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https://www.readbyqxmd.com/read/27886258/a-holistic-approach-to-dissecting-sparc-family-protein-complexity-reveals-fstl-1-as-an-inhibitor-of-pancreatic-cancer-cell-growth
#1
Katrina Viloria, Amanda Munasinghe, Sharan Asher, Roberto Bogyere, Lucy Jones, Natasha J Hill
SPARC is a matricellular protein that is involved in both pancreatic cancer and diabetes. It belongs to a wider family of proteins that share structural and functional similarities. Relatively little is known about this extended family, but evidence of regulatory interactions suggests the importance of a holistic approach to their study. We show that Hevin, SPOCKs, and SMOCs are strongly expressed within islets, ducts, and blood vessels, suggesting important roles for these proteins in the normal pancreas, while FSTL-1 expression is localised to the stromal compartment reminiscent of SPARC...
November 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27643657/individual-and-joint-toxicity-of-the-herbicide-s-metolachlor-and-a-metabolite-deethylatrazine-on-aquatic-crustaceans-difference-between-ecological-groups
#2
C Maazouzi, C Coureau, C Piscart, M Saplairoles, N Baran, P Marmonier
We studied the individual and joint acute toxicity of S-metolachlor (SMOC) and deethylatrazine (DEA - a metabolite of atrazine) on different non-target freshwater crustaceans. We used animals from different ecological groups: two amphipods from surface running water (Gammarus pulex and Gammarus cf. orinos), an isopod from surface stagnant water (Asellus aquaticus) and an amphipod living in groundwater (Niphargus rhenorhodanensis). Organisms were exposed to different levels of SMOC and DEA, alone or in binary mixture...
December 2016: Chemosphere
https://www.readbyqxmd.com/read/27377471/compound-specific-isotope-analyses-to-assess-tce-biodegradation-in-a-fractured-dolomitic-aquifer
#3
Justin A Clark, Randy L Stotler, Shaun K Frape, Walter A Illman
The potential for trichloroethene (TCE) biodegradation in a fractured dolomite aquifer at a former chemical disposal site in Smithville, Ontario, Canada, is assessed using chemical analysis and TCE and cis-DCE compound-specific isotope analysis of carbon and chlorine collected over a 16-month period. Groundwater redox conditions change from suboxic to much more reducing environments within and around the plume, indicating that oxidation of organic contaminants and degradation products is occurring at the study site...
July 5, 2016: Ground Water
https://www.readbyqxmd.com/read/27131475/experimental-and-modeling-of-the-unsaturated-transports-of-s-metolachlor-and-its-metabolites-in-glaciofluvial-vadose-zone-solids
#4
Pauline Sidoli, Laurent Lassabatere, Rafael Angulo-Jaramillo, Nicole Baran
The transport of pesticides to groundwater is assumed to be impacted by flow processes and geochemical interactions occurring in the vadose zone. In this study, the transport of S-metolachlor (SMOC) and its two metabolites ESA-metolachlor (MESA) and OXA-metolachlor (MOXA) in vadose zone materials of a glaciofluvial aquifer is studied at laboratory scale. Column experiments are used to study the leaching of a conservative tracer (bromide) and SMOC, MESA and MOXA under unsaturated conditions in two lithofacies, a bimodal gravel (Gcm,b) and a sand (S-x)...
July 2016: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/27101391/smoc-binds-to-pro-egf-but-does-not-induce-erk-phosphorylation-via-the-egfr
#5
J Terrig Thomas, Lina Chhuy-Hy, Kristin R Andrykovich, Malcolm Moos
In an attempt to identify the cell-associated protein(s) through which SMOC (Secreted Modular Calcium binding protein) induces mitogen-activated protein kinase (MAPK) signaling, the epidermal growth factor receptor (EGFR) became a candidate. However, although in 32D/EGFR cells, the EGFR was phosphorylated in the presence of a commercially available human SMOC-1 (hSMOC-1), only minimal phosphorylation was observed in the presence of Xenopus SMOC-1 (XSMOC-1) or human SMOC-2. Analysis of the commercial hSMOC-1 product demonstrated the presence of pro-EGF as an impurity...
