keyword
https://read.qxmd.com/read/38348200/burkitt-lymphoma-with-aberrant-expression-of-cytoplasmic-terminal-deoxynucleotidyl-transferase-a-case-report
#21
Mark T Cunningham, Carmen Winters, Daniel Farrell
This study describes a rare case of Burkitt lymphoma with aberrant expression of cytoplasmic terminal deoxynucleotidyl transferase (TdT). Flow cytometry demonstrated a predominantly mature B cell immunophenotype as expected for Burkitt lymphoma, however, the immature marker TdT was also expressed. Immunohistochemistry showed that TdT was localized to the cytoplasm, with absent nuclear localization. The patient received standard intensive chemotherapy for Burkitt lymphoma and has remained in remission for nine years...
February 2024: Curēus
https://read.qxmd.com/read/38339976/the-treatment-of-burkitt-lymphoma-with-the-berlin-frankfurt-m%C3%A3-nster-protocol-with-rituximab-and-consolidative-autologous-transplantation
#22
JOURNAL ARTICLE
Alessandro Broccoli, Lisa Argnani, Gabriele Gugliotta, Cinzia Pellegrini, Beatrice Casadei, Gianmarco Bagnato, Marianna Gentilini, Vittorio Stefoni, Pier Luigi Zinzani
INTRODUCTION: Intensive treatment approaches are required for adult patients with Burkitt lymphoma (BL), although an univocal standard of care still does not exist. The use of frontline autologous stem cells transplantation (ASCT) is debated. PATIENTS AND METHODS: Between 2004 and 2020, 50 patients with BL were treated with the Berlin-Frankfurt-Münster (BFM). Treatment plan consisted of 3 blocks, A (ifosfamide, vincristine, methotrexate, etoposide, and cytarabine), B (vincristine, cyclophosphamide, methotrexate, and doxorubicin), and C (vindesine, methotrexate, etoposide, and cytarabine), each repeated twice, every 28 days...
February 10, 2024: Oncologist
https://read.qxmd.com/read/38329919/gastric-burkitt-s-monomorphic-post-transplant-lymphoproliferative-disorder-after-kidney-transplantation-a-case-report
#23
JOURNAL ARTICLE
Yusuke Yoshimura, Tatsuya Suwabe, Arisa Fujiki, Daisuke Kaji, Yuki Asano-Mori, Yuki Oba, Hiroki Mizuno, Masayuki Yamanouchi, Kiho Tanaka, Eiko Hasegawa, Katsuyuki Miki, Takayoshi Yokoyama, Yuki Namamura, Yasuo Ishii, Satoshi Yamashita, Kei Kono, Keiichi Kinowaki, Yutaka Takazawa, Naoki Sawa, Yoshifumi Ubara
We report on a 53-year-old Japanese man diagnosed with gastric Burkitt's monomorphic post-transplant lymphoproliferative disorder (B-PTLD) after endoscopy for gastric discomfort 28 months after the patient underwent renal transplantation in Ethiopia. Serum Epstein-Barr virus (EBV) tests were negative before transplantation, but the tumor cells collected from a gastric biopsy showed positive EBV-encoded small RNAs (EBER) at B-PTLD onset. Intensive treatment started with R(rituximab)-CHOP therapy and continued with DA-EPOCH-R therapy has been effective, and relapse has not yet occurred...
February 8, 2024: Clinical Nephrology
https://read.qxmd.com/read/38313301/comparable-efficacy-of-oral-bendamustine-versus-intravenous-administration-in-treating-hematologic-malignancies
#24
Megan J Cracchiolo, Lisa Davis, Andrew P Matiatos, Dan W Davini, Muhammad Husnain, Richard J Simpson, Vasilios Voudouris, Emmanuel Katsanis
Purpose: The purpose of this study was to analyze potential differences in antitumor efficacy and pharmacokinetics between intravenous (IV) bendamustine (BEN) and a novel orally administered bendamustine agent (PO) that is utilizing the beneficial properties of superstaturated solid dispersions formulated in nanoparticles. Methods: Pharmacokinetics of IV versus PO BEN were determined by analysis of plasma samples collected from NSG mice treated with either IV or PO BEN. Plasma samples were analyzed using liquid chromatography-mass spectrometry (LC/MS/MS) following a liquid-liquid extraction to determine peak BEN concentration (Cmax), area under the concentration-time curve (AUC) and the half-life (t1/2) in-vivo ...
