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Intrauterine death

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https://www.readbyqxmd.com/read/28219933/akt-signalling-as-a-mediator-of-cardiac-adaptation-to-low-birth-weight
#1
Kimberley Cw Wang, Kimberley J Botting, Song Zhang, Caroline McMillen, Doug A Brooks, Janna L Morrison
Intrauterine insults, such as poor nutrition and placental insufficiency, can alter cardiomyocyte development and this can have significant long-term implications for heart health. Consequently, epidemiological studies have shown that low birth weight babies have an increased risk of death from cardiovascular disease in adult life. In addition, intrauterine growth restriction can result in increased left ventricular hypertrophy, which is the strongest predictor for poor health outcomes in cardiac patients. The mechanisms responsible for these associations are not clear, but a suboptimal intrauterine environment can program alternative expression of genes such as cardiac IGF-2/H19, IGF-2R and AT1R through either an increase or decrease in DNA methylation or histone acetylation at specific loci...
February 20, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28207498/an-analysis-of-variations-of-indications-and-maternal-fetal-prognosis-for-caesarean-section-in-a-tertiary-hospital-of-beijing-a-population-based-retrospective-cohort-study
#2
Yajun Liu, Xin Wang, Liying Zou, Yan Ruan, Weiyuan Zhang
In recent decades, we have observed a remarkable increase in the rate of caesarean section (CS) in both developed and developing countries, especially in China. According to the World Health Organization (WHO) systematic review, if the increase in CS rate was between 10% and 15%, the maternal and neonatal mortality was decreased. However, above this level, increasing the rate of CS is no longer associated with reduced mortality. To date, no consensus has been reached on the main factors driving the cesarean epidemic...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28202111/-mortality-rate-and-cause-of-death-in-hospitalized-neonates-an-analysis-of-480-cases
#3
Feng-Dan Xu, Xiang-Yong Kong, Zhi-Chun Feng
OBJECTIVE: To investigate the mortality rate and the cause of death of hospitalized neonates. METHODS: The clinical data of 480 neonates who died between January 2008 and December 2014 were collected. The mortality rates of neonates with different gestational ages, birth weights, sexes, and ages in days were analyzed. The abnormal perinatal factors, cause of death, and death grade were summarized. RESULTS: Among the 41 910 hospitalized neonates, 480 (1...
February 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28178055/pulmonary-hypertension-in-pregnancy-a-report-of-49-cases-at-four-tertiary-north-american-sites
#4
Marie-Louise Meng, Ruth Landau, Olof Viktorsdottir, Jennifer Banayan, Tamila Grant, Brian Bateman, Richard Smiley, Elena Reitman
OBJECTIVE: To identify whether pregnancy outcomes vary by etiology and severity of pulmonary hypertension and whether contemporary therapies influence outcomes. METHODS: A retrospective review of medical records at four academic institutions was conducted to identify pregnant women with pulmonary hypertension (2001-2015). International Classification of Diseases, 9th Revision codes for pulmonary hypertension and pregnancy were used to identify potential participants...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28177551/the-significance-of-a-prenatal-diagnosis-of-right-aortic-arch
#5
Anna Wójtowicz, Maria Respondek-Liberska, Maciej Słodki, Paulina Kordjalik, Joanna Płużańska, Anna Knafel, Hubert Huras
OBJECTIVES: To analyze a population of fetuses with prenatally diagnosed right aortic arch (RAA). METHODS: Retrospective study of fetuses with RAA diagnosed prenatally between 2011 and 2015 in 2 referral centers. RESULTS: RAA was found in 4.4% (46/1036) of fetuses with cardiovascular abnormalities (CVA). As an isolated anomaly, RAA was present in 30.4% of cases; in 32.6%, other CVA were detected; in 23.9%, CVA and extracardiac anomalies; and in 13...
