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JOURNAL ARTICLE
Miyo K Chatanaka, Lisa M Avery, Maria D Pasic, Shanthan Sithravadivel, Dalia Rotstein, Catherine Demos, Rachel Cohen, Taron Gorham, Mingyue Wang, Martin Stengelin, Anu Mathew, George Sigal, Jacob Wohlstadter, Ioannis Prassas, Eleftherios P Diamandis
BACKGROUND: Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) exhibit serum autoantibodies against aquaporin-4 (αAQP4) and myelin oligodendrocyte glycoprotein (αMOG). The variability of the autoantibody presentation warrants further research into subtyping each case. METHODS: To elucidate the relationship between astroglial and neuronal protein concentrations in the peripheral circulation with occurrence of these autoantibodies, 86 serum samples were analyzed using immunoassays...
April 5, 2024: Clinical Proteomics
#2
JOURNAL ARTICLE
Tomas Klail, Eike I Piechowiak, Nadja Krug, Christian Maegerlein, Volker Maus, Sebastian Fischer, Donald Lobsien, Daniel Pielenz, Hanna Styczen, Cornelius Deuschl, Maximilian Thormann, Elie Diamandis, Mirjam R Heldner, Johannes Kaesmacher, Pasquale Mordasini
BACKGROUND: Acute basilar artery occlusion (BAO) is a severe disease that is associated with an 85% mortality rate if untreated. Several studies have analyzed the use of mechanical thrombectomy (MT) in the different scenarios of BAO. However, the results remain conflicting and the role of MT as standard of care for vertebrobasilar tandem occlusions (VBTO) has not been confirmed. Our goal was to assess technical feasibility, safety, and functional outcome of endovascular treatment of VBTO in comparison to isolated BAO (IBAO)...
April 5, 2024: Interventional Neuroradiology
#3
JOURNAL ARTICLE
Julia A Diamandi, Julia C Duckhorn, Kara E Miller, Mason Weinstock, Sofia Leone, Micaela R Murphy, Troy R Shirangi
Most larval neurons in Drosophila are repurposed during metamorphosis for functions in adult life, but their contribution to the neural circuits for sexually dimorphic behaviors is unknown. Here, we identify two interneurons in the nerve cord of adult Drosophila females that control ovipositor extrusion, a courtship rejection behavior performed by mated females. We show that these two neurons are present in the nerve cord of larvae as mature, sexually monomorphic interneurons. During pupal development, they acquire the expression of the sexual differentiation gene, doublesex; undergo doublesex-dependent programmed cell death in males; and are remodeled in females for functions in female mating behavior...
February 10, 2024: Current Biology: CB
#4
JOURNAL ARTICLE
Miyo K Chatanaka, Ioannis Prassas, Eleftherios P Diamandis
In this commentary, we address a paper published by Johnson et al. by assessing the robustness of their method to discover diagnostic biomarkers in Alzheimer's disease (AD). In addition, we examine how these newly discovered and previously discovered biomarkers, can play a role in assisting patients with AD and those at risk for developing AD, with an emphasis on the translational hurdles that accompany such discoveries.
February 8, 2024: BMC Medicine
#5
JOURNAL ARTICLE
Ram Vasudevan Nampoothiri, Lisa Avery, Ivan Pasic, Ioannis Prassas, Eleftherios Diamandis, Fotios V Michelis
Introduction Despite well-established clinical criteria for diagnosis of SOS/VOD following allogeneic HCT, there is a lack of established diagnostic protein biomarkers. Methods Prospective samples were collected from patients with very severe SOS/VOD at diagnosis and days +3, +7, +14, and +30 post-initiation of defibrotide. Samples from age-matched controls with no VOD were collected at day +14, +30, +60, +90 and +180 following allogeneic HCT. Serum samples were analyzed for 2925 protein levels by antibody-based proximity extension assay (PEA)...
