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Paolo Zaffino, Delia Ciardo, Patrik Raudaschl, Karl Fritscher, Rosalinda Ricotti, Daniela Alterio, Giulia Marvaso, Cristiana Fodor, Guido Baroni, Francesco Amato, Roberto Orecchia, Barbara Alicja Jereczek-Fossa, Gregory C Sharp, Maria Francesca Spadea
Multi Atlas Based Segmentation (MABS) uses a database of atlas images, and an atlas selection process is used to choose an atlas subset for registration and voting. In the current state of the art, atlases are chosen according to a similarity criterion between the target subject and each atlas in the database. In this paper, we propose a new concept for atlas selection that relies on selecting the best performing group of atlases rather than the group of highest scoring individual atlases.
 Experiments were performed using CT images of 50 patients, with contours of brainstem and parotid glands...
May 22, 2018: Physics in Medicine and Biology
Kristoffer H Hellton, Nils Lid Hjort
Statistical prediction methods typically require some form of fine-tuning of tuning parameter(s), with K-fold cross-validation as the canonical procedure. For ridge regression, there exist numerous procedures, but common for all, including cross-validation, is that one single parameter is chosen for all future predictions. We propose instead to calculate a unique tuning parameter for each individual for which we wish to predict an outcome. This generates an individualized prediction by focusing on the vector of covariates of a specific individual...
April 15, 2018: Statistics in Medicine
Ying-Hao Lu, Li-Yao Lee, Ying-Lan Chen, Hsing-I Cheng, Wen-Tsung Tsai, Chen-Chun Kuo, Chung-Yu Chen, Yaw-Bin Huang
We selected iOS in this study as the App operation system, Objective-C as the programming language, and Oracle as the database to develop an App to inspect controlled substances in patient care units. Using a web-enabled smartphone, pharmacist inspection can be performed on site and the inspection result can be directly recorded into HIS through the Internet, so human error of data translation can be minimized and the work efficiency and data processing can be improved. This system not only is fast and convenient compared to the conventional paperwork, but also provides data security and accuracy...
2017: BioMed Research International
Reza Zarei, Alex Kuo
We analyzed, designed and deployed a web-based, self-monitoring system to support wellness coaching. A wellness coach can plan for clients' exercise and diet through the system and is able to monitor the changes in body dimensions and body composition that the client reports. The system can also visualize the client's data in form of graphs for both the client and the coach. Both parties can also communicate through the messaging feature embedded in the application. A reminder system is also incorporated into the system and sends reminder messages to the clients when their reporting is due...
2017: Studies in Health Technology and Informatics
Elham Haem, Kajsa Harling, Seyyed Mohammad Taghi Ayatollahi, Najaf Zare, Mats O Karlsson
One important aim in population pharmacokinetics (PK) and pharmacodynamics is identification and quantification of the relationships between the parameters and covariates. Lasso has been suggested as a technique for simultaneous estimation and covariate selection. In linear regression, it has been shown that Lasso possesses no oracle properties, which means it asymptotically performs as though the true underlying model was given in advance. Adaptive Lasso (ALasso) with appropriate initial weights is claimed to possess oracle properties; however, it can lead to poor predictive performance when there is multicollinearity between covariates...
February 2017: Journal of Pharmacokinetics and Pharmacodynamics
Zahra Anita Trippe, Bruno Brendani, Christoph Meier, David Lewis
INTRODUCTION: The distribution and use of substandard medicines (SSMs) is a public health concern worldwide. The detection of SSMs is currently limited to expensive large-scale assay techniques such as high-performance liquid chromatography (HPLC). Since 2013, the Pharmacovigilance Department at Novartis Pharma AG has been analyzing drug-associated adverse events related to 'product quality issues' with the aim of detecting defective medicines using spontaneous reporting. The method of identifying SSMs with spontaneous reporting was pioneered by the Monitoring Medicines project in 2011...
April 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Arnold van Huis
BACKGROUND: The number of termite species in the world is more than 2500, and Africa with more than 1000 species has the richest intercontinental diversity. The family Termitidae contains builders of great mounds up to 5 m high. Colonies are composed of casts: a queen, a king, soldiers and workers. Some species of termite cultivate specialised fungi to digest cellulose. Termites constitute 10% of all animal biomass in the tropics. The purpose of the study was to make an overview of how termites are utilized, perceived and experienced in daily life across sub-Saharan Africa...
