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Luis Angel Hernandez-Arenas, Rushmi D Purmessur, Diego Gonzalez-Rivas
Uniportal video-assisted thoracoscopic surgery (VATS) segmentectomy is a technically more complex procedure than uniportal VATS lobectomy, since a detailed comprehension of the segmental anatomy is required. Anatomic sublobar resection can achieve outcomes equivalent to lobectomy in selected patients with stage IA non-small cell lung carcinoma (NSCLC). In this paper we describe our clinical experiences and introduce the technical details of uniportal VATS segmentectomy, including expertise advice ("tips and tricks") in patient selection, positioning and incisions and technical highlights of the most common types of segmentectomies...
April 2018: Journal of Thoracic Disease
Sameer A Hirji, Scott J Swanson
Contemporary management of early stage non-small cell lung cancer (NSCLC) is evolving and can be attributed to a change in size and histology of lung cancer, advancements in imaging modalities, instrumentation and surgical techniques. The emergence of segmentectomy has further challenged the existing treatment landscape, with promising results. Despite limited widespread adoption, video-assisted thoracoscopic surgery (VATS) segmentectomy is a safe option in the treatment of patients with small stage I lung cancers, with excellent oncologic results and improved morbidity relative to open techniques...
April 2018: Journal of Thoracic Disease
Bin Tian, Shyamal K Talukder, Jianming Fu, Allan K Fritz, Harold N Trick
Wheat ( Triticum aestivum L.) is a temperate cereal with an optimum temperature range of 15-22°C during the grain filling stage. Heat stress is one of the major environmental constraints for wheat production worldwide. Temperatures above 25°C during the grain filling stage significantly reduced wheat yield and quality. This reduction was reported due to the inactivation of the soluble starch synthase, a key heat-labile enzyme in starch transformation of wheat endosperm. To improve wheat productivity under heat stress, the rice soluble starch synthase I, under the control of either a constitutive promoter or an endosperm-specific promoter, was expressed in wheat and the transgenic lines were monitored for expression and the effects on yield-related traits...
2018: In Vitro Cellular & Developmental Biology. Plant: Journal of the Tissue Culture Association
Dana A Davis
Endoplasmic reticulum (ER)-mitochondria tethering by the ERMES complex is critical for numerous mitochondrial functions in fungi. It was recently discovered that the GTPase Arf1, which regulates within Golgi vesicular trafficking also affects ER-mitochondrial tethering potentially through ERMES. In Candida albicans, Arf1 not only functions in vesicular trafficking and affects ERMES but also impacts reactive oxygen species generation, which is a key immune defense molecule.
May 15, 2018: FEBS Journal
Pier Cristoforo Giulianotti, Alberto Mangano, Roberto E Bustos, Federico Gheza, Eduardo Fernandes, Mario A Masrur, Antonio Gangemi, Francesco M Bianco
BACKGROUND: Minimally invasive pancreaticoduodenectomy (MIPD) was introduced in the attempt to improve the outcomes of the open approach. Laparoscopic pancreaticoduodenectomy (LPD) was first reported by Gagner and Pomp (Surg Endosc 8:408-410, 1994). Unfortunately, due to its complexity and technical demand, LPD never reached widespread popularity. Since it was first performed by P. C. Giulianotti in 2001, Robotic PD (RPD) has been gaining ground among surgeons. MIPD is included as a surgical option in the latest NCCN Guidelines...
May 15, 2018: Surgical Endoscopy
Jennifer Geddes-McAlister, Rebecca S Shapiro
Fungal pathogens are a growing threat to public health. As human immunodeficiency becomes increasingly common, fungal infections are becoming more prevalent. The use of antifungal agents for prophylaxis and treatment of fungal infections has favored the emergence of previously rare or unidentified species of drug-resistant fungal pathogens, including several Candida and Cryptococcus species, as well as mold pathogens. As these new and increasingly drug-resistant fungal pathogens continue to emerge, novel strategies for rapid identification and treatment are necessary to combat these life-threatening infections...