February 8, 2024: Acta Haematologica
#6
JOURNAL ARTICLE
Matthijs van der Meulen, Ronald C Ramos, Mathew R Voisin, Vikas Patil, Qingxia Wei, Olivia Singh, Seth A Climans, Navya Kalidindi, Rosemarylin Or, Ken Aldape, Phedias Diamandis, David G Munoz, Gelareh Zadeh, Warren P Mason
BACKGROUND: Patients with glioblastoma (GBM) have a median overall survival (OS) of approximately 16 months. However, approximately 5% of patients survive >5 years. This study examines the differences in methylation profiles between long-term survivors (>5 years, LTS) and short-term survivors (<1 year, STS) with isocitrate dehydrogenase (IDH)-wild-type GBMs. METHODS: In a multicenter retrospective analysis, we identified 25 LTS with a histologically confirmed GBM...
2024: Neuro-oncology advances
#7
JOURNAL ARTICLE
Chae Young Han, Jacob S Bedia, Wei-Lei Yang, Sarah J Hawley, Lindsay Bergan, Marika Hopper, Joseph Celestino, Jing Guo, Terrie G Gornet, Antoninus Soosaipillai, Hailing Yang, Samantha D Doskocil, Anna E Lokshin, Beverly C Handy, Eleftherios P Diamandis, Richard G Moore, Karen H Lu, Zhen Lu, Karen S Anderson, Charles W Drescher, Steven J Skates, Robert C Bast
BACKGROUND: Multiple antigens, autoantibodies (AAb), and antigen-autoantibody (Ag-AAb) complexes were compared for their ability to complement CA125 for early detection of ovarian cancer. METHODS: Twenty six biomarkers were measured in a single panel of sera from women with early stage (I-II) ovarian cancers (n = 64), late stage (III-IV) ovarian cancers (186), benign pelvic masses (200) and from healthy controls (502), and then split randomly (50:50) into a training set to identify the most promising classifier and a validation set to compare its performance to CA125 alone...
January 9, 2024: British Journal of Cancer
#8
JOURNAL ARTICLE
Donald Lobsien, Markus Holtmannspoetter, Florian Eff, Ansgar Berlis, Christoph Johannes Maurer, Daniel Behme, Elie Diamandis, Matthias Gawlitza, David Fiorella, Ciro Princiotta, Luigi Cirillo, Massimo Dall'Olio, Peter Keston, Joachim Klisch, Alberto Nania
BACKGROUND: Stent-assisted coiling (SAC) is a well-established method for treatment of wide-necked intracranial aneurysms. In this multicenter, retrospective case series we evaluated SAC with a new low-profile, laser-cut stent with an antithrombogenic hydrophilic polymer coating (pEGASUS-HPC) for the treatment of intracranial aneurysms. METHODS: Patients treated with pEGASUS-HPC SAC for one or more intracranial aneurysms were retrospectively included. Clinical, imaging, and procedural parameters as well as clinical and imaging follow-up data were recorded...
January 3, 2024: Journal of Neurointerventional Surgery
#9
Miyo K Chatanaka, Lisa M Avery, Maria D Pasic, Shanthan Sithravadivel, Dalia Rotstein, Catherine Demos, Rachel Cohen, Taron Gorham, Mingyue Wang, Martin Stengelin, Anu Mathew, Jacob Wohlstadter, Ioannis Prassas, Eleftherios P Diamandis
Background Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) exhibit serum autoantibodies against aquaporin-4 (αAQP4) and myelin oligodendrocyte glycoprotein (αMOG). The variability of the autoantibody presentation warrants further research into subtyping each case. Methods To elucidate the relationship between astroglial and neuronal protein concentrations in the peripheral circulation with occurrence of these autoantibodies, 86 serum samples were analyzed using immunoassays...
November 29, 2023: Research Square
#10
JOURNAL ARTICLE
Eleftherios P Diamandis
No abstract text is available yet for this article.
