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https://www.readbyqxmd.com/read/28110057/real-life-outcomes-for-patients-with-asthma-prescribed-spacers-for-use-with-either-extrafine-or-fine-particle-inhaled-corticosteroids
#1
Theresa W Guilbert, Gene Colice, Jonathan Grigg, Wim van Aalderen, Richard J Martin, Elliot Israel, Dirkje S Postma, Nicolas Roche, Wanda Phipatanakul, Elizabeth V Hillyer, Jennifer M Evans, Myrna B Dolovich, David B Price
BACKGROUND: Spacers are often used with pressurized metered-dose inhalers (pMDIs) to eliminate the need for coordinating inhalation with actuation. OBJECTIVE: To investigate the real-life effectiveness of spacers prescribed for use with either extrafine- or fine-particle inhaled corticosteroids (ICSs). METHODS: This historical matched cohort study examined anonymous medical record data over 2 years (1-year baseline, 1-year outcome) for patients with asthma aged 12 to 80 years initiating ICSs by pMDI with or without prescribed spacer...
January 18, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28109212/two-structure-thermodynamics-for-the-tip4p-2005-model-of-water-covering-supercooled-and-deeply-stretched-regions
#2
John W Biddle, Rakesh S Singh, Evan M Sparano, Francesco Ricci, Miguel A González, Chantal Valeriani, José L F Abascal, Pablo G Debenedetti, Mikhail A Anisimov, Frédéric Caupin
One of the most promising frameworks for understanding the anomalies of cold and supercooled water postulates the existence of two competing, interconvertible local structures. If the non-ideality in the Gibbs energy of mixing overcomes the ideal entropy of mixing of these two structures, a liquid-liquid phase transition, terminated at a liquid-liquid critical point, is predicted. Various versions of the "two-structure equation of state" (TSEOS) based on this concept have shown remarkable agreement with both experimental data for metastable, deeply supercooled water and simulations of molecular water models...
January 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28107774/risk-factors-for-trachelectomy-following-supracervical-hysterectomy
#3
Ziv Tsafrir, Joelle Aoun, Eleni Papalekas, Andrew Taylor, Lauren Schiff, Evan Theoharis, David Eisenstein
We identified risk factors for trachelectomy after supracervical hysterectomy (SCH) due to persistence of symptoms MATERIAL AND METHODS: A retrospective case-control study in a university affiliated hospital. Seventeen patients who underwent a trachelectomy following SCH for nonmalignant indications between June 2002 and October 2014 were compared 68 randomly selected patients (controls) who underwent a SCH within the same time period. Demographics and clinical characteristics were compared between the study and control groups...
January 20, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28107747/diversity-of-dna-viruses-in-effluents-of-membrane-bioreactors-in-traverse-city-mi-usa-and-la-grande-motte-france
#4
Evan O'Brien, Mariya Munir, Terence Marsh, Marc Heran, Geoffroy Lesage, Volodymyr V Tarabara, Irene Xagoraraki
This study assesses diversity of DNA viruses in the effluents of two membrane bioreactor (MBR) wastewater treatment plants (WWTPs): an MBR in the United States and an MBR in France. Viral diversity of these effluents is compared to that of a conventional activated sludge WWTP in the U.S. Diversity analysis indicates Herpesvirales to be the most abundant order of potentially pathogenic human DNA viruses in wastewater treated effluent in all utilities. Other potentially pathogenic human viruses detected include Adenoviridae, Parvoviridae, and Polyomaviridae...
January 8, 2017: Water Research
https://www.readbyqxmd.com/read/28106760/asymmetric-total-synthesis-of-ieodomycin-b
#5
Shuangjie Lin, Jianting Zhang, Zhibin Zhang, Tianxiang Xu, Shuangping Huang, Xiaoji Wang
Ieodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine Bacillus species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-trans-dihydroxyl at C-3 and C-5 positions via a Crimmins-modified Evans aldol reaction and a chelation-controlled Mukaiyama aldol reaction of a p-methoxybenzyl-protected aldehyde, as well as the generation of a lactone ring in a deprotection-lactonization one-pot reaction...
