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https://www.readbyqxmd.com/read/28430739/downstream-indication-to-revascularization-following-hybrid-cardiac-pet-mri-preliminary-results
#1
Julien Priamo, Dionysos Adamopoulos, Oliver Rager, Angela Frei, Stephane Noble, David Carballo, Osman Ratib, René Nkoulou
BACKGROUND: Hybrid PET/MRI allows the acquisition of both fluorine-18-fluorodeoxyglucose (F-FDG) PET and cardiac magnetic resonance (CMR) during one session. Whether this will result in different referral to coronary revascularization (CR) is unknown. We compared this new hybrid method with all-nuclear/all-CMR methods in the assessment of viable myocardium and in downstream referral to CR. PATIENTS AND METHODS: Overall, 12 patients with rest perfusion defects on a single photon emission computed tomography (SPECT) were recruited for cardiac viability assessment using a PET/MRI device...
April 20, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28427982/preoperative-evaluation-of-sellar-and-parasellar-macro-lesions-by-fluorine-18-fluorodeoxyglucose-positron-emission-tomography
#2
Masahiko Tosaka, Tetsuya Higuchi, Keishi Horiguchi, Tadashi Osawa, Yukiko Arisaka, Haruyasu Fujita, Yoshito Tsushima, Yuhei Yoshimoto
OBJECTIVE: Various pathologies can occur in the sellar and suprasellar regions. The potential of fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) for the preoperative evaluation of sellar and parasellar lesions was investigated. METHODS: A total of 49 patients aged 8 to 82 years with sellar and parasellar macroscopic lesions (≥10 mm) underwent FDG PET. Twenty-two patients had pituitary adenomas, including 14 non-functioning and 8 growth hormone (GH)-secreting adenomas...
April 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28427681/sonochemical-assisted-synthesis-of-rgo-zno-nanowire-arrays-for-photoelectrochemical-water-splitting
#3
Ibrahim Khan, Akram A M Ibrahim, Manzar Sohail, Ahsanulhaq Qurashi
This article presented the synthesis of a hybrid nanoarchitecture material composed of reduced graphene oxide (RGO) multiple sheets and ZnO nanowire arrays (NWAs) formed on an arbitrary ZnO coated fluorine doped tin oxide (FTO) substrates via pulse sonication and hydrothermal approach. The NWAs have high aspect-ratio, high density, apt positioning and well-ordered formation. FESEM images demonstrated that RGO layers have been effectively intercalated between and on the accessible surfaces of the ZnO NWAs. The diameter of ZnO nanowires is 80-150nm and length about 1-2μm...
July 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28426195/one-step-fabrication-of-non-fluorinated-transparent-super-repellent-surfaces-with-tunable-wettability-functioning-both-in-air-and-oil
#4
Mengying Long, Shan Peng, Xiaojun Yang, Wanshun Deng, Ni Wen, Kai Miao, Gongyun Chen, Xinrui Miao, Wenli Deng
In this paper, we have developed a one-step thermal treatment of polydimethylsiloxane (PDMS) liquid to create transparent super-repellent surface (TSS) and super-repellent powder. They are super-repellent toward water and ethylene glycol. During the one-step thermal treatment, PDMS soot generated and deposited onto glass slide (GS) surface to fabricate the TSS without fluorosilane modification. The facilely obtained TSS presented superhydrophobicity and self-cleaning property when immersed into very low-surface-tension oils such as petroleum ether, hexadecane, peanut oil, and dodecane...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28426071/ca-and-sr-tetrafluoroisophthalates-mechanochemical-synthesis-characterization-and-ab-initio-structure-determination
#5
Abdal-Azim Al-Terkawi, Gudrun Scholz, Ana Guilherme Buzanich, Stefan Reinsch, Franziska Emmerling, Erhard Kemnitz
New fluorinated coordination polymers were prepared mechanochemically by milling the alkaline earth metal hydroxides M(II)(OH)2·xH2O (M(II): Ca, Sr) with tetrafluoroisophthalic acid (H2mBDC-F4). The structures of [{Ca(mBDC-F4)(H2O)2}·H2O] (1) and [{Sr(mBDC-F4)(H2O)2}·H2O] (2) were determined based on ab initio calculations and their powder X-ray diffraction (PXRD) data. The compounds are isomorphous and crystallize in the orthorhombic space group P212121. The determined structures were validated by using extended X-ray absorption (EXAFS) data...
