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https://www.readbyqxmd.com/read/28343147/ethical-ramifications-of-the-paolo-macchiarini-case
#1
Jaime A Teixeira da Silva
The Paolo Macchiarini case has several ethical ramifications. Professor Macchiarini, formerly of the Karolinska Institutet (KI), became famous for the tracheal surgeries he conducted between 2008 and 2014. His rapid rise to fame was followed by an almost equally rapid fall from grace as official reports, articles in newspapers and television programmes revealed several aspects related to misconduct in his curriculum vitae, professional practices and publishing-related activity. Formal misconduct reports issued by four KI co-workers in late 2014, then again in 2016, coupled with social scandals, including the tricking of a famous US television newscaster into a false marriage, a previous arrest in Italy for apparent bribery, and acute narcissism, all tainted Macchiarini's legend...
March 15, 2017: Indian Journal of Medical Ethics
https://www.readbyqxmd.com/read/28338306/implantation-of-a-biodegradable-rectum-balloon-implant-tips-tricks-and-pitfalls
#2
Ben G L Vanneste, Kees van De Beek, Ludy Lutgens, Philippe Lambin
INTRODUCTION: A rectum balloon implant (RBI) is a new device to spare rectal structures during prostate cancer radiotherapy. The theoretical advantages of a RBI are to reduce the high radiation dose to the anterior rectum wall, the possibility of a post-implant correction, and their predetermined shape with consequent predictable position. OBJECTIVE: To describe, step-by-step, our mini-invasive technique for hands-free transperineal implantation of a RBI before start of radiotherapy treatment...
March 24, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28336448/permanent-implants-for-lip-augmentation-results-from-a-retrospective-study-and-presentation-of-tips-and-tricks
#3
S Guida, V D Mandel, F Farnetani, C M Manola, G Rubino, S Ruzzu, G Pellacani, C Longo, G G Urtis
BACKGROUND: Requests for lip augmentation are increasing because of expanding media exposure and consumer needs. Temporary effects can be obtained by several techniques, but a recent procedure consisting of lip prosthesis implantation, offering a permanent result, is emerging. Accordingly, the implantation of solid lip prosthesis represents an innovation in the field of esthetic medicine and surgery. METHODS: A total of 100 women with atrophic or hypoplastic lips were treated with lip implants...
February 27, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28331258/tricking-a-cancer-cell-into-committing-suicide-or-apoptosis
#4
EDITORIAL
Chintamani
No abstract text is available yet for this article.
February 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28315262/a-review-of-the-human-sigma-1-receptor-structure
#5
Felipe Ossa, Jason R Schnell, José Luis Ortega-Roldan
The Sigma-1 Receptor (S1R) is a small, ligand-regulated integral membrane protein involved in cell homeostasis and the cellular stress response. The receptor has a multitude of protein and small molecule interaction partners with therapeutic potential. Newly reported structures of the human S1R in ligand-bound states provides essential insights into small molecule binding in the context of the overall protein structure. The structure also raises many interesting questions and provides an excellent starting point for understanding the molecular tricks employed by this small membrane receptor to modulate a large number of signaling events...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28315177/physical-symptoms-screening-for-cardiopulmonary-complications-of-obesity-using-audio-computer-assisted-self-interviews
#6
Jorge L Morales-Estrella, Farah D Ciftci, William E Trick, Keiki Hinami
PURPOSE: The main study objective was to assess the predictive value of selected physical symptoms for screening obstructive sleep apnea and major cardiac conditions in adults with obesity, thus providing the evidence for routine symptom screening of obesity complications endorsed by obesity management clinical practice guidelines. METHODS: We performed a retrospective cohort study using patient-reported outcomes data including the physical symptoms severity component of the Memorial Symptom Assessment Scale administered through Audio Computer-Assisted Self-Interviews combined with data from the electronic medical records of an urban safety-net primary care clinic...
