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https://www.readbyqxmd.com/read/29075175/three-dimensional-trunk-and-lower-limbs-characteristics-during-gait-in-patients-with-huntington-s-disease
#1
Elzbieta Mirek, Magdalena Filip, Wiesław Chwała, Krzysztof Banaszkiewicz, Monika Rudzinska-Bar, Jadwiga Szymura, Szymon Pasiut, Andrzej Szczudlik
Objective: A number of studies on gait disturbances have been conducted, however, no clear pattern of gait disorders was described. The aim of the study was to characterize the gait pattern in HD patients by conducting analysis of mean angular movement changes the lower limb joints and trunk (kinematics parameters). Methods: The study group consisted of 30 patients with HD (17 women and 13 men). The reference data include the results of 30 healthy subjects (17 women and 13 men). Registration of gait with the Vicon 250 system was performed using passive markers attached to specific anthropometric points directly on the skin, based on the Golem biomechanical model (Oxford Metrics Ltd...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29063138/decision-making-somatic-markers-and-emotion-processing-in-opiate-users
#2
Kathryn Biernacki, Gill Terrett, Skye N McLennan, Izelle Labuschagne, Phoebe Morton, Peter G Rendell
RATIONALE: Opiate use is associated with deficits in decision-making. A possible explanation for these deficits is provided by the somatic marker hypothesis, which suggests that substance users may experience abnormal emotional responses during decision-making involving reward and punishment. This in turn may interfere with the brief physiological arousal, i.e. somatic markers that normally occur in anticipation of risky decisions. To date, the applicability of the somatic marker hypothesis to explain decision-making deficits has not been investigated in opiate users...
October 23, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28991156/baseline-assessment-of-a-healthy-corner-store-initiative-associations-between-food-store-environments-shopping-patterns-customer-purchases-and-dietary-intake-in-eastern-north-carolina
#3
Stephanie B Jilcott Pitts, Qiang Wu, Kimberly P Truesdale, Melissa N Laska, Taras Grinchak, Jared T McGuirt, Lindsey Haynes-Maslow, Ronny A Bell, Alice S Ammerman
In 2016, the North Carolina (NC) Legislature allocated $250,000 to the NC Department of Agriculture, to identify and equip small food retailers to stock healthier foods and beverages in eastern NC food deserts (the NC Healthy Food Small Retailer Program, HFSRP). The purpose of this study was to examine associations between food store environments, shopping patterns, customer purchases, and dietary consumption among corner store customers. We surveyed 479 customers in 16 corner stores regarding demographics, food purchased, shopping patterns, and self-reported fruit, vegetable, and soda consumption...
October 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28827448/egf-hijacks-mir-198-fstl1-wound-healing-switch-and-steers-a-two-pronged-pathway-toward-metastasis
#4
Gopinath M Sundaram, Hisyam M Ismail, Mohsin Bashir, Manish Muhuri, Candida Vaz, Srikanth Nama, Ghim Siong Ow, Ivshina Anna Vladimirovna, Rajkumar Ramalingam, Brian Burke, Vivek Tanavde, Vladimir Kuznetsov, E Birgitte Lane, Prabha Sampath
Epithelial carcinomas are well known to activate a prolonged wound-healing program that promotes malignant transformation. Wound closure requires the activation of keratinocyte migration via a dual-state molecular switch. This switch involves production of either the anti-migratory microRNA miR-198 or the pro-migratory follistatin-like 1 (FSTL1) protein from a single transcript; miR-198 expression in healthy skin is down-regulated in favor of FSTL1 upon wounding, which enhances keratinocyte migration and promotes re-epithelialization...
October 2, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28755424/healthy-skin-wins-a-glowing-pressure-ulcer-prevention-program-that-can-guide-evidence-based-practice
#5
Donna Martin, Lisa Albensi, Stephanie Van Haute, Maria Froese, Mary Montgomery, Mavis Lam, Kendra Gierys, Rob Lajeunesse, Lorna Guse, Nataliya Basova
BACKGROUND: In 2013, an observational survey was conducted among 242 in-patients in a community hospital with a pressure ulcer (PU) prevalence of 34.3%. An evidence-based pressure ulcer prevention program (PUPP) was then implemented including a staff awareness campaign entitled "Healthy Skin Wins" with an online tutorial about PU prevention. AIMS: To determine the effectiveness of the PUPP in reducing the prevalence of PUs, to determine the effectiveness of the online tutorial in increasing hospital staff's knowledge level about PU prevention, and to explore frontline staff's perspectives of the PUPP...
