keyword
https://read.qxmd.com/read/38537071/metabolic-tumor-burden-as-a-prognostic-indicator-after-neoadjuvant-chemotherapy-in-pancreatic-cancer
#1
JOURNAL ARTICLE
Woohyung Lee, Minyoung Oh, Jae Seung Kim, Minkyu Sung, Kwangpyo Hong, Bong Jun Kwak, Yejong Park, Eunsung Jun, Ki Byung Song, Dae Wook Hwang, Jae Hoon Lee, Changhoon Yoo, Kyu-Pyo Kim, Inkeun Park, Jae Ho Jeong, Heung-Moon Chang, Baek-Yeol Ryoo, Jung Bok Lee, Song Cheol Kim
BACKGROUND: There is no standardized assessment for evaluating response although neoadjuvant chemotherapy (NAT) is widely accepted for borderline resectable or locally advanced pancreatic cancer (BRPC or LAPC). This study was aimed to evaluate NAT response using positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro-D-glucose (18F-FDG-PET/CT) parameters alongside carbohydrate antigen (CA) 19-9 levels. METHODS: Patients who underwent surgery after NAT for BRPC and LAPC between 2017 and 2021 were identified...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536511/repeatability-of-18-f-fdg-uptake-in-metastatic-bone-lesions-of-breast-cancer-patients-and-implications-for-accrual-to-clinical-trials
#2
JOURNAL ARTICLE
Mark Muzi, Lanell M Peterson, Jennifer M Specht, Daniel S Hippe, Alena Novakova-Jiresova, Jean H Lee, Brenda F Kurland, David A Mankoff, Nancy Obuchowski, Hannah M Linden, Paul E Kinahan
BACKGROUND: Standard measures of response such as Response Evaluation Criteria in Solid Tumors are ineffective for bone lesions, often making breast cancer patients that have bone-dominant metastases ineligible for clinical trials with potentially helpful therapies. In this study we prospectively evaluated the test-retest uptake variability of 2-deoxy-2-[18F]fluoro-D-glucose (18 F-FDG) in a cohort of breast cancer patients with bone-dominant metastases to determine response criteria. The thresholds for 95% specificity of change versus no-change were then applied to a second cohort of breast cancer patients with bone-dominant metastases...
March 27, 2024: EJNMMI Research
https://read.qxmd.com/read/38528239/increased-lesion-detectability-in-patients-with-locally-advanced-breast-cancer-a-pilot-study-using-dynamic-whole-body-18-f-fdg-pet-ct
#3
JOURNAL ARTICLE
Mette Abildgaard Pedersen, André H Dias, Karin Hjorthaug, Lars C Gormsen, Joan Fledelius, Anna Lyhne Johnsson, Signe Borgquist, Trine Tramm, Ole Lajord Munk, Mikkel Holm Vendelbo
BACKGROUND: Accurate diagnosis of axillary lymph node (ALN) metastases is essential for prognosis and treatment planning in breast cancer. Evaluation of ALN is done by ultrasound, which is limited by inter-operator variability, and by sentinel lymph node biopsy and/or ALN dissection, none of which are without risks and/or long-term complications. It is known that conventional 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography/computed tomography (PET/CT) has limited sensitivity for ALN metastases...
March 25, 2024: EJNMMI Research
https://read.qxmd.com/read/38521838/hypercalcemia-as-a-rare-manifestation-of-immune-reconstitution-inflammatory-syndrome-iris-in-a-person-living-with-human-immunodeficiency-virus-hiv-with-disseminated%C3%A2-nontuberculous-mycobacteriosis
#4
JOURNAL ARTICLE
Maximilian Webendoerfer, Margarethe Konik, Markus Zettler, Johannes Wienker, Josefine Rawitzer, Stefan Esser, Jan Kehrmann, Ken Herrmann, Hans Christian Reinhardt, Oliver Witzke, Sebastian Dolff
INTRODUCTION: Granulomatosis due to immune reconstitution inflammatory syndrome (IRIS) and disseminated Mycobacterium avium-intracellulare (M. avium) infection may trigger hypercalcemia. Here, we report a rare case of hypercalcemia and acute kidney damage related to IRIS in a person living with Human Immunodeficiency Virus (HIV). CASE PRESENTATION: A 39-year-old male person living with HIV presented with muscle weakness and unwanted weight loss of 8 kg within the last 2 weeks...
