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https://www.readbyqxmd.com/read/29352176/renal-scattered-tubular-like-cells-confer-protective-effects-in-the-stenotic-murine-kidney-mediated-by-release-of-extracellular-vesicles
#1
Xiangyu Zou, Soon Hyo Kwon, Kai Jiang, Christopher M Ferguson, Amrutesh S Puranik, Xiangyang Zhu, Lilach O Lerman
To test the hypothesis that intrinsic renal scattered tubular cells (STC-like cells) contribute to repairing injured tubular epithelial cells (TEC) by releasing extracellular vesicle (EV). EV released from primary cultured pig STC-like cells were confirmed by electron microscopy. Antimycin-A (AMA)-induced injured proximal TEC (PK1 cells) were co-cultured with STC-like cells, STC-like cells-derived EV, or EV-free conditioned-medium for 3 days. Cellular injury, oxidative stress and mitochondrial function were assessed...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29348533/structured-thermal-surface-for-radiative-camouflage
#2
Ying Li, Xue Bai, Tianzhi Yang, Hailu Luo, Cheng-Wei Qiu
Thermal camouflage has been successful in the conductive regime, where thermal metamaterials embedded in a conductive system can manipulate heat conduction inside the bulk. Most reported approaches are background-dependent and not applicable to radiative heat emitted from the surface of the system. A coating with engineered emissivity is one option for radiative camouflage, but only when the background has uniform temperature. Here, we propose a strategy for radiative camouflage of external objects on a given background using a structured thermal surface...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29346894/size-scaling-of-failure-strength-with-fat-tailed-disorder-in-a-fiber-bundle-model
#3
Viktória Kádár, Zsuzsa Danku, Ferenc Kun
We investigate the size scaling of the macroscopic fracture strength of heterogeneous materials when microscopic disorder is controlled by fat-tailed distributions. We consider a fiber bundle model where the strength of single fibers is described by a power law distribution over a finite range. Tuning the amount of disorder by varying the power law exponent and the upper cutoff of fibers' strength, in the limit of equal load sharing an astonishing size effect is revealed: For small system sizes the bundle strength increases with the number of fibers, and the usual decreasing size effect of heterogeneous materials is restored only beyond a characteristic size...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346020/sequential-ridge-augmentation-sra-protocol-for-hard-and-soft-tissue-grafting-in-alveolar-ridge-deficiencies-a-proposed-algorithm
#4
Neel Bhatavadekar, Amit Srikant Gharpure
The success of implant-based treatment is dependent on the correct restorative position of dental implants in the oral cavity. Often, the final prostheses require dental implants to be placed at sites with inadequate native hard and soft tissue. Bone augmentation procedures and materials have been extensively studied in the literature and various techniques have been developed over time to obtain adequate hard tissue at proposed implant sites. In the recent past, few publications have also studied soft tissue development at planned implant sites...
January 18, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29341474/effect-of-staining-beverages-on-color-and-translucency-of-cad-cam-composites
#5
S H Q Quek, A U J Yap, V Rosa, K B C Tan, K H Teoh
This study investigated the color (ΔE) and translucency changes (ΔTP) of CAD/CAM composites after exposure to staining solutions using both spectrophotometer and shade-matching device. Direct (Filtek Z350XT [ZT]), indirect (Shofu Ceramage [CE]) and CAD/CAM (Shofu HC Block [HC], Lava Ultimate [LU], Vita Enamic [EN]) composite specimens measuring 12 × 14 × 1.5 mm were fabricated, divided into five groups (n = 8), and immersed in cola, tea, coffee, red wine, distilled water (control) at 37°C for 7 days...
