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https://www.readbyqxmd.com/read/27765852/targeting-binding-function-3-of-the-androgen-receptor-blocks-its-co-chaperone-interactions-nuclear-translocation-and-activation
#1
Nada Lallous, Eric Leblanc, Ravi S N Munuganti, Mohamed D H Hassona, Nader Al Nakouzi, Shannon Awrey, Helene Morin, Mani Roshan-Moniri, Kriti Singh, Sam Lawn, Takeshi Yamazaki, Hans H Adomat, Christophe Andre, Mads Daugaard, Robert N Young, Emma S Tomlinson Guns, Paul S Rennie, Artem Cherkasov
The development of new antiandrogens, such as enzalutamide, or androgen synthesis inhibitors like abiraterone has improved patient outcomes in the treatment of advanced prostate cancer. However, due to the development of drug resistance and tumor cell survival, a majority of these patients progress to the refractory state of castration-resistant prostate cancer (CRPC). Thus, newer therapeutic agents and a better understanding of their mode of action are needed for treating these CRPC patients. We demonstrated previously that targeting the Binding Function 3 (BF3) pocket of the androgen receptor (AR) has great potential for treating patients with CRPC...
December 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27494729/an-anterior-left-ventricular-lead-position-is-associated-with-increased-mortality-and-non-response-in-cardiac-resynchronization-therapy
#2
Mads Brix Kronborg, Jens Brock Johansen, Sam Riahi, Helen Hoegh Petersen, Jens Haarbo, Ole Dan Jørgensen, Jens Cosedis Nielsen
BACKGROUND: Non-response to cardiac resynchronization therapy (CRT) might be due to insufficient resynchronization as a result of a sub-optimal left ventricular lead positon (LV-LP). OBJECTIVE: To evaluate the impact of different LV-LPs on mortality and symptomatic improvement in a large cohort of patients treated with CRT. METHODS: We performed a nationwide cohort study on consecutive patients receiving a CRT device from 1997 to 2012 registered in the Danish pacemaker and ICD register...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27134142/multi-layered-regulation-of-spl15-and-cooperation-with-soc1-integrate-endogenous-flowering-pathways-at-the-arabidopsis-shoot-meristem
#3
Youbong Hyun, René Richter, Coral Vincent, Rafael Martinez-Gallegos, Aimone Porri, George Coupland
Flowering is initiated in response to environmental and internal cues that are integrated at the shoot apical meristem (SAM). We show that SPL15 coordinates the basal floral promotion pathways required for flowering of Arabidopsis in non-inductive environments. SPL15 directly activates transcription of the floral regulators FUL and miR172b in the SAM during floral induction, whereas its paralog SPL9 is expressed later on the flanks of the SAM. The capacity of SPL15 to promote flowering is regulated by age through miR156, which targets SPL15 mRNA, and gibberellin (GA), which releases SPL15 from DELLAs...
May 9, 2016: Developmental Cell
https://www.readbyqxmd.com/read/26807727/innovation-of-a-regulatory-mechanism-modulating-semi-determinate-stem-growth-through-artificial-selection-in-soybean
#4
Yunfeng Liu, Dajian Zhang, Jieqing Ping, Shuai Li, Zhixiang Chen, Jianxin Ma
It has been demonstrated that Terminal Flowering 1 (TFL1) in Arabidopsis and its functional orthologs in other plants specify indeterminate stem growth through their specific expression that represses floral identity genes in shoot apical meristems (SAMs), and that the loss-of-function mutations at these functional counterparts result in the transition of SAMs from the vegetative to reproductive state that is essential for initiation of terminal flowering and thus formation of determinate stems. However, little is known regarding how semi-determinate stems, which produce terminal racemes similar to those observed in determinate plants, are specified in any flowering plants...
January 2016: PLoS Genetics
https://www.readbyqxmd.com/read/25636918/xaantal2-agl14-is-an-important-component-of-the-complex-gene-regulatory-network-that-underlies-arabidopsis-shoot-apical-meristem-transitions
#5
Rigoberto V Pérez-Ruiz, Berenice García-Ponce, Nayelli Marsch-Martínez, Yamel Ugartechea-Chirino, Mitzi Villajuana-Bonequi, Stefan de Folter, Eugenio Azpeitia, José Dávila-Velderrain, David Cruz-Sánchez, Adriana Garay-Arroyo, María de la Paz Sánchez, Juan M Estévez-Palmas, Elena R Álvarez-Buylla
In Arabidopsis thaliana, multiple genes involved in shoot apical meristem (SAM) transitions have been characterized, but the mechanisms required for the dynamic attainment of vegetative, inflorescence, and floral meristem (VM, IM, FM) cell fates during SAM transitions are not well understood. Here we show that a MADS-box gene, XAANTAL2 (XAL2/AGL14), is necessary and sufficient to induce flowering, and its regulation is important in FM maintenance and determinacy. xal2 mutants are late flowering, particularly under short-day (SD) condition, while XAL2 overexpressing plants are early flowering, but their flowers have vegetative traits...
