keyword
https://read.qxmd.com/read/38381712/molecular-and-morphological-data-suggest-a-new-species-of-big-eared-bat-vespertilionidae-corynorhinus-endemic-to-northeastern-mexico
#1
JOURNAL ARTICLE
Issachar L López-Cuamatzi, Jorge Ortega, Sandra M Ospina-Garcés, Gerardo Zúñiga, M Cristina MacSwiney G
Corynorhinus mexicanus is an insectivorous bat endemic to Mexico that inhabits the high and humid regions of the Sierra Madre Oriental (SMO), the Trans-Mexican Volcanic Belt (TMVB), and the Sierra Madre Occidental (SMOC). A previous study suggested that C. mexicanus could be a cryptic species complex due to the genetic divergence observed between specimens from the TMVB and SMOC. The present study implemented phylogenetic, population genetics, and morphological analyses to evaluate the hypothesis that C. mexicanus is a species complex...
2024: PloS One
https://read.qxmd.com/read/38256071/the-abundant-distribution-and-duplication-of-sars-cov-2-in-the-cerebrum-and-lungs-promote-a-high-mortality-rate-in-transgenic-hace2-c57-mice
#2
JOURNAL ARTICLE
Heng Li, Xin Zhao, Shasha Peng, Yingyan Li, Jing Li, Huiwen Zheng, Yifan Zhang, Yurong Zhao, Yuan Tian, Jinling Yang, Yibin Wang, Xinglong Zhang, Longding Liu
Patients with COVID-19 have been reported to experience neurological complications, although the main cause of death in these patients was determined to be lung damage. Notably, SARS-CoV-2-induced pathological injuries in brains with a viral presence were also found in all fatal animal cases. Thus, an appropriate animal model that mimics severe infections in the lungs and brain needs to be developed. In this paper, we compared SARS-CoV-2 infection dynamics and pathological injuries between C57BL/6Smoc- Ace2em3(hACE2-flag-Wpre-pA)Smoc transgenic hACE2-C57 mice and Syrian hamsters...
January 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38231198/catalytic-activity-and-autoprocessing-of-murine-caspase-11-mediate-noncanonical-inflammasome-assembly-in-response-to-cytosolic-lps
#3
JOURNAL ARTICLE
Daniel C Akuma, Kimberly A Wodzanowski, Ronit Schwartz Wertman, Patrick M Exconde, Víctor R Vázquez Marrero, Chukwuma E Odunze, Daniel Grubaugh, Sunny Shin, Cornelius Taabazuing, Igor E Brodsky
Inflammatory caspases are cysteine protease zymogens whose activation following infection or cellular damage occurs within supramolecular organizing centers (SMOCs) known as inflammasomes. Inflammasomes recruit caspases to undergo proximity-induced autoprocessing into an enzymatically active form that cleaves downstream targets. Binding of bacterial LPS to its cytosolic sensor, caspase-11 (Casp11), promotes Casp11 aggregation within a high-molecular-weight complex known as the noncanonical inflammasome, where it is activated to cleave gasdermin D and induce pyroptosis...
January 17, 2024: ELife
https://read.qxmd.com/read/38023706/role-of-human-dural-fibroblasts-in-the-angiogenic-responses-of-human-endothelial-cells-an-in-vitro-dural-model-and-the-application-of-lab-on-a-chip-for-edas
#4
JOURNAL ARTICLE
Woo-Keun Kwon, Chang-Min Yoo, Jang Hun Kim, Tae-Won Kim, An-Gi Kim, Min-Ho Hwang, Hyuk Choi
Encephaloduroarteriosynangiosis (EDAS), an indirect anastomosis procedure, is widely accepted as a primary treatment for moyamoya disease (MMD) to improve collateral blood flow. During surgical intervention, dural fibroblasts (DuF) are thought to produce various proteins that create an angiogenic microenvironment. However, the biophysiological evidence supporting the angiogenic properties of this surgical technique has not been thoroughly elucidated. The purpose of these studies was to determine whether DuF releases pro-angiogenic factors and chemokines and promotes angiogenic properties in human endothelial cells (ECs) under IL-1β-mediated wound conditions, which are expected to occur during the process of neo-vascularization within the dura mater...
