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https://www.readbyqxmd.com/read/28994249/molecular-pathways-of-estrogen-receptors-and-%C3%AE-adrenergic-receptors-in-cardiac-cells-recognition-of-their-similarities-interactions-and-therapeutic-value
#1
REVIEW
Machuki Ong'achwa Jeremiah, Hong-Yuan Zhang, Sian Harding, Hong Sun
Estrogen receptors (ERs) and β-adrenergic receptors (βARs) play important roles in the cardiovascular system. Moreover, these receptors are expressed in cardiac myocytes and vascular tissues. Numerous experimental observations support the hypothesis that similarities and interactions exist between the signaling pathways of ERs (ERα, ERβ, GPR30) and βARs (β1 , β2 , and β3 AR). The recently discovered estrogen receptor GPR30 shares structural features with the βARs, and this forms the basis for the interactions and functional overlap...
October 9, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28955981/a-relation-between-osteoclastogenesis-inhibition-and-membrane-type-estrogen-receptor-gpr30
#2
Masaaki Masuhara, Takao Tsukahara, Kazuo Tomita, Minami Furukawa, Shouichi Miyawaki, Tomoaki Sato
Disruption of the cooperative balance between osteoblasts and osteoclasts causes various bone disorders, some of which are because of abnormal osteoclast recruitment. Osteoporosis, one of the bone disorders, is not effectively treated by currently available medicines. In addition to the development of novel drugs for palliative treatment, the exploitation of novel compounds for preventive treatment is important in an aging society. Quercetin, a major flavonoid found in many fruits and vegetables, has been expected to inhibit cancer and prevent several diseases because of its anti-inflammatory and estrogenic functions...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28935720/suppression-of-store-operated-ca-2-entry-by-activation-of-gper-contribution-to-a-clamping-effect-on-endothelial-ca-2-signaling
#3
Lara E Terry, Mark VerMeer, Jennifer Giles, Quang-Kim Tran
The G Protein-coupled Estrogen Receptor 1 (GPER, formerly a.k.a. GPR30) modulates many Ca(2+)-dependent activities in endothelial cells. However, the underlying mechanisms are poorly understood. We recently reported that GPER acts to prolong cytoplasmic Ca(2+) signals by interacting with and promoting inhibitory phosphorylation of the plasma membrane Ca(2+)-ATPase. In this study, we examined the role of GPER activation in modulating store-operated Ca(2+) entry (SOCE) via effects on the Stromal Interaction Molecule 1 (STIM1)...
September 21, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28924735/the-g-protein-coupled-estrogen-receptor-gper-gpr30-may-serve-as-a-prognostic-marker-in-early-stage-cervical-cancer
#4
Klaus Friese, Bernd Kost, Aurelia Vattai, Frederik Marmé, Christina Kuhn, Sven Mahner, Christian Dannecker, Udo Jeschke, Sabine Heublein
BACKGROUND: Estrogen signalling is transmitted via various receptors and multiple intracellular signalling pathways. Estrogen receptor alpha (ERα)-mediated transcription of target genes has been demonstrated to be closely linked to human papilloma virus (HPV)-induced carcinogenesis in case of cervical cancer. So far, the role of non-genomic estrogen signals in cervical cancer, e.g. transmitted by the G protein-coupled estrogen receptor (GPER) remains to be rather elusive. Today's knowledge on the role of GPER in cervical cancer is sparse and-to the best of our knowledge-GPER has not been investigated in context with clinicopathological parameters or prognosis of cervical cancer...
September 18, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28882636/bisphenol-a-and-estrogen-induce-proliferation-of-human-thyroid-tumor-cells-via-an-estrogen-receptor-dependent-pathway
#5
YongHong Zhang, Feng Wei, Jing Zhang, Lanxiang Hao, Jie Jiang, Liansheng Dang, Dan Mei, ShanShan Fan, Yajin Yu, Ling Jiang
OBJECTIVE: To determine the relationship between papillary thyroid carcinoma and environmental exposure to bisphenol A (BPA) or 17-β estrogen (E2) by assessing the effects of these compounds on estrogen receptor expression and AKT/mTOR signaling. METHODS: The effects of low levels of BPA (1mM-10nM) and 17β-estradiol (E2, 0.1mM-1nM) on ER expression and cellular proliferation were determined in human thyroid papillary cancer BHP10-3 cells. Protein and mRNA levels of estrogen nuclear receptors (ERα/ERβ) and membrane receptors (GPR30) were determined by immunofluorescence assay, Western blotting, and RT-PCR, respectively, and proliferation was assessed by CCK-8 assay...