January 26, 2017: Journal of Ethnobiology and Ethnomedicine
Barbara Anna Danek, Aris Karatasakis, Judit Karacsonyi, Aya Alame, Erica Resendes, Pratik Kalsaria, Phuong-Khanh J Nguyen-Trong, Bavana V Rangan, Michele Roesle, Shuaib Abdullah, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Coronary lipid core plaque may be associated with the incidence of subsequent cardiovascular events. METHODS: We analyzed outcomes of 239 patients who underwent near-infrared spectroscopy (NIRS) coronary imaging between 2009-2011. Multivariable Cox regression was used to identify variables independently associated with the incidence of major adverse cardiovascular events (MACE; cardiac mortality, acute coronary syndromes (ACS), stroke, and unplanned revascularization) during follow-up...
April 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Charlène Guillaumot, Alexis Martin, Salomé Fabri-Ruiz, Marc Eléaume, Thomas Saucède
The present dataset provides a case study for species distribution modelling (SDM) and for model testing in a poorly documented marine region. The dataset includes spatially-explicit data for echinoid (Echinodermata: Echinoidea) distribution. Echinoids were collected during oceanographic campaigns led around the Kerguelen Plateau (+63°/+81°E; -46°/-56°S) since 1872. In addition to the identification of collection specimens from historical cruises, original data from the recent campaigns POKER II (2010) and PROTEKER 2 to 4 (2013-2015) are also provided...
2016: ZooKeys
A G K McNair, N Heywood, J Tiernan, A Verjee, S P Bach, N S Fearnhead
AIM: There is a recognized need to include the views of patients and the public in prioritizing health research. This study aimed: (i) to explore patients' views on colorectal research; and (ii) to prioritize research topics with patients and the public. METHOD: In phase 1, 12 charitable organizations and patient groups with an interest in bowel disease were invited to attend a consultation exercise. Participants were briefed on 25 colorectal research topics prioritized by members of the Association of Coloproctology of Great Britain and Ireland...
January 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Barbara A Danek, Aris Karatasakis, Aya J Alame, Phuong-Khanh J Nguyen-Trong, Judit Karacsonyi, Bavana Rangan, Michele Roesle, Amy Atwell, Erica Resendes, Jose Roberto Martinez-Parachini, Rahel Iwnetu, Pratik Kalsaria, Furqan Siddiqui, James E Muller, Subhash Banerjee, Emmanouil Brilakis
OBJECTIVES: We sought to examine near-infrared spectroscopy (NIRS) imaging findings of aortocoronary saphenous vein grafts (SVGs). BACKGROUND: SVGs are prone to develop atherosclerosis similar to native coronary arteries. They have received little study using NIRS. METHODS: We examined the clinical characteristics and imaging findings from 43 patients who underwent NIRS imaging of 45 SVGs at our institution between 2009 and 2016. RESULTS: The mean patient age was 67 ± 7 years and 98% were men, with high prevalence of diabetes mellitus (56%), hypertension (95%), and dyslipidemia (95%)...
May 2017: Catheterization and Cardiovascular Interventions
Neil Marlow, Hannah Bower, David Jones, Peter Brocklehurst, Sara Kenyon, Katie Pike, David Taylor, Alison Salt
BACKGROUND: Antibiotics used for women in spontaneous preterm labour without overt infection, in contrast to those with preterm rupture of membranes, are associated with altered functional outcomes in their children. METHODS: From the National Pupil Database, we used Key Stage 2 scores, national test scores in school year 6 at 11 years of age, to explore the hypothesis that erythromycin and co-amoxiclav were associated with poorer educational outcomes within the ORACLE Children Study...
March 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
Donato F Altomare
No abstract text is available yet for this article.