January 17, 2018: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29337644/performance-of-monolithic-and-veneered-zirconia-crowns-after-endodontic-treatment-and-different-repair-strategies
#6
A Scioscia, A Helfers, S Soliman, G Krastl, N U Zitzmann
OBJECTIVES: To investigate failure loads of monolithic and veneered all-ceramic crowns after root canal treatment and to analyze marginal integrity of repair fillings. METHODS AND MATERIALS: Seventy-two human molars were restored with monolithic (Zr-All) or veneered (Zr-Ven) zirconia crowns. Molars were assigned to six groups (n=12 per group) depending on restoration material, access type (no access cavity [control] or endodontic treatment [test]), and type of filling (one-step [1-st] or two-step [2-st])...
January 16, 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29336497/effects-of-treatment-with-maraviroc-a-ccr5-inhibitor-on-a-human-hepatic-stellate-cell-line
#7
N Coppola, A Perna, A Lucariello, S Martini, M Macera, M A Carleo, G Guerra, V Esposito, A De Luca
After an acute liver damage, tissue regeneration repairs lesions with degradation of deposed fibrotic material, while mechanisms of tissue restoration are persistently activated following several repeated injuries, inducing deposition of extracellular matrix. (ECM). Factors responsible for ECM remodeling have been identified in a pathway involving a family of zinc-dependent enzyme matrix metalloproteinases (MMPs), together with tissue inhibitor of metalloproteinases (TIMPs). Recent experimental models suggested a role of CCR5 receptor in the genesis of liver fibrosis...
January 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29336173/genome-analysis-and-clinical-implications-of-the-bacterial-communities-in-early-biofilm-formation-on-dental-implants-restored-with-titanium-or-zirconia-abutments
#8
Flávia Correa Raffaini, Alice Ramos Freitas, Thalisson Saymo Oliveira Silva, Tarsis Cavagioni, Jessica Felix Oliveira, Rubens Ferreira Albuquerque Junior, Vinícius Pedrazzi, Ricardo Faria Ribeiro, Cássio do Nascimento
This cross-sectional study aimed to identify and quantify up to 42 target species colonizing the early biofilm of dental implants restored with titanium or zirconia abutments. A total of 720 samples from 20 healthy individuals were investigated. Biofilm samples were collected from the peri-implant sulci, inner parts of implants, abutment surfaces and prosthetic crowns over a functioning period of 30 days. Checkerboard DNA-DNA hybridization was used for microbial detection and quantitation. Clinical characteristics (probing depth, bleeding on probing, clinical attachment level and marginal bone loss) were also investigated during the monitoring period...
January 16, 2018: Biofouling
https://www.readbyqxmd.com/read/29333332/next-generation-tissue-engineering-of-orthopedic-soft-tissue-to-bone-interfaces
#9
Alexander J Boys, Mary Clare McCorry, Scott Rodeo, Lawrence J Bonassar, Lara A Estroff
Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues...
September 2017: MRS Communications
https://www.readbyqxmd.com/read/29332499/examination-of-an-in-vitro-methodology-to-evaluate-the-biomechanical-performance-of-nucleus-augmentation-in-axial-compression
#10
Sebastien Nf Sikora, Danielle E Miles, Sami Tarsuslugil, Marlène Mengoni, Ruth K Wilcox
Intervertebral disc degeneration is one of the leading causes of back pain, but treatment options remain limited. Recently, there have been advances in the development of biomaterials for nucleus augmentation; however, the testing of such materials preclinically has proved challenging. The aim of this study was to develop methods for fabricating and testing bone-disc-bone specimens in vitro for examining the performance of nucleus augmentation procedures. Control, nucleotomy and treated intervertebral disc specimens were fabricated and tested under static load...
January 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29331224/centrifugal-partition-chromatography-enables-selective-enrichment-of-trimeric-and-tetrameric-proanthocyanidins-for-biomaterial-development
#11
Rasika S Phansalkar, Joo-Won Nam, Shao-Nong Chen, James B McAlpine, Ariene A Leme, Berdan Aydin, Ana-Karina Bedran-Russo, Guido F Pauli
Proanthocyanidins (PACs) find wide applications for human use including food, cosmetics, dietary supplements, and pharmaceuticals. The chemical complexity associated with PACs has triggered the development of various chromatographic techniques, with countercurrent separation (CCS) gaining in popularity. This study applied the recently developed DESIGNER (Depletion and Enrichment of Select Ingredients Generating Normalized Extract Resources) approach for the selective enrichment of trimeric and tetrameric PACs using centrifugal partition chromatography (CPC)...
