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https://www.readbyqxmd.com/read/27918739/extra-tongue-oral-granular-cell-tumor-histological-and-immunohistochemical-aspect
#1
P-L Tobouti, F-M Pigatti, M-C Martins-Mussi, B-T Sedassari, S-C Orsini-Machado de Sousa
BACKGROUND: Granular cell tumor (GCT) is an uncommon benign tumor founded in any part of the body but mainly in the tongue. Extra-tongue oral granular cell tumor (ETOGCT) is rare with few cases reported. Here we describe seven cases of oral GCT located in sites other then the tongue and discuss histopathological and immunohistochemical differences between differential diagnoses Material and Methods: We retrieved all cases diagnosed with oral granular cell tumor, from the Oral Pathology Service at the School of Dentistry/ University of São Paulo, and excluded the ones sited in the tongue...
December 6, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27916178/arthroscopy-techniques-the-premier-arthroscopic-video-library
#2
EDITORIAL
J Martin Leland, James H Lubowitz, Matthew T Provencher
Arthroscopy has always been focused on its roots-providing practical, clinically relevant information for the practicing arthroscopist. In the digital age, there is a need for publication platforms dedicated to multimedia presentations, hence the birth of Arthroscopy Techniques, Arthroscopy's online video companion. With over 700 videos, our library is filled with an exceptional collection of arthroscopic educational material, with topics ranging from the basics of arthroscopy to the most complex surgical procedures...
December 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27914458/inactivation-of-inflammasomes-by-pathogens-regulates-inflammation
#3
REVIEW
F Yu Garib, A P Rizopulu, A A Kuchmiy, V F Garib
Inflammatory response is initiated and sustained by the action of quintessential pro-inflammatory cytokines of immune system namely IL-1β and IL-18. The maturation process of those cytokines is ensured by caspase-1 enzymatic activity, that is in turn is tightly controlled by multiprotein complexes called inflammasomes. Inflammasomes are activated in cells of innate immune system in response to recognition of conservative parts of microbes (pathogen-associated molecular patterns) or by sensing molecular signs of tissue damage (damage-associated molecular patterns)...
November 2016: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/27905466/weaponized-antibodies-use-new-tricks-to-fight-cancer
#4
Heidi Ledford
No abstract text is available yet for this article.
November 29, 2016: Nature
https://www.readbyqxmd.com/read/27898464/donor-derived-exosomes-the-trick-behind-the-semidirect-pathway-of-allorecognition
#5
Adrian E Morelli, William Bracamonte-Baran, William J Burlingham
PURPOSE OF REVIEW: The passenger leukocyte hypothesis predicts that after transplantation, donor antigen-presenting cells (APCs) from the graft present donor MHC molecules to directly alloreactive T cells in lymphoid organs. However, in certain transplantation models, recent evidence contradicts this long-standing concept. New findings demonstrate that host, instead of donor, APCs play a prominent role in allosensitization against donor MHC molecules via the semidirect pathway. A similar mechanism operates in development of T-cell split tolerance to noninherited maternal antigens...
November 24, 2016: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/27894469/the-association-of-perseverative-negative-thinking-with-depression-anxiety-and-emotional-distress-in-people-with-long-term-conditions-a-systematic-review
#6
Leanne Trick, Edward Watkins, Stacey Windeatt, Chris Dickens
OBJECTIVE: Depression is common in people with long term conditions, and is associated with worse medical outcomes. Previous research shows perseverative negative thinking (e.g. worry, rumination) predicts subsequent depression and worse medical outcomes, suggesting interventions targeting perseverative negative thinking could improve depression and medical outcomes. Previous studies recruited healthy individuals, however. This review aimed to determine the temporal relationship and strength of prospective association of perseverative negative thinking with depression, anxiety and emotional distress in people with long term conditions...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27889480/therapeutic-manipulation-of-ageing-repurposing-old-dogs-and-discovering-new-tricks
#7
REVIEW
Venkatesh Mallikarjun, Joe Swift
Ageing is a leading risk factor for many debilitating diseases. While age-related diseases have been the subject of over a century of intense investigation, until recently, physiological ageing was considered unavoidable. Pharmacological and genetic studies have since shown that ageing is a malleable process and that its abrogation can prevent its associated diseases. This review summarises a sample of the most promising efforts to deliver the products of ageing research to the clinic. Current efforts include the use of clinically approved drugs that have since been repurposed, as well as the development of novel therapeutics, to target ageing...