March 23, 2024: Infection
https://read.qxmd.com/read/38519820/end-of-treatment-18-f-fdg-pet-can-predict-early-progression-in-patients-receiving-bendamustine-rituximab-for-follicular-lymphoma-in-first-relapse-a-prospective-west-japan-hematology-study-group-w-jhs-nhl01-trial
#5
JOURNAL ARTICLE
Koji Kato, Koji Izutsu, Momoko Nishikori, Hirohiko Shibayama, Yoshinobu Maeda, Kenichi Yoshimura, Ukihide Tateishi, Toshihiro Miyamoto, Yasufumi Matsuda, Jun Ishikawa, Shinya Rai, Tsutomu Takahashi, Takahiro Yamauchi, Itaru Matsumura, Koichi Akashi, Yuzuru Kanakura, Junji Suzumiya
Response determined by 18[F]-fluoro-2-deoxy-D-glucose (18 F-FDG) positron emission tomography (PET)-CT after induction therapy can predict progression-free survival (PFS) in follicular lymphoma (FL). However, little prospective research has examined the significance of PET after second-line therapy. We conducted a prospective multicenter phase II trial (W-JHS NHL01) of bendamustine plus rituximab (BR) without rituximab maintenance for FL in first relapse. This study aimed to evaluate the usefulness of end-of-treatment (EOT)-PET for predicting PFS in FL patients in first relapse...
March 22, 2024: International Journal of Hematology
https://read.qxmd.com/read/38516858/sensitive-detection-of-herbicide-residues-using-field-amplified-sample-injection-coupled-with-electrokinetic-supercharging-in-flow-gated-capillary-electrophoresis
#6
JOURNAL ARTICLE
Ying Gong, Maojun Gong
Residues of glyphosate (GlyP) and its major degradation product, aminomethylphosphonic acid (AMPA), widely exist in the water system and plant products and thus are also present in the bodies of animals and humans. Although no solid evidence has been obtained, the concern about the cancer risk of GlyP is persistent. The measurement of GlyP and AMPA in trace levels is often needed but lacks readily available analytical approaches with detection sensitivity, accuracy and speed. This study aims to develop a simple and robust technique for the sensitive detection of GlyP and AMPA residues in a surface water system with flow-gated capillary electrophoresis (CE)...
March 22, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38511197/the-mediating-effect-of-18-f-fdg-metabolism-in-right-caudate-between-depressive-symptoms-and-cognitive-function-in-alzheimer-s-disease
#7
JOURNAL ARTICLE
Bojun Wang, Chunlei Cui, Yifan Chen, Zhigang Liang
PURPOSE: The objective of this study was to investigate the accumulation of 18 F-fluorodeoxyglucose (18 F-FDG) in the whole brain between Alzheimer's disease (AD) with depressive (ADD) symptoms compared with AD without depressive (ADND) symptoms using positron emission tomography/magnetic resonance imaging (PET/MRI). Additionally, this study aimed to explore the associations among the accumulation of 18 F-FDG in the brain, depressive symptoms, and cognitive function in ADD patients. METHODS: In this study, 25 AD patients and 22 healthy controls were enrolled...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38505972/immunoglobulin-g-immunoglobulin-m-autoantibody-ratios-in-incomplete-systemic-lupus-erythematosus
#8
JOURNAL ARTICLE
S Henning, J Westra, C Roozendaal, G Haarsma-de Boer, J J Fierro, B Horvath, H Bootsma, K de Leeuw
OBJECTIVE: Immunoglobulin G (IgG) autoantibodies in systemic lupus erythematosus (SLE) are considered pathogenic, whereas immunoglobulin M (IgM) autoantibodies may have protective effects. The aim of this study was to identify whether IgG/IgM autoantibody ratios differ between patients with incomplete systemic lupus erythematosus (iSLE), patients with SLE, and healthy controls (HCs), and whether IgG/IgM autoantibody ratios relate to progression from iSLE to SLE. METHOD: This prospective cohort study included 34 iSLE patients, 41 SLE patients, and 11 HCs...
