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Sugar and cancer

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https://www.readbyqxmd.com/read/28726641/a-plant-fungal-type-phosphoenolpyruvate-carboxykinase-located-in-the-parasite-mitochondrion-ensures-glucose-independent-survival-of-toxoplasma-gondii
#1
Richard Nitzsche, Özlem Günay-Esiyok, Maximilian Tischer, Vyacheslav Zagoriy, Nishith Gupta
Toxoplasma gondii is considered as one of the most successful intracellular pathogens, because it can reproduce in varied nutritional milieus, encountered in diverse host-cell types of essentially any warm-blooded organism. Our earlier work has demonstrated that the acute (tachyzoite) stage of T. gondii depends on cooperativity of glucose and glutamine catabolism to meet biosynthetic demands. Either of these two nutrients can sustain the parasite survival; however, what determines the metabolic plasticity has not been resolved yet...
July 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28718681/partial-substitution-of-glucose-with-xylitol-suppressed-the-glycolysis-and-selectively-inhibited-the-proliferation-of-oral-cancer-cells
#2
Dunyaporn Trachootham, Pimjai Chingsuwanrote, Penkhair Yoosadiang, Duangsamon Mekkriangkrai, Tanapat Ratchawong, Nicha Buraphacheep, Siripa Kijanukul, Sumrit Saekhow, Orawan Pongpitchayadej, Kittituch Vongvachvasin, Paknisa Sittikornpaiboon, Siriporn Tuntipopipat
Suitable diet for cancer survivors remains an unresolved challenge. Increased glucose utilization is a hallmark of various cancers. Therefore, alternative carbohydrate supplying normal tissue but retarding cancer growth is needed. This study investigated the effect of sugar alcohols on the proliferation of oral cancer cells compared to nontransformed cells and explored the mechanism. Six oral squamous cell carcinoma (CAL-27, FaDu, SCC4, SCC9, SCC15, and SCC25) and one nontransformed oral keratinocyte (OKF6/TERT2) lines were cultured in media containing 1 mg/ml glucose and 5...
July 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28704405/community-health-workers-for-non-communicable-diseases-prevention-and-control-in-developing-countries-evidence-and-implications
#3
Gursimer Jeet, J S Thakur, Shankar Prinja, Meenu Singh
BACKGROUND: National programs for non-communicable diseases (NCD) prevention and control in different low middle income countries have a strong community component. A community health worker (CHW) delivers NCD preventive services using informational as well as behavioural approaches. Community education and interpersonal communication on lifestyle modifications is imparted with focus on primordial prevention of NCDs and screening is conducted as part of early diagnosis and management...
2017: PloS One
https://www.readbyqxmd.com/read/28700660/cancer-selective-single-agent-chemoradiosensitising-gold-nanoparticles
#4
Sophie Grellet, Konstantina Tzelepi, Meike Roskamp, Phil Williams, Aquila Sharif, Richard Slade-Carter, Peter Goldie, Nicky Whilde, Małgorzata A Śmiałek, Nigel J Mason, Jon P Golding
Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations...
2017: PloS One
https://www.readbyqxmd.com/read/28693233/pre-operative-evaluation-of-circulating-kl-6-levels-as-a-biomarker-for-epithelial-ovarian-carcinoma-and-its-correlation-with-tumor-muc1-expression
#5
Sho Sato, Tomomi Kato, Kenji Abe, Tatsuya Hanaoka, Yuri Yano, Akira Kurosaki, Masanori Yasuda, Tetsuo Sekino, Keiichi Fujiwara, Kosei Hasegawa
Krebs von den Lungen-6 (KL-6), a mucinous sialylated sugar chain on human mucin-1 glycoprotein (MUC1), is a diagnostic marker for interstitial lung diseases. Furthermore, elevated serum KL-6 levels have been observed in certain malignant tumor types of epithelial origin. The expression of MUC1 has been observed in patients with epithelial ovarian cancer (EOC) and is considered a potential therapeutic target. In the present study, KL-6 serum levels were investigated in patients clinically suspected of having malignant ovarian tumors...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692034/mir-200b-inhibits-proliferation-and-metastasis-of-breast-cancer-by-targeting-fucosyltransferase-iv-and-%C3%AE-1-3-fucosylated-glycans
#6
Q Zheng, X Cui, D Zhang, Y Yang, X Yan, M Liu, B Niang, F Aziz, S Liu, Q Yan, J Liu
Aberrant protein fucosylation is associated with cancer malignancy. Fucosyltransferase IV (FUT4) is the key enzyme catalyzing the biosynthesis of α1,3-linkage fucosylated glycans carried by glycoproteins on the cell surface, such as the tumor-associated sugar antigen Lewis Y (LeY). An abnormal increase in the levels of FUT4 and LeY is observed in many cancers and correlated with cell proliferation and metastasis. Some microRNAs (miRNAs) are known to negatively regulate gene expression. FUT4 is an oncogenic glycogene, and thus it is important to identify the specific miRNA targeting FUT4...