November 2023: Bioengineering & Translational Medicine
https://read.qxmd.com/read/37914531/self-assembly-and-cytocompatibility-of-amino-acid-conjugates-containing-a-novel-water-soluble-aromatic-protecting-group
#5
JOURNAL ARTICLE
Valeria Castelletto, Lucas de Mello, Emerson Rodrigo da Silva, Jani Seitsonen, Ian W Hamley
There has been considerable interest in peptides in which the Fmoc (9-fluorenylmethoxycarbonyl) protecting group is retained at the N-terminus, since this bulky aromatic group can drive self-assembly, and Fmoc-peptides are biocompatible and have applications in cell culture biomaterials. Recently, analogues of new amino acids with 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) protecting groups have been developed for water-based peptide synthesis. Here, we report on the self-assembly and biocompatibility of Smoc-Ala, Smoc-Phe and Smoc-Arg as examples of Smoc conjugates to aliphatic, aromatic, and charged amino acids, respectively...
November 1, 2023: Biomacromolecules
https://read.qxmd.com/read/37883681/a-novel-multi-ion-evaluation-scheme-to-determine-stable-chlorine-isotope-ratios-37-cl-35-cl-of-chlordecone-by-lc-qtof
#6
JOURNAL ARTICLE
Maria Prieto-Espinoza, Laure Malleret, Sylvain Ravier, Patrick Höhener
Organochlorinated pesticides are highly persistent organic pollutants having important adverse effects in the environment. To study their fate, compound-specific isotope analysis (CSIA) may be used to investigate their degradation pathways and mechanisms but is currently limited to 13 C isotope ratios. The assessment of 37 Cl isotope ratios from mass spectra is complicated by the large number of isotopologues of polychlorinated compounds. For method development, chlordecone (C10 Cl10 O2 H2 ; hydrate form), an organochlorine insecticide that led to severe contamination of soils and aquatic ecosystems of the French West Indies, was taken as a model analyte...
October 26, 2023: Journal of the American Society for Mass Spectrometry
https://read.qxmd.com/read/37673917/optogenetic-engineering-of-sting-signaling-allows-remote-immunomodulation-to-enhance-cancer-immunotherapy
#7
JOURNAL ARTICLE
Yaling Dou, Rui Chen, Siyao Liu, Yi-Tsang Lee, Ji Jing, Xiaoxuan Liu, Yuepeng Ke, Rui Wang, Yubin Zhou, Yun Huang
The cGAS-STING signaling pathway has emerged as a promising target for immunotherapy development. Here, we introduce a light-sensitive optogenetic device for control of the cGAS/STING signaling to conditionally modulate innate immunity, called 'light-inducible SMOC-like repeats' (LiSmore). We demonstrate that photo-activated LiSmore boosts dendritic cell (DC) maturation and antigen presentation with high spatiotemporal precision. This non-invasive approach photo-sensitizes cytotoxic T lymphocytes to engage tumor antigens, leading to a sustained antitumor immune response...
September 6, 2023: Nature Communications
https://read.qxmd.com/read/37590248/smoc-1-interacts-with-both-bmp-and-glypican-to-regulate-bmp-signaling-in-c-elegans
#8
JOURNAL ARTICLE
Melisa S DeGroot, Byron Williams, Timothy Y Chang, Maria L Maas Gamboa, Isabel M Larus, Garam Hong, J Christopher Fromme, Jun Liu
Secreted modular calcium-binding proteins (SMOCs) are conserved matricellular proteins found in organisms from Caenorhabditis elegans to humans. SMOC homologs characteristically contain 1 or 2 extracellular calcium (EC)-binding domain(s) and 1 or 2 thyroglobulin type-1 (TY) domain(s). SMOC proteins in Drosophila and Xenopus have been found to interact with cell surface heparan sulfate proteoglycans (HSPGs) to exert both positive and negative influences on the conserved bone morphogenetic protein (BMP) signaling pathway...
August 17, 2023: PLoS Biology
https://read.qxmd.com/read/37564644/what-are-nlrp3-asc-specks-an-experimental-progress-of-22-years-of-inflammasome-research
#9
REVIEW
Abhinit Nagar, Ravi Bharadwaj, Mohammad Omar Faruk Shaikh, Abhishek Roy
Speck assembly is the hallmark of NLRP3 inflammasome activation. The 1µm structure comprising of NLRP3 and ASC is the first observable phenotype of NLRP3 activation. While the common consensus is that the specks are the site of inflammasome activity, no direct experimental evidence exists to support this notion. In these 22 years, since the inflammasome discovery, several research studies have been published which directly or indirectly support or refute the idea of speck being the inflammasome. This review compiles the data from two decades of research to answer a long-standing question: "What are NLRP3-ASC specks?"...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37551443/composite-elastomers-with-on-demand-convertible-phase-separations-achieve-large-and-healable-electro-actuation
#10
JOURNAL ARTICLE
Jiali Tang, Zheqi Chen, Yiting Cai, Yang Gao, Jin He, Youhua Xiao, Jie Mao, Junjie Zhao, Xiang Gao, Tiefeng Li, Yingwu Luo
Phase separation has been widely exploited for fabricating structured functional materials. Generally, after being fabricated, the phase structure in a hybrid material system has been set at a specific length scale and remains unchanged during the lifespan of the material. Herein, we report a strategy to construct on-demand and reversible phase switches among homogenous, nano- and macro-phase separation states in a composite elastomer during its lifespan. We trigger the nanophase separation by super-saturating an elastomer matrix with a carefully selected small-molecule organic compound (SMOC)...