May 2015: Molecular Plant
https://www.readbyqxmd.com/read/25475561/in-vitro-flowering-associated-protein-changes-in-dendrocalamus-hamiltonii
#6
Devinder Kaur, Vivek Dogra, Pooja Thapa, Amita Bhattacharya, Anil Sood, Yelam Sreenivasulu
In Dendrocalamus hamiltonii, conversion of vegetative meristem to a floral meristem was successfully achieved on flower induction medium. A total of 128 differentially expressed proteins were evidenced by 2DE in floral meristem protein profiles. Analysis of 103 proteins through PMF revealed change in abundance in the content of 79 proteins, disappearance and new appearance in the content of 7 and 17 proteins, respectively. MS/MS and subsequent homology search identified 65 proteins that were involved in metabolism (22 proteins), regulatory (11 proteins), signaling and transportation (12 proteins), stress (6 proteins), flowering (8 proteins), and unknown functions (6 proteins)...
April 2015: Proteomics
https://www.readbyqxmd.com/read/25174034/etiologic-heterogeneity-among-non-hodgkin-lymphoma-subtypes-the-interlymph-non-hodgkin-lymphoma-subtypes-project
#7
Lindsay M Morton, Susan L Slager, James R Cerhan, Sophia S Wang, Claire M Vajdic, Christine F Skibola, Paige M Bracci, Silvia de Sanjosé, Karin E Smedby, Brian C H Chiu, Yawei Zhang, Sam M Mbulaiteye, Alain Monnereau, Jennifer J Turner, Jacqueline Clavel, Hans-Olov Adami, Ellen T Chang, Bengt Glimelius, Henrik Hjalgrim, Mads Melbye, Paolo Crosignani, Simonetta di Lollo, Lucia Miligi, Oriana Nanni, Valerio Ramazzotti, Stefania Rodella, Adele Seniori Costantini, Emanuele Stagnaro, Rosario Tumino, Carla Vindigni, Paolo Vineis, Nikolaus Becker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Pierluigi Cocco, Lenka Foretova, Marc Maynadié, Alexandra Nieters, Anthony Staines, Joanne S Colt, Wendy Cozen, Scott Davis, Anneclaire J de Roos, Patricia Hartge, Nathaniel Rothman, Richard K Severson, Elizabeth A Holly, Timothy G Call, Andrew L Feldman, Thomas M Habermann, Mark Liebow, Aaron Blair, Kenneth P Cantor, Eleanor V Kane, Tracy Lightfoot, Eve Roman, Alex Smith, Angela Brooks-Wilson, Joseph M Connors, Randy D Gascoyne, John J Spinelli, Bruce K Armstrong, Anne Kricker, Theodore R Holford, Qing Lan, Tongzhang Zheng, Laurent Orsi, Luigino Dal Maso, Silvia Franceschi, Carlo La Vecchia, Eva Negri, Diego Serraino, Leslie Bernstein, Alexandra Levine, Jonathan W Friedberg, Jennifer L Kelly, Sonja I Berndt, Brenda M Birmann, Christina A Clarke, Christopher R Flowers, James M Foran, Marshall E Kadin, Ora Paltiel, Dennis D Weisenburger, Martha S Linet, Joshua N Sampson
BACKGROUND: Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous subtypes. Previously, study size has limited the ability to compare and contrast the risk factor profiles among these heterogeneous subtypes. METHODS: We pooled individual-level data from 17 471 NHL cases and 23 096 controls in 20 case-control studies from the International Lymphoma Epidemiology Consortium (InterLymph). We estimated the associations, measured as odds ratios, between each of 11 NHL subtypes and self-reported medical history, family history of hematologic malignancy, lifestyle factors, and occupation...
