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https://www.readbyqxmd.com/read/29782139/obstetric-outcomes-after-fresh-versus-frozen-thawed-embryo-transfers-a-systematic-review-and-meta-analysis
#1
Matheus Roque, Marcello Valle, Marcos Sampaio, Selmo Geber
OBJECTIVE: To evaluate if there are differences in the risks of obstetric outcomes in IVF/ICSI singleton pregnancies when compared fresh to frozen-thawed embryo transfers (FET). METHODS: This was a systematic review and meta-analysis evaluating the obstetric outcomes in singleton pregnancies after FET and fresh embryo transfer. The outcomes included in this study were pregnancy-induced hypertension (PIH), pre-eclampsia, placenta previa, and placenta accreta. RESULTS: The search yielded 654 papers, 6 of which met the inclusion criteria and reported on obstetric outcomes...
May 21, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29778554/cumulative-live-birth-rates-after-ivf-in-patients-with-polycystic-ovaries-phenotype-matters
#2
Michel De Vos, Stéphanie Pareyn, Panagiotis Drakopoulos, José M Raimundo, Ellen Anckaert, Samuel Santos-Ribeiro, Nikolaos P Polyzos, Herman Tournaye, Christophe Blockeel
RESEARCH QUESTION: Do cumulative live birth rates (CLBR) vary among women with different polycystic ovary syndrome (PCOS) phenotypes who undergo IVF/intracytoplasmic sperm injection (ICSI) treatment? DESIGN: In this retrospective cohort study, data from 567 patients undergoing an assisted reproductive technology (ART) cycle between January 2010 and December 2015 were collected. Demographical traits, cycle characteristics and clinical and laboratory data were analysed...
May 7, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29778384/association-of-birth-defects-with-the-mode-of-assisted-reproductive-technology-in-a-chinese-data-linkage-cohort
#3
Hui-Ting Yu, Qing Yang, Xiao-Xi Sun, Guo-Wu Chen, Nai-Si Qian, Ren-Zhi Cai, Han-Bing Guo, Chun-Fang Wang
OBJECTIVE: To evaluate the impact of assisted reproductive technology (ART) on the offspring of Chinese population. DESIGN: Retrospective, data-linkage cohort. SETTING: Not applicable. PATIENT(S): Live births resulting from ART or natural conception. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Birth defects coded according to ICD-10. RESULT(S): Births after ART were more likely to be female and multiple births, especially after intracytoplasmic sperm injection (ICSI)...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29775803/assisted-reproductive-technologies-and-imprinting-disorders-results-of-a-study-from-a-french-congenital-malformations-registry
#4
Audrey Uk, Sophie Collardeau-Frachon, Quentin Scanvion, Lucas Michon, Emmanuelle Amar
INTRODUCTION: Assisted Reproductive Technologies (ART) is increasingly used to help infertile couples to have children around the world. A number of studies have been published reporting an increased risk of major malformations in children born following ART, especially an increased incidence of epigenetic diseases (ED). This study aimed to assess the incidence of epigenetic diseases with affected imprinting genes in infants or children from pregnancies obtained through IVF/ICSI compared to infants or children from pregnancies obtained spontaneously...
May 15, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29768247/oocyte-triggering-day-progesterone-levels-and-endometrial-appearance-in-normoresponders-undergoing-ivf-icsi-cycles-a-hypothesis-and-a-study-protocol
#5
Charalampos Siristatidis, Panagiotis Drakopoulos, Paraskevi Vogiatzi, Vasilios Karageorgiou, George Daskalakis
In this report, we propose a study protocol capable of improving IVF outcomes in subfertile women with expected normal ovarian response. This proposal derives from conflicting published data and observations in our daily practice, concerning the negative impact of progesterone (P4) elevation at the day of oocyte triggering on pregnancy outcomes. Our hypothesis points to the combination of two previous "suspects" of reduced success after assisted reproduction techniques (ART) - the endometrium ultrasonographic parameters and P4 elevation at the day of oocyte triggering on their impact on pregnancy outcomes...
