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cutaneous polyarteritis nodosa

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https://www.readbyqxmd.com/read/27862152/cutaneous-polyarteritis-nodosa-localized-to-a-region-of-lymphedema-secondary-to-streptococcus-viridans-cellulitis-and-multiple-surgeries
#1
Andrew Matsumoto, Rami N Al-Rohil, Marina Bravin, Lori Anderson, Danielle Wroblewski, J Andrew Carlson
Cutaneous polyarteritis nodosa (CPAN) is a chronic, indolent, single organ arteritis that generally presents with lower extremity nodules and/or livedo racemosa, accompanied by malaise and arthralgias. CPAN is often triggered by infection, commonly Group A streptococcal species, and is considered an autoimmune reaction. Scarring from surgery and obliterative lymphangiitis from bacterial cellulitis are causes of lymphedema. Lymphedematous skin is predisposed to autoimmune disorders. Herein we report a 53yo woman who developed CPAN restricted to a localized area of the right upper arm-shoulder that had undergone multiple surgeries, complicated by episodes of Streptococcus viridans cellulitis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27787337/approach-to-cutaneous-vasculitides-with-special-emphasis-on-small-vessel-vasculitis-histopathology-and-direct-immunofluorescence
#2
Cuyan Demirkesen
PURPOSE OF REVIEW: The present review will focus on recent publications in cutaneous vasculitides. RECENT FINDINGS: Some histopathological and clinical features, such as papillary dermal edema, perivascular C3 deposition, clinically evident edema, and lesions above the waist, may point out renal or gastrointestinal involvement in Henoch-Schönlein purpura (HSP). HSP associated with familial Mediterranean fever differs from typical isolated HSP by showing no deposits of IgA, much younger age, and location of the lesions on the face or the trunk...
January 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27785929/a-hereditary-clue-for-the-development-of-cutaneous-polyarteritis-nodosa-in-siblings
#3
Shinji Akioka
No abstract text is available yet for this article.
October 27, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27592619/reappraisal-of-histopathology-of-cutaneous-polyarteritis-nodosa
#4
Ari Morimoto, Ko-Ron Chen
BACKGROUND: There is controversy on whether lymphocytic thrombophilic arteritis (LTA) and macular arteritis (MA) are a different entity from cutaneous polyarteritis nodosa (C-PAN). OBJECTIVE: To evaluate the controversy on LTA/MA by examining the morphologic changes during the dynamic inflammatory process. MATERIALS AND METHODS: A clinical and histopathological investigation of 46 biopsy specimens from 21 histopathologically proven C-PAN patients at our hospital was performed...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27564269/the-clinical-spectrum-of-medium-sized-vessel-vasculitis
#5
Fatma Alibaz-Oner, Matthew J Koster, Cynthia S Crowson, Ashima Makol, Steven R Ytterberg, Carlo Salvarani, Eric L Matteson, Kenneth J Warrington
OBJECTIVES: Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis of medium-sized visceral vessels. However, cutaneous arteritis (CA) and gastrointestinal (GI) vasculitis are forms of single organ vasculitis having indistinguishable histopathological findings from PAN. The aim of this study was to evaluate and compare the clinical characteristics, treatment, and outcomes of patients with systemic PAN, CA and GI vasculitis. METHODS: Retrospective cohorts were assembled of patients with PAN, CA and GI vasculitis between 1980 and 2014...
August 26, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27463862/error-in-complementary-dna-nomenclature-in-dermatologic-features-of-ada2-deficiency-in-cutaneous-polyarteritis-nodosa
#6
Roshini S Abraham, Lawrence E Gibson
No abstract text is available yet for this article.
September 1, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27345569/presence-of-anti-phosphatidylserine-prothrombin-complex-antibodies-and-anti-moesin-antibodies-in-patients-with-polyarteritis-nodosa
#7
Tatsuro Okano, Sora Takeuchi, Yoshinao Soma, Koya Suzuki, Sachiko Tsukita, Akihiro Ishizu, Kazuo Suzuki, Tamihiro Kawakami
We measured both serum anti-phosphatidylserine-prothrombin complex (anti-PSPT) antibodies and anti-moesin antibodies, as well as various cytokines (interleukin [IL]-2, IL-4, IL-5, IL-10, IL-13, IL-17, granulocyte macrophage colony-stimulating factor, γ-interferon, tumor necrosis factor-α) levels in polyarteritis nodosa (PAN) patients with cutaneous manifestations. All patients showed the presence of a histological necrotizing vasculitis in the skin specimen. They were treated with i.v. cyclophosphamide pulse therapy (IV-CY) and prednisolone therapy or steroid pulse therapy...