March 20, 2024: Scandinavian Journal of Rheumatology
https://read.qxmd.com/read/38505325/fluorinated-analogues-to-the-pentuloses-of-the-pentose-phosphate-pathway
#9
JOURNAL ARTICLE
Lukas Scheibelberger, Toda Stankovic, Kaja Liepert, Andreas Kienzle, Eva-Maria Patronas, Theresa Balber, Markus Mitterhauser, Arvand Haschemi, Katharina Pallitsch
Fluorinated carbohydrates are valuable tools for enzymological studies due to their increased metabolic stability compared to their non-fluorinated analogues. Replacing different hydroxyl groups within the same monosaccharide by fluorine allows to influence a wide range of sugar-receptor interactions and enzymatic transformations. In the past, this principle was frequently used to study the metabolism of highly abundant carbohydrates, while the metabolic fate of rare sugars is still poorly studied. Rare sugars, however, are key intermediates of many metabolic routes, such as the pentose phosphate pathway (PPP)...
August 14, 2023: European Journal of Organic Chemistry
https://read.qxmd.com/read/38502056/the-effects-of-the-%C3%AE-1-adrenergic-receptor-antagonist-bisoprolol-administration-on-mirabegron-stimulated-human-brown-adipose-tissue-thermogenesis
#10
JOURNAL ARTICLE
Lauralyne Dumont, Alexandre Caron, Gabriel Richard, Etienne Croteau, Mélanie Fortin, Frédérique Frisch, Serge Phoenix, Stéphanie Dubreuil, Brigitte Guérin, Éric E Turcotte, André C Carpentier, Denis P Blondin
AIM: Pharmacological stimulation of human brown adipose tissue (BAT) has been hindered by ineffective activation or undesirable off-target effects. Oral administration of the maximal allowable dose of mirabegron (200 mg), a β3 -adrenergic receptor (β3 -AR) agonist, has been effective in stimulating BAT thermogenesis and whole-body energy expenditure. However, this has been accompanied by undesirable cardiovascular effects. Therefore, we hypothesized that combining mirabegron with a β1 -AR antagonist could suppress these unwanted effects and increase the stimulation of the β3 -AR and β2 -AR in BAT...
March 19, 2024: Acta Physiologica
https://read.qxmd.com/read/38501888/structural-insights-on-the-role-of-halogen-bonding-in-protein-mek-kinase-inhibitor-complexes
#11
REVIEW
Pietro Milesi, Francesca Baldelli Bombelli, Luisa Lanfrancone, Rosa M Gomila, Antonio Frontera, Pierangelo Metrangolo, Giancarlo Terraneo
Kinases are enzymes that play a critical role in governing essential biological processes. Due to their pivotal involvement in cancer cell signaling, they have become key targets in the development of anti-cancer drugs. Among these drugs, those containing the 2,4-dihalophenyl moiety demonstrated significant potential. Here we show how this moiety, particularly the 2-fluoro-4-iodophenyl one, is crucial for the structural stability of the formed drug-enzyme complexes. Crystallographic analysis of reported kinase-inhibitor complex structures highlights the role of the halogen bonding that this moiety forms with specific residues of the kinase binding site...
March 19, 2024: Chemistry, An Asian Journal
https://read.qxmd.com/read/38498197/associations-of-pyrethroid-exposure-with-bone-mineral-density-and-osteopenia-in-adults
#12
JOURNAL ARTICLE
Zhubin Shen, Fengyi Zhang, Xiaoqing Guan, Zhiming Liu, Yuan Zong, Ding Zhang, Rui Wang, Qian Xue, Wenxuan Ma, Ruijian Zhuge, Li Guo, Fei Yin
INTRODUCTION: This study was to investigate the correlations between pyrethroid exposure and bone mineral density (BMD) and osteopenia. MATERIALS AND METHODS: This cross-sectional study included 1389 participants over 50 years of age drawn from the 2007-2010 and 2013-2014 National Health and Nutrition Examination Survey (NHANES). Three pyrethroid metabolites, 3-phenoxybenzoic acid (3-PBA), trans-3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropane-1-carboxylic acid (trans-DCCA), and 4-fluoro-3-phenoxybenzoic acid (4-F-3PBA) were used as indicators of pyrethroid exposure...