January 16, 2024: Research Square
https://read.qxmd.com/read/38312196/a-retrospective-cohort-study-to-evaluate-the-outcomes-of-hiv-associated-high-grade-b-cell-non-hodgkin-lymphoma-nhl-treated-with-dose-adjusted-epoch-r-regimen
#25
JOURNAL ARTICLE
Jayashree Thorat, Manju Sengar, Raajit Chanana, Akhil Kapoor, Ajay Singh, Avinash Bonda, Hari Menon, Bhausaheb Bagal, Siddharth Laskar, Nehal Khanna, Jayant Shastri Goda, Epari Sridhar, Sumeet Gujral, Archi Agarwal, Sheela Sawant, Anuprita Daddi, Tanuja Shet, Netra Ghandade, Hasmukh Jain
UNLABELLED: High-grade B-cell NHL's are more common in seropositive patients. They are biologically different from their seronegative counterparts. We report our analysis on our cohort of patients who were treated with DA-EPOCH(+/-R). We retrospectively analyzed treatment-naïve HIV-associated High-grade B-cell NHL patients (aged ≥ 18) treated with DA-EPOCH(+/-R) regimen from 2011 to 2015. Descriptive statistics were summarized with median and range; survival outcomes were analyzed with Kaplan-Meier method...
January 2024: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/38298550/uterine-burkitt-lymphoma-with-rare-extranodal-deposits-in-the-bone-breast-and-sacral-canal-a-case-report
#26
Xu-Sheng Liu, Chao Liu, Yi-Jia Chen, Dao-Bing Zeng, Ya-Lan Wang, Zhi-Jun Pei
Burkitt lymphoma is a highly invasive non-Hodgkin lymphoma. Sporadic Burkitt's lymphoma is commonly found in the abdomen. However, Burkitt lymphoma infiltrating the uterus is uncommon in occurrence. We report the results of 18 F-FDG PET/CT examination of a 36-year-old woman. The report indicates that in addition to the strong uptake of FDG imaging agent in the uterus, bilateral cervical and abdominal lymph nodes also have strong activity. At the same time, it was also found that bilateral small breast nodules, sacral canal and multiple bones in the whole body showed a radiation uptake pattern similar to that of the uterus...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38298419/maternal-autoimmune-disease-and-its-association-with-childhood-cancer-a-population-based-case-control-study-in-denmark
#27
JOURNAL ARTICLE
Helen T Orimoloye, Nicholas Nguyen, Chuanjie Deng, Chai Saechao, Beate Ritz, Jorn Olsen, Johnni Hansen, Julia E Heck
BACKGROUND: Autoimmune diseases have been linked to an increased risk of pregnancy-related complications. A family history of autoimmune diseases may be related to the risk of childhood cancer based on similar histocompatibility antigens. We utilized data from national registries in Denmark to examine associations between maternal autoimmune disease and cancer in their offspring. METHODS: We linked data from several national registries in Denmark to identify childhood cancer cases in children <20 years diagnosed between 1977 to 2016...
