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minimally invasive surfactant therapy

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https://www.readbyqxmd.com/read/27649091/european-consensus-guidelines-on-the-management-of-respiratory-distress-syndrome-2016-update
#1
David G Sweet, Virgilio Carnielli, Gorm Greisen, Mikko Hallman, Eren Ozek, Richard Plavka, Ola Didrik Saugstad, Umberto Simeoni, Christian P Speer, Máximo Vento, Gerard H A Visser, Henry L Halliday
Advances in the management of respiratory distress syndrome (RDS) ensure that clinicians must continue to revise current practice. We report the third update of the European Guidelines for the Management of RDS by a European panel of expert neonatologists including input from an expert perinatal obstetrician based on available literature up to the beginning of 2016. Optimizing the outcome for babies with RDS includes consideration of when to use antenatal steroids, and good obstetric practice includes methods of predicting the risk of preterm delivery and also consideration of whether transfer to a perinatal centre is necessary and safe...
September 21, 2016: Neonatology
https://www.readbyqxmd.com/read/26958689/strategies-of-using-surfactant-results-of-the-first-polish-national-survey-of-daily-practice
#2
Maria Katarzyna Borszewska-Kornacka, Marzena Kostuch, Piotr Korbal, Paweł Krajewski
BACKGROUND: The efficiency of routine practices in the management of neonatal respiratory distress syndrome (RDS) have never been systematically investigated in Poland. OBJECTIVE: To evaluate RDS treatment policies and short-term outcomes in neonatal intensive care units (NICUs). MATERIAL AND METHODS: We retrospectively analyzed medical records of premature neonates ≤ 32 weeks' gestation, diagnosed with RDS in level-2 and level-3 referral centers...
July 2015: Developmental Period Medicine
https://www.readbyqxmd.com/read/26907795/sedation-during-minimal-invasive-surfactant-therapy-in-preterm-infants
#3
Janneke Dekker, Enrico Lopriore, Monique Rijken, Esther Rijntjes-Jacobs, Vivianne Smits-Wintjens, Arjan Te Pas
BACKGROUND: There is no data available whether sedation should be given during minimally invasive surfactant therapy (MIST). OBJECTIVE: To compare the level of comfort of preterm infants receiving sedation versus no sedation for MIST. METHODS: A retrospective study of preterm infants receiving MIST was performed in Leiden University Medical Center in 2014. Sedation (propofol 1 mg/kg) was optional and left to the discretion of the caregiver...
2016: Neonatology
https://www.readbyqxmd.com/read/26724118/effect-of-minimally-invasive-surfactant-therapy-on-lung-volume-and-ventilation-in-preterm-infants
#4
Pauline S van der Burg, Frans H de Jongh, Martijn Miedema, Inez Frerichs, Anton H van Kaam
OBJECTIVE: To assess the changes in (regional) lung volume and gas exchange during minimally invasive surfactant therapy (MIST) in preterm infants with respiratory distress syndrome. STUDY DESIGN: In this prospective observational study, infants requiring a fraction of inspired oxygen (FiO2) ≥ 0.30 during nasal continuous positive airway pressure of 6 cmH2O were eligible for MIST. Surfactant (160-240 mg/kg) was administered in supine position in 1-3 minutes via an umbilical catheter placed 2 cm below the vocal cords...
March 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26553376/nasal-continuous-positive-airway-pressure-versus-nasal-intermittent-positive-pressure-ventilation-within-the-minimally-invasive-surfactant-therapy-approach-in-preterm-infants-a-randomised-controlled-trial
#5
Mehmet Yekta Oncel, Sema Arayici, Nurdan Uras, Evrim Alyamac-Dizdar, Fatma Nur Sari, Sevilay Karahan, Fuat Emre Canpolat, Serife Suna Oguz, Ugur Dilmen
OBJECTIVE: To compare the effectiveness of nasal continuous positive airway pressure (NCPAP) and nasal intermittent positive-pressure ventilation (NIPPV) as the initial respiratory support within the minimally invasive surfactant therapy (MIST) approach in preterm infants with respiratory distress syndrome. DESIGN: Prospective, randomised controlled study. SETTING: Tertiary neonatal intensive care unit. PATIENTS AND INTERVENTIONS: This study enrolled 200 preterm infants with a gestational age of 26-32 weeks who showed signs of respiratory distress but did not require intubation in the delivery room...
