Ryan A Blaustein, Zeyang Shen, Sara Saheb Kashaf, ShihQueen Lee-Lin, Sean Conlan, Marita Bosticardo, Ottavia M Delmonte, Cassandra J Holmes, Monica E Taylor, Glenna Banania, Keisuke Nagao, Dimana Dimitrova, Jennifer A Kanakry, Helen Su, Steven M Holland, Jenna R E Bergerson, Alexandra F Freeman, Luigi D Notarangelo, Heidi H Kong, Julia A Segre
The complex interplay between microbiota and immunity is important to human health. To explore how altered adaptive immunity influences the microbiome, we characterize skin, nares, and gut microbiota of patients with recombination-activating gene (RAG) deficiency-a rare genetically defined inborn error of immunity (IEI) that results in a broad spectrum of clinical phenotypes. Integrating de novo assembly of metagenomes from RAG-deficient patients with reference genome catalogs provides an expansive multi-kingdom view of microbial diversity...
September 20, 2023: Cell reports medicine