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Young Hee Sung, Hee Jin Kim, Seong Beom Koh, Joong Seok Kim, Sang Jin Kim, Sang Myung Cheon, Jin Whan Cho, Yoon Joong Kim, Hyeo Il Ma, Mee Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong Min Kim, In Uk Song, Han Joon Kim, Ji Young Kim, Do Young Kwon, Jae Hyeok Lee, Jee Young Lee, Ji Seon Kim, Ji Young Yun, Jin Yong Hong, Mi Jung Kim, Jinyoung Youn, Ji Sun Kim, Eung Seok Oh, Hui Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum Yil Kwon, Hyung Eun Park, Su Yun Lee, Younsoo Kim, Hee Tae Kim, Tae Beom Ahn
BACKGROUND: Sleep problems commonly occur in patients with Parkinson's disease (PD), and are associated with a lower quality of life. The aim of the current study was to translate the English version of the Scales for Outcomes in Parkinson's Disease-Sleep (SCOPA-S) into the Korean version of SCOPA-S (K-SCOPA-S), and to evaluate its reliability and validity for use by Korean-speaking patients with PD. METHODS: In total, 136 patients with PD from 27 movement disorder centres of university-affiliated hospitals in Korea were enrolled in this study...
January 8, 2018: Journal of Korean Medical Science
Victor M Vergara, Barbara J Weiland, Kent Hutchison, Vince D Calhoun
Alcohol, nicotine and cannabis are among the most commonly used drugs. A prolonged and combined use of these substances can alter normal brain wiring in different ways depending on the consumed cocktail mixture. Brain connectivity alterations and their change with time can be assessed using functional magnetic resonance imaging (fMRI) because of its spatial and temporal content. Here, we estimated dynamic functional network connectivity (dFNC) as derived from fMRI data to investigate the effects of single or combined use of alcohol, nicotine and cannabis...
November 14, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Mads V Lind, Lotte Lauritzen, Oluf Pedersen, Henrik Vestergaard, Ken D Stark, Torben Hansen, Alastair B Ross, Mette Kristensen
Several B-vitamins act as co-factors in one-carbon metabolism, a pathway that plays a central role in several chronic diseases. However, there is a lack of knowledge of how diet affects markers in one-carbon metabolism. The aim of this study was to explore dietary patterns and components associated with one-carbon metabolites. We hypothesized that intake of whole-grains and fish would be associated with lower Hcy, and higher SAM:SAH ratio due to their nutrient content. We assessed dietary information using a four-day dietary record in 118 men and women with features of the metabolic syndrome...
October 2017: Nutrition Research
Mads Brix Kronborg, Jens Brock Johansen, Jens Haarbo, Sam Riahi, Berit Thornvig Philbert, Ole Dan Jørgensen, Jens Cosedis Nielsen
Aims: To evaluate the impact of different right and left ventricular lead positions (RV-LP and LV-LP) on the risk of therapy for ventricular tachycardia/ventricular fibrillation in patients with a cardiac resynchronization therapy device (CRT-D). Methods and results: We performed a large nationwide cohort study on patients in Denmark receiving a CRT-D device from 2008 to 2012 from the Danish Pacemaker and implantable cardioverter defibrillator (ICD) registry. Lead positions were registered during the implantation and categorized as anterior/lateral/posterior and basal/mid-ventricular/apical for the LV-LP, and as apical/non-apical for the RV-LP...
September 27, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Mads Brix Kronborg, Jens Brock Johansen, Sam Riahi, Helen Hoegh Petersen, Jens Haarbo, Ole Dan Jørgensen, Jens Cosedis Nielsen
Aims: To evaluate the association between an apical vs. non-apical right ventricular lead position (RV-LP) and clinical outcome in a large nationwide cohort of patients treated with cardiac resynchronization therapy (CRT). Methods and results: We included consecutive Danish patients receiving a CRT device from 2008 to 2012, identified from the Danish Pacemaker and ICD Register. Endpoints were mortality, mortality or hospitalization for heart failure (HF), and clinical response (improvement ≥1 New York Heart Association class at follow-up)...
