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Uropathogen

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https://www.readbyqxmd.com/read/28533857/antibiogram-profile-of-uropathogens-isolated-at-bahir-dar-regional-health-research-laboratory-centre-northwest-ethiopia
#1
Awoke Derbie, Derese Hailu, Daniel Mekonnen, Bayeh Abera, Gashaw Yitayew
INTRODUCTION: Antimicrobial resistance among bacteria that cause urinary tract infection (UTI) has been increasing since the introduction of chemotherapy. This study was aimed to assess the types of isolates from patients with UTI and to determine their current antimicrobial susceptibility profile. METHODS: A record based retrospective analysis of bacterial uropathogens processed in the period of January 2012 to December 2014 at Bahir Dar Health Research Laboratory Center (BRHRLC) was determined...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28532269/antimicrobial-susceptibility-of-uropathogens-isolated-from-cambodian-children
#2
Anirban Mandal, Puneet Kaur Sahi
No abstract text is available yet for this article.
May 22, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28506090/rational-design-strategies-for-fimh-antagonists-new-drugs-on-the-horizon-for-urinary-tract-infection-and-crohn-s-disease
#3
Laurel K Mydock-McGrane, Thomas J Hannan, James W Janetka
The bacterial adhesin FimH is a virulence factor and an attractive therapeutic target for urinary tract infection (UTI) and Crohn's Disease (CD). Located on type 1 pili of uropathogenic E. coli (UPEC), the FimH adhesin plays an integral role in the pathogenesis of UPEC. Recent efforts have culminated in the development of small-molecule mannoside FimH antagonists that target the mannose-binding lectin domain of FimH, inhibiting its function and preventing UPEC from binding mannosylated host cells in the bladder, thereby circumventing infection...
May 16, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28505911/re-comprehensive-mutagenesis-of-the-fims-promoter-regulatory-switch-reveals-novel-regulation-of-type-1-pili-in-uropathogenic-escherichia-coli
#4
https://www.readbyqxmd.com/read/28505288/effect-of-different-antibiotics-on-biofilm-produced-by-uropathogenic-escherichia-coli-isolated-from-children-with-urinary-tract-infection
#5
María José González, Luciana Robino, Victoria Iribarnegaray, Pablo Zunino, Paola Scavone
Recurrent urinary tract infections (UTI) occur frequently in children and women. Intracellular bacterial communities (IBC) and biofilm formation by Escherichia coli are risk factors for recurrence. The aim of the present study was to evaluate the effect of different antibiotics on biofilms by E. coli strains isolated from children with UTI and to correlate virulence factors and IBC with biofilm formation. 116 E. coli strains were tested for biofilm formation using the crystal violet microplate technique. 58...
May 12, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28497052/etiological-and-resistance-profile-of-bacteria-involved-in-urinary-tract-infections-in-young-children
#6
Antonio Sorlózano-Puerto, José María Gómez-Luque, Juan de Dios Luna-Del-Castillo, José María Navarro-Marí, José Gutiérrez-Fernández
Background. The objective of this study was to identify the bacteria most frequently responsible for urinary tract infection (UTI) in the population of under-2-year-olds in our geographic area and to evaluate the activity of antibiotics widely used for UTI treatment during a 4-year study period. Materials and Methods. A retrospective analysis was conducted of data on the identification and susceptibility of microorganisms isolated in urine samples from children under 2 years of age. Results. A total of 1,045 uropathogens were isolated...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28497048/antimicrobial-resistance-patterns-in-women-with-positive-urine-culture-does-menopausal-status-make-a-significant-difference
#7
Pawel Miotla, Katarzyna Romanek-Piva, Michal Bogusiewicz, Ewa Markut-Miotla, Aneta Adamiak, Andrzej Wróbel, Małgorzata Zebrowska, Sara Wawrysiuk, Katarzyna Mendyk, Ewa Rechberger, Agata Jakubczak, Tomasz Rechberger
Aim. Urinary tract infection (UTI) is considered one of the most common bacterial infections in women. The aim of this study was to investigate the types of uropathogens present, as well as the degree of antimicrobial drug resistance seen among premenopausal (n = 2748) and postmenopausal (n = 1705) women with uncomplicated UTI. Methods. Urinary samples (n = 4453) collected from women with UTI were analyzed in terms of uropathogens present. These were considered as positive if bacterial growth was ≥10(5) colony forming units (CFUs)/mL...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28495024/live-cell-nanoscopy-in-antiadhesion-therapy
#8
Joan A Geoghegan, Timothy J Foster, Pietro Speziale, Yves F Dufrêne
Live-cell nanoscopy has contributed significantly to assessing the inhibition of adhesion of uropathogenic Escherichia coli and Staphylococcus aureus by glycoconjugates and monoclonal antibodies, respectively, and of S. aureus surface attachment and cell-cell association by a synthetic peptide. This new technology shows promise for the development of antiadhesion therapies against bacterial pathogens.
