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https://www.readbyqxmd.com/read/29779696/preliminary-study-of-magnetically-controlled-capsule-gastroscopy-for-diagnosing-superficial-gastric-neoplasia
#1
Yang-Yang Qian, Shu-Guang Zhu, Xi Hou, Wei Zhou, Wei An, Xiao-Ju Su, Mark Edward McAlindon, Zhao-Shen Li, Zhuan Liao
BACKGROUND: Magnetically controlled capsule gastroscopy (MCCG) is a newly developed non-invasive method designed for gastric examination. Although favorable diagnostic accuracy has been reported, there is little if any data about its ability to diagnose gastric cancer. AIMS: To compare the detectability of superficial gastric neoplasia by MCCG and gastroscopy. METHODS: This study was a self-controlled comparison study. Ten subjects diagnosed with superficial gastric neoplasia and scheduled to undergo endoscopic submucosal dissection (ESD) at a tertiary hospital were prospectively invited for an MCCG examination...
April 24, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29764500/the-role-of-initial-18-f-fdg-pet-ct-in-the-management-of-patients-with-suspected-extramedullary-plasmocytoma
#2
Linqi Zhang, Xu Zhang, Qiao He, Rusen Zhang, Wei Fan
BACKGROUND: Extramedullary plasmacytoma (EMP) is a plasma cell malignancy that originates in soft tissues without evidence of systemic spread, and its management differs from other plasma cell neoplasms. The purpose of the present study was to evaluate the role of initial 18 F-FDG PET/CT in the management of patients with clinical suspected EMP. METHODS: 18 F-FDG PET/CT scans performed in 21 patients (M/F = 12/9, mean age 51.1 ± 15.3 years) with clear suspicion of EMP from 2006 to 2015 were analysed retrospectively...
May 15, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29756111/glomus-tumor-of-the-stomach
#3
Pelin Yıldız, Zuhal Gücin, Dilek Sema Arıcı, Fatma Ümit Malya, Birol Baysal
Glomus tumor is a rare benign mesenchymal neoplasm derived from the glomus body, an arteriovenous shunt mainly located in dermis and subcutis. The most common localization of this tumor is extremities, especially nailbed. Glomus tumor in the gastrointestinal system is a rare condition. Here we report a gastric glomus tumor to raise awareness of this tumor and show the difficulties in the diagnosis.
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29741203/peptide-receptor-radionuclide-therapy-for-advanced-gastroenteropancreatic-neuroendocrine-tumors-from-oncology-perspective
#4
Agnieszka Kolasińska-Ćwikła, Anna Łowczak, Katarzyna Maciejkiewicz Maciejkiewicz, Jarosław Bogdan Ćwikła
Peptide Receptor Radionuclide Therapy (PRRT) is a form of molecular targeted therapy which is performed by using a small peptide (somatostatin analogue - SSA) that is coupled with a radionuclide beta emitting radiation. PRRT is a nuclear medicine for the systemic treatment of non-resectable, metastasized well/moderately differentiated, neuroendocrine tumours (NET) with overexpression of somatostatin receptor. These types of tumours include gastroenteropancreatic neoplasm (GEP-NENs), e.g. arising from the small bowel (often called carcinoid tumours), the pancreas, duodenum or stomach, but also from the large bowel or the lung and many other tissues (so called diffuse neuroendocrine system)...
2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29740725/a-case-of-mixed-adenoneuroendocrine-carcinoma-manec-arising-in-barrett-s-esophagus-literature-and-review
#5
Tetsuro Kawazoe, Hiroshi Saeki, Keitaro Edahiro, Shotaro Korehisa, Daisuke Taniguchi, Kensuke Kudou, Ryota Nakanishi, Nobuhide Kubo, Koji Ando, Yuichiro Nakashima, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara
BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is defined as a neoplasm composed of both exocrine and endocrine carcinomas, each comprising at least 30% of the tumor. MANEC can occur in various organs of the gastrointestinal tract, including the esophagus, stomach, and colon. We herein provide the first case report of surgically resected MANEC arising in Barrett's esophagus (BE). CASE PRESENTATION: A 70-year-old man presenting with abdominal pain was referred to our hospital...