March 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Mette Ø Agerbaek, Marina A Pereira, Thomas M Clausen, Caroline Pehrson, Htoo Zarni Oo, Charlotte Spliid, Jamie R Rich, Vincent Fung, Francis Nkrumah, Janet Neequaye, Robert J Biggar, Steven J Reynolds, Giovanna Tosato, Sheeja T Pullarkat, Leona W Ayers, Thor G Theander, Mads Daugaard, Kishor Bhatia, Morten A Nielsen, Sam M Mbulaiteye, Ali Salanti
Burkitt lymphoma (BL) is a malignant disease, which is frequently found in areas with holoendemic Plasmodium falciparum malaria. We have previously found that the VAR2CSA protein is present on malaria-infected erythrocytes and facilitates a highly specific binding to the placenta. ofCS is absent in other non-malignant tissues and thus VAR2CSA generally facilitates parasite sequestration and accumulation in pregnant women. In this study, we show that the specific receptor for VAR2CSA, the oncofetal chondroitin sulfate (ofCS), is likewise present in BL tissue and cell lines...
April 1, 2017: International Journal of Cancer. Journal International du Cancer
Nada Lallous, Eric Leblanc, Ravi S N Munuganti, Mohamed D H Hassona, Nader Al Nakouzi, Shannon Awrey, Helene Morin, Mani Roshan-Moniri, Kriti Singh, Sam Lawn, Takeshi Yamazaki, Hans H Adomat, Christophe Andre, Mads Daugaard, Robert N Young, Emma S Tomlinson Guns, Paul S Rennie, Artem Cherkasov
The development of new antiandrogens, such as enzalutamide, or androgen synthesis inhibitors like abiraterone has improved patient outcomes in the treatment of advanced prostate cancer. However, due to the development of drug resistance and tumor cell survival, a majority of these patients progress to the refractory state of castration-resistant prostate cancer (CRPC). Thus, newer therapeutic agents and a better understanding of their mode of action are needed for treating these CRPC patients. We demonstrated previously that targeting the Binding Function 3 (BF3) pocket of the androgen receptor (AR) has great potential for treating patients with CRPC...
December 2016: Molecular Cancer Therapeutics
Mads Brix Kronborg, Jens Brock Johansen, Sam Riahi, Helen Hoegh Petersen, Jens Haarbo, Ole Dan Jørgensen, Jens Cosedis Nielsen
BACKGROUND: Non-response to cardiac resynchronization therapy (CRT) might be due to insufficient resynchronization as a result of a sub-optimal left ventricular lead positon (LV-LP). OBJECTIVE: To evaluate the impact of different LV-LPs on mortality and symptomatic improvement in a large cohort of patients treated with CRT. METHODS: We performed a nationwide cohort study on consecutive patients receiving a CRT device from 1997 to 2012 registered in the Danish pacemaker and ICD register...
November 1, 2016: International Journal of Cardiology
Youbong Hyun, René Richter, Coral Vincent, Rafael Martinez-Gallegos, Aimone Porri, George Coupland
Flowering is initiated in response to environmental and internal cues that are integrated at the shoot apical meristem (SAM). We show that SPL15 coordinates the basal floral promotion pathways required for flowering of Arabidopsis in non-inductive environments. SPL15 directly activates transcription of the floral regulators FUL and miR172b in the SAM during floral induction, whereas its paralog SPL9 is expressed later on the flanks of the SAM. The capacity of SPL15 to promote flowering is regulated by age through miR156, which targets SPL15 mRNA, and gibberellin (GA), which releases SPL15 from DELLAs...
May 9, 2016: Developmental Cell
Yunfeng Liu, Dajian Zhang, Jieqing Ping, Shuai Li, Zhixiang Chen, Jianxin Ma
It has been demonstrated that Terminal Flowering 1 (TFL1) in Arabidopsis and its functional orthologs in other plants specify indeterminate stem growth through their specific expression that represses floral identity genes in shoot apical meristems (SAMs), and that the loss-of-function mutations at these functional counterparts result in the transition of SAMs from the vegetative to reproductive state that is essential for initiation of terminal flowering and thus formation of determinate stems. However, little is known regarding how semi-determinate stems, which produce terminal racemes similar to those observed in determinate plants, are specified in any flowering plants...