August 2014: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/25174022/rationale-and-design-of-the-international-lymphoma-epidemiology-consortium-interlymph-non-hodgkin-lymphoma-subtypes-project
#8
Lindsay M Morton, Joshua N Sampson, James R Cerhan, Jennifer J Turner, Claire M Vajdic, Sophia S Wang, Karin E Smedby, Silvia de Sanjosé, Alain Monnereau, Yolanda Benavente, Paige M Bracci, Brian C H Chiu, Christine F Skibola, Yawei Zhang, Sam M Mbulaiteye, Michael Spriggs, Dennis Robinson, Aaron D Norman, Eleanor V Kane, John J Spinelli, Jennifer L Kelly, Carlo La Vecchia, Luigino Dal Maso, Marc Maynadié, Marshall E Kadin, Pierluigi Cocco, Adele Seniori Costantini, Christina A Clarke, Eve Roman, Lucia Miligi, Joanne S Colt, Sonja I Berndt, Andrea Mannetje, Anneclaire J de Roos, Anne Kricker, Alexandra Nieters, Silvia Franceschi, Mads Melbye, Paolo Boffetta, Jacqueline Clavel, Martha S Linet, Dennis D Weisenburger, Susan L Slager
BACKGROUND: Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project, an international collaborative effort to investigate the etiologies of NHL subtypes...
August 2014: Journal of the National Cancer Institute. Monographs
https://www.readbyqxmd.com/read/25005919/dt2-is-a-gain-of-function-mads-domain-factor-gene-that-specifies-semideterminacy-in-soybean
#9
Jieqing Ping, Yunfeng Liu, Lianjun Sun, Meixia Zhao, Yinghui Li, Maoyun She, Yi Sui, Feng Lin, Xiaodong Liu, Zongxiang Tang, Hanh Nguyen, Zhixi Tian, Lijuan Qiu, Randall L Nelson, Thomas E Clemente, James E Specht, Jianxin Ma
Similar to Arabidopsis thaliana, the wild soybeans (Glycine soja) and many cultivars exhibit indeterminate stem growth specified by the shoot identity gene Dt1, the functional counterpart of Arabidopsis TERMINAL FLOWER1 (TFL1). Mutations in TFL1 and Dt1 both result in the shoot apical meristem (SAM) switching from vegetative to reproductive state to initiate terminal flowering and thus produce determinate stems. A second soybean gene (Dt2) regulating stem growth was identified, which, in the presence of Dt1, produces semideterminate plants with terminal racemes similar to those observed in determinate plants...
July 2014: Plant Cell
https://www.readbyqxmd.com/read/24699640/structure-and-possible-mechanism-of-the-ccbj-methyltransferase-from-streptomyces-caelestis
#10
Jacob Bauer, Gabriela Ondrovičová, Lucie Najmanová, Vladimír Pevala, Zdeněk Kameník, Július Koštan, Jiří Janata, Eva Kutejová
The S-adenosyl-L-methionine (SAM)-dependent methyltransferase CcbJ from Streptomyces caelestis catalyzes one of the final steps in the biosynthesis of the antibiotic celesticetin, methylation of the N atom of its proline moiety, which greatly enhances the activity of the antibiotic. Since several celesticetin variants exist, this enzyme may be able to act on a variety of substrates. The structures of CcbJ determined by MAD phasing at 3.0 Å resolution, its native form at 2.7 Å resolution and its complex with S-adenosyl-L-homocysteine (SAH) at 2...
April 2014: Acta Crystallographica. Section D, Biological Crystallography
https://www.readbyqxmd.com/read/24557614/alleviation-of-cell-damage-in-experimental-anp-in-rats-by-administration-of-chondroitin-sulfate-reduces
#11
Zhongye He, Renxuan Guo, Chengyao Xie, Nan Liu, Yang Li, Wen Song
In order to explore the effects of retrograde infusion of chondroitin-sulfate via the pancreatic duct on cytoprotection and attenuation of oxidative damage during acute necrotic pancreatitis (ANP), male Wistar rats were randomly divided into three groups: A, B (experimental groups) and C (sham operation, control group). The rats in group A was subjected to retrograde injection of 5% sodium taurocholate via the pancreatic duct, and those in group B received chondroitin-sulfate therapy after ANP induction. All rats in three groups were killed at 6 h...
