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https://www.readbyqxmd.com/read/28108470/associations-of-maternal-vitamin-b12-concentration-in-pregnancy-with-the-risks-of-preterm-birth-and-low-birth-weight-a-systematic-review-and-meta-analysis-of-individual-participant-data
#1
Tormod Rogne, Myrte J Tielemans, Mary Foong-Fong Chong, Chittaranjan S Yajnik, Ghattu V Krishnaveni, Lucilla Poston, Vincent W V Jaddoe, Eric A P Steegers, Suyog Joshi, Yap-Seng Chong, Keith M Godfrey, Fabian Yap, Raquel Yahyaoui, Tinku Thomas, Gry Hay, Marije Hogeveen, Ahmet Demir, Ponnusamy Saravanan, Eva Skovlund, Marit P Martinussen, Geir W Jacobsen, Oscar H Franco, Michael B Bracken, Kari R Risnes
Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of individual participant data to evaluate the associations of maternal serum or plasma B12 concentrations in pregnancy with offspring birth weight and length of gestation. Twenty-two eligible studies were identified (11,993 observations)...
January 20, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28108103/respiratory-support-for-very-low-birth-weight-infants-receiving-dexamethasone
#2
Yamini V Virkud, Christoph P Hornik, Daniel K Benjamin, Matthew M Laughon, Reese H Clark, Rachel G Greenberg, P Brian Smith
OBJECTIVE: To assess how neonatal intensive care units followed the American Academy of Pediatrics guidelines for use of dexamethasone in preterm infants by evaluating respiratory support at the time of dexamethasone administration. STUDY DESIGN: This is an observational study of infants discharged from one of 290 neonatal intensive care units from 2003 to 2010. The cohort included very low birth weight (<1500 g birth weight) infants born at ≤32 weeks gestational age...
January 18, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28107805/effectiveness-of-an-sms-based-maternal-mhealth-intervention-to-improve-clinical-outcomes-of-hiv-positive-pregnant-women
#3
Jesse Coleman, Kate C Bohlin, Anna Thorson, Vivian Black, Patricia Mechael, Josie Mangxaba, Jaran Eriksen
We conducted a retrospective study to investigate the effectiveness of an mHealth messaging intervention aiming to improve maternal health and HIV outcomes. Maternal health SMSs were sent to 235 HIV-infected pregnant women twice per week in pregnancy and continued until the infant's first birthday. The messages were timed to the stage of the pregnancy/infant age and covered maternal health and HIV-support information. Outcomes, measured as antenatal care (ANC) visits, birth outcomes and infant HIV testing, were compared to a control group of 586 HIV-infected pregnant women who received no SMS intervention...
January 20, 2017: AIDS Care
https://www.readbyqxmd.com/read/28105570/primary-carnitine-deficiency-is-foetal-development-affected-and-can-newborn-screening-be-improved
#4
Jan Rasmussen, David M Hougaard, Noreen Sandhu, Katrine Fjællegaard, Poula R Petersen, Ulrike Steuerwald, Allan M Lund
: Primary carnitine deficiency (PCD) causes low levels of carnitine in patients potentially leading to metabolic and cardiac symptoms. Newborn screening for PCD is now routine in many countries by measuring carnitine levels in infants. In this study we report Apgar scores, length and weight in newborns with PCD and newborns born to mothers with PCD compared to controls. Furthermore we report how effective different screening algorithms have been to detect newborns with PCD in the Faroe Islands...
January 20, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28105544/status-of-birth-outcomes-in-clients-of-the-nurse-family-partnership
#5
William Thorland, Dustin W Currie
Background The Nurse-Family Partnership (NFP) is a national, evidence-based home visiting program currently serving over 30,000 first-time, low-income mothers. Prior to public implementation, three foundational randomized controlled trials demonstrated program effectiveness in achieving beneficial birth, child development, and maternal life-course outcomes. This study describes birth outcomes of contemporary NFP clients compared to a reference cohort, providing the first evidence of program effect on a nation-wide basis during scale-up...