April 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28422888/18f-fdg-pet-ct-for-detection-of-the-primary-tumor-in-adults-with-extracervical-metastases-from-cancer-of-unknown-primary-a-systematic-review-and-meta-analysis
#6
Synne Alexandra Burglin, Søren Hess, Poul Flemming Høilund-Carlsen, Oke Gerke
BACKGROUND: Cancer of unknown primary (CUP) is a heterogeneous group of cancers, so called when a biopsy from a patient reveals malignancy without giving a clue to where in the body the primary tumor is located. Whole-body 18-fluorine-fluorodeoxyglucose positron-emission-tomography/computed tomography (18F-FDG PET/CT) is widely used for diagnosis and staging of most cancers. We hypothesized that 18F-FDG PET/CT-especially if used early-is suitable for the detection of the primary tumor in patients with CUP...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28422499/development-of-a-18f-labeled-radiotracer-with-improved-brain-kinetics-for-positron-emission-tomography-imaging-of-translocator-protein-18-kda-in-ischemic-brain-and-glioma
#7
Masayuki Fujinaga, Rui Luo, Katsushi Kumata, Yiding Zhang, Akiko Hatori, Tomoteru Yamasaki, Lin Xie, Wakana Mori, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Feng Wang, Ming-Rong Zhang
We designed four novel acetamidobenzoxazolone compounds 7a-d as candidates of positron emission tomography (PET) radiotracers for imaging translocator protein (18 kDa, TSPO) in ischemic brain and glioma. Among these compounds, 2-(5-(6-fluoropyridin-3-yl)-2-oxobenzo[d]oxazol-3(2H)-yl)-N-methyl-N-phenylacetamide (7d) exhibited high binding affinity (Ki = 13.4 nM) with TSPO and moderate lipophilicity (LogD: 1.92). [18F]7d was radiosynthesized by [18F]fluorination of the bromopyridine precursor 7h with [18F]F- at 12 ± 3% radiochemical yield (n = 6, decay-corrected)...
April 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28419799/synthesis-of-protected-3-deoxy-3-fluoro-and-4-deoxy-4-fluoro-d-galactopyranosides-from-levoglucosan
#8
Danny Lainé, Vincent Denavit, Denis Giguère
Fluorinated carbohydrates are invaluable tools to study various biochemical processes. Herein, we describe a new strategy to access orthogonally protected 3-deoxy-3-fluoro- galactopyranose and acetylated 4-deoxy-4-fluoro-galactopyranose. Starting from inexpensive levoglucosan, most reactions were performed on gram scale, allowed excellent regio- and stereocontrol with a minimal use of protection/deprotection cycles. Hence, we developed practical alternatives to the decade-long reported method to access both 3-deoxy-3-fluoro- and 4-deoxy-4-fluoro-galactopyranose...
April 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28419749/novel-19-f-mrs-%C3%AE-galactosidase-reporter-molecules-incorporated-nitrogen-mustard-analogues
#9
Zijun Yu, Jianru Zhao, Zhiming Hua, Xinping Wang, Xiaobo Wang, Hanqin Wang, Jian-Xin Yu
In this paper, we propose a novel molecular platform integrated fluorinated antitumor nitrogen mustards for (19) F-MRS assay of β-galactosidase (β-gal) activity. Following this idea, we have designed, synthesized and characterized 2-fluoro-4-[bis(2'-chloroethyl)amino]phenyl β-D-galactopyranoside 5, 2-fluoro-4-{bis[2'-O-(β-D-galactopyranosyl)ethyl]amino}phenyl β-D-galactopyranoside 8, 2-fluoro-4-{bis[[1''-(β-D-galactopyranosyl)-1'', 2'', 3''-triazol-4''-yl]methyl] amino}phenyl β-D-galactopyranoside 14 and 2-fluoro-4-{bis[[1''-(β-D-glucopyranosyl)-1'', 2'', 3''-triazol-4''-yl]methyl]amino}phenyl β-D-galactopyranoside 15 through glycosylation and click reaction strategies, and their structures were confirmed by NMR and HRMS or elemental analysis data...
April 16, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28418185/cu-pd-synergistic-dual-catalysis-asymmetric-%C3%AE-allylation-of-an-%C3%AE-cf3-amide
#10
Akira Saito, Naoya Kumagai, Masakatsu Shibasaki
Despite the burgeoning demand for fluorine-containing chemical entities, the construction of CF3 -containing stereogenic centers has remained elusive. Herein, we report the strategic merger of Cu(I) /base-catalyzed enolization of an α-CF3 amide and Pd(0) -catalyzed allylic alkylation in an enantioselective manner to deliver chiral building blocks bearing a stereogenic carbon center connected to a CF3 , an amide carbonyl, and a manipulable allylic group. The phosphine complexes of Cu(I) and Pd(0) engage in distinct catalytic roles without ligand scrambling to render the dual catalysis operative to achieve asymmetric α-allylation of the amide...