September 4, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28867067/corrigendum-to-prunetin-signals-via-g-protein-coupled-receptor-gpr30-stimulation-of-adenylyl-cyclase-and-camp-mediated-activation-of-mapk-signaling-induces-runx2-expression-in-osteoblasts-to-promote-bone-regeneration-j-nutr-biochem-2015-26-12-1491-501
#6
Kainat Khan, Subhashis Pal, Manisha Yadav, Rakesh Maurya, Arun Kumar Trivedi, Sabyasachi Sanyal, Naibedya Chattopadhyay
No abstract text is available yet for this article.
September 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28830788/zearalenone-and-alpha-zearalenol-inhibit-the-synthesis-and-secretion-of-pig-follicle-stimulating-hormone-via-the-non-classical-estrogen-membrane-receptor-gpr30
#7
Jing He, Chao Wei, Yueqin Li, Ying Liu, Yue Wang, Jirong Pan, Jiali Liu, Yingjie Wu, Sheng Cui
Zearalenone (ZEA) is one of the most popular endocrine-disrupting chemicals and is mainly produced by fungi of the genus Fusarium. The excessive intake of ZEA severely disrupts human and animal fertility by affecting the reproductive axis. However, most studies on the effects of ZEA and its metabolite α-zearalenol (α-ZOL) on reproductive systems have focused on gonads. Few studies have investigated the endocrine-disrupting effects of ZEA and α-ZOL on pituitary gonadotropins, including follicle-stimulating hormone (FSH) and luteinizing hormone (LH)...
August 19, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28811233/stimulation-of-ovarian-cell-proliferation-by-tetrabromobisphenol-a-but-not-tetrachlorobisphenol-a-through-g-protein-coupled-receptor-30
#8
Marta Hoffmann, Justyna Gogola, Małgorzata Kotula-Balak, Anna Ptak
Tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) are bisphenol A (BPA) analogs, where the phenolic moieties are substituted with halogens (Br or Cl). Previous studies indicate that BPA has significant proliferative effects on in vitro cultured epithelial ovarian cancer (EOC) cells. Considering this, we analyzed the effects of both TBBPA and TCBPA at 1, 10, and 50nM on ovarian cancer cell proliferation. The majority of malignant ovarian tumors are epithelial in origin, but approximately 10% are classified as ovarian sex cord tumors, with the most common type being granulosa cell tumors (GCTs)...
August 12, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28774890/mir-338-controls-bpa-triggered-pancreatic-islets-insulin-secretory-dysfunction-from-compensation-to-decompensation-by-targeting-pdx-1
#9
Jie Wei, Dongxiao Ding, Tao Wang, Qiong Liu, Yi Lin
Bisphenol A (BPA) can disrupt glucose homeostasis and impair pancreatic islet function; however, the mechanisms behind these effects are poorly understood. Male mice (4 wk old) were treated with BPA (50 or 500 μg/kg/day) for 8 wk. Whole-body glucose homeostasis, pancreatic islet morphology and function, and miR-338-mediated molecular signal transduction analyses were examined. We showed that BPA treatment led to a disruption of glucose tolerance and a compensatory increase of pancreatic islets insulin secretion and pancreatic and duodenal homeobox 1 (Pdx1) expression in mice...
August 3, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28736254/bisphenol-a-affects-trophoblast-invasion-by-inhibiting-cxcl8-expression-in-decidual-stromal-cells
#10
Xiaoqian Li, Yina Wang, Pu Wei, Dongyan Shi, Shuang Wen, Fengjiao Wu, Lixin Liu, Ninghe Ye, Hong Zhou
Bisphenol A (BPA), an environmental endocrine-disrupting organic chemical, has been positively associated with the rate of implantation failure of in vitro fertilization. However, the underlying mechanisms remain unclear. To reveal the impact and the underlying mechanism of BPA on the crosstalk between trophoblast and decidual stromal cells (DSCs), we determined whether BPA was able to affect trophoblast invasion in vitro. We found that BPA significantly inhibited CXCL8 expression in DSCs, which hindered trophoblast invasion, and activated the phosphorylation of ERK in DSCs...