February 8, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28166593/impact-of-rare-bleeding-disorders-during-pregnancy-on-maternal-and-fetal-outcomes-review-of-29-pregnancies-at-a-single-center
#6
Gokcen Orgul, Fatih Aktoz, M Sinan Beksac
Objective This study aims to give information about the relationship between different types of factor deficiencies and maternal/obstetric outcomes. Methods We retrospectively reviewed the medical records of eight women with factor deficiency disorders. The demographic and clinical features of the patients after their last pregnancies were registered retrospectively. Results There were 29 pregnancies among the 8 patients. The spontaneous abortion rate was relatively high in two patients with factor XIII deficiency (80% and 57...
February 6, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28165177/intrauterine-death-rate-in-gastroschisis-following-the-introduction-of-an-antenatal-surveillance-program-retrospective-observational-study
#7
Helen Perry, Costa Healy, Diana Wellesley, Nigel J Hall, Melanie Drewett, David M Burge, David T Howe
AIM: To investigate whether an antenatal surveillance protocol including ultrasound and cardiotocograph monitoring reduces intrauterine death (IUD) in cases of gastroschisis. Secondary outcomes included neonatal death rate, mode of delivery and rate of intervention before planned time of delivery. METHODS: This was a retrospective observational study of all women with antenatally diagnosed gastroschisis who were managed according to the surveillance program between 2002 and 2015 in a tertiary fetal medicine and pediatric surgical center covering the Wessex region of England...
February 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28162192/-the-454th-case-a-29-week-pregnant-woman-with-abdominal-pain-hyperlipemia-and-multiorgan-dysfunction
#8
D Wu, J Xu, J M Peng, L K Ma, S Chen, X G Li, T P Zhang, J M Qian
A 32 year-old woman in the third trimester of pregnancy was admitted for severe acute pancreatitis due to hypertriglyceridemia. During hospitalization she developed multiorgan dysfunction, infected pancreatic necrosis, abdominal compartment syndrome and intrauterine fetal death. She was successfully treated by multidisciplinary team including department of emergency medicine, ICU, gastroenterology, obstetrics, endocrinology, ultrasonography, radiology, infectious disease, nutrition and surgery.
February 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28159120/women-s-experiences-of-stillbirth-in-somaliland-a-phenomenological-description
#9
Hodan Mohamoud Osman, Jama Ali Egal, Jonah Kiruja, Fatumo Osman, Ulrika Byrskog, Kerstin Erlandsson
BACKGROUND: Low- and middle-income countries in Africa have the highest rates of stillbirths in the world today: as such, the stories of the grief of these women who have had a stillbirth in these settings need to be told and the silence on stillbirth needs to be broken. In an attempt to fill this gap, the aim of this study was to describe the experiences of Muslim Somali mothers who have lost their babies at birth. METHOD: Qualitative interviews with ten Somali women one to six months after they experienced a stillbirth...
March 2017: Sexual & Reproductive Healthcare: Official Journal of the Swedish Association of Midwives
https://www.readbyqxmd.com/read/28152557/perinatal-outcome-of-placental-massive-perivillous-fibrin-deposition-a-case-control-study
#10
Louise Devisme, Claire Chauvière, Hélène Franquet-Ansart, Anastasia Chudzinski, Morgane Stichelbout, Véronique Houfflin-Debarge, Damien Subtil
OBJECTIVE: To describe the obstetric outcomes associated with massive perivillous fibrin deposition (MFD) compared with a control series and to determine if outcome differs according to the extent of fibrin deposition. METHOD: Retrospective case-control study based on placentas analyzed over a consecutive 12-years period. MFD was considered severe if it extended over more than 50% of the placenta and moderate between 25 and 50%. RESULTS: During the study period, MFD was observed on 71 placentas, 39 severe and 32 moderate...
February 2, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28150444/the-influence-of-chorionicity-and-gestational-age-at-single-fetal-loss-on-the-risk-of-preterm-birth-in-twin-pregnancies-analysis-of-the-stork-multiple-pregnancy-cohort
#11
Francesco D'Antonio, Basky Thilaganathan, Tiran Dias, Asma Khalil
BACKGROUND: Single intrauterine death (sIUD) in twin pregnancies is associated with a significant risk of co-twin demise and preterm birth (PTB), especially in monochorionic (MC) twins. However, it is yet to be established whether the gestational age at loss may influence the pregnancy outcome. The aim of this study was to explore the risk of PTB according to the gestational age at the diagnosis of sIUD. METHODS: A cohort study of all twin pregnancies from a large regional network of 9 hospitals over a ten-year period...