April 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28418092/atmospheric-chlorinated-polyfluorinated-ether-sulfonate-and-ionic-perfluoroalkyl-acids-in-2006-to-2014-in-dalian-china
#11
Wei Liu, Hui Qin, Jingwen Li, Qian Zhang, Huanhuan Zhang, Zaoshi Wang, Xin He
Chlorinated polyfluorinated ether sulfonate (Cl-PFESA; trade name F-53B) is an alternative product for perfluorooctane sulfonate (PFOS) used in metal plating; little is known about its levels in the environment and its risks. To our knowledge, the present study constitutes the first report of Cl-PFESA in the atmosphere. In 2006 to 2014, C8 Cl-PFESA, along with ionic perfluoroalkyl acids (PFAAs), was detected in atmospheric particulate matter in Dalian, China. Concentrations of C8 Cl-PFESA increased from 140 pg/m(3) in 2007 to 722 pg/m(3) in 2014...
April 18, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28417855/optimization-of-pediatric-pet-ct
#12
REVIEW
Marguerite T Parisi, Mohammed S Bermo, Adam M Alessio, Susan E Sharp, Michael J Gelfand, Barry L Shulkin
PET/CT, the most common form of hybrid imaging, has transformed oncologic imaging and is increasingly being used for nononcologic applications as well. Performing PET/CT in children poses unique challenges. Not only are children more sensitive to the effects of radiation than adults but, following radiation exposure, children have a longer postexposure life expectancy in which to exhibit adverse radiation effects. Both the PET and CT components of the study contribute to the total patient radiation dose, which is one of the most important risks of the study in this population...
May 2017: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/28417636/semi-fluorinated-synergistic-non-fouling-fouling-release-surface
#13
Binbin Xu, Yajing Liu, Xiaowen Sun, Jianhua Hu, Ping Shi, Xiaoyu Huang
The preparation of fluorine-containing synergistic non-fouling/fouling-release surface, using b-PFMA-PEO asymmetric molecular brush possessing both poly(ethylene glycol) (PEO) and poly(2,2,2-trifluoroethyl methacrylate) (PFMA) side chains densely distributed on the same repeated unit along the polymeric backbone, is reported. On the basis of poly(Br-acrylate-alkyne) macro-agent comprising two functionalities (alkynyl and 2-bromopropionate) which is prepared by RAFT homopolymerization of a new trifunctional acrylate monomer of Br-acrylate-alkyne, b-PFMA-PEO asymmetric molecular brushes are obtained by concurrent ATRP and CuAAc "click" reaction in a one-shot system...
April 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28415009/selective-hdac-inhibitors-with-potent-oral-activity-against-leukemia-and-colorectal-cancer-design-structure-activity-relationship-and-anti-tumor-activity-study
#14
Xiaoyang Li, Yingjie Zhang, Yuqi Jiang, Jingde Wu, Elizabeth S Inks, C James Chou, Shuai Gao, Jinning Hou, Qinge Ding, Jingyao Li, Xue Wang, Yongxue Huang, Wenfang Xu
Previously, we reported the discovery of a series of N-hydroxycinnamamide-based HDAC inhibitors, among which compound 11y exhibited high HDAC1/3 selectivity. In this current study, structural derivatization of 11y led to a new series of benzamide based HDAC inhibitors. Most of the compounds exhibited high HDACs inhibitory potency. Compound 11a (with 4-methoxybenzoyl as N-substituent in the cap and 4-(aminomethyl) benzoyl as the linker group) exhibited selectivity against HDAC1 to some extent, and showed potent antiproliferative activity against several tumor cell lines...
March 30, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28414423/robust-fluorine-free-superhydrophobic-amino-silicone-oil-sio2-modification-of-electrospun-polyacrylonitrile-membranes-for-waterproof-breathable-application
#15
Junlu Sheng, Yue Xu, Jianyong Yu, Bin Ding
Superhydrophobic waterproof-breathable membranes have attracted considerable interest owing to their multifunctional applications in self-cleaning, anti-icing, anticorrosion, outdoor tents, and protective clothing. Despite the researches pertaning to the construction of superhydrophobic functional membranes by nanoparticle finishing have increased drastically, the disconnected particle component is easy to fall off from the membranes under deformation and wear conditions, which has restricted their wide use in practice...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28413749/targeted-fluoro-positioning-for-the-discovery-of-a-potent-and-highly-selective-matrix-metalloproteinase-inhibitor
#16
Thomas Fischer, Rainer Riedl
The incorporation of fluorine atoms into functional molecules is of wide interest in synthetic organic chemistry as well as cognate disciplines. In particular, in medicinal chemistry, there is a strong desire to positively influence the physicochemical molecular properties of drug compounds by introducing fluorine into biologically active molecules. Here, we present targeted fluoro positioning as the key design principle of converting a weak matrix metalloproteinase-13 (MMP-13) inhibitor into a very potent (IC50=6 nm) and highly selective (selectivity factors of >1000 over MMP-1, 2, 3, 7, 8, 9, 10, 12, 14) inhibitor with excellent plasma and microsomal stability, and no binding to the hERG channel (hERG: human ether-a-go-go related gene)...
