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JOURNAL ARTICLE
Tamara Jahmani, Michael R Miller, Orlando da Silva, Soume Bhattacharya
UNLABELLED: Minimally invasive surfactant therapy (MIST) has emerged as a preferred method of surfactant delivery. Pioneers of this technique have described the use of direct laryngoscopy (DL) for MIST. With the increasing application of video laryngoscopy (VL) for neonatal airway management, it is speculated that MIST techniques can be adapted for use with VL. OBJECTIVE: To compare procedural success, operator ease of use, and complication of MIST using VL vs. MIST using DL...
March 9, 2024: Biomedicines
#2
LETTER
Kai Liu, Yuan Shi
No abstract text is available yet for this article.
January 23, 2024: JAMA
#3
JOURNAL ARTICLE
Shen Ko, Shin-Hwa Tsai, Nin-Chieh Hsu
No abstract text is available yet for this article.
January 23, 2024: JAMA
#4
LETTER
Peter A Dargaville, John B Carlin, Peter G Davis
No abstract text is available yet for this article.
January 23, 2024: JAMA
#5
JOURNAL ARTICLE
Namrata V Sawant, Samuel S Chang, Krutika A Pandit, Prachi Khekare, W Randolph Warner, Philippe E Zimmern, Nicole J De Nisco
Management of urinary tract infection (UTI) in postmenopausal women can be challenging. The recent rise in resistance to most of the available oral antibiotic options together with high recurrence rate in postmenopausal women has further complicated treatment of UTI. As such, intravesical instillations of antibiotics like gentamicin are being investigated as an alternative to oral antibiotic therapies. This study evaluates the efficacy of the candidate intravesical therapeutic VesiX, a solution containing the cationic detergent Cetylpyridinium chloride, against a broad range of uropathogenic bacterial species clinically isolated from postmenopausal women with recurrent UTI (rUTI)...
January 19, 2024: Microbiology Spectrum
#6
JOURNAL ARTICLE
Harun O Owuor, Victor Akelo, Florence Murila, Dickens Onyango, Magdalene Kuria, Emily Rogena, Gunturu Revathi, Paul Mitei, Solomon Sava, Joyce Were, Aggrey Igunza, Sammy Khagayi, Emily Zielinski-Gutierrez, Sarah Hawi, Dickson Gethi, Jennifer R Verani, Clayton Onyango, Dianna M Blau, Beth A Tippett Barr
Objectives. To describe RDS in neonatal deaths at the CHAMPS-Kenya site between 2017 and 2021. Methods. We included 165 neonatal deaths whose their Causes of death (COD) were determined by a panel of experts using data from post-mortem conducted through minimally invasive tissue specimen testing, clinical records, and verbal autopsy. Results. Twenty-six percent (43/165) of neonatal deaths were attributable to RDS. Most cases occurred in low birthweight and preterm neonates. From these cases, less than half of the hospitalizations were diagnosed with RDS before death, and essential diagnostic tests were not performed in most cases...
2023: Global Pediatric Health
#7
JOURNAL ARTICLE
Yuto Kubo, Takayuki Yasui, Yuko Matsuda, Yasutomo Takahashi, Kotaro Yamashita, Takuro Saito, Koji Tanaka, Tomoki Makino, Tsuyoshi Takahashi, Yukinori Kurokawa, Hidetoshi Eguchi, Yuichiro Doki, Kiyokazu Nakajima
BACKGROUND: Fogging and staining of a laparoscope lens negatively impact surgical visualization. We hypothesized that the disposable hot pack could not only warm but also clean laparoscopes. Hence, this study verified and developed the disposable hot pack with anti-fogging and cleaning function. MATERIAL AND METHODS: The laparoscope was inserted into a swine abdominal cavity for five minutes. Then, the laparoscopic tip was heated with 65 °C saline or the folded disposable hot pack with nonwoven fabric coated surfactant for ten seconds ( n = 15)...
December 4, 2023: Minimally Invasive Therapy & Allied Technologies: MITAT
#8
REVIEW
Angela Kribs, Kari D Roberts, Daniele Trevisanuto, Colm O' Donnell, Peter A Dargaville
Non-invasive modes of respiratory support have been shown to be the preferable way of primary respiratory support of preterm infants with respiratory distress syndrome (RDS). The avoidance of invasive mechanical ventilation can be beneficial for preterm infants in reduction of morbidity and even mortality. However, it is well-established that some infants managed with non-invasive respiratory support from the outset have symptomatic RDS to a degree that warrants surfactant administration. Infants for whom non-invasive respiratory support ultimately fails are prone to adverse outcomes, occurring at a frequency on par with the group intubated primarily...
