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Fetal compromise

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https://www.readbyqxmd.com/read/27892860/microvascular-lesions-and-changes-in-cell-proliferation-and-death-and-cytokine-expression-in-the-placentas-of-mice-experimentally-infected-with-equid-herpesvirus-1
#1
C N Zanuzzi, M E Bravi, M R Scrochi, F Nishida, N A Fuentealba, M E Diessler, H G Sguazza, C I Muglia, E J Gimeno, E L Portiansky, C G Barbeito, C M Galosi
This study describes the changes observed in the placentas of mice experimentally infected with an abortigenic strain of EHV-1 at mid-pregnancy and euthanized at days 3 and 4 post-infection. We analyzed microscopic vascular alterations, cell proliferation and death by immunohistochemistry, and the expression of IFN-γ, TNF-α and the IL-10 by qPCR and flow cytometry. Infected mice showed slight respiratory signs and ruffled fur during the first two days post-infection. Virus isolation and DNA detection were positive only in the lungs of the infected mice...
September 14, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27871474/the-relationship-between-maternal-placental-growth-factor-levels-and-intrapartum-fetal-compromise
#2
Larissa N Bligh, Ristan M Greer, Sailesh Kumar
INTRODUCTION: Whilst some cases of intrapartum fetal compromise are the result of unpredictable catastrophic events, the majority arise from an unrecognised reduction in feto-placental reserve in otherwise healthy pregnancies. There is currently no reliable technique prior to labour that identifies the at-risk fetus. We aimed to investigate the relationship between maternal levels of serum placental growth factor (PlGF) and intrapartum fetal compromise in term pregnancies prior to labour...
December 2016: Placenta
https://www.readbyqxmd.com/read/27862265/mode-of-delivery-and-long-term-health-related-quality-of-life-outcomes-a-prospective-population-based-study
#3
Stavros Petrou, Sung Wook Kim, Penny McParland, Elaine M Boyle
BACKGROUND: Relatively little is known about the effects of mode of delivery on long-term health-related quality-of-life outcomes. Furthermore, no previous study has expressed these outcomes in preference-based (utility) metrics. METHODS: The study population comprised 2,161 mothers recruited from a prospective population-based study in the East Midlands of England encompassing live births and stillbirths between 32(+0) and 36(+6) weeks' gestation and a sample of term-born controls...
November 14, 2016: Birth
https://www.readbyqxmd.com/read/27842594/fetal-gender-and-gestational-age-differentially-affect-pcsk9-levels-in-intrauterine-growth-restriction
#4
Ulrich Pecks, Werner Rath, Nicolai Maass, Bartlomiej Berger, Imke Lueg, André Farrokh, Sabrina Farrokh, Christel Eckmann-Scholz
BACKGROUND: Maternal and fetal Low Density Lipoprotein-Cholesterol (LDL-C) concentrations are compromised in intrauterine growth restriction (IUGR). Generally, LDL-C catabolism is under control of PCSK9 by binding to the LDL-receptor leading to its degradation. Hence, we hypothesized a role for PCSK9 in the modulation of lipid metabolism and placental transport in IUGR. METHODS: 172 women, 70 IUGR and 102 controls were included in the study. Maternal and fetal serum PCSK9 levels and lipid profiles including LDL-C were measured...
November 14, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27831546/diurnal-variations-of-short-term-variation-and-the-impact-of-multiple-recordings-on-measurement-accuracy
#5
G Seliger, D Petroff, S Seeger, D Hoyer, M Tchirikov, U Schneider
OBJECTIVE: Short-term variation (STV) from computerized cardiotocogram heart rate analysis is a parameter that complements decision making, regarding the delivery of fetuses in several high-risk situations. Although studies on the effects of gestational age and fetal pathology are convincing, there is a lack of data exploring diurnal variation and the adequacy of a single measurement. STUDY DESIGN: In this prospective observational study, fetal STV was monitored with the AN24 fetal ECG monitor (Monica Healthcare) each hour for at least 10 h in total, beginning at different times...
November 10, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27816161/trauma-and-considerations-unique-to-pregnancy
#6
REVIEW
Christy Pearce, Stephanie R Martin
Trauma complicates 6% to 7% of all pregnancies and requires multidisciplinary education and training for both trauma and obstetric teams to achieve the best outcome. It is important to understand the mechanisms of certain adverse maternal and fetal/neonatal outcomes incurred as a result of trauma, as well as caveats to pregnancy physiology that make some injuries more likely and detection of maternal compromise more difficult. This article focuses on these caveats and how to incorporate these into ongoing trauma protocols and offers suggestions for the formation of obstetric trauma response team...
December 2016: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/27809298/meconium-exposure-and-autism-risk
#7
K M Miller, G Xing, C K Walker
OBJECTIVE: This study aims to determine whether fetal meconium passage is associated with autism. STUDY DESIGN: This retrospective birth cohort analysis of 9 945 896 children born in California 1991 to 2008 linked discharge diagnosis and procedure codes for prenatal stressors, meconium-stained amniotic fluid (MSAF) and meconium aspiration syndrome (MAS) with autism diagnoses for 47 277 children through 2012. We assessed the relative risk of autism by meconium status using logistic regression, adjusting for demographic and clinical features...