July 10, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28688112/consumption-of-fruits-vegetables-and-fruit-juices-and-differentiated-thyroid-carcinoma-risk-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-study
#7
Raul Zamora-Ros, Virginie Béraud, Silvia Franceschi, Valerie Cayssials, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Elisabete Weiderpass, Kim Overvad, Anne Tjønneland, Anne Kirstine Eriksen, Fabrice Bonnet, Aurélie Affret, Verena Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Elisavet Valanou, Anna Karakatsani, Giovanna Masala, Sara Grioni, Maria Santucci de Magistris, Rosario Tumino, Fulvio Ricceri, Guri Skeie, Christine L Parr, Susana Merino, Elena Salamanca-Fernández, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Martin Almquist, Isabel Drake, Joakim Hennings, Maria Sandström, H Bas Bueno-de-Mesquita, Petra H Peeters, Kay-Thee Khaw, Nicholas J Wareham, Julie A Schmidt, Aurora Perez-Cornago, Dagfinn Aune, Elio Riboli, Nadia Slimani, Augustin Scalbert, Isabelle Romieu, Antonio Agudo, Sabina Rinaldi
Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000...
July 8, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28684356/sauromatum-guttatum-lectin-spectral-studies-lectin-carbohydrate-interaction-molecular-cloning-and-in-silico-analysis
#8
Kshema Thakur, Tarnjeet Kaur, Jatinder Singh, Gulam Rabbani, Rizwan H Khan, Rachna Hora, Manpreet Kaur
Non-immune carbohydrate binding proteins are broadly defined as lectins. Having been reported from all kingdoms of life, phytolectins are the most widely studied group of lectins. Sauromatum guttatum agglutinin (SGA) was isolated from the plant tubers and characterized for structural variations due to solvent perturbation using polarimetry, fluorescence and light scattering. For the β-sheet rich SGA, a pH and temperature induced molten globule like intermediate was identified. In isothermal titration microcalorimetry, SGA demonstrated cooperative binding to a complex glycoprotein in enthalpically driven mechanism...
July 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28670495/bitterness-in-sugar-o-glcnacylation-aggravates-pre-b-acute-lymphocytic-leukemia-through-glycolysis-via-the-pi3k-akt-c-myc-pathway
#9
Bing Zhang, Panpan Zhou, Xue Li, Qing Shi, Dong Li, Xiuli Ju
Abnormal cellular energetics has emerged as a hallmark of cancer cells. Deregulating aerobic glycolysis can alter multiple metabolic and signaling pathways in cancer cells, and trigger unlimited growth and proliferation. Accumulating evidence suggests that elevated levels of protein modification with β-N-acetylglucosamine (O-GlcNAcylation) along with dysregulation of O-GlcNAc transferase (OGT) and/or O-GlcNAcase (OGA) levels may act as a nutrient sensor in cancer cells. However, the underlying mechanism of O-GlcNAcylation and the relationship between O-GlcNAcylation and glycolysis are largely unknown in pre-B acute lymphocytic leukemia (pre-B-ALL)...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28666157/application-of-ft-ir-spectroscopy-on-breast-cancer-serum-analysis
#10
Fatemeh Elmi, Afshin Fayyaz Movaghar, Maryam Mitra Elmi, Heshmatollah Alinezhad, Novin Nikbakhsh
Breast cancer is regarded as the most malignant tumor among women throughout the world. Therefore, early detection and proper diagnostic methods have been known to help save women's lives. Fourier Transform Infrared (FT-IR) spectroscopy, coupled with PCA-LDA analysis, is a new technique to investigate the characteristics of serum in breast cancer. In this study, 43 breast cancer and 43 healthy serum samples were collected, and the FT-IR spectra were recorded for each one. Then, PCA analysis and linear discriminant analysis (LDA) were used to analyze the spectral data...