June 2024: EJC Paediatr Oncol
https://read.qxmd.com/read/38297237/laboratory-and-clinical-features-of-tumor-lysis-syndrome-in-children-with-non-hodgkin-lymphoma-and-evaluation-of-long-term-renal-functions-in-survivors
#28
JOURNAL ARTICLE
Selcen Bozkurt, Dildar Bahar Genc, Sema Vural
OBJECTIVE: The purpose of our study is to investigate the laboratory and clinical features of tumor lysis syndrome (TLS) and acute kidney injury (AKI) in childhood non-Hodgkin lymphomas (NHL) and to reveal their impact on long term kidney function in survivors. METHODS: Our single-center retrospective study included 107 patients (0-18 years old) with NHL who were admitted and treated at our hospital between 1998 and 2020. The relationship between TLS and age, gender, histopathological subgroup, tumor stage, lactate dehydrogenase (LDH) level at presentation, bone marrow and kidney involvement were assessed...
January 31, 2024: BMC Pediatrics
https://read.qxmd.com/read/38297129/7-dehydrocholesterol-is-an-endogenous-suppressor-of-ferroptosis
#29
JOURNAL ARTICLE
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira Dos Santos, Palina Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M Lorenz, Viktoria Kunz, Helene Nehring, Thamara N Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G Doll, Emily L Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann M Wehman, Thiago C Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B Sathian, David B Konrad, Douglas F Covey, Bernhard Michalke, Kurt Bommert, Ralf C Bargou, Ana Garcia-Saez, Derek A Pratt, Maria Fedorova, Andreas Trumpp, Marcus Conrad, José Pedro Friedmann Angeli
Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation1,2 . Here, we identify proferroptotic activity of 7-dehydrocholesterol reductase (DHCR7) and an unexpected prosurvival function of its substrate, 7-dehydrocholesterol (7-DHC). Although previous studies suggested that high concentrations of 7-DHC are cytotoxic to developing neurons by favouring lipid peroxidation3 , we now show that 7-DHC accumulation confers a robust prosurvival function in cancer cells...
January 31, 2024: Nature
https://read.qxmd.com/read/38292731/a-case-of-peritoneal-burkitt-s-lymphoma-mimic-of-peritoneal-tuberculosis
#30
Bei Feng, Qianfeng Ma, Huiwei Wang, Tingting Zhao, Yaxin Tian, Yiyuan Dong, Qian Zhao
Peritoneal lymphomatosis is a rare presentation of lymphoma that can mimic peritoneal tuberculosis. The computed tomography findings in both conditions include omental caking, thickening, and nodularity. We report the case of a 41-year-old man who presented with intermittent abdominal pain and distension. Abdominal CT initially suggested peritoneal tuberculosis due to the thickening of the peritoneum and greater omentum with multiple nodules. However, 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) images showed diffuse metabolic activity increase in the thickened peritoneum, omentum, and mesentery...
2024: Respiratory Medicine Case Reports
https://read.qxmd.com/read/38288575/insights-into-the-molecular-mechanisms-of-h-pylori-associated-b-cell-lymphoma
#31
REVIEW
Kritika Malik, Prashant Kodgire
Cancer research has extensively explored various factors contributing to cancer development, including chemicals, drugs, smoking, and obesity. However, the role of bacterial infections in cancer induction remains underexplored. In particular, the mechanisms underlying H. pylori -induced B-cell lymphoma, a potential consequence of bacterial infection, have received little attention. In recent years, there has been speculation about contagious agents causing persistent inflammation and encouraging B-lymphocyte transition along with lymphomagenesis...
January 30, 2024: Critical Reviews in Microbiology
https://read.qxmd.com/read/38280044/fli-1-is-expressed-in-a-wide-variety-of-hematolymphoid-neoplasms-a-special-concern-in-the-differential-diagnosis
#32
JOURNAL ARTICLE
Uiju Cho, Hee Jeong Cha, Hyun Jung Kim, Soo Kee Min, Hee Kyung Kim, Hye Ra Jung, Gyeongsin Park, Ji Eun Kim
Friend Leukemia Virus Integration 1 (FLI-1) is a member of E26 transformation-specific family of transcription factors that participates in hematopoietic and vascular endothelial cell development. Immunohistochemical detection of FLI-1 has been widely used to diagnose vascular tumors or, more evidently, Ewing's sarcoma. However, the expression pattern of FLI-1 in hematolymphoid neoplasms remains unclear. Therefore, in this study, we aimed to investigate the expression of FLI-1 in these tumors, focusing on high-grade lesions, which presents a diagnostic challenge by mimicking Ewing's sarcoma...