July 29, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28747837/evaluation-of-pulmonary-functions-in-preschool-children-born-late-preterm
#6
İlkay Er, Ayla Günlemez, Zeynep Seda Uyan, Metin Aydoğan, Meral Oruç, Olcay Işık, Ayşe Engin Arısoy, Canan Baydemir, Ayşe Sevim Gökalp
AIM: The aim of this study was to evaluate the pulmonary functions of preschool children born late-preterm. MATERIAL AND METHODS: Children aged between 3-7 years who were born at 34(0/7-)36(6/7) weeks' gestation represented the target sample. Patients with a diagnosis of congenital cardiac, pulmonary and/or muscle diseases were excluded. Respiratory symptoms were evaluated using the modified asthma predictive index and International Study of Asthma and Allergies in Childhood criteria for children aged under and over 6 years, respectively...
June 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28705150/economic-burden-of-varicella-in-children-1-12%C3%A2-years-of-age-in-hungary-2011-2015
#7
MULTICENTER STUDY
Z Meszner, Z Molnar, E Rampakakis, H K Yang, B J Kuter, Lara J Wolfson
BACKGROUND: Although live-attenuated varicella-zoster virus (VZV) vaccines have been proven to be safe and effective in preventing varicella and real-word evidence shows routine childhood immunization programs are effective in dramatically reducing varicella associated morbidity and mortality, varicella vaccine is not included in the National Immunization Program (NIP) in Hungary. The purpose of this study was to evaluate the clinical and economic burden associated with varicella in Hungary...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28341018/using-skin-carotenoids-to-assess-dietary-changes-in-students-after-1-academic-year-of-participating-in-the-shaping-healthy-choices-program
#8
Lori M Beccarelli, Rachel E Scherr, Madan Dharmar, Igor V Ermakov, Werner Gellermann, Lisa Jahns, Jessica D Linnell, Carl L Keen, Francene M Steinberg, Heather M Young, Sheri Zidenberg-Cherr
OBJECTIVE: To determine whether fourth-grade students participating in the Shaping Healthy Choices Program (SHCP), a school-based nutrition intervention, would change vegetable and carotenoid intake measured by skin carotenoids and dietary intake. METHODS: Single-group pretest-posttest with a self-selected, convenience sample of students (n = 30) participating in the SHCP, which lasted 1 academic year (9 months). Dietary intake of vegetables and carotenoids as measured by Block food frequency questionnaire and skin carotenoids as measured by Raman spectroscopy were collected at the school preintervention and postintervention...
January 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28245835/the-effectiveness-of-a-skin-care-program-for-the-prevention-of-contact-dermatitis-in-health-care-workers-the-healthy-hands-project-study-protocol-for-a-cluster-randomized-controlled-trial
#9
Maryam Soltanipoor, Sanja Kezic, Judith K Sluiter, Thomas Rustemeyer
BACKGROUND: Health care workers (HCW) are at high risk for developing occupational hand dermatitis (HD) due to frequent exposure to 'wet work'. Amongst HCWs, nurses are at highest risk, with an estimated point prevalence of HD ranging between 12 and 30%. The burden of disease is high with chronicity, sick leave, risk of unemployment and impaired quality of life. Despite evidence from the medical literature on the risk factors and the importance of skin care in the prevention of HD, in practice, compliance to skin care protocols are below 30%...
February 28, 2017: Trials
https://www.readbyqxmd.com/read/28099044/effect-of-early-skin-to-skin-mother-infant-contact-in-the-maintenance-of-exclusive-breastfeeding
#10
Rafael Vila-Candel, Kiri Duke, F Javier Soriano-Vidal, Enrique Castro-Sánchez
BACKGROUND: Breastfeeding has been shown to result in extensive physical and psychological benefits for both the mother and the newborn. However, the rate and duration of exclusive breastfeeding (EBF) remains low worldwide. Mother-infant skin-to-skin contact (SSC) immediately after birth has demonstrated results that support the argument for breastfeeding continuation. Research aim: This study aimed to investigate the prevalence of EBF 3 months postpartum and the effect of early SSC in maintaining optimal EBF practices for mothers and their healthy newborns...
