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https://www.readbyqxmd.com/read/28810536/drug-resistant-gram-negative-uropathogens-a-review
#1
REVIEW
Saeed Khoshnood, Mohsen Heidary, Reza Mirnejad, Aghil Bahramian, Mansour Sedighi, Habibollah Mirzaei
Urinary tract infection(UTI) caused by Gram-negative bacteria is the second most common infectious presentation in community medical practice. Approximately 150 million people are diagnosed with UTI each year worldwide. Drug resistance in Gram-negative uropathogens is a major global concern which can lead to poor clinical outcomes including treatment failure, development of bacteremia, requirement for intravenous therapy, hospitalization, and extended length of hospital stay. The mechanisms of drug resistance in these bacteria are important due to they are often not identified by routine susceptibility tests and have an exceptional potential for outbreaks...
August 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28804616/zinc-oxide-nanoparticle-reduced-biofilm-formation-and-antigen-43-expressions-in-uropathogenic-escherichiacoli
#2
Ali Shakerimoghaddam, Ezzat A Ghaemi, Ailar Jamalli
OBJECTIVES: This study aimed to investigate the effect of zinc oxide nanoparticles (ZnO-np) on biofilm formation and expression of the flu gene in uropathogenic Escherichia coli (UPEC) strains. MATERIALS AND METHODS: Minimum inhibitory concentration (MIC) of ZnO-np was determined by agar dilution method. The effect of MIC and sub-MIC concentrations of ZnO-np on biofilm formation were determined by microtiter plate assay. The expression level of the flu gene was assessed by Real-Time PCR assay...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28804585/detection-of-ctx-m-15-among-uropathogenic-escherichia-coli-isolated-from-five-major-hospitals-in-tripoli-libya
#3
Abdulaziz Zorgani, Asma Almagatef, Najib Sufya, Abdulla Bashein, Abdullatif Tubbal
OBJECTIVES: Multidrug resistance (MDR) and emergence of extended-spectrum β-lactamases (ESBLs) among uropathogenic Escherichia coli have been reported worldwide, but there was no information on the detection of blaCTX-M-15 in major teaching hospitals in Libya. The aim of the study was to investigate the occurrence of CTX-M-15 β-lactamases producers isolated from five teaching hospitals in Tripoli, Libya. METHODS: A total of 346 urine samples were collected from hospitalized patients in five teaching hospitals with a diagnosis of urinary tract infection (UTI)...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28797714/profiling-the-urinary-microbiome-in-men-with-positive-versus-negative-biopsies-for-prostate-cancer
#4
Eva Shrestha, James R White, Shu-Han Yu, Ibrahim Kulac, Onur Ertunc, Angelo M De Marzo, Srinivasan Yegnasubramanian, Leslie A Mangold, Alan W Partin, Karen S Sfanos
PURPOSE: Studies demonstrating bacterial DNA and cultivable bacteria in urine samples have challenged the clinical dogma that urine is sterile. Furthermore, studies now indicate that dysbiosis of the urinary microbiome is associated with pathological conditions. We propose that the urinary microbiome may influence chronic inflammation observed in the prostate, leading to prostate cancer development and progression. We therefore aimed to profile the urinary microbiome in men with positive versus negative biopsies for prostate cancer...
August 7, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28791824/anti-enterococcal-activities-of-pentacyclic-triterpenes
#5
Dorota Wojnicz, Dorota Tichaczek-Goska, Kamila Korzekwa, Marta Kicia, Andrzej Hendrich
BACKGROUND: Asiatic (AA) and ursolic (UA) acids are widely studied phytochemicals, but their antimicrobial properties are still poorly understood. Therefore our research has focused on their activity against uropathogenic Enterococcus faecalis strains. OBJECTIVES: The aim of this research was to determine the influence of AA and UA on the growth, cell morphology, virulence factors and biofilm formation by E. faecalis strains. MATERIAL AND METHODS: AA and UA were purchased from Sigma-Aldrich...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28790187/antibiotic-susceptibility-testing-in-less-than-30-min-using-direct-single-cell-imaging
#6
Özden Baltekin, Alexis Boucharin, Eva Tano, Dan I Andersson, Johan Elf
The emergence and spread of antibiotic-resistant bacteria are aggravated by incorrect prescription and use of antibiotics. A core problem is that there is no sufficiently fast diagnostic test to guide correct antibiotic prescription at the point of care. Here, we investigate if it is possible to develop a point-of-care susceptibility test for urinary tract infection, a disease that 100 million women suffer from annually and that exhibits widespread antibiotic resistance. We capture bacterial cells directly from samples with low bacterial counts (10(4) cfu/mL) using a custom-designed microfluidic chip and monitor their individual growth rates using microscopy...
