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Uropathogen

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https://www.readbyqxmd.com/read/28438119/dfi-seq-identification-of-environment-specific-gene-expression-in-uropathogenic-escherichia-coli
#1
Michelle Madelung, Tina Kronborg, Thomas Koed Doktor, Carsten Struve, Karen Angeliki Krogfelt, Jakob Møller-Jensen
BACKGROUND: During infection of the urinary tract, uropathogenic Escherichia coli (UPEC) are exposed to different environments, such as human urine and the intracellular environments of bladder epithelial cells. Each environment elicits a distinct bacterial environment-specific transcriptional response. We combined differential fluorescence induction (DFI) with next-generation sequencing, collectively termed DFI-seq, to identify differentially expressed genes in UPEC strain UTI89 during growth in human urine and bladder cells...
April 24, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28432491/anti-biofilm-activity-of-polyazolidinammonium-modified-with-iodine-hydrate-ions-against-microbial-biofilms-of-uropathogenic-coliform-bacteria
#2
O V Nechaeva, E I Tikhomirova, D A Zayarsky, N V Bespalova, E V Glinskaya, N F Shurshalova, B M Al Bayati, A I Babailova
The dynamics of microbial biofilm formation by standard strain and by clinical strains of uropathogenic coliform bacteria was investigated in vitro and the effect of sublethal concentrations of the polymer compound polyazolidinammonium modified with iodine hydrate ions on the initial stages of biofilm formation was assessed. Treatment of immunological plate wells with the polymeric compound prevented film formation, especially in case of clinical E. coli strain carrying FimH virulence gene.
April 21, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28428949/p2x1-p2x4-and-p2x7-receptor-knock-out-mice-expose-differential-outcome-of-sepsis-induced-by-%C3%AE-haemolysin-producing-escherichia-coli
#3
Anne-Sofie Greve, Marianne Skals, Steen K Fagerberg, Wulf Tonnus, Svend Ellermann-Eriksen, Richard J Evans, Andreas Linkermann, Helle A Praetorius
α-haemolysin (HlyA)-producing Escherichia coli commonly inflict severe urinary tract infections, including pyelonephritis, which comprises substantial risk for sepsis. In vitro, the cytolytic effect of HlyA is mainly mediated by ATP release through the HlyA pore and subsequent P2X1/P2X7 receptor activation. This amplification of the lytic process is not unique to HlyA but is observed by many other pore-forming proteins including complement-induced haemolysis. Since free hemoglobin in the blood is known to be associated with a worse outcome in sepsis one could speculate that inhibition of P2X receptors would ameliorate the course of sepsis...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28424831/-recurrent-and-catheter-associated-urinary-tract-infections-prophylaxis-and-prevention
#4
H Piechota
Urinay tract infection (UTI) as one of the most frequent bacterial infections in humans is of utmost relevance. Because of the rising prevalence of antimicrobial resistance, urinalysis should always include urine culture and a resistogram in order to avoid an unspecific selection and overuse of antibiotics. Prevention of recurrent UTI must first of all rule out predisposing uropathogenic conditions. Nowadays, a great variety of drugs, behavioral, and supportive treatment options can effectively minimize UTI recurrence...