February 2, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28149327/in-utero-exposure-to-maternal-smoking-is-associated-with-dna-methylation-alterations-and-reduced-neuronal-content-in-the-developing-fetal-brain
#12
Zac Chatterton, Brigham J Hartley, Man-Ho Seok, Natalia Mendelev, Sean Chen, Maria Milekic, Gorazd Rosoklija, Aleksandar Stankov, Iskra Trencevsja-Ivanovska, Kristen Brennand, Yongchao Ge, Andrew J Dwork, Fatemeh Haghighi
BACKGROUND: Intrauterine exposure to maternal smoking is linked to impaired executive function and behavioral problems in the offspring. Maternal smoking is associated with reduced fetal brain growth and smaller volume of cortical gray matter in childhood, indicating that prenatal exposure to tobacco may impact cortical development and manifest as behavioral problems. Cellular development is mediated by changes in epigenetic modifications such as DNA methylation, which can be affected by exposure to tobacco...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28143885/does-first-trimester-screening-modify-the-natural-history-of-congenital-heart-disease-%C3%A2-analysis-of-outcome-of-regional-cardiac-screening-at-two-different-time-periods
#13
Hana Jicinska, Pavel Vlasin, Michal Jicinsky, Ilga Grochova, Viktor Tomek, Julia Volaufova, Jan Skovranek, Jan Marek
BACKGROUND: -The study analyzed the impact of first trimester screening on the spectrum of congenital heart defects (CHD) later in pregnancy, and on the outcome of fetuses and children born alive with CHD. METHODS: -The spectrum of CHD, associated comorbidities and outcome of fetuses either diagnosed with CHD in the first trimester (Group I, 127 fetuses), or only in the second trimester screening (Group II, 344 fetuses), were analyzed retrospectively between 2007 and 2013...
January 31, 2017: Circulation
https://www.readbyqxmd.com/read/28141944/a-case-report-of-intrauterine-foetal-death-subsequent-to-chorioamniotic-membrane-separation-after-foetal-intervention
#14
Masaharu Murata, Keisuke Ishii, Yuka Sato, Jun Sasahara, Shusaku Hayashi, Nobuaki Mitsuda
No abstract text is available yet for this article.
January 31, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28139506/reproductive-outcome-of-transcervical-uterine-incision-in-unicornuate-uterus
#15
En-Lan Xia, Tin-Chiu Li, Sze-Ngar Sylvia Choi, Qiao-Yun Zhou
BACKGROUND: The pregnancy outcome of the unicornuate uterus is associated with an increased risk of miscarriage, cervical incompetence, and a number of obstetric complications. However, at present, there is no accepted treatment method for women with unicornuate uterus, other than expectant measures. The aim of this study was to evaluate the reproductive outcome of transcervical uterine incision (TCUI) in patients with unicornuate uterus. METHODS: Thirty-three patients with unicornuate uterus presented to our tertiary center for infertility or miscarriage...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28137987/diagnostic-performance-of-placental-growth-factor-in-women-with-suspected-preeclampsia-attending-antenatal-facilities-in-maputo-mozambique
#16
U Vivian Ukah, Francisco Mbofana, Beatriz Manriquez Rocha, Osvaldo Loquiha, Chishamiso Mudenyanga, Momade Usta, Marilena Urso, Sharla Drebit, Laura A Magee, Peter von Dadelszen
In well-resourced settings, reduced circulating maternal-free placental growth factor (PlGF) aids in either predicting or confirming the diagnosis of preeclampsia, fetal growth restriction, stillbirth, preterm birth, and delivery within 14 days of testing when preeclampsia is suspected. This blinded, prospective cohort study of maternal plasma PlGF in women with suspected preeclampsia was conducted in antenatal clinics in Maputo, Mozambique. The primary outcome was the clinic-to-delivery interval. Other outcomes included: confirmed diagnosis of preeclampsia, transfer to higher care, mode of delivery, intrauterine fetal death, preterm birth, and low birth weight...