May 8, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28491245/frequency-evaluation-of-genes-encoding-siderophores-and-the-effects-of-different-concentrations-of-fe-ions-on-growth-rate-of-uropathogenic-escherichia-coli
#9
Behnoush Khasheii, Shaghayegh Anvari, Ailar Jamalli
BACKGROUND AND OBJECTIVES: Bacteria need iron for growth and most of them can actively acquire Fe ions using especial iron-chelating proteins which named siderophores. We aimed to determine the frequencies of iucA, iroN and irp2 genes in the uropathogenic Escherichia coli (UPEC) isolates. We also analyzed the effects of siderophore genes beside iron supplements on growth rate of the isolates. MATERIALS AND METHODS: Totally, 170 E. coli strains were isolated from urinary tract infections and the presence of 3 siderophore genes were analyzed using PCR among them...
December 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28489862/novel-genes-associated-with-enhanced-motility-of-escherichia-coli-st131
#10
Asha Kakkanat, Minh-Duy Phan, Alvin W Lo, Scott A Beatson, Mark A Schembri
Uropathogenic Escherichia coli (UPEC) is the cause of ~75% of all urinary tract infections (UTIs) and is increasingly associated with multidrug resistance. This includes UPEC strains from the recently emerged and globally disseminated sequence type 131 (ST131), which is now the dominant fluoroquinolone-resistant UPEC clone worldwide. Most ST131 strains are motile and produce H4-type flagella. Here, we applied a combination of saturated Tn5 mutagenesis and transposon directed insertion site sequencing (TraDIS) as a high throughput genetic screen and identified 30 genes associated with enhanced motility of the reference ST131 strain EC958...
2017: PloS One
https://www.readbyqxmd.com/read/28488084/loop-diuretics-diminish-hemolysis-induced-by-%C3%AE-hemolysin-from-escherichia-coli
#11
Carl Martin Söderström, Steen K Fagerberg, Mette B Brogaard, Jens Leipziger, Marianne Skals, Helle A Praetorius
Uropathogenic Escherichia coli often produce the virulence factor α-hemolysin (HlyA), and the more severe the infection, the likelier it is to isolate HlyA-producing E. coli from patients. HlyA forms pores upon receptor-independent insertion of the toxin into biological membranes and it has been substantiated that HlyA-induced hemolysis is amplified by toxin-induced ATP release and activation of P2X receptors. Thus, hemolysis inflicted by HlyA is a protracted process involving signal transduction. It consists of early, marked cell shrinkage followed by swelling and eventually lysis...
May 9, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28486532/antibiotic-resistance-rates-and-physician-antibiotic-prescription-patterns-of-uncomplicated-urinary-tract-infections-in-southern-chinese-primary-care
#12
Carmen Ka Man Wong, Kenny Kung, Philip Lung Wai Au-Doung, Margaret Ip, Nelson Lee, Alice Fung, Samuel Yeung Shan Wong
Uncomplicated urinary tract infections (UTI) are common in primary care. Whilst primary care physicians are called to be antimicrobial stewards, there is limited primary care antibiotic resistance surveillance and physician antibiotic prescription data available in southern Chinese primary care. The study aimed to investigate the antibiotic resistance rate and antibiotic prescription patterns in female patients with uncomplicated UTI. Factors associated with antibiotic resistance and prescription was explored...
2017: PloS One
https://www.readbyqxmd.com/read/28485709/occurrence-and-characterization-of-class-1-integrons-in-escherichia-coli-from-healthy-individuals-and-those-with-urinary-infection
#13
Clarisse Oliveira-Pinto, Cristiane Diamantino, Patrícia L Oliveira, Mariana P Reis, Patrícia S Costa, Magna C Paiva, Regina M D Nardi, Paula P Magalhães, Edmar Chartone-Souza, Andréa M A Nascimento
PURPOSE: Class 1 integrons are among the main vehicles that facilitate the spread of antibiotic-resistance genes, with serious public health consequences. The aim of this cross-sectional study was to investigate the presence of class 1 integrons and to characterize their variable regions, as well as the antimicrobial resistance profiles and phylogenetic groups of a collection of Escherichia coli isolates recovered from healthy subjects (n=42) and those with urinary infection (n=40). METHODOLOGY: The methods used included PCR, sequencing and antimicrobial susceptibility testing...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28479906/factors-associated-with-community-acquired-urinary-tract-infections-among-adults-attending-assessment-centre-mulago-hospital-uganda
#14
Deus Kabugo, Samuel Kizito, Dave Dhara Ashok, Kiwanuka Alexander Graham, Ronald Nabimba, Sandra Namunana, M Richard Kabaka, Beatrice Achan, Florence C Najjuka
BACKGROUND: Urinary tract infections (UTI) are a common medical problem affecting the general population and thus commonly encountered in medical practice, with the global burden of UTIs at about 150 million people. Because uropathogens largely originate from colonic flora, they are easy to predict, and this is the rationale for empirical treatment in Community Acquired-UTI (CA-UTIs). With the increasing prevalence of drug-resistant bacteria among adults with CA-UTI in Uganda, it is no longer adequate to manage CA-UTIs on empiric regimen without revising the susceptibility patterns of common CA-UTI causative agents...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28478807/aqueous-extract-from-orthosiphon-stamineus-leaves-prevents-bladder-and-kidney-infection-in-mice
#15
S Sarshar, S Brandt, M R Asadi Karam, M Habibi, S Bouzari, M Lechtenberg, U Dobrindt, X Qin, F M Goycoolea, A Hensel
BACKGROUND: Extracts from the leaves of Orthosiphon stamineus are used in phytotherapy for treatment of uncomplicated urinary tract infections. PURPOSES: Evaluation of an aqueous extract against infection with uropathogenic Escherichia coli in vivo; investigation of underlying microbiological mechanisms. STUDY DESIGN: In vivo studies in mice and in vitro investigations on cytotoxicity, antiadhesive potential, influence on bacterial gene expression and quorum sensing...
