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https://www.readbyqxmd.com/read/28932577/how-to-design-a-randomized-clinical-trial-tips-and-tricks-for-conduct-a-successful-study-in-thoracic-disease-domain
#1
Francesco Guerrera, Stéphane Renaud, Fabrizio Tabbò, Pier Luigi Filosso
Randomized controlled trials (RCTs) are considered one of the highest level of evidence in clinical practice, due to their strong confidence and robustness in producing data. The "randomization" (e.g., allocating patients randomly in each group of the study) allows eliminating many pre-analytical differences that might bias the entire study. Nevertheless, RCTs aren't free of internal pitfalls that might make them not easy to be developed or utilized. Our objective is to explain RCT management difficulties and suggest certain tips useful for the design of a RCT in thoracic disease domain...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28931554/new-tricks-for-nrf2-therapeutic-targeting-to-restore-bk-%C3%AE-1-expression
#2
Sarah J Chapple, Giovanni E Mann
No abstract text is available yet for this article.
October 2017: Diabetes
https://www.readbyqxmd.com/read/28930923/neuroimaging-of-vagal-nerve-stimulation-are-we-missing-a-trick
#3
James K Ruffle, Qasim Aziz, Adam D Farmer
No abstract text is available yet for this article.
October 2017: Pain
https://www.readbyqxmd.com/read/28929348/-comparative-analysis-of-light-sensitivity-depth-and-motion-perception-in-animals-and-humans
#4
REVIEW
F Schaeffel
BACKGROUND: This study examined how humans perform regarding light sensitivity, depth perception and motion vision in comparison to various animals. OBJECTIVE: The parameters that limit the performance of the visual system for these different functions were examined. METHODS: This study was based on literature studies (search in PubMed) and own results. RESULTS: Light sensitivity is limited by the brightness of the retinal image, which in turn is determined by the f‑number of the eye...
September 19, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28923238/old-drug-new-tricks-reducing-cough-in-ipf
#5
Stuart B Mazzone
No abstract text is available yet for this article.
September 8, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28913870/mimicry-in-butterflies-co-option-and-a-bag-of-magnificent-developmental-genetic-tricks
#6
REVIEW
Riddhi Deshmukh, Saurav Baral, A Gandhimathi, Muktai Kuwalekar, Krushnamegh Kunte
Butterfly wing patterns are key adaptations that are controlled by remarkable developmental and genetic mechanisms that facilitate rapid evolutionary change. With swift advancements in the fields of genomics and genetic manipulations, identifying the regulators of wing development and mimetic wing patterns has become feasible even in nonmodel organisms such as butterflies. Recent mapping and gene expression studies have identified single switch loci of major effects such as transcription factors and supergenes as the main drivers of adaptive evolution of mimetic and polymorphic butterfly wing patterns...
September 14, 2017: Wiley Interdisciplinary Reviews. Developmental Biology
https://www.readbyqxmd.com/read/28913685/-ramp-lesions-tips-and-tricks-in-diagnostics-and-therapy
#7
REVIEW
R Seil, A Hoffmann, S Scheffler, D Theisen, C Mouton, D Pape
There is an increasing biomechanical and anatomical understanding of the different types of meniscal lesions. Lesions of the posterior part of the medial meniscus in the meniscosynovial area have recently received increased attention. They generally occur in association with anterior cruciate ligament (ACL) injuries. They are often missed ("hidden lesions") due to the fact that they cannot be seen by routine anterior arthroscopic inspection. Furthermore, meniscosynovial lesions play a role in anteroposterior knee laxity and, as such, they may be a cause of failure of ACL reconstruction or of postoperative persistent laxity...
September 14, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28905007/reconstruction-after-laparoscopic-assisted-distal-gastrectomy-technical-tips-and-pitfalls
#8
REVIEW
Zirui He, Lu Zang
After the advent of the concept of laparoscopic assisted distal gastrectomy (LADG), the digestive reconstruction poses arguments among surgeons. There are three major different ways including Billroth I gastroduodenostomy, Billroth II gastrojejunostomy and Roux-en-Y gastrojejunostomy, and each of them has its own trick. In this article, the technical tips and pitfalls of each reconstruction will be discussed based on studies and author's experience.
