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https://www.readbyqxmd.com/read/28101939/care-planning-a-neoliberal-three-card-trick
#1
M McKeown, K Wright, D Mercer
No abstract text is available yet for this article.
January 18, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28095191/maximum-pseudolikelihood-estimation-for-model-based-clustering-of-time-series-data
#2
Hien D Nguyen, Geoffrey J McLachlan, Pierre Orban, Pierre Bellec, Andrew L Janke
Mixture of autoregressions (MoAR) models provide a model-based approach to the clustering of time series data. The maximum likelihood (ML) estimation of MoAR models requires evaluating products of large numbers of densities of normal random variables. In practical scenarios, these products converge to zero as the length of the time series increases, and thus the ML estimation of MoAR models becomes infeasible without the use of numerical tricks. We propose a maximum pseudolikelihood (MPL) estimation approach as an alternative to the use of numerical tricks...
January 17, 2017: Neural Computation
https://www.readbyqxmd.com/read/28093021/altering-ethanol-pharmacokinetics-to-treat-alcohol-use-disorder-can-you-teach-an-old-dog-new-tricks
#3
Carolina L Haass-Koffler, Fatemeh Akhlaghi, Robert M Swift, Lorenzo Leggio
Disulfiram was the first pharmacotherapy approved to treat alcohol use disorder in the 1950s. Disulfiram alters ethanol pharmacokinetics and causes uncomfortable reactions (e.g. headache, tachycardia, nausea, flushing and hypotension) when alcohol is consumed. Subsequently, a better understanding of the neurobiological pathways involved in alcohol use disorder led to the development of other medications (e.g. naltrexone and acamprosate). These neurobiological-based medications act on alcohol use disorder-related phenotypes including craving, stress, and/or withdrawal...
January 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28074089/antiviral-activity-of-animal-venom-peptides-and-related-compounds
#4
REVIEW
Élida Cleyse Gomes da Mata, Caroline Barbosa Farias Mourão, Marisa Rangel, Elisabeth Ferroni Schwartz
Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. Thus, new antiviral substances obtained from natural products have been prospected, including those derived from venomous animals...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28073329/the-other-side-of-magic
#5
Vebjørn Ekroll, Bilge Sayim, Johan Wagemans
When magicians perform spectacles that seem to defy the laws of nature, they do so by manipulating psychological reality. Hence, the principles underlying the art of conjuring are potentially of interest to psychological science. Here, we argue that perceptual and cognitive principles governing how humans experience hidden things and reason about them play a central role in many magic tricks. Different from tricks based on many other forms of misdirection, which require considerable skill on the part of the magician, many elements of these tricks are essentially self-working because they rely on automatic perceptual and cognitive processes...
January 2017: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
https://www.readbyqxmd.com/read/28070622/haptic-feedback-attenuates-illusory-bias-in-pantomime-grasping-evidence-for-a-visuo-haptic-calibration
#6
Jillian Chan, Matthew Heath
Relative visual information has been shown to mediate grasping responses directed to an area previously occupied by a target object (i.e., pantomime-grasping) and is an information type functionally distinct from the absolute visual information supporting naturalistic grasping (i.e., grasping a physical target). Pantomime- and naturalistic grasps differ not only in terms of their visual properties, but also because the former lacks physical interaction with a target object (i.e., no-haptic feedback). The absence of haptic feedback may represent a reason why pantomime- and naturalistic grasps differ...
January 9, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28065912/the-use-of-contrast-echo-to-detect-shunts-at-atrial-level-in-a-mustard-or-senning-repair-for-transposition-of-the-great-arteries-you-can-teach-an-old-dog-new-tricks
#7
EDITORIAL
Folkert Meijboom, Berto Bouma
No abstract text is available yet for this article.
January 8, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28057206/tricks-and-treats-welcome-to-our-public-health-world-in-2017
#8
EDITORIAL
F Sim, P Mackie
No abstract text is available yet for this article.