May 8, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29732153/long-term-disease-free-survival-of-gastric-mixed-adenoneuroendocrine-carcinoma-treated-with-multimodality-therapy-a-case-report
#6
Guangjian Yang, Dan Li, Fangchao Zheng, Lin Yang
Gastric mixed adenoneuroendocrine carcinoma, a rare malignant type of stomach tumor, is composed of components of adenocarcinoma and neuroendocrine tumor. This type of neoplasm usually has a poor prognosis since both components are malignant. A 65-year-old male presented with norexia, epigastric distention, abdominal and lumbar pain. Contrast computed tomography scan of the abdomen verified multiple lesions merged into a large mass. Histolopathological examination of the specimen from digestive endoscopy was verified to be gastric mixed adenoneuroendocrine carcinoma...
May 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29722342/gastric-cancer-screening-by-combined-determination-of-serum-helicobacter-pylori-antibody-and-pepsinogen-concentrations-abc-method-for-gastric-cancer-screening
#7
REVIEW
Xian-Zhe Chen, Cheng-Zhi Huang, Wei-Xian Hu, Ying Liu, Xue-Qing Yao
Objective: Gastroscopy combined with gastric mucosa biopsies is currently regarded as a gold standard for diagnosis of gastric cancer. However, its application is restricted in clinical practice due to its invasive property. A new noninvasive population screening process combining the assay of anti-Helicobacter pylori antibody and serum pepsinogen (PG) (ABC method) is adopted to recognize the high-risk patients for further endoscopy examination, avoiding the unnecessary gastroscopy for most population and saving the cost consumption for mass screening annually...
May 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29716579/laterally-spreading-tumour-of-the-distal-stomach-a-case-report
#8
Samiullah Khan, Lan-Ping Zhu, Yujie Zhang, Xin Chen, Bang-Mao Wang
BACKGROUND: Laterally spreading tumours (LSTs) are superficial neoplasms that usually extend laterally along the intra-luminal wall of the gastrointestinal tract. Recently, the incidence of LSTs in the colorectal mucosa has greatly increased. However, LSTs in the stomach are exceedingly rare and have never been previously reported. CASE PRESENTATION: Here, we report a 69-year-old male with epigastric pain and a gastric LST 6 cm in diameter located in the distal stomach and grossly extended into the duodenal bulb...
May 2, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29675587/a-case-of-gastric-neuroendocrine-neoplasm-with-mixed-grade-a-distinct-type-of-high-grade-well-differentiated-neuroendocrine-neoplasm
#9
Elia Guadagno, Gaetano Luglio, Alessandro Iacobelli, Giorgio Borrelli, Antonio Castaldi, Gaetano De Rosa, Marialaura Del Basso De Caro
Grade 3 neuroendocrine tumor (NET G3) is a rare new entity that has recently been introduced in the classification of neuroendocrine neoplasms of the pancreas. It is a well-differentiated form, with a high proliferative activity (Ki67 > 20%), and it represents a category whose prognosis is intermediate between NET G2 and poorly differentiated neuroendocrine carcinoma (NEC G3). In sites other than the pancreas, this new category is by far less coded. Herein is reported a case of NET G3 of the stomach, the 13th described in literature...
April 19, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29658052/reduced-%C3%AE-glcnac-glycosylation-on-gastric-gland-mucin-is-a-biomarker-of-malignant-potential-for-gastric-cancer-barrett-s-adenocarcinoma-and-pancreatic-cancer
#10
REVIEW
Kazuhiro Yamanoi, Jun Nakayama
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient in A4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type adenocarcinoma, even if not infected by H...