May 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29757594/transport-ivf-icsi-results-of-a-25-year-experience
#6
Fernanda G E Raffo, Jorge Blaquier
OBJECTIVE: This report presents a summary of the outcomes achieved at ART center FERTILAB in Buenos Aires, Argentina, with transport IVF-ICSI for 25 years (1990-2014). METHODS: This report included all patients submitted to oocyte retrieval for IVF-ICSI whose oocytes were transported from sites of aspiration located 0.5-58 kilometers away from the central laboratory. The numeric data herein reported were taken from annual reports submitted by our institution (Fertilab) and, for purposes of comparison, by all Argentinian centers to the Latin American Registry of Assisted Reproduction (RLA) within the same time period...
May 14, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29744474/utilization-of-cryopreserved-sperm-cells-based-on-the-indication-for-storage
#7
Graham Luke Machen, Stephanie E Harris, Erin T Bird, Monica L Brown, Dale A Ingalsbe, Milaida M East, Michelle Reyes, Thomas J Kuehl
Purpose: Cryopreservation of sperm from human semen has been available since the 1950s. The actual utilization of available cryopreservation technology has been infrequently reported. We set out to examine the utilization and outcomes of cryopreserved sperm cells based on the indication for storage. Materials and Methods: A dataset was developed from retrospective review. The purposes for cryopreservation, eventual utilization, and outcomes of use for insemination were recorded...
May 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29713550/role-of-varicocele-treatment-in-assisted-reproductive-technologies
#8
REVIEW
Mehmet G Sönmez, Ahmet H Haliloğlu
Objective: In this review, we investigate the advantage of varicocele repair prior to assisted reproductive technologies (ART) for infertile couples and provide cost analysis information. Materials and methods: We searched the following electronic databases: PubMed, Medline, Excerpta Medica Database (Embase), Cumulative Index to Nursing and Allied Health Literature (CINAHL). The following search strategy was modified for the various databases and search engines: 'varicocele', 'varicocelectomy', 'varicocele repair', 'ART', ' in vitro fertilisation (IVF)', 'intracytoplasmic sperm injection (ICSI)'...
March 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29707937/detection-of-y-chromosome-microdeletions-and-hormonal-profile-analysis-of-infertile-men-undergoing-assisted-reproductive-technologies
#9
Ardeshir Bahmanimehr, Shahryar Zeighami, Bahia Namavar Jahromi, Zahra Anvar, Mohammad Ebrahim Parsanezhad, Maryam Davari, Somayeh Montazeri
Background: Y chromosome deletions (YCDs) in azoospermia factor (AZF) region are associated with abnormal spermatogenesis and may lead to azoospermia or severe oligozoospermia. Assisted reproductive technologies (ART) by intracytoplasmic sperm injection (ICSI) and testicular sperm extraction (TESE) are commonly required for infertility management of patients carrying YCDs. The aim of this study was to estimate the frequency of YCDs, to find the most frequent variant in infertile men candidate for ART and to compare YCD distribution with a control fertile group...
July 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29700730/surgically-acquired-sperm-use-for-assisted-reproductive-technology-trends-and-perinatal-outcomes-usa-2004-2015
#10
Jennifer F Kawwass, Jeani Chang, Sheree L Boulet, Ajay Nangia, Akanksha Mehta, Dmitry M Kissin
PURPOSE: To compare national trends and perinatal outcomes following the use of ejaculated versus surgically acquired sperm among IVF cycles with male factor infertility. METHODS: This retrospective cohort includes US fertility clinics reporting to the National ART Surveillance System between 2004 and 2015. Fresh, non-donor IVF male factor cycles (n = 369,426 cycles) were included. We report the following outcomes: (1) Trends in surgically acquired and ejaculated sperm...
