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https://www.readbyqxmd.com/read/29777227/in-utero-exposure-to-gestational-diabetes-and-adiposity-does-breastfeeding-make-a-difference
#1
L L Hui, A M Li, E A S Nelson, G M Leung, S L Lee, C M Schooling
BACKGROUND/OBJECTIVES: Short-term breastfeeding from mothers with gestational diabetes (GDM) may programme metabolism and increase offspring diabetes risk. We examined the association of in utero GDM exposure with adiposity from infancy to adolescence, and whether any association was modified by breastfeeding during early infancy. METHODS: In the prospective Chinese birth cohort "Children of 1997" (n = 7342, 88% follow-up rate), generalised estimate equations with multiple imputation were used to assess associations of in utero GDM exposure with age- and sex-specific body mass index (BMI) z-score during infancy (3 and 9 months), childhood (2- < 8 years) and adolescence (8-16 years), adjusted for sex, parity, maternal age, birth place, preeclampisa, smoking, and family socio-economic position...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29774363/developmental-dysplasia-of-the-hip-why-are-we-still-operating-on-them-a-plea-for-institutional-newborn-clinical-screening
#2
Wu Chean Lee, Sumanth Kumar Gera, Arjandas Mahadev
INTRODUCTION: Developmental dysplasia of the hip (DDH) is a common orthopaedic condition at birth. Non-surgical management with Pavlik harness can effectively treat DDH with early clinical diagnosis at newborn, but open surgeries continue to be performed. We aimed to elucidate the reasons for this. METHODS: A retrospective review was performed of all open surgeries related to DDH from 2006 to 2016. Patients were either born at our institution (Group 1) or outside of it (Group 2)...
May 18, 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29770094/travel-related-zika-virus-cases-in-canada-october-2015-june-2017
#3
J Tataryn, L Vrbova, M Drebot, H Wood, E Payne, S Connors, J Geduld, M German, K Khan, P A Buck
Background: Zika virus (ZIKV) is an emerging mosquito-borne disease that can cause severe birth defects if contracted congenitally. Since late 2015, there has been a large increase in the number of travel-related cases of Zika virus infection in Canada. Objective: The objective of this study was to describe the epidemiology of travel-related Zika cases in Canada from October 2015 to June 2017 and review them in the context of the international outbreak in the Americas...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29769421/low-placental-visfatin-expression-is-related-to-impaired-glycaemic-control-and-fetal-macrosmia-in-pregnancies-complicated-by-type-1-diabetes
#4
R Iciek, M Brazert, E Wender-Ozegowska, M Pietryga, J Brazert
Type 1 diabetes mellitus (T1DM) is still related to altered fetal growth and severe maternal complications. We studied the possible role of placental visfatin/nicotinamide phosphoribosyltransferase (NAMPT) in fetal development in T1DM pregnancies, the possible role of placental visfatin in fetal macrosomia. Sixty five pregnant women with T1DM and singleton pregnancy were qualified into the study. Placental visfatin expression was by analysed by RT-PCR. We demonstrated the lowest expression of placental visfatin in women who delivered neonates with birth weight NBW > 4000 g (0...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29767630/characterization-of-cardiorespiratory-phase-synchronization-and-directionality-in-late-premature-and-full-term-infants
#5
Maristella Lucchini, Nicolo Pini, William P Fifer, Nina Burtchen, Maria G Signorini
OBJECTIVE: Though the mutual influence of cardiovascular and respiratory rhythms in healthy newborns has been documented, its full characterization is still pending. In general, activity of many physiological subsystems has a well expressed rhythmic character, and often an interdependency between physiological rhythms emerges early in development. Traditional methods of data analysis only address the quantification of the strength of subsystem interactions. In this work, we will investigate system interrelationships in terms of possible presence of causal or directional interplays...
