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Nagihan Cevher Binici, Zehra Topal, Nuran Demir Samurcu, Mehmet Akif Cansız, Uğur Savcı, Yusuf Öztürk, Gonca Özyurt, Ali Evren Tufan
No abstract text is available yet for this article.
March 2018: Journal of Child and Adolescent Psychopharmacology
Ujjwal Maulik, Sagnik Sen, Saurav Mallik, Sanghamitra Bandyopadhyay
BACKGROUND: Study of epigenetics is currently a high-impact research topic. Multi stage methylation is also an area of high-dimensional prospect. In this article, we provide a new study (intra and inter-species study) on brain tissue between human and rhesus on two methylation cytosine variants based data-profiles (viz., 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) samples) through TF-miRNA-gene network based module detection. RESULTS: First of all, we determine differentially 5hmC methylated genes for human as well as rhesus for intra-species analysis, and differentially multi-stage methylated genes for inter-species analysis...
January 22, 2018: BMC Genetics
José Gutiérrez Fernández
Schizophrenia is a disease of unknown etiology. Many authors have studied its association with infections. By meta-analysis viruses are the most studied agents, relationship with the Borna virus and human endogenous retrovirus W. Also, C. pneumoniae and C. psittaci DNA in blood are more common in patients. Finally, there is association with parasitism by T. gondii, despite the existence of publication bias. Serologically, in our environment, anti-Toxoplasma IgG may be a risk factor related to schizophrenia, and may have potential value for better diagnosis and prevention...
2012: Anales de la Real Academia Nacional de Medicina
B W Palmer, D V Jeste
A review of literature on the neurodevelopmental origins of schizophemia is presented, with particular attention to neurodevelopmental processes in late-onset schizophemia. Definitions of the term "neurodevelopmental" as used in schizophernia literature are first provided. Next, evidence for the developmental origins of the neuropathology in schizophemia is reviewed. This evidence includes studies of the associations between schizophemia and neurodevelopmental brain aberrations, minor physical anomalies, obstetric complications, prenatal viral exposure, childhood neuromotor abnormalities, and pandysmaturation...
January 1996: Indian Journal of Psychiatry
Aiden P Corvin
The major mental disorders, schizophrenia and bipolar disorder are substantially heritable. Recent genomic studies have identified a small number of common and rare risk genes contributing to both disorders and support epidemiological evidence that genetic susceptibility overlaps between them. Prompted by the question of whether risk genes cluster in specific molecular pathways or implicate discrete mechanisms we and others have developed hypothesis-free methods of investigating genome-wide association datasets at a pathway-level...
October 2010: Cell Adhesion & Migration
Mohammed A Kashem, Rahnuma Ummehany, Wataru Ukai, Eri Hashimoto, Toshikazu Saito, Iain S Mcgregor, Izuru Matsumoto
Neural stem cells (NSCs) play a crucial role in the development and maturation of the central nervous system. Recently studies suggest that antipsychotic drugs regulate the activities of NSCs. However, the molecular mechanisms underlying antipsychotic-induced changes of the activity of NSCs, particularly protein expression, are still unknown. We studied the growth and protein expression in haloperidol (HD) and risperidone (RS) treated rat NSCs. The treatment with RS (3microM) or HD (3microM) had no effect on morphology of NSCs after 24h, but significantly promotes or inhibits the differentiation of NSCs after a 96h of treatment...
December 2009: Neurochemistry International
Barbara L Schwartz, Cherie L Marvel, Amy Drapalski, Richard B Rosse, Stephen I Deutsch
INTRODUCTION: There is currently substantial literature to suggest that patients with schizophrenia are impaired on many face-processing tasks. This study investigated the specific effects of configural changes on face recognition in groups of schizophrenia patients. METHODS: In Experiment 1, participants identified facial expressions in upright faces and in faces inverted from their upright orientation. Experiments 2 and 3 examined recognition memory for faces and other non-face objects presented in upright and inverted orientations...
February 2002: Cognitive Neuropsychiatry
Ross J. Baldessarini, Trisha Suppes, Leonardo Tondo
Recent clinical research strongly suggests that there is a period of elevated risk of morbidity in the several months following abrupt discontinuation or reduction of doses in maintenance treatments commonly used in the contemporary management of chronic or recurring major psychiatric disorders. This risk is best quantified for the discontinuation of lithium therapy in bipolar disorders, in which risk of mania, depression, and suicidal behavior may rise. Similar symptomatic risks are well known after stopping antianxiety agents, and probably also follow rapid removal of oral neuroleptics in schizophenia and antidepressants in major depression...
July 1996: American Journal of Therapeutics
H Lôo, E Zarifian, J F Allilaire
No abstract text is available yet for this article.
January 1, 1980: La Revue du Praticien
K W Piotrowski, D Losacco, S B Guze
A study of 50 consecutive individuals referred for pretrial psychiatric examination, presumably because of previous psychiatric hospitalization (82 percent), indicated that antisocial personality, alcoholism, or drug dependence was present in 80 percent. Schizophrenia or bipolar affective disorder was seen in about a third of the subjects, usually associated as well, however, with antisocial personality, alcoholism, or drug dependence. There were no significant differences in index crime between those with or without schizophenia bipolar affective disorder...
May 1976: Diseases of the Nervous System
J Gerevich, G Ungvári, I Karczag
In discussing 2 patients, the authors point out that a study of spontaneous drawings by psychotics can be of considerable diagnostic importance in clinical practice. The clear structure of the drawings threw doubt on the diagnosis of schizophrenia in the case of the first patient who could be classified in the schizophenia spectrum on the basis of the formal symptoms. In the case of the second patient, where th clinical picture suggested different diagnosis, the drawings represent the 'ossified' essence of the experience and behavior symptoms and thus provided an objective basis for nosological classification...
1979: Confinia Psychiatrica. Borderland of Psychiatry. Grenzgebiete der Psychiatrie. les Confins de la Psychiatrie
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