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https://www.readbyqxmd.com/read/28636761/molecular-tools-for-facilitative-carbohydrate-transporters
#1
Marina Tanasova, Joseph R Fedie
Facilitative carbohydrate transporters - Gluts - have received a wide attention over decades due to their essential role in the nutrient uptake and links with various metabolic disorders, including diabetes, obesity, and cancer. Endeavors into understanding mechanisms of Glut-mediated nutrient uptake have resulted in the multidisciplinary research field, branching protein chemistry, chemical biology, organic synthesis, crystallography, and biomolecular modeling. Gluts became attractive targets for cancer research and medicinal chemistry, leading to the development of new approaches to cancer diagnostics and providing avenues for cancer-targeting therapeutics...
June 21, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28633895/synthesis-of-meon-neoglycosides-of-digoxigenin-with-6-deoxy-and-2-6-dideoxy-d-glucose-derivatives-and-their-anticancer-activity
#2
Dong-Dong Wang, Xiao-San Li, Yu-Zhou Bao, Jie Liu, Xiao-Kun Zhang, Xin-Sheng Yao, Xue-Long Sun, Jin-Shan Tang
Cardiac glycosides show anticancer activities and their deoxy-sugar chains are vital for their anticancer effects. In order to study the structure-activity relationship (SAR) of cardiac glycosides toward cancers and get more potent anticancer agents, a series of MeON-neoglycosides of digoxigenin was synthesized and evaluated. First, ten 6-deoxy- and 2,6-dideoxy-d-glucopyranosyl donors were synthesized starting from methyl α-d-glucopyranoside and 2-deoxy-d-glucose. Meanwhile, the digoxigenin was obtained by acidic hydrolysis of commercially available digoxin as glycosyl acceptor...
June 3, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28616398/new-photodynamic-therapy-with-next-generation-photosensitizers
#3
REVIEW
Hiromi Kataoka, Hirotada Nishie, Noriyuki Hayashi, Mamoru Tanaka, Akihiro Nomoto, Shigenobu Yano, Takashi Joh
Photodynamic therapy (PDT) is a non-invasive antitumor treatment that uses the combination of a photosensitizer, tissue oxygen, and visible light irradiation to produce cytotoxic reactive oxygen species, predominantly singlet oxygen. Currently, first-generation PDT using porfimer sodium with an excimer dye laser, and second-generation PDT using talaporfin sodium PDT with a semiconductor laser are approved by health insurance for use in Japan. However, the cancer cell specificity and selectivity of these treatments are inadequate...
April 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28613111/synthesis-and-anticancer-activity-of-new-indolyl-pyrazolyl-1-3-4-oxadiazole-thioglycosides-and-acyclic-nucleoside-analogs
#4
Wael A El-Sayed, Walaa I El-Sofany, Hoda A R Hussein, Nahed M Fathi
New [(Indolyl)pyrazolyl]-1,3,4-oxadiazole compounds and their derived thioglycosides as well as the corresponding sugar hydrazones were synthesized. The acyclo C-nucleoside analogs of the oxadiazoline base system were also prepared by reaction of acid hydrazides with aldehydo sugars followed by one pot process encompassing acetylation and cyclization of the synthesized hydrazones. The anticancer activity of the newly synthesized compounds was studied against colorectal carcinoma (HCT116), breast adenocarcinoma (MCF7) and prostate cancer (PC3) human tumor cell lines and a number of compounds showed moderate to high activities...
June 14, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28609132/antioxidant-and-anticancer-properties-of-berries
#5
Bincy Baby, Priya Antony, Ranjit Vijayan
The enduring relationship between dietary patterns and human health has led us to investigate the bioactive components present in fruits and vegetables for a very long time. Berries, notably the popular ones such as strawberry, raspberry, blueberry, blackberry and the Indian gooseberry, are among the best known dietary sources due to the presence of a wide range of bioactive nutritive components. Bioactive components in berries include phenolic compounds, flavonoids and tannins apart from vitamins, minerals, sugars and fibers...