January 2016: PLoS Genetics
Rigoberto V Pérez-Ruiz, Berenice García-Ponce, Nayelli Marsch-Martínez, Yamel Ugartechea-Chirino, Mitzi Villajuana-Bonequi, Stefan de Folter, Eugenio Azpeitia, José Dávila-Velderrain, David Cruz-Sánchez, Adriana Garay-Arroyo, María de la Paz Sánchez, Juan M Estévez-Palmas, Elena R Álvarez-Buylla
In Arabidopsis thaliana, multiple genes involved in shoot apical meristem (SAM) transitions have been characterized, but the mechanisms required for the dynamic attainment of vegetative, inflorescence, and floral meristem (VM, IM, FM) cell fates during SAM transitions are not well understood. Here we show that a MADS-box gene, XAANTAL2 (XAL2/AGL14), is necessary and sufficient to induce flowering, and its regulation is important in FM maintenance and determinacy. xal2 mutants are late flowering, particularly under short-day (SD) condition, while XAL2 overexpressing plants are early flowering, but their flowers have vegetative traits...
May 2015: Molecular Plant
Devinder Kaur, Vivek Dogra, Pooja Thapa, Amita Bhattacharya, Anil Sood, Yelam Sreenivasulu
In Dendrocalamus hamiltonii, conversion of vegetative meristem to a floral meristem was successfully achieved on flower induction medium. A total of 128 differentially expressed proteins were evidenced by 2DE in floral meristem protein profiles. Analysis of 103 proteins through PMF revealed change in abundance in the content of 79 proteins, disappearance and new appearance in the content of 7 and 17 proteins, respectively. MS/MS and subsequent homology search identified 65 proteins that were involved in metabolism (22 proteins), regulatory (11 proteins), signaling and transportation (12 proteins), stress (6 proteins), flowering (8 proteins), and unknown functions (6 proteins)...
April 2015: Proteomics
Lindsay M Morton, Susan L Slager, James R Cerhan, Sophia S Wang, Claire M Vajdic, Christine F Skibola, Paige M Bracci, Silvia de Sanjosé, Karin E Smedby, Brian C H Chiu, Yawei Zhang, Sam M Mbulaiteye, Alain Monnereau, Jennifer J Turner, Jacqueline Clavel, Hans-Olov Adami, Ellen T Chang, Bengt Glimelius, Henrik Hjalgrim, Mads Melbye, Paolo Crosignani, Simonetta di Lollo, Lucia Miligi, Oriana Nanni, Valerio Ramazzotti, Stefania Rodella, Adele Seniori Costantini, Emanuele Stagnaro, Rosario Tumino, Carla Vindigni, Paolo Vineis, Nikolaus Becker, Yolanda Benavente, Paolo Boffetta, Paul Brennan, Pierluigi Cocco, Lenka Foretova, Marc Maynadié, Alexandra Nieters, Anthony Staines, Joanne S Colt, Wendy Cozen, Scott Davis, Anneclaire J de Roos, Patricia Hartge, Nathaniel Rothman, Richard K Severson, Elizabeth A Holly, Timothy G Call, Andrew L Feldman, Thomas M Habermann, Mark Liebow, Aaron Blair, Kenneth P Cantor, Eleanor V Kane, Tracy Lightfoot, Eve Roman, Alex Smith, Angela Brooks-Wilson, Joseph M Connors, Randy D Gascoyne, John J Spinelli, Bruce K Armstrong, Anne Kricker, Theodore R Holford, Qing Lan, Tongzhang Zheng, Laurent Orsi, Luigino Dal Maso, Silvia Franceschi, Carlo La Vecchia, Eva Negri, Diego Serraino, Leslie Bernstein, Alexandra Levine, Jonathan W Friedberg, Jennifer L Kelly, Sonja I Berndt, Brenda M Birmann, Christina A Clarke, Christopher R Flowers, James M Foran, Marshall E Kadin, Ora Paltiel, Dennis D Weisenburger, Martha S Linet, Joshua N Sampson
BACKGROUND: Non-Hodgkin lymphoma (NHL) comprises biologically and clinically heterogeneous subtypes. Previously, study size has limited the ability to compare and contrast the risk factor profiles among these heterogeneous subtypes. METHODS: We pooled individual-level data from 17 471 NHL cases and 23 096 controls in 20 case-control studies from the International Lymphoma Epidemiology Consortium (InterLymph). We estimated the associations, measured as odds ratios, between each of 11 NHL subtypes and self-reported medical history, family history of hematologic malignancy, lifestyle factors, and occupation...
