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Cardiopulmonary testing and cancer

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https://www.readbyqxmd.com/read/27771425/short-term-preoperative-high-intensity-interval-training-in-patients-awaiting-lung-cancer-surgery-a-randomized-controlled-trial
#1
Marc Licker, Wolfram Karenovics, John Diaper, Isabelle Frésard, Frédéric Triponez, Christoph Ellenberger, Raoul Schorer, Bengt Kayser, Pierre-Olivier Bridevaux
BACKGROUND: Impairment in aerobic fitness is a potential modifiable risk factor for postoperative complications. In this randomized controlled trial, we hypothesized that a high-intensity interval training (HIIT) program enhances cardiorespiratory fitness before lung cancer surgery and therefore reduces the risk of postoperative complications. METHODS: Patients with operable lung cancer were randomly assigned to usual care (UC, N=77) or preoperative rehabilitation based on HIIT (Rehab, N=74)...
October 5, 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27748503/neuromuscular-electrical-stimulation-for-muscle-weakness-in-adults-with-advanced-disease
#2
REVIEW
Sarah Jones, William D-C Man, Wei Gao, Irene J Higginson, Andrew Wilcock, Matthew Maddocks
BACKGROUND: This review is an update of a previously published review in the Cochrane Database of Systematic Reviews Issue 1, 2013 on Neuromuscular electrical stimulation for muscle weakness in adults with advanced disease.Patients with advanced progressive disease often experience muscle weakness, which can impact adversely on their ability to be independent and their quality of life. In those patients who are unable or unwilling to undertake whole-body exercise, neuromuscular electrical stimulation (NMES) may be an alternative treatment to enhance lower limb muscle strength...
October 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27730011/risk-stratification-in-lung-resection
#3
Michele Salati, Alessandro Brunelli
PURPOSE OF REVIEW: Surgery is considered the best treatment option for patients with early stage lung cancer. Nevertheless, lung resection may cause a variable functional impairment that could influence the whole cardio-respiratory system with potential life-threatening complications. The aim of the present study is to review the most relevant evidences about the evaluation of surgical risk before lung resection, in order to define a practical approach for the preoperative functional assessment in lung cancer patients...
2016: Current Surgery Reports
https://www.readbyqxmd.com/read/27630455/complications-and-benefits-of-intrahospital-transport-of-adult-intensive-care-unit-patients
#4
M M Harish, S Janarthanan, Suhail Sarwar Siddiqui, Harish K Chaudhary, Natesh R Prabu, Jigeeshu V Divatia, Atul Prabhakar Kulkarni
BACKGROUND: The transport of critically ill patients for procedures or tests outside the Intensive Care Unit (ICU) is potentially hazardous; hence, the transport process must be organized and efficient. Plenty of data is available on pre- and inter-hospital transport of patients; the data on intrahospital transport of patients are limited. We audited the complications and benefits of intrahospital transport of critically ill patients in our tertiary care center over 6 months. MATERIALS AND METHODS: One hundred and twenty adult critically ill cancer patients transported from the ICU for either diagnostic or therapeutic procedure over 6 months were included...
August 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27589870/the-effect-of-neoadjuvant-chemotherapy-and-chemoradiotherapy-on-exercise-capacity-and-outcome-following-upper-gastrointestinal-cancer-surgery-an-observational-cohort-study
#5
M A West, L Loughney, G Ambler, B D Dimitrov, J J Kelly, M G Mythen, R Sturgess, P M A Calverley, A Kendrick, M P W Grocott, S Jack
BACKGROUND: In 2014 approximately 21,200 patients were diagnosed with oesophageal and gastric cancer in England and Wales, of whom 37 % underwent planned curative treatments. Potentially curative surgical resection is associated with significant morbidity and mortality. For operable locally advanced disease, neoadjuvant chemotherapy (NAC) improves survival over surgery alone. However, NAC carries the risk of toxicity and is associated with a decrease in physical fitness, which may in turn influence subsequent clinical outcome...