January 2017: Public Health
https://www.readbyqxmd.com/read/28057163/ceftazidime-avibactam-who-says-you-can-t-teach-an-old-drug-new-tricks
#9
Katie E Barber, Jessica K Ortwine, Ronda L Akins
PURPOSE: Gram-negative resistance continues to rise with treatment options becoming more limited. Ceftazidime/avibactam was recently approved in the United States and Europe, which combines an established third-generation cephalosporin with a new, unique, non-β-lactam β-lactamase inhibitor. This review conducts a thorough examination of structure, pharmacology, spectrum of activity, pharmacokinetics/pharmacodynamics, in vitro and clinical efficacy and safety/tolerability of ceftazidime/avibactam, as well as detailed future directions for the agent...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28054957/molecular-biomarkers-for-prediction-of-targeted-therapy-response-in-metastatic-breast-cancer-trick-or-treat
#10
REVIEW
Angela Toss, Marta Venturelli, Chiara Peterle, Federico Piacentini, Stefano Cascinu, Laura Cortesi
In recent years, the study of genomic alterations and protein expression involved in the pathways of breast cancer carcinogenesis has provided an increasing number of targets for drugs development in the setting of metastatic breast cancer (i.e., trastuzumab, everolimus, palbociclib, etc.) significantly improving the prognosis of this disease. These drugs target specific molecular abnormalities that confer a survival advantage to cancer cells. On these bases, emerging evidence from clinical trials provided increasing proof that the genetic landscape of any tumor may dictate its sensitivity or resistance profile to specific agents and some studies have already showed that tumors treated with therapies matched with their molecular alterations obtain higher objective response rates and longer survival...
January 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28048358/th-f-201-01-the-problem-is-this-a-trick-question
#11
C Bloch
: Multiple choice questions are a tool medical physicists encounter throughout their careers. They are a commonly used method of assessment during our early didactic training (graduate school, residency and board certification). They are used throughout our MOC process both in SAMs and online CE. And they are used for the MOC exam every 10 years. While we have significant training in answering these multiple choice questions, we rarely receive training in how to construct effective multiple choice questions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045121/interactome-of-e-piscicida-and-grouper-liver-proteins-reveals-strategies-of-bacterial-infection-and-host-immune-response
#12
Hui Li, Qing-Feng Zhu, Xuan-Xian Peng, Bo Peng
The occurrence of infectious diseases is related to heterogeneous protein interactions between a host and a microbe. Therefore, elucidating the host-pathogen interplay is essential. We previously revealed the protein interactome between Edwardsiella piscicida and fish gill cells, and the present study identified the protein interactome between E. piscicida and E. drummondhayi liver cells. E. drummondhayi liver cells and bacterial pull-down approaches were used to identify E. piscicida outer membrane proteins that bind to liver cells and fish liver cell proteins that interact with bacterial cells, respectively...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28031061/which-comorbid-conditions-should-we-be-analyzing-as-risk-factors-for-healthcare-associated-infections
#13
Anthony D Harris, Lisa Pineles, Deverick Anderson, Keith F Woeltje, William E Trick, Keith S Kaye, Deborah S Yokoe, Ann-Christine Nyquist, David P Calfee, Surbhi Leekha
OBJECTIVE To determine which comorbid conditions are considered causally related to central-line associated bloodstream infection (CLABSI) and surgical-site infection (SSI) based on expert consensus. DESIGN Using the Delphi method, we administered an iterative, 2-round survey to 9 infectious disease and infection control experts from the United States. METHODS Based on our selection of components from the Charlson and Elixhauser comorbidity indices, 35 different comorbid conditions were rated from 1 (not at all related) to 5 (strongly related) by each expert separately for CLABSI and SSI, based on perceived relatedness to the outcome...
December 29, 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28013503/applying-fluorescence-correlation-spectroscopy-to-investigate-peptide-induced-membrane-disruption
#14
Kasper Kristensen, Jonas R Henriksen, Thomas L Andresen
There is considerable interest in understanding the interactions of antimicrobial peptides with phospholipid membranes. Fluorescence correlation spectroscopy (FCS) is a powerful experimental technique that can be used to gain insight into these interactions. Specifically, FCS can be used to quantify leakage of fluorescent molecules of different sizes from large unilamellar lipid vesicles, thereby providing a tool for estimating the size of peptide-induced membrane disruptions. If fluorescently labeled lipids are incorporated into the membranes of the vesicles, FCS can also be used to obtain information about whether leakage occurs due to localized membrane perturbations or global membrane destabilization...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28013339/genetics-of-obesity-can-an-old-dog-teach-us-new-tricks
#15
REVIEW
Giles S H Yeo
At one level, obesity is clearly a problem of simple physics, a result of eating too much and not expending enough energy. The more complex question, however, is why do some people eat more than others? Studies of human and mouse genetics over the past two decades have uncovered a number of pathways within the brain that play a key role in the control of food intake. A prime example is the leptin-melanocortin pathway, which we now know greatly contributes to mammalian appetitive behaviour. However, genetic disruption of this pathway remains rare and does not represent the major burden of the disease that is carried by those of us with 'common obesity'...
