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esophagogastric adenocarcinoma

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https://www.readbyqxmd.com/read/29662932/combined-extensive-esophageal-squamous-papillomas-and-florid-cardiac-gland-hyperplasia-in-a-patient-with-adenocarcinoma
#1
Takanori Suganuma, Han-Seung Yoon
We report a rare case of extensive esophageal squamous papillomas (ESPs) involving the entire esophagus and florid cardiac gland hyperplasia involving only the lower esophagus in a 39-year-old woman with heartburn and epigastric distress for the past 2 years. Previous esophagogastroduodenoscopy showed multiple ESPs involving the entire esophagus extending 38 cm from the esophageal orifice to the esophagogastric junction (EGJ). Additionally, prominent cardiac gland hyperplasia over the esophageal posterior wall was exhibited extending 12 cm from the mid-esophagus to the EGJ...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29650836/-a-case-of-advanced-esophagogastric-junction-cancer-responding-to-s-1-neoadjuvant-chemotherapy
#2
Junko Kuroda, Hisae Aoki, Naoko Kondou, Toshiyuki Sumita, Kei Itoh, Senichirou Agawa
A 56-year-old man was diagnosed with advanced adenocarcinoma of the esophagogastric junction. He received 1 course of neoadjuvant chemotherapy with S-1. After neoadjuvant chemotherapy, the primary tumor showed a remarkable decrease in size. Subtotalesophagectomy, D2 lymph node dissection, and reconstruction with a gastric tube through the posterior mediastinal route were performed. Pathological examination showed that most of the cancer cells had been destroyed, with a part where adenocarcinoma mucosa was seen...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29600362/processing-of-surgical-specimen-esophagogastrectomy-for-esophageal-adenocarcinoma
#3
Benjamin M Allanson, M Priyanthi Kumarasinghe
An esophagogastrectomy is a surgical procedure that is performed for treatment of confirmed localized esophageal and esophagogastric junction adenocarcinoma. Proper macroscopic assessment and cut-up technique is essential to ensure that the overall assessment is correct and reproducible. Here, we describe a standard for macroscopic assessment and dissection to be used for routine handling of esophagogastrectomy specimens in the clinical laboratory.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29600357/chemotherapy-for-esophageal-adenocarcinoma
#4
Ka-On Lam, Dora L W Kwong
Esophageal and esophagogastric junction adenocarcinoma is a distinct entity from esophageal squamous cell carcinoma with respect to etiology and biology despite sharing the same anatomical location. While most international treatment guidelines recommend a similar management strategy for both esophageal squamous and adenocarcinoma histologies, the evidence for treating adenocarcinoma are indeed more often extrapolated from that of gastric carcinoma. In this chapter, the best evidences for the management of this distinct disease with chemotherapy in both curative and palliative clinical settings are presented...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29600356/radiotherapy-for-esophageal-adenocarcinoma
#5
Dora L W Kwong, K O Lam
Adenocarcinomas occur in distal esophagus and often involve esophagogastric junction. Radiotherapy plays a key role in treatment, often in combination with chemotherapy and surgery in multi-modalities management. For resectable esophageal primaries, neoadjuvant chemoradiotherapy plus surgery can downstage disease and improve outcome over surgery alone. For patients with unresectable primaries or medically unfit for surgery, definitive chemoradiotherapy was found to improve survival over radiotherapy alone. For patients who had residual disease or involved margins after primary surgery, adjuvant chemoradiotherapy in postoperative setting was shown to improve local control and survival...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29600355/introduction-esophageal-adenocarcinoma-updates-of-current-status
#6
Alfred K Lam
Esophageal and esophagogastric adenocarcinoma is highly prevalent in the Western populations and is a major cause of cancer-related morbidity and mortality worldwide. The incidence of esophageal adenocarcinoma is rapidly rising in the Western populations. The major predisposing diseases and pathogenesis (gastro-esophageal reflux disease, Barrett esophagus, and dysplasia) of the cancer are well known. There is an urgent need for works of the multidisciplinary teams (clinical, pathological, the molecular biology and translational research) for improved outcomes of patients with this cancer...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29577671/prognostic-significance-of-nfia-and-nfib-in-esophageal-squamous-carcinoma-and-esophagogastric-junction-adenocarcinoma
