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healthy skin program

M Mauro, V De Giusti, M Bovenzi, F LareseFilon
BACKGROUND: Occupational skin diseases are often responsible for sick leave or job changes, affect mostly young subjects, are costly to society and have been reported as significant predictor of unemployment. OBJECTIVES: To assess over time the course of occupational hand dermatitis (OHD), after a specific training, by means of follow up visits and TEWL measurement, to evaluate skin barrier integrity and if preventive measures for hand skin care provided may influence the course of the disease...
August 25, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Jay-Hyun Jo, Clayton Deming, Elizabeth A Kennedy, Sean Conlan, Eric C Polley, Weng-Lan Ng, Julia A Segre, Heidi H Kong
Understanding the skin mycobiome (fungal communities) is important because both commensal and pathogenic fungi can drive cutaneous disease depending on host status and body sites, including the scalp, feet, and groin. Interestingly, age may also affect skin fungal infections as certain dermatophytoses (i.e. tinea capitis) are more frequent in children than adults. We previously described the skin mycobiomes in healthy adults, showing lipophilic fungi Malassezia predominate in most skin sites. Since children have less sebaceous skin before puberty, we compared the fungal communities of primary clinical samples from healthy children and adults, based on sequencing of a fungal phylogenetic marker...
July 28, 2016: Journal of Investigative Dermatology
Bhavana Prasher, Binuja Varma, Arvind Kumar, Bharat Krushna Khuntia, Rajesh Pandey, Ankita Narang, Pradeep Tiwari, Rintu Kutum, Debleena Guin, Ritushree Kukreti, Debasis Dash, Mitali Mukerji
BACKGROUND: Genetic differences in the target proteins, metabolizing enzymes and transporters that contribute to inter-individual differences in drug response are not integrated in contemporary drug development programs. Ayurveda, that has propelled many drug discovery programs albeit for the search of new chemical entities incorporates inter-individual variability "Prakriti" in development and administration of drug in an individualized manner. Prakriti of an individual largely determines responsiveness to external environment including drugs as well as susceptibility to diseases...
July 22, 2016: Journal of Ethnopharmacology
R Scharfenort, M Menz, T B Lonsdorf
The efficacy of current treatments for anxiety disorders is limited by high relapse rates. Relapse of anxiety disorders and addiction can be triggered by exposure to life adversity, but the underlying mechanisms remain unexplored. Seventy-six healthy adults were a priori selected for the presence or absence of adverse experiences during childhood (CA) and recent past (RA; that is, past 12 months). Participants underwent fear conditioning (day 1) and fear extinction and experimental return-of-fear (ROF) induction through reinstatement (a model for adversity-induced relapse; day 2)...
2016: Translational Psychiatry
Livio Provenzi, Lorenzo Giusti, Monica Fumagalli, Hilarj Tasca, Francesca Ciceri, Giorgia Menozzi, Fabio Mosca, Francesco Morandi, Renato Borgatti, Rosario Montirosso
Very preterm (VPT) infants are hospitalized in the Neonatal Intensive Care Unit (NICU) and exposed to varying levels of skin-breaking procedures (pain-related stress), even in absence of severe clinical conditions. Repeated and prolonged pain exposure may alter hypothalamic-pituitary-adrenal (HPA) axis reactivity in VPT infants. During the post-discharge period, altered HPA axis reactivity has been documented in response to non-social stressors, using salivary cortisol as a biomarker. However, little is known about the effects of NICU pain-related stress on subsequent HPA axis reactivity to socio-emotional stress in infants...
October 2016: Psychoneuroendocrinology
Alison Volpe Holmes, Emily C Atwood, Bonny Whalen, Johanna Beliveau, J Dean Jarvis, John C Matulis, Shawn L Ralston
BACKGROUND AND OBJECTIVE: The incidence and associated costs of neonatal abstinence syndrome (NAS) have recently risen sharply; newborns with NAS occupy 4% of NICU beds. We implemented a coordinated program for NAS including standardized protocols for scoring, medications and weaning, and a calm rooming-in environment, to improve family-centered care and to decrease both length of stay (LOS) and hospital costs. METHODS: In early 2013, a multidisciplinary quality improvement team began consecutive plan-do-study-act (PDSA) cycles...
June 2016: Pediatrics
Midori Motoi, Takayuki Nishimura, Yuka Egashira, Fumi Kishida, Shigeki Watanuki
We aimed to investigate the relationship between mtDNA polymorphism and physiological responses to hypobaric hypoxia. The study included 28 healthy male students, consisting of 18 students in haplogroup D and 10 in haplogroup M7+G. Measurement sensors were attached to the participants for approximately 30 min in an environment with a temperature of 28 °C. After resting for 15 min, the programmed operation of the hypobaric chamber decreased the atmospheric pressure by 11.9 Torr every minute to simulate an increase in altitude of 150 m until 9...