July 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26135952/lisa-surfactant-administration-in-spontaneous-breathing-which-evidence-from-the-literature
#6
G Lista, A La Verde, F Castoldi
Recent human and animal studies demonstrated that surfactant can be delivered intratracheally without traditional intubation and bagging, but using a fine catheter inserted into the trachea of spontaneously breathing preterm infants on CPAP. This strategy, known as LISA (less invasive surfactant administration) or MIST (minimal invasive surfactant therapy), seems to reduce failure of non-invasive respiratory approach. Avoiding mechanical ventilation and manual inflation it is possible to reduce lung injury due to baro-volutrauma...
June 29, 2015: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/26028565/-surfactant-replacement-therapy-with-a-minimally-invasive-technique-experience-in-a-tertiary-hospital
#7
F J Canals Candela, C Vizcaíno Díaz, M J Ferrández Berenguer, M I Serrano Robles, C Vázquez Gomis, J L Quiles Durá
INTRODUCTION: Surfactant delivered using a minimally invasive technique, known as MIST (Minimally Invasive Surfactant Therapy) is a method which allows surfactant to be administered to a patient connected to non-invasive respiratory support. This is an increasingly used therapy in Neonatal Units that reduces the intubation rate and the pathology associated with intubation and allows the surfactant to be administered to the patients who clinically need it. PATIENTS AND METHODS: In years 2013 and 2014 in the Hospital General Universitario de Elche surfactant was delivered using this method to 19 patients, five of whom were 28 or less weeks of gestation age at birth...
February 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/25164872/the-optimist-a-trial-evaluation-of-minimally-invasive-surfactant-therapy-in-preterm-infants-25-28-weeks-gestation
#8
RANDOMIZED CONTROLLED TRIAL
Peter A Dargaville, Camille Omar F Kamlin, Antonio G De Paoli, John B Carlin, Francesca Orsini, Roger F Soll, Peter G Davis
BACKGROUND: It is now recognized that preterm infants ≤28 weeks gestation can be effectively supported from the outset with nasal continuous positive airway pressure. However, this form of respiratory therapy may fail to adequately support those infants with significant surfactant deficiency, with the result that intubation and delayed surfactant therapy are then required. Infants following this path are known to have a higher risk of adverse outcomes, including death, bronchopulmonary dysplasia and other morbidities...
2014: BMC Pediatrics
https://www.readbyqxmd.com/read/25089718/minimally-invasive-surfactant-administration-in-preterm-infants-a-meta-narrative-review
#9
REVIEW
Kiran More, Pankaj Sakhuja, Prakesh S Shah
IMPORTANCE: Surfactant administration by minimally invasive methods that allow for spontaneous breathing might be safer and more effective than administration with endotracheal intubation and mechanical ventilation; however, the efficacy and safety of minimally invasive methods have not been reviewed. OBJECTIVE: To conduct a meta-narrative review of the efficacy and safety of minimally invasive surfactant administration using a thin catheter, aerosolization, a laryngeal mask airway, and pharyngeal administration in preterm infants with or at risk for respiratory distress syndrome...
October 2014: JAMA Pediatrics
https://www.readbyqxmd.com/read/24628379/minimally-invasive-surfactant-therapy-with-a-gastric-tube-is-as-effective-as-the-intubation-surfactant-and-extubation-technique-in-preterm-babies
#10
COMPARATIVE STUDY
Marta Aguar, María Cernada, María Brugada, Ana Gimeno, Antonio Gutierrez, Máximo Vento
AIM: Preterm infants requiring surfactant replacement have been treated using the INSURE technique, which requires sedation and comprises tracheal intubation, surfactant instillation and extubation. However, minimally invasive surfactant therapy (MIST) does not require sedation, minimises airway injury and avoids placing positive pressure ventilation on an immature lung. This study compared the feasibility of the two techniques and the outcomes in preterm babies with respiratory distress syndrome (RDS)...