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28904903/vasectomy-tips-and-tricks
#9
REVIEW
Dane Johnson, Jay I Sandlow
According to data from the National Study of Family Growth, vasectomy is utilized by 6-13% of American couples for their form of contraception. Physician surveys have shown that over 500,000 men undergo vasectomies per year, and more than 75% of vasectomies are performed by urologists. This chapter provides a brief history of vasectomy, as well as recommendations for preoperative counseling, an overview of the modified no-scalpel vasectomy technique, and a brief description of the complications of vasectomy...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28904897/peyronie-s-graft-surgery-tips-and-tricks-from-the-masters-in-andrologic-surgery
#10
Georgios Hatzichristodoulou, Peter Tsambarlis, Hubert Kübler, Laurence A Levine
BACKGROUND: Grafting techniques in the surgical management of Peyronie's disease (PD) are challenging, especially in inexperienced hands. In order to improve surgical outcomes the urologist should follow a standard surgical approach, preferably of an established and reliable grafting technique. The aim of this study is to provide tips and tricks for graft surgery for PD. METHODS: This report offers a step-by-step tutorial for grafting techniques in PD, especially for the Sealing technique and the partial plaque excision and grafting (PEG) procedure...
August 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28904446/levodopa-history-and-therapeutic-applications
#11
Sujith Ovallath, Bahiya Sulthana
Levodopa - the aromatic amino acid L-3,4-dihydroxy phenylalanine has held the attention of neurologists and pharmacologists alike for more than half a century. Even though extensive research has been done across the globe in treatment of Parkinson's disease, with different molecules, none could replace the gold standard treatment or provide complete relief for the debilitated. Although research brought us better tips and tricks to modulate the dopamine blood levels to balance between the desired and deleterious effects, it could never replace the basic substrate...
July 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28902608/technique-tricks-for-the-gleich-koutsogiannis-surgical-procedure-for-correction-of-the-adult-acquired-flatfoot
#12
Andrea Salvi, Andrea Volghi
Gleich-Koutsogiannis is a widely known extra-articular closing calcaneal osteotomic technique for correction of the adult flatfoot. Absolute care must be observed during each procedural step to avoid undesirable drawbacks, such as nerves and tendons lesions, incorrect fixation, and hardware painful prominence. It is the purpose of this report to introduce tricks to critical steps in order to improve the technique and minimize potential surgical complications.
May 2017: Bulletin of the Hospital for Joint Diseases
https://www.readbyqxmd.com/read/28901199/new-tricks-for-the-glycyl-radical-enzyme-family
#13
Lindsey R F Backman, Michael A Funk, Christopher D Dawson, Catherine L Drennan
Glycyl radical enzymes (GREs) are important biological catalysts in both strict and facultative anaerobes, playing key roles both in the human microbiota and in the environment. GREs contain a backbone glycyl radical that is post-translationally installed, enabling radical-based mechanisms. GREs function in several metabolic pathways including mixed acid fermentation, ribonucleotide reduction and the anaerobic breakdown of the nutrient choline and the pollutant toluene. By generating a substrate-based radical species within the active site, GREs enable C-C, C-O and C-N bond breaking and formation steps that are otherwise challenging for nonradical enzymes...
September 13, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28895256/relevant-anatomy-morphology-and-implantation-techniques-of-the-dorsal-root-ganglia-at-the-lumbar-levels
#14
Tim Vancamp, Robert M Levy, Isaac Peña, Antonio Pajuelo
OBJECTIVES: While dorsal root ganglion (DRG) stimulation has been available in Europe and Australia for the past five years and in the United States for the past year, there are no published details concerning the optimal procedures for DRG lead implantation. MATERIALS AND METHODS: We describe several techniques that can be applied to implant cylindrical leads over the DRG, highlighting some tips and tricks according to our experiences. Focus is mainly shifted toward implantations in the lumbar area...