August 8, 2023: Materials Horizons
https://read.qxmd.com/read/37330196/construction-of-a-brain-specific-slc23a2-gene-knockout-mice-model
#11
JOURNAL ARTICLE
Bin Cao, Yong Xia, Zengxuan Cai, Ziyu Wang, Chao Tang, Yanhua Song
Vitamin C (VC) is a key antioxidant of the Central Nervous System (CNS) and SLC23A2 (SVCT2) is the only transporter that actively transports VC into the brain. While the existing animal models of VC deficiency are in the whole body, the essential role of VC in brain development remains elusive. In our study presented here, the CRISPR/Cas9 technology was applied for the construction of a C57BL/6J-SLC23A2 em1(flox)Smoc mouse model, which was crossed with the Glial fibrillary acidic protein-driven Cre Recombinase (GFAP-Cre) genotype mice to generate a conditional knockout model of SLC23A2(SVCT2) gene in mice brain (GFAP-Cre;SLC23A2 flox/flox) after generations of crossbreeding...
June 15, 2023: Neuroscience
https://read.qxmd.com/read/37322567/novel-amino-li-resin-for-water-based-solid-phase-peptide-synthesis
#12
JOURNAL ARTICLE
Christina Uth, Simon Englert, Olga Avrutina, Harald Kolmar, Sascha Knauer
We report the first application of a novel amino-Li resin to water-based solid-phase peptide synthesis (SPPS) applying the Smoc-protecting group approach. We demonstrated that it is a suitable support for the sustainable water-based alternative to a classical SPPS approach. The resin possesses good swelling properties in aqueous milieu, provides significant coupling sites, and may be applicable to the synthesis of difficult sequences and aggregation-prone peptides.
June 15, 2023: Journal of Peptide Science
https://read.qxmd.com/read/37295534/mulching-vs-organic-soil-amendment-effects-on-adsorption-desorption-of-herbicides
#13
JOURNAL ARTICLE
Marwa Douibi, Akhil Krishtammagari, María J Sánchez-Martín, M Sonia Rodríguez-Cruz, Jesús M Marín-Benito
Mulching and organic soil amendment are two agricultural practices that are being increasingly used to preserve soil from degradation, although they may modify the fate of herbicides when applied in soils subjected to these practices. This study has set out to compare the impact of both agricultural practices on the adsorption-desorption behaviour of the herbicides S-metolachlor (SMOC), foramsulfuron (FORAM), and thiencarbazone-methyl (TCM) involving winter wheat mulch residues at different stages of decomposition and particle size, and unamended soils or those amended with mulch...
June 7, 2023: Science of the Total Environment
https://read.qxmd.com/read/36982500/chemokine-receptors-ccr6-and-pd1-blocking-scfv-e27-enhances-anti-egfr-car-t-therapeutic-efficacy-in-a-preclinical-model-of-human-non-small-cell-lung-carcinoma
#14
JOURNAL ARTICLE
Jing Wang, Yanan Wang, Hanyu Pan, Lin Zhao, Xinyi Yang, Zhiming Liang, Xiaoting Shen, Jing Zhang, Jinlong Yang, Yuqi Zhu, Jingna Xun, Yue Liang, Qinru Lin, Huitong Liang, Min Li, Huanzhang Zhu
Chimeric antigen receptor (CAR)-T cells, a therapeutic agent for solid tumors, are not completely effective due to a lack of infiltration of T cells into the tumor site and immunity caused by Programmed Death Receptor 1(PD1). Here, an epidermal growth factor receptor (EGFR) CAR-T cell was engineered to express the chemokine receptor CCR6 and secrete PD1 blocking Single-chain antibody fragment (scFv) E27 to enhance their anti-tumor effects. The findings showed that CCR6 enhanced the migration of EGFR CAR-E27-CCR6 T cells in vitro by the Transwell migration assay...
