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Intrauterine death

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https://www.readbyqxmd.com/read/28109180/the-intrauterine-renin-angiotensin-system-sex-specific-effects-on-the-prevalence-of-spontaneous-preterm-birth
#1
Kirsty G Pringle, Tamas Zakar, Eugenie R Lumbers
Preterm birth (PTB) is the single largest cause of death in infants and young children. The rate of PTB is significantly higher in male infants, particularly those that are born very preterm. Here we present evidence to suggest that the decidual renin-angiotensin system may play a role in inhibiting inflammation and maintaining the integrity of the fetal membranes during pregnancy, and that sex-specific alterations in the intrauterine RAS could contribute to the increased risk of PTB in male babies. Women carrying female fetuses have high levels of expression of decidual prorenin at term...
January 21, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28076990/outcomes-in-the-absence-of-the-ductus-venosus-diagnosed-in-the-first-trimester
#2
Hiroko Takita, Junichi Hasegawa, Tatsuya Arakaki, Shoko Hamada, Mayumi Tokunaka, Masamitsu Nakamura, Ryu Matsuoka, Akihiko Sekizawa
PURPOSE: To clarify the outcomes of the absence of the ductus venosus diagnosed in fetuses suspected to have a structural abnormality during a morphological assessment in the first trimester. METHODS: Infants in whom ultrasound fetal morphological assessments were attempted in the first trimester (11 to 13-6 weeks of gestation) and who were subsequently delivered between 2013 and 2015 at Showa University Hospital were enrolled. In cases in which the absence of the ductus venosus was diagnosed in the first trimester, the prognosis was assessed...
January 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28073874/successful-pregnancy-following-treatment-of-recurrent-chronic-histiocytic-intervillositis
#3
Leehe Vardi, Helen Paterson, Noelyn Anne Hung
Chronic histiocytic intervillositis (CHI) is a rare placental lesion associated with adverse obstetric outcomes and high recurrence rate. We report a case of six consecutive pregnancies in one woman, where CHI was detected following an intrauterine death in the fifth pregnancy, after being missed in four earlier losses. The successful sixth pregnancy was treated with a combination of immunosuppressive and antithrombotic agents. While low-molecular-weight heparin (LMWH) and aspirin had been shown to improve pregnancy outcome in recurrent pregnancy loss, there was limited evidence of improved outcome in CHI...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28071748/nrf2-regulates-gene-environment-interactions-in-an-animal-model-of-intrauterine-inflammation-implications-for-preterm-birth-and-prematurity
#4
Thomas E Sussan, Kuladeep Sudini, C Conover Talbot, Xiaobin Wang, Marsha Wills-Karp, Irina Burd, Shyam Biswal
Preterm birth (PTB) is the leading cause of neonatal mortality, and surviving infants are at increased risk for lifelong disabilities. Intrauterine inflammation is an etiological factor that drives PTB, and oxidative stress is associated with PTB. Nuclear erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that is the key regulator of the response to oxidative and inflammatory stress. Here, we used the established mouse model of intrauterine inflammation-induced PTB to determine whether Nrf2 is a modifier of susceptibility to PTB and prematurity-related morbidity and mortality in the offspring...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034657/failure-of-physiologic-transformation-of-spiral-arteries-endothelial-and-trophoblast-cell-activation-and-acute-atherosis-in-the-basal-plate-of-the-placenta
#5
Carlos A Labarrere, Hector L Dicarlo, Elaine Bammerlin, James W Hardin, Yeon M Kim, Piya Chaemsaithong, David M Haas, Ghassan S Kassab, Roberto Romero
BACKGROUND: Failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous preterm labor with intact or ruptured membranes. Spiral arteries with failure of physiologic transformation are prone to develop atherosclerotic-like lesions of atherosis. There are striking parallels between preeclampsia and atherosclerotic disease, and between lesions of atherosis and atherosclerosis. Endothelial activation, identified by intercellular adhesion molecule-1 (ICAM-1) expression, is present in atherosclerotic-like lesions of heart transplantation, and is considered a manifestation of rejection...