August 2014: Journal of the National Cancer Institute. Monographs
Lindsay M Morton, Joshua N Sampson, James R Cerhan, Jennifer J Turner, Claire M Vajdic, Sophia S Wang, Karin E Smedby, Silvia de Sanjosé, Alain Monnereau, Yolanda Benavente, Paige M Bracci, Brian C H Chiu, Christine F Skibola, Yawei Zhang, Sam M Mbulaiteye, Michael Spriggs, Dennis Robinson, Aaron D Norman, Eleanor V Kane, John J Spinelli, Jennifer L Kelly, Carlo La Vecchia, Luigino Dal Maso, Marc Maynadié, Marshall E Kadin, Pierluigi Cocco, Adele Seniori Costantini, Christina A Clarke, Eve Roman, Lucia Miligi, Joanne S Colt, Sonja I Berndt, Andrea Mannetje, Anneclaire J de Roos, Anne Kricker, Alexandra Nieters, Silvia Franceschi, Mads Melbye, Paolo Boffetta, Jacqueline Clavel, Martha S Linet, Dennis D Weisenburger, Susan L Slager
BACKGROUND: Non-Hodgkin lymphoma (NHL), the most common hematologic malignancy, consists of numerous subtypes. The etiology of NHL is incompletely understood, and increasing evidence suggests that risk factors may vary by NHL subtype. However, small numbers of cases have made investigation of subtype-specific risks challenging. The International Lymphoma Epidemiology Consortium therefore undertook the NHL Subtypes Project, an international collaborative effort to investigate the etiologies of NHL subtypes...
August 2014: Journal of the National Cancer Institute. Monographs
Jieqing Ping, Yunfeng Liu, Lianjun Sun, Meixia Zhao, Yinghui Li, Maoyun She, Yi Sui, Feng Lin, Xiaodong Liu, Zongxiang Tang, Hanh Nguyen, Zhixi Tian, Lijuan Qiu, Randall L Nelson, Thomas E Clemente, James E Specht, Jianxin Ma
Similar to Arabidopsis thaliana, the wild soybeans (Glycine soja) and many cultivars exhibit indeterminate stem growth specified by the shoot identity gene Dt1, the functional counterpart of Arabidopsis TERMINAL FLOWER1 (TFL1). Mutations in TFL1 and Dt1 both result in the shoot apical meristem (SAM) switching from vegetative to reproductive state to initiate terminal flowering and thus produce determinate stems. A second soybean gene (Dt2) regulating stem growth was identified, which, in the presence of Dt1, produces semideterminate plants with terminal racemes similar to those observed in determinate plants...
July 2014: Plant Cell
Jacob Bauer, Gabriela Ondrovičová, Lucie Najmanová, Vladimír Pevala, Zdeněk Kameník, Július Koštan, Jiří Janata, Eva Kutejová
The S-adenosyl-L-methionine (SAM)-dependent methyltransferase CcbJ from Streptomyces caelestis catalyzes one of the final steps in the biosynthesis of the antibiotic celesticetin, methylation of the N atom of its proline moiety, which greatly enhances the activity of the antibiotic. Since several celesticetin variants exist, this enzyme may be able to act on a variety of substrates. The structures of CcbJ determined by MAD phasing at 3.0 Å resolution, its native form at 2.7 Å resolution and its complex with S-adenosyl-L-homocysteine (SAH) at 2...