January 19, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28105101/urinary-neutrophil-gelatinase-associated-lipocalin-is-an-early-predictor-of-acute-kidney-injury-in-premature-infants
#6
Ryota Kuribayashi, Hiroshi Suzumura, Toshimi Sairenchi, Yoshiyuki Watabe, Yayoi Tsuboi, George Imataka, Hidemitsu Kurosawa, Osamu Arisaka
Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is produced in response to tubular epithelial injury and is a biomarker of tubulointerstitial injury. The aim of the present study was to examine whether acute kidney injury (AKI) could be predicted by measuring uNGAL in very low-birth weight (VLBW) infants. Forty VLBW infants with birthweight below 1,500 g were enrolled in the present study. uNGAL and serum creatinine (sCre) were measured daily from postnatal days 0 to 8. Infants with sCre ≥1.2 mg/dl were diagnosed with AKI...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28103963/sex-differences-in-early-life-programming-of-the-hypothalamic-pituitary-adrenal-axis-in-humans-suggest-increased-vulnerability-in-females-a-systematic-review
#7
T Carpenter, S M Grecian, R M Reynolds
Fetal glucocorticoid overexposure is a key mechanism linking early development with later-life disease. In humans, low birth weight associates with increased fasting cortisol, hypothalamic-pituitary-adrenal (HPA) axis reactivity, and with cardiovascular risk and cognitive decline. As there are sex differences in these adult diseases, we hypothesized that there may be sex differences in programming of the HPA axis in response to prenatal stressors. We conducted a systematic review following Meta-Analysis of Observational Studies in Epidemiology and Preferred Reporting Items for Systematic Reviews and Meta-Analysis...
January 20, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28103891/a-mixed-methods-assessment-of-barriers-to-maternal-newborn-and-child-health-in-gogrial-west-south-sudan
#8
Lynn Lawry, Covadonga Canteli, Tahina Rabenzanahary, Wartini Pramana
BACKGROUND: Health conditions for mothers, newborns, and children in South Sudan are among the worst worldwide. South Sudan has the highest rate of maternal mortality in the world and despite alarming statistics, few women and children in South Sudan have access to needed healthcare, especially in rural areas. The purpose of this study was to understand the barriers to maternal, newborn and child health in Gogrial West, Warrap State, South Sudan, one of the most underdeveloped states...
January 19, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28103875/effects-of-plasmodium-falciparum-infection-on-umbilical-artery-resistance-and-intrafetal-blood-flow-distribution-a-doppler-ultrasound-study-from-papua-new-guinea
#9
Maria Ome-Kaius, Stephan Karl, Regina Alice Wangnapi, John Walpe Bolnga, Glen Mola, Jane Walker, Ivo Mueller, Holger Werner Unger, Stephen John Rogerson
BACKGROUND: Doppler velocimetry studies of umbilical artery (UA) and middle cerebral artery (MCA) flow help to determine the presence and severity of fetal growth restriction. Increased UA resistance and reduced MCA pulsatility may indicate increased placental resistance and intrafetal blood flow redistribution. Malaria causes low birth weight and fetal growth restriction, but few studies have assessed its effects on uteroplacental and fetoplacental blood flow. METHODS: Colour-pulsed Doppler ultrasound was used to assess UA and MCA flow in 396 Papua New Guinean singleton fetuses...
January 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28103462/low-adherence-to-mediterranean-diet-in-portugal-pregnant-women-nutrition-in-portugal-and-its-repercussions
#10
REVIEW
Luis Pereira-da-Silva, Elisabete Pinto
INTRODUCTION: Portuguese population is drifting away from the Mediterranean diet-like pattern. In this context, the current nutritionalstatus of women of childbearing age and of pregnant Portuguese women and their growing fetuses is critically reviewed. MATERIAL AND METHODS: A narrative critical review was performed on recent published high quality studies assessing diet and nutritional status of women of childbearing age and pregnant women and its influence on the nutritional status of their offspring...