March 17, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28301628/recurrent-herpes-labialis-in-adults-new-tricks-for-an-old-dog
#7
Ted Rosen
<p>Herpes labialis remains a common worldwide affliction. Recent advances in understanding the basic pathogenesis have led to new therapeutic intervention, both on-label and off-label. Aside from reducing the duration and symptomatology of acute outbreaks, another goal of treatment is to decrease the frequency of future episodes. Oral and topical acyclovir and its analogues are the mainstay of both chronic suppressive and episodic therapy. A new muco-adhesive formulation of acyclovir provides a decrease in outbreaks, probably due to a diminution of herpesvirus load in all reservoir sites...
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28293836/plant-ethylene-detection-using-laser-based-photo-acoustic-spectroscopy
#8
Bram Van de Poel, Dominique Van Der Straeten
Analytical detection of the plant hormone ethylene is an important prerequisite in physiological studies. Real-time and super sensitive detection of trace amounts of ethylene gas is possible using laser-based photo-acoustic spectroscopy. This Chapter will provide some background on the technique, compare it with conventional gas chromatography, and provide a detailed user-friendly hand-out on how to operate the machine and the software. In addition, this Chapter provides some tips and tricks for designing and performing physiological experiments suited for ethylene detection with laser-based photo-acoustic spectroscopy...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28293544/induction-of-atypical-autophagy-by-porcine-hemagglutinating-encephalomyelitis-virus-contributes-to-viral-replication
#9
Ning Ding, Kui Zhao, Yungang Lan, Zi Li, Xiaoling Lv, Jingjing Su, Huijun Lu, Feng Gao, Wenqi He
Autophagy is a basic biological metabolic process involving in intracellular membrane transport pathways that recycle cellular components and eliminate intracellular microorganisms within the lysosome. Autophagy also plays an important part in virus infection and propagation. However, some pathogens, including viruses, have evolved unique trick to escape or exploit autophagy. This study explores the mechanism of autophagy induction by porcine hemagglutinating encephalomyelitis virus (PHEV) in Neuro-2a cells, and examines the role of autophagy in PHEV replication...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28292857/awake1-an-abc-type-transporter-reveals-an-essential-role-for-suberin-in-the-control-of-seed-dormancy
#10
Fabio Fedi, Carmel O'Neil, Guillaume Menard, Martin Trick, Francoise Corbineau, Christophe Bailly, Peter J Eastmond, Steven Penfield
The mother plant plays an important dynamic role in the control of dormancy of her progeny seed, in response to environmental signals. In order to further understand the mechanisms by which this dormancy control takes place we conducted a forward genetic screen to isolate mutants which fail to enter dormancy in response to variation in temperature during seed set. We show that for the first of these mutants, designated AWAKE1, the maternal allele is required for entry into strongly dormant states, and that awake1 mutants show seed phenotypes previously shown to be associated with loss of suberin the seed...
March 14, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28287957/algebraic-clustering-of-affine-subspaces
#11
Manolis Tsakiris, Rene Vidal
Subspace clustering is an important problem in machine learning with many applications in computer vision and pattern recognition. Prior work has studied this problem using algebraic, iterative, statistical, low-rank and sparse representation techniques. While these methods have been applied to both linear and affine subspaces, theoretical results have only been established in the case of linear subspaces. For example, algebraic subspace clustering (ASC) is guaranteed to provide the correct clustering when the data points are in general position and the union of subspaces is transversal...
March 6, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28285851/ivermectin-old-drug-new-tricks
#12
REVIEW
Roz Laing, Victoria Gillan, Eileen Devaney
Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery. Although best described for its activity on glutamate-gated chloride channels in parasitic nematodes, understanding of its mode of action remains incomplete. In the field of veterinary medicine, resistance to ivermectin is now widespread, but the mechanisms underlying resistance are unresolved...
March 9, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28283229/new-tricks-for-old-dogs
#13
EDITORIAL
James Jaggers
No abstract text is available yet for this article.