2016: Journal of Physiological Anthropology
Elisa M Bolatti, Diego Chouhy, Pablo E Casal, Germán R Pérez, Emma J Stella, Adriana Sanchez, Mario Gorosito, Ramón Fernandez Bussy, Adriana A Giri
Gammapapillomavirus (γ-PV) is a diverse and rapidly expanding genus, currently consisting of 79 fully characterized human PV (HPV) types. In this study, three novel types, HPV157, HPV158 and HPV205, obtained from healthy sun-exposed skin of two immunocompetent individuals, were amplified by the "Hanging droplet" long PCR technique, cloned, sequenced and characterized. HPV157, HPV158 and HPV205 genomes comprise 7154-bp, 7192-bp and 7298-bp, respectively, and contain four early (E1, E2, E6 and E7) and two late genes (L1 and L2)...
August 2016: Infection, Genetics and Evolution
Lu Hao, Jipeng Xie, Shanyi Chen, Shaojie Wang, Zhuoqun Gong, Kai-Shu Ling, Liyun Guo, Zaifeng Fan, Tao Zhou
Apple chlorotic leaf spot virus (ACLSV), Apple stem grooving virus (ASGV), and Apple stem pitting virus (ASPV) are three latent viruses frequently occurring in apple trees worldwide. In field orchards, these viruses are frequently found in a mixed infection with viroids in the genus Apscarviroid, including Apple scar skin viroid, and Apple dimple fruit viroid. Together these viruses and viroids could cause serious damage to apple fruit production worldwide. Rapid and efficient detection methods are pivotal to identify and select the virus-free propagation material for healthy apple orchard management...
August 2016: Journal of Virological Methods
Jessica A Grieger, Vicki L Clifton, Astrud R Tuck, Amy L Wooldridge, Sarah A Robertson, Kathryn L Gatford
BACKGROUND: Around 30-40% of the world's population will experience allergy, the most common and earliest-onset noncommunicable disease. With a steady rise in the incidence of allergic disease over recent decades, up to 18% of children will suffer a respiratory, food or skin allergy before their 18th birthday. There is compelling evidence that the risk of developing allergy is influenced by early life events and particularly in utero exposures. METHODS: A comprehensive literature review was undertaken which outlines prenatal risk factors and potential mechanisms underlying the development of allergy in childhood...
2016: International Archives of Allergy and Immunology
E Robert Burns
Skin cancer, especially malignant melanoma, continues on the increase. Different interventions are attempting to impact on this problem. The approach used by the Partners in Health Sciences program at the University of Arkansas for Medical Science is to both "train" and, importantly, "equip" classroom teachers and school nurses in a "Healthy Skin" professional development curriculum. Each participant not only received face-to-face interactive content training in a workshop setting that lasted 6 h; each also received a resource kit of supplies, materials, and equipment used in the workshop and designed for the trainee to use with students in a classroom/school setting...
March 22, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
Katherine E Corder, Katherine R Newsham, Jennifer L McDaniel, Uthayashanker R Ezekiel, Edward P Weiss
The omega-3 fatty acid docosahexaenoic acid (DHA) has anti-inflammatory and anti-nociceptive (pain inhibiting) effects. Because strenuous exercise often results in local inflammation and pain, we hypothesized that DHA supplementation attenuates the rise in markers of local muscle inflammation and delayed onset muscle soreness (DOMS) that occur after eccentric strength exercise. Twenty-seven, healthy women (33 ± 2 y, BMI 23.1±1.0 kg·m(-2)) were randomized to receive 9d of 3000 mg/d DHA or placebo in a double-blind fashion...
March 2016: Journal of Sports Science & Medicine
Koichi Yanaba, Mitsuha Hayashi, Yuki Yoshihara, Hidemi Nakagawa
The interaction of programmed death-1 (PD-1) with its ligand, programmed death ligand-1 (PD-L1), has been considered to play a key role in the negative regulation of immune responses. Patients with diffuse cutaneous systemic sclerosis (SSc) had higher levels of soluble PD-1 (sPD-1) than those with limited cutaneous SSc and healthy individuals. Serum sPD-1 levels positively correlated with the severity of skin sclerosis. In contrast, serum sPD-L1 levels were significantly increased in patients with SSc compared with healthy individuals...