October 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28103309/folate-transporters-in-placentas-from-preterm-newborns-and-their-relation-to-cord-blood-folate-and-vitamin-b12-levels
#11
Erika Castaño, Lorena Caviedes, Sandra Hirsch, Miguel Llanos, Germán Iñiguez, Ana María Ronco
Folate deficiency during pregnancy has been related to low birth weight, preterm (PT) birth and other health risks in the offspring; however, it is unknown whether prematurity is related to low folate transport through the placenta due to altered expression of specific folate transporters. We determined placental expression (mRNA and protein concentrations by RT-qPCR and WB respectively) of specific folate transporters: RFC, PCFT/HCP1 and FOLR1 in chorionic (fetal) and basal (maternal) plates of placentas of PT pregnancies (PT, 32-36 weeks, n = 51)...
2017: PloS One
https://www.readbyqxmd.com/read/28102992/environmental-factors-associated-with-autism-spectrum-disorder-a-scoping-review-for-the-years-2003-2013
#12
M Ng, J G de Montigny, M Ofner, M T Do
INTRODUCTION: The number of children diagnosed with autism spectrum disorder (ASD) has been rapidly rising in the past decade. The etiology of this disorder, however, is largely unknown, although the environmental relative to the genetic contribution is substantial. We conducted a scoping review to comprehensively assess the current state of knowledge of the environmental factors present from preconception to early life associated with ASD, and to identify research gaps. METHODS: We searched electronic databases MEDLINE, PsycINFO and ERIC for articles on potential risk factors or protective factors from the physical and social environments associated with ASD and its subclassifications published between 1 January, 2003, and 12 July, 2013...
January 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28100335/-methods-for-establishing-animal-model-of-bronchopulmonary-dysplasia-and-their-evaluation
#13
Zeng Xiong, Xia Zhou, Shao-Jie Yue
With the development of treatment, the survival rate of premature infants has significantly increased, especially extremely premature infants and very low birth weight infants. This has led to an increase in incidence of bronchopulmonary dysplasia (BPD) year by year. BPD has been one of the most common respiratory system diseases in premature infants, especially the small premature infants. Arrested alveolar development is an important cause of BPD. Therefore, the mechanism of arrested alveolar development and the intervention measures for promoting alveolar development are the focuses of research on BPD...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28100323/-high-risk-factors-and-clinical-characteristics-of-massive-pulmonary-hemorrhage-in-infants-with-extremely-low-birth-weight
#14
Dan Chen, Meng Wang, Xin Wang, Xue-Wei Ding, Rui-Hua Ba, Jian Mao
OBJECTIVE: To explore the high-risk factors and analyze the clinical characteristics of massive pulmonary hemorrhage (MPH) in infants with extremely low birth weight (ELBW). METHODS: Two hundred and eleven ELBW infants were included in this study. Thirty-five ELBW infants who were diagnosed with MPH were labelled as the MPH group, and 176 ELBW infants without pulmonary hemorrhage were labelled as the control group. The differences in clinical characteristics, mortality rate, and incidence of complications between the two groups were analysed...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28100322/-association-between-risk-factors-during-maternal-pregnancy-and-the-neonatal-period-and-childhood-bronchial-asthma
#15
Hui-Qin Zhang, Rui Fan, Jing-Jing Zhang, Xiao-Juan Tao, Xin Sun
OBJECTIVE: To study the association of the risk factors during maternal pregnancy and the neonatal period with childhood bronchial asthma. METHODS: A total of 306 children with asthma (asthma group) and 250 healthy children (control group) were enrolled. Their clinical data during the neonatal period and the maternal data during pregnancy were retrospectively studied. RESULTS: The univariate analysis showed that there were significant differences in the rates of maternal use of antibiotics during pregnancy, use of antibiotics and probiotics during the neonatal period, preterm birth, cesarean section, low birth weight, and breast feeding (>6 months) between the asthma and control groups (P<0...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28099786/labor-intervention-and-outcomes-in-women-who-are-nulliparous-and-obese-comparison-of-nurse-midwife-to-obstetrician-intrapartum-care
#16
Nicole S Carlson, Elizabeth J Corwin, Nancy K Lowe
BACKGROUND: Women who are obese have slower labors than women of normal weight, and show reduced response to interventions designed to speed labor progress like oxytocin augmentation and artificial rupture of membranes. The optimal labor management for these women has not been described. METHODS: This retrospective cohort study compared 2 propensity score-matched groups of women (N = 360) who were healthy, nulliparous, spontaneously laboring, and obese (body mass index ≥ 30 kg/m(2) )...