November 21, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27885984/a-new-trick-for-an-old-lipid
#8
Hayley Sharpe
Cholesterol can regulate the Hedgehog signalling pathway by directly binding to a receptor on the cell surface.
November 25, 2016: ELife
https://www.readbyqxmd.com/read/27866853/functional-annotation-of-ion-channel-structures-by-molecular-simulation
#9
Jemma L Trick, Sivapalan Chelvaniththilan, Gianni Klesse, Prafulla Aryal, E Jayne Wallace, Stephen J Tucker, Mark S P Sansom
Ion channels play key roles in cell membranes, and recent advances are yielding an increasing number of structures. However, their functional relevance is often unclear and better tools are required for their functional annotation. In sub-nanometer pores such as ion channels, hydrophobic gating has been shown to promote dewetting to produce a functionally closed (i.e., non-conductive) state. Using the serotonin receptor (5-HT3R) structure as an example, we demonstrate the use of molecular dynamics to aid the functional annotation of channel structures via simulation of the behavior of water within the pore...
December 6, 2016: Structure
https://www.readbyqxmd.com/read/27864754/tips-and-tricks-for-exogenous-application-of-synthetic-post-translationally-modified-peptides-to-plants
#10
Nathan Czyzewicz, Elisabeth Stes, Ive De Smet
The first signaling peptide discovered and purified was insulin in 1921. However, it was not until 1991 that the first peptide signal, systemin, was discovered in plants. Since the discovery of systemin, peptides have emerged as a potent and diverse class of signaling molecules in plant systems. Peptides consist of small amino acid sequences, which often act as ligands of receptor kinases. However, not all peptides are created equal, and signaling peptides are grouped into several subgroups dependent on the type of post-translational processing they undergo...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27852764/the-mechanics-of-head-supported-load-carriage-by-nepalese-porters
#11
G J Bastien, P A Willems, B Schepens, N C Heglund
In the Everest valley of Nepal, because of the rugged mountain terrain, roads are nothing more than dirt paths and all material must be conveyed on foot. The Nepalese porters routinely carry head-supported loads, which often exceed their body mass, over long distances up and down the steep mountain footpaths. In Africa, women transport their loads economically thanks to an energy-saving gait adaptation. We hypothesized that the Nepalese porters may have developed a corresponding mechanism. To investigate this proposition, we measured the mechanical work done during level walking in Nepalese porters while carrying different loads at several speeds...
November 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27852721/e-cigarettes-a-safer-alternative-for-teenagers-a-uk-focus-group-study-of-teenagers-views
#12
Shona Hilton, Heide Weishaar, Helen Sweeting, Filippo Trevisan, Srinivasa Vittal Katikireddi
OBJECTIVE: Concerns exist that e-cigarettes may be a gateway to traditional cigarettes and/or (re)normalise teenage smoking. This qualitative study explores how teenagers in the UK currently perceive e-cigarettes and how and why they do or do not use them. DESIGN: 16 focus groups were conducted across the UK between November 2014 and February 2015, with 83 teenagers aged 14-17. All discussions were digitally recorded, transcribed verbatim, imported into NVivo 10 and thematically analysed...
November 16, 2016: BMJ Open
https://www.readbyqxmd.com/read/27852209/editorial-old-drugs-learn-new-tricks-advances-and-applications-for-drug-repurposing
#13
EDITORIAL
Qi Liu
No abstract text is available yet for this article.
2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27846557/a-hat-trick-for-differentiation-therapy
#14
Paula A Kiberstis
No abstract text is available yet for this article.