June 20, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28665423/an-integrated-biorefinery-concept-for-conversion-of-sugar-beet-pulp-into-value-added-chemicals-and-pharmaceutical-intermediates
#11
Max Cárdenas-Fernández, Maria Bawn, Charlotte Hamley-Bennett, Penumathsa K V Bharat, Fabiana Subrizi, Nurashikin Suhaili, David P Ward, Sarah Bourdin, Paul A Dalby, Helen C Hailes, Peter Hewitson, Svetlana Ignatova, Cleo Kontoravdi, David J Leak, Nilay Shah, Tom D Sheppard, John M Ward, Gary J Lye
Over 8 million tonnes of sugar beet are grown annually in the UK. Sugar beet pulp (SBP) is the main by-product of sugar beet processing which is currently dried and sold as a low value animal feed. SBP is a rich source of carbohydrates, mainly in the form of cellulose and pectin, including d-glucose (Glu), l-arabinose (Ara) and d-galacturonic acid (GalAc). This work describes the technical feasibility of an integrated biorefinery concept for the fractionation of SBP and conversion of these monosaccharides into value-added products...
June 30, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28660452/bamboo-shoots-as-a-nutritive-boon-for-northeast-india-an-overview
#12
Anusriti Basumatary, Sushil Kumar Middha, Talambedu Usha, Amit Kumar Basumatary, Birendra Kumar Brahma, Arvind Kumar Goyal
With about 136 species, India is one among the richest countries in bamboo resources that help mankind in more than 1500 diverse ways. Although the utilization of juvenile shoots of bamboo in tribal diet of Northeast India is a very old observable fact, its numerous health benefits and potentiality remains uncharted. Apart from being delicious, the bamboo shoots are also rich in minerals and nutrient components such as carbohydrates, proteins, fiber and are low in fat and sugar which could be helpful in mitigating the problem of malnutrition...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28653068/targeting-heparin-and-heparan-sulfate-protein-interactions
#13
Ryan J Weiss, Jeffrey D Esko, Yitzhak Tor
Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are made up of alternating dissacharide sequences of sulfated uronic acid and amino sugars. Unlike heparin, which is only found in mast cells, heparan sulfate is ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These negatively-charged glycans play essential roles in important cellular functions such as cell growth, adhesion, angiogenesis, and blood coagulation. These biomolecules are also involved in pathophysiological conditions such as pathogen infection and human disease...
July 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28636761/molecular-tools-for-facilitative-carbohydrate-transporters
#14
Marina Tanasova, Joseph R Fedie
Facilitative carbohydrate transporters - Gluts - have received a wide attention over decades due to their essential role in the nutrient uptake and links with various metabolic disorders, including diabetes, obesity, and cancer. Endeavors into understanding mechanisms of Glut-mediated nutrient uptake have resulted in the multidisciplinary research field, branching protein chemistry, chemical biology, organic synthesis, crystallography, and biomolecular modeling. Gluts became attractive targets for cancer research and medicinal chemistry, leading to the development of new approaches to cancer diagnostics and providing avenues for cancer-targeting therapeutics...