July 20, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28709892/liuwei-dihuang-soft-capsules-attenuates-endothelial-cell-apoptosis-to-prevent-atherosclerosis-through-gpr30-mediated-regulation-in-ovariectomized-apoe-deficient-mice
#11
Yi Jing, Danfeng Cai, Qi Chen, Qingping Xiong, Tianhui Hu, Yuan Yao, Chao Lin, Xin Sun, Ying Lu, Xueyun Kong, Xiang Wu, Yu Li, Huimin Bian
ETHNOPHARMACOLOGICAL RELEVANCE: Liuwei Dihuang (LWDH), a classical traditional Chinese medicine prescription, has been widely used to prevent and to treat various diseases with symptoms of 'Kidney-Yin' deficiency syndrome for over 1000 years in China. It is commonly used to treat functional decline associated with senile disease and menopausal syndrome, especially memory decline, insomnia, diabetes and osteoporosis. Modern experimental pharmacological studies indicated that the mechanism of LWDH treatment of menopausal syndrome may be associated with enhanced estrogenic effects...
July 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28671018/gper-1-gpr30-a-novel-estrogen-receptor-sited-in-the-cell-membrane-therapeutic-coupling-to-breast-cancer
#12
REVIEW
Luis Molina, Carlos D Figueroa, Kanti D Bhoola, Pamela Ehrenfeld
Breast cancer is clinically classified as 'estrogen-positive' when at least 1% of cancer cells stain for the estrogen receptor alpha (ERα). However, recent research on both basic and clinical aspects of breast cancer suggests that GPER-1 (G protein-coupled estrogen receptor-1) may have an important role in breast cancer. Areas covered: This review provides a comprehensive and systematic literature search on GPER-1. We have focused on the role of GPER-1 in breast cancer and on resistance to endocrine therapy, an unsolved clinical issue still under discussion...
August 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/28636986/the-positivity-of-g-protein-coupled-receptor-30-gpr-30-an-alternative-estrogen-receptor-is-not-different-between-type-1-and-type-2-endometrial-cancer
#13
Jiayi Wan, Yongxiang Yin, Min Zhao, Fang Shen, Miaoxin Chen, Qi Chen
It is well-known that the clinical outcomes are different between type 1 (estrogen dependent) and type 2 (estrogen independent) endometrial cancer. Studies have suggested that the estrogen receptor (ER) is positively correlated with endometrial cancer survival, however we previously reported that there is no difference in the positivity of ER as well as sex hormone levels between subtypes of cancer. G-protein-coupled receptor-30 (GPR 30), an alternative estrogen receptor has been suggested to be negatively correlated with clinical outcomes of endometrial cancer...
June 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28619359/postpartum-estrogen-withdrawal-impairs-gabaergic-inhibition-and-ltd-induction-in-basolateral-amygdala-complex-via-down-regulation-of-gpr30
#14
Rong Yang, Baofeng Zhang, Tingting Chen, Suyun Zhang, Ling Chen
Postpartum estrogen (E2) withdrawal is known to be a particularly vulnerable time for depressive symptoms. In this study, ovariectomized (OVX) mice were treated with co-administration of estradiol benzoate and progesterone (E2/P4) followed by administration of E2 alone (E2) and a subsequent E2 withdrawal (EW) to mimic the hormonal changes during pregnancy and postpartum. The objective of this study was to investigate the influence of E2 withdrawal after hormone-simulated pregnancy on synaptic function and plasticity in basolateral amygdala complex (BLA)...
June 13, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28612709/potential-phytoestrogen-alternatives-exert-cardio-protective-mechanisms-via-estrogen-receptors
#15
Marthandam Asokan Shibu, Wei-Wen Kuo, Chia-Hua Kuo, Cecilia-Hsuan Day, Chia-Yao Shen, Li-Chin Chung, Chao-Hung Lai, Lung-Fa Pan, V Vijaya Padma, Chih-Yang Huang
The 17 beta-estradiol (E2) is a sex hormone that is most abundant and most active estrogen in premenopausal women. The importance of E2 in providing cardioprotection and reducing the occurrence of heart disease in women of reproductive age has been well recognized. There are three subtype of estrogen receptors (ERs), including ERα, ERβ and GPR30 have been identified and accumulating evidence reveal their roles on E2-mediated genomic and nongenomic pathway in cardiomyocytes against various cardiac insults...