October 2023: EJIFCC
#11
REVIEW
Arsani Yousef, Lucianna Ghobrial, Eleftherios P Diamandis
Differences in tumors related to location, tissue type, and histological subtype have been well documented for decades. Tumors are also molecularly very diverse. In this short review we describe the current classification schemes for tumor heterogeneity. We enlist the various drivers of tumor heterogeneity generation and comment on their clinical significance. New molecular techniques promise to assess tumor heterogeneity at affordable cost, so that these techniques can soon enter the clinic. While tumor heterogeneity currently represents a major unfavorable barrier in the field of oncology, it may also be a key in revolutionizing cancer diagnosis and treatment...
October 12, 2023: Diagnosis
#12
JOURNAL ARTICLE
Anglin Dent, Kevin Faust, K H Brian Lam, Narges Alhangari, Alberto J Leon, Queenie Tsang, Zaid Saeed Kamil, Andrew Gao, Prodipto Pal, Stephanie Lheureux, Amit Oza, Phedias Diamandis
Intratumoral heterogeneity can wreak havoc on current precision medicine strategies because of challenges in sufficient sampling of geographically separated areas of biodiversity distributed across centimeter-scale tumor distances. To address this gap, we developed a deep learning pipeline that leverages histomorphologic fingerprints of tissue to create "Histomic Atlases of Variation Of Cancers" (HAVOC). Using a number of objective molecular readouts, we demonstrate that HAVOC can define regional cancer boundaries with distinct biology...
September 29, 2023: Science Advances
#13
JOURNAL ARTICLE
Dorsa Sohaei, Simon Thebault, Lisa M Avery, Ihor Batruch, Brian Lam, Wei Xu, Rubah S Saadeh, Isobel A Scarisbrick, Eleftherios P Diamandis, Ioannis Prassas, Mark S Freedman
BACKGROUND: Multiple sclerosis (MS) remains a highly unpredictable disease. Many hope that fluid biomarkers may contribute to better stratification of disease, aiding the personalisation of treatment decisions, ultimately improving patient outcomes. OBJECTIVE: The objective of this study was to evaluate the predictive value of CSF brain-specific proteins from early in the disease course of MS on long term clinical outcomes. METHODS: In this study, 34 MS patients had their CSF collected and stored within 5 years of disease onset and were then followed clinically for at least 15 years...
August 29, 2023: Clinical Proteomics
#14
JOURNAL ARTICLE
Rifat Shahriar Sajid, Lennart J van Winden, Phedias Diamandis
Glioblastoma (GBM) is the most common and severe form of brain cancer among adults. Its aggressiveness is largely attributed to its complex and heterogeneous biology that despite maximal surgery and multimodal chemoradiation treatment, inevitably recurs. Traditional large-scale profiling approaches have contributed substantially to the understanding of patient-to-patient inter-tumoral differences in GBM. However, it is now clear that biological differences within an individual (intra-tumoral heterogeneity) are also a prominent factor in treatment resistance and recurrence of GBM and will likely require integration of data from multiple recently developed omics platforms to fully unravel...
July 24, 2023: Proteomics
#15
REVIEW
Richard James Sugden, Viet-Linh Luke Pham-Kim-Nghiem-Phu, Ingrid Campbell, Alberto Leon, Phedias Diamandis
Collection of electroencephalographic (EEG) data provides an opportunity to non-invasively study human brain plasticity, learning and the evolution of various neuropsychiatric disorders. Traditionally, due to sophisticated hardware, EEG studies have been largely limited to research centers which restrict both testing contexts and repeated longitudinal measures. The emergence of low-cost "wearable" EEG devices now provides the prospect of frequent and remote monitoring of the human brain for a variety of physiological and pathological brain states...