April 16, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29650941/-a-case-of-an-intraductal-papillary-mucinous-neoplasm-which-rapidly-worsened-and-penetrated-into-the-stomach-and-the-transverse-colon
#11
Akira Sogawa, Kei Nakamura, Tomoyuki Nagata, Satoshi Mochizuki, Yuen Nakase, Shozo Kitai, Seishirou Inaba, Keiji Shimada
We report a case of a 71-year-old woman.She visited our hospital with a complaint of high fever and abdominal distention. She has been pointed out intraductal papillary mucinous neoplasm(IPMN)4 years ago.Abdominal CT showed cystic legion, 80mm in diameter, on the pancreas.The lesion was unclear at the boundary between the main pancreatic duct and in contact with the stomach, transverse colon.Upper endoscopic and colonoscopic examination revealed the exhaustion image from the intestional tract but not pointed out the malignant findings...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650930/-a-case-of-early-gastric-cancer-with-multiple-lymph-node-metastases-revealed-by-additional-surgical-resection-after-esd
#12
Yoshitaka Nakamura, Masayuki Yubakami, Yutaka Kondo, Yukihisa Nishimura, Momoko Todo, Kiyoto Atsuji, Akihiro Yamaguchi, Naoki Kakihara, Osamu Ikawa, Hiroki Taniguchi
A 74-year-old man was referred to our hospital for further investigation of a cystic lesion in the pancreatic body, which had been detected by ultrasonography at a local hospital. He was diagnosed as intraductal papillary mucinous neoplasm(IPMN) and further preoperative examinations were conducted. Upper gastrointestinal endoscopy demonstrated a type 0-II c tumor of the greater curvature in the upper third of the stomach. Endoscopic ultrasonography showed no sign of submucosal invasion. Endoscopic submucosal dissection(ESD)was carried out and pathological examination of a specimen revealed well differentiated adenocarcinoma with submucosal invasion, which fulfilled the indication for additional gastrectomy with lymph node dissection...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650912/-two-cases-of-neuroendocrine-carcinoma-of-the-non-ampullary-duodenum
#13
Miho Watanabe, Shigeru Fujisaki, Motoi Takashina, Ryouichi Tomita, Kenichi Sakurai, Tadatoshi Takayama
Here we report 2 cases of neuroendocrine carcinoma(NEC)of the non-ampullary duodenum which is extremely rare neoplasm. Case 1: A 76-year-old man had a type 2 duodenal carcinoma with a 3 cm-sized lymph node metastasis. Duodenal resection with subpyloric lymph nodes dissection and Roux-en-Y reconstruction were performed. The histopathological diagnosis was NEC of the duodenal bulb after surgery(pT3pN1M0, stage III A, UICC 7th edition). The patient died of chronic heart failure 10 years and 3 months after the surgery...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29621878/characteristics-of-synchronous-and-metachronous-multiple-gastric-tumors-after-endoscopic-submucosal-dissection-of-early-gastric-neoplasm
#14
Hyun Jik Lee, Yoo Jin Lee, Ju Yup Lee, Eun Soo Kim, Woo Jin Chung, Byoung Kuk Jang, Kyung Sik Park, Jae Seok Hwang, Kwang Bum Cho
Background/Aims: Endoscopic submucosal dissection (ESD) has been widely accepted as a method of treatment of early gastric tumor. This study aimed to identify the incidence and characteristics of multiple gastric tumors after ESD. Methods: Patients with early gastric tumors who were treated by ESD from January 2004 to June 2012 and followed up with endoscopic examination periodically for at least 1 year were enrolled. All multiple gastric lesions were subsequently treated with ESD and the medical records of the patients were retrospectively reviewed...
April 6, 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29615296/reexamining-post-transplant-lymphoproliferative-disorders-newly-recognized-and-enigmatic-types
#15
REVIEW
Nadine Aguilera, Alejandro A Gru
Post-transplant lymphoproliferative disorders (PTLD) are a known risk for both solid organ transplant and stem cell transplant recipients. Overall transplant recipients have a six fold increase in risk for developing any kind of non-Hodgkin lymphoma and PTLDs occur in up to 10% of SOT recipients. Several new entities have been accepted or renamed in the 2018 update of the WHO classification of tumors of hematopoietic and lymphoid neoplasms, including florid follicular hyperplasia and extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT-lymphoma) (excluding common locations such as stomach and salivary gland)...