March 2017: Hypertension
https://www.readbyqxmd.com/read/28128088/gestational-pityriasis-rosea-suggestions-for-approaching-affected-pregnant-women
#17
Alexandra Monastirli, Efstathia Pasmatzi, George Badavanis, Dionysios Tsambaos
Dear Editor, Pityriasis rosea is a common, acute, and self-limiting dermatosis, which is associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7 (1). It predominantly affects individuals of both sexes in their second or third decade of life and is clinically characterized by the occurrence of an initial erythematosquamous plaque followed by the appearance of disseminated similar but smaller lesions one or two weeks later. Several patients develop systemic symptoms such as nausea, anorexia, malaise, headache, fever, arthralgia, and lymphadenopathy that may precede or accompany the eruption; the latter follows the cleavage lines of the trunk creating the configuration of a Christmas tree and spontaneously resolves within 4 to 8 weeks...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28118642/methotrexate-induces-apoptosis-of-postpartum-placental-cytotrophoblasts
#18
Hao Yan, Zhihua Li, Zhonghai Yan, Xiuying Li, Xiaomei Li, Lin Yu, Chunhong Su, Dunjin Chen
BACKGROUND: Though methotrexate (MTX) is known to inhibit proliferation of trophoblasts derived from ectopic and intrauterine pregnancies, its action on trophoblasts derived from postpartum placenta remains questionable. This study was designed to ascertain the efficacy of MTX in inducing cell death of postpartum placental cytotrophoblasts (PPTC). METHODOLOGY: Primary human cytotrophoblasts were isolated from placentae of 1st and 2nd trimester intrauterine pregnancies and from postpartum placentae...
January 25, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28118360/the-world-health-organization-fetal-growth-charts-a-multinational-longitudinal-study-of-ultrasound-biometric-measurements-and-estimated-fetal-weight
#19
Torvid Kiserud, Gilda Piaggio, Guillermo Carroli, Mariana Widmer, José Carvalho, Lisa Neerup Jensen, Daniel Giordano, José Guilherme Cecatti, Hany Abdel Aleem, Sameera A Talegawkar, Alexandra Benachi, Anke Diemert, Antoinette Tshefu Kitoto, Jadsada Thinkhamrop, Pisake Lumbiganon, Ann Tabor, Alka Kriplani, Rogelio Gonzalez Perez, Kurt Hecher, Mark A Hanson, A Metin Gülmezoglu, Lawrence D Platt
BACKGROUND: Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity and reduced fetal growth, an issue of further interest given the mounting evidence that fetal growth in general is linked to degrees of risk of common noncommunicable diseases in adulthood. Against this background, WHO made it a high priority to provide the present fetal growth charts for estimated fetal weight (EFW) and common ultrasound biometric measurements intended for worldwide use...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28116109/a-case-of-a-surviving-co-twin-diagnosed-with-porencephaly-and-renal-hypoplasia-after-a-single-intrauterine-fetal-death-at-21-weeks-of-gestation-in-a-monochorionic-monoamniotic-twin-pregnancy
#20
Hidenori Machino, Takayuki Iriyama, Toshio Nakayama, Atsushi Komatsu, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
Monochorionic monoamniotic (MM) twin pregnancy carries a high risk of intrauterine fetal death (IUFD). Single IUFD in an MM twin pregnancy prior to 22 weeks of gestation has been reported to be strongly correlated with double twin demise. To our knowledge, there are no case reports on the natural course of a surviving co-twin in an MM twin pregnancy resulting in live birth after a single IUFD prior to 22 weeks of gestation. Here, we report a case of a surviving co-twin, after a single IUFD at 21 weeks of gestation in a MM twin pregnancy, with an antenatal diagnosis of renal hypoplasia and severe neurological damage leading to porencephaly, and live birth at 36 weeks of gestation...
January 2017: Oxford Medical Case Reports
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