2016: PloS One
https://www.readbyqxmd.com/read/27080408/chemical-and-isotopic-constrains-on-the-origin-of-brine-and-saline-groundwater-in-hetao-plain-inner-mongolia
#6
Jun Liu, Zongyu Chen, Lijuan Wang, Yilong Zhang, Zhenghong Li, Jiaming Xu, Yurong Peng
The origin and evolution of brine and saline groundwater have always been a challenged work for geochemists and hydrogeologists. Chemical and isotopic data of brine and saline waters were used to trace the sources of salinity and therefore to understand the transport mechanisms of groundwater in Xishanzui, Inner Mongolia. Both Cl/Br (molar) versus Na/Br (molar) and Cl (meq/L) versus Na (meq/L) indicated that salinity was from halite dissolution or at least a significant impact by halite dissolution. The logarithmic plot of the concentration trends of Cl (mg/L) versus Br (mg/L) for the evaporation of seawater and the Qinghai Salt Lake showed that the terrestrial halite dissolution was the dominated contribution for the salinity of this brine...
August 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/26988127/refinement-of-atomic-models-in-high-resolution-em-reconstructions-using-flex-em-and-local-assessment
#7
Agnel Praveen Joseph, Sony Malhotra, Tom Burnley, Chris Wood, Daniel K Clare, Martyn Winn, Maya Topf
As the resolutions of Three Dimensional Electron Microscopic reconstructions of biological macromolecules are being improved, there is a need for better fitting and refinement methods at high resolutions and robust approaches for model assessment. Flex-EM/MODELLER has been used for flexible fitting of atomic models in intermediate-to-low resolution density maps of different biological systems. Here, we demonstrate the suitability of the method to successfully refine structures at higher resolutions (2.5-4.5Å) using both simulated and experimental data, including a newly processed map of Apo-GroEL...
May 1, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/26511517/supramolecular-organizing-centers-smocs-as-signaling-machines-in-innate-immune-activation
#8
REVIEW
Qi Qiao, Hao Wu
Innate immunity offers the first line of defense against infections and other types of danger such as tumorigenesis. Its discovery provides tremendous therapeutic opportunities for numerous human diseases. Delving into the structural basis of signal transduction by innate immune receptors, our lab has recently helped to establish the new paradigm in which innate immune receptors transduce ligand-binding signals through formation of higher-order assemblies containing intracellular adapters, signaling enzymes and their substrates...
November 2015: Science China. Life Sciences
https://www.readbyqxmd.com/read/26405796/improvement-of-analytical-method-for-chlorine-dual-inlet-isotope-ratio-mass-spectrometry-of-organochlorines
#9
Tetyana Gilevska, Natalija Ivdra, Magali Bonifacie, Hans-Hermann Richnow
RATIONALE: The development of compound-specific chlorine isotope analysis (Cl-CSIA) is hindered by the lack of international organochlorine reference materials with isotopic compositions expressed in the δ(37) Cl notation. Thus, a reliable off-line analytical method is needed, allowing direct comparison of the δ(37) Cl values of molecularly different organic compounds with that of ocean-water chloride, to refer measurement results to a Standard Mean Ocean Chloride (SMOC) scale. METHODS: The analytical method included sealed-tube combustion of organochlorines, precipitation and subsequent conversion of formed inorganic chlorides into methyl chloride (CH3 Cl) for the determination of δ(37) Cl values by Dual-Inlet Isotope Ratio Mass Spectrometry (DI-IRMS)...