June 2014: Acta Paediatrica
https://www.readbyqxmd.com/read/24112693/exogenous-surfactant-therapy-in-2013-what-is-next-who-when-and-how-should-we-treat-newborn-infants-in-the-future
#11
REVIEW
Emmanuel Lopez, Géraldine Gascoin, Cyril Flamant, Mona Merhi, Pierre Tourneux, Olivier Baud
BACKGROUND: Surfactant therapy is one of the few treatments that have dramatically changed clinical practice in neonatology. In addition to respiratory distress syndrome (RDS), surfactant deficiency is observed in many other clinical situations in term and preterm infants, raising several questions regarding the use of surfactant therapy. OBJECTIVES: This review focuses on several points of interest, including some controversial or confusing topics being faced by clinicians together with emerging or innovative concepts and techniques, according to the state of the art and the published literature as of 2013...
2013: BMC Pediatrics
https://www.readbyqxmd.com/read/24027691/preliminary-evaluation-of-a-new-technique-of-minimally-invasive-surfactant-therapy
#12
Yahya Al Ethawi
No abstract text is available yet for this article.
April 2012: Journal of Clinical Neonatology
https://www.readbyqxmd.com/read/23791070/-mechanical-ventilation-in-acute-respiratory-distress-syndrome
#13
REVIEW
Ya-Mei Wang, Yu-Hong Tao
The goal of mechanically ventilating patients with acute respiratory distress syndrome (ARDS) is to ensure adequate oxygenation and minimal ventilator-associated lung injury. Non-invasive ventilation should be cautiously used in patients with ARDS. Protective ARDS mechanical ventilation strategies with low tidal volumes can reduce mortality. Driving pressure is the most reasonable parameter to optimize tidal volume. Available evidence does not support the routine use of higher positive end expiratory pressure (PEEP) in patients with ARDS...
June 2013: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/23523160/pulmonary-alveolar-proteinosis-requiring-hybrid-extracorporeal-life-support-and-complicated-by-acute-necrotizing-pneumonia
#14
M Moisan, M Lafargue, J Calderon, P Oses, A Ouattara
Pulmonary alveolar proteinosis (PAP), which was first described by Rosen in 1958, is a rare disease characterized by impaired surfactant metabolism that provokes the accumulation of proteinaceous material in the alveoli. PAP is usually an auto-immune disease though, less commonly, may be congenital or secondary to another underlying disorder, such as infection, an immunodeficiency or a haematological disease. A positive diagnosis can be made with the appearance of "crazy-paving" on a computed tomography scan, with a milky fluid bronchial aspiration...
April 2013: Annales Françaises D'anesthèsie et de Rèanimation
https://www.readbyqxmd.com/read/22940622/innovation-in-surfactant-therapy-i-surfactant-lavage-and-surfactant-administration-by-fluid-bolus-using-minimally-invasive-techniques
#15
REVIEW
Peter A Dargaville
Innovation in the field of exogenous surfactant therapy continues more than two decades after the drug became commercially available. One such innovation, lung lavage using dilute surfactant, has been investigated in both laboratory and clinical settings as a treatment for meconium aspiration syndrome (MAS). Studies in animal models of MAS have affirmed that dilute surfactant lavage can remove meconium from the lung, with resultant improvement in lung function. In human infants both non-randomised studies and two randomised controlled trials have demonstrated a potential benefit of dilute surfactant lavage over standard care...