January 18, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28105974/baseline-practices-for-the-application-of-genomic-data-supporting-regulatory-food-safety
#6
Dominic Lambert, Arthur Pightling, Emma Griffiths, Gary Van Domselaar, Peter Evans, Sharon Berthelet, Duncan Craig, P Scott Chandry, Robert Stones, Fiona Brinkman, Alexandre Angers-Loustau, Joachim Kreysa, Weida Tong, Burton Blais
The application of new data streams generated from next-generation sequencing (NGS) has been demonstrated for food microbiology, pathogen identification, and illness outbreak detection. The establishment of best practices for data integrity, reproducibility, and traceability will ensure reliable, auditable, and transparent processes underlying food microbiology risk management decisions. We outline general principles to guide the use of NGS data in support of microbiological food safety. Regulatory authorities across intra- and international jurisdictions can leverage this effort to promote the reliability, consistency, and transparency of processes used in the derivation of genomic information for regulatory food safety purposes, and to facilitate interactions and the transfer of information in the interest of public health...
January 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28105634/does-radiologic-response-correlate-to-pathologic-response-in-patients-undergoing-neoadjuvant-therapy-for-borderline-resectable-pancreatic-malignancy
#7
Brent T Xia, Baojin Fu, Jiang Wang, Young Kim, S Ameen Ahmad, Vikrom K Dhar, Nick C Levinsky, Dennis J Hanseman, David A Habib, Gregory C Wilson, Milton Smith, Olugbenga O Olowokure, Jordan Kharofa, Ali H Al Humaidi, Kyuran A Choe, Daniel E Abbott, Syed A Ahmad
BACKGROUND AND OBJECTIVES: In patients with borderline resectable pancreas cancers, clinicians frequently consider radiographic response as the primary driver of whether patients should be offered surgical intervention following neoadjuvant therapy (NT). We sought to determine any correlation between radiographic and pathologic response rates following NT. METHODS: Between 2005 and 2015, 38 patients at a tertiary care referral center underwent NT followed by pancreaticoduodenectomy for borderline resectable pancreas cancer...
January 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28104671/lack-of-association-of-cd55-receptor-genetic-variants-and-severe-malaria-in-ghanaian-children
#8
Kathrin Schuldt, Christa Ehmen, Juergen Sievertsen, Jennifer Evans, Juergen May, Daniel Ansong, Birgit Muntau, Gerd Ruge, Christian Timmann, Tsiri Agbenyega, Rolf D Horstmann, Thorsten Thye
In a recent report the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of the most severe form of malaria. As this invasion process represents a critical step during the infection with the parasite, it was hypothesized that genetic variants in the gene could affect severe malaria susceptibility. We performed high-resolution variant discovery of rare and common genetic variants in the human CD55 gene. Association testing of these variants in over 1 700 severe malaria cases and unaffected control individuals from a malaria-endemic Ashanti Region in Ghana, West Africa, were performed on the basis of single variants, combined rare variant analyses, and reconstructed haplotypes...
January 18, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28104429/using-lysine-adducts-of-human-serum-albumin-to-investigate-the-disposition-of-exogenous-formaldehyde-in-human-blood
#9
Luca G Regazzoni, Hasmik Grigoryan, Zhiying Ji, Xi Chen, Sarah I Daniels, Deyin Huang, Sylvia Sanchez, Naijun Tang, Fenna C M Sillé, Anthony T Iavarone, Evan R Williams, Luoping Zhang, Stephen M Rappaport
Formaldehyde is a human carcinogen that readily binds to nucleophiles, including proteins and DNA. To investigate whether exogenous formaldehyde produces adducts in extracellular fluids, we characterized modifications to human serum albumin (HSA) following incubation of whole blood, plasma, and saliva with formaldehyde at concentrations of 1, 10 and 100μM. The only HSA locus that showed the presence of formaldehyde modifications was Lys199. A N(6)-Lys adduct with added mass of 12Da, representing a putative intramolecular crosslink, was detected in biological fluids that had been incubated with formaldehyde but not in control fluids...
January 16, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28102483/integrating-patient-concerns-into-parkinson-s-disease-management
#10
REVIEW
Shen-Yang Lim, Ai Huey Tan, Susan H Fox, Andrew H Evans, Soon Chai Low
Parkinson's disease (PD) is a complex motor and non-motor disorder and management is often challenging. In this review, we explore emerging approaches to improve the care of patients, drawing from the literature regarding patient-centred care, patient and caregiver perspectives and priorities, gaps in knowledge among patients and caregivers and the need for accurate information, individual variability in disease manifestations, prognostication of disease course, new developments in health technologies and personalized medicine, specialty care, pharmacological and non-pharmacological management, financial burden, lifestyle and work-related issues, support groups and palliative care...
