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Barbara Anna Danek, Aris Karatasakis, Judit Karacsonyi, Aya Alame, Erica Resendes, Pratik Kalsaria, Phuong-Khanh J Nguyen-Trong, Bavana V Rangan, Michele Roesle, Shuaib Abdullah, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Coronary lipid core plaque may be associated with the incidence of subsequent cardiovascular events. METHODS: We analyzed outcomes of 239 patients who underwent near-infrared spectroscopy (NIRS) coronary imaging between 2009-2011. Multivariable Cox regression was used to identify variables independently associated with the incidence of major adverse cardiovascular events (MACE; cardiac mortality, acute coronary syndromes (ACS), stroke, and unplanned revascularization) during follow-up...
December 15, 2016: Cardiovascular Revascularization Medicine: Including Molecular Interventions
Charlène Guillaumot, Alexis Martin, Salomé Fabri-Ruiz, Marc Eléaume, Thomas Saucède
The present dataset provides a case study for species distribution modelling (SDM) and for model testing in a poorly documented marine region. The dataset includes spatially-explicit data for echinoid (Echinodermata: Echinoidea) distribution. Echinoids were collected during oceanographic campaigns led around the Kerguelen Plateau (+63°/+81°E; -46°/-56°S) since 1872. In addition to the identification of collection specimens from historical cruises, original data from the recent campaigns POKER II (2010) and PROTEKER 2 to 4 (2013-2015) are also provided...
2016: ZooKeys
A G K McNair, N Heywood, J Tiernan, A Verjee, S P Bach, N S Fearnhead
AIM: There is a recognised need to include the views of patients and the public in prioritising health research. This study aimed 1) to explore patients' views on colorectal research and 2) to prioritise research topics with patients and the public. METHOD: In phase 1, twelve charitable organisations and patient groups with an interest in bowel disease were invited to attend a consultation exercise. Participants were briefed on 25 colorectal research topics prioritised by members of the Association of Coloproctology of Great Britain and Ireland...
November 21, 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Barbara A Danek, Aris Karatasakis, Aya J Alame, Phuong-Khanh J Nguyen-Trong, Judit Karacsonyi, Bavana Rangan, Michele Roesle, Amy Atwell, Erica Resendes, Jose Roberto Martinez-Parachini, Rahel Iwnetu, Pratik Kalsaria, Furqan Siddiqui, James E Muller, Subhash Banerjee, Emmanouil Brilakis
OBJECTIVES: We sought to examine near-infrared spectroscopy (NIRS) imaging findings of aortocoronary saphenous vein grafts (SVGs). BACKGROUND: SVGs are prone to develop atherosclerosis similar to native coronary arteries. They have received little study using NIRS. METHODS: We examined the clinical characteristics and imaging findings from 43 patients who underwent NIRS imaging of 45 SVGs at our institution between 2009 and 2016. RESULTS: The mean patient age was 67 ± 7 years and 98% were men, with high prevalence of diabetes mellitus (56%), hypertension (95%), and dyslipidemia (95%)...
August 18, 2016: Catheterization and Cardiovascular Interventions
Neil Marlow, Hannah Bower, David Jones, Peter Brocklehurst, Sara Kenyon, Katie Pike, David Taylor, Alison Salt
BACKGROUND: Antibiotics used for women in spontaneous preterm labour without overt infection, in contrast to those with preterm rupture of membranes, are associated with altered functional outcomes in their children. METHODS: From the National Pupil Database, we used Key Stage 2 scores, national test scores in school year 6 at 11 years of age, to explore the hypothesis that erythromycin and co-amoxiclav were associated with poorer educational outcomes within the ORACLE Children Study...
August 11, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
Donato F Altomare
No abstract text is available yet for this article.
December 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Chien-Min Chen, I-Ching Hou, Hsiao-Ping Chen, Yung-Ching Weng
The integrity of electronic nursing records (ENRs) stands for the quality of medical records. But patients' conditions are varied (e.g. not every patient had wound or need fall prevention), to achieve the integrity of ENRs depends much on clinical nurses' attention. Our study site, an one 2,300-bed hospital in northern Taiwan, there are a total of 20 ENRs including nursing assessments, nursing care plan, discharge planning etc. implemented in the whole hospital before 2014. It become important to help clinical nurses to decrease their human recall burden to complete these records...
