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REVIEW
Vikramaditya Dumpa, Indirapriya Avulakunta, Vineet Bhandari
INTRODUCTION: Advances in neonatal care have made possible the increased survival of extremely preterm infants. Even though there is widespread recognition of the harmful effects of mechanical ventilation on the developing lung, its use has become imperative in the management of micro-/nano-preemies. There is an increased emphasis on the use of less-invasive approaches such as minimally invasive surfactant therapy and non-invasive ventilation that have been proven to result in improved outcomes...
February 2023: Expert Review of Respiratory Medicine
#22
JOURNAL ARTICLE
Manuela Cucerea, Mihaela Moscalu, Elena Moldovan, Reka Santa, Zsuzsanna Gall, Laura Mihaela Suciu, Marta Simon
BACKGROUND: It is currently considered that early initiation of nasal continuous positive airway pressure, using a less invasive exogenous surfactant administration and avoiding mechanical ventilation as much as possible to minimize lung damage, may reduce mortality and/or the risk of morbidities in preterm infants. The aim of our study was to quantify our experience and compare different strategies of surfactant administration, to investigate which method is associated with less morbidity...
February 3, 2023: Healthcare (Basel, Switzerland)
#23
JOURNAL ARTICLE
David Guevorkian, Eric Cavatorta, Anne Rassart, Serge Vanden Eijnden, Agnese Vicari, Ismail Sanoussi, Nathalie Jacques, Yoann Marechal
INTRODUCTION: Currently, INSURE (Intubation-Surfactant-Extubation) and LISA (Less Invasive Surfactant Administration) are two recommended techniques for surfactant delivery to newborns with respiratory distress syndrome. The aim of this study was to evaluate the feasibility, safety, tolerability of a new technique of surfactant administration in newborns without anesthesia or laryngoscopy: Fiberscope Assisted Surfactant Therapy (FAST). METHODS: This monocentric, prospective, nonrandomized, pilot feasibility study was conducted from January to December 2021...
2022: Neonatology
#24
JOURNAL ARTICLE
Shaily Brahmbhatt, Brooke Read, Orlando Da Silva, Soume Bhattacharya
Introduction: Minimally invasive surfactant therapy (MIST) can be used to treat neonatal respiratory distress syndrome in neonatal intensive care units (NICUs). Clinical and institutional variances in MIST utilization persist globally with little published research regarding MIST utilization in Canada. Therefore, the objective of this study was to survey MIST utilization in NICUs in Canada. Methods: An online survey was emailed to the 33 participating centres of Canadian Neonatal NetworkTM (CNN) Evidence-based Practice for Improving Quality (EPIQ) Lung Health Group (LHG)...
2022: Canadian Journal of Respiratory Therapy: CJRT
#25
EDITORIAL
Aila Akosua Kattner
In this issue of the Biomedical Journal the reader is provided with an insight into the latest observations and advances in acute kidney injury as well as chronic kidney disease. The current SARS-CoV-2 variants are reviewed, and the role of long non-coding RNA in HIV therapy is explored. Furthermore, the potential of metabolomics as means to diagnose multiple sclerosis as well as tuberculosis is presented. Other topics of this issue include the restoration of the spermatogonial stem cell niche; atherosclerosis and the use of improved ultrasound images; and the effect of transcranial magnetic stimulation in patients with autism spectrum disorder...
August 6, 2022: Biomedical Journal
#26
JOURNAL ARTICLE
Seungmin Noh, Sungwoong Jeon, Eunhee Kim, Untaek Oh, Danbi Park, Sun Hwa Park, Sung Won Kim, Salvador Pané, Bradley J Nelson, Jin-Young Kim, Hongsoo Choi
A great deal of research has focused on small-scale robots for biomedical applications and minimally invasive delivery of therapeutics (e.g., cells, drugs, and genes) to a target area. Conventional fabrication methods, such as two-photon polymerization, can be used to build sophisticated micro- and nanorobots, but the long fabrication cycle for a single microrobot has limited its practical use. This study proposes a biodegradable spherical gelatin methacrylate (GelMA) microrobot for mass production in a microfluidic channel...
June 2022: Small
#27
COMMENT
Abdul Razak
No abstract text is available yet for this article.