June 13, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28606705/improving-food-choices-and-nutrient-adequacy-in-adolescents-young-adults-with-developmental-disabilities
#6
Regina M Subach
BACKGROUND: Persons with intellectual and developmental disabilities (DD) have higher incidences of overweight and obesity than the general population and are currently underserved in health promotion programs. Restricted diets due to sensory sensitivity and physiological difference are often followed by persons with DD resulting in nutrient inadequacies, which may contribute to overweight and obesity. Closing the gap of healthcare disparities for persons with DD must start by increasing awareness of factors causing overweight and obesity, and development of strategies and programs to reduce incidences of overweight and obesity for persons with DD...
June 1, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28600360/are-self-reported-unhealthy-food-choices-associated-with-an-increased-risk-of-breast-cancer-prospective-cohort-study-using-the-british-food-standards-agency-nutrient-profiling-system
#7
Mélanie Deschasaux, Chantal Julia, Emmanuelle Kesse-Guyot, Lucie Lécuyer, Solia Adriouch, Caroline Méjean, Pauline Ducrot, Sandrine Péneau, Paule Latino-Martel, Léopold K Fezeu, Philippine Fassier, Serge Hercberg, Mathilde Touvier
OBJECTIVES: French authorities are considering the implementation of a simplified nutrition labelling system on food products to help consumers make healthier food choices. One of the most documented candidates (Five-Colour Nutrition Label/Nutri-score) is based on the British Food Standards Agency Nutrient Profiling System (FSA-NPS), a score calculated for each food/beverage using the 100 g amount of energy, sugar, saturated fatty acid, sodium, fibres, proteins, and fruits and vegetables...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28598369/plant-lectins-targeting-o-glycans-at-the-cell-surface-as-tools-for-cancer-diagnosis-prognosis-and-therapy
#8
REVIEW
Guillaume Poiroux, Annick Barre, Els J M van Damme, Hervé Benoist, Pierre Rougé
Aberrant O-glycans expressed at the surface of cancer cells consist of membrane-tethered glycoproteins (T and Tn antigens) and glycolipids (Lewis a, Lewis x and Forssman antigens). All of these O-glycans have been identified as glyco-markers of interest for the diagnosis and the prognosis of cancer diseases. These epitopes are specifically detected using T/Tn-specific lectins isolated from various plants such as jacalin from Artocarpus integrifola, and fungi such as the Agaricus bisporus lectin. These lectins accommodate T/Tn antigens at the monosaccharide-binding site; residues located in the surrounding extended binding-site of the lectins often participate in the binding of more extended epitopes...
June 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28590090/motile-hepatocellular-carcinoma-cells-preferentially-secret-sugar-metabolism-regulatory-proteins-via-exosomes
#9
Jing Zhang, Shaohua Lu, Ye Zhou, Kun Meng, Zhipeng Chen, Yizhi Cui, Yunfeng Shi, Qing-Yu He, Tong Wang
Exosomes are deliverers of critically functional proteins, capable of transforming target cells in numerous cancers, including hepatocellular carcinoma (HCC). We hypothesize that the motility of HCC cells can be featured by comparative proteome of exosomes. Hence, we performed the super-SILAC-based MS analysis on the exosomes secreted by three human HCC cell lines, including the non-motile Hep3B cell, and the motile 97H and LM3 cells. Over 1400 exosomal proteins were confidently quantified in each MS analysis with highly biological reproducibility...
June 7, 2017: Proteomics
https://www.readbyqxmd.com/read/28585445/lactose-esters-synthesis-and-biotechnological-applications
#10
Jakub Staroń, Janusz M Dąbrowski, Ewelina Cichoń, Maciej Guzik
Biodegradable nonionic sugar esters-based surfactants have been gaining more and more attention in recent years due to their chemical plasticity that enables the various applications of these molecules. In this review, various synthesis methods and biotechnological implications of lactose esters (LEs) uses are considered. Several chemical and enzymatic approaches are described for the synthesis of LEs, together with their applications, i.e. function in detergents formulation and as additives that not only stabilize food products but also protect food from undesired microbial contamination...
