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Cancer and exercise

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https://www.readbyqxmd.com/read/29456045/hepatectomy-for-octogenarians-with-colorectal-liver-metastasis-in-the-era-of-enhanced-recovery
#1
Andrea Tufo, Declan F J Dunne, Nichola Manu, Heman Joshi, Carmen Lacasia, Louise Jones, Hassan Z Malik, Graeme J Poston, Stephen W Fenwick
BACKGROUND: Concern exists regarding the use of hepatectomy to treat colorectal liver metastasis (CRLM) in octogenarians due to prior studies suggesting elevated morbidity and mortality. Cardiopulmonary exercise testing (CPET) within pre-operative assessment and enhanced recovery after surgery (ERAS) have both been shown to be associated with low morbidity and mortality in patients undergoing hepatectomy. This study sought to compare the outcomes of octogenarians with patients aged 70-79 undergoing hepatectomy for CRLM, within a center utilizing both CPET and ERAS...
February 6, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29455302/patient-experiences-of-a-physiotherapy-led-multidisciplinary-rehabilitative-intervention-after-successful-treatment-for-oesophago-gastric-cancer
#2
A E Bennett, L O'Neill, D Connolly, E M Guinan, L Boland, S L Doyle, J O'Sullivan, J V Reynolds, J Hussey
PURPOSE: To qualitatively explore the perceived impact of a 12-week rehabilitative intervention for oesophago-gastric cancer survivors on their physical, mental and social wellbeing. METHODS: Of the 21 participants who completed the intervention, 19 took part in a semi-structured focus group interview. Four audio-taped focus groups were held, ranging in size from two to eight participants. Focus groups were transcribed and analysed using a descriptive qualitative approach...
February 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29452805/perioperative-cardiopulmonary-exercise-testing-cpet-consensus-clinical-guidelines-on-indications-organization-conduct-and-physiological-interpretation
#3
D Z H Levett, S Jack, M Swart, J Carlisle, J Wilson, C Snowden, M Riley, G Danjoux, S A Ward, P Older, M P W Grocott
The use of perioperative cardiopulmonary exercise testing (CPET) to evaluate the risk of adverse perioperative events and inform the perioperative management of patients undergoing surgery has increased over the last decade. CPET provides an objective assessment of exercise capacity preoperatively and identifies the causes of exercise limitation. This information may be used to assist clinicians and patients in decisions about the most appropriate surgical and non-surgical management during the perioperative period...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452599/feasibility-and-acceptability-of-pre-operative-physical-activity-to-improve-patient-outcomes-after-major-cancer-surgery-study-protocol-for-a-pilot-randomised-controlled-trial-pepa-trial
#4
Daniel Steffens, Jane Young, Paula R Beckenkamp, James Ratcliffe, Freya Rubie, Nabila Ansari, Neil Pillinger, Michael Solomon
BACKGROUND: There is a need for evidence of the effectiveness of pre-operative exercise for patients undergoing major cancer surgery; however, recruitment to such trials can be challenging. The PrE-operative Physical Activity (PEPA) Trial will establish the feasibility and acceptability of a pre-operative exercise programme aimed to improve patient outcomes after cytoreductive surgery and pelvic exenteration. The secondary aim is to obtain pilot data on the likely difference in key outcomes (post-operative complications, length of hospital stay, post-operative functional capacity and quality of life) to inform the sample size calculation for the substantive randomised clinical trial...
February 17, 2018: Trials
https://www.readbyqxmd.com/read/29451666/pilates-for-breast-cancer-a-systematic-review-and-meta-analysis
#5
Roberta Costa Espíndula, Gabriella Barbosa Nadas, Maria Inês da Rosa, Charlie Foster, Florentino Cardoso de Araújo, Antonio Jose Grande
INTRODUCTION: Breast cancer is the leading type of cancer causing death in women worldwide. The incidence of the disease is expected to grow worldwide due to the aging of the population and risk factors related to lifestyle behaviors. Considering the lifestyle of women with breast cancer before or after surgery, pilates exercise may be a complementary intervention additionally to standard treatment. OBJECTIVE: To analyze the efficacy of pilates compared to other exercises and to no exercise for women with breast cancer diagnosis...