March 18, 2024: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/38497715/combining-fecal-microbiome-and-metabolomics-reveals-diagnostic-biomarkers-for-esophageal-squamous-cell-carcinoma
#13
JOURNAL ARTICLE
Mingjun Gao, Jun Wu, Siding Zhou, Yong Chen, Mengmeng Wang, Wenbo He, Lei Jiang, Yusheng Shu, Xiaolin Wang
Esophageal squamous cell carcinoma (ESCC) is one of the most predominant subtypes of esophageal cancer. The characteristics of the gut microbiome and its metabolites from patients with ESCC have not been adequately studied and discussed. In this study, 40 fecal samples (20 from ESCC patients and 20 from healthy controls) were analyzed by 16S rRNA gene sequencing and untargeted metabolomics. The data sets were analyzed individually and synthesized using various bioinformatics methods. Alpha and beta diversity indicated significant differences in microbial diversity and abundance between ESCC and healthy control feces...
March 18, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38492999/benefits-and-challenges-of-18-f-fdg-pet-ct-in-patients-with-takayasu-arteritis
#14
JOURNAL ARTICLE
Z-H Luo, W-L Qi, A-F Jin, Q-Y Zeng
AIM: To evaluate the diagnostic performance of 2-[18 F]-fluoro-2-deoxy-d-glucose (18 F-FDG) positron-emission tomography (PET)/computed tomography (CT) in TA diagnosis and Takayasu arteritis (TA) activity assessment. MATERIALS AND METHODS: This retrospective study included patients with TA diagnosed according to the American College of Rheumatology (ACR) criteria and undergoing 18 F-FDG PET/CT imaging from October 2010 to July 2022. TA activity was assessed through 18 F-FDG PET/CT (maximum standard uptake value [SUVmax], vascular SUVmax/mean standard uptake value [SUVmean] of liver (SUV ratio), and PET vascular activity score [PETVAS]) using physician global assessment (PGA) as the reference standard, and the results of these assessments were compared against the clinical activity scores (National Institutes of Health [NIH] and Indian Aortitis Disease Activity [ITAS-A] scores), acute-phase reactants (APR), and white blood cell and platelet counts...
February 2, 2024: Clinical Radiology
https://read.qxmd.com/read/38488361/2-bromopalmitate-depletes-lipid-droplets-to-inhibit-viral-replication
#15
JOURNAL ARTICLE
Dongxiao Liu, Ruth Cruz-Cosme, Yong Wu, Julian Leibowitz, Qiyi Tang
UNLABELLED: The global impact of emerging viral infections emphasizes the urgent need for effective broad-spectrum antivirals. The cellular organelle, lipid droplet (LD), is utilized by many types of viruses for replication, but its reduction does not affect cell survival. Therefore, LD is a potential target for developing broad-spectrum antivirals. In this study, we found that 2-bromopalmitate (2 BP), a previously defined palmitoylation inhibitor, depletes LD across all studied cell lines and exerts remarkable antiviral effects on different coronaviruses...
March 15, 2024: Journal of Virology
https://read.qxmd.com/read/38485864/gpr39-agonist-tc-g-1008-promoted-mitochondrial-biogenesis-and-improved-antioxidative-capability-via-creb-pgc-1%C3%AE-pathway-following-intracerebral-hemorrhage-in-mice
#16
JOURNAL ARTICLE
Zhongyi Zhang, Ye Yuan, Xingyu Zhang, Lingui Gu, Yuguang Tang, Yutong Zhao, Jinyu Dai, Yihao Tao, Zongyi Xie
Mitochondrial dysfunction and excessive reactive oxygen species production due to impaired mitochondrial biogenesis have been proven to exacerbate secondary brain injury after intracerebral hemorrhage (ICH). The G-protein-coupled receptor 39 (GPR39) agonist TC-G 1008 has been shown to exert anti-oxidative stress effect in acute hypoxic brain injury. Herein, our study aimed to investigate the potential effects of TC-G 1008 on neuronal mitochondrial biogenesis and antioxidative stress in a mouse model of ICH and explore the underlying mechanisms...
