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https://www.readbyqxmd.com/read/29153883/conformational-dynamics-and-free-energy-of-bhrf1-binding-to-bim-bh3
#1
Mauro Lapelosa
The interaction between the Bim BH3 peptide and the viral protein BHRF1 is pivotal to understanding the fundamental molecular details of the mechanism used by the Epstein-Barr virus to trick the mammalian immune system. Here, we study the mechanism of binding/unbinding and compute the free energy for the association of the Bim peptide to the BHRF1 protein. Key elements of the binding mechanism are the conformational rearrangement together with a main free energy barrier of 11.5kcal/mol. The simulations show complete unbinding and rebinding of the Bim peptide to BHRF1...
November 10, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/29151118/semi-rigid-ureteroscopy-indications-tips-and-tricks
#2
REVIEW
Lily A Whitehurst, Bhaskar K Somani
Advances in ureteroscopic technology, alongside broadening treatment options have fuelled the rapid expansion of endourology. Semi-rigid ureteroscopy is a well-known procedure used globally for varying urological conditions, with high success rates. This article aims to provide 'tips and tricks' for the semi-rigid ureteroscopy procedure, and the management of commonly encountered pathology such as renal stones, ureteric strictures, and urothelial tumours.
November 18, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29148188/acutely-painful-scrotum-tips-traps-tricks-and-truths
#3
Craig A McBride, Bhaveshkumar Patel
No abstract text is available yet for this article.
November 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29146188/old-drug-new-tricks-chlorhexidine-acts-as-a-potential-allosteric-inhibitor-toward-pak1
#4
Han-Wei Huang, Xiang-Yu Zhang, Pei-Lu Song, Hai-Lun Jiang, Wei Li, Peng-Liang Wang, Jian Wang, Fu-Nan Liu
This paper describes the identification of chlorhexidine, an agent commonly used in clinical as a novel potential allosteric inhibitor of PAK1. In cellular assays, chlorhexidine showed a good inhibitory profile, and its inhibitory profile was even better than IPA-3, a well-known allosteric inhibitor. In pharmacology experiments, chlorhexidine successfully inhibited the relief of PAK1 dimer and inhibited the activation of PAK1. Our findings offer an insight for the new drug development of PAK1 inhibitor. We also provide a possible explanation for the phenomenon that the application of the chlorhexidine in peritoneal lavage inhibited the development of tumor...
November 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29143992/teaching-old-compounds-new-tricks-ddq-photocatalyzed-c-h-amination-of-arenes-with-carbamates-urea-and-n-heterocycles
#5
Somnath Das, Palani Natarajan, Burkhard König
The C-H amination of benzene derivatives was achieved using DDQ as photocatalyst and BocNH₂ as the amine source under aerobic conditions and visible light irradiation. Electron-deficient and electron-rich benzenes react as substrates with moderate to good product yields. The amine scope of the reaction comprises Boc-amine, carbamates, pyrazoles, sulfonimide and urea. Preliminary mechanistic investigations indicate a charge transfer complex between the amine and DDQ as essential intermediate of the reaction...
November 16, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29135966/monocular-visual-inertial-slam-continuous-preintegration-and-reliable-initialization
#6
Yi Liu, Zhong Chen, Wenjuan Zheng, Hao Wang, Jianguo Liu
In this paper, we propose a new visual-inertial Simultaneous Localization and Mapping (SLAM) algorithm. With the tightly coupled sensor fusion of a global shutter monocular camera and a low-cost Inertial Measurement Unit (IMU), this algorithm is able to achieve robust and real-time estimates of the sensor poses in unknown environment. To address the real-time visual-inertial fusion problem, we present a parallel framework with a novel IMU initialization method. Our algorithm also benefits from the novel IMU factor, the continuous preintegration method, the vision factor of directional error, the separability trick and the robust initialization criterion which can efficiently output reliable estimates in real-time on modern Central Processing Unit (CPU)...
November 14, 2017: Sensors
https://www.readbyqxmd.com/read/29133169/ureteroscopy-for-paediatric-calculi-the-twin-surgeon-model
#7
Bhaskar K Somani, Stephen Griffin
We describe our 'Tips and tricks' of ureteroscopy and lasertripsy (URSL) for paediatric ureteric calculi. All regional referrals directed to the paediatric urologist are discussed in a formal stone multidisciplinary team (MDT) meeting with urologists, radiologists, and biochemical pathologist. A paediatric urologist (SG) and an experienced adult endourologist (BS) do these stone procedures jointly as a twin-surgeon team approach for each patient.