December 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28029583/acr-appropriateness-criteria-assessment-of-fetal-well-being
#6
Lynn Simpson, Nadia J Khati, Sandeep P Deshmukh, Kika M Dudiak, Mukesh G Harisinghani, Tara L Henrichsen, Benjamin J Meyer, David A Nyberg, Liina Poder, Thomas D Shipp, Carolyn M Zelop, Phyllis Glanc
Although there is limited evidence that antepartum testing decreases the risk for fetal death in low-risk pregnancies, women with high-risk factors for stillbirth should undergo antenatal fetal surveillance. The strongest evidence supporting antepartum testing pertains to pregnancies complicated by intrauterine fetal growth restriction secondary to uteroplacental insufficiency. The main ultrasound-based modalities to determine fetal health are the biophysical profile, modified biophysical profile, and duplex Doppler velocimetry...
October 28, 2016: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28005039/-intrauterine-pneumocystis-infection
#7
E R Samitova, T N Ermak, I E Koltunov, A N Kislyakov, N V Karazhas, T N Rybalkina, M Yu Kornienko
Pneumocystosis is well known as an opportunistic infection that is presently most frequently registered in patients with HIV infection and in those with other immunodeficiency states. Earlier, after the Second World War, Pneumocystis pneumonia was most commonly detected in debilitated and premature children; nosocomial outbreaks of pneumocystosis were studied in detail in the 1960s and 1970s. The pathogen is transmitted through the air, but a number of references indicate that it can be transmitted through the placenta...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28003695/anaesthesia-for-foetoscopic-laser-ablation-a-retrospective-study
#8
Vaishali Kumbhar, M Radhika, Parameswara Gundappa, Jayashree Simha, Prathima Radhakrishnan
BACKGROUND AND AIMS: Twin pregnancy with monochorionic placenta may be associated with arteriovenous vascular anastomosis of the placental vessels resulting in twin-to-twin transfusion syndrome (TTTS) and twin reversed arterial perfusion syndrome (TRAP). Foetoscopic LASER ablation (FLA) is the treatment of choice in reducing foetal mortality related to this. METHODS: A retrospective review of medical records of 41 FLA procedures for TTTS and TRAP were analysed for anaesthetic management...
December 2016: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28002532/stillbirth-in-dichorionic-twins-discordant-for-major-and-minor-anomaly-followed-by-asynchronous-delivery-a-rare-occurrence-case-presentation
#9
George Lucian Zorilă, Marius Cristian Marinaş, Maria Florea, Ciprian LaurenŢiu Pătru, Roxana Cristina Drăguşin, Răzvan Grigoraş Căpitănescu, Marian Valentin Zorilă, Roxana Eugenia Zăvoi, Cristiana Eugenia Simionescu, Dominic Gabriel Iliescu, Ştefania Tudorache
The single stillbirth long-term intrauterine retention in dichorionic twin pregnancy is rarely reported. Also, the birth of a fetus is followed in most cases by immediate expulsion of the second twin. We hereby present an unusual case of asynchronous delivery of dichorionic twins, associating discordance for major and minor anomaly. The intrauterine death of the twin A, presenting a large sacrococcygeal tumor, occurred in the second trimester. The deceased twin A was born at 29 weeks' gestational age (GA). The twin B was extracted by Caesarean section at 31 weeks and had a good outcome...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27999640/toxoplasmosis-in-iran-a-guide-for-general-physicians-working-in-the-iranian-health-network-setting-a-systematic-review
#10
REVIEW
Seyed Mohammad Alavi, Leila Alavi
BACKGROUND: Human toxoplasmosis is an important zoonotic infection worldwide which is caused by the intracellular parasite Toxoplasma gondii (T.gondii). The aim of this study was to review briefly the general aspects of toxoplasma infection in in Iranian health system network. METHODS: We searched published toxoplasmosis related articles in English databases including Science Direct, Pub Med, Scopus, Google Scholar, Magiran, Iran Medex, Iran Doc and Scientific Information Database (SID) for toxoplasmosis...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27994991/dynamics-of-a-pregnancy-when-two-become-four-a-case-report-and-literature-review
#11
Murid Javed, Nareman Altorairi, Hamad Alsufyan
The incidence of pregnancies with multiple gestational sacs has increased with the use of assisted reproductive technology because more than one embryo is frequently transferred. The splitting of one or more embryos further complicates the pregnancy. Some of these complications include intrauterine fetal death, growth restriction, discordant birth weight, and preterm delivery. Monozygotic twins suffer from a few unique complications including twin-twin transfusion syndrome, twin reversed arterial perfusion sequence, and twin anemia-polycythemia sequence...