June 27, 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27299947/a-case-report-of-cutaneous-polyarteritis-nodosa-in-siblings
#8
Toshitaka Kizawa, Yuko Yoto, Miyako Mizukami, Takeshi Tsugawa, Takako Takeuchi, Hotaka Kamasaki, Yasue Ishii-Osai, Toshiharu Yamashita, Kazushige Nagai, Tsukasa Hori, Hiroyuki Tsutsumi
Cutaneous polyarteritis nodosa (CPAN) is characterized by a necrotizing vasculitis of small and medium-sized arteries in the skin, which can be associated with fever, arthralgia, myalgia, and neuropathy, but, unlike polyarteritis nodosa (PAN), there is no visceral involvement. CPAN is rare in childhood. We report two siblings who developed CPAN during childhood. Interestingly, both had Mediterranean fever gene (MEFV) mutation, i.e. heterozygous E148Q. They also shared HLA-A24, -DR15 alleles. Simultaneous occurrence of MEFV mutation and HLA alleles with CPAN has never been reported in Japan...
June 14, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27123310/polyarteritis-nodosa-diagnostic-challenges-in-a-patient-with-cutaneous-vasculitis-psoriasis-psoriatic-arthritis-and-pancytopenia-fatal-progression-after-treatment-with-g-csf
#9
Paresh Jobanputra
A 60-year-old man presented with cutaneous vasculitis, leucopenia and psoriasis. He was treated initially with ciclosporin A. On withdrawal of ciclosporin, due to inadequate improvement of cutaneous vasculitis, he developed psoriatic arthritis. Worsening neutropenia and pancytopenia, believed to be immune mediated, developed. He was treated with prednisolone, methotrexate and adalimumab but developed pneumocystis pneumonia. Leucocyte levels improved markedly with granulocyte colony-stimulating factor (G-CSF)...
April 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/27060697/deposition-of-elafin-in-the-involved-vascular-wall-of-neutrophil-mediated-cutaneous-vasculitis
#10
J Muto, N Fujimoto, K Ono, T Kobayashi, K R Chen, S Suzuki, H Wachi, S Tajima
BACKGROUND: Neutrophil elastase plays an important role in skin inflammation induced by neutrophil infiltration. Elafin is an inducible elastase inhibitor expressed by keratinocytes, and is known to be involved in pathogenesis of neutrophilic skin disorders such as psoriasis. METHODS: Immunohistochemical studies of elafin expression in the cases of vasculitis were performed. Induction of elafin expression in cultured vascular cells and its effect on neutrophil migration were studied in vitro...
September 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27059682/deficiency-of-adenosine-deaminase-type-2-a-description-of-phenotype-and-genotype-in-fifteen-cases
#11
Sira Nanthapisal, Claire Murphy, Ebun Omoyinmi, Ying Hong, Ariane Standing, Stefan Berg, Maria Ekelund, Stephen Jolles, Lorraine Harper, Taryn Youngstein, Kimberly Gilmour, Nigel J Klein, Despina Eleftheriou, Paul A Brogan
OBJECTIVE: To describe the clinical features, genotype, and treatment in a series of subjects with confirmed adenosine deaminase 2 (ADA2) deficiency. METHODS: All symptomatic subjects were referred for genetic testing for suspected ADA2 deficiency; relatives of index cases were also screened. Demographic, clinical, and laboratory characteristics and treatments were recorded. Genetic analyses included whole-exome sequencing in 4 subjects and Sanger sequencing of CECR1 (the gene for cat eye syndrome chromosome region candidate 1) in all subjects...
September 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27036226/-hemorrhagic-shock-revealing-multiple-digestive-microaneurysms-in-a-patient-with-systemic-lupus-erythematosus-case-report-and-literature-review
#12
C Anquetil, C Stavris, N Chanson, M Lambert, E Hachulla, D Launay, P Y Hatron
INTRODUCTION: The vascular disorders in systemic lupus erythematosus (SLE) result from various mechanisms and presentations (inflammatory disease or vasculitis, atherosclerosis). CASE REPORT: We report on a 34-year-old man with cutaneous, articular, neurological and nephrologic SLE. He presented with catastrophic haemorrhage on microaneurysm rupture of the left hepatic artery. After blood transfusions and immunosuppressive treatments, his condition improves. CONCLUSION: Uncommon complication in SLE patients, digestive vasculitis with microaneurysms may occur as in polyarteritis nodosa...
March 29, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27009824/leopard-skin-appearance-of-cutaneous-polyarteritis-nodosa-on-18ffluorodeoxyglucose-positron-emission-tomography
#13
Masaki Shimizu, Natsumi Inoue, Mao Mizuta, Yasuhiro Ikawa, Akihiro Yachie
No abstract text is available yet for this article.