November 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29130211/detection-of-the-first-round-of-translation-the-trick-assay
#8
Franka Voigt, Jan Eglinger, Jeffrey A Chao
Quantitative fluorescence microscopy techniques are frequently applied to answer fundamental biological questions. Single-molecule RNA imaging methods have enabled the direct observation of the initial steps of the mRNA life cycle in living cells, however, the dynamic mechanisms that regulate mRNA translation are still poorly understood. We have developed an RNA biosensor that can assess the translational state of individual mRNA transcripts with spatiotemporal resolution in living cells. In this chapter, we describe how to perform a TRICK (translating RNA imaging by coat protein knock-off) experiment and specifically focus on a detailed description of our image processing and data analysis procedure...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29126810/sensory-trick-splint-as-a-multimodal-therapy-for-oromandibular-dystonia
#9
Kazuya Yoshida
PURPOSE: Many patients with oromandibular dystonia, which is characterized by involuntary masticatory, lower facial, and/or tongue muscle contractions, experience relief of symptoms through sensory tricks such as eating chewing gum or candy. The aim of this study was to identify the factors influencing the effects of splints in patients with oromandibular dystonia. METHODS: Occlusal splints were inserted in 128 patients (89 women, 39 men) with oromandibular dystonia (102 with jaw closing dystonia, 20 with lingual dystonia, 5 with jaw deviation dystonia, 4 with jaw opening dystonia, 3 with lip dystonia, and 2 with jaw protrusion dystonia)...
November 7, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29123050/tricks-for-noncovalent-catalysis
#10
Anita E Mattson
No abstract text is available yet for this article.
November 10, 2017: Science
https://www.readbyqxmd.com/read/29120505/a-tutorial-in-small-molecule-identification-via-electrospray-ionization-mass-spectrometry-the-practical-art-of-structural-elucidation
#11
REVIEW
Thomas De Vijlder, Dirk Valkenborg, Filip Lemière, Edwin P Romijn, Kris Laukens, Filip Cuyckens
The identification of unknown molecules has been one of the cornerstone applications of mass spectrometry for decades. This tutorial reviews the basics of the interpretation of electrospray ionization-based MS and MS/MS spectra in order to identify small-molecule analytes (typically below 2000 Da). Most of what is discussed in this tutorial also applies to other atmospheric pressure ionization methods like atmospheric pressure chemical/photoionization. We focus primarily on the fundamental steps of MS-based structural elucidation of individual unknown compounds, rather than describing strategies for large-scale identification in complex samples...
November 9, 2017: Mass Spectrometry Reviews
https://www.readbyqxmd.com/read/29105872/dendritic-and-core-shell-corona-mesoporous-sister-nanospheres-from-polymer-surfactant-silica-self-entanglement
#12
Kun Zhang
Mesoporous nanospheres are highly regarded for their applications in nanomedicine, optical devices, batteries, nanofiltration and heterogeneous catalysis. In the latter field, the dendritic morphology favoring molecular diffusion is a very important morphology known for silica but not yet for carbon. A one-pot, easy and scalable co-sol-gel route using the triphasic resol-surfactant-silica system is shown to yield the topologies of the title by inner radial phase speciation control on a mass-transfer limited process depending on the relative polycondensation rates of the resol polymer and silica phases...
November 6, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29101556/laparoscopic-right-posterior-sectionectomy-lrps-surgical-techniques-and-clinical-outcomes
#13
Najaf N Siddiqi, Mahmoud Abuawwad, Mark Halls, Arab Rawashdeh, Francesco Giovinazzo, Anas Aljaiuossi, Dennis Wicherts, Mathieu D'Hondt, Mohammed Abu Hilal
BACKGROUND: Right posterior sectionectomy is one of the most technically challenging laparoscopic liver resections. Currently, there is limited published data regarding the technique and results required to better understand its safety and feasibility. AIM: To report our experience, results and techniques, highlighting a variety of tips and tricks to facilitate this resection. A video is attached for technical demonstration. METHODS: Retrospective review of prospectively maintained databases from June 2006 to June 2016...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29101212/teaching-an-old-pathway-new-tricks-targeting-btk-to-block-nlrp3
#14
Sarah E Henrickson
A proteomics screen identified BTK as a novel inflammasome regulator and demonstrated that blocking BTK can inhibit inflammasome activity.