2012: Neonatology
https://www.readbyqxmd.com/read/22814222/aerosolized-liposomal-amphotericin-b-prediction-of-lung-deposition-in-vitro-uptake-and-cytotoxicity
#16
Mélanie Fauvel, Cécile Farrugia, Nicolas Tsapis, Claire Gueutin, Odile Cabaret, Christian Bories, Stéphane Bretagne, Gillian Barratt
To predict the efficacy and toxicity of pulmonary administration of liposomal amphotericin B (L-AMB) for the treatment or the prevention of pulmonary invasive aspergillosis, a multistage liquid impinger was used to estimate the concentrations of drug that could be attained in different lung compartments after nebulization. The highest concentration of amphotericin B was found in the alveolar compartment, where it was calculated that the concentration in the lung surfactant could reach 54 μM or more when 21...
October 15, 2012: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/22684154/minimally-invasive-surfactant-therapy-in-preterm-infants-on-continuous-positive-airway-pressure
#17
MULTICENTER STUDY
Peter A Dargaville, Ajit Aiyappan, Antonio G De Paoli, Carl A Kuschel, C Omar F Kamlin, John B Carlin, Peter G Davis
OBJECTIVE: To evaluate the applicability and potential effectiveness of a technique of minimally-invasive surfactant therapy (MIST) in preterm infants on continuous positive airway pressure (CPAP). METHODS: An open feasibility study of MIST was conducted at two sites. Infants were eligible for MIST if needing CPAP pressure ≥7 cm H(2)O and FiO(2) ≥0.3 (25-28 weeks gestation, n=38) or ≥0.35 (29-32 weeks, n=23). Without premedication, a narrow-bore catheter was inserted through the vocal cords under direct vision...
March 2013: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/21090074/-the-well-being-of-the-newborn-infant-in-neonatal-intensive-care
#18
REVIEW
G Ancora
Patients referred to Neonatal Intensive Care Units are particularly vulnerable because they are in a critical or sensitive period of development. When physicians were first able to really save preemies 40 years ago, not much thought was given to their brain development. The babies we care for are so early that the brain cells are still migrating to where they will finally rest in developed brain. We are shaped, to an extent, by our environment. In early life, the environment takes on a particularly important role...
June 2010: Minerva Pediatrica
https://www.readbyqxmd.com/read/20971722/preliminary-evaluation-of-a-new-technique-of-minimally-invasive-surfactant-therapy
#19
Peter A Dargaville, Ajit Aiyappan, Anita Cornelius, Christopher Williams, Antonio G De Paoli
OBJECTIVE: To investigate a method of minimally invasive surfactant therapy (MIST) to be used in spontaneously breathing preterm infants on continuous positive airway pressure (CPAP), evaluating the feasibility of the technique and the therapeutic benefit after MIST. DESIGN: Non-randomised feasibility study. SETTING: Tertiary neonatal intensive care unit. PATIENTS AND INTERVENTIONS: Study subjects were preterm infants with respiratory distress supported with CPAP, with early enrolment of 25-28-week infants (n=11) at any CPAP pressure and fractional inspired O(2) concentration (FiO(2)), and enrolment of 29-34-week infants (n=14) at CPAP pressure ≥7 cm H(2)O and FiO(2) ≥0...
July 2011: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/20877411/nasal-respiratory-support-through-the-nares-its-time-has-come
#20
REVIEW
R Ramanathan
Respiratory distress syndrome (RDS) is the most common respiratory morbidity in preterm infants. Surfactant therapy and invasive mechanical ventilation through the endotracheal tube (ETT) have been the cornerstones in RDS management. Despite improvements in the provision of mechanical ventilation, bronchopulmonary dysplasia (BPD), a multifactorial disease in which invasive mechanical ventilation is a known contributory factor, remains an important cause of morbidity among preterm infants. Barotrauma, volutrauma or oxygen-induced lung inflammation (oxy-trauma) contributes significantly to the development of BPD in neonates ventilated through an ETT...
October 2010: Journal of Perinatology: Official Journal of the California Perinatal Association
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