December 2023: Seminars in Fetal & Neonatal Medicine
#9
RANDOMIZED CONTROLLED TRIAL
Kate L Francis, Christopher J D McKinlay, C Omar F Kamlin, Jeanie L Y Cheong, Peter A Dargaville, Jennifer A Dawson, Lex W Doyle, Susan E Jacobs, Peter G Davis, Susan M Donath, Brett J Manley
BACKGROUND: Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks' gestation and is associated with an increased risk of adverse neurodevelopmental and respiratory outcomes in childhood. Effective and safe prophylactic therapies for BPD are urgently required. Systemic corticosteroids reduce rates of BPD in the short term but are associated with poorer neurodevelopmental outcomes if given to ventilated infants in the first week after birth...
November 6, 2023: Trials
#10
REVIEW
Greta Sibrecht, Colby R Kearl, Franciszek Borys, Mihai Morariu, Matteo Bruschettini, Roger Soll
BACKGROUND: Administration of various exogenous surfactant preparations has been shown to decrease lung injury and pneumothorax and improve survival in very preterm infants with respiratory distress syndrome (RDS). There is no consensus on the threshold for surfactant administration, to allow timely intervention and avoid over-treatment, also considering the invasiveness of the procedure and its cost. Rapid tests for lung maturity, which include the click test, lamellar body counts and stable microbubble test, might guide the identification of those infants needing surfactant administration...
October 26, 2023: Cochrane Database of Systematic Reviews
#11
JOURNAL ARTICLE
Rong Zhou, Tao Xiong, Jun Tang, Yi Huang, Wenli Liu, Jun Zhu, Chao Chen, Lingyue Gong, Ke Tian, Aoyu Wang, Dezhi Mu
BACKGROUND: Health problems in neonates with gestational age (GA) ≥ 32 weeks remain a major medical concern. Respiratory distress (RD) is one of the common reasons for admission of neonates with GA ≥ 32 weeks. Noninvasive ventilation (NIV) represents a crucial approach to treat RD, and currently, the most used NIV modes in neonatal intensive care unit include high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), and nasal intermittent positive pressure ventilation...
October 6, 2023: Trials
#12
JOURNAL ARTICLE
Talib Al Harthy, Michael R Miller, Orlando daSilva, Soume Bhattacharya
BACKGROUND: Minimally invasive surfactant therapy (MIST), a method of surfactant delivery via a thin catheter during spontaneous breathing, is an increasingly popular alternative to intubation and surfactant administration. Recently, purpose-built catheters for MIST received regulatory approval in Canada and became available for use. However, procedural success and user experience with such catheters have not been described. METHODS: This retrospective cohort study included neonates who received MIST using purpose-built catheters between January 1, 2021, and March 31, 2022...
2023: Canadian Journal of Respiratory Therapy: CJRT
#13
JOURNAL ARTICLE
Sanghee Lee, Moon Jae Chung, Minji Ahn, Hyun Jin Park, Eun Kyung Wang, Taeeun Guon, Hyun Jung Kee, Cheol Ryong Ku, Kun Na
Duodenal ablation improves glycaemic control and weight loss, so it has been applied using hydrothermal catheters in obese and type 2 diabetes patients, indicating similar mechanisms and therapeutic effects as bariatric surgeries. Endoscopic photodynamic therapy is an innovative procedure that easily accessible to endocrine or gastrointestinal organs, so it is critical for the sprayed photosensitizer (PS) to long-term interact with target tissues for enhancing its effects. Surfactant-like PS was more stable in a wide range of pH and 2...
September 23, 2023: Biomaterials
#14
JOURNAL ARTICLE
Iuri Corsini, Maria Beatrice Lenzi, Martina Ciarcià, Federico Matina, Enrico Petoello, Alice Iride Flore, Silvia Nogara, Antonella Gangemi, Monica Fusco, Letizia Capasso, Francesco Raimondi, Javier Rodriguez-Fanjul, Carlo Dani, Benjamim Ficial
Lung ultrasound (LU) has emerged as the imaging technique of choice for the assessment of neonates with respiratory distress syndrome (RDS) at the bedside. Scoring systems were developed to quantify RDS severity and to predict the need for surfactant administration. There is no data on the comparison of the three main LU scores (LUS) proposed by Brat, Raimondi and Rodriguez-Fanjul. Moreover, there is not enough evidence to recommend which score and which cut-off has the best ability to predict surfactant need...
September 23, 2023: European Journal of Pediatrics
#15
RANDOMIZED CONTROLLED TRIAL
Peter A Dargaville, C Omar F Kamlin, Francesca Orsini, Xiaofang Wang, Antonio G De Paoli, H Gozde Kanmaz Kutman, Merih Cetinkaya, Lilijana Kornhauser-Cerar, Matthew Derrick, Hilal Özkan, Christian V Hulzebos, Georg M Schmölzer, Ajit Aiyappan, Brigitte Lemyre, Sheree Kuo, Victor S Rajadurai, Joyce O'Shea, Manoj Biniwale, Rangasamy Ramanathan, Alla Kushnir, David Bader, Mark R Thomas, Mallinath Chakraborty, Mariam J Buksh, Risha Bhatia, Carol L Sullivan, Eric S Shinwell, Amanda Dyson, David P Barker, Amir Kugelman, Tim J Donovan, Kevin C W Goss, Markus K Tauscher, Vadivelam Murthy, Sanoj K M Ali, Howard W Clark, Roger F Soll, Samantha Johnson, Jeanie L Y Cheong, John B Carlin, Peter G Davis
IMPORTANCE: The long-term effects of surfactant administration via a thin catheter (minimally invasive surfactant therapy [MIST]) in preterm infants with respiratory distress syndrome remain to be definitively clarified. OBJECTIVE: To examine the effect of MIST on death or neurodevelopmental disability (NDD) at 2 years' corrected age. DESIGN, SETTING, AND PARTICIPANTS: Follow-up study of a randomized clinical trial with blinding of clinicians and outcome assessors conducted in 33 tertiary-level neonatal intensive care units in 11 countries...