April 19, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28421045/cranberry-juice-and-combinations-of-its-organic-acids-are-effective-against-experimental-urinary-tract-infection
#5
Heidi D Jensen, Carsten Struve, Søren B Christensen, Karen A Krogfelt
The antibacterial effect of cranberry juice and the organic acids therein on infection by uropathogenic Escherichia coli was studied in an experimental mouse model of urinary tract infection (UTI). Reduced bacterial counts were found in the bladder (P < 0.01) of mice drinking fresh cranberry juice. Commercially available cranberry juice cocktail also significantly reduced (P < 0.01) bacterial populations in the bladder, as did the hydrophilic fraction of cranberry juice (P < 0.05). Quinic, malic, shikimic, and citric acid, the preponderant organic acids in cranberry juice, were tested in combination and individually...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28419868/ciprofloxacin-resistance-in-uropathogenic-escherichia-coli-isolates-causing-community-acquired-urinary-infections-in-bras%C3%A3-lia-brazil
#6
Rafaella Christina Rocha Moreira da Silva, Paulo de Oliveira Martins Júnior, Laura Fernandes Gonçalves, Vicente de Paulo Martins, Ana Beatriz Fabrício de Melo, André Pitondo-Silva, Tatiana Amabile de Campos
OBJECTIVES: Considering the global concern of ciprofloxacin resistance, the aim of this study was to evaluate the characteristics of ciprofloxacin-resistant (CIP-R) Escherichia coli isolated from patients with community-acquired urinary tract infections (UTIs) in Brasília, Brazil. METHODS: CIP-R E. coli isolated from different outpatients between July 2013 and April 2014 in a tertiary hospital were analysed for antibiotic resistance profile, phylotype, uropathogenic E...
April 15, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28407430/chronic-urinary-tract-infections-in-patients-with-spinal-cord-lesions-biofilm-infection-with-need-for-long-term-antibiotic-treatment
#7
REVIEW
Nete Tofte, Alex C Y Nielsen, Hannah Trøstrup, Christine B Andersen, Michael Von Linstow, Birgitte Hansen, Fin Biering-Sørensen, Niels Høiby, Claus Moser
Patients suffering from spinal cord injuries resulting in complete or incomplete paraplegia or tetraplegia are highly disposed to frequent, recurrent or even chronic urinary tract infections (UTIs). The reason for the increased risk of acquiring UTIs is multifactorial, including reduced sensation of classical UTI symptoms, incomplete bladder emptying, frequent catheterizations or chronic urinary tract catheters. Biofilms in relation to UTIs have been shown both on catheters, on concrements or as intracellular bacterial communities (IBCs)...
April 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28403589/the-efficacy-of-an-association-of-palmitoylethanolamide-and-alpha-lipoic-acid-in-patients-with-chronic-prostatitis-chronic-pelvic-pain-syndrome-a-randomized-clinical-trial
#8
Bruno Giammusso, Rosaria Di Mauro, Renato Bernardini
BACKGROUND: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a complex condition, characterized by uncertain etiology and by limited response to therapy. The definition of CP/CPPS includes genitourinary pain with or without voiding symptoms in the absence of uropathogenic bacteria, as detected by standard microbiological methods, or another identifiable cause such as malignancy. The efficacy of various medical therapies, has been evaluated in clinical studies, but evidence is lacking or conflicting...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28402532/strain-specific-inhibition-of-the-adherence-of-uropathogenic-bacteria-to-bladder-cells-by-probiotic-lactobacillus-spp
#9
Dolores González de Llano, Amalia Arroyo, Nivia Cárdenas, Juan Miguel Rodríguez, M Victoria Moreno-Arribas, Begoña Bartolomé
Urinary tract infections (UTI), one of most common infections worldwide, face high recurrence rates and increasing antimicrobial resistance. Probiotic bacteria, especially of the genus Lactobacillus are considered a promising preventive and/or treatment therapy against UTI. In order to elucidate the mechanisms involved in these beneficial effects, we studied the impact of different Lactobacillus strains (L. salivarius UCM572, L. plantarum CLC17 and L. acidophilus 01) in the adherence of reference and clinical uropathogenic strains (Escherichia coli ATCC® 53503™, E...
April 11, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28396353/the-histidine-residue-of-qsec-is-required-for-canonical-signaling-between-qseb-and-pmrb-in-uropathogenic-escherichia-coli
#10
Erin J Breland, Ellisa W Zhang, Tomas Bermudez, Charles R Martinez, Maria Hadjifrangiskou
Two-component systems are prototypically comprised of a histidine kinase (sensor) and a response regulator (responder). The sensor kinases auto-phosphorylate at a conserved histidine residue, acting as a phospho-donor for subsequent phosphotransfer to and activation of a cognate response regulator. In rare cases, the histidine residue is also essential for response regulator de-phosphorylation via a reverse-phosphotransfer reaction. In this work, we present an example of a kinase that relies on reverse-phosphotransfer to catalyze the de-phosphorylation of its cognate partner...