June 21, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28633895/synthesis-of-meon-neoglycosides-of-digoxigenin-with-6-deoxy-and-2-6-dideoxy-d-glucose-derivatives-and-their-anticancer-activity
#15
Dong-Dong Wang, Xiao-San Li, Yu-Zhou Bao, Jie Liu, Xiao-Kun Zhang, Xin-Sheng Yao, Xue-Long Sun, Jin-Shan Tang
Cardiac glycosides show anticancer activities and their deoxy-sugar chains are vital for their anticancer effects. In order to study the structure-activity relationship (SAR) of cardiac glycosides toward cancers and get more potent anticancer agents, a series of MeON-neoglycosides of digoxigenin was synthesized and evaluated. First, ten 6-deoxy- and 2,6-dideoxy-d-glucopyranosyl donors were synthesized starting from methyl α-d-glucopyranoside and 2-deoxy-d-glucose. Meanwhile, the digoxigenin was obtained by acidic hydrolysis of commercially available digoxin as glycosyl acceptor...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28616398/new-photodynamic-therapy-with-next-generation-photosensitizers
#16
REVIEW
Hiromi Kataoka, Hirotada Nishie, Noriyuki Hayashi, Mamoru Tanaka, Akihiro Nomoto, Shigenobu Yano, Takashi Joh
Photodynamic therapy (PDT) is a non-invasive antitumor treatment that uses the combination of a photosensitizer, tissue oxygen, and visible light irradiation to produce cytotoxic reactive oxygen species, predominantly singlet oxygen. Currently, first-generation PDT using porfimer sodium with an excimer dye laser, and second-generation PDT using talaporfin sodium PDT with a semiconductor laser are approved by health insurance for use in Japan. However, the cancer cell specificity and selectivity of these treatments are inadequate...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28613111/synthesis-and-anticancer-activity-of-new-indolyl-pyrazolyl-1-3-4-oxadiazole-thioglycosides-and-acyclic-nucleoside-analogs
#17
Wael A El-Sayed, Walaa I El-Sofany, Hoda A R Hussein, Nahed M Fathi
New [(Indolyl)pyrazolyl]-1,3,4-oxadiazole compounds and their derived thioglycosides as well as the corresponding sugar hydrazones were synthesized. The acyclo C-nucleoside analogs of the oxadiazoline base system were also prepared by reaction of acid hydrazides with aldehydo sugars followed by one pot process encompassing acetylation and cyclization of the synthesized hydrazones. The anticancer activity of the newly synthesized compounds was studied against colorectal carcinoma (HCT116), breast adenocarcinoma (MCF7) and prostate cancer (PC3) human tumor cell lines and a number of compounds showed moderate to high activities...
June 14, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28609132/antioxidant-and-anticancer-properties-of-berries
#18
Bincy Baby, Priya Antony, Ranjit Vijayan
The enduring relationship between dietary patterns and human health has led us to investigate the bioactive components present in fruits and vegetables for a very long time. Berries, notably the popular ones such as strawberry, raspberry, blueberry, blackberry and the Indian gooseberry, are among the best known dietary sources due to the presence of a wide range of bioactive nutritive components. Bioactive components in berries include phenolic compounds, flavonoids and tannins apart from vitamins, minerals, sugars and fibers...
June 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28606705/improving-food-choices-and-nutrient-adequacy-in-adolescents-young-adults-with-developmental-disabilities
#19
Regina M Subach
BACKGROUND: Persons with intellectual and developmental disabilities (DD) have higher incidences of overweight and obesity than the general population and are currently underserved in health promotion programs. Restricted diets due to sensory sensitivity and physiological difference are often followed by persons with DD resulting in nutrient inadequacies, which may contribute to overweight and obesity. Closing the gap of healthcare disparities for persons with DD must start by increasing awareness of factors causing overweight and obesity, and development of strategies and programs to reduce incidences of overweight and obesity for persons with DD...
June 1, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28600360/are-self-reported-unhealthy-food-choices-associated-with-an-increased-risk-of-breast-cancer-prospective-cohort-study-using-the-british-food-standards-agency-nutrient-profiling-system
#20
Mélanie Deschasaux, Chantal Julia, Emmanuelle Kesse-Guyot, Lucie Lécuyer, Solia Adriouch, Caroline Méjean, Pauline Ducrot, Sandrine Péneau, Paule Latino-Martel, Léopold K Fezeu, Philippine Fassier, Serge Hercberg, Mathilde Touvier
OBJECTIVES: French authorities are considering the implementation of a simplified nutrition labelling system on food products to help consumers make healthier food choices. One of the most documented candidates (Five-Colour Nutrition Label/Nutri-score) is based on the British Food Standards Agency Nutrient Profiling System (FSA-NPS), a score calculated for each food/beverage using the 100 g amount of energy, sugar, saturated fatty acid, sodium, fibres, proteins, and fruits and vegetables...
June 8, 2017: BMJ Open
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