January 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28102159/x-rays-for-acute-knee-injuries-pre-and-post-pittsburgh-decision-rules-implementation-a-district-general-hospital-experience
#11
Saad R El Ashry, Tarek A El Gamal, Sudhakar R Challagundla, Chara A Ntala, Ahmed M Nagy, Evan O Crane
BACKGROUND: We wanted to assess the number of unnecessary radiographs done for acute knee injury patients and the accuracy of the Pittsburgh decision rules. MATERIAL AND METHODS: A retrospective observational study was done to look at the acute knee injury patients presented to a district general hospital Accident and Emergency Department from August 2011 till August 2013. We assessed the following parameters: sex, age, mechanism of injury, weight-bearing status and incidence of fractures in patients subjected to plain radiograph...
October 28, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28101921/effects-of-shifts-in-food-reinforcement-context-on-rats-consumption-of-concurrently-available-water-or-sucrose-solution
#12
Chad M Galuska, Leslie E Sawyer
The purpose of this study was to investigate the effects of signaled transitions from relatively rich to lean conditions of food reinforcement on drinking concurrently available water or sucrose-sweetened water in rats. Past research demonstrated that these negative incentive shifts produce behavioral disruption in the form of extended pausing on fixed-ratio schedules. Four male Long-Evans rats operated on a two-component multiple fixed-ratio fixed-ratio schedule. In one manipulation, the ratio was held constant and the components arranged either a large six-pellet reinforcer (rich) or small one-pellet reinforcer (lean)...
January 2017: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/28101795/locally-advanced-pancreatic-cancer-successfully-treated-by-distal-pancreatectomy-with-celiac-axis-resection-dp-car-after-s-1-with-radiation-therapy-followed-by-gemcitabine-nab-paclitaxel-therapy-a-case-report
#13
Kyohei Ariake, Fuyuhiko Motoi, Masamichi Mizuma, Keigo Murakami, Tatsuyuki Takadate, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Kei Nakagawa, Naoaki Sakata, Takanori Morikawa, Shimpei Maeda, Takeshi Naitoh, Shinichi Egawa, Michiaki Unno
BACKGROUND: The prognosis for pancreatic cancer remains dismal because many patients are diagnosed with unresectable cancer at the initial diagnosis. Recently, conversion surgery was reported as an effective treatment for initially unresectable pancreatic cancer with a favorable response to non-surgical treatment lasting over 240 days. Here, we describe a case of locally advanced pancreatic cancer (LAPC) successfully resected after treatment with S-1 and radiation followed by gemcitabine/nab-paclitaxel therapy...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28101674/posterior-tail-development-in-the-salamander-eurycea-cirrigera-exploring-cellular-dynamics-across-life-stages
#14
Janet L Vaglia, Chet Fornari, Paula K Evans
During embryogenesis, the body axis elongates and specializes. In vertebrate groups such as salamanders and lizards, elongation of the posterior body axis (tail) continues throughout life. This phenomenon of post-embryonic tail elongation via addition of vertebrae has remained largely unexplored, and little is known about the underlying developmental mechanisms that promote vertebral addition. Our research investigated tail elongation across life stages in a non-model salamander species, Eurycea cirrigera (Plethodontidae)...
January 18, 2017: Development Genes and Evolution
https://www.readbyqxmd.com/read/28101605/surviving-sepsis-campaign-international-guidelines-for-management-of-sepsis-and-septic-shock-2016
#15
Andrew Rhodes, Laura E Evans, Waleed Alhazzani, Mitchell M Levy, Massimo Antonelli, Ricard Ferrer, Anand Kumar, Jonathan E Sevransky, Charles L Sprung, Mark E Nunnally, Bram Rochwerg, Gordon D Rubenfeld, Derek C Angus, Djillali Annane, Richard J Beale, Geoffrey J Bellinghan, Gordon R Bernard, Jean-Daniel Chiche, Craig Coopersmith, Daniel P De Backer, Craig J French, Seitaro Fujishima, Herwig Gerlach, Jorge Luis Hidalgo, Steven M Hollenberg, Alan E Jones, Dilip R Karnad, Ruth M Kleinpell, Younsuk Koh, Thiago Costa Lisboa, Flavia R Machado, John J Marini, John C Marshall, John E Mazuski, Lauralyn A McIntyre, Anthony S McLean, Sangeeta Mehta, Rui P Moreno, John Myburgh, Paolo Navalesi, Osamu Nishida, Tiffany M Osborn, Anders Perner, Colleen M Plunkett, Marco Ranieri, Christa A Schorr, Maureen A Seckel, Christopher W Seymour, Lisa Shieh, Khalid A Shukri, Steven Q Simpson, Mervyn Singer, B Taylor Thompson, Sean R Townsend, Thomas Van der Poll, Jean-Louis Vincent, W Joost Wiersinga, Janice L Zimmerman, R Phillip Dellinger
OBJECTIVE: To provide an update to "Surviving Sepsis Campaign Guidelines for Management of Sepsis and Septic Shock: 2012". DESIGN: A consensus committee of 55 international experts representing 25 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict-of-interest (COI) policy was developed at the onset of the process and enforced throughout. A stand-alone meeting was held for all panel members in December 2015...