January 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/27935889/-current-aspects-of-endothelial-protection-in-treatment-of-patients-with-chronic-venous-insufficiency-at-the-stage-of-trophic-disorders
#11
Yu M Stoiko, V G Gudymovich, A V Tsyplyashchuk
The authors analysed the results of comprehensive examination and treatment of a total of 40 patients presenting with lower limb chronic venous insufficiency at the stage of trophic disorders (class C6), including 28 (70%) patients with varicose disease of lower extremities and 12 (30%) patients with post-thrombotic disease. Studying the microcirculatory blood flow by means of laser Doppler flowmetry showed a statistically significant (p<0.05) baseline decrease in the index of microcirculation in patients (12...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27903442/are-micrornas-true-sensors-of-ageing-and-cellular-senescence
#12
REVIEW
Justin Williams, Flint Smith, Subodh Kumar, Murali Vijayan, P Hemachandra Reddy
All living beings are programmed to death due to aging and age-related processes. Aging is a normal process of every living species. While all cells are inevitably progressing towards death, many disease processes accelerate the aging process, leading to senescence. Pathologies such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington's disease, cardiovascular disease, cancer, and skin diseases have been associated with deregulated aging. Healthy aging can delay onset of all age-related diseases...
May 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/27885658/early-skin-to-skin-contact-for-mothers-and-their-healthy-newborn-infants
#13
REVIEW
Elizabeth R Moore, Nils Bergman, Gene C Anderson, Nancy Medley
BACKGROUND: Mother-infant separation post birth is common. In standard hospital care, newborn infants are held wrapped or dressed in their mother's arms, placed in open cribs or under radiant warmers. Skin-to-skin contact (SSC) begins ideally at birth and should last continually until the end of the first breastfeeding. SSC involves placing the dried, naked baby prone on the mother's bare chest, often covered with a warm blanket. According to mammalian neuroscience, the intimate contact inherent in this place (habitat) evokes neuro-behaviors ensuring fulfillment of basic biological needs...
November 25, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27782829/the-effect-of-skin-to-skin-contact-at-birth-early-versus-immediate-on-the-duration-of-exclusive-human-lactancy-in-full-term-newborns-treated-at-the-cl%C3%A3-nica-universidad-de-la-sabana-study-protocol-for-a-randomized-clinical-trial
#14
Sergio Agudelo, Oscar Gamboa, Fabio Rodríguez, Sandra Cala, Nathalie Gualdrón, Evelyn Obando, María Lucía Padrón
BACKGROUND: Human lactancy is a simple and cost-effective strategy that influences infant and maternal mortality rates. Skin-to-skin contact (SSC) is an immediate postpartum period strategy that has proven to benefit the initiation and continuation of human lactation and to decrease hospitalization during the first week of life. This study aims to determine the effect of SSC initiation at birth (immediate versus early) in healthy, full-term newborns treated at the Universidad de La Sabana Clinic on the duration of exclusive human lactation...
October 26, 2016: Trials
https://www.readbyqxmd.com/read/27558199/effectiveness-of-a-secondary-prevention-protocol-for-occupational-contact-dermatitis
#15
M Mauro, V De Giusti, M Bovenzi, F Larese Filon
BACKGROUND: Occupational skin diseases are often responsible for sick leave or job changes, affect mostly young subjects, are costly to society and have been reported as significant predictor of unemployment. OBJECTIVES: To assess, over time, the course of occupational hand dermatitis (OHD) after a specific training, by means of follow-up visits and TEWL measurement, to evaluate skin barrier integrity and if preventive measures for hand skin care provided may influence the course of the disease...