June 21, 2023: Bioelectronic Medicine
#16
REVIEW
Sok-Ja Janket, Douglas D Fraser, Alison E Baird, Faleh Tamimi, Dorsa Sohaei, Harry A Conte, Ioannis Prassas, Eleftherios P Diamandis
The most prevalent symptoms of post-COVID-19 condition are pulmonary dysfunction, fatigue and muscle weakness, anxiety, anosmia, dysgeusia, headaches, difficulty in concentrating, sexual dysfunction, and digestive disturbances. Hence, neurological dysfunction and autonomic impairments predominate in post-COVID-19 condition. Tachykinins including the most studied substance P are neuropeptides expressed throughout the nervous and immune systems, and contribute to many physiopathological processes in the nervous, immune, gastrointestinal, respiratory, urogenital, and dermal systems and participate in inflammation, nociception, and cell proliferation...
June 13, 2023: The Lancet. Microbe
#17
JOURNAL ARTICLE
Silvia Crescioli, Isabel Correa, Joseph Ng, Zena N Willsmore, Roman Laddach, Alicia Chenoweth, Jitesh Chauhan, Ashley Di Meo, Alexander Stewart, Eleni Kalliolia, Elena Alberts, Rebecca Adams, Robert J Harris, Silvia Mele, Giulia Pellizzari, Anna B M Black, Heather J Bax, Anthony Cheung, Mano Nakamura, Ricarda M Hoffmann, Manuela Terranova-Barberio, Niwa Ali, Ihor Batruch, Antoninus Soosaipillai, Ioannis Prassas, Antigona Ulndreaj, Miyo K Chatanaka, Rosamund Nuamah, Shichina Kannambath, Pawan Dhami, Jenny L C Geh, Alastair D MacKenzie Ross, Ciaran Healy, Anita Grigoriadis, David Kipling, Panagiotis Karagiannis, Deborah K Dunn-Walters, Eleftherios P Diamandis, Sophia Tsoka, James Spicer, Katie E Lacy, Franca Fraternali, Sophia N Karagiannis
B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been characterized in these cancers to detail. Here we show comprehensive phenotyping in samples of circulating and tumor-resident B cells as well as serum antibodies in melanoma patients. Memory B cells are enriched in tumors compared to blood in paired samples and feature distinct antibody repertoires, linked to specific isotypes. Tumor-associated B cells undergo clonal expansion, class switch recombination, somatic hypermutation and receptor revision...
June 8, 2023: Nature Communications
#18
JOURNAL ARTICLE
Timo-Pekka K Lehto, Ruusu-Maaria Kovanen, Susanna Lintula, Adrian Malén, Carolin Stürenberg, Andrew Erickson, Olli-Pekka Pulkka, Ulf-Håkan Stenman, Eleftherios P Diamandis, Antti Rannikko, Tuomas Mirtti, Hannu Koistinen
We aimed to study mRNA levels and prognostic impact of all 15 human kallikrein-related peptidases (KLKs) and their targets, proteinase-activated receptors (PARs), in surgically treated prostate cancer (PCa). Seventy-nine patients with localized grade group 2-4 PCas represented aggressive cases, based on metastatic progression during median follow-up of 11 years. Eighty-six patients with similar baseline characteristics, but no metastasis during follow-up, were assigned as controls. Transcript counts were detected with nCounter technology...
May 4, 2023: International Journal of Cancer. Journal International du Cancer
#19
JOURNAL ARTICLE
Eleftherios P Diamandis
The revolution in electronic publishing now allows for papers to be continuously critiqued through letters to the editor, online comments, tweets and other means. However, established top-ranked journals still pose serious barriers regarding cultivation, documentation and dissemination of post publication critiques (1). To improve on this situation, Hardwicke et al. published a set of rules, one being for journals to actively encourage and highlight post publication critique to their readership. In this commentary, I present a case whereby the editors of a top ranked journal hindered the discussion/debate between authors and expert readers...
April 2023: EJIFCC
#20
Stephanie D Williams, Beverly Setzer, Nina E Fultz, Zenia Valdiviezo, Nicole Tacugue, Zachary Diamandis, Laura D Lewis
[This corrects the article DOI: 10.1371/journal.pbio.3002035.].
April 2023: PLoS Biology
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