May 16, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29765291/the-potential-close-future-of-hemophilia-treatment-gene-therapy-tfpi-inhibition-antithrombin-silencing-and-mimicking-factor-viii-with-an-engineered-antibody
#6
REVIEW
Wolfgang Korte, Lukas Graf
Summary Hemophilia is one of the best researched monogenic diseases. Hemophilia A will affect approximately 1:5,000 male live births. In recent decades, great progress has been made with the introduction of recombinant proteins in the 1990s for therapy and prophylaxis, securing adequate availability and, with the introduction of the prophylaxis concept, reducing the negative impact of hemophilia on morbidity (especially arthropathy). Despite this progress, there are still challenges to overcome to secure adequate prophylaxis and treatment: for the time being, causal pharmacological hemophilia prophylaxis and therapy requires repeated i...
April 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29764430/drug-prescribing-during-pregnancy-in-a-central-region-of-italy-2008-2012
#7
Martina Ventura, Alice Maraschini, Paola D'Aloja, Ursula Kirchmayer, Ilaria Lega, Marina Davoli, Serena Donati
BACKGROUND: Drug consumption during pregnancy is a matter of concern, especially regarding drugs known or suspected to be teratogens. Little is known about drug use in pregnant women in Italy. The present study is aimed at examining the prevalence, and to detect potential inappropriateness of drug prescribing among pregnant women in Latium, a region of central Italy. METHODS: This retrospective study was conducted on a cohort of women aged 18-45 years who delivered between 2008 and 2012 in public hospitals...
May 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29762087/genomics-and-epigenomics-of-congenital-heart-defects-expert-review-and-lessons-learned-in-africa
#8
Nicholas Ekow Thomford, Kevin Dzobo, Nana Akyaa Yao, Emile Chimusa, Jonathan Evans, Emmanuel Okai, Paul Kruszka, Maximilian Muenke, Gordon Awandare, Ambroise Wonkam, Collet Dandara
Congenital heart defects (CHD) are structural malformations found at birth with a prevalence of 1%. The clinical trajectory of CHD is highly variable and thus in need of robust diagnostics and therapeutics. Major surgical interventions are often required for most CHDs. In Africa, despite advances in life sciences infrastructure and improving education of medical scholars, the limited clinical data suggest that CHD detection and correction are still not at par with the rest of the world. But the toll and genetics of CHDs in Africa has seldom been systematically investigated...
May 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29760105/triplets-birthweight-and-handedness
#9
Kauko Heikkilä, Catharina E M Van Beijsterveldt, Jari Haukka, Matti Iivanainen, Aulikki Saari-Kemppainen, Karri Silventoinen, Dorret I Boomsma, Yoshie Yokoyama, Eero Vuoksimaa
The mechanisms behind handedness formation in humans are still poorly understood. Very low birthweight is associated with higher odds of left-handedness, but whether this is due to low birthweight itself or premature birth is unknown. Handedness has also been linked to development, but the role of birthweight behind this association is unclear. Knowing that birthweight is lower in multiple births, triplets being about 1.5 kg lighter in comparison with singletons, and that multiples have a higher prevalence of left-handedness than singletons, we studied the association between birthweight and handedness in two large samples consisting exclusively of triplets from Japan ( n = 1,305) and the Netherlands ( n = 947)...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29756650/stillbirth-rates-across-three-ape-species-in-accredited-american-zoos
#10
Sana T Saiyed, Rebecca C Liubicich, Mason Fidino, Stephen R Ross
Stillbirths, or births of infants that died in the womb, represent a failure of the materno-feto-placental unit to maintain a suitable fetal environment. Typical studies of nonhuman primate (NHP) stillbirth patterns are primarily descriptive and focus on macaques (genus Macaca). Thus, less is known about other NHP species and rarer still are studies that examine possible biological factors that influence stillbirth rates across taxa. To examine possible contributors to stillbirths in great apes, we analyzed 36 years (1980-2016) of historical data documenting births of zoo-housed chimpanzees (Pan troglodytes, N = 391), western lowland gorillas (Gorilla gorilla gorilla, N = 491), and orangutans (Pongo spp, N = 307) in accredited zoological parks in the United States...
May 14, 2018: American Journal of Primatology
https://www.readbyqxmd.com/read/29753950/structure-of-the-lps-o-chain-from-fusobacterium-nucleatum-strain-mjr-7757-b
#11
Evgeny Vinogradov, Frank St Michael, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and still births. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report the following structure of the lipopolysaccharide O-chain of F. nucleatum strain MJR 7757 B:where Lac is (R)-1-carboxyethyl (lactic acid residue); all monosaccharides are in the pyranose form...