April 10, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28391960/rapid-detection-of-urinary-tract-infections-via-bacterial-nuclease-activity
#11
Katie S Flenker, Elliot L Burghardt, Nirmal Dutta, William J Burns, Julia M Grover, Elizabeth J Kenkel, Tyler M Weaver, James Mills, Hyeon Kim, Lingyan Huang, Richard Owczarzy, Catherine A Musselman, Mark A Behlke, Bradley Ford, James O McNamara
Rapid and accurate bacterial detection methods are needed for clinical diagnostic, water, and food testing applications. The wide diversity of bacterial nucleases provides a rich source of enzymes that could be exploited as signal amplifying biomarkers to enable rapid, selective detection of bacterial species. With the exception of the use of micrococcal nuclease activity to detect Staphylococcus aureus, rapid methods that detect bacterial pathogens via their nuclease activities have not been developed. Here, we identify endonuclease I as a robust biomarker for E...
April 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28390962/in-vitro-activity-of-fosfomycin-trometamol-and-other-oral-antibiotics-against-multi-drug-resistant-uropathogens
#12
Maria Lina Mezzatesta, Giulia La Rosa, Gaetano Maugeri, Tiziana Zingali, Carla Caio, Andrea Novelli, Stefania Stefani
Clinical midstream and urinary catheter isolates (n=106) of extended-spectrum β-lactamase (ESBL)-positive Escherichia coli, carbapenemase-producing Klebsiella pneumoniae, Proteus mirabilis and meticillin-resistant Staphylococcus saprophyticus were tested against fosfomycin using the agar dilution method, the broth microdilution method and the gradient test described by the Clinical and Laboratory Standards Institute. Nitrofurantoin, co-trimoxazole, amoxicillin/clavulanic acid, cefuroxime, levofloxacin and ciprofloxacin were tested using the gradient test alone...
April 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28386705/a-new-concept-and-a-comprehensive-evaluation-of-sysmex-uf-1000i%C3%A2-flow-cytometer-to-identify-culture-negative-urine-specimens-in-patients-with-uti
#13
T Monsen, P Ryden
Urinary tract infections (UTIs) are among the most common bacterial infections in men and urine culture is gold standard for diagnosis. Considering the high prevalence of culture-negative specimens, any method that identifies such specimens is of interest. The aim was to evaluate a new screening concept for flow cytometry analysis (FCA). The outcomes were evaluated against urine culture, uropathogen species and three conventional screening methods. A prospective, consecutive study examined 1,312 urine specimens, collected during January and February 2012...
April 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28384863/comparative-evaluation-of-fosfomycin-activity-with-other-antimicrobial-agents-against-e-coli-isolates-from-urinary-tract-infections
#14
Ahmed Sardar, Sreekanth Reddy Basireddy, Anwar Navaz, Manisha Singh, Vasanti Kabra
INTRODUCTION: Fosfomycin is a broad spectrum anti-microbial agent with activity against various bacterial agents. It is a bactericidal antibiotic which interferes with cell wall synthesis. Fosfomycin is rapidly absorbed orally and majority of the drug is excreted unchanged in urine with very high concentration levels achieved in urine after a single oral dose. Urine levels remain high for prolonged period which makes it a suitable drug in the treatment of Urinary Tract Infections (UTI)...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28383394/methicillin-resistant-staphylococcus-aureus-as-a-uropathogen-in-an-irish-setting
#15
Aisling T Looney, Elaine J Redmond, Naomi M Davey, Padraig J Daly, Carole Troy, Brian F Carey, Ivor M Cullen
Urinary tract infections are one of the most common infectious diseases diagnosed in the community and in the hospital setting. Their treatment is complicated by drug-resistant pathogens and the colonization by microbes of indwelling urinary catheters. This study assessed the occurrence and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) uropathogens isolated for 5 consecutive years at University Hospital Waterford between 2010 and 2014. We created 4 clinically relevant subdivisions, based on urine source: hospital inpatients, patients from the Emergency Department, patients referred from their General Practitioner, and Nursing Home patients...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28379126/-community-acquired-urinary-tract-infections-in-older-adults
#16
Alberto Francisco Leoni, Aida Monterisi, Paula G Acuña
Background Community acquired urinary tract infections (caUTI) in adults are common ailments. Older adults are prone to infectious diseases, diagnosis can be difficult, their etiologic and antimicrobial resistance are poorly known. Objectives To evaluate the incidence discriminated by sex, symptoms, and to determine pathogens and their antimicrobial resistance rate. Methods A retrospective, descriptive and comparative study. We analyze uricultures among 2013 in the Hospital Nacional de Clinicas (Córdoba-Argentina)...