November 11, 2016: Curēus
https://www.readbyqxmd.com/read/27969558/characteristics-of-the-offspring-of-women-with-a-history-of-malignancy-excluding-congenital-malformations
#12
Zahra Sabeti Rad, Britt Friberg, Emir Henic, Lars Rylander, Olof Ståhl, Bengt Källén, Göran Lingman
OBJECTIVE: To study the characteristics (except congenital malformations) of offspring born to women with a history of malignancy. METHODS: Data were obtained by linkage between four different Swedish national health registers. We compared the offspring born between 1994 and 2011 of women with a history of malignancy with all other infants. Survival of the infants was followed up through 2013. Adjusting for confounders was performed using Mantel-Haenszel methodology...
November 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27939481/aspirin-adherence-during-high-risk-pregnancies-a-questionnaire-study
#13
Carolien Nienke Heleen Abheiden, Alexandra Vera Ruth van Reuler, Wessel Willem Fuijkschot, Johanna Inge Petra de Vries, Abel Thijs, Marjon Alina de Boer
OBJECTIVE: Aspirin reduces the risk of recurrent hypertensive disorders of pregnancy (HD) and fetal growth restriction (FGR). This study examined the non-adherence rates of aspirin in women with high-risk pregnancies. STUDY DESIGN: All consecutive women between 24 and 36weeks gestation with an indication for aspirin use during pregnancy were invited for this study. A survey was used which included two validated questionnaires, the simplified medication adherence questionnaire (SMAQ) and the Beliefs and Behaviour Questionnaire (BBQ)...
October 2016: Pregnancy Hypertension
https://www.readbyqxmd.com/read/27932593/dexamethasone-induced-intrauterine-growth-restriction-is-associated-with-altered-expressions-of-metastasis-tumor-antigens-and-cell-cycle-control-proteins-in-rat-placentas
#14
Mariam Alqaryyan, Narayana Kilarkaje, Abdeslam Mouihate, Maie D Al-Bader
Molecular mechanisms affecting placental formation in intrauterine growth-restricted (IUGR) pregnancies are not clearly understood. Since metastasis tumor antigens (MTAs) MTA1 and MTA2 promote cell proliferation and MTA3 suppresses it, we hypothesized that IUGR alters cell survival/cell death programs driven by placental MTAs. To induce IUGR, pregnant Sprague Dawley rats were given daily intraperitoneal injections of either saline or dexamethasone (0.4 mg/kg) starting from 14 days of gestation (dg) to either 19 dg or 21 dg...
December 8, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27918564/interleukin-33-induced-expression-of-pibf1-by-decidual-b-cells-protects-against-preterm-labor
#15
Bihui Huang, Azure N Faucette, Michael D Pawlitz, Bo Pei, Joshua W Goyert, Jordan Zheng Zhou, Nadim G El-Hage, Jie Deng, Jason Lin, Fayi Yao, Robert S Dewar, Japnam S Jassal, Maxwell L Sandberg, Jing Dai, Montserrat Cols, Cong Shen, Lisa A Polin, Ronald A Nichols, Theodore B Jones, Martin H Bluth, Karoline S Puder, Bernard Gonik, Nihar R Nayak, Elizabeth Puscheck, Wei-Zen Wei, Andrea Cerutti, Marco Colonna, Kang Chen
Preterm birth (PTB) is a leading cause of neonatal death worldwide. Intrauterine and systemic infection and inflammation cause 30-40% of spontaneous preterm labor (PTL), which precedes PTB. Although antibody production is a major immune defense mechanism against infection, and B cell dysfunction has been implicated in pregnancy complications associated with PTL, the functions of B cells in pregnancy are not well known. We found that choriodecidua of women undergoing spontaneous PTL harbored functionally altered B cell populations...