December 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29327735/acquired-sensorineural-hearing-loss-in-children-current-research-and-therapeutic-perspectives
#12
M Ralli, R Rolesi, R Anzivino, R Turchetta, A R Fetoni
The knowledge of mechanisms responsible for acquired sensorineural hearing loss in children, such as viral and bacterial infections, noise exposure, aminoglycoside and cisplatin ototoxicity, is increasing and progressively changing the clinical management of affected patients. Viral infections are by far the most relevant cause of acquired hearing loss, followed by aminoglycoside and platinum derivative ototoxicity; moreover, cochlear damage induced by noise overexposure, mainly in adolescents, is an emerging topic...
December 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29326512/evaluating-the-effect-of-different-conditioning-agents-on-the-shear-bond-strength-of-resin-modified-glass-ionomers
#13
Namith Rai, Rajaram Naik, Ravi Gupta, Shobana Shetty, Amith Singh
Aim of the Study: This study aims to evaluate the effects three different conditioning agents on the shear bond strength of resin-modified glass ionomers to human dentin. Materials and Methods: One hundred and twenty recently extracted, caries-free premolars and molars will be cleaned of debris and disinfected in a 0.5% solution of sodium hypochlorite and sterile water for 30 min. The occlusal surface of each tooth will be reduced using conventional model trimmer with water to produce the dentin surface...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326506/the-bond-strength-of-nanohybrid-and-nanoceramic-composites-to-feldspathic-porcelain
#14
Hatice Özdemir, Nuran Dinçkal Yanikoglu
Background: Porcelain fracture is the most important problem in fixed prosthetic restorations. The replacement of fractured restoraions isn't often prefer by patients and dentists. Intraoral repair of fractured porcelain is a big alternative for patient and dentist. For this reason, dentists try to improve different surface treatments to increase the bond strength between porcelain and repair materials such as composite resins. Aims: The aim of this study was to evaluate the shear bond strength (SBS) of nano-hybrid (Nh...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326416/strategies-to-restore-adenosine-triphosphate-atp-level-after-more-than-20-hours-of-cold-ischemia-time-in-human-marginal-kidney-grafts
#15
Matteo Ravaioli, Maurizio Baldassare, Francesco Vasuri, Gianandrea Pasquinelli, Maristella Laggetta, Sabrina Valente, Vanessa De Pace, Flavia Neri, Antonio Siniscalchi, Chiara Zanfi, Valentina R Bertuzzo, Paolo Caraceni, Davide Trerè, Pasquale Longobardi, Antonio D Pinna
BACKGROUND The persisting organ shortage in the field of transplantation recommends the use of marginal kidneys which poorly tolerate ischemic damage. Adenosine triphosphate (ATP) depletion during cold ischemia time (CIT) is considered crucial for graft function. We tested different strategies of kidney perfusion before transplantation in the attempt to improve the technique. MATERIAL AND METHODS Twenty human discarded kidneys from donors after brain death and with at least 20 hours of CIT were randomized to the following experimental groups (treatment time three-hours at 4°C): a) static cold storage (CS); b) static cold hyperbaric oxygenation (Hyp); c) hypothermic perfusion (PE); d) hypothermic perfusion in hyperbaric oxygenation (PE-Hyp); and e) hypothermic oxygenated perfusion (PE-O2)...