#7
Bo Yang, Zhi-Hang Zhou, Li Chen, Xiang Cui, Jun-Yan Hou, Kai-Jie Fan, Si-Hao Han, Peng Li, Shao-Qiong Yi, Yang Liu
The nuclear factor I (NFI) family members, especially NFIA and NFIB, play essential roles in cancers. The roles of NFIA and NFIB in esophageal squamous cell carcinoma (ESCC) and esophagogastric junction adenocarcinoma (EJA) remain poorly known. This study aimed to determine the expression of NFIA and NFIB in ESCC and EJA and elucidate their prognostic significance. The expression of NFIA and NFIB was examined in 163 ESCC samples and 26 EJA samples by immunohistochemistry. The results showed that high NFIA expression correlated significantly with poor differentiation, lymph node metastasis, and advanced TNM stage in patients with ESCC...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29575837/-clinical-value-of-endoscopicultrsaonography-and-multi-slice-spiral-ct-in-siewert-%C3%A2-and-%C3%A2-type-adenocarcinoma-of-esophagogastric-junction
#8
G L Zheng, J J Li, G Q Xiang, J Zhu, Y Zhao, H T Zhu, D Yang, Y Wang, J Zhang, X Y Meng, Z C Zheng
Objective: To investigate the clinical value of endoscopic ultrasonography (EUS) and Multi-slice Spiral CT (MSCT) in the preoperativestaging of tumor(T) and lymph node (N) metastasis in patients with SiewertⅡand Ⅲ typeadenocarcinoma of esophagogastric junction(AEG). Methods: Clinical data of 145 Siewert Ⅱ and Ⅲ type AEG patientswithout preoperative chemoradiotherapy were retrospectively reviewed. Theyall received preoperative EUS and MSCT examination and underwent surgical resection, and the results of EUS and MSCT were compared with their postoperative pathologic staging...
March 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29572113/long-term-results-of-hand-assisted-laparoscopic-gastrectomy-for-advanced-siewert-type-ii-and-type-iii-esophagogastric-junction-adenocarcinoma
#9
Peng Zhang, Xuedong Zhang, Huanzhou Xue
BACKGROUND: Hand-assisted laparoscopic surgery (HALS) combines laparoscopic surgery with the tactile feedback of a hand-assist device for complex laparoscopic operations. This study aimed to comparatively evaluate the long-term outcomes of patients who underwent HALS versus open surgery for the treatment of advanced Siewert type II and type III adenocarcinoma of the esophagogastric junction (AEG). METHODS: A retrospective analysis of 77 patients with advanced Siewert type II and IIIAEG between March 2010 and March 2011...
March 20, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29549902/the-optimal-lymph-node-dissection-in-patients-with-adenocarcinoma-of-the-esophagogastric-junction
#10
Cecilie Okholm, Kaare Terp Fjederholt, Frank Viborg Mortensen, Lars Bo Svendsen, Michael Patrick Achiam
OBJECTIVE: The aim of this study was to refine the optimal lymph node dissection in Western patients with adenocarcinoma of the esophagogastric junction (AEG). BACKGROUND: Lymphadenectomy is essential in addition to surgery for AEG. Asian studies continually present superior survival rates using a more extended lymphadenectomy compared with results reproduced in the West. Thus, the optimal extend of the lymphadenectomy remains unclear in Western patients. METHODS: A retrospective cohort was conducted of patients with AEG from January 1st, 2003 to December 31st, 2011...
March 2018: Surgical Oncology
https://www.readbyqxmd.com/read/29539629/treatment-outcomes-of-endoscopic-submucosal-dissection-for-adenocarcinoma-originating-from-long-segment-barrett-s-esophagus-versus-short-segment-barrett-s-esophagus
#11
Tomoki Shimizu, Junko Fujisaki, Masami Omae, Akira Yamasaki, Yusuke Horiuchi, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Tomohiro Tsuchida
BACKGROUND: In recent years, effective outcomes of endoscopic submucosal dissection (ESD) for esophagogastric junction cancer including short-segment Barrett's esophagus (SSBE) cancer have been reported. However, the efficacy of ESD for long-segment Barrett's esophagus (LSBE) cancer is unknown. AIM: To clarify the treatment outcomes of ESD for LSBE cancer versus SSBE cancer. METHODS: A total of 86 patients with 91 superficial Barrett's esophageal adenocarcinomas who underwent ESD were enrolled; of these, 68 had underlying SSBE and 18 had LSBE...