May 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28475789/inappropriate-empirical-treatment-of-uncomplicated-cystitis-in-thai-women-lessons-learned
#16
Nattapol Pruetpongpun, Thana Khawcharoenporn, Pansachee Damronglerd, Nuntra Suwantarat, Anucha Apisarnthanarak, Sasinuch Rutjanawech
A prospective study conducted in a Thai general practice clinic demonstrated a high prevalence (91.3%) of inappropriate empirical antibiotic use in women with uncomplicated cystitis and 42.6% Escherichia coli fluoroquinolone resistance. An annual update of antimicrobial resistance surveillance data of uropathogens may permit targeted treatment of patients in hospital care.
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28473396/complete-genome-sequence-of-the-uropathogenic-escherichia-coli-strain-nu14
#17
Kurosh S Mehershahi, Swaine L Chen
Escherichia coli is the most common bacterium causing urinary tract infections in humans. We report here the complete genome sequence of the uropathogenic Escherichia coli strain NU14, a clinical pyelonephritis isolate used for studying pathogenesis.
May 4, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28471659/urinary-tract-infection-which-conformation-of-the-bacterial-lectin-fimh-is-therapeutically-relevant
#18
Katharina Mayer, Deniz Eris, Oliver Schwardt, Christoph P Sager, Said Rabbani, Simon Kleeb, Beat Ernst
Frequent antibiotic treatment of urinary tract infections has resulted in the emergence of antimicrobial resistance, necessitating alternative treatment options. One such approach centers around FimH antagonists that block the bacterial adhesin FimH, which would otherwise mediate binding of uropathogenic Escherichia coli to the host urothelium to trigger the infection. Although the FimH lectin can adopt three distinct conformations, the evaluation of FimH antagonists has mainly been performed with a truncated construct of FimH locked in one particular conformation...
May 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28471379/supramolecular-recognition-of-escherichia-coli-bacteria-by-fluorescent-oligo-phenyleneethynylene-s-with-mannopyranoside-termini-groups
#19
Enrique Arias, Maria Teresa Méndez, Eduardo Arias, Ivana Moggio, Antonio Ledezma, Jorge Romero, Giancarlo Margheri, Emilia Giorgetti
Escherichia coli is one the most common bacteria responsible of uropathogenic diseases, which motives the search for rapid and easy methods of detection. By taking advantage of the specific interactions between mannose and type 1 fimbriae, in this work two fluorescent phenyleneethynylene (PE) trimers bearing one or two 4-aminophenyl-α-D-mannopyranoside termini groups were synthesized for the detection of E. coli. Three bacterial strains: ORN 178 (fimbriae I expression), ORN 208 (mutant serotype with no fimbriae expression) and one obtained from a local hospital (SS3) were used...
May 4, 2017: Sensors
https://www.readbyqxmd.com/read/28470309/characterization-of-non-dialyzable-constituents-from-cranberry-juice-that-inhibit-adhesion-co-aggregation-and-biofilm-formation-by-oral-bacteria
#20
C C Neto, K A Penndorf, M Feldman, S Meron-Sudai, Z Zakay-Rones, D Steinberg, M Fridman, Y Kashman, I Ginsburg, I Ofek, E I Weiss
An extract prepared from cranberry juice by dialysis known as nondialyzable material (NDM) has been shown previously to possess anti-adhesion activity toward microbial species including oral bacteria, uropathogenic Escherichia coli and Helicobacter pylori. Bioassay-guided fractionation of cranberry NDM was therefore undertaken to identify the anti-adhesive constituents. An aqueous acetone-soluble fraction (NDMac) obtained from Sephadex LH-20 inhibited adhesion-linked activities by oral bacteria, including co-aggregation of oral bacteria Fusobacterium nucleatum with Streptococcus sanguinis or Porphyromonas gingivalis, and biofilm formation by Streptococcus mutans...
May 24, 2017: Food & Function
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