April 25, 2018: Carbohydrate Research
https://www.readbyqxmd.com/read/29753923/prevalence-of-valproate-syndrome-in-europe-from-2005-to-2014-a-registry-based-multi-centre-study
#12
Joan K Morris, Ester Garne, Maria Loane, Marie-Claude Addor, Ingeborg Barisic, Fabrizio Bianchi, Miriam Gatt, Monica Lanzoni, Catherine Lynch, Olatz Mokoroa, Vera Nelen, Amanda Neville, Mary T O'Mahony, Hanitra Randrianaivo-Ranjatoelina, Anke Rissmann, David Tucker, H E K de Walle, Nataliia Zymak-Zakutnia, Judith Ankin
Women with epilepsy need to continue to take anticonvulsants during their pregnancies to prevent seizures from occurring. Since the 1980's, it has been known that the use of valproate (an anticonvulsant) in the first trimester of pregnancy is associated with an increased risk of spina bifida. Recent studies have also demonstrated increased risks of other congenital anomalies as well as a risk of cognitive impairment. Doctors in the EU are now advised not to prescribe valproate in pregnant women, in women who can become pregnant or in girls unless other treatments are ineffective or not tolerated...
May 10, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29752892/high-vertical-hiv-transmission-rate-in-the-midwest-region-of-brazil
#13
Vanessa Terezinha Gubert de Matos, Fabiani de Morais Batista, Naiara Valera Versage, Clarice Souza Pinto, Vanessa Marcon de Oliveira, Érica Freire de Vasconcelos Pereira, Roberta Barbeta Dos Rios de Matos, Márcia Maria Ferrairo Janini Dal Fabbro, Ana Lúcia Lyrio de Oliveira
OBJECTIVES: To estimate vertical HIV transmission rate in a capital city of the Midwest region of Brazil and describe the factors related to transmission. METHODS: A descriptive epidemiological study based on the analysis of secondary data from the Notifiable Diseases Information System (SINAN). The analysis considered all HIV-infected pregnant women with delivery in Campo Grande-MS in the years 2007-2013 and their HIV-exposed infants. RESULTS: A total of 218 births of 176 HIV-infected pregnant women were identified during the study period, of which 187 infants were exposed and uninfected, 19 seroconverted, and 12 were still inconclusive in July 2015...
May 9, 2018: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29752725/identification-of-neun-immunopositive-cells-in-the-adult-mouse-subventricular-zone
#14
Kengo Saito, Taro Koike, Fumiaki Kawashima, Hirofumi Kurata, Taku Shibuya, Takemasa Satoh, Yoshio Hata, Hisao Yamada, Tetsuji Mori
In the adult rodent subventricular zone (SVZ), there are neural stem cells (NSCs) and the specialized neurogenic niche is critical to maintain their stemness. . To date, many cellular and non-cellular factors that compose the neurogenic niche and markers to identify subpopulations of Type A cells have been confirmed. In particular, neurotransmitters regulate adult neurogenesis and mature neurons in the SVZ have been only partially analyzed. Moreover, Type A cells, descendants of NSCs, are highly heterogeneous and more molecular markers are still needed to identify them...
May 11, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29751781/full-normalization-of-severe-hypertension-after-parathryoidectomy-a-case-report-and-systematic-review
#15
Andreea Corina Sofronie, Isabelle Kooij, Claude Bursot, Giulia Santagati, Jean-Philippe Coindre, Giorgina Barbara Piccoli
BACKGROUND: Although the relationship between hyperparathyroidism and hypertension has been described for decades, the role of hyperparathyroidism in hypertension in dialysis is still unclear. Following the case of a severely hypertensive dialysis patient, in which parathyroidectomy (PTX) corrected the metabolic imbalance and normalized blood pressure (BP), we tried to contextualize our observation with a systematic review of the recent literature on the effect of PTX on BP. CASE PRESENTATION: A dialysis patient, aged 19 years at the time of this report, with chronic kidney disease (CKD) from childhood; he was an early-preterm baby with very low birth weight (910 g), and is affected by a so-far unidentified familial nephropathy...