September 12, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28893976/teaching-an-old-drug-new-tricks-agonism-antagonism-and-biased-signaling-of-pilocarpine-through-m3-muscarinic-acetylcholine-receptor
#15
Alexey Pronin, Qiang Wang, Vladlen Z Slepak
Pilocarpine is a prototypical drug used to treat glaucoma and dry mouth and classified as either a full or partial muscarinic agonist. Here, we report several unexpected results pertaining to its interaction with muscarinic M3 receptor (M3R). We found that pilocarpine was 1,000 times less potent in stimulating mouse eye pupil constriction than muscarinic agonists oxotremorin-M (Oxo-M) or carbachol (CCh), even though all three ligands have similar Kd values for M3R. In contrast to CCh or Oxo-M, pilocarpine does not induce Ca2+ mobilization via endogenous M3R in HEK293T or mouse insulinoma MIN6 cells...
September 11, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28887238/emergent-carotid-stent-removal-after-carotid-stent-thrombosis-surgical-technique
#16
Konstantinos G Moulakakis, Andreas Lazaris
OBJECTIVE: To present the technique for emergent removal of the thrombosed stent in acute carotid stent thrombosis in patients undergoing carotid artery angioplasty-stenting (CAS) BACKGROUND: Acute carotid stent thrombosis in patients undergoing CAS is a relatively rare and potentially devastating complication influencing significantly the quality of life. With the increasing use of stenting in clinical practice, it is expected to represent a more often encountered complication for physicians performing CAS...
September 5, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28885059/viral-deubiquitinases-role-in-evasion-of-anti-viral-innate-immunity
#17
Puja Kumari, Himanshu Kumar
Host anti-viral innate-immune signalling pathways are regulated by a variety of post-translation modifications including ubiquitination, which is critical to regulate various signalling pathways for synthesis of anti-viral molecules. A homeostasis of host immune responses, induced due to viral infection and further ubiquitination, is maintained by the action of deubiquitinases (DUB). Infecting viruses utilize the process of deubiquitination for tricking host immune system wherein viral DUBs compete with host DUBs for inhibition of innate-immune anti-viral signalling pathways, which instead of maintaining an immune homeostasis bring about virus-mediated pathogenesis...
September 8, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28882920/the-hat-trick-programme-for-improving-physical-activity-healthy-eating-and-connectedness-among-overweight-inactive-men-study-protocol-of-a-pragmatic-feasibility-trial
#18
Cristina M Caperchione, Joan L Bottorff, John L Oliffe, Steven T Johnson, Kate Hunt, Paul Sharp, Kayla M Fitzpatrick, Ryley Price, S Larry Goldenberg
INTRODUCTION: Physical activity, healthy eating and maintaining a healthy weight are associated with reduced risk of cardiovascular disease, type 2 diabetes and cancer and with improved mental health. Despite these benefits, many men do not meet recommended physical activity guidelines and have poor eating behaviours. Many health promotion programmes hold little appeal to men and consequently fail to influence men's health practices. HAT TRICK was designed as a 12-week face-to-face, gender-sensitised intervention for overweight and inactive men focusing on physical activity, healthy eating and social connectedness and was delivered in collaboration with a major junior Canadian ice hockey team (age range 16-20 years)...
September 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28882198/genetic-biochemical-and-biophysical-methods-for-studying-fes-proteins-and-their-assembly
#19
Sandrine Ollagnier de Choudens, Frédéric Barras
FeS clusters containing proteins are structurally and functionally diverse and present in most organisms. Our understanding of FeS cluster production and insertion into polypeptides has benefited from collaborative efforts between in vitro and in vivo studies. The former allows a detailed description of FeS-containing protein and a deep understanding of the molecular mechanisms catalyzing FeS cluster assembly. The second allows to include metabolic and environmental constraints within the analysis of FeS homeostasis...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28879369/surgical-tricks-for-open-lumbar-discectomy
#20
Cesare Faldini, Fabrizio Perna, Mohammadreza Chehrassan, Raffaele Borghi, Niccolò Stefanini, Francesco Traina
No abstract text is available yet for this article.
September 6, 2017: European Spine Journal
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