September 2, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27586675/the-association-between-end-of-life-care-and-the-time-interval-between-provision-of-a-do-not-resuscitate-consent-and-death-in-cancer-patients-in-korea
#6
Sun Kyung Baek, Hye Jung Chang, Ja Min Byun, Jae Joon Han, Dae Seog Heo
Purpose: We explored the relationship between the use of each medical intervention and the length of time between DNR consent and death in Korea. Materials and Methods: A total of 295 terminal cancer patients participated in this retrospective study. Invasive interventions [e.g., cardiopulmonary resuscitation (CPR), intubation, and hemodialysis], less invasive interventions (e.g., transfusion, antibiotic use, inotropic use and laboratory tests), and the time interval between the DNR order and death were evaluated...
September 1, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27558253/novel-applications-of-proton-therapy-in-breast-carcinoma
#7
John J Cuaron1, Shannon M MacDonald, Oren Cahlon
This review will focus on the indications, clinical experience, and technical considerations of proton beam radiation therapy in the treatment of patients with breast cancer. For patients with early stage disease, proton therapy delivers less dose to non-target breast tissue for patients receiving partial breast irradiation (PBI) therapy, which may result in improved cosmesis but requires further investigation. For patients with locally advanced breast cancer requiring treatment to the regional lymph nodes, proton therapy allows for an improved dosimetric profile compared with conventional photon and electron techniques...
August 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27535566/massarray-pyrosequencing-and-pna-clamping-for-egfr-mutation-detection-in-lung-cancer-tissue-and-cytological-samples-a-multicenter-study
#8
Kyueng-Whan Min, Wan-Seop Kim, Se Jin Jang, Yoo Duk Choi, Sunhee Chang, Soon Hee Jung, Lucia Kim, Mee-Sook Roh, Choong Sik Lee, Jung Weon Shim, Mi Jin Kim, Geon Kook Lee
BACKGROUND: Testing for epidermal growth factor receptor (EGFR) mutation is an important process in the therapeutic plan of patients with lung cancer. Recently, MassARRAY, based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, has been shown to be a useful method for somatic mutation analysis with pyrosequencing and peptide nucleic acid clamping (PNAc). METHODS: A total of 107 tissues and 67 cytological samples, which were confirmed to have lung adenocarcinoma at nine hospitals in Korea, were collected...
October 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27496651/anatomical-segmentectomy-and-wedge-resections-are-associated-with-comparable-outcomes-for-patients-with-small-ct1n0-non-small-cell-lung-cancer
#9
Nasser K Altorki, Mohamed K Kamel, Navneet Narula, Galal Ghaly, Abu Nasar, Mohamed Rahouma, Paul C Lee, Jeffery L Port, Brendon M Stiles
OBJECTIVES: Sublobar resection is advocated for patients with NSCLC and compromised cardiopulmonary reserve, and for selected patients with early stage disease. Anatomic segmentectomy (AS) has traditionally been considered superior to wedge resection (WR), but well-balanced comparative studies are lacking. We hypothesize that WR and AS are associated with comparable oncologic outcomes for patients with cT1N0 NSCLC. METHODS: A retrospective review of a prospective database was performed (2000-2014) for cT1N0 patients, excluding patients with multiple primary tumors, carcinoid tumors, adenocarcinoma in situ, and minimally invasive adenocarcinoma...
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27377407/lifestyle-in-multiple-myeloma-a-longitudinal-cohort-study-protocol
#10
M Heinrich, A Fisher, B Paton, O McCourt, R J Beeken, A Hackshaw, J Wardle, K Yong
BACKGROUND: Deterioration in bone health is one of the presenting symptoms of Multiple Myeloma (MM), a cancer of plasma cells. As a consequence of this condition, patients suffer bone pain and bone damage and report cancer-related fatigue, resulting in deterioration in their quality of life. Evidence in patients with solid tumours shows promise for the positive effects of physical activity on quality of life. However, in the case of patients with MM a better understanding of the association between physical fitness and quality of life factors is still required...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27351215/cardiorespiratory-fitness-in-long-term-lymphoma-survivors-after-high-dose-chemotherapy-with-autologous-stem-cell-transplantation
#11
Jo S Stenehjem, Knut B Smeland, Klaus Murbraech, Harald Holte, Stein Kvaløy, Lene Thorsen, Ingerid Arbo, Lee W Jones, Svend Aakhus, May Brit Lund, Cecilie E Kiserud
BACKGROUND: Cardiorespiratory fitness as measured by peak oxygen consumption (VO2peak) is a strong predictor of longevity and may be compromised by anticancer therapy, inactivity, and smoking. We compared VO2peak among lymphoma survivors (LSs) with reference data from healthy sedentary subjects, after a 10.2-year (mean) follow-up post high-dose chemotherapy with autologous stem cell transplantation (HDT-ASCT). We further examined the association between VO2peak and treatment, physical activity, smoking, pulmonary, and cardiac function...