June 6, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28581703/anion-exchange-chromatography-coupled-to-high-resolution-mass-spectrometry-a-powerful-tool-for-merging-targeted-and-non-targeted-metabolomics
#11
Michaela Schwaiger, Evelyn Rampler, Gerrit Hermann, Walter Miklos, Walter Berger, Gunda Koellensperger
In this work, simultaneous targeted metabolic profiling by isotope dilution and non-targeted fingerprinting is proposed for cancer cell studies. The novel streamlined metabolomics workflow was established using anion-exchange chromatography (IC) coupled to high resolution mass spectrometry (MS). The separation time of strong anion-exchange (2 mm column, flow rate 380 µL min(-1), injection volume 5 µL) could be decreased to 25 min for a target list comprising organic acids, sugars, sugar phosphates and nucleotides...
June 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28576066/designing-of-macroporous-magnetic-bioscaffold-based-on-functionalized-methacrylate-network-covered-by-hydroxyapatites-and-doped-with-nano-mgfe2o4-for-potential-cancer-hyperthermia-therapy
#12
Łukasz John, Mateusz Janeta, Sławomir Szafert
In this paper, we report on synthesis and characterization of three-dimensional biocomposite based on a polymerized 3-(trimethoxysilyl)propyl methacrylate/ethylene glycol dimethacrylate (pTMSPMA/pEGDMA) framework. The resulting composite was doped with Ca(2+) and PO4(3-) or decorated by hydroxyapatite (HA) and carbonate hydroxyapatite (CHA) to aid potential bone fixation and the in vitro bioactivity was evaluated. During the construction of the macroporous scaffold, the size and shape of pores were modified depending on the type of porogens which was applied (commercially available sugar, NaCl, or NH4Cl)...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28554813/impact-of-exopolysaccharides-epss-of-lactobacillus-gasseri-strains-isolated-from-human-vagina-on-cervical-tumor-cells-hela
#13
Tolga Sungur, Belma Aslim, Cagtay Karaaslan, Busra Aktas
Lactobacilli, commonly used as probiotics, have been shown to maintain vaginal health and contribute to host microbiota interaction. Exopolysaccharides (EPSs) produced by lactobacillus have been found to have an important role in probiotic activity; however, there is limited knowledge concerning their impact on cervical cancer and urogenital health. The objective of this study is to investigate and compare EPSs of L. gasseri strains (G10 and H15), isolated from a healthy human vagina, for their capability to inhibit cervical cancer cell (HeLa) growth and modulate immune response...
May 26, 2017: Anaerobe
https://www.readbyqxmd.com/read/28545086/cancer-cell-spheroids-are-a-better-screen-for-the-photodynamic-efficiency-of-glycosylated-photosensitizers
#14
Patrícia M R Pereira, Naxhije Berisha, N V S Dinesh K Bhupathiraju, Rosa Fernandes, João P C Tomé, Charles Michael Drain
Photodynamic Therapy (PDT) relies on the use of non-toxic photosensitizers that are locally and selectively activated by light to induce cell death or apoptosis through reactive oxygen species generation. The conjugation of porphyrinoids with sugars that target cancer is increasingly viewed as an effective way to increase the selectivity of PDT. To date, in vitro PDT efficacy is mostly screened using two-dimensional monolayer cultures. Compared to monolayer cultures, three-dimensional spheroid cultures have unique spatial distributions of nutrients, metabolites, oxygen and signalling molecules; therefore better mimic in vivo conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28540940/modelling-charge-transfer-processes-in-c-2-tetrahydrofuran-collision-for-ion-induced-radiation-damage-in-dna-building-blocks
#15
Ewa Erdmann, Marie-Christine Bacchus-Montabonel, Marta Łabuda
Investigations of collision-induced processes involving carbon ions and molecules of biological interest, in particular DNA building blocks, are crucial to model the effect of radiation on cells in order to improve medical treatments for cancer therapy. Using carbon ions appears to be one of the most efficient ways to increase biological effectiveness to damage cancerous cells by irradiating deep-seated tumors. Therefore, interest in accurate calculations to understand fundamental processes occurring in ion-molecule collision systems has been growing recently...