October 21, 2016: Science
https://www.readbyqxmd.com/read/27837499/commercial-molecular-tests-for-fungal-diagnosis-from-a-practical-point-of-view
#15
Michaela Lackner, Cornelia Lass-Flörl
The increasing interest in molecular diagnostics is a result of tremendously improved knowledge on fungal infections in the past 20 years and the rapid development of new methods, in particular polymerase chain reaction. High expectations have been placed on molecular diagnostics, and the number of laboratories now using the relevant technology is rapidly increasing-resulting in an obvious need for standardization and definition of laboratory organization. In the past 10 years, multiple new molecular tools were marketed for the detection of DNA, antibodies, cell wall components, or other antigens...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27830985/teaching-an-old-dog-new-tricks-suppressing-activation-of-specific-mitogen-activated-kinases-as-a-potential-virulence-function-of-the-bacterial-avrrpt2-effector-protein
#16
Lennart Eschen-Lippold, Dierk Scheel, Justin Lee
AvrRpt2 is one of the first Pseudomonas syringae effector proteins demonstrated to be delivered into host cells. It suppresses plant immunity by modulating auxin signaling and cleavage of the membrane-localized defense regulator RIN4. We recently uncovered a novel potential virulence function of AvrRpt2, where it specifically blocked activation of mitogen-activated protein kinases, MPK4 and MPK11, but not of MPK3 and MPK6. Putative AvrRpt2 homologs from different phytopathogens and plant-associated bacteria showed distinct activities with respect to MPK4/11 activation suppression and RIN4 cleavage...
November 10, 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27821207/interrater-reliability-of-surveillance-for-ventilator-associated-events-and-pneumonia
#17
Meeta Prasad Kerlin, William E Trick, Deverick J Anderson, Hilary M Babcock, Ebbing Lautenbach, Renaud Gueret, Michael Klompas
OBJECTIVE To compare interrater reliabilities for ventilator-associated event (VAE) surveillance, traditional ventilator-associated pneumonia (VAP) surveillance, and clinical diagnosis of VAP by intensivists. DESIGN A retrospective study nested within a prospective multicenter quality improvement study. SETTING Intensive care units (ICUs) within 5 hospitals of the Centers for Disease Control and Prevention Epicenters. PATIENTS Patients who underwent mechanical ventilation. METHODS We selected 150 charts for review, including all VAEs and traditionally defined VAPs identified during the primary study and randomly selected charts of patients without VAEs or VAPs...
November 8, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27820666/trick-or-tween-an-inflammatory-surprise-when-m-tuberculosis-knocks-a-cell-s-door-and-no-tween-is-provided
#18
Ka-Wing Wong
No abstract text is available yet for this article.
November 7, 2016: Virulence
https://www.readbyqxmd.com/read/27819043/the-hijacking-of-a-receptor-kinase-driven-pathway-by-a-wheat-fungal-pathogen-leads-to-disease
#19
Gongjun Shi, Zengcui Zhang, Timothy L Friesen, Dina Raats, Tzion Fahima, Robert S Brueggeman, Shunwen Lu, Harold N Trick, Zhaohui Liu, Wun Chao, Zeev Frenkel, Steven S Xu, Jack B Rasmussen, Justin D Faris
Necrotrophic pathogens live and feed on dying tissue, but their interactions with plants are not well understood compared to biotrophic pathogens. The wheat Snn1 gene confers susceptibility to strains of the necrotrophic pathogen Parastagonospora nodorum that produce the SnTox1 protein. We report the positional cloning of Snn1, a member of the wall-associated kinase class of receptors, which are known to drive pathways for biotrophic pathogen resistance. Recognition of SnTox1 by Snn1 activates programmed cell death, which allows this necrotroph to gain nutrients and sporulate...
October 2016: Science Advances
https://www.readbyqxmd.com/read/27815976/deficient-median-nerve-prepulse-inhibition-of-the-blink-reflex-in-cervical-dystonia
#20
Oya Öztürk, Ayşegül Gündüz, Meral E Kızıltan
OBJECTIVE: We analyzed prepulse inhibition (PPI) of the blink reflex (BR) in patients with cervical dystonia (CD) to examine the sensory modulation of the motor system. METHODS: This study enrolled 22 consecutive patients with idiopathic CD and 25 age- and gender-matched healthy subjects. Prepulse inhibition of the BR was recorded after stimulating the median nerve at the wrist using an electrical stimulus twice at a perception threshold 100ms before a test stimulus to the supraorbital nerve...
December 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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