January 2017: Nature Medicine
https://www.readbyqxmd.com/read/27917382/updates-on-the-methodological-approaches-for-carrying-out-an-in-depth-study-of-the-cardiac-conduction-system-and-the-autonomic-nervous-system-of-victims-of-sudden-unexplained-fetal-and-infant-death
#16
Graziella Alfonsi, Marina Crippa
This article contains a set of protocols for histopathological techniques that can be used for carrying out in-depth studies of cases of sudden infant death syndrome and sudden intrauterine unexplained fetal death syndrome. In order to enable researchers to advance hypotheses regarding the causes of the unexpected death of infants and fetuses, the authors propose three innovative and accurate methodologies for studying the cardiac conduction system, the peripheral cardiac nervous system, and the central autonomic nervous system...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27896247/uterine-rupture-in-pregnancies-following-myomectomy-a-multicenter-case-series
#17
Hee-Sun Kim, Soo-Young Oh, Suk-Joo Choi, Hyun-Soo Park, Geum-Joon Cho, Jin-Hoon Chung, Yong-Soo Seo, Sun-Young Jung, Jung-Eun Kim, Su-Hyun Chae, Han-Sung Hwang
OBJECTIVE: The purpose of this case series was to retrospectively examine records of cases with uterine rupture in pregnancies following myomectomy and to describe the clinical features and pregnancy outcomes. METHODS: This study was conducted as a multicenter case series. The patient databases at 7 tertiary hospitals were queried. Records of patients with a diagnosis of uterine rupture in the pregnancy following myomectomy between January 2012 and December 2014 were retrospectively collected...
November 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27893080/travel-associated-zika-virus-disease-acquired-in-the-americas-through-february-2016-a-geosentinel-analysis
#18
Davidson H Hamer, Kira A Barbre, Lin H Chen, Martin P Grobusch, Patricia Schlagenhauf, Abraham Goorhuis, Perry J J van Genderen, Israel Molina, Hilmir Asgeirsson, Phyllis E Kozarsky, Eric Caumes, Stefan H Hagmann, Frank P Mockenhaupt, Gilles Eperon, Elizabeth D Barnett, Emmanuel Bottieau, Andrea K Boggild, Philippe Gautret, Noreen A Hynes, Susan Kuhn, R Ryan Lash, Karin Leder, Michael Libman, Denis J M Malvy, Cecilia Perret, Camilla Rothe, Eli Schwartz, Annelies Wilder-Smith, Martin S Cetron, Douglas H Esposito
Background: Zika virus has spread rapidly in the Americas and has been imported into many nonendemic countries by travelers. Objective: To describe clinical manifestations and epidemiology of Zika virus disease in travelers exposed in the Americas. Design: Descriptive, using GeoSentinel records. Setting: 63 travel and tropical medicine clinics in 30 countries. Patients: Ill returned travelers with a confirmed, probable, or clinically suspected diagnosis of Zika virus disease seen between January 2013 and 29 February 2016...
January 17, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27871127/effect-of-maternal-position-on-fetal-behavioural-state-and-heart-rate-variability-in-healthy-late-gestation-pregnancy
#19
Peter R Stone, Wendy Burgess, Jordan P R McIntyre, Alistair J Gunn, Christopher A Lear, Laura Bennet, Edwin A Mitchell, John M D Thompson
KEY POINTS: Fetal behavioural state in healthy late gestation pregnancy is affected by maternal position. Fetal state 1F is more likely to occur in maternal supine or right lateral positions. Fetal state 4F is less likely to occur when the woman lies supine or semi-recumbent. Fetal state change is more likely when the woman is supine or semi-recumbent. Fetal heart rate variability is affected by maternal position with variability reduced in supine and semi-recumbent positions. ABSTRACT: Fetal behavioural states (FBS) are measures of fetal wellbeing...
November 21, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27865347/gestational-food-restriction-decreases-placental-interleukin-10-expression-and-markers-of-autophagy-and-endoplasmic-reticulum-stress-in-murine-intrauterine-growth-restriction
#20
Alison Chu, Shanthie Thamotharan, Amit Ganguly, Madhuri Wadehra, Matteo Pellegrini, Sherin U Devaskar
Intrauterine growth restriction (IUGR) affects up to 10% of pregnancies and often results in short- and long-term sequelae for offspring. The mechanisms underlying IUGR are poorly understood, but it is known that healthy placentation is essential for nutrient provision to fuel fetal growth, and is regulated by immunologic inputs. We hypothesized that in pregnancy, maternal food restriction (FR) resulting in IUGR would decrease the overall immunotolerant milieu in the placenta, leading to increased cellular stress and death...
October 2016: Nutrition Research
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