May 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28531327/interstrand-cross-links-arising-from-strand-breaks-at-true-abasic-sites-in-duplex-dna
#16
Zhiyu Yang, Nathan E Price, Kevin M Johnson, Yinsheng Wang, Kent S Gates
Interstrand cross-links are exceptionally bioactive DNA lesions. Endogenous generation of interstrand cross-links in genomic DNA may contribute to aging, neurodegeneration, and cancer. Abasic (Ap) sites are common lesions in genomic DNA that readily undergo spontaneous and amine-catalyzed strand cleavage reactions that generate a 2,3-didehydro-2,3-dideoxyribose sugar remnant (3'ddR5p) at the 3'-terminus of the strand break. Interestingly, this strand scission process leaves an electrophilic α,β-unsaturated aldehyde residue embedded within the resulting nicked duplex...
May 22, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28526362/using-secondary-24-hour-dietary-recall-data-to-estimate-daily-dietary-factor-intake-from-the-flashe-study-dietary-screener
#17
Teresa M Smith, Eric E Calloway, Courtney A Pinard, Erin Hennessy, April Y Oh, Linda C Nebeling, Amy L Yaroch
INTRODUCTION: The National Cancer Institute's 2014 Family Life, Activity, Sun, Health, and Eating Study utilized a 27-item Dietary Screener tailored to adolescent eating patterns that assessed the frequency of intake of several foods and beverages in parent-adolescent dyads. This study estimated intake of fruits and vegetables (FVs), dairy, added sugars, and whole grains for screener respondents using existing, nationally representative, 24-hour dietary recall data. METHODS: Dietary Screener items were converted from frequency responses to daily intake...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28526132/old-and-novel-functions-of-caspase-2
#18
M A Miles, T Kitevska-Ilioski, C J Hawkins
Although caspase-2 is a highly conserved protease that has received a lot of research attention, consensus about its roles and the molecular mechanisms that underpin them has been elusive. Recent improvements to our understanding of the activities of caspase-2 have been facilitated by the development and refinement of techniques allowing identification of cellular processes instigated by this caspase. Following DNA damage, caspase-2 can be activated in a molecular complex called the "PIDDosome"; however, other stimuli provoke caspase-2-dependent activities that do not appear to involve this complex...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28511796/attenuation-of-deregulated-mir-369-3p-expression-sensitizes-non-small-cell-lung-cancer-cells-to-cisplatin-via-modulation-of-the-nucleotide-sugar-transporter-slc35f5
#19
Guang-Jun Hao, Yan-Hui Ding, Hui Wen, Xiao-Feng Li, Wei Zhang, Hu-Yan Su, Dong-Mei Liu, Nian-Lin Xie
Deregulation of the microRNAs (miRNAs), a cluster of important posttranscriptional regulators, has been frequently associated with lung cancer (LCa). However, the emerging mechanism for how miRNAs is linked causally in the development of LCa chemoresistance is poorly understood. Herein, we established for the time the up-regulation of miR-369-3p in cisplatin (DDP)-resistant nonsmall cell lung cancer (NSCLC) tissues and cells. Its deregulation was found to be correlated to the magnitude of malignancy in well-characterized LCa cells...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28511371/study-of-serum-total-psa-and-free-psa-as-an-oncological-marker-in-breast-tumour
#20
Elteza Tahjiba Jahir, Runi Devi, Bibhuti Bhushan Borthakur
INTRODUCTION: Breast Cancer (BC) cases are rising alarmingly all over the world and India is not an exception. This rising trend is due to an increased age at first child birth, decreased breast feeding, and the changing lifestyle mostly in urban India. With the advent of more sensitive methodologies and research works in this field, it has been suggested that Prostate Specific Antigen (PSA) plays an important role in the pathogenesis of breast cancer besides other established tumour markers...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
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