July 30, 2015: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/25915847/induction-of-the-intestinal-stem-cell-signature-gene-smoc-2-is-required-for-l1-mediated-colon-cancer-progression
#10
A Shvab, G Haase, A Ben-Shmuel, N Gavert, T Brabletz, S Dedhar, A Ben-Ze'ev
Overactivation of Wnt-β-catenin signaling, including β-catenin-TCF target gene expression, is a hallmark of colorectal cancer (CRC) development. We identified the immunoglobulin family of cell-adhesion receptors member L1 as a β-catenin-TCF target gene preferentially expressed at the invasive edge of human CRC tissue. L1 can confer enhanced motility and liver metastasis when expressed in CRC cells. This ability of L1-mediated metastasis is exerted by a mechanism involving ezrin and the activation of NF-κB target genes...
February 4, 2016: Oncogene
https://www.readbyqxmd.com/read/25765161/measuring-success-in-obesity-prevention-a-synthesis-of-health-promotion-switzerland-s-long-term-monitoring-and-evaluation-strategy
#11
REVIEW
Günter Ackermann, Michael Kirschner, Lisa Guggenbühl, Bettina Abel, Axel Klohn, Thomas Mattig
AIMS: Since 2007, Health Promotion Switzerland has implemented a national priority program for a healthy body weight. This article provides insight into the methodological challenges and results of the program evaluation. METHODS: Evaluation of the long-term program required targeted monitoring and evaluation projects addressing different outcome levels. The evaluation was carried out according to the Swiss Model for Outcome Classification (SMOC), a model designed to classify the effects of health promotion and prevention efforts...
2015: Obesity Facts
https://www.readbyqxmd.com/read/25647449/development-and-validation-of-an-universal-interface-for-compound-specific-stable-isotope-analysis-of-chlorine-37cl-35cl-by-gc-high-temperature-conversion-htc-ms-irms
#12
Julian Renpenning, Kristina L Hitzfeld, Tetyana Gilevska, Ivonne Nijenhuis, Matthias Gehre, Hans-Hermann Richnow
A universal application of compound-specific isotope analysis of chlorine was thus far limited by the availability of suitable analysis techniques. In this study, gas chromatography in combination with a high-temperature conversion interface (GC-HTC), converting organic chlorine in the presence of H2 to gaseous HCl, was coupled to a dual-detection system, combining an ion trap mass spectrometer (MS) and isotope-ratio mass spectrometer (IRMS). The combination of the MS/IRMS detection enabled a detailed characterization, optimization, and online monitoring of the high-temperature conversion process via ion trap MS as well as a simultaneous chlorine isotope analysis by the IRMS...
March 3, 2015: Analytical Chemistry
https://www.readbyqxmd.com/read/25359439/smocs-supramolecular-organizing-centres-that-control-innate-immunity
#13
Jonathan C Kagan, Venkat Giri Magupalli, Hao Wu
The diverse receptor families of the innate immune system activate signal transduction pathways that are important for host defence, but common themes to explain the operation of these pathways remain undefined. In this Opinion article, we propose--on the basis of recent structural and cell biological studies--the concept of supramolecular organizing centres (SMOCs) as location-specific higher-order signalling complexes in which increased local concentrations of signalling components promote the intrinsically weak allosteric interactions that are required for enzyme activation...
December 2014: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/25303661/nature-and-decomposition-degree-of-cover-crops-influence-pesticide-sorption-quantification-and-modelling
#14
A Cassigneul, L Alletto, P Benoit, V Bergheaud, V Etiévant, V Dumény, A L Le Gac, D Chuette, C Rumpel, E Justes
This study quantifies and models the influence of the type and the degree of decomposition of cover crops (CC) on three pesticides sorption: epoxiconazole (EPX), S-metolachlor (SMOC) and glyphosate (GLY). Residues of four cover crop species were incubated for 0, 6, 28 or 56 d in controlled conditions. For each incubation time, adsorption of pesticides on CC residues was measured in batch experiments. Additionally, the biochemical and elemental composition (Van Soest fractionation, C:N, (13)C NMR spectroscopy) of CC was characterized...