May 15, 2018: Annals of the New York Academy of Sciences
A M Piekarska, T K Kopeć
We study disordered interacting bosons described by the Bose-Hubbard model with Gaussian-distributed random tunneling amplitudes. It is shown that the off-diagonal disorder induces a spin-glass-like ground state, characterized by randomly frozen quantum-mechanical U(1) phases of bosons. To access criticality, we employ the "n-replica trick," as in the spin-glass theory, and the Trotter-Suzuki method for decomposition of the statistical density operator, along with numerical calculations. The interplay between disorder, quantum, and thermal fluctuations leads to phase diagrams exhibiting a glassy state of bosons, which are studied as a function of model parameters...
April 20, 2018: Physical Review Letters
Cheng B Saw, Sicong Li
Three-dimensional (3D) treatment planning systems have evolved and become crucial components of modern radiation therapy. The systems are computer-aided designing or planning softwares that speed up the treatment planning processes to arrive at the best dose plans for the patients undergoing radiation therapy. Furthermore, the systems provide new technology to solve problems that would not have been considered without the use of computers such as conformal radiation therapy (CRT), intensity-modulated radiation therapy (IMRT), and volumetric modulated arc therapy (VMAT)...
July 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Wachirun Terakosolphan, Jemma L Trick, Paul G Royall, Sarah E Rogers, Olimpia Lamberti, Christian D Lorenz, Ben Forbes, Richard D Harvey
The inclusion of glycerol in formulations for pulmonary drug delivery may affect the bioavailability of inhaled steroids by retarding their transport across the lung epithelium. The aim of this study was to evaluate whether the molecular interactions of glycerol with model pulmonary interfaces provide a biophysical basis for glycerol modifying inhaled drug transport. Dipalmitoylphosphatidylcholine (DPPC) monolayers and liposomes were used as model pulmonary interfaces, in order to examine the effects of bulk glycerol (0 - 30% w/w) on their structures and dynamics using complementary biophysical measurements and molecular dynamics (MD) simulations...
May 8, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Suet-Lai Cheng, Chung-Ming Chu
Electromagnetic navigation bronchoscopy (ENB) is gaining acceptance and popularity amongst bronchoscopists as one of the tools to diagnose pulmonary nodules (PNs). Although the majority of ENBs in earlier studies were performed under general anaesthesia (GA), later reports suggest that the diagnostic yield of ENB under intravenous sedation (IVS) was comparable, and was time saving. ENB under IVS may potentially improve access of the techniques to practitioners and patients. However, it is technically challenging when compared to its performance under GA...
April 2018: Journal of Thoracic Disease
Kazuya Yoshida
OBJECTIVES: Oromandibular dystonia, which is characterized by stereotypic, task-specific, or sustained contractions of masticatory and/or lingual muscles, is frequently misdiagnosed as temporomandibular disorders or psychogenic disease. Diagnostic delay in oromandibular dystonia is not acceptable; thus, a screening tool that can distinguish this condition from a temporomandibular disorder may be helpful for medical professionals unfamiliar with involuntary movements or temporomandibular disorders...
May 2, 2018: Clinical Oral Investigations
Marios G Lykissas, Dionysios Giannoulis
During the last two decades, minimally invasive techniques and instruments in spine surgery have undergone serious development in all fields. Specific advantages of these minimally invasive methods have put them forward in spine surgery in recent times. Preservation of important anatomical structures of the spine is a major factor for the evolution of these procedures. The lower prevalence of complications and faster rehabilitation of patients are some of the advantages of minimally invasive spine surgery (MISS)...
