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Sugar and inflammation and cancer

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https://www.readbyqxmd.com/read/29222421/the-transcriptomic-signature-of-disease-development-and-progression-of-nonalcoholic-fatty-liver-disease
#1
Sophie Cazanave, Alexei Podtelezhnikov, Kristian Jensen, Mulugeta Seneshaw, Divya P Kumar, Hae-Ki Min, Prasanna K Santhekadur, Bubu Banini, Adolfo Gabriele Mauro, Abdul M Oseini, Robert Vincent, Keith Q Tanis, Andrea L Webber, Liangsu Wang, Pierre Bedossa, Faridoddin Mirshahi, Arun J Sanyal
A longitudinal molecular model of the development and progression of nonalcoholic fatty liver disease (NAFLD) over time is lacking. We have recently validated a high fat/sugar water-induced animal (an isogenic strain of C57BL/6 J:129S1/SvImJ mice) model of NAFLD that closely mimics most aspects of human disease. The hepatic transcriptome of such mice with fatty liver (8 weeks), steatohepatitis with early fibrosis (16-24 weeks) and advanced fibrosis (52 weeks) after initiation of the diet was evaluated and compared to mice on chow diet...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29202699/comparison-of-lipopolysaccharides-composition-of-two-different-strains-of-helicobacter-pylori
#2
Kristy Leker, Ivonne Lozano-Pope, Keya Bandyopadhyay, Biswa P Choudhury, Marygorret Obonyo
BACKGROUND: Helicobacter pylori (H. pylori) is a Gram-negative, microaerophilic bacterium that is recognized as a major cause of chronic gastritis, peptic ulcers, and gastric cancer. Comparable to other Gram-negative bacteria, lipopolysaccharides (LPS) are an important cellular component of the outer membrane of H. pylori. The LPS of this organism plays a key role in its colonization and persistence in the stomach. In addition, H. pylori LPS modulates pathogen-induced host inflammatory responses resulting in chronic inflammation within the gastrointestinal tract...
December 4, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29113952/do-all-roads-lead-to-the-rome-the-glycation-perspective
#3
REVIEW
Saheem Ahmad, Firoz Akhter, Uzma Shahab, Zeeshan Rafi, Mohd Sajid Khan, Rabia Nabi, Mohd Salman Khan, Khurshid Ahmad, Jalaluddin Mohammad Ashraf, Moinuddin
Oxidative, carbonyl, and glycative stress have gained substantial attention recently for their alleged influence on cancer progression. Oxidative stress can trigger variable transcription factors, such as nuclear factor erythroid-2-related factor (Nrf2), nuclear factor kappa B (NF-κB), protein-53 (p-53), activating protein-1 (AP-1), hypoxia-inducible factor-1α (HIF-1α), β-catenin/Wnt and peroxisome proliferator-activated receptor-γ (PPAR-γ). Activated transcription factors can lead to approximately 500 different alterations in gene expression, and can alter expression patterns of inflammatory cytokines, growth factors, regulatory cell cycle molecules, and anti-inflammatory molecules...
November 4, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28874144/circadian-disruption-promotes-tumor-growth-by-anabolic-host-metabolism-experimental-evidence-in-a-rat-model
#4
Natalí N Guerrero-Vargas, Raful Navarro-Espíndola, Mara A Guzmán-Ruíz, María Del Carmen Basualdo, Estefania Espitia-Bautista, Ana López-Bago, Ricardo Lascurain, Cinthya Córdoba-Manilla, Ruud M Buijs, Carolina Escobar
BACKGROUND: Light at night creates a conflicting signal to the biological clock and disrupts circadian physiology. In rodents, light at night increases the risk to develop mood disorders, overweight, disrupted energy metabolism, immune dysfunction and cancer. We hypothesized that constant light (LL) in rats may facilitate tumor growth via disrupted metabolism and increased inflammatory response in the host, inducing a propitious microenvironment for tumor cells. METHODS: Male Wistar rats were exposed to LL or a regular light-dark cycle (LD) for 5 weeks...
