardiopulmonary exercise testing and field walk tests in surgical outcomes after colorectal surgery...
March 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29356733/cardiopulmonary-aerobic-fitness-assessment-during-maximal-and-submaximal-exercise-testing-in-pediatric-oncology-patients-after-chemotherapy
#18
Adam W Powell, Rajaram Nagarajan, Wayne A Mays, Clifford Chin, Timothy K Knilans, Sandra K Knecht, Michelle A Amos, Yvette M Gerdes, Thomas D Ryan
PURPOSE: The cardiopulmonary exercise test (CPET) is a valuable tool to assess cardiopulmonary exercise capacity in pediatric oncology patients after chemotherapy. In addition, few studies on the utility of submaximal testing have been performed, which could be important as some patients are unable to complete a maximal effort test secondary to deconditioning by both disease and treatment. MATERIALS AND METHODS: We performed a retrospective chart review of pediatric cancer patients exposed to chemotherapy from 1992 to 2013 who underwent CPET with cycle ergometry (n=27)...
January 19, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29349536/oxygen-uptake-efficiency-slope-and-prediction-of-post-operative-morbidity-and-mortality-in-patients-with-lung-cancer
#19
Sertaç Yakal, Sevtün Sofyalı, Berker Özkan, Safinaz Yıldız, Alper Toker, Erdem Kasikcioglu
OBJECTIVE: Peak oxygen consumption is a very valuable cardiopulmonary functional parameter in pre-operative evaluation of patients with lung cancer. However, it has several critical limitations for operability decision due to failure in achieving maximal level of exercise test for cases. The aim of this study was to reveal the importance of more accurate cardiopulmonary parameters that can be calculated from data of submaximal level test, such as oxygen uptake efficiency slope (OUES) and to determine whether it could be used in the operability decision phase for borderline cases by means of morbidity and mortality...
April 2018: Lung
https://www.readbyqxmd.com/read/29181804/vigorous-intensity-aerobic-interval-exercise-in-bladder-cancer-patients-prior-to-radical-cystectomy-a-feasibility-randomised-controlled-trial
#20
Srijit Banerjee, Kate Manley, Barnabas Shaw, Liane Lewis, Gabriel Cucato, Robert Mills, Mark Rochester, Allan Clark, John M Saxton
PURPOSE: Strategies to improve pre-operative cardiopulmonary fitness could positively impact recovery after surgery. This study investigated the feasibility of vigorous intensity aerobic interval exercise in bladder cancer patients prior to radical cystectomy (RC). METHODS: A total of 60 patients were randomised (1:1) to exercise or control following a cardiopulmonary exercise test (CPET). The exercise group was offered twice-weekly pre-operative supervised vigorous intensity aerobic interval exercise in addition to standard treatment...
November 27, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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