August 8, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28765918/tcpc-secreting-uropathogenic-e-coli-promoted-kidney-cells-to-secrete-mip-2-via-p38-mapk-pathway
#7
Yujie He, Jie Fang, Chong Zhang, Jun Pan, Qi Jin, Yingzhi Yang, Linyao Wang, Baoming Wang, Dayong Zhang, Jianping Pan
Pyelonephritis is an infection of the upper urinary tract with characteristic histological change to neutrophil infiltration in the kidney. The majority of pyelonephritis is caused by uropathogenic Escherichia (E.) coli (UPEC) bearing distinct virulence factors. Toll/interleukin‑1 receptor domain‑containing protein C (TcpC) encoded by E. coli is an important virulence factor in the majority of strains of UPEC and inhibits macrophage‑mediated innate immunity, which serves an essential role in the pathogenesis of pyelonephritis...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28764161/providencia-rettgeri-an-emerging-nosocomial-uropathogen-in-an-indwelling-urinary-catheterised-patient
#8
Siddharth Sagar, Nagalakshmi Narasimhaswamy, Jessica D'Souza
Providencia rettgeri (P. rettgeri) is an ubiquitous organism but is seldom associated with human disease. We report the isolation of P. rettgeri from the urine sample of a 39-year-old male patient on prolonged Foley's catheterisation following a severe head injury. Identification of this organism was done by Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF) based systems. P. rettgeri is an emerging pathogen among long term catheterised patients. It reflects its ability to form biofilm on the surface of the indwelling catheter as well as the inherent urease producing property of the pathogen in question as a possible mechanism of pathogenesis...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28762433/incidence-and-molecular-characterization-of-the-extended-spectrum-beta-lactamase-producing-escherichia-coli-isolated-from-urinary-tract-infections-in-eastern-saudi-arabia
#9
Fahad A Mashwal, Salah H El Safi, Siju K George, Ahmed A Adam, Arulanantham Z Jebakumar
To find the prevalence of uropathogenic Escherichia coli (E. coli)-producing extended spectrum beta lactamase (ESBL) at King Fahd Military Medical Complex in Dhahran (KFMMC) and to detect the genes responsible for its production. In addition, we determined the pattern of multi-drug resistance among isolates. Methods: A total of 117 uropathogenic E. coli isolates were collected from KFMMC over a period of 4 months from March 2014 to June 2014. These were received in the Microbiology Laboratory at Prince Sultan Military College of Health Sciences (PSMCHS), Dhahran, Saudi Arabia for analysis...
July 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28759019/copper-import-in-escherichia-coli-by-the-yersiniabactin-metallophore-system
#10
Eun-Ik Koh, Anne E Robinson, Nilantha Bandara, Buck E Rogers, Jeffrey P Henderson
Copper plays a dual role as a nutrient and a toxin during bacterial infections. While uropathogenic Escherichia coli (UPEC) strains can use the copper-binding metallophore yersiniabactin (Ybt) to resist copper toxicity, Ybt also converts bioavailable copper to Cu(II)-Ybt in low-copper conditions. Although E. coli have long been considered to lack a copper import pathway, we observed Ybt-mediated copper import in UPEC using canonical Fe(III)-Ybt transport proteins. UPEC removed copper from Cu(II)-Ybt with subsequent re-export of metal-free Ybt to the extracellular space...