April 26, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29697805/single-cell-analysis-of-ca2-i-signalling-in-sub-fertile-men-characteristics-and-relation-to-fertilization-outcome
#11
Mark C Kelly, Sean G Brown, Sarah M Costello, Mythili Ramalingam, Ellen Drew, Stephen J Publicover, Christopher L R Barratt, Sarah Martins Da Silva
STUDY QUESTION: What are the characteristics of progesterone-induced (CatSper-mediated) single cell [Ca2+]i signals in spermatozoa from sub-fertile men and how do they relate to fertilizing ability? SUMMARY ANSWER: Single cell analysis of progesterone-induced (CatSper-mediated) [Ca2+]i showed that reduced progesterone-sensitivity is a common feature of sperm from sub-fertile patients and is correlated with fertilization rate. WHAT IS KNOWN ALREADY: Stimulation with progesterone is a widely used method for assessing [Ca2+]i mobilization by activation of CatSper in human spermatozoa...
April 25, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29696351/the-effects-of-superovulation-with-gonadotropins-on-autoantibody-levels-in-patients-undergoing-assisted-reproductive-cycles
#12
Mahnaz Ashrafi, Elham Amirchaghmaghi, Arezoo Arabipoor, Samira Vesali, Reza Salman-Yazdi
PURPOSE: To evaluate the effect of controlled ovarian stimulation (COH) with gonadotropins on the serum levels of autoantibodies in the women who underwent in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) cycles and to compare basal levels of these autoantibodies between groups according to history of COH. METHODS: This prospective cohort study was performed from October 2014 to March 2016 in the Royan Institute. The volunteered infertile women with regard to the inclusion criteria, who underwent IVF/ICSI cycles, were recruited...
April 25, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29620419/artificial-oocyte-activation-with-calcium-ionophore-for-frozen-sperm-cycles
#13
Seda Karabulut, Özlem Aksünger, Can Ata, Yusuf Sağıroglu, İlknur Keskin
Fertilization problems are the major problems that may be faced in 30-55% of the patients during an intracytoplasmic sperm injection (ICSI) cycle. A successful oocyte activation depends on factors related to both sperm and oocyte, and one of the important factors that mediates the process is Ca2+ concentration within the oocyte. Artificial oocyte activation (AOA) is a method used for fertilization problems that commonly involve the usage of Ca2+ ionophores and is usually used in problems such as total fertilization failure (TFF) and globozoospermia...
April 5, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29600727/clinical-and-neonatal-outcomes-of-intrauterine-insemination-with-frozen-donor-sperm
#14
Linjun Chen, Lihua Zhu, Changming Cai, Guijun Yan, Haixiang Sun
This retrospective study evaluated the association between frozen donor sperm used for intrauterine insemination and clinical and neonatal outcomes, including 304 singleton pregnancies resulting from artificial insemination by the husband (AIH) and 173 singleton pregnancies resulting from artificial insemination by a donor (AID). The clinical outcomes for AID showed no increased risk of abortion, ectopic pregnancy or pregnancy complications compared to those for AIH. There were no differences in gender, gestational age or prematurity of live births between the two groups...
March 30, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29572694/total-urokinase-type-plasminogen-activator-upa-levels-in-seminal-plasma-are-associated-with-positive-assisted-reproductive-technology-outcomes
#15
Juan Carlos Martinez-Soto, José Landeras, Marta Mollá, Irene Mondejar, María Nicolás, Laura Fernández-Olmedilla, Martina Trabalón, Pilar Coy, Joaquín Gadea
PURPOSE: The plasminogen/plasmin system is an important extracellular protease system whose function has been implicated in male reproductive function. However, its clinical relevance to fertility in human assisted reproduction technologies has not been systematically investigated. Here, we examined whether total and active populations of urokinase-type plasminogen activator (uPA) in human seminal plasma and spermatozoa are predictive of pregnancy outcome in couples undergoing insemination or intracytoplasmic sperm injection (ICSI)...