March 15, 2024: Translational Stroke Research
https://read.qxmd.com/read/38483119/pomalidomide-improves-motor-behavioral-deficits-and-protects-cerebral-cortex-and-striatum-against-neurodegeneration-through-a-reduction-of-oxidative-nitrosative-damages-and-neuroinflammation-after-traumatic-brain-injury
#17
JOURNAL ARTICLE
Ya-Ni Huang, Nigel H Greig, Pen-Sen Huang, Yung-Hsiao Chiang, Alan Hoffer, Chih-Hao Yang, David Tweedie, Ying Chen, Ju-Chi Ou, Jia-Yi Wang
Neuronal damage resulting from traumatic brain injury (TBI) causes disruption of neuronal projections and neurotransmission that contribute to behavioral deficits. Cellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is an early event following TBI. ROS often damage DNA, lipids, proteins, and carbohydrates while RNS attack proteins. The products of lipid peroxidation 4-hydroxynonenal (4-HNE) and protein nitration 3-nitrotyrosine (3-NT) are often used as indicators of oxidative and nitrosative damages, respectively...
2024: Cell Transplantation
https://read.qxmd.com/read/38482848/palladium-catalysed-aryl-monofluoroalkylation-of-allenamides-access-to-fluoroalkyl-indoles-and-isoquinolones
#18
JOURNAL ARTICLE
Qiaoli Xue, Yue Pu, Haixia Zhao, Xiaotian Xie, Heng Zhang, Jian Wang, Liqin Yan, Yongjia Shang
A palladium catalysed construction of fluoroalkyl indoles and isoquinolones through aryl/monofluoroalkylation of allenamides has been developed. Monofluoromethyl-substituted heterocycles could be accessed under mild conditions with broad functional group tolerance. In addition, indole-oxindole bisheterocyclic scaffolds bearing a fluorine atom were successfully synthesized with 3-fluoro-oxindole as the nucleophile by applying this method.
March 14, 2024: Chemical Communications: Chem Comm
https://read.qxmd.com/read/38477875/brown-adipose-tissue-metabolism-in-women-is-dependent-on-ovarian-status
#19
JOURNAL ARTICLE
Denis P Blondin, Francois Haman, Tracy M Swibas, Sophie Hogan-Lamarre, Lauralyne Dumont, Jolan Guertin, Gabriel Richard, Quentin Weissenburger, Kerry L Hildreth, Irene E Schauer, Shelby Panter, Liza Wayland, André C Carpentier, Yubin Miao, Jiayun Shi, Elizabeth Jaruez-Colunga, Wendy M Kohrt, Edward L Melanson
In rodents, loss of estradiol (E2 ) reduces brown adipose tissue (BAT) metabolic activity. Whether E2 impacts BAT activity in women is not known. BAT oxidative metabolism was measured in premenopausal (N=27, 35±9 years, body mass index (BMI) = 26.0±5.3 kg/m2 ) and postmenopausal (N=25, 51±8 years, BMI = 28.0±5.0 kg/m2 ) women at room temperature (RT) and during acute cold exposure using [11 C]-acetate with positron emission tomography coupled with computed tomography (PET/CT). BAT glucose uptake was also measured during acute cold exposure using 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG)...
March 13, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38477306/evaluation-of-individual-variation-of-d-amino-acids-in-human-plasma-by-a-two-dimensional-lc-ms-ms-system-and-application-to-the-early-diagnosis-of-chronic-kidney-disease
#20
JOURNAL ARTICLE
Chiharu Ishii, Takeyuki Akita, Tomonori Kimura, Shinsuke Sakai, Masashi Mita, Tomomi Ide, Yoshitaka Isaka, Kenji Hamase
For the discovery of sensitive biomarkers of kidney function focusing on chiral amino acids, a multiple heart-cutting two-dimensional (2D) liquid chromatography-mass spectrometry (LC-MS)/MS system has been designed/developed. As the target analytes, alanine (Ala), aspartic acid, glutamic acid (Glu), leucine (Leu), lysine, methionine, phenylalanine (Phe), proline (Pro), serine (Ser), and valine were selected considering the presence of their d-forms in mammals. The 2D LC-MS/MS system consisted of the nonenantioselective reversed-phase separation of the target amino acids, the separations of the d- and l-enantiomers, and detection using MS/MS...
March 13, 2024: Analytical Chemistry
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