November 3, 2017: Science Immunology
https://www.readbyqxmd.com/read/29100051/trick-or-treat-a-scary-good-new-approach-for-single-molecule-mrna-decay-analysis
#15
Joseph Russo, Jeffrey Wilusz
In this issue of Molecular Cell, Horvathova et al. (2017) have developed a powerful approach to single-molecule assessment of RNA decay in living cells by exploiting the ability of flavivirus RNA structural elements to trap XRN1 decay intermediates in dual-labeled reporter constructs.
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29098355/superior-glenoid-inclination-and-glenoid-bone-loss-definition-assessment-biomechanical-consequences-and-surgical-options
#16
REVIEW
L Favard, J Berhouet, G Walch, J Chaoui, C Lévigne
Correct anatomical alignment of the glenoid component is of central importance for wear and loosening in shoulder endoprostheses. The aim of this article is to review and clarify the biomechanical and clinical effects of incorrect glenoid inclination in reverse and anatomical joint replacements. Based on the literature and on our own work, statements are made about the following: (1) the glenoid inclination of a normal glenoid, a degenerative glenoid and a glenoid implant, and the consequences if superior inclination is too large, and (2) the surgical technique as well as tips and tricks for correct adjustment of the inclination...
November 2, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/29097345/tailoring-protocols-for-chest-ct-applications-when-and-how
#17
Roberto Iezzi, Anna Rita Larici, Paola Franchi, Riccardo Marano, Nicola Magarelli, Alessandro Posa, Biagio Merlino, Riccardo Manfredi, Cesare Colosimo
In the medical era of early detection of diseases and tailored therapies, an accurate characterization and staging of the disease is pivotal for treatment planning. The widespread use of computed tomography (CT)-often with the use of contrast material (CM)-probably represents the most important advance in diagnostic radiology. The result is a marked increase in radiation exposure of the population for medical purposes, with its intrinsic carcinogenic potential, and CM affecting kidney function. The radiologists should aim to minimize patient's risk by reducing radiation exposure and CM amount, while maintaining the highest image quality...
November 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29090656/trick-or-treat-microbial-pathogens-evolved-apoplastic-effectors-modulating-plant-susceptibility-to-infection
#18
Yan Wang, Yuanchao Wang
The apoplastic space between the plant cell wall and the plasma membrane constitutes a major battleground for plant-pathogen interactions. To survive in harsh conditions in the plant apoplast, pathogens must cope with various immune responses. During infection, plant pathogens secrete an arsenal of effector proteins into the apoplast milieu, some of which are detected by the plant surveillance system and, thus, activate plant innate immunity. Effectors that evade plant perception act in modulating plant apoplast immunity to favor successful pathogen infection...
November 1, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29089396/pathogenesis-of-dystonia-is-it-of-cerebellar-or-basal-ganglia-origin
#19
REVIEW
Ryuji Kaji, Kailash Bhatia, Ann M Graybiel
Dystonia is a disorder of motor programmes controlling semiautomatic movements or postures, with clinical features such as sensory trick, which suggests sensorimotor mismatch as the basis. Dystonia was originally classified as a basal ganglia disease. It is now regarded as a 'network' disorder including the cerebellum, but the exact pathogenesis being unknown. Rare autopsy studies have found pathology both in the striatum and the cerebellum, and functional disorganisation was reported in the somatosensory cortex in patients...
October 31, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29079484/robot-assisted-laparoscopic-megaureter-tapering-with-ureteral-reimplantation-tips-and-tricks
#20
Belinda Li, Bruce W Lindgren, Dennis B Liu, Edward M Gong
OBJECTIVE: The aim was to demonstrate surgical techniques used in pediatric robot-assisted laparoscopic megaureter tapering (RALMT) with ureteral reimplantation. We report on our preliminary experience. METHODS: We reviewed video of patients who underwent RALMT with ureteral reimplantation between August 2012 and November 2015. MT was performed extravesically and ureteral reimplantation was performed by extravesical detrusorrhaphy with ureteral anchoring. All patients had an intraoperatively placed ureteral stent...
October 12, 2017: Journal of Pediatric Urology
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