November 3, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27806661/intrapartum-intervention-rates-and-perinatal-outcomes-following-induction-of-labour-after-41%C3%A2-%C3%A2-0-weeks-compared-to-expectant-management
#8
Elaine Yuzhen Teo, Sailesh Kumar
OBJECTIVE: There is limited evidence regarding the incidence of intrapartum fetal compromise in women who are induced compared to those managed expectantly. The aim of this study was to investigate intrapartum and perinatal outcomes in women who were induced at >41 + 0 weeks compared to an expectantly managed cohort. METHODS: This was a retrospective cohort study of singleton, non anomalous pregnancies delivering between 41 + 0-43 + 0 weeks at the Mater Mothers' Hospital, Brisbane...
November 2, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27793395/assessment-of-progressive-pathophysiology-after-early-prenatal-diagnosis-of-the-ebstein-anomaly-or-tricuspid-valve-dysplasia
#9
Elif Seda Selamet Tierney, Doff B McElhinney, Lindsay R Freud, Wayne Tworetzky, Bettina F Cuneo, Maria C Escobar-Diaz, Catherine Ikemba, Brian T Kalish, Rukmini Komarlu, Stéphanie M Levasseur, Michael D Puchalski, Gary M Satou, Norman H Silverman, Anita J Moon-Grady
In fetuses with Ebstein anomaly or tricuspid valve dysplasia (EA/TVD), poor hemodynamic status is associated with worse neonatal outcome. It is not known whether EA/TVD fetuses with more favorable physiology earlier in gestation progress to more severe disease in the third trimester. We evaluated if echocardiographic indexes in EA/TVD fetuses presenting <24 weeks of gestation are reliable indicators of physiologic status later in pregnancy. This multicenter, retrospective study included 51 fetuses presenting at <24 weeks of gestation with EA/TVD and serial fetal echocardiograms ≥4 weeks apart...
September 29, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27762166/birth-weight-centiles-risk-of-intrapartum-compromise-and-adverse-perinatal-outcomes-in-term-infants
#10
Danielle Dowdall, Christopher Flatley, Sailesh Kumar
OBJECTIVE: The objective of this study is to evaluate the association between birth weight centiles and the risk of intrapartum compromise and adverse neonatal outcomes in term pregnancies. METHODS: Retrospective study of 32 468 term singleton births at a major tertiary maternity hospital in Australia. Data comprised gestation, mode, and indication for delivery and adverse perinatal outcomes. Fetal sex and gestational age-specific birth weight centiles were the main exposure variable...
October 20, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27760522/amniotic-fluid-embolism-as-a-cause-of-maternal-mortality-in-china-between-1996-and-2013-a-population-based-retrospective-study
#11
Yi Mu, Nolan McDonnell, Zhuoyang Li, Juan Liang, Yanping Wang, Jun Zhu, Elizabeth Sullivan
BACKGROUND: To analyse the maternal mortality ratio, demographic and pregnancy related details in women who suffered a fatal amniotic fluid embolism (AFE) in China. METHODS: A retrospective population based study using data collected as part of the National Maternal Mortality Surveillance System between 1996 and 2013. Data were collected onto a standardised form from women whose cause of death was listed as being secondary to AFE. RESULTS: Records were available for 640 deaths...
October 19, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27759021/protection-against-maternal-infection-associated-fetal-growth-restriction-proof-of-concept-with-a-microbial-derived-immunomodulator
#12
N M Scott, J F Lauzon-Joset, A C Jones, K T Mincham, N M Troy, J Leffler, M Serralha, S L Prescott, S A Robertson, C Pasquali, A Bosco, P G Holt, D H Strickland
Infection-associated inflammatory stress during pregnancy is the most common cause of fetal growth restriction and/or miscarriage. Treatment strategies for protection of at-risk mothers are limited to a narrow range of vaccines, which do not cover the bulk of the common pathogens most frequently encountered. Using mouse models, we demonstrate that oral treatment during pregnancy with a microbial-derived immunomodulator (OM85), currently used clinically for attenuation of infection-associated airway inflammatory symptoms in infants-adults, markedly reduces risk for fetal loss/growth restriction resulting from maternal challenge with bacterial lipopolysaccharide or influenza...
October 19, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27743975/preconceptional-and-maternal-obesity-epidemiology-and-health-consequences
#13
REVIEW
Lucilla Poston, Rishi Caleyachetty, Sven Cnattingius, Camila Corvalán, Ricardo Uauy, Sharron Herring, Matthew W Gillman
Obesity in women of reproductive age is increasing in prevelance worldwide. Obesity reduces fertility and increases time taken to conceive, and obesity-related comorbidities (such as type 2 diabetes and chronic hypertension) heighten the risk of adverse outcomes for mother and child if the woman becomes pregnant. Pregnant women who are obese are more likely to have early pregnancy loss, and have increased risk of congenital fetal malformations, delivery of large for gestational age infants, shoulder dystocia, spontaneous and medically indicated premature birth, and stillbirth...