January 2015: Chemosphere
https://www.readbyqxmd.com/read/25233368/persistent-organic-pollutants-pops-and-metals-in-primiparous-women-a-comparison-from-canada-and-mexico
#15
COMPARATIVE STUDY
Bryan Adlard, Karelyn Davis, Chun Lei Liang, Meredith S Curren, Sandra Rodríguez-Dozal, Horacio Riojas-Rodríguez, Mauricio Hernández-Ávila, Warren Foster, Larry Needham, Lee-Yang Wong, Jean-Philippe Weber, Leonora Marro, Tara Leech, Jay Van Oostdam
Under the North American Commission for Environmental Cooperation (CEC) and its Sound Management of Chemicals (SMOC) program, a tri-national human contaminant monitoring initiative was completed to provide baseline exposure information for several environmental contaminants in Canada, Mexico and the United States (U.S). Blood samples were collected from primiparous women in Canada and Mexico, and were analysed for a suite of environmental contaminants including polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene(p,p'-DDE),beta-hexachlorocyclohexane (β-HCH), mercury and lead...
December 1, 2014: Science of the Total Environment
https://www.readbyqxmd.com/read/24477970/moocs-and-smocs-changing-the-face-of-medical-education
#16
Neel Sharma, Iain Doherty, Darren Harbutt
No abstract text is available yet for this article.
December 2014: Perspectives on Medical Education
https://www.readbyqxmd.com/read/24472581/a-bifurcated-proteoglycan-binding-small-molecule-carrier-for-sirna-delivery
#17
Matt Gooding, Derick Adigbli, A W Edith Chan, Roberta J Melander, Alexander J MacRobert, David L Selwood
A wider application of siRNA- and miRNA- based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modeled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC.
July 2014: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/24055953/sorption-and-mineralization-of-s-metolachlor-and-its-ionic-metabolites-in-soils-and-vadose-zone-solids-consequences-on-groundwater-quality-in-an-alluvial-aquifer-ain-plain-france
#18
Nicole Baran, Laurence Gourcy
This study characterizes the transfer of S-metolachlor (SMOC) and its metabolites, metolachlor ethane sulfonic acid (MESA) and metolachlor oxanilic acid (MOXA) to the alluvial aquifer. Sorption and mineralization of SMOC and its two ionic metabolites were characterized for cultivated soils and solids from the vadose (unsaturated) zone in the Ain Plain (France). Under sterile soil conditions, the absence of mineralization confirms the importance of biotic processes in SMOC degradation. There is some adsorption and mineralization of the parent molecule and its metabolites in the unsaturated zone, though less than in soils...
November 2013: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/23437253/the-heparin-binding-activity-of-secreted-modular-calcium-binding-protein-1-smoc-1-modulates-its-cell-adhesion-properties
#19
Marina Klemenčič, Marko Novinec, Silke Maier, Ursula Hartmann, Brigita Lenarčič
Secreted modular calcium-binding proteins 1 and 2 (SMOC-1 and SMOC-1) are extracellular calcium- binding proteins belonging to the BM-40 family of proteins. In this work we have identified a highly basic region in the extracellular calcium-binding (EC) domain of the SMOC-1 similar to other known glycosaminoglycan-binding motifs. Size-exclusion chromatography shows that full length SMOC-1 as well as its C-terminal EC domain alone bind heparin and heparan sulfate, but not the related chondroitin sulfate or dermatan sulfate glycosaminoglycans...
2013: PloS One
https://www.readbyqxmd.com/read/23100137/ca-2-activated-ion-currents-triggered-by-ryanodine-receptor-mediated-ca-2-release-control-firing-of-inhibitory-neurons-in-the-prepositus-hypoglossi-nucleus
#20
Yasuhiko Saito, Yuchio Yanagawa
Spontaneous miniature outward currents (SMOCs) are known to exist in smooth muscles and peripheral neurons, and evidence for the presence of SMOCs in central neurons has been accumulating. SMOCs in central neurons are induced through Ca(2+)-activated K(+) (K(Ca)) channels, which are activated through Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum via ryanodine receptors (RyRs). Previously, we found that some neurons in the prepositus hypoglossi nucleus (PHN) showed spontaneous outward currents (SOCs)...
January 2013: Journal of Neurophysiology
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