November 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29451333/urban-rural-differences-in-aerobic-physical-activity-muscle-strengthening-exercise-and-screen-time-sedentary-behavior
#6
Michael C Robertson, Jaejoon Song, Wendell C Taylor, Casey P Durand, Karen M Basen-Engquist
PURPOSE: Compared to their urban counterparts, US residents in rural settings face an increased risk of premature mortality and health problems that have been linked to insufficient physical activity (PA) levels. There is limited literature regarding urban-rural differences in adherence to national guidelines for all 3 PA-related behaviors. METHODS: We investigated urban-rural differences in aerobic PA, leisure-time muscle strengthening PA, and leisure screen-time sedentary behavior in a combined data set of the 2011-2014 waves (N = 14,188) of the nationally representative National Cancer Institute's Health Information National Trends Survey...
February 16, 2018: Journal of Rural Health
https://www.readbyqxmd.com/read/29445858/l-thyroxine-intake-as-a-potential-risk-factor-for-the-development-of-fatigue-in-breast-cancer-patients-undergoing-chemotherapy
#7
Martina E Schmidt, Joachim Wiskemann, Theron Johnson, Nina Habermann, Andreas Schneeweiss, Karen Steindorf
PURPOSE: L-Thyroxine is one of the most commonly prescribed drugs and accordingly used by many breast cancer patients with thyroid disorders. Hence, potential interactions of chemotherapy with L-thyroxine, possibly contributing to fatigue, would be of high clinical relevance. Therefore, we investigated fatigue and underlying pathways in L-thyroxine-using breast cancer patients during chemotherapy. METHODS: Thyroid-stimulating hormone (TSH), L-triiodothyronine (T3), and diurnal salivary cortisol patterns were analyzed in breast cancer patients in the beginning and at the end of adjuvant chemotherapy within the control group (n = 41) of a randomized exercise intervention trial...
February 14, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29445285/the-effect-of-exercise-on-cancer-related-fatigue-in-cancer-survivors-a-systematic-review-and-meta-analysis
#8
REVIEW
Ellen Kessels, Olga Husson, Christina M van der Feltz-Cornelis
Objective: The objective of the study was to conduct systematic review and meta-analysis to establish the effect of exercise interventions on cancer-related fatigue (CRF) in cancer survivors, compared to non-exercise intervention controls. Methods: Trials published between January 1st 2000 and August 17th 2016 were included through PubMed database search and search of references. Eligible trials compared the effect of an exercise intervention on CRF compared to non-exercise intervention controls, with CRF as primary outcome and measured by validated self-report questionnaire, in cancer survivors not receiving palliative care...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29443878/skeletal-muscle-pathophysiology-the-emerging-role-of-spermine-oxidase-and-spermidine
#9
REVIEW
Manuela Cervelli, Alessia Leonetti, Guglielmo Duranti, Stefania Sabatini, Roberta Ceci, Paolo Mariottini
Skeletal muscle comprises approximately 40% of the total body mass. Preserving muscle health and function is essential for the entire body in order to counteract chronic diseases such as type II diabetes, cardiovascular diseases, and cancer. Prolonged physical inactivity, particularly among the elderly, causes muscle atrophy, a pathological state with adverse outcomes such as poor quality of life, physical disability, and high mortality. In murine skeletal muscle C2C12 cells, increased expression of the spermine oxidase (SMOX) enzyme has been found during cell differentiation...
February 14, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29440214/-it-has-saved-thousands-of-lives-so-why-change-it-content-analysis-of-objections-to-cervical-screening-programme-changes-in-australia
#10
Helena M Obermair, Rachael H Dodd, Carissa Bonner, Jesse Jansen, Kirsten McCaffery
OBJECTIVES: The incidence and mortality of cervical cancer have halved since introduction of the Australian cervical screening programme in 1991, involving 2-yearly Pap smears from ages 18-69 years. In 2017, the programme changed to 5- yearly primary human papillomavirus (HPV) testing for women aged 25-74 years. This study investigated reasons for opposition to the renewed screening programme within the open-ended comments of an online petition, 'Stop May 1st Changes to Pap Smears-Save Women's Lives', opposing the changes, which received over 70 000 signatures and almost 20 000 comments...