February 2007: Frontiers of Medicine in China
https://www.readbyqxmd.com/read/24183309/assessment-of-interferon-related-biomarkers-in-aicardi-gouti%C3%A3-res-syndrome-associated-with-mutations-in-trex1-rnaseh2a-rnaseh2b-rnaseh2c-samhd1-and-adar-a-case-control-study
#12
Gillian I Rice, Gabriella M A Forte, Marcin Szynkiewicz, Diana S Chase, Alec Aeby, Mohamed S Abdel-Hamid, Sam Ackroyd, Rebecca Allcock, Kathryn M Bailey, Umberto Balottin, Christine Barnerias, Genevieve Bernard, Christine Bodemer, Maria P Botella, Cristina Cereda, Kate E Chandler, Lyvia Dabydeen, Russell C Dale, Corinne De Laet, Christian G E L De Goede, Mireia Del Toro, Laila Effat, Noemi Nunez Enamorado, Elisa Fazzi, Blanca Gener, Madli Haldre, Jean-Pierre S-M Lin, John H Livingston, Charles Marques Lourenco, Wilson Marques, Patrick Oades, Pärt Peterson, Magnhild Rasmussen, Agathe Roubertie, Johanna Loewenstein Schmidt, Stavit A Shalev, Rogelio Simon, Ronen Spiegel, Kathryn J Swoboda, Samia A Temtamy, Grace Vassallo, Catheline N Vilain, Julie Vogt, Vanessa Wermenbol, William P Whitehouse, Doriette Soler, Ivana Olivieri, Simona Orcesi, Mona S Aglan, Maha S Zaki, Ghada M H Abdel-Salam, Adeline Vanderver, Kai Kisand, Flore Rozenberg, Pierre Lebon, Yanick J Crow
BACKGROUND: Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR). The disease is severe and effective treatments are urgently needed. We investigated the status of interferon-related biomarkers in patients with AGS with a view to future use in diagnosis and clinical trials. METHODS: In this case-control study, samples were collected prospectively from patients with mutation-proven AGS...
December 2013: Lancet Neurology
https://www.readbyqxmd.com/read/23346157/translation-and-validation-of-the-korean-version-of-the-39-item-parkinson-s-disease-questionnaire
#13
Do-Young Kwon, Jae Woo Kim, Hyeo-Il Ma, Tae-Beom Ahn, Jinwhan Cho, Phil Hyu Lee, Sun Ju Chung, Joong-Seok Kim, Jong Sam Baik, Seong-Beom Koh
BACKGROUND AND PURPOSE: The importance of health-related quality of life (HrQoL) has been increasingly emphasized when assessing and providing treatment to patients with chronic, progressive, degenerative disorders. The 39-item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient-reporting scale to assess HrQoL in Parkinson's disease (PD). This study evaluated the validity and reliability of the translated Korean version of the PDQ-39 (K-PDQ-39). METHODS: One hundred and two participants with PD from 10 movement disorder clinics at university-affiliated hospitals in South Korea completed the K-PDQ-39...
January 2013: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/23323136/validation-of-the-korean-version-of-the-nonmotor-symptoms-scale-for-parkinson-s-disease
#14
Seong-Beom Koh, Jae Woo Kim, Hyeo-Il Ma, Tae-Beom Ahn, Jin Whan Cho, Phil Hyu Lee, Sun Ju Chung, Joong-Seok Kim, Do Young Kwon, Jong Sam Baik
BACKGROUND AND PURPOSE: Non-motor symptoms are common in Parkinson's disease (PD), and are the primary cause of disability in many PD patients. Our aim in this study was to translate the origin non-motor symptoms scale for PD (NMSS), which was written in English, into Korean (K-NMSS), and to evaluate its reliability and validity for use with Korean-speaking patients with PD. METHODS: In total, 102 patients with PD from 9 movement disorders sections of university teaching hospitals in Korea were enrolled in this study...
December 2012: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/23230849/oslec1-oshap3e-participates-in-the-determination-of-meristem-identity-in-both-vegetative-and-reproductive-developments-of-rice
#15
Jing-Jing Zhang, Hong-Wei Xue
In the vegetative phase of plant development, the shoot apical meristem (SAM) produces leaf primordia in regular phyllotaxy, and transforms to the inflorescence meristem when the plant enters reproductive growth, which will undergo a series of identity differentiations and will finally form a complete and fertile panicle. Our previous studies indicated a tissue-specific expression pattern of the OsLEC1 (leafy cotyledon) gene, which is homologous to the Arabidopsis AtLEC1 gene and belongs to the CCAAT-binding protein HAP3 subfamily, during embryo development...
March 2013: Journal of Integrative Plant Biology
https://www.readbyqxmd.com/read/22902690/agl24-acts-in-concert-with-soc1-and-ful-during-arabidopsis-floral-transition
#16
Stefano Torti, Fabio Fornara
Arabidopsis plants flower in response to long days (LDs). Exposure of leaves to inductive day lengths activates expression of FLOWERING LOCUS T (FT) protein which moves to the shoot apical meristem (SAM) to induce developmental reprogramming. SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1) and FRUITFULL (FUL) are induced by FT at the apex. We previously screened the SAM for mRNAs of genes required to promote the floral transition in response to photoperiod, and conducted detailed expression and functional analyses on several putative candidates...