December 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Chien-Min Chen, I-Ching Hou, Hsiao-Ping Chen, Yung-Ching Weng
The integrity of electronic nursing records (ENRs) stands for the quality of medical records. But patients' conditions are varied (e.g. not every patient had wound or need fall prevention), to achieve the integrity of ENRs depends much on clinical nurses' attention. Our study site, an one 2,300-bed hospital in northern Taiwan, there are a total of 20 ENRs including nursing assessments, nursing care plan, discharge planning etc. implemented in the whole hospital before 2014. It become important to help clinical nurses to decrease their human recall burden to complete these records...
2016: Studies in Health Technology and Informatics
Isabel Beichl, Stephen S Bullock, Daegene Song
We consider an arbitrary mapping f: {0, …, N - 1} → {0, …, N - 1} for N = 2 (n) , n some number of quantum bits. Using N calls to a classical oracle evaluating f(x) and an N-bit memory, it is possible to determine whether f(x) is one-to-one. For some radian angle 0 ≤ θ ≤ π/2, we say f(x) is θ - concentrated if and only if [Formula: see text] for some given ψ 0 and any 0 ≤ x ≤ N - 1. We present a quantum algorithm that distinguishes a θ-concentrated f(x) from a one-to-one f(x) in O(1) calls to a quantum oracle function Uf with high probability...
November 2007: Journal of Research of the National Institute of Standards and Technology
Jennifer A Sinnott, Tianxi Cai
When a moderate number of potential predictors are available and a survival model is fit with regularization to achieve variable selection, providing accurate inference on the predicted survival can be challenging. We investigate inference on the predicted survival estimated after fitting a Cox model under regularization guaranteeing the oracle property. We demonstrate that existing asymptotic formulas for the standard errors of the coefficients tend to underestimate the variability for some coefficients, while typical resampling such as the bootstrap tends to overestimate it; these approaches can both lead to inaccurate variance estimation for predicted survival functions...
October 2016: Biostatistics
Zhicong Qiu, David J Miller, George Kesidis
We investigate semisupervised learning (SL) and pool-based active learning (AL) of a classifier for domains with label-scarce (LS) and unknown categories, i.e., defined categories for which there are initially no labeled examples. This scenario manifests, e.g., when a category is rare, or expensive to label. There are several learning issues when there are unknown categories: 1) it is a priori unknown which subset of (possibly many) measured features are needed to discriminate unknown from common classes and 2) label scarcity suggests that overtraining is a concern...
April 2017: IEEE Transactions on Neural Networks and Learning Systems
D Stanekova, M Mirandola, L Gios, C Botsi, M Habekova, V Gonzales-Soler, G K Nikolopoulos
OBJECTIVES: The aim of our study was to validate the Genscreen HIV ½ version 2 (BIO-RAD) for detecting HIV antibodies in oral fluid specimens (OF). BACKGROUND: The advantage of assays to detect HIV infection in OF lies in the on-site easy access and noninvasive sample collection. METHODS: Paired serum and OF were collected from 496 subjects (263 HIV-positive and 233 HIV-negative) using the Oracol test kit (Oracle Diagnostics, Inc). The quality of OF was verified by measuring total IgGs using the Human IgG ELISA Quantitation Kit (Bethyl Lab...
2016: Bratislavské Lekárske Listy
Steve R Makkar, Tari Turner, Anna Williamson, Jordan Louviere, Sally Redman, Abby Haynes, Sally Green, Sue Brennan
BACKGROUND: Evidence-informed policymaking is more likely if organisations have cultures that promote research use and invest in resources that facilitate staff engagement with research. Measures of organisations' research use culture and capacity are needed to assess current capacity, identify opportunities for improvement, and examine the impact of capacity-building interventions. The aim of the current study was to develop a comprehensive system to measure and score organisations' capacity to engage with and use research in policymaking, which we entitled ORACLe (Organisational Research Access, Culture, and Leadership)...
January 14, 2016: Health Research Policy and Systems
Stephen Honeybul, Kwok M Ho, David W Blacker
BACKGROUND: There continues to be considerable interest in the use of decompressive hemicraniectomy in the management of malignant cerebral artery infarction; however, concerns remain about long-term outcome. OBJECTIVE: To assess opinion on consent and acceptable outcome among a wide range of healthcare workers. METHODS: Seven hundred seventy-three healthcare workers at the 2 major public neurosurgical centers in Western Australia participated...
August 2016: Neurosurgery
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