July 24, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28754265/evaluation-of-prevalence-immunogenicity-and-efficacy-of-fyua-iron-receptor-in-uropathogenic-escherichia-coli-isolates-as-a-vaccine-target-against-urinary-tract-infection
#11
Mehri Habibi, Mohammad Reza Asadi Karam, Saeid Bouzari
Uropathogenic Escherichia coli (UPEC) are among the most prevalent agents of urinary tract infections (UTIs). Antibiotic resistance reaches the need for alternative treatment approaches such as vaccination against UTIs. There is no ideal vaccine against UTIs, thus there is a need to evaluate different targets of uropathogens against UTIs. Ferric scavenger receptor FyuA in UPEC has the properties of an ideal vaccine candidate against UTIs. In the present study, the prevalence of FyuA among UPEC isolates, its immunogenicity with and without alum adjuvant, and its efficacy against experimental UTI were assessed...
July 25, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28741927/rapid-antibiotic-susceptibility-testing-of-uropathogenic-e-coli-by-tracking-sub-micron-scale-motion-of-single-bacterial-cells
#12
Karan Syal, Simon Shen, Yunze Yang, Shaopeng Wang, Shelley E Haydel, Nongjian Tao
To combat antibiotic resistance, a rapid antibiotic susceptibility testing (AST) technology that can identify resistant infections at disease onset is required. Current clinical AST technologies take 1-3 days, which is often too slow for accurate treatment. Here we demonstrate a rapid AST method by tracking sub-µm scale bacterial motion with an optical imaging and tracking technique. We apply the method to clinically relevant bacterial pathogens, Escherichia coli O157: H7 and uropathogenic E. coli (UPEC) loosely tethered to a glass surface...
July 25, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28739824/epigenetic-mechanisms-regulate-innate-immunity-against-uropathogenic-and-commensal-like-escherichia-coli-in-the-surrogate-insect-model-galleria-mellonella
#13
Miriam Heitmueller, André Billion, Ulrich Dobrindt, Andreas Vilcinskas, Krishnendu Mukherjee
Innate immunity-related genes in humans are activated during urinary tract infections (UTIs) caused by pathogenic strains of Escherichia coli but are suppressed by commensals. Epigenetic mechanisms play a pivotal role in the regulation of gene expression in response to environmental stimuli. To determine whether epigenetic mechanisms can explain the different behaviors of pathogenic and commensal bacteria, we infected larvae of the greater wax moth Galleria mellonella, a widely-used model insect host, with a uropathogenic E...
July 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28739804/role-of-the-disulfide-bond-in-stabilizing-and-folding-of-the-fimbrial-protein-drae-from-uropathogenic-escherichia-coli
#14
Justyna Pilipczuk, Beata Zalewska-Piątek, Piotr Bruździak, Jacek Czub, Milosz Wieczór, Marcin Olszewski, Marta Wanarska, Bogdan Nowicki, Danuta Augustin-Nowacka, Rafal Piątek
Dr fimbriae are homopolymeric adhesive organelles of uropathogenic Escherichia coli composed of DraE subunits, responsible for the attachment to host cells. These structures are characterized by enormously high stability resulting from the structural properties of an Ig-like fold of DraE. One feature of DraE and other fimbrial subunits that makes them peculiar among Ig-like domain-containing proteins is a conserved disulfide bond that joins their A and B strands. Here, we investigated how this disulfide bond affects the stability and folding/unfolding pathway of DraE...