February 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29440149/cancer-cachexia-rationale-for-the-menac-multimodal-exercise-nutrition-and-anti-inflammatory-medication-for-cachexia-trial
#11
REVIEW
Tora S Solheim, Barry J A Laird, Trude R Balstad, Asta Bye, Guro Stene, Vickie Baracos, Florian Strasser, Gareth Griffiths, Matthew Maddocks, Marie Fallon, Stein Kaasa, Kenneth Fearon
Cancer cachexia is a multifactorial syndrome characterised by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support alone. Cachexia has a high prevalence in cancer and a major impact on patient physical function, morbidity and mortality. Despite the consequences of cachexia, there is no licensed treatment for cachexia and no accepted standard of care. It has been argued that the multifactorial genesis of cachexia lends itself to therapeutic targeting through a multimodal treatment...
February 9, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29437202/lymphedema-in-ovarian-cancer-survivors-assessing-diagnostic-methods-and-the-effects-of-physical-activity
#12
Neel S Iyer, Brenda Cartmel, Louis Friedman, Fangyong Li, Yang Zhou, Elizabeth Ercolano, Maura Harrigan, Linda Gottlieb, Ruth McCorkle, Peter E Schwartz, Melinda L Irwin
BACKGROUND: Lymphedema is a poorly understood side effect of gynecologic cancer treatment. This study was designed to determine the prevalence of lower limb lymphedema (LLL) in a sample of ovarian cancer survivors via 3 different diagnostic methods and to assess the effect of a randomized exercise intervention. METHODS: Physically inactive ovarian cancer survivors (n = 95) were enrolled in a 6-month randomized trial of exercise (primarily brisk walking) versus attention control...
February 13, 2018: Cancer
https://www.readbyqxmd.com/read/29437041/preoperative-exercise-halves-the-postoperative-complication-rate-in-patients-with-lung-cancer-a-systematic-review-of-the-effect-of-exercise-on-complications-length-of-stay-and-quality-of-life-in-patients-with-cancer
#13
REVIEW
Daniel Steffens, Paula R Beckenkamp, Mark Hancock, Michael Solomon, Jane Young
OBJECTIVE: To investigate the effectiveness of preoperative exercises interventions in patients undergoing oncological surgery, on postoperative complications, length of hospital stay and quality of life. DESIGN: Intervention systematic review with meta-analysis. DATA SOURCES: MEDLINE, Embase and PEDro. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Trials investigating the effectiveness of preoperative exercise for any oncological patient undergoing surgery were included...
February 1, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29435448/toward-a-tiered-model-to-share-clinical-trial-data-and-samples-in-precision-oncology
#14
Stefanie Broes, Denis Lacombe, Michiel Verlinden, Isabelle Huys
The recent revolution in science and technology applied to medical research has left in its wake a trial of biomedical data and human samples; however, its opportunities remain largely unfulfilled due to a number of legal, ethical, financial, strategic, and technical barriers. Precision oncology has been at the vanguard to leverage this potential of "Big data" and samples into meaningful solutions for patients, considering the need for new drug development approaches in this area (due to high costs, late-stage failures, and the molecular diversity of cancer)...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29433474/real-life-feasibility-of-home-based-pulmonary-rehabilitation-in-chemotherapy-treated-patients-with-thoracic-cancers-a-pilot-study
#15
Cecile Olivier, Jean-Marie Grosbois, Alexis B Cortot, Sophie Peres, Christophe Heron, Julie Delourme, Marianne Gierczynski, Anne Hoorelbeke, Arnaud Scherpereel, Olivier Le Rouzic
BACKGROUND: Patients with advanced lung cancer (LC) or malignant pleural mesothelioma (MPM) exhibit limitation of exercise capacities and alteration of quality of life (QoL) induced by cancer and its treatment. Few studies assessed pulmonary rehabilitation (PR) in these chemotherapy-treated patients, and none evaluated a home-based PR program. METHODS: In this prospective uncontrolled observational pilot study, patients treated by chemotherapy for LC or MPM were screened for a home-based PR program combining exercise training with global cares including therapeutic education and psychosocial management...