March 2018: Annals of Translational Medicine
Jaume Baguñà
Scientific fields grow by accretion of knowledge brought up by succesive generations of scientists. With the field of planarian regeneration as a general background, here I give a personal account of it from the late 1960s until the late 1990s when new research groups, namely Americans, broke into it. After a short historical summary, I report how I got into regeneration, why I choose planarians, and most especially the finding and description of the current model organism Schmidtea mediterranea. Next, I concentrate on the quantitative cellular approaches to regeneration, growth, and degrowth undertaken in our lab in Barcelona, and the long struggle to set neoblasts as a totipotent/pluripotent heterogeneous population of mitotic and non-mitotic cells for homeostatic somatic cell renewal, reproduction, and blastema formation during regeneration...
April 26, 2018: Seminars in Cell & Developmental Biology
Juan D Garisto, Julien Dagenais, Hans Arora, Riccardo Bertolo, Jihad Kaouk
No abstract text is available yet for this article.
April 25, 2018: Urology
Oya Öztürk, Ayşegül Gündüz, Meral E Kızıltan
OBJECTIVE: In healthy subjects, magnitude of hand-evoked blink reflex (BR) is increased if the stimulated hand is positioned in the peripersonal space. Here, we aimed to investigate the modulation of hand-evoked BR in peripersonal space to understand alterations of cortical modulations of subcortical structures in cervical dystonia. PATIENTS AND METHOD: We recruited 23 patients with idiopathic cervical dystonia and 21 healthy subjects, all of whom had hand-evoked BR...
April 25, 2018: Neuroscience Letters
William E Trick, Stephen J Sokalski, Stuart Johnson, Kristen L Bunnell, Joseph Levato, Michael J Ray, Robert A Weinstein
OBJECTIVETo evaluate probiotics for the primary prevention of Clostridium difficile infection (CDI) among hospital inpatients.DESIGNA before-and-after quality improvement intervention comparing 12-month baseline and intervention periods.SETTINGA 694-bed teaching hospital.INTERVENTIONWe administered a multispecies probiotic comprising L. acidophilus (CL1285), L. casei (LBC80R), and L. rhamnosus (CLR2) to eligible antibiotic recipients within 12 hours of initial antibiotic receipt through 5 days after final dose...
April 26, 2018: Infection Control and Hospital Epidemiology
Stephen M Vindigni, Christina M Surawicz
No abstract text is available yet for this article.
April 24, 2018: American Journal of Gastroenterology
Helena Esteban Cuesta, José Martel Villagran, Angel Bueno Horcajadas, Ara Kassarjian, Gil Rodriguez Caravaca
OBJECTIVES: To define specific characteristics of osteoid osteomas treated with radiofrequency ablation, that may benefit from special technical recommendations. METHODS: Retrospective analysis of all radiofrequency ablations performed by our group from January 2001 to March 2015. A descriptive study was conducted. We compared our results with the available literature to determine the most frequent special scenarios. RESULTS: 207 radiofrequency ablations were performed in 200 patients...
May 2018: European Journal of Radiology
Xuefei Yang, Li Jiang, Yue Li, Jingsi Liu, Joe King-Man Fan
Laparoscopic repair of ventral incisional hernia with intraperitoneal onlay mesh (IPOM) technique by anti-adhesion mesh has been widely adopted. Due to clinical heterogenicity in location, quantity and size of abdominal incisional hernia, strategy of such repair can be challenging. We hereby present the video of a patient with multiple swiss-cheese hernias in a single long midline incision repaired with double anti-adhesion mesh by IPOM technique. Patient demographics, technical details and clinical tips & tricks are discussed...
2018: Journal of Visualized Surgery
Cyril Thomas, André Didierjean, Gustav Kuhn
When faced with a difficult question, people sometimes work out an answer to a related, easier question without realizing that a substitution has taken place (e.g., Kahneman, 2011, Thinking, fast and slow. New York, Farrar, Strauss, Giroux). In two experiments, we investigated whether this attribute substitution effect can also affect the interpretation of a simple visual event sequence. We used a magic trick called the 'Flushtration Count Illusion', which involves a technique used by magicians to give the illusion of having seen multiple cards with identical backs, when in fact only the back of one card (the bottom card) is repeatedly shown...
April 17, 2018: British Journal of Psychology
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