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https://www.readbyqxmd.com/read/28543185/iron-oxide-