July 12, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27197920/benefits-of-robotic-cystectomy-with-intracorporeal-diversion-for-patients-with-low-cardiorespiratory-fitness-a-prospective-cohort-study
#12
Benjamin Wilfrid Lamb, Wei Shen Tan, Philip Eneje, David Bruce, Amy Jones, Imran Ahmad, Ashwin Sridhar, Hilary Baker, Tim P Briggs, John E Hines, Senthil Nathan, Daniel Martin, Robert C Stephens, John D Kelly
BACKGROUND: Patients undergoing radical cystectomy have associated comorbidities resulting in reduced cardiorespiratory fitness. Preoperative cardiopulmonary exercise testing (CPET) measures including anaerobic threshold (AT) can predict major adverse events (MAE) and hospital length of stay (LOS) for patients undergoing open and robotic cystectomy with extracorporeal diversion. Our objective was to determine the relationship between CPET measures and outcome in patients undergoing robotic radical cystectomy and intracorporeal diversion (intracorporeal robotic assisted radical cystectomy [iRARC])...
September 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27187100/fitness-during-breast-cancer-treatment-and-recovery-in-an-athlete-a-case-study
#13
Patrick D Savage, Kim Dittus, Susan G Lakoski
PURPOSE: This is a case study of an aerobically trained, multisport, female athlete (age = 39) diagnosed with stage IIIc human epidermal growth factor receptor 2 positive breast cancer. The focus of the study is on measures of cardiorespiratory fitness (V˙O2peak) through the course of cancer therapy. METHODS: A symptom-limited cardiopulmonary exercise tolerance test was performed to determine V˙O2peak. The tests were performed at five different time points: 1) at diagnosis of breast cancer and before initiating chemotherapy, 2) after completion of chemotherapy (5 months postdiagnosis), 3) 2...
October 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27174883/risk-factors-for-short-term-outcomes-after-thoracoscopic-lobectomy-for-lung-cancer
#14
Masataka Irie, Ryoichi Nakanishi, Manabu Yasuda, Yoshihisa Fujino, Kazumi Hamada, Masahiro Hyodo
Few studies have analysed postoperative risk factors in patients undergoing thoracoscopic lobectomy, including assessments of preoperative physical function. The objectives of this study were to identify predictors of postoperative deterioration of performance status and cardiopulmonary complications in cases of thoracoscopic lobectomy.Between June 2005 and October 2012, we retrospectively reviewed 188 consecutive subjects who underwent thoracoscopic lobectomy for preoperative stage I nonsmall cell lung cancer...
August 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/27174411/surgical-risk-evaluation-of-lung-cancer-in-copd-patients-a-cohort-observational-study
#15
F Rodrigues, M Grafino, I Faria, J Pontes da Mata, A L Papoila, F Félix
Coexistence between pulmonary cancer and chronic obstructive pulmonary disease (COPD) is frequent and is anticipated to be lead to high worldwide mortality in the next decades. The most powerful therapeutic approach for non-small cell lung carcinoma is lung surgical resection. However, in COPD patients, this approach bears a higher mortality and morbidity risk, thus requiring an accurate pre-operatory evaluation of the surgical risk comprising a clinical and functional assessment at rest, as well as a cardiopulmonary exercise test...