December 24, 2016: Diabetologia
https://www.readbyqxmd.com/read/28009841/use-of-cellular-decapping-activators-by-positive-strand-rna-viruses
#16
REVIEW
Jennifer Jungfleisch, Bernat Blasco-Moreno, Juana Díez
Positive-strand RNA viruses have evolved multiple strategies to not only circumvent the hostile decay machinery but to trick it into being a priceless collaborator supporting viral RNA translation and replication. In this review, we describe the versatile interaction of positive-strand RNA viruses and the 5'-3' mRNA decay machinery with a focus on the viral subversion of decapping activators. This highly conserved viral trickery is exemplified with the plant Brome mosaic virus, the animal Flock house virus and the human hepatitis C virus...
December 21, 2016: Viruses
https://www.readbyqxmd.com/read/28004898/tips-and-tricks-in-vascular-access-for-t-evar
#17
Beatrice Fiorucci, Nikolaos Tsilimparis, Fiona Rohlffs, Franziska Heidemann, Sebastian E Debus, Tilo Kölbel
Endovascular repair has become the treatment of choice for thoracic and abdominal aortic pathologies in the last decades, and is associated with excellent results in terms of perioperative, mid- and long-term morbidity and mortality. Access vessels play a central role in these procedures since access-related issues can increase the rates of technical failures and determine clinical complications for the patient. Therefore, accurate preoperative clinical evaluation and review of the preoperative images are mandatory...
December 22, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27995208/a-systematic-and-technical-guide-on-how-to-reduce-a-shoulder-dislocation
#18
REVIEW
H Alkaduhimi, J A van der Linde, M Flipsen, D F P van Deurzen, M P J van den Bekerom
OBJECTIVES: Our objective is to provide a systematic and technical guide on how to reduce a shoulder dislocation, based on techniques that have been described in literature for patients with anterior and posterior shoulder instability. MATERIALS AND METHODS: A PubMed and EMBASE query was performed, screening all relevant literature on the closed reduction techniques. Studies regarding open reduction techniques and studies with fracture dislocations were excluded...
December 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27994060/twisting-a-%C3%AE-carotene-an-adaptive-trick-from-nature-for-dissipating-energy-during-photoprotection
#19
Manuel J Llansola-Portoles, Roman Sobotka, Elizabeth Kish, Mahendra Kumar Shukla, Andrew A Pascal, Tomáš Polívka, Bruno Robert
Cyanobacteria possess a family of one-helix high-light-inducible proteins (Hlips) that are homologous to light-harvesting antenna of plants and algae. An Hlip protein, high light inducible protein D (HliD) purified as a small complex with the Ycf39 protein is evaluated using resonance Raman spectroscopy. We show that the HliD binds two different β-carotenes, each present in two non-equivalent binding pockets with different conformations, having their (0,0) absorption maxima at 489 and 522 nm respectively. Both populations of β-carotene molecules were in all-trans configuration and the absorption position of the farthest blue-shifted β-carotene was attributed entirely to the polarizability of the environment in its binding pocked...
December 19, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27989601/epileptic-spasms-175-years-on-trying-to-teach-an-old-dog-new-tricks
#20
Jo M Wilmshurst, Roland C Ibekwe, Finbar J K O'Callaghan
PURPOSE: This text provides an overview of how the condition "infantile spasms" has evolved in the last 175 years. METHOD: Key references are summarised to assimilate this review. RESULTS: Infantile spasms, first described by Dr West in 1841, has undergone extensive investigation to understand the pathogenesis, aetiologies, optimal intervention and most likely prognosis for the affected child. The terminology has recently evolved such that the preferred term for the condition is now "epileptic spasms" in recognition of the fact that cases can present outside infancy...
December 6, 2016: Seizure: the Journal of the British Epilepsy Association
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