February 8, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28280688/management-of-anastomosis-leakage-post-ralp-a-simple-trick-for-a-complex-situation
#14
Romain Diamand, Walid Al Hajj Obeid, Anna Accarain, Ksenija Limani, Eric Hawaux, Roland van Velthoven, Alexandre Peltier
A case of 74 years old male patient who underwent RALP with bladder neck reconstruction. Persistent vesicourethral anastomotic leak was seen at cystography. A self-made side fenestrated Foley catheter was used and on the day after, a complete reversal in fluid output between the Foley catheter and the drain was seen.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28278128/cancer-metastasis-tricks-of-the-trade
#15
REVIEW
Rabia Zeeshan, Zeeshan Mutahir
Decades of cancer research have unraveled genetic, epigenetic and molecular pathways leading to plausible therapeutic targets; many of which hold great promise in improving clinical outcomes. Metastatic tumors become evident early on and are one of the major causes of cancer-related fatalities worldwide. This review depicts the sequential events of cancer metastasis. Genetic and epigenetic heterogeneity influences local tumor cell invasion, intravasation, survival in circulation, extravasation and colonization to distant sites...
March 9, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28272029/intraoperative-continuous-intestinal-loop-warming-technique-a-prospective-randomised-trial
#16
Francesco Rulli, Mario Stefani, Myftar Torba, Arvin Dibra, Erina Alushi, Filadelfo Coniglione, Mostafa Shalaby, Pierpaolo Sileri
AIM: The aim of this study is to evaluate if the Intraoperative Continuous Intestinal Loop Warming (ICLW) is a valid trick to decrease the postoperative paralytic ileus. METHODS: The subjects were patients who underwent emergency open abdominal surgery for either benign or malignant diseases. Patients were divided into two groups; group A patients who was secluded for ICLW, and a control group B who was not secluded for ICLW. The primary outcomes were the time of recovery of bowel movement, 30 days postoperative mortality and morbidity, morbidity was graded by the Clavien-Dindo classification of surgical complications...
March 8, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28259385/kshv-micrornas-tricks-of-the-devil
#17
REVIEW
Jie Qin, Wan Li, Shou-Jiang Gao, Chun Lu
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a vascular tumor frequently found in immunodeficient individuals. KSHV encodes 12 pre-microRNAs (pre-miRNAs), which are processed into 25 mature microRNAs (miRNAs). KSHV miRNAs maintain KSHV latency, enhance angiogenesis and dissemination of the infected cells, and interfere with the host immune system by regulating viral and cellular gene expression, ultimately contributing to KS development. In this review, we briefly introduce the biogenesis of miRNAs and then describe the recent advances in defining the roles and mechanisms of action of KSHV miRNAs in KS development...
March 2, 2017: Trends in Microbiology
https://www.readbyqxmd.com/read/28258628/intracorporeal-anastomoses-in-emergency-laparoscopic-colorectal-surgery-from-a-series-of-59-cases-where-and-how-to-do-it-a-technical-note
#18
Salomone Di Saverio, Arianna Birindelli, Matteo Mandrioli, Mauro Podda, Gian Andrea Binda
BACKGROUND: Laparoscopy offers the benefits of minimally invasive surgery and faster recovery. Acute surgical patients may potentially benefit from the greatest advantages of emergency laparoscopy, even more clinically relevant in acute rather than elective patients. Fashioning a laparoscopic intra-corporeal anastomosis (ICA) after emergent colorectal resection, whenever technically feasible and non-contraindicated for the patients' general and hemodynamic condition, represents the most challenging technical skill to be learned...
March 4, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28256321/trimetazidine-in-conditions-other-than-coronary-disease-old-drug-new-tricks
#19
REVIEW
Hai Zou, Xing-Xing Zhu, Ya-Hui Ding, Qin-Yang Jin, Lin-Yan Qian, Dong-Sheng Huang, Xue-Jiang Cen
Trimetazidine (TMZ) has traditionally been used as an anti-ischemic drug for coronary artery disease by selectively inhibiting the mitochondrial long-chain 3-ketoacyl-CoA thiolase. Recently, new applications for this therapy have been investigated. This article reviews alternative uses for TMZ in non-coronary artery diseases, such as non-ischemic cardiomyopathy, sepsis, myocardial dysfunction induced by anti-cancer drugs, diabetic cardiomyopathy and contrast-induced nephropathy.
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28248843/transarterial-embolization-for-hepatocellular-carcinoma-reasoning-on-mechanisms-of-action-tips-and-tricks-of-the-procedure
#20
Umberto G Rossi, Maurizio Cariati
No abstract text is available yet for this article.
April 2017: European Journal of Gastroenterology & Hepatology
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