March 3, 2018: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/29553226/a-rare-case-of-gastric-fistulization-of-a-main-duct-ipmn-a-case-report
#16
Pablo Cortegoso Valdivia, Mauro Bruno, Silvia Gaia, Giorgio M Saracco, Claudio DE Angelis
We report a rare case of gastric fistulization in a patient with main-duct (MD) intraductal papillary mucinous neoplasm (IPMN). Fistulization to adjacent organs is a rare complication of this disease, mainly affecting the duodenum; the fact that the stomach was the only organ involved makes this case even more peculiar. The diagnosis of the fistula was made after examination with Endoscopic Ultrasound (EUS), since a previous computed tomography (CT) scan wasn't able to detect it.
March 16, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29549680/bowel-wall-thickening-inquire-or-not-inquire-our-guidelines
#17
D Iadicola, P De Marco, S Bonventre, E M Grutta, G Barletta, L Licari, G Gulotta
INTRODUCTION: Bowel wall thickening is not an uncommon finding among patient undergoing abdomen CT scan. It may be caused by neoplastic, inflammatory, infectious or ischaemic conditions but also be a normal variant. Although specific radiologic patterns may direct to a precise diagnosis, occasionally misidentification may occur. Thus, in the absence of guidelines, further and not always needed diagnostic procedures (colonoscopy, esophagogastroduodenoscopy or capsule endoscopy) are performed...
January 2018: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29528821/lynch-syndrome-genomics-update-and-imaging-review
#18
Veronica L Cox, Anas A Saeed Bamashmos, Wai Chin Foo, Shiva Gupta, Sireesha Yedururi, Naveen Garg, Hyunseon Christine Kang
Lynch syndrome is the most common hereditary cancer syndrome, the most common cause of heritable colorectal cancer, and the only known heritable cause of endometrial cancer. Other cancers associated with Lynch syndrome include cancers of the ovary, stomach, urothelial tract, and small bowel, and less frequently, cancers of the brain, biliary tract, pancreas, and prostate. The oncogenic tendency of Lynch syndrome stems from a set of genomic alterations of mismatch repair proteins. Defunct mismatch repair proteins cause unusually high instability of regions of the genome called microsatellites...
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29527619/how-should-incidental-nen-of-the-pancreas-and-gastrointestinal-tract-be-followed
#19
REVIEW
Riccardo Ariotti, Stefano Partelli, Francesca Muffatti, Valentina Andreasi, Francesca Della Sala, Massimo Falconi
Neuroendocrine gastro-entero-pancreatic neoplasms (GEP-NENs) constitute a heterogeneous group of tumors, whose incidence has increased over the years. The most frequent site for primary disease is the stomach followed by small and large intestine, and pancreas. In the last decade, a dramatic growing in the incidence of small, incidental GEP-NENs has been recorded. In parallel, an increasing attitude toward more conservative approaches instead of surgical management has being widely spreading. This is particularly true for small, asymptomatic, pancreatic NEN as for these tumor forms an active surveillance has proven to be safe and feasible...
March 12, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29511413/a-rare-cause-of-abdominal-pain-and-mass-in-an-18-year-old-patient-a-diagnostic-dilemma
#20
Hassan Tariq, Muhammad Umar Kamal, Vamshidhar Vootla, Mohamed ElZaeedi, Masooma Niazi, Brian Gilchrist, Ariyo Ihimoyan, Anil Dev, Sridhar Chilimuri
We present a case of an 18-year-old male who presented with complains of abdominal pain, nausea and vomiting for 2 years. An esophagogastroduodenoscopy (EGD) revealed a 3 mm nodule on the lesser curvature of the stomach and prominent gastric folds. Biopsy of the nodule revealed a well-differentiated neuroendocrine tumor (NET) in lamina prop with focal extension into muscularis mucosa consistent with a gastric carcinoid. Tumor cells stained with neuron-specific enolase (NSE), chromogranin and synaptophysin only...
February 2018: Gastroenterology Research
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