2016: Studies in Health Technology and Informatics
Isabel Beichl, Stephen S Bullock, Daegene Song
We consider an arbitrary mapping f: {0, …, N - 1} → {0, …, N - 1} for N = 2 (n) , n some number of quantum bits. Using N calls to a classical oracle evaluating f(x) and an N-bit memory, it is possible to determine whether f(x) is one-to-one. For some radian angle 0 ≤ θ ≤ π/2, we say f(x) is θ - concentrated if and only if [Formula: see text] for some given ψ 0 and any 0 ≤ x ≤ N - 1. We present a quantum algorithm that distinguishes a θ-concentrated f(x) from a one-to-one f(x) in O(1) calls to a quantum oracle function Uf with high probability...
November 2007: Journal of Research of the National Institute of Standards and Technology
Jennifer A Sinnott, Tianxi Cai
When a moderate number of potential predictors are available and a survival model is fit with regularization to achieve variable selection, providing accurate inference on the predicted survival can be challenging. We investigate inference on the predicted survival estimated after fitting a Cox model under regularization guaranteeing the oracle property. We demonstrate that existing asymptotic formulas for the standard errors of the coefficients tend to underestimate the variability for some coefficients, while typical resampling such as the bootstrap tends to overestimate it; these approaches can both lead to inaccurate variance estimation for predicted survival functions...
October 2016: Biostatistics
Zhicong Qiu, David J Miller, George Kesidis
We investigate semisupervised learning (SL) and pool-based active learning (AL) of a classifier for domains with label-scarce (LS) and unknown categories, i.e., defined categories for which there are initially no labeled examples. This scenario manifests, e.g., when a category is rare, or expensive to label. There are several learning issues when there are unknown categories: 1) it is a priori unknown which subset of (possibly many) measured features are needed to discriminate unknown from common classes and 2) label scarcity suggests that overtraining is a concern...
January 26, 2016: IEEE Transactions on Neural Networks and Learning Systems
D Stanekova, M Mirandola, L Gios, C Botsi, M Habekova, V Gonzales-Soler, G K Nikolopoulos
OBJECTIVES: The aim of our study was to validate the Genscreen HIV ½ version 2 (BIO-RAD) for detecting HIV antibodies in oral fluid specimens (OF). BACKGROUND: The advantage of assays to detect HIV infection in OF lies in the on-site easy access and noninvasive sample collection. METHODS: Paired serum and OF were collected from 496 subjects (263 HIV-positive and 233 HIV-negative) using the Oracol test kit (Oracle Diagnostics, Inc). The quality of OF was verified by measuring total IgGs using the Human IgG ELISA Quantitation Kit (Bethyl Lab...
2016: Bratislavské Lekárske Listy
Steve R Makkar, Tari Turner, Anna Williamson, Jordan Louviere, Sally Redman, Abby Haynes, Sally Green, Sue Brennan
BACKGROUND: Evidence-informed policymaking is more likely if organisations have cultures that promote research use and invest in resources that facilitate staff engagement with research. Measures of organisations' research use culture and capacity are needed to assess current capacity, identify opportunities for improvement, and examine the impact of capacity-building interventions. The aim of the current study was to develop a comprehensive system to measure and score organisations' capacity to engage with and use research in policymaking, which we entitled ORACLe (Organisational Research Access, Culture, and Leadership)...
January 14, 2016: Health Research Policy and Systems
Stephen Honeybul, Kwok M Ho, David W Blacker
BACKGROUND: There continues to be considerable interest in the use of decompressive hemicraniectomy in the management of malignant cerebral artery infarction; however, concerns remain about long-term outcome. OBJECTIVE: To assess opinion on consent and acceptable outcome among a wide range of healthcare workers. METHODS: Seven hundred seventy-three healthcare workers at the 2 major public neurosurgical centers in Western Australia participated...
August 2016: Neurosurgery
Julia Pakpoor, Giulio Disanto, Daniel R Altmann, Sue Pavitt, Benjamin P Turner, Monica Marta, Gunnar Juliusson, David Baker, Jeremy Chataway, Klaus Schmierer
OBJECTIVE: To compare the cancer risk of cladribine and other disease-modifying drugs (DMDs) in trials of people with relapsing multiple sclerosis (pwRMS). METHODS: Meta-analysis of phase III trials of licensed DMDs for pwRMS and a phase III trial of cladribine (CLARITY). Cancer rates were compared using Fisher exact test. RESULTS: Eleven trials were included. Investigated treatments included cladribine, dimethyl fumarate, fingolimod, teriflunomide, natalizumab, alemtuzumab, and glatiramer acetate...