February 13, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29432357/perspectives-of-oncology-nurses-on-complementary-and-alternative-medicine-in-turkey-a-cross-sectional-survey
#16
Zehra Gok Metin, Nur Izgu, Canan Karadas, Ayse Arikan Donmez
In Turkey, between 22.1% and 84.1% of patients with cancer use complementary and alternative medicine (CAM). However, few CAM-related studies have focused on the perspective of oncology nurses. This study aimed to determine the knowledge, attitudes, and practices of Turkish oncology nurses regarding CAM. A descriptive cross-sectional survey of 127 participants was conducted in Ankara, Turkey. A semistructured questionnaire including characteristics, knowledge, attitudes, and practices of oncology nurses toward CAM was administered to participants...
March 2018: Holistic Nursing Practice
https://www.readbyqxmd.com/read/29429006/exercise-capacity-and-cancer-specific-quality-of-life-following-curative-intent-treatment-of-stage-i-iiia-lung-cancer
#17
Duc Ha, Andrew L Ries, Peter J Mazzone, Scott M Lippman, Mark M Fuster
PURPOSE: Lung cancer survivors are at risk for health impairments resulting from the effects and/or treatment of lung cancer and comorbidities. Practical exercise capacity (EC) assessments can help identify impairments that would otherwise remain undetected. In this study, we characterized and analyzed the association between functional EC and cancer-specific quality of life (QoL) in lung cancer survivors who previously completed curative intent treatment. METHODS: In a cross-sectional study of 62 lung cancer survivors who completed treatment ≥ 1 month previously, we assessed functional EC with the 6-min walk distance (6MWD) and cancer-specific QoL with the European Organization for Research and Treatment of Cancer QoL Questionnaire Core 30 (EORTC-QLQ-C30)...
February 10, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29428830/the-effect-of-a-randomized-controlled-physical-activity-trial-on-health-related-quality-of-life-in-metabolically-unhealthy-african-american-women
#18
Teletia Taylor, Chiranjeev Dash, Kepher Makambi, Xiaoyang Ma, Vanessa Sheppard, Lucile L Adams-Campbell
PURPOSE: African-American women have a higher incidence and mortality from breast cancer compared to most other racial/ethnic groups. African-American women are also more likely to be metabolically unhealthy than White women. Several studies have suggested that metabolic syndrome affects health-related quality of life (HRQoL). Despite numerous exercise studies reporting improvements in metabolic syndrome, no study to date has examined the effect of exercise on HRQoL in metabolically unhealthy African-American women...
February 8, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29428078/a-case-oriented-web-based-training-system-for-breast-cancer-diagnosis
#19
Qinghua Huang, Xianhai Huang, Longzhong Liu, Yidi Lin, Xingzhang Long, Xuelong Li
BACKGROUND AND OBJECTIVE: Breast cancer is still considered as the most common form of cancer as well as the leading causes of cancer deaths among women all over the world. We aim to provide a web-based breast ultrasound database for online training inexperienced radiologists and giving computer-assisted diagnostic information for detection and classification of the breast tumor. METHODS: We introduce a web database which stores breast ultrasound images from breast cancer patients as well as their diagnostic information...
March 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29426388/goal-attainment-and-goal-adjustment-of-older-adults-during-person-directed-cancer-rehabilitation
#20
Kathleen Doyle Lyons, Robin M Newman, Peter A Kaufman, Martha L Bruce, Diane M Stearns, Frederick Lansigan, Mary Chamberlin, Stephen J Bartels, Jessica Whipple, Mark T Hegel
OBJECTIVE: In this pilot study of a home-based occupational therapy intervention intended to reduce disability and improve quality of life, our objective was to identify rates of goal attainment and patterns of goal adjustment of participants. METHOD: Thirty older adults with cancer were randomized to the intervention arm, and 24 participants identified goals and completed the six-session intervention. An exploratory content analysis of qualitative and quantitative session data was performed...
March 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
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