January 27, 2024: Clinical and Experimental Medicine
https://read.qxmd.com/read/38279758/oxadiazole-derivatives-of-diclofenac-as-an-anti-proliferative-agent-for-b-cell-non-hodgkin-lymphoma-an-in-vitro-and-in-silico-studies
#33
JOURNAL ARTICLE
Shaista Qayyum, Almas Jabeen, Sajda Ashraf, Faiza Seraj, Khalid Mohammad Khan, Rafat Ali Siddiqui, Zaheer Ul-Haq
BACKGROUND: Non-Hodgkin lymphoma of B cell origin is the common type of lymphoma- related malignancy with poor response rate with conventional front-line therapies. AIM: The aim of the present study was to investigate the potential of new anti-inflammatory oxadiazole derivatives of Diclofenac as an anti-lymphoma agent through in vitro and in silico approaches. METHOD: The compound (II) showed anti-lymphoma activity against both follicular and Burkitt's lymphoma cells, whereas compound (V) inhibited follicular lymphoma cells only...
January 25, 2024: Medicinal Chemistry
https://read.qxmd.com/read/38275109/-retracted-microrna%C3%A2-520a-attenuates-proliferation-of-raji-cells-through-inhibition-of-akt1-nf%C3%A2-%C3%AE%C2%BAb-and-perk-eif2%C3%AE-signaling-pathway
#34
Xiaojuan Wang, Pei Wang, Yan Zhu, Zhi Zhang, Jinqian Zhang, Hongwei Wang
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that a pair of the lanes featured in the western blot gel for Fig. 3B on p. 1705 were strikingly similar, suggesting that the same data may have been imported into the figure to represent data that were intended to show the results from differently performed experiments. In addition, the western data shown in Fig. 6 on p. 1706 for the GRP78 and the p‑PERK proteins also appeared to be strikingly similar, such that the same data may have also been inserted into this figure to show the results from different experiments...
March 2024: Oncology Reports
https://read.qxmd.com/read/38269317/a-dental-extraction-revealing-a-multisystem-burkitt-s-lymphoma-a-case-report
#35
Fatima Chait, Nourrelhouda Bahlouli, Khadija Laasri, Kaouthar Sfar, Najat Lamalmi, Nazik Allali, Siham El Haddad, Latifa Chat
Burkitt's lymphoma is rare but highly aggressive and very fast-growing B-cell non-Hodgkin's lymphoma (NHL). It can affect any organ such as the central nervous system, jaw, intestines, kidneys, ovaries, and other organs. It results from the malignant evolution and proliferation of B-type lymphoid cells. The diagnosis is based on a biopsy of a tumor mass or bone marrow aspiration revealing the presence of tumor cells. We report the case of a 7 year old child who was referred for a gingival swelling evolving since 1 month following a dental extraction...
2024: Global Pediatric Health
https://read.qxmd.com/read/38253636/pich-deficiency-limits-the-progression-of-myc-induced-b-cell-lymphoma
#36
JOURNAL ARTICLE
María Castejón-Griñán, Eliene Albers, Lucía Simón-Carrasco, Paula Aguilera, Mauro Sbroggio, David Pladevall-Morera, Andreas Ingham, Ernest Lim, Alba Guillen-Benitez, Elena Pietrini, Michael Lisby, Ian D Hickson, Andres J Lopez-Contreras
Plk1-interacting checkpoint helicase (PICH) is a DNA translocase involved in resolving ultrafine anaphase DNA bridges and, therefore, is important to safeguard chromosome segregation and stability. PICH is overexpressed in various human cancers, particularly in lymphomas such as Burkitt lymphoma, which is caused by MYC translocations. To investigate the relevance of PICH in cancer development and progression, we have combined novel PICH-deficient mouse models with the Eμ-Myc transgenic mouse model, which recapitulates B-cell lymphoma development...