2017: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/28367473/the-inhibitory-effects-of-static-magnetic-field-on-escherichia-coli-from-two-different-sources-at-short-exposure-time
#17
Sofieh Mousavian-Roshanzamir, Ali Makhdoumi-Kakhki
This study was intended to investigate the effectiveness of static magnetic field on the growth of Escherichia coli (E. coli) provided from two sources, the urine samples of patients with urinary tract infections and the reference strain E. coli ATCC 25922. Bacterial samples in Nutrient Broth were subjected to a range of magnetic intensities (2, 4, 6, 9, 14, 16, 18, and 20 mT) at various exposure times (0, 15, 30, 45, 60, 75, and 90 min). The survival rate was measured in the presence and absence of the magnetic field over time...
April 2017: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28364867/preventing-urinary-tract-infections-after-menopause-without-antibiotics
#18
REVIEW
Marta Caretto, Andrea Giannini, Eleonora Russo, Tommaso Simoncini
Urinary tract infections (UTIs) are the most common bacterial infections in women, and increase in incidence after the menopause. It is important to uncover underlying abnormalities or modifiable risk factors. Several risk factors for recurrent UTIs have been identified, including the frequency of sexual intercourse, spermicide use and abnormal pelvic anatomy. In postmenopausal women UTIs often accompany the symptoms and signs of the genitourinary syndrome of menopause (GSM). Antimicrobial prophylaxis has been demonstrated to be effective in reducing the risk of recurrent UTIs in women, but this may lead to drug resistance of both the causative microorganisms and the indigenous flora...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28359738/development-of-a-multiplex-real-time-pcr-assay-for-phylogenetic-analysis-of-uropathogenic-escherichia-coli
#19
Mojtaba Hasanpour, Akram Najafi
Uropathogenic Escherichia coli (UPEC) is among major pathogens causing 80-90% of all episodes of urinary tract infections (UTIs). Recently, E. coli strains are divided into eight main phylogenetic groups including A, B1, B2, C, D, E, F, and clade I. This study was aimed to develop a rapid, sensitive, and specific multiplex real time PCR method capable of detecting phylogenetic groups of E. coli strains. This study was carried out on E. coli strains (isolated from the patient with UTI) in which the presence of all seven target genes had been confirmed in our previous phylogenetic study...
March 28, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28358889/transient-microbiota-exposures-activate-dormant-escherichia-coli-infection-in-the-bladder-and-drive-severe-outcomes-of-recurrent-disease
#20
Nicole M Gilbert, Valerie P O'Brien, Amanda L Lewis
Pathogens often inhabit the body asymptomatically, emerging to cause disease in response to unknown triggers. In the bladder, latent intracellular Escherichia coli reservoirs are regarded as likely origins of recurrent urinary tract infection (rUTI), a problem affecting millions of women worldwide. However, clinically plausible triggers that activate these reservoirs are unknown. Clinical studies suggest that the composition of a woman's vaginal microbiota influences her susceptibility to rUTI, but the mechanisms behind these associations are unclear...
March 2017: PLoS Pathogens
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