September 2016: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/27165422/preoperative-peak-oxygen-uptake-in-lung-cancer-subjects-with-neoadjuvant-chemotherapy-a-cross-sectional-study
#16
Isabelle Fresard, Marc Licker, Dan Adler, Alban Lovis, John Robert, Wolfram Karenovics, John Diaper, Jean-Paul Janssens, Frederic Triponez, Frederic Lador, Thierry Rochat, Vicente Espinosa, Chetna Bhatia, Bengt Kayser, Pierre-Olivier Bridevaux
BACKGROUND: In non-small-cell lung cancer patients, high peak oxygen uptake (peak V̇O2 ) predicts lower rates of postoperative complications and better long-term survival. Neoadjuvant chemotherapy (NAC) may negatively impact peak V̇O2 . METHODS: Cardiopulmonary exercise testing (CPET) was performed in 34 consecutive stage IIIA/IIIB non-small-cell lung cancer subjects scheduled for elective lung surgery. Using multivariate linear regression adjusted for potential confounders, we compared CPET results in subjects receiving or not receiving NAC (NAC+, n = 19; NAC-, n = 15)...
August 2016: Respiratory Care
https://www.readbyqxmd.com/read/27156441/the-utility-of-exercise-testing-in-patients-with-lung-cancer
#17
REVIEW
Duc Ha, Peter J Mazzone, Andrew L Ries, Atul Malhotra, Mark Fuster
The harm associated with lung cancer treatment include perioperative morbidity and mortality and therapy-induced toxicities in various organs, including the heart and lungs. Optimal treatment therefore entails a need for risk assessment to weigh the probabilities of benefits versus harm. Exercise testing offers an opportunity to evaluate a patient's physical fitness/exercise capacity objectively. In lung cancer, it is most often used to risk-stratify patients undergoing evaluation for lung cancer resection...
September 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27153557/targeted-photo-chemo-therapy-of-malignancy-on-the-chest-wall-while-cardiopulmonary-avoidance-based-on-fe3o4-zno-nanocomposites
#18
Haijun Zhang, Liting Guo, Shuang Ding, Jian Xiong, Baoan Chen
Treatment of malignancies on the chest wall, like chest wall recurrence of tumor, advanced cutaneous neoplasm and lymphoma, is still a challenge due to the involvement of the critical structures of heart and lung by the conventional strategy. The aim of the current study was to investigate targeted photo-chemo therapy mediated by Fe3O4@ZnO nanocomposites for malignancy on the chest wall while cardiopulmonary avoidance. Fe3O4@ZnO/Dox nanocomposites, the synthesis of the core-shell Fe3O4@ZnO nanocomposites followed by loading doxorubicin (Dox), were prepared to act as multifunctional drug delivery system (DDS)...
June 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/27059429/risk-of-postoperative-complications-in-chronic-obstructive-lung-diseases-patients-considered-fit-for-lung-cancer-surgery-beyond-oxygen-consumption
#19
Hanaa Shafiek, Jose Luis Valera, Bernat Togores, Juan Antonio Torrecilla, Jaume Sauleda, Borja G Cosío
OBJECTIVES: Patients with poor lung function usually undergo cardiopulmonary exercise testing (CPET) and those with a predicted postoperative maximal oxygen consumption (VO2 max) of >10 ml/kg/min undergo lung resection surgery and still some complications are observed. We aimed to determine other parameters beyond VO2 able to predict postoperative complications in patients undergoing lung resection surgery. METHODS: This is an observational study with longitudinal follow-up...
October 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27038515/impaired-right-ventricular-function-in-long-term-lymphoma-survivors
#20
Klaus Murbraech, Espen Holte, Kaspar Broch, Knut B Smeland, Harald Holte, Assami Rösner, May Brit Lund, Håvard Dalen, Cecilie Kiserud, Svend Aakhus
BACKGROUND: Cardiotoxicity from anthracyclines or cardiac radiation therapy is detrimental to left ventricular (LV) function. However, the long-term effects on right ventricular (RV) performance are largely unknown. The aim of this study was to investigate the long-term impact of cardiotoxic treatment on RV function among adult cancer survivors. METHODS: Adult lymphoma survivors (LSs) who underwent autologous hematopoietic stem cell transplantation in Norway from 1987 to 2008 were invited to undergo cardiovascular evaluation by echocardiography and cardiopulmonary exercise testing...
June 2016: Journal of the American Society of Echocardiography
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