January 18, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28101348/evans-blue-mediated-white-light-detection-of-non-muscle-invasive-bladder-cancer-a-preclinical-feasibility-and-safety-study-using-a-rat-bladder-urothelial-cell-carcinoma-model
#16
Sanne Elsen, Evelyne Lerut, Frank Van Der Aa, Ben Van Cleynenbreugel, Hendrik Van Poppel, Peter De Witte
Photodynamic diagnosis (PDD) improves the detection of non-muscle-invasive bladder cancer (NMIBC). However, white-light (WL) cystoscopy remains the technique routinely used in urological clinics. A more cost-effective but equally performant alternative to PDD may encompass the use of an intense tumoritropic dye in combination with WL cystoscopy. Using a preclinical setting, we investigated the practical aspects of the use of Evans blue (EB) dye for the possible future detection of NMIBC using WL cystoscopy...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28100819/vertically-transmitted-rhabdoviruses-are-found-across-three-insect-families-and-have-dynamic-interactions-with-their-hosts
#17
Ben Longdon, Jonathan P Day, Nora Schulz, Philip T Leftwich, Maaike A de Jong, Casper J Breuker, Melanie Gibbs, Darren J Obbard, Lena Wilfert, Sophia C L Smith, John E McGonigle, Thomas M Houslay, Lucy I Wright, Luca Livraghi, Luke C Evans, Lucy A Friend, Tracey Chapman, John Vontas, Natasa Kambouraki, Francis M Jiggins
A small number of free-living viruses have been found to be obligately vertically transmitted, but it remains uncertain how widespread vertically transmitted viruses are and how quickly they can spread through host populations. Recent metagenomic studies have found several insects to be infected with sigma viruses (Rhabdoviridae). Here, we report that sigma viruses that infect Mediterranean fruit flies (Ceratitis capitata), Drosophila immigrans, and speckled wood butterflies (Pararge aegeria) are all vertically transmitted...
January 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28100572/pain-in-the-neck
#18
Zaid Makzal, Alison Evans, Kavitha Masilamani
No abstract text is available yet for this article.
January 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28100271/evaluation-of-three-sample-preparation-methods-for-the-direct-identification-of-bacteria-in-positive-blood-cultures-by-maldi-tof
#19
Hannah Tanner, Jason T Evans, Savita Gossain, Abid Hussain
BACKGROUND: Patient mortality is significantly reduced by rapid identification of bacteria from sterile sites. MALDI-TOF can identify bacteria directly from positive blood cultures and multiple sample preparation methods are available. We evaluated three sample preparation methods and two MALDI-TOF score cut-off values. Positive blood culture bottles with organisms present in Gram stains were prospectively analysed by MALDI-TOF. Three lysis reagents (Saponin, SDS, and SepsiTyper lysis bufer) were applied to each positive culture followed by centrifugation, washing and protein extraction steps...
January 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28099706/factors-influencing-hpv-vaccine-delivery-by-healthcare-professionals-at-public-health-posts-in-s%C3%A3-o-paulo-brazil
#20
Daniella Figueroa-Downing, Maria Luiza Baggio, Misha L Baker, Ellen Dias De Oliveira Chiang, Luisa L Villa, Jose Eluf Neto, Dabney P Evans, Robert A Bednarczyk
OBJECTIVE: To assess the association between Brazilian healthcare providers' characteristics and their knowledge, perceptions, and practices regarding the HPV vaccine. METHODS: An observational cross-sectional study was conducted at five public health posts in São Paulo between July 28 and August 8, 2014. Healthcare professionals directly involved in patient care were asked to complete a written survey. Factors associated with routine verification of HPV vaccination status were evaluated using Poisson regression...
January 2017: International Journal of Gynaecology and Obstetrics
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