December 2015: Neurology® Neuroimmunology & Neuroinflammation
Maria R Silva, Ana Alarcão, Teresa Ferreira, Maria d'Aguiar, Ana Ladeirinha, Sandra Balseiro, Lina Carvalho
PURPOSE: The use of trastuzumab (Herceptin) to target HER2 has been applied in breast carcinoma and gastric carcinoma (GC). Previous studies have tested trastuzumab's effectiveness by assessing HER2 expression or HER2 amplification by means of immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH). In this work we aimed to evaluate automated FISH and IHC technologies for HER2 detection in GC biopsies to be used in routine pathology practice. METHODS: The study used an Oracle HER2 IHC System and an LSI HER2/CEP17 Dual Probe on an automated Bond system (Leica Microsystems)...
February 28, 2016: International Journal of Biological Markers
W Scott Campbell, Jay Pedersen, James C McClay, Praveen Rao, Dhundy Bastola, James R Campbell
OBJECTIVE: SNOMED CT is the international lingua franca of terminologies for human health. Based in Description Logics (DL), the terminology enables data queries that incorporate inferences between data elements, as well as, those relationships that are explicitly stated. However, the ontologic and polyhierarchical nature of the SNOMED CT concept model make it difficult to implement in its entirety within electronic health record systems that largely employ object oriented or relational database architectures...
October 2015: Journal of Biomedical Informatics
Fahad Shahbaz Khan, Jiaolong Xu, Joost van de Weijer, Andrew D Bagdanov, Rao Muhammad Anwer, Antonio M Lopez
Action recognition in still images is a challenging problem in computer vision. To facilitate comparative evaluation independently of person detection, the standard evaluation protocol for action recognition uses an oracle person detector to obtain perfect bounding box information at both training and test time. The assumption is that, in practice, a general person detector will provide candidate bounding boxes for action recognition. In this paper, we argue that this paradigm is suboptimal and that action class labels should already be considered during the detection stage...
November 2015: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Ashok Kumar Das, Vanga Odelu, Adrijit Goswami
The telecare medicine information system (TMIS) helps the patients to gain the health monitoring facility at home and access medical services over the Internet of mobile networks. Recently, Amin and Biswas presented a smart card based user authentication and key agreement security protocol usable for TMIS system using the cryptographic one-way hash function and biohashing function, and claimed that their scheme is secure against all possible attacks. Though their scheme is efficient due to usage of one-way hash function, we show that their scheme has several security pitfalls and design flaws, such as (1) it fails to protect privileged-insider attack, (2) it fails to protect strong replay attack, (3) it fails to protect strong man-in-the-middle attack, (4) it has design flaw in user registration phase, (5) it has design flaw in login phase, (6) it has design flaw in password change phase, (7) it lacks of supporting biometric update phase, and (8) it has flaws in formal security analysis...
September 2015: Journal of Medical Systems
Iván Díaz, Alan Hubbard, Anna Decker, Mitchell Cohen
We present prediction and variable importance (VIM) methods for longitudinal data sets containing continuous and binary exposures subject to missingness. We demonstrate the use of these methods for prognosis of medical outcomes of severe trauma patients, a field in which current medical practice involves rules of thumb and scoring methods that only use a few variables and ignore the dynamic and high-dimensional nature of trauma recovery. Well-principled prediction and VIM methods can provide a tool to make care decisions informed by the high-dimensional patient's physiological and clinical history...
2015: PloS One
Wilhelmine Hadler Meeraus, Irene Petersen, Ruth Gilbert
BACKGROUND: Between 19%-44% pregnant women are prescribed antibiotics during pregnancy. A single, large randomised-controlled-trial (ORACLE Childhood Study II) found an increased risk of childhood cerebral palsy and possibly epilepsy following prophylactic antibiotic use in pregnant women with spontaneous preterm labour. We ascertained whether this outcome could be reproduced across the population of babies delivered at term and prospectively followed in primary-care using data from The Health Improvement Network...
2015: PloS One
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