May 11, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29748651/advances-in-assessing-body-composition-during-pregnancy
#16
REVIEW
Jasper Most, Kara Lynn Marlatt, Abby Duhé Altazan, Leanne Maree Redman
The prevalence of excess gestational weight gain is increasing worldwide and is associated with pregnancy complications, including gestational diabetes mellitus, pre-eclampsia, preterm birth, macrosomia, and development of obesity in offspring. Whereas gestational weight gain positively correlates with the gain in fat mass (FM), fat-free mass (FFM) gain is relatively consistent across pregnancies. Commonly used methods to assess body composition include anthropometry, densitometry (air displacement plethysmography, underwater weighing), and hydrometry (isotope dilution, bioimpedance analysis)...
May 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29745312/comparing-patient-demographics-and-tumor-characteristics-of-hiv-positive-and-hiv-negative-patients-with-cancer-in-south-carolina
#17
Benjamin D Hallowell, Kristina W Kintziger, Wayne A Duffus, John E Vena, Sara W Robb
We compared the demographic and disease characteristics of HIV-positive (HIV+) and HIV-negative (HIV-) individuals with a diagnosis of cancer in South Carolina. HIV-positive patients with cancer were reflective of the HIV+ caseload in South Carolina, with HIV+ patients with cancer more likely to be male (odds ratio [OR]: 2.78: 95% confidence interval [CI]: 2.33-3.32), black (OR: 7.68; 95% CI: 6.52-9.06), and younger at cancer diagnosis (OR: 0.92; 95% CI: 0.91-0.92). Controlling for year of birth, HIV+ patients with cancer did not receive cancer diagnoses at a younger age than HIV- controls...
January 2018: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/29744996/hematopoietic-stem-cell-transplantation-without-in-vivo-t-cell-depletion-for-pediatric-aplastic-anemia-a-single-center-experience
#18
Sidan Li, Bin Wang, Lingling Fu, Yilin Pang, Guanghua Zhu, Xuan Zhou, Jie Ma, Yan Su, Maoquan Qin, Runhui Wu
For young patients, HLA-MRD HSCT is the first-line treatment of SAA. However, due to China's birth control policy, few patients could find suitable sibling donors and HLA-MUD. More and more transplantation centers have used Haplo-D as the donor source for young adult and pediatric patients. However, studies with larger amount of pediatric patients are rare. We retrospectively analyzed the data of children with AA who were treated with allogeneic HSCT and compared the therapeutic efficacy of Haplo-HSCT and MRD/MUD group...
May 10, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29744475/microscopic-varicocelectomy-as-a-treatment-option-for-patients-with-severe-oligospermia
#19
Chirag Gupta, Arun Chinchole, Rupin Shah, Hemant Pathak, Deepa Talreja, Ankit Kayal
Purpose: Many studies have shown improved semen parameters after varicocele surgery; however, the benefit in terms of improved pregnancy rates and live births is still disputed in cases of severe oligoasthenozoospermia (OAS). The present study evaluated the outcome of microscopic subinguinal varicocelectomy in terms of the spontaneous pregnancy rate in patients with severe OAS. Materials and Methods: This was a retrospective, observational, analytic study of 56 men with OAS who underwent microscopic varicocelectomy at our center between 2008 and 2015...
May 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29740501/risk-factors-of-neonatal-mortality-and-child-mortality-in-bangladesh
#20
Md Maniruzzaman, Harman S Suri, Nishith Kumar, Md Menhazul Abedin, Md Jahanur Rahman, Ayman El-Baz, Makrand Bhoot, Jagjit S Teji, Jasjit S Suri
Background: Child and neonatal mortality is a serious problem in Bangladesh. The main objective of this study was to determine the most significant socio-economic factors (covariates) between the years 2011 and 2014 that influences on neonatal and child mortality and to further suggest the plausible policy proposals. Methods: We modeled the neonatal and child mortality as categorical dependent variable (alive vs death of the child) while 16 covariates are used as independent variables using χ2 statistic and multiple logistic regression (MLR) based on maximum likelihood estimate...
June 2018: Journal of Global Health
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