January 18, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28099740/association-of-previous-severe-low-birth-weight-with-adverse-perinatal-outcomes-in-a-subsequent-pregnancy-among-hiv-prevalent-urban-african-women
#17
Marcela C Smid, Yusuf Ahmed, Marie C D Stoner, Bellington Vwalika, Elizabeth M Stringer, Jeffrey S A Stringer
OBJECTIVE: To evaluate the association between severity of prior low birth weight (LBW) delivery and adverse perinatal outcomes in the subsequent delivery among an HIV-prevalent urban African population. METHODS: A retrospective cohort study was conducted among 41 109 women who had undergone two deliveries in Lusaka, Zambia, between February 1, 2006, and May 31, 2013. The relationship between prior LBW delivery (<2500 g) and a composite measure of adverse perinatal outcome in the second pregnancy was assessed using multivariate logistic regression...
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099450/advanced-neonatal-medicine-in-china-a-national-baseline-database
#18
Xiang-Peng Liao, Selma Chipenda-Dansokho, Antoine Lewin, Nadia Abdelouahab, Shu-Qin Wei
Previous surveys of neonatal medicine in China have not collected comprehensive information on workforce, investment, health care practice, and disease expenditure. The goal of the present study was to develop a national database of neonatal care units and compare present outcomes data in conjunction with health care practices and costs. We summarized the above components by extracting data from the databases of the national key clinical subspecialty proposals issued by national health authority in China, as well as publicly accessible databases...
2017: PloS One
https://www.readbyqxmd.com/read/28099428/biomarkers-of-adiposity-are-elevated-in-preterm-very-low-birth-weight-infants-at-1-2-and-3-years-of-age
#19
Andrea F Duncan, Joshua A Frankfurt, Roy J Heyne, Charles R Rosenfeld
BACKGROUND: Preterm, very-low-birth-weight (PT-VLBW) neonates are at-risk for metabolic syndrome later in life. At 1-3yrs, they exhibit excessive weight-for-length z-scores (Wt-LZ) and elevated systolic blood pressures (SBP). Serum adipokines are biomarkers of adiposity, but expression in PT-VLBW infants is unclear. We examined the correlation between serum adipokine levels, anthropometric measures and SBP in PT-VLBW neonates at follow-up. METHODS: This was a cross-sectional cohort study of PT-VLBW infants at 1, 2 and 3yrs of age (40/cohort)...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28099423/high-dose-erythropoietin-population-pharmacokinetics-in-neonates-with-hypoxic-ischemic-encephalopathy-receiving-hypothermia
#20
Adam Frymoyer, Sandra E Juul, An N Massaro, Theo K Bammler, Yvonne W Wu
BACKGROUND: High-dose erythropoietin (Epo) is a promising neuroprotective treatment in neonates with hypoxic ischemic encephalopathy (HIE) receiving hypothermia. We evaluated the pharmacokinetics and dose-exposure relationships of high-dose Epo in this population to inform future dosing strategies. METHODS: We performed a population pharmacokinetic analysis of 47 neonates with HIE treated with hypothermia who received up to 6 doses of Epo in two previous clinical trials...
January 18, 2017: Pediatric Research
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