September 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28745644/profiling-anti-neu5gc-igg-in-human-sera-with-a-sialoglycan-microarray-assay
#5
Shani Leviatan Ben-Arye, Hai Yu, Xi Chen, Vered Padler-Karavani
Cells are covered with a cloak of carbohydrate chains (glycans) that is commonly altered in cancer and that includes variations in sialic acid (Sia) expression. These are acidic sugars that have a 9-carbon backbone and that cap vertebrate glycans on cell surfaces. Two of the major Sia forms in mammals are N-acetylneuraminic acid (Neu5Ac) and its hydroxylated form, N-glycolylneuraminic acid (Neu5Gc). Humans cannot produce endogenous Neu5Gc due to the inactivation of the gene encoding cytidine 5'monophosphate-Neu5Ac (CMP-Neu5Ac) hydroxylase (CMAH)...
July 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28367220/lectins-interconnecting-proteins-with-biotechnological-pharmacological-and-therapeutic-applications
#6
REVIEW
Luana Cassandra Breitenbach Barroso Coelho, Priscila Marcelino Dos Santos Silva, Vera Lúcia de Menezes Lima, Emmanuel Viana Pontual, Patrícia Maria Guedes Paiva, Thiago Henrique Napoleão, Maria Tereza Dos Santos Correia
Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer. Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28334971/expanding-glycosaminoglycan-chemical-space-towards-the-creation-of-sulfated-analogs-novel-polymers-and-chimeric-constructs
#7
Rachel S Lane, Kalib St Ange, Behnam Zolghadr, Xinyue Liu, Christina Schäffer, Robert J Linhardt, Paul L DeAngelis
Glycosaminoglycans (GAGs) have therapeutic potential in areas ranging from angiogenesis, inflammation, hemostasis and cancer. GAG bioactivity is conferred by intrinsic structural features, such as disaccharide composition, glycosidic linkages and sulfation pattern. Unfortunately, the in vitro enzymatic synthesis of defined GAGs is quite restricted by a limited understanding of current GAG synthases and modifying enzymes. Our work provides insights into GAG-active enzymes through the creation of sulfated oligosaccharides, a new polysaccharide and chimeric polymers...
July 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28249935/an-adolescent-and-early-adulthood-dietary-pattern-associated-with-inflammation-and-the-incidence-of-breast-cancer
#8
Holly R Harris, Walter C Willett, Rita L Vaidya, Karin B Michels
Adolescence is a highly susceptible period for mammary carcinogenesis, but few prospective studies have examined the role of adolescent diet in breast cancer risk. Reduced rank regression has previously been used to identify a dietary pattern associated with markers of inflammation (C-reactive protein, IL6, and TNFα receptor 2). We investigated whether an adolescent and early adulthood inflammatory dietary pattern was associated with breast cancer among 45,204 women in the Nurses' Health Study II using reduced rank regression...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/27933449/clearing-the-fog-a-review-of-the-effects-of-dietary-omega-3-fatty-acids-and-added-sugars-on-chemotherapy-induced-cognitive-deficits
#9
REVIEW
Tonya S Orchard, Monica M Gaudier-Diaz, Kellie R Weinhold, A Courtney DeVries
Cancer treatments such as chemotherapy have been an important part of extending survival in women diagnosed with breast cancer. However, chemotherapy can cause potentially toxic side effects in the brain that impair memory, verbal fluency, and processing speed in up to 30% of women treated. Women report that post-chemotherapy cognitive deficits negatively impact quality of life and may last up to ten years after treatment. Mechanisms underlying these cognitive impairments are not fully understood, but emerging evidence suggests that chemotherapy induces structural changes in the brain, produces neuroinflammation, and reduces adult hippocampal neurogenesis...