October 1, 2012: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/22586867/parent-perspectives-of-clinical-psychology-access-when-experiencing-distress
#17
Sam Cooke, Ian Smith, Emma Turl, Emma Arnold, Rachel M Msetfi
Around 20 to 30% of parents experience mental health difficulties within their child's first year, but only a small proportion go on to access specialist services. This is despite growing evidence around the positive benefits of psychosocial interventions for both parents and children. Previous research highlights facilitators and barriers to generic healthcare services for mothers with postnatal depression. The current study adopted a qualitative methodology to explore parents' own perceptions of the barriers and facilitators to clinical psychology specifically...
April 2012: Community Practitioner: the Journal of the Community Practitioners' & Health Visitors' Association
https://www.readbyqxmd.com/read/22570445/inflorescence-meristem-identity-in-rice-is-specified-by-overlapping-functions-of-three-ap1-ful-like-mads-box-genes-and-pap2-a-sepallata-mads-box-gene
#18
Kaoru Kobayashi, Naoko Yasuno, Yutaka Sato, Masahiro Yoda, Ryo Yamazaki, Mayumi Kimizu, Hitoshi Yoshida, Yoshiaki Nagamura, Junko Kyozuka
In plants, the transition to reproductive growth is of particular importance for successful seed production. Transformation of the shoot apical meristem (SAM) to the inflorescence meristem (IM) is the crucial first step in this transition. Using laser microdissection and microarrays, we found that expression of PANICLE PHYTOMER2 (PAP2) and three APETALA1 (AP1)/FRUITFULL (FUL)-like genes (MADS14, MADS15, and MADS18) is induced in the SAM during meristem phase transition in rice (Oryza sativa). PAP2 is a MADS box gene belonging to a grass-specific subclade of the SEPALLATA subfamily...
May 2012: Plant Cell
https://www.readbyqxmd.com/read/21624980/overexpression-of-eve1-a-novel-ubiquitin-family-protein-arrests-inflorescence-stem-development-in-arabidopsis
#19
Hyun-Ju Hwang, Hoyeun Kim, Young-Min Jeong, Monica Y Choi, So-Young Lee, Sang-Gu Kim
In Arabidopsis, inflorescence stem formation is a critical process in phase transition from the vegetative to the reproductive state. Although inflorescence stem development has been reported to depend on the expression of a variety of genes during floral induction and repression, little is known about the molecular mechanisms involved in the control of inflorescence stem formation. By activation T-DNA tagging mutagenesis of Arabidopsis, a dominant gain-of-function mutation, eve1-D (eternally vegetative phase1-Dominant), which has lost the ability to form an inflorescence stem, was isolated...
August 2011: Journal of Experimental Botany
https://www.readbyqxmd.com/read/21533074/gwas-of-follicular-lymphoma-reveals-allelic-heterogeneity-at-6p21-32-and-suggests-shared-genetic-susceptibility-with-diffuse-large-b-cell-lymphoma
#20
Karin E Smedby, Jia Nee Foo, Christine F Skibola, Hatef Darabi, Lucia Conde, Henrik Hjalgrim, Vikrant Kumar, Ellen T Chang, Nathaniel Rothman, James R Cerhan, Angela R Brooks-Wilson, Emil Rehnberg, Ishak D Irwan, Lars P Ryder, Peter N Brown, Paige M Bracci, Luz Agana, Jacques Riby, Wendy Cozen, Scott Davis, Patricia Hartge, Lindsay M Morton, Richard K Severson, Sophia S Wang, Susan L Slager, Zachary S Fredericksen, Anne J Novak, Neil E Kay, Thomas M Habermann, Bruce Armstrong, Anne Kricker, Sam Milliken, Mark P Purdue, Claire M Vajdic, Peter Boyle, Qing Lan, Shelia H Zahm, Yawei Zhang, Tongzhang Zheng, Stephen Leach, John J Spinelli, Martyn T Smith, Stephen J Chanock, Leonid Padyukov, Lars Alfredsson, Lars Klareskog, Bengt Glimelius, Mads Melbye, Edison T Liu, Hans-Olov Adami, Keith Humphreys, Jianjun Liu
Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21...
April 2011: PLoS Genetics
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