September 19, 2023: JAMA
#16
JOURNAL ARTICLE
Susanta Pahari, Eusondia Arnett, Jan Simper, Abul Azad, Israel Guerrero-Arguero, Chengjin Ye, Hao Zhang, Hong Cai, Yufeng Wang, Zhao Lai, Natalie Jarvis, Miranda Lumbreras, Diego Jose Maselli, Jay Peters, Jordi B Torrelles, Luis Martinez-Sobrido, Larry S Schlesinger
Alveolar macrophages (AMs) are unique lung resident cells that contact airborne pathogens and environmental particulates. The contribution of human AMs (HAMs) to pulmonary diseases remains poorly understood due to the difficulty in accessing them from human donors and their rapid phenotypic change during in vitro culture. Thus, there remains an unmet need for cost-effective methods for generating and/or differentiating primary cells into a HAM phenotype, particularly important for translational and clinical studies...
June 8, 2023: MBio
#17
JOURNAL ARTICLE
Brett J Manley, C Omar F Kamlin, Susan Donath, Li Huang, Pita Birch, Jeanie L Y Cheong, Peter A Dargaville, Jennifer A Dawson, Lex W Doyle, Susan E Jacobs, Rodney Wilson, Peter G Davis, Christopher J D McKinlay
BACKGROUND: Bronchopulmonary dysplasia (BPD), an inflammatory-mediated chronic lung disease, is common in extremely preterm infants born before 28 weeks' gestation and is associated with an increased risk of adverse neurodevelopmental and respiratory outcomes in childhood. Effective and safe prophylactic therapies for BPD are urgently required. Systemic corticosteroids reduce rates of BPD in the short-term but are associated with poorer neurodevelopmental outcomes if given to ventilated infants in the first week after birth...
May 9, 2023: Trials
#18
JOURNAL ARTICLE
Elizabeth Reid, Omar F Kamlin, Francesca Orsini, Antonio G De Paoli, Howard W Clark, Roger F Soll, John B Carlin, Peter G Davis, Peter A Dargaville
BACKGROUND: Blinding of treatment allocation from treating clinicians in neonatal randomised controlled trials can minimise performance bias, but its effectiveness is rarely assessed. METHODS: To examine the effectiveness of blinding a procedural intervention from treating clinicians in a multicentre randomised controlled trial of minimally invasive surfactant therapy versus sham treatment in preterm infants of gestation 25-28 weeks with respiratory distress syndrome...
May 5, 2023: Clinical Trials: Journal of the Society for Clinical Trials
#19
Susanta Pahari, Eusondia Arnett, Jan Simper, Abul Azad, Israel Guerrero-Arguero, Chengjin Ye, Hao Zhang, Hong Cai, Yufeng Wang, Zhao Lai, Natalie Jarvis, Miranda Lumbreras, Diego Jose Maselli-Caceres, Jay Peters, Jordi B Torrelles, Luis Martinez-Sobrido, Larry S Schlesinger
UNLABELLED: Alveolar macrophages (AMs) are unique lung resident cells that contact airborne pathogens and environmental particulates. The contribution of human AMs (HAM) to pulmonary diseases remains poorly understood due to difficulty in accessing them from human donors and their rapid phenotypic change during in vitro culture. Thus, there remains an unmet need for cost-effective methods for generating and/or differentiating primary cells into a HAM phenotype, particularly important for translational and clinical studies...
April 6, 2023: bioRxiv
#20
JOURNAL ARTICLE
Tejasi Sawant, Swati Manerkar, Saikat Patra, Pavan Kalamdani, Thaslima Kalathingal, Jayashree Mondkar
OBJECTIVE: To evaluate the pain or physiological stress caused during minimally invasive surfactant therapy (MIST) to very preterm neonates. METHODS: In this prospective observational study conducted in a tertiary NICU, very preterm neonates were assessed for pain using Premature Infant Pain Profile-Revised (PIPP-R) score before, during and after MIST. Changes in the heart rate and oxygen saturation were also recorded during the procedure. RESULTS: 23 neonates who received MIST were assessed for pain using PIPP-R...
July 15, 2023: Indian Pediatrics
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