February 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27853646/hepatocellular-carcinoma-is-accelerated-by-nash-involving-m2-macrophage-polarization-mediated-by-hif-1%C3%AE-induced-il-10
#10
Aditya Ambade, Abhishek Satishchandran, Banishree Saha, Benedek Gyongyosi, Patrick Lowe, Karen Kodys, Donna Catalano, Gyongyi Szabo
Obesity-related inflammation promotes cancer development. Tissue resident macrophages affect tumor progression and the tumor micro-environment favors polarization into alternatively activated macrophages (M2) that facilitate tumor invasiveness. Here, we dissected the role of western diet-induced NASH in inducing macrophage polarization in a carcinogen initiated model of hepatocellular carcinoma (HCC). Adult C57BL/6 male mice received diethyl nitrosamine (DEN) followed by 24 weeks of high fat-high cholesterol-high sugar diet (HF-HC-HSD)...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27784241/a-review-on-the-pharmacology-and-toxicology-of-steviol-glycosides-extracted-from-stevia-rebaudiana
#11
Amir Abbas Momtazi-Borojeni, Seyed-Alireza Esmaeili, Elham Abdollahi, Amirhossein Sahebkar
Stevia rebaudiana Bertoni is a sweet and nutrient-rich plant belonging to the Asteraceae family. Stevia leaves contain steviol glycosides including stevioside, rebaudioside (A to F), steviolbioside, and isosteviol, which are responsible for the plant's sweet taste, and have commercial value all over the world as a sugar substitute in foods, beverages and medicines. Among the various steviol glycosides, stevioside, rebaudioside A and rebaudioside C are the major metabolites and these compounds are on average 250-300 times sweeter than sucrose...
October 21, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27447047/high-sensitivity-and-low-toxicity-fucose-probe-for-glycan-imaging-and-biomarker-discovery
#12
Yasuhiko Kizuka, Sho Funayama, Hidehiko Shogomori, Miyako Nakano, Kazuki Nakajima, Ritsuko Oka, Shinobu Kitazume, Yoshiki Yamaguchi, Masahiro Sano, Hiroaki Korekane, Tsui-Ling Hsu, Hsiu-Yu Lee, Chi-Huey Wong, Naoyuki Taniguchi
Fucose, a terminal sugar in glycoconjugates, critically regulates various physiological and pathological phenomena, including cancer development and inflammation. However, there are currently no probes for efficient labeling and detection of this sugar. We chemically synthesized a novel series of alkynyl-fucose analogs as probe candidates and found that 7-alkynyl-fucose gave the highest labeling efficiency and low cytotoxicity. Among the fucose analogs, 7-alkynyl-fucose was the best substrate against all five fucosyltransferases examined...
July 21, 2016: Cell Chemical Biology
https://www.readbyqxmd.com/read/27347105/pioglitazone-does-not-increase-the-risk-of-type-ii-diabetes-in-patients-with-bladder-cancer-a-retrospective-study
#13
Youhong Dong, Anping Wang
The aim of the retrospective study was to analyze the effect of pioglitazone on the expression of tumor tissue inflammation factor interleukin (IL)-8, macrophage colony-stimulating factor (M-CSF) and vascular endothelial growth factor (VEGF) of type II diabetes in bladder cancer patients. In addition, whether there was a correlation between pioglitazone and the occurrence of male bladder cancer was also investigated. In total, 42 male cases diagnosed with type II diabetes secondary to bladder cancer were selected...
July 2016: Oncology Letters
https://www.readbyqxmd.com/read/27075026/sugared-biomaterial-binding-lectins-achievements-and-perspectives
#14
REVIEW
P Bojarová, V Křen
Lectins, a distinct group of glycan-binding proteins, play a prominent role in the immune system ranging from pathogen recognition and tuning of inflammation to cell adhesion or cellular signalling. The possibilities of their detailed study expanded along with the rapid development of biomaterials in the last decade. The immense knowledge of all aspects of glycan-lectin interactions both in vitro and in vivo may be efficiently used in bioimaging, targeted drug delivery, diagnostic and analytic biological methods...
July 19, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/26774083/glycative-stress-from-advanced-glycation-end-products-ages-and-dicarbonyls-an-emerging-biological-factor-in-cancer-onset-and-progression
#15
REVIEW
Jer-An Lin, Chi-Hao Wu, Chi-Cheng Lu, Shih-Min Hsia, Gow-Chin Yen
In recent years, glycative stress from exogenous or endogenous advanced glycation end products (AGEs) and highly reactive dicarbonyls has gained great attention for its putative effects on cancer development. AGEs are a group of compounds formed from the complex chemical reaction of reducing sugars with compounds containing an amino group. AGEs bind to and activate the receptor for AGEs (RAGE), which is a predominant modulator of inflammation-associated cancer, and AGEs induce reactive oxygen species that are an important regulator of the hallmarks of cancer...