August 2016: Journal of Dermatology
Ulrike Blume-Peytavi, Tina Lavender, Dorota Jenerowicz, Irina Ryumina, Jean-Francois Stalder, Antonio Torrelo, Michael J Cork
BACKGROUND: European roundtable meeting recommendations on bathing and cleansing of infants were published in 2009; a second meeting was held to update and expand these recommendations in light of new evidence and the continued need to address uncertainty surrounding this aspect of routine care. METHODS: The previous roundtable recommendations concerning infant cleansing, bathing, and use of liquid cleansers were critically reviewed and updated and the quality of evidence was evaluated using the Grading of Recommendation Assessment, Development and Evaluation system...
May 2016: Pediatric Dermatology
Jong Ho Kang
[Purpose] The purpose of the present study was to compare the sensory thresholds of healthy subjects using pre-programmed or single-frequency transcutaneous electrical nerve stimulation. [Subjects] Ninety healthy adult subjects were randomly assigned to pre-programmed or single-frequency stimulation groups, each consisting of 45 participants. [Methods] Sensory thresholds were measured in the participants' forearms using von Frey filaments before and after pre-programmed or single-frequency transcutaneous electrical nerve stimulation, and the result in values were analyzed...
December 2015: Journal of Physical Therapy Science
Ho-Keun Kwon, Gi-Cheon Kim, Ji Sun Hwang, Young Kim, Chang-Suk Chae, Jong Hee Nam, Chang-Duk Jun, Dipayan Rudra, Charles D Surh, Sin-Hyeog Im
Allergic contact hypersensitivity (CHS) is an inflammatory skin disease mediated by allergen specific T cells. In this study, we investigated the role of transcription factor NFAT1 in the pathogenesis of contact hypersensitivity. NFAT1 knock out (KO) mice spontaneously developed CHS-like skin inflammation in old age. Healthy young NFAT1 KO mice displayed enhanced susceptibility to hapten-induced CHS. Both CD4(+) and CD8(+) T cells from NFAT1 KO mice displayed hyper-activated properties and produced significantly enhanced levels of inflammatory T helper 1(Th1)/Th17 type cytokines...
2016: Scientific Reports
Vanessa C Denny, James S Cassese, Kathryn H Jacobsen
INTRODUCTION: The burden of injuries in Pacific Island countries is understudied despite the known challenges associated with many residents having limited access to advanced medical and surgical care when they sustain a serious injury. This paper examines nonfatal injuries among early adolescent schoolchildren (those primarily ages 13-15 years) from four Polynesian countries. METHODS: Self-reported data from the 5507 middle school students who were randomly sampled for participation in the nationwide Global School-based Student Health Surveys (GSHS) in the Cook Islands (in the year 2009), Niue (2010), Samoa (2011), and Tonga (2010) were analysed with various statistical methods including regression models...
May 2016: Injury
E Makrantonaki, G P Pfeifer, C C Zouboulis
Skin aging is determined by a combination of endogenous and environmental influences, including epigenetic, posttranslational, microbial, and lifestyle factors. In particular genetic changes, programmed or not, play a pivotal role and understanding of these complex mechanisms may contribute to the prevention of age-related diseases and extension of healthy lifespan. In this article, new knowledge about genes and biological processes that can significantly affect skin homeostasis in old age and can lead to the typical morphological and physiological characteristics of aging skin are summarized...
February 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Jue Xie, Yan Liu, Lei Wang, Guoxiang Ruan, Huiming Yuan, Hong Fang, Jianyong Wu, Dawei Cui
Henoch-Schönlein purpura (HSP) is a common systemic small vessel vasculitis in children with disorder autoimmune responses. T follicular helper (TFH) cells play crucial roles in regulating immune responses. The aim of our study was to investigate the probable role of TFH cells in the pathogenesis of children with HSP. In this study, the frequency of circulating CXCR5(+)CD4(+)TFH cells with inducible costimulator (ICOS) expression in the children with acute HSP was significantly higher than that in healthy controls (HCs) but not CXCR5(+)CD4(+)TFH cells with programmed death-1 (PD-1) expression...
2015: Journal of Immunology Research
Ari Leshno, Shiran Shapira, Eliezer Liberman, Sarah Kraus, Miri Sror, Amira Harlap-Gat, Doran Avivi, Lior Galazan, Maayan David, Nitsan Maharshak, Serhan Moanis, Nadir Arber, Menachem Moshkowitz
This study is the first attempt to evaluate the association between the APC I1307K variant and overall cancer risk. It is unique in both its large sample size and in the reliability of data in the control group. The findings described in this article have major implications in terms of identifying asymptomatic individuals who are at increased risk to harbor cancer and therefore targeted to be enrolled in specific early detection and prevention programs. The prevalence of the APC I1307K missense mutation among Ashkenazi Jews is ∼ 6%...
March 15, 2016: International Journal of Cancer. Journal International du Cancer
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