January 12, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29326062/functional-effects-of-an-interpenetrating-polymer-network-on-articular-cartilage-mechanical-properties
#16
Janne Ta Mäkelä, Benjamin G Cooper, Rami K Korhonen, Mark W Grinstaff, Brian D Snyder
OBJECTIVE: Depletion of glycosaminoglycans (GAGs) and degradation of collagen network are early hallmarks of osteoarthritis. Currently, there are no chondroprotective therapies that mitigate the loss of GAGs or effectively restore the collagen network. Recently, a novel polymeric cartilage supplement was described that forms a charged interpenetrating polymer network (IPN) reconstituting the hydrophilic properties of the extracellular matrix. To investigate the mechanism by which this hydrophilic IPN improves articular cartilage material properties, a finite element (FE) model is used to evaluate the IPN's effect on the fibrillar collagen network, nonfibrillar matrix, and interstitial fluid flow...
January 8, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29324684/comparative-effect-of-self-or-dual-curing-on-polymerization-kinetics-and-mechanical-properties-in-a-novel-dental-resin-based-composite-with-alkaline-filler-running-title-resin-composites-with-alkaline-fillers
#17
Nicoleta Ilie
Dental bulk-fill restorations with resin-composites (RBC) are increasing in popularity, but doubts concerning insufficient curing in depth still disconcert clinicians. An alternative might be offered by modern dual-cured RBCs, which additionally provide bioactive properties. This study assessed the impact of additional light-curing on polymerization kinetics, the degree of conversion (DC) and mechanical properties of a novel, dual-cured RBC with alkaline fillers. Since the bioactivity of a material often implies a release of compounds, the mechanical stability in simulated clinical environments was also evaluated...
January 11, 2018: Materials
https://www.readbyqxmd.com/read/29323782/the-effect-of-surface-treatments-on-the-mechanical-and-optical-behaviors-of-cad-cam-restorative-materials
#18
Sevcan Kurtulmus-Yilmaz, Esra Cengiz, Salim Ongun, Izgen Karakaya
PURPOSE: To evaluate the effect of different surface treatments on mechanical and optical properties of lithium disilicate ceramic (IPS e.max CAD), 2 resin nanoceramics (Lava Ultimate, GC Cerasmart), and polymer-infiltrated ceramic network material (Vita Enamic). MATERIALS AND METHODS: CAD/CAM blocks were sectioned into 4 × 1 × 14 mm3 bars for three-point bending test and 1 × 8 × 8 mm3 square specimens were obtained for color and translucency measurements. Bar-shaped and square specimens were divided into five groups according to the surface treatment method as: control (no treatment), hydrofluoric acid etching, airborne-particle abrasion, 2 W and 3 W Er,Cr:YSGG laser irradiation (n = 10)...
January 11, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29323776/remineralization-of-natural-human-carious-dentin-lesions-with-an-experimental-whisker-reinforced-atraumatic-restorative-treatment-composite
#19
Chao Zhang, Stephen D Campbell, Sabine H Dickens, Bin Yang
PURPOSE: To evaluate the remineralization of natural human dentin caries with an experimental whisker-reinforced Atraumatic Restorative Treatment (ART) composite. MATERIALS AND METHODS: Teeth with moderate active dentin caries were prepared with caries-disclosing dye and hand instruments, restored with ART or resin-modified glass ionomer cement (RM-GIC), and then wet sliced into 120-μm sections with 15 sections in each group. After taking transverse microradiographs and implementing digital image analysis to determine the "mineral-loss-before," each section was incubated in artificial saliva solution (pH = 7...
January 11, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29322626/restorations-in-primary-teeth-a-systematic-review-on-survival-and-reasons-for-failures
#20
REVIEW
Luiz Alexandre Chisini, Kauê Collares, Mariana Gonzalez Cademartori, Luísa Jardim Corrêa de Oliveira, Marcus Cristian Muniz Conde, Flávio Fernando Demarco, Marcos Britto Corrêa
BACKGROUND: Several restorative materials with specific indications are used for filling cavities in primary teeth. AIM: To systematically review the literature in order to investigate the longevity of primary teeth restorations and the reasons for failure. DESIGN: Electronic databases were screened, and eligible studies were hand-searched to find longitudinal clinical studies evaluating the survival of restorations (class I, class II, and crown) placed with different materials in primary teeth with at least one year of follow-up...
January 10, 2018: International Journal of Paediatric Dentistry
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