April 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27476723/diverse-human-skin-fungal-communities-in-children-converge-in-adulthood
#16
COMPARATIVE STUDY
Jay-Hyun Jo, Clay Deming, Elizabeth A Kennedy, Sean Conlan, Eric C Polley, Weng-Lan Ng, Julia A Segre, Heidi H Kong
Understanding the skin mycobiome (fungal communities) is important because both commensal and pathogenic fungi can drive cutaneous disease depending on host status and body sites, including the scalp, feet, and groin. Interestingly, age may also affect skin fungal infections as certain dermatophytoses (i.e., tinea capitis) are more frequent in children than adults. We previously described the skin mycobiomes in healthy adults, showing lipophilic fungi Malassezia predominate in most skin sites. Because children have less sebaceous skin before puberty, we compared the fungal communities of primary clinical samples from healthy children and adults, based on sequencing of a fungal phylogenetic marker...
December 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27457695/ayurgenomics-for-stratified-medicine-trisutra-consortium-initiative-across-ethnically-and-geographically-diverse-indian-populations
#17
REVIEW
Bhavana Prasher, Binuja Varma, Arvind Kumar, Bharat Krushna Khuntia, Rajesh Pandey, Ankita Narang, Pradeep Tiwari, Rintu Kutum, Debleena Guin, Ritushree Kukreti, Debasis Dash, Mitali Mukerji
BACKGROUND: Genetic differences in the target proteins, metabolizing enzymes and transporters that contribute to inter-individual differences in drug response are not integrated in contemporary drug development programs. Ayurveda, that has propelled many drug discovery programs albeit for the search of new chemical entities incorporates inter-individual variability "Prakriti" in development and administration of drug in an individualized manner. Prakriti of an individual largely determines responsiveness to external environment including drugs as well as susceptibility to diseases...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27434492/adversity-induced-relapse-of-fear-neural-mechanisms-and-implications-for-relapse-prevention-from-a-study-on-experimentally-induced-return-of-fear-following-fear-conditioning-and-extinction
#18
R Scharfenort, M Menz, T B Lonsdorf
The efficacy of current treatments for anxiety disorders is limited by high relapse rates. Relapse of anxiety disorders and addiction can be triggered by exposure to life adversity, but the underlying mechanisms remain unexplored. Seventy-six healthy adults were a priori selected for the presence or absence of adverse experiences during childhood (CA) and recent past (RA; that is, past 12 months). Participants underwent fear conditioning (day 1) and fear extinction and experimental return-of-fear (ROF) induction through reinstatement (a model for adversity-induced relapse; day 2)...
July 19, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27428089/pain-related-stress-in-the-neonatal-intensive-care-unit-and-salivary-cortisol-reactivity-to-socio-emotional-stress-in-3-month-old-very-preterm-infants
#19
Livio Provenzi, Lorenzo Giusti, Monica Fumagalli, Hilarj Tasca, Francesca Ciceri, Giorgia Menozzi, Fabio Mosca, Francesco Morandi, Renato Borgatti, Rosario Montirosso
Very preterm (VPT) infants are hospitalized in the Neonatal Intensive Care Unit (NICU) and exposed to varying levels of skin-breaking procedures (pain-related stress), even in absence of severe clinical conditions. Repeated and prolonged pain exposure may alter hypothalamic-pituitary-adrenal (HPA) axis reactivity in VPT infants. During the post-discharge period, altered HPA axis reactivity has been documented in response to non-social stressors, using salivary cortisol as a biomarker. However, little is known about the effects of NICU pain-related stress on subsequent HPA axis reactivity to socio-emotional stress in infants...
October 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27194629/rooming-in-to-treat-neonatal-abstinence-syndrome-improved-family-centered-care-at-lower-cost
#20
Alison Volpe Holmes, Emily C Atwood, Bonny Whalen, Johanna Beliveau, J Dean Jarvis, John C Matulis, Shawn L Ralston
BACKGROUND AND OBJECTIVE: The incidence and associated costs of neonatal abstinence syndrome (NAS) have recently risen sharply; newborns with NAS occupy 4% of NICU beds. We implemented a coordinated program for NAS including standardized protocols for scoring, medications and weaning, and a calm rooming-in environment, to improve family-centered care and to decrease both length of stay (LOS) and hospital costs. METHODS: In early 2013, a multidisciplinary quality improvement team began consecutive plan-do-study-act (PDSA) cycles...
June 2016: Pediatrics
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