April 26, 2022: JAMA
#28
COMMENT
Pengxiang Zhou, Tongyan Han
No abstract text is available yet for this article.
April 26, 2022: JAMA
#29
COMMENT
Peter A Dargaville, John B Carlin, Peter G Davis
No abstract text is available yet for this article.
April 26, 2022: JAMA
#30
REVIEW
I-Ling Chen, Hsiu-Lin Chen
Respiratory distress syndrome (RDS) is the major cause of respiratory failure in preterm infants due to immature lung development and surfactant deficiency. Although the concepts and methods of managing respiratory problems in neonates have changed continuously, determining appropriate respiratory treatment with minimal ventilation-induced lung injury and complications is crucially important. This review summarizes neonatal respiratory therapy's advances and available strategies (i.e., exogenous surfactant therapy, noninvasive ventilation, and different ventilation modes), focusing on RDS management...
July 2022: Pediatrics and Neonatology
#31
JOURNAL ARTICLE
Karthik Pushpavanam, Subhadeep Dutta, Sahil Inamdar, Tomasz Bista, Thaddeus Sokolowski, Alek Rapchak, Amir Sadeghi, Stephen Sapareto, Kaushal Rege
Modern radiation therapy workflow involves complex processes intended to maximize the radiation dose delivered to tumors while simultaneously minimizing excess radiation to normal tissues. Safe and accurate delivery of radiation doses is critical to the successful execution of these treatment plans and effective treatment outcomes. Given extensive differences in existing dosimeters, the choice of devices and technologies for detecting biologically relevant doses of radiation has to be made judiciously, taking into account anatomical considerations and modality of treatment (invasive, e...
March 22, 2022: ACS Applied Materials & Interfaces
#32
REVIEW
Nayef Chahin, Henry J Rozycki
The provision of exogenous surfactant to premature infants with respiratory distress syndrome has revolutionized the way we care for these patients, significantly improving survival and decreasing morbidity. Currently, the Intubate-SURfactant-Extubate (INSURE) to non-invasive ventilation method remains the standard method for surfactant delivery in the United States. However, the INSURE method requires intubation via direct visualization with a laryngoscope and possible need for sedation. Both carry significant risk to the patients, prompting the development of less invasive ways of safely and efficaciously providing surfactant to newborn infants...
September 2022: Paediatric Respiratory Reviews
#33
RANDOMIZED CONTROLLED TRIAL
Peter A Dargaville, C Omar F Kamlin, Francesca Orsini, Xiaofang Wang, Antonio G De Paoli, H Gozde Kanmaz Kutman, Merih Cetinkaya, Lilijana Kornhauser-Cerar, Matthew Derrick, Hilal Özkan, Christian V Hulzebos, Georg M Schmölzer, Ajit Aiyappan, Brigitte Lemyre, Sheree Kuo, Victor S Rajadurai, Joyce O'Shea, Manoj Biniwale, Rangasamy Ramanathan, Alla Kushnir, David Bader, Mark R Thomas, Mallinath Chakraborty, Mariam J Buksh, Risha Bhatia, Carol L Sullivan, Eric S Shinwell, Amanda Dyson, David P Barker, Amir Kugelman, Tim J Donovan, Markus K Tauscher, Vadivelam Murthy, Sanoj K M Ali, Pete Yossuck, Howard W Clark, Roger F Soll, John B Carlin, Peter G Davis
IMPORTANCE: The benefits of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome are uncertain. OBJECTIVE: To examine the effect of selective application of MIST at a low fraction of inspired oxygen threshold on survival without bronchopulmonary dysplasia (BPD). DESIGN, SETTING, AND PARTICIPANTS: Randomized clinical trial including 485 preterm infants with a gestational age of 25 to 28 weeks who were supported with continuous positive airway pressure (CPAP) and required a fraction of inspired oxygen of 0...
December 28, 2021: JAMA
#34
JOURNAL ARTICLE
Tetsuya Isayama
No abstract text is available yet for this article.