August 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26729790/a-sucrose-enriched-diet-promotes-tumorigenesis-in-mammary-gland-in-part-through-the-12-lipoxygenase-pathway
#16
Yan Jiang, Yong Pan, Patrea R Rhea, Lin Tan, Mihai Gagea, Lorenzo Cohen, Susan M Fischer, Peiying Yang
Epidemiologic studies have shown that dietary sugar intake has a significant impact on the development of breast cancer. One proposed mechanism for how sugar impacts cancer development involves inflammation. In the current study, we investigated the impact of dietary sugar on mammary gland tumor development in multiple mouse models, along with mechanisms that may be involved. We found that sucrose intake in mice comparable with levels of Western diets led to increased tumor growth and metastasis, when compared with a nonsugar starch diet...
January 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/26614599/association-of-coffee-consumption-with-overall-and-cause-specific-mortality-in-a-large-us-prospective-cohort-study
#17
RANDOMIZED CONTROLLED TRIAL
Erikka Loftfield, Neal D Freedman, Barry I Graubard, Kristin A Guertin, Amanda Black, Wen-Yi Huang, Fatma M Shebl, Susan T Mayne, Rashmi Sinha
Concerns about high caffeine intake and coffee as a vehicle for added fat and sugar have raised questions about the net impact of coffee on health. Although inverse associations have been observed for overall mortality, data for cause-specific mortality are sparse. Additionally, few studies have considered exclusively decaffeinated coffee intake or use of coffee additives. Coffee intake was assessed at baseline by self-report in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Hazard ratios were estimated using Cox proportional hazards models...
December 15, 2015: American Journal of Epidemiology
https://www.readbyqxmd.com/read/26594225/nitroxide-pharmaceutical-development-for-age-related-degeneration-and-disease
#18
REVIEW
Jacob A Zarling, Vienna E Brunt, Anne K Vallerga, Weixing Li, Albert Tao, David A Zarling, Christopher T Minson
Nitroxide small molecule agents are in development as preventative or therapeutic pharmaceutical drugs for age-related macular degeneration (AMD) and cardiovascular disease, which are two major diseases of aging. These aging diseases are associated with patient genetics, smoking, diet, oxidative stress, and chronic inflammation. Nitroxide drugs preventing aging-, smoking-, high sugar or high fat diet-, or radiation- and other environmental-induced pathophysiological conditions in aging disease are reviewed...
2015: Frontiers in Genetics
https://www.readbyqxmd.com/read/26556271/symbiotic-human-gut-bacteria-with-variable-metabolic-priorities-for-host-mucosal-glycans
#19
Nicholas A Pudlo, Karthik Urs, Supriya Suresh Kumar, J Bruce German, David A Mills, Eric C Martens
UNLABELLED: Many symbiotic gut bacteria possess the ability to degrade multiple polysaccharides, thereby providing nutritional advantages to their hosts. Like microorganisms adapted to other complex nutrient environments, gut symbionts give different metabolic priorities to substrates present in mixtures. We investigated the responses of Bacteroides thetaiotaomicron, a common human intestinal bacterium that metabolizes more than a dozen different polysaccharides, including the O-linked glycans that are abundant in secreted mucin...
November 10, 2015: MBio
https://www.readbyqxmd.com/read/26551879/ethnopharmacological-uses-of-sempervivum-tectorum-l-in-southern-serbia-scientific-confirmation-for-the-use-against-otitis-linked-bacteria
#20
Dejan Stojković, Lillian Barros, Jovana Petrović, Jasmina Glamoclija, Celestino Santos-Buelga, Isabel C F R Ferreira, Marina Soković
ETHNOPHARMACOLOGICAL RELEVANCE: Sempervivum tectorum L. (Crassulaceae), known as houseleek, is used in traditional medicine in the treatment of ear inflammation. It can be spread as a pack on wounds, sores, burns, and abscesses and also on painful areas attacked by gout as a refrigerant and astringent. Drinking tea prepared from leaves of S. tectorum is recommended for ulcer treatment. The present study was designed to investigate ethopharmacological use of S. tectorum in the southern Serbia and to further scientifically justify and confirm effectiveness of the leaf juice used in ethnomedicine for ear inflammation, against otitis linked bacteria...
December 24, 2015: Journal of Ethnopharmacology
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