March 14, 2018: Digestion
https://www.readbyqxmd.com/read/29509530/current-management-of-locally-advanced-junction-esophagogastric-adenocarcinoma
#12
Rodica Birla, Petre Hoara, Andrei Caragui, Marica Cristian, Silviu Constantinoiu
Adenocarcinoma of the gastroesophageal junction is more common in the West. Preoperative chemotherapy or chemoradiotherapy is performed for locally advanced disease. Recent studies are suggesting higher rates of curative resection and reduced rates of local recurrence in patients with neoadjuvant combination of chemotherapy and radiation therapy. The role of targeted agents in neoadjuvant therapy is under investigation.
January 2018: Chirurgia
https://www.readbyqxmd.com/read/29467943/the-modified-glasgow-prognostic-score-is-an-independent-prognostic-indicator-in-neoadjuvantly-treated-adenocarcinoma-of-the-esophagogastric-junction
#13
Gerd Jomrich, Marlene Hollenstein, Maximilian John, Andreas Baierl, Matthias Paireder, Ivan Kristo, Aysegül Ilhan-Mutlu, Reza Asari, Matthias Preusser, Sebastian F Schoppmann
The modified Glasgow Prognostic Score (mGPS) combines the indicators of decreased plasma albumin and elevated CRP. In a number of malignancies, elevated mGPS is associated with poor survival. Aim of this study was to investigate the prognostic role of mGPS in patients with neoadjuvantly treated adenocarcinomas of the esophagogastric junction 256 patients from a prospective database undergoing surgical resection after neoadjuvant treatment between 2003 and 2014 were evaluated. mGPS was scored as 0, 1, or 2 based on CRP (>1...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29457212/a-case-of-alpha-fetoprotein-producing-adenocarcinoma-of-the-esophagogastric-junction-in-which-long-term-survival-was-achieved-by-means-of-individualized-multidisciplinary-therapy
#14
Kazuyuki Tanaka, Mikihiro Fujiya, Masami Ijiri, Keitaro Takahashi, Katsuyoshi Ando, Yoshiki Nomura, Nobuhiro Ueno, Shin Kashima, Takuma Goto, Junpei Sasajima, Takahiro Ito, Kentaro Moriichi, Yusuke Mizukami, Hiroki Tanabe, Toshikatsu Okumura
No abstract text is available yet for this article.
February 19, 2018: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29456713/-in-vitro-study-on-the-role-of-sox9-in-trastuzumab-resistance-of-adenocarcinoma-of-the-esophagogastric-junction
#15
Yingcai Hong, Huaisheng Chen, Zhanpeng Rao, Bin Peng, Hong Hu, Shaolin Lin, Zhenglei Xu
Trastuzumab is recommended for the treatment of human epidermal growth factor receptor 2-positive adenocarcinoma of the esophagogastric junction (AEG) in combination with chemotherapy; however, drug resistance has severely affected its clinical application. The present study aimed to investigate the effect of sex determining region Y-box 9 (SOX9), a prognostic marker in adjuvant oncological settings, on AEG cell proliferation and apoptosis in the presence or absence of trastuzumab. Furthermore, the molecular mechanism underlying the role of SOX9 in trastuzumab resistance was explored...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29421911/intrathoracic-leak-after-an-ivor-lewis-procedure-for-an-esophageal-neoplasm-treated-with-a-stent
#16
Natalia Afonso Luis, María Asunción Acosta Mérida, Joaquín Marchena Gómez
A 75-year-old male who underwent an Ivor Lewis esophagectomy due to a distal adenocarcinoma had a leak at the gastroplasty on the 5th day after surgery, which required two surgeries and a primary suture. He was transferred to our hospital due to a poor outcome and endoscopy revealed a 2.5cm gap perianastomotically on the gastroplasty wall, for which a stent was placed. Due to hemodynamic impairment, a thoracotomy procedure was performed, which revealed stent protrusion into the cavity. The patient underwent an esophagogastric anastomosis resection, cervical esophagostomy and gastrostomy...