July 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28735999/results-of-real-time-multiplex-polymerase-chain-reaction-assay-in-renal-transplant-recipients-with-sterile-pyuria
#15
M Sarier, M Demir, S Goktas, I Duman, M Buyukkinaci, Y Yuksel, S Tekin, A H Yavuz, A Sengul
Urinary tract infections are a major cause of morbidity and hospitalization after renal transplantation. Patients treated with immunosuppressive drugs suffer not only from common uropathogens but also from opportunistic infections caused by unusual uropathogens. Sterile pyuria is associated with numerous infectious agents including viruses, fungi, and atypical or fastidious organisms. The objective of this study was to investigate the pathogens using real-time multiplex polymerase chain reaction (rtMPCR) assay in sterile pyuria of renal transplant recipients...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28723468/trends-in-antibiotic-resistance-in-urologic-practice
#16
REVIEW
Hala Kandil, Emma Cramp, Tejal Vaghela
CONTEXT: The significant global upsurge in antimicrobial resistance, particularly among Enterobacteriaceae, represents a serious threat to health care systems. The implications for urologic practice are of particular concern. OBJECTIVE: To review trends in antibiotic resistance in urologic practice. EVIDENCE ACQUISITION: We report current European trends of resistance in Gram-negative uropathogens. EVIDENCE SYNTHESIS: In addition to β-lactam resistance, Gram-negative pathogens are often resistant to multiple drug classes, including aminoglycosides, fluoroquinolones, and carbapenems, commonly used to treat urologic infections...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28722010/a-shape-shifting-redox-foldase-contributes-to-proteus-mirabilis-copper-resistance
#17
Emily J Furlong, Alvin W Lo, Fabian Kurth, Lakshmanane Premkumar, Makrina Totsika, Maud E S Achard, Maria A Halili, Begoña Heras, Andrew E Whitten, Hassanul G Choudhury, Mark A Schembri, Jennifer L Martin
Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. Here we show that P. mirabilis ScsC (PmScsC) contributes to this defence mechanism by enabling swarming in the presence of copper. We also demonstrate that PmScsC is a thioredoxin-like disulfide isomerase but, unlike other characterized proteins in this family, it is trimeric. PmScsC trimerization and its active site cysteine are required for wild-type swarming activity in the presence of copper. Moreover, PmScsC exhibits unprecedented motion as a consequence of a shape-shifting motif linking the catalytic and trimerization domains...
July 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28710743/prevalence-of-tem-shv-and-ctx-m-genes-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-strains-isolated-from-urinary-tract-infections-in-adults
#18
Jayanti Jena, Rajesh Kumar Sahoo, Nagen Kumar Debata, Enketeswara Subudhi
Urinary tract infections (UTIs) are one of the major sources of widespread infectious diseases in the community as well as in the hospitals which increase the cause of morbidity and mortality. Prevalence of extended-spectrum-β-lactamase (ESBL)-producing uropathogenic E. coli isolates has been found to be increased rapidly across the world. The present study was undertaken to find out the frequency of bla TEM, bla CTX-M, and bla SHV genes among E. coli isolates from UTI and detect their sensitivity pattern...
August 2017: 3 Biotech
https://www.readbyqxmd.com/read/28709389/characterization-of-uropathogenic-e-coli-isolated-from-urinary-tract-infections-phylogenetic-typing-and-distribution-of-virulence-associated-traits
#19
A Salehzadeh, H Zamani
No abstract text is available yet for this article.
July 14, 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28707808/cytotoxic-necrotizing-factor-1-promotes-prostate-cancer-progression-through-activating-the-cdc42-pak1-axis
#20
Yaxiu Guo, Zhisong Zhang, Huiting Wei, Jingyu Wang, Junqiang Lv, Kai Zhang, Evan T Keller, Zhi Yao, Quan Wang
Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections and plays a role in prostatic carcinogenesis and prostate cancer (PCa) progression. However, the mechanisms through which UPEC promotes PCa development and progression are unclear. Cytotoxic necrotizing factor 1 (CNF1) is one of the most important UPEC toxins and its role in PCa progression has never been studied. We found that UPEC-secreted CNF1 promoted the migration and invasion of PCa cells and PCa metastasis. In vitro studies showed that CNF1 promotes pro-migratory and pro-invasive activity through entering PCa cells and activating Cdc42, which subsequently induced PAK1 phosphorylation and upregulation of MMP-9 expression...
July 14, 2017: Journal of Pathology
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