April 2014: Acta Crystallographica. Section D, Biological Crystallography
Zhongye He, Renxuan Guo, Chengyao Xie, Nan Liu, Yang Li, Wen Song
In order to explore the effects of retrograde infusion of chondroitin-sulfate via the pancreatic duct on cytoprotection and attenuation of oxidative damage during acute necrotic pancreatitis (ANP), male Wistar rats were randomly divided into three groups: A, B (experimental groups) and C (sham operation, control group). The rats in group A was subjected to retrograde injection of 5% sodium taurocholate via the pancreatic duct, and those in group B received chondroitin-sulfate therapy after ANP induction. All rats in three groups were killed at 6 h...
February 2007: Frontiers of Medicine in China
Gillian I Rice, Gabriella M A Forte, Marcin Szynkiewicz, Diana S Chase, Alec Aeby, Mohamed S Abdel-Hamid, Sam Ackroyd, Rebecca Allcock, Kathryn M Bailey, Umberto Balottin, Christine Barnerias, Genevieve Bernard, Christine Bodemer, Maria P Botella, Cristina Cereda, Kate E Chandler, Lyvia Dabydeen, Russell C Dale, Corinne De Laet, Christian G E L De Goede, Mireia Del Toro, Laila Effat, Noemi Nunez Enamorado, Elisa Fazzi, Blanca Gener, Madli Haldre, Jean-Pierre S-M Lin, John H Livingston, Charles Marques Lourenco, Wilson Marques, Patrick Oades, Pärt Peterson, Magnhild Rasmussen, Agathe Roubertie, Johanna Loewenstein Schmidt, Stavit A Shalev, Rogelio Simon, Ronen Spiegel, Kathryn J Swoboda, Samia A Temtamy, Grace Vassallo, Catheline N Vilain, Julie Vogt, Vanessa Wermenbol, William P Whitehouse, Doriette Soler, Ivana Olivieri, Simona Orcesi, Mona S Aglan, Maha S Zaki, Ghada M H Abdel-Salam, Adeline Vanderver, Kai Kisand, Flore Rozenberg, Pierre Lebon, Yanick J Crow
BACKGROUND: Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR). The disease is severe and effective treatments are urgently needed. We investigated the status of interferon-related biomarkers in patients with AGS with a view to future use in diagnosis and clinical trials. METHODS: In this case-control study, samples were collected prospectively from patients with mutation-proven AGS...
December 2013: Lancet Neurology
Do-Young Kwon, Jae Woo Kim, Hyeo-Il Ma, Tae-Beom Ahn, Jinwhan Cho, Phil Hyu Lee, Sun Ju Chung, Joong-Seok Kim, Jong Sam Baik, Seong-Beom Koh
BACKGROUND AND PURPOSE: The importance of health-related quality of life (HrQoL) has been increasingly emphasized when assessing and providing treatment to patients with chronic, progressive, degenerative disorders. The 39-item Parkinson's disease questionnaire (PDQ-39) is the most widely used patient-reporting scale to assess HrQoL in Parkinson's disease (PD). This study evaluated the validity and reliability of the translated Korean version of the PDQ-39 (K-PDQ-39). METHODS: One hundred and two participants with PD from 10 movement disorder clinics at university-affiliated hospitals in South Korea completed the K-PDQ-39...
January 2013: Journal of Clinical Neurology
Seong-Beom Koh, Jae Woo Kim, Hyeo-Il Ma, Tae-Beom Ahn, Jin Whan Cho, Phil Hyu Lee, Sun Ju Chung, Joong-Seok Kim, Do Young Kwon, Jong Sam Baik
BACKGROUND AND PURPOSE: Non-motor symptoms are common in Parkinson's disease (PD), and are the primary cause of disability in many PD patients. Our aim in this study was to translate the origin non-motor symptoms scale for PD (NMSS), which was written in English, into Korean (K-NMSS), and to evaluate its reliability and validity for use with Korean-speaking patients with PD. METHODS: In total, 102 patients with PD from 9 movement disorders sections of university teaching hospitals in Korea were enrolled in this study...
December 2012: Journal of Clinical Neurology
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