April 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29417228/comparison-of-long-term-clinical-outcomes-between-endoscopic-and-surgical-resection-for-early-stage-adenocarcinoma-of-the-esophagogastric-junction
#17
Hyun Ju Kim, Hyunsoo Chung, Sung Kwan Shin, Hyoung-Il Kim, Jun Chul Park, Sang Kil Lee, Woo Jin Hyung, Yong Chan Lee, Sung Hoon Noh
BACKGROUND: The aim of this study was to analyze long-term clinical and oncologic outcomes in patients with early-stage adenocarcinoma of the esophagogastric junction (AEG) managed with either endoscopic resection (ER) or surgery. METHODS: The inclusion criteria were AEG, meeting classic or expanded indications for ER of early gastric cancer, and complete resection. A total of 66 patients with Siewert type II AEG were included (ER group, n = 38; vs. surgery group, n = 28)...
February 7, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29395438/comparison-of-preoperative-concurrent-chemoradiotherapy-with-chemotherapy-alone-in-patients-with-locally-advanced-siewert-ii-and-iii-adenocarcinoma-of-the-esophagogastric-junction
#18
Xueke Ge, Qun Zhao, Yuzhi Song, Jing Li, Ming Liu, Wenwen Bai, Xueying Qiao
PURPOSE: Preoperative therapy improves overall survival (OS) after surgery in patients with adenocarcinoma of the esophagogastric junction (AEG). We aimed to retrospectively analyze whether preoperative chemoradiotherapy (CRT) could improve the prognosis of patients with locally advanced Siewert II and III AEG comparing with preoperative chemotherapy alone (CT). PATIENTS AND METHODS: From March 2012 to December 2015, 170 patients with locally advanced (cT3-4NxM0) Siewert II and III AEG were treated with preoperative CRT or CT in Hebei Medical University Fourth Hospital, and 123 patients were included in this study to compare the effects of preoperative CRT with CT...
January 9, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29394830/-prolonged-survival-following-chemotherapy-in-bone-marrow-carcinomatosis-due-to-esophagogastric-junctional-carcinoma-a-case-report
#19
Yusuke Fujii, Noriyuki Hirahara, Shunsuke Kaji, Yoshiko Miyazaki, Takashi Kishi, Takahito Taniura, Ryoji Hyakudomi, Tetsu Yamamoto, Takeshi Nishi, Hikota Hayashi, Yasunari Kawabata, Yoshitsugu Tajima
A 60s-year-old Japanese male underwent curative resection for an advanced adenocarcinoma of the esophagogastric junction(Stage III C), followed by adjuvant chemotherapy.Twenty -one months later, he was admitted to our hospital with a complaint of marked decline in activities of daily living(ADL).The patient was diagnosed with pancytopenia, disseminated intravascular coagulation(DIC), multiple lymph node and bone metastases, and bone marrow carcinomatosis.After completing a sufficient informed consent process, he received chemotherapy along with blood transfusion, and then DIC, pancytopenia, and ADL of the patient improved...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29394816/-a-case-of-recurrent-stenosis-after-metallic-stenting-for-esophagogastric-junction-adenocarcinoma-with-peritoneal-metastases
#20
Toshiki Hirakawa, Junya Morimoto, Kazunori Nakazawa, Hironari Miyamoto, Takuma Okada, Chihoko Nobori, Shigeaki Kurihara, En Wang, Naoki Aomatsu, Takehiko Iwauchi, Shigehito Yamagata, Yasutake Uchima, Kazuhiro Takeuchi
A 65-year-old man presented with severe strictures from the esophagogastric junction to the body of the stomach and was histopathologically diagnosed with adenocarcinoma. Computed tomography showed multiple peritoneal metastases. A long, covered metallic stent was placed, and chemotherapy was started. Subsequent granulation from the oral side of the stent caused stricture formation, and a covered stent was also placed. After 8 months, granulation from the oral side of the stent caused recurrent stricture formation...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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