June 2017: BioMedicine
https://www.readbyqxmd.com/read/28597596/new-roles-for-neuronal-estrogen-receptors
#16
REVIEW
C-L Lu, C Herndon
Estrogens encompass steroid hormones which display physiological roles not only in the female reproductive system but also in other organ systems of non-reproductive controls, including the peripheral and central nervous systems. Traditionally, estrogen signals in neurons through a "genomic pathway": binding to estrogen receptors (ERs) which then interact with nuclear estrogen response elements to initiate transcription. This effect is usually delayed at onset (within several hours to days) and prolonged in duration...
July 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28582470/estradiol-upregulates-voltage-gated-sodium-channel-1-7-in-trigeminal-ganglion-contributing-to-hyperalgesia-of-inflamed-tmj
#17
Rui-Yun Bi, Zhen Meng, Peng Zhang, Xue-Dong Wang, Yun Ding, Ye-Hua Gan
BACKGROUND: Temporomandibular disorders (TMDs) have the highest prevalence in women of reproductive age. The role of estrogen in TMDs and especially in TMDs related pain is not fully elucidated. Voltage-gated sodium channel 1.7 (Nav1.7) plays a prominent role in pain perception and Nav1.7 in trigeminal ganglion (TG) is involved in the hyperalgesia of inflamed Temporomandibular joint (TMJ). Whether estrogen could upregulate trigeminal ganglionic Nav1.7 expression to enhance hyperalgesia of inflamed TMJ remains to be explored...
2017: PloS One
https://www.readbyqxmd.com/read/28501695/expression-of-aromatase-and-estrogen-receptors-in-lumbar-motoneurons-of-mice
#18
Ying-Xiao Ji, Mei Zhao, Ya-Ling Liu, Li-Sha Chen, Peng-Li Hao, Can Sun
Estrogen exerts protective roles in amyotrophic lateral sclerosis (ALS). However, the expression of aromatase (ARO) and estrogen receptors (ERs) in the motoneurons of spinal cord, has not yet been elucidated. By immunohistochemistry, we found that ARO and ERs were present in the ventral horn of adult mice lumbar spinal cord, and colocalized with SMI-32, a motoneuron specific marker. Within motoneurons, we observed that ARO is detected primarily in the cytoplasm, with fewer ARO in the nucleus; ERα and ERβ mainly localized in the nucleus with less in the cytoplasm; while GPR30 is located in soma and processes...
July 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28472669/the-role-of-estrogen-g-protein-coupled-receptor-30-gpr30-and-sexual-experience-in-sexual-incentive-motivation-in-male-rats
#19
W R Hawley, C Battista, S R Divack, N B Morales Núñez
Male rats exhibit reductions in sexual motivation following systemic administration of drugs that inhibit the conversion of testosterone to estrogen, which indicates that estrogen signaling plays a role in male rat sexual motivation. Given that estrogen G-protein coupled receptor 30 (GPR30) is expressed in brain areas that are important for male sexual behaviors and endocrine function, the primary aim of the current study was to examine the role that GPR30 plays in sexual motivation in both sexually naïve and sexually experienced male rats...
May 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28468943/estradiol-activates-chloride-channels-via-estrogen-receptor-%C3%AE-in-the-cell-membranes-of-osteoblasts
#20
Zhiqin Deng, Shuang Peng, Yanfang Zheng, Xiaoya Yang, Haifeng Zhang, Qiuchan Tan, Xiechou Liang, Hong Gao, Yuan Li, Yanqing Huang, Linyan Zhu, Tim J C Jacob, Lixin Chen, Liwei Wang
Estrogen plays important roles in regulation of bone formation. Cl(-) channels in the ClC family are expressed in osteoblasts and are associated with bone physiology and pathology, but the relationship between Cl(-) channels and estrogen is not clear. In this study the action of estrogen on Cl(-) channels was investigated in the MC3T3-E1 osteoblast cell line. Our results show that 17β-estradiol could activate a current that reversed at a potential close to the Cl(-) equilibrium potential, with a sequence of anion selectivity of I(-) > Br(-) > Cl(-) > gluconate, and was inhibited by the Cl(-) channel blockers 5-nitro-2-(3-phenylpropylamino)-benzoate and 4,4'-diisothiocyano-2,2'-stilbene disulfonic acid...
August 1, 2017: American Journal of Physiology. Cell Physiology
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