December 28, 2021: JAMA
#35
JOURNAL ARTICLE
Talal Altamimi, Brooke Read, Orlando da Silva, Soume Bhattacharya
BACKGROUND: The use of less invasive surfactant administration (LISA)/minimally invasive surfactant therapy (MIST) has increased due to its potential advantage over traditional surfactant delivery methods through an endotracheal tube. Known complications for this procedure include failure of the first attempt at insertion, desaturation, and bradycardia. To the best of our knowledge, this is the first reported case of pneumomediastinum and subcutaneous emphysema following LISA. CASE PRESENTATION: A preterm newborn born at 27 weeks of gestation presented with respiratory distress syndrome requiring surfactant replacement...
November 10, 2021: BMC Pediatrics
#36
JOURNAL ARTICLE
Soume Bhattacharya, Brooke Read, Michael Miller, Orlando da Silva
OBJECTIVE: Surfactant delivery via a thin endotracheal catheter during spontaneous breathing; a technique called minimally invasive surfactant therapy (MIST) is an alternative to intubation and surfactant administration. Procedural details among different centers vary, with marked differences in the choice of catheter to instill surfactant. Studies report use of feeding catheters, multiaccess suction catheters, vascular catheters, and more recently custom-built catheters for this purpose...
September 24, 2021: American Journal of Perinatology
#37
JOURNAL ARTICLE
Stacey Chi-Yan Lo, Risha Bhatia, Calum T Roberts
INTRODUCTION: Exposure to mechanical ventilation (MV) is a risk factor for bronchopulmonary dysplasia (BPD) in very preterm infants (VPTIs). We assessed the impact of a quality improvement (QI) bundle in VPTIs (<32 week gestation) on exposure to MV. METHODS: We introduced a QI bundle consisting of deferred cord clamping (DCC), nasal bubble continuous positive airway pressure (bCPAP) in the delivery room (DR), and minimally invasive surfactant therapy (MIST). We compared respiratory outcomes and neonatal morbidity in historical pre-QI (July-December 2017) and prospective post-QI (February-July 2019) cohorts (QICs) of VPTIs...
2021: Neonatology
#38
JOURNAL ARTICLE
Michael Wagner, Maria C den Boer, Sophie Jansen, Peter Groepel, Remco Visser, Ruben S G M Witlox, Vincent Bekker, Enrico Lopriore, Angelika Berger, Arjan B Te Pas
OBJECTIVE: The aim of this study was to determine the experience with, and the feasibility of, point-of-view video recordings using eye-tracking glasses for training and reviewing neonatal interventions during the COVID-19 pandemic. DESIGN: Observational prospective single-centre study. SETTING: Neonatal intensive care unit at the Leiden University Medical Center. PARTICIPANTS: All local neonatal healthcare providers...
August 19, 2021: Archives of Disease in Childhood. Fetal and Neonatal Edition
#39
JOURNAL ARTICLE
Steven M Conlon, Allison Osborne, Julie Bodie, Jaime Marasch, Rita M Ryan, Tara Glenn
Less-invasive surfactant administration (LISA), a newer technique of delivering surfactant via a thin catheter, avoids mechanical ventilation. LISA has been widely adopted in Europe but less so in the US. Our goal was to increase the percentage of surfactant delivered via LISA from 0% to 51% by 12/2020. Project planning and literature review started 12/2019, and included a standardized equipment kit and simulation training sessions. We began Plan-Do-Study-Act (PDSA) cycles in 6/2020. Initial exclusions for LISA were gestational age (GA) <28 weeks (w) or ≥36 w, intubation in the delivery room, or PCO2 >70 if known; GA exclusion is now <25 w...
July 7, 2021: Children
#40
JOURNAL ARTICLE
Mohammad Kazem Sabzehei, Behnaz Basiri, Maryam Shokouhi, Sajad Ghahremani, Ali Moradi
BACKGROUND: Respiratory distress syndrome (RDS) is a common cause of hospitalization and death in preterm infants who require surfactant treatment and respiratory support. PURPOSE: This study aimed to compare the clinical outcomes of minimally invasive surfactant therapy (MIST) and the INtubation, SURfactant administration, and Extubation (INSURE) technique in preterm infants with RDS. METHODS: In this clinical trial, 112 preterm infants born at 28-36 weeks of gestation and diagnosed with RDS randomly received 200-mg/kg surfactant by MIST or the INSURE method...
April 2022: Clinical and experimental pediatrics
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