April 2017: ChemistryOpen
https://www.readbyqxmd.com/read/28413258/fluorinated-polyurethane-scaffolds-for-19-f-magnetic-resonance-imaging
#17
Twan Lammers, Marianne E Mertens, Philipp Schuster, Khosrow Rahimi, Yang Shi, Volkmar Schulz, Alexander J C Kuehne, Stefan Jockenhoevel, Fabian Kiessling
Polymers are increasingly employed in implant materials. To reduce the incidence of complications, which in the case of vascular grafts include incorrect placement and restenosis, materials are needed which allow for image-guided implantation, as well as for accurate and efficient postoperative implant imaging. We here describe amorphous fluorinated polymers based on thermoplastic polyurethane ((19)F-TPU), and show that are useful starting materials for developing tissue-engineered vascular grafts which can be detected using (19)F MRI...
April 11, 2017: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/28411455/identification-of-3-substituted-6-1-1h-1-2-3-triazolo-4-5-b-pyrazin-1-yl-ethyl-quinoline-derivatives-as-highly-potent-and-selective-mesenchymal-epithelial-transition-factor-c-met-inhibitors-via-metabolite-profiling-based-structural-optimization
#18
Fei Zhao, Le-Duo Zhang, Yu Hao, Na Chen, Rui Bai, Yu-Ji Wang, Chun-Chun Zhang, Gong-Sheng Li, Li-Jun Hao, Chen Shi, Jing Zhang, Yu Mao, Yi Fan, Guang-Xin Xia, Jian-Xin Yu, Yan-Jun Liu
c-Met/HGF signaling pathway plays an important role in cancer progression, and it was considered to be related to poor prognosis and drug resistance. Based on metabolite profiling of (S)-7-fluoro-6-(1-(6-(1-methyl-1H-pyrazol-4-yl)-1H-imidazo[4,5-b]pyrazin-1-yl)ethyl)quinoline (1), a series of 2-substituted or 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives was rationally designed and evaluated. Most of the 3-substituted derivatives not only exhibited potent activities in both enzymatic and cellular assays, but also were stable in liver microsomes among different species (human, rat and monkey)...
April 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28410488/understanding-the-potency-of-fatty-acids-with-the-amino-acid-side-chains-of-bovine-%C3%AE-lactoglobulin-a-quantum-chemical-approach
#19
Deepa Palanisamy, B Vijaya Pandiyan, Thirumeignanam Duraisamy, Ponmalai Kolandaivel
The present study aims to spotlight on the strength of interaction between different fatty acids with the Bovine-lactoglobulin (LGB) protein side chains along with the crystal water molecules at M062X/def2-QZVP level of theory. To analyse the role of carboxylic acid and its interaction with side chains and to reveal the significance of carboxylic acid, it was replaced by Acyl chloride (COCl), Acyl Bromide (COBr) and Acyl-Fluorine (COF) group and COS group. The ligands are linear with a straight and branched chain of carbon atoms, but extended methyl group make the ligand bend resulting in non-planar geometry...
March 22, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28410290/diagnostic-and-prognostic-impact-of-fluorine-18-fluorodeoxyglucose-pet-ct-in-preoperative-and-postoperative-setting-of-breast-cancer-patients
#20
Laura Evangelista, Anna R Cervino, Silvia Michieletto, Tania Saibene, Cristina Ghiotto, Valentina Guarneri, Pierfranco Conte, Pasquale Reccia, Giorgio Saladini
PURPOSE: The aim of this study was to assess the diagnostic and prognostic value of fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT in patients with breast cancer (BC) in the preoperative and the postoperative setting. PATIENTS AND METHODS: Between 2011 and 2015, we prospectively enrolled 275 patients (mean age: 53 years) with BC (stage I-III; triple-negative or HER2-positive cancer). One-hundred and forty-nine (54.2%) patients underwent F-FDG PET/CT before neoadjuvant therapy and 126 (45...
April 13, 2017: Nuclear Medicine Communications
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