June 2016: Rheumatology
https://www.readbyqxmd.com/read/27009025/incidence-and-clinical-features-of-paediatric-vasculitis-in-eastern-china-14-year-retrospective-study-1999-2013
#14
Youying Mao, Lei Yin, Hui Xia, Hua Huang, Zhengyu Zhou, Tongxin Chen, Wei Zhou
OBJECTIVES: To determine the incidence and clinical features of paediatric primary vasculitis in patients from one centre in Eastern China. METHODS: Medical records of paediatric patients diagnosed with primary vasculitis between January 1999 and December 2013 were retrospectively reviewed. For Henoch-Schönlein purpura (HSP) and Kawasaki disease (KD), patients included in the analyses had data available for the previous 5 years. RESULTS: In total, 1896 patients were identified, of whom 1100 had HSP, 760 had KD, 23 had Takayasu arteritis, five had polyarteritis nodosa, four had cutaneous polyarteritis, three had Behçet's disease and one had microscopic polyangiitis...
June 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27002952/leukocytoclastic-vasculitis-associated-with-hairy-cell-leukemia-at-diagnosis-a-case-report-and-review-of-the-literature
#15
Alessandro Broccoli, Letizia Gandolfi, Cinzia Pellegrini, Claudio Agostinelli, Lisa Argnani, Pier Luigi Zinzani
BACKGROUND: Autoimmune manifestations may occur in patients with hairy cell leukemia (HCL), and some rare cases of polyarteritis nodosa and leukocytoclastic vasculitis have been reported. However, data regarding the treatment of these cutaneous manifestations are lacking, given the rarity of the concomitance of HCL and vasculitic syndromes. CASE PRESENTATION: We present a 37-year-old man with paraneoplastic leukocytoclastic vasculitis complicating newly diagnosed HCL...
March 16, 2016: Tumori
https://www.readbyqxmd.com/read/26884100/polyarteritis-nodosa-a-contemporary-overview
#16
REVIEW
Armando De Virgilio, Antonio Greco, Giuseppe Magliulo, Andrea Gallo, Giovanni Ruoppolo, Michela Conte, Salvatore Martellucci, Marco de Vincentiis
Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis predominantly targeting medium-sized arteries. PAN is a rare form of vasculitis, and the precise frequency of this disease is difficult to determine. The major environmental factor associated with PAN is HBV infection. The pathogenesis of "idiopathic PAN" remains enigmatic, although the clinical responses to immunosuppressive therapy support the concept that immunological mechanisms play an active pathogenic role. The spectrum of disease ranges from involving a single organ to polyvisceral failure...
June 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26882797/-vasculitides-in-childhood-a-retrospective-study-in-a-period-from-2002-to-2012-at-the-department-of-paediatrics-university-hospital-centre-zagreb
#17
Marija Jelusić, Lucija Kostić, Marijan Frković, Masa Davidović, Ivan Malcić
The aim of our study was to analyze clinical features, laboratory findings, treatment, course and outcome of different types of vasculitis in children. All children aged up to 18 years that have been diagnosed with a vasculitis disorder from 2002. to 2012. at the Department of Paediatric, University Hospital Centre Zagreb according to EULAR/PRES/PRINTO criteria were included in the study. Vasculitis was diagnosed in 180 children, 101 girls and 79 boys, mean age 7.19 ± 3.7 years, with an average follow-up of 5...
2015: Reumatizam
https://www.readbyqxmd.com/read/26876385/epidemiological-clinical-and-laboratory-profiles-of-cutaneous-polyarteritis-nodosa-patients-report-of-22-cases-and-literature-review
#18
REVIEW
Paulo Ricardo Criado, Gabriela Franco Marques, Thamara Cristiane Alves Batista Morita, Jozélio Freire de Carvalho
UNLABELLED: Cutaneous polyarteritis nodosa (CPAN) is a rare disease that affects small and middle caliber vessels of the deep dermis and subcutaneous tissue and its etiopathology remains yet to be understood. METHODS: Retrospective review of twenty two cases diagnosed as CPAN and confirmed by skin biopsy over the last 11 years was evaluated in our department. RESULTS: We found predominance in white woman, mean age of 39.4 years, showing no comorbidities in most of our sample...
June 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26625555/cutaneous-polyarteritis-nodosa-associated-with-destructive-arthritis
#19
Lihi Atzmony, Hana Feuerman, Yair Molad, Yelena Didkovsky, Emmilia Hodak
No abstract text is available yet for this article.
September 2015: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/26526030/intravenous-immunoglobulins-for-cutaneous-polyarteritis-nodosa-resistant-to-conventional-treatment
#20
LETTER
L Breda, S Franchini, V Marzetti, F Chiarelli
No abstract text is available yet for this article.
2016: Scandinavian Journal of Rheumatology
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