March 12, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36803956/oncogenic-flt3-internal-tandem-duplication-activates-e2f1-to-regulate-purine-metabolism-in-acute-myeloid-leukaemia
#15
JOURNAL ARTICLE
Zi-Yao Ou, Ke Wang, Wen-Wen Shen, Ge Deng, Ya-Yun Xu, Long-Fei Wang, Zhuo-Yan Zai, Yi-An Ling, Tao Zhang, Xiao-Qing Peng, Fei-Hu Chen
Oncogene FLT3 internal tandem duplication (FLT3-ITD) mutation accounts for 30% of acute myeloid leukaemia (AML) cases and induces transformation. Previously, we found that E2F transcription factor 1 (E2F1) was involved in AML cell differentiation. Here, we reported that E2F1 expression was aberrantly upregulated in AML patients, especially in AML patients carrying FLT3-ITD. E2F1 knockdown inhibited cell proliferation and increased cell sensitivity to chemotherapy in cultured FLT3-ITD-positive AML cells. E2F1-depleted FLT3-ITD+ AML cells lost their malignancy as shown by the reduced leukaemia burden and prolonged survival in NOD-Prkdcscid Il2rgem1 /Smoc mice receiving xenografts...
February 17, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/36711863/-c-elegans-smoc-1-interacts-with-both-bmp-and-glypican-to-regulate-bmp-signaling
#16
Melisa S DeGroot, Byron Williams, Timothy Y Chang, Maria L Maas Gamboa, Isabel Larus, J Christopher Fromme, Jun Liu
Secreted modular calcium binding (SMOC) proteins are conserved matricellular proteins found in organisms from C. elegans to humans. SMOC homologs characteristically contain one or two extracellular calcium (EC) binding domain(s) and one or two thyroglobulin type-1 (TY) domain(s). SMOC proteins in Drosophila and Xenopus have been found to interact with cell surface heparan sulfate protein glycans (HSPGs) to exert both positive and negative influences on the conserved bone morphogenetic protein (BMP) signaling pathway...
January 8, 2023: bioRxiv
https://read.qxmd.com/read/36593260/sulfoquinovose-is-a-widespread-organosulfur-substrate-for-roseobacter-clade-bacteria-in-the-ocean
#17
JOURNAL ARTICLE
Le Liu, Xiaofeng Chen, Jianing Ye, Xiaoyi Ma, Yu Han, Yajie He, Kai Tang
Sulfoquinovose (SQ) is one of the most abundant organosulfur compounds in the biosphere, and its biosynthesis and degradation can represent an important contribution to the sulfur cycle. To data, in marine environments, the microorganisms capable of metabolising SQ have remained unidentified and the sources of SQ are still uncertain. Herein, the marine Roseobacter clade bacteria (RCB) Dinoroseobacter shibae DFL 12 and Roseobacter denitrificans OCh 114 were found to grow using SQ as the sole source of carbon and energy...
January 2, 2023: ISME Journal
https://read.qxmd.com/read/36439148/editorial-the-role-of-immune-cells-in-the-progression-of-autoimmune-diseases-affecting-the-cns
#18
EDITORIAL
Czeslawa Kowal, Jelka Pohar, Flora Zavala
No abstract text is available yet for this article.
2022: Frontiers in Immunology
https://read.qxmd.com/read/36231111/the-railmap-of-type-i-interferon-induction-subcellular-network-plan-and-how-viruses-can-change-tracks
#19
REVIEW
Laura Weber, Gabrielle Vieyres
The innate immune response constitutes the cell's first line of defense against viruses and culminates in the expression of type I interferon (IFN) and IFN-stimulated genes, inducing an antiviral state in infected and neighboring cells. Efficient signal transduction is a key factor for strong but controlled type I IFN expression and depends on the compartmentalization of different steps of the signaling cascade and dynamic events between the involved compartments or organelles. This compartmentalization of the innate immune players not only relies on their association with membranous organelles but also includes the formation of supramolecular organizing centers (SMOCs) and effector concentration by liquid-liquid phase separation...
October 6, 2022: Cells
https://read.qxmd.com/read/35979366/supramolecular-organizing-centers-at-the-interface-of-inflammation-and-neurodegeneration
#20
REVIEW
Petra Sušjan-Leite, Taja Železnik Ramuta, Elvira Boršić, Sara Orehek, Iva Hafner-Bratkovič
The pathogenesis of neurodegenerative diseases involves the accumulation of misfolded protein aggregates. These deposits are both directly toxic to neurons, invoking loss of cell connectivity and cell death, and recognized by innate sensors that upon activation release neurotoxic cytokines, chemokines, and various reactive species. This neuroinflammation is propagated through signaling cascades where activated sensors/receptors, adaptors, and effectors associate into multiprotein complexes known as supramolecular organizing centers (SMOCs)...
2022: Frontiers in Immunology
keyword
keyword
105973
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.