January 23, 2024: Blood Cancer Journal
https://read.qxmd.com/read/38249231/ileocaecal-intussusception-due-to-burkitt-lymphoma-a-surgical-and-haematological-emergency
#37
Mostafa Elkhawaga, Bryony Ross, Ella Sugo, Chelsea Reedman-Hawes, Hasitha Balasuriya
Intussusception is the protrusion and invagination of a segment of the bowel, referred to as the intussusceptum, into another adjacent segment known as the intussuscipiens. The age range during which intussusception is most observed in children is between three and 18 months. Unlike intussusceptions in children, where the cause is often idiopathic, a specific underlying factor is discernible in a significant majority of cases among adults. In this article, we will present a case of intussusception in an adolescent caused by Burkitt lymphoma...
December 2023: Curēus
https://read.qxmd.com/read/38246760/-sporadic-burkitt-lymphoma-of-the-epiglottis-in-an-adult-female-a-case-report
#38
JOURNAL ARTICLE
Y T Zheng, W Li
No abstract text is available yet for this article.
January 7, 2024: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://read.qxmd.com/read/38244019/primary-manifestation-of-hiv-related-burkitt-lymphoma-in-the-oral-and-maxillofacial-regions
#39
Nilton José da Silva Filho, Diovana de Melo Cardoso, Giseli Mitsuy Kayahara, José Cândido Caldeira Xavier-Júnior, Gabriel Macedo Cortopassi, Felipe Paiva Fonseca, Glauco Issamu Miyahara, Daniel Galera Bernabé, Vitor Bonetti Valente
BACKGROUND: Burkitt lymphoma (BL) is a subtype of non-Hodgkin lymphoma. It is strongly associated with HIV infection and has a highly aggressive clinical course. The involvement of the maxillofacial region in BL has rarely been reported. CASE DESCRIPTION: A 36-year-old woman with HIV-positive status had painless bilateral swelling of the oral mucosa and middle and lower thirds of the face. Microscopic analysis of the oral lesion revealed an atypical lymphoid infiltrate with a starry sky pattern...
January 20, 2024: Journal of the American Dental Association
https://read.qxmd.com/read/38237141/sox11-is-a-novel-binding-partner-and-endogenous-inhibitor-of-samhd1-ara-ctpase-activity-in-mantle-cell-lymphoma
#40
JOURNAL ARTICLE
Mohammad Hamdy Abdelrazak Morsy, Ingrid Lilienthal, Martin Lord, Magali Merrien, Agata Magdalena Wasik, Virginia Amador, Marta Sureda-Gómez, Henrik J Johansson, Janne Lehtiö, Beatriz García-Torre, Jose Ignacio Martin-Subero, Nikolaos Tsesmetzis, Sijia Tao, Raymond F Schinazi, Baek Kim, Agnes L Sorteberg, Malin Wickström, Devon Sheppard, Georgios Z Rassidakis, Ian A Taylor, Birger Christensson, Elías Campo, Nikolas Herold, Birgitta Sander
The sterile alpha motif and histidine-aspartate (HD) domain containing protein 1 (SAMHD1) is a deoxynucleoside triphosphate triphosphohydrolase with ara-CTPase activity that confers cytarabine (ara-C) resistance in several haematological malignancies. Targeting SAMHD1's ara-CTPase activity has recently been demonstrated to enhance ara-C efficacy in acute myeloid leukemia. Here, we identify the transcription factor SRY-related HMG-box containing protein 11 (SOX11) as a novel direct binding partner and first known endogenous inhibitor of SAMHD1...
January 18, 2024: Blood
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