March 23, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29546422/thyroid-autoimmunity-and-intracytoplasmic-sperm-injection-outcome-a-systematic-review-and-meta-analysis
#16
Kris Poppe, Candice Autin, Flora Veltri, Pierre Kleynen, Lidia Grabczan, Serge Rozenberg, Lieveke Ameye
Background: Since 2010, three meta-analyses have been published on the impact of thyroid autoimmunity (TAI) on pregnancy outcomes in infertile women treated with assisted reproductive technology (ART). The initially observed high risk of miscarriage became very low in the most recent meta-analysis published in 2016. Objective: To investigate whether the lower risk of miscarriage in the latest meta-analysis was associated with the increased use of intracytoplasmic sperm injection (ICSI) in recent studies...
March 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29538675/determinants-of-monozygotic-twinning-in-art-a-systematic-review-and-a-meta-analysis
#17
Kathrine Vauvert R Hviid, Sara Sofia Malchau, Anja Pinborg, Henriette Svarre Nielsen
BACKGROUND: The incidence of monozygotic twins (MZT) after ART appears to be higher than the incidence after spontaneous conceptions contradicting the aim of ART to avoid multiple pregnancies because of the associated risks. OBJECTIVE AND RATIONALE: The aim was to study the frequency of MZT after IVF and ICSI and how it is influenced by the day of embryo transfer, maternal age, zona pellucida manipulation, controlled ovarian stimulation, stimulation protocol, culture media and embryo quality...
March 12, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29520735/neonatal-outcomes-among-twins-stratified-by-method-of-conception-secondary-analysis-of-maternal-fetal-medicine-mfmu-network-database
#18
Jaimin S Shah, Susan Hosseini Nasab, Neil Chappell, Han-Yang Chen, Amy Schutt, Hector Mendez-Figueroa
PURPOSE: To investigate whether twin pregnancies conceived by different forms of fertility treatments are associated with adverse neonatal outcomes and to examine the difference in maternal and obstetrical characteristics between patients. METHODS: Our study was a retrospective analysis of twin pregnancies conceived by fertility treatments from a prospectively collected database. Treatments were stratified into two groups: group 1 (ART) consisted of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), and group 2 (non-ART) included intrauterine insemination (IUI) and ovulation induction (OI)...
March 9, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29499098/the-impact-of-histones-linked-to-sperm-chromatin-on-embryo-development-and-art-outcome
#19
C Fournier, E Labrune, J Lornage, G Soignon, S Giscard d'Estaing, J-F Guérin, M Benchaib
The purpose of this study was to investigate the relationship between the proportion of sperm chromatin linked to remaining histone and assisted reproductive technology (ART) outcome. A prospective cohort study was performed on couples undergoing ART process at the Department of Reproduction Medicine (HFME, Bron, France). The histone-to-protamine ratio (HPR) was measured using the method described by Wykes & Krawetz (2003) J Biol Chem 278, 29471. The correlations with sperm DFI, blastocyst formation, pregnancy rate, and delivery rate were investigated...
March 2, 2018: Andrology
https://www.readbyqxmd.com/read/29497821/birth-prevalence-of-congenital-malformations-in-singleton-pregnancies-resulting-from-in-vitro-fertilization-intracytoplasmic-sperm-injection-worldwide-a-systematic-review-and-meta-analysis
#20
REVIEW
Letao Chen, Tubao Yang, Zan Zheng, Hong Yu, Hua Wang, Jiabi Qin
PURPOSE: We conducted a systematic review and meta-analysis to estimate the worldwide birth prevalence of total congenital malformations (CMs), major CMs, and specific CMs according to organs and systems classification associated with IVF/ICSI singleton pregnancies. METHODS: Unrestricted searches were conducted, with an end-date parameter of 1 June 2017, of PubMed, Embase, Google Scholar, Cochrane Libraries, and Chinese databases, to identify cohort studies assessing CMs associated with IVF/ICSI singleton pregnancies...
May 2018: Archives of Gynecology and Obstetrics
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