December 2016: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/27720904/endogenous-dna-damage-leads-to-p53-independent-deficits-in-replicative-fitness-in-fetal-murine-fancd2-hematopoietic-stem-and-progenitor-cells
#14
Young Me Yoon, Kelsie J Storm, Ashley N Kamimae-Lanning, Natalya A Goloviznina, Peter Kurre
Our mechanistic understanding of Fanconi anemia (FA) pathway function in hematopoietic stem and progenitor cells (HSPCs) owes much to their role in experimentally induced DNA crosslink lesion repair. In bone marrow HSPCs, unresolved stress confers p53-dependent apoptosis and progressive cell attrition. The role of FA proteins during hematopoietic development, in the face of physiological replicative demand, remains elusive. Here, we reveal a fetal HSPC pool in Fancd2(-/-) mice with compromised clonogenicity and repopulation...
November 8, 2016: Stem Cell Reports
https://www.readbyqxmd.com/read/27707701/moderate-folic-acid-supplementation-and-mthfd1-synthetase-deficiency-in-mice-a-model-for-the-r653q-variant-result-in-embryonic-defects-and-abnormal-placental-development
#15
Karen E Christensen, Wenyang Hou, Renata H Bahous, Liyuan Deng, Olga V Malysheva, Erland Arning, Teodoro Bottiglieri, Marie A Caudill, Loydie A Jerome-Majewska, Rima Rozen
BACKGROUND: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase (MTHFD1) R653Q, may modulate the effects of elevated folic acid intake. OBJECTIVES: We investigated the effects of moderate folic acid supplementation on reproductive outcomes and assessed the potential interaction of the supplemented diet with MTHFD1-synthetase (Mthfd1S) deficiency in mice, which is a model for the R653Q variant...
October 5, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27689239/treatment-options-for-hypertension-in-pregnancy-and-puerperium
#16
Farah H Amro, Hind N Moussa, Olaide A Ashimi, Baha M Sibai
Hypertensive disorders have become increasingly prevalent and complicate an increasing number of pregnancies. Therefore it is essential that the medications used to treat these disorders be well understood. Furthermore the management is complicated by special consideration needed for the physiologic changes of pregnancy as well as the consideration for possible adverse fetal effects. Areas covered: We performed a review of the scientific literature of medications used to treat hypertensive disorders in pregnancy...
October 11, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27687377/a-randomized-trial-comparing-prophylactic-phenylephrine-and-ephedrine-infusion-during-spinal-anesthesia-for-emergency-cesarean-delivery-in-cases-of-acute-fetal-compromise
#17
Kajal Jain, Jeetinder Kaur Makkar, Siva Subramani Vp, Shalini Gander, Praveen Kumar
BACKGROUND: Previous evidence showed that use of phenylephrine was associated with higher umbilical artery pH (UA pH) than ephedrine after elective cesarean delivery (CD). However, the best choice of vasopressor and its effect on funic gases in cases of acute fetal compromise require additional studies. METHODS: Ninety parturients showing acute fetal compromise during intrapartum period and taken up for CD (category II) under spinal anesthesia were randomized to receive prophylactic infusion of ephedrine 2...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27684889/implementation-of-the-four-category-classification-of-cesarean-section-urgency-in-clinical-practice-a-prospective-study
#18
Francesco Maneschi, Desiree Biccirè, Giusi Santangelo, Seila Perrone, Alberto Scaini, Carmine Cosentino
PURPOSE: This study is aimed at investigating the clinical efficacy of the 4-category classification of urgent cesarean section. METHODS: Women giving birth from September 2012 to December 2014 were prospectively investigated. Urgency C-section categories were color-coded: red - maternal/fetal life threat; yellow - maternal/fetal compromise, not life-threatening; and green - early delivery necessary. Results were audited. RESULTS: A total of 4,754 women gave birth in the period considered, 1,313 (27...
September 30, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27646638/ep16-10-prelabour-fetal-cardiac-output-and-risk-of-intrapartum-fetal-compromise
#19
A A Alsolai, L Bligh, S Kumar
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27614269/physician-morality-and-perinatal-decisions
#20
Howard Minkoff, Katherine Zafra, Sabharwal Amrita, Tracey E Wilson, Peter Homel
OBJECTIVE: Given the same set of "facts" (e.g. fetal prognosis) different physicians may not give the same advice to patients. Studies have shown that people differ in how they prioritize moral domains, but how those domains influence counseling and management has not been assessed among obstetricians. Our objective was to see if, given the same set of facts, obstetricians' counseling would vary depending on their prioritization of moral domains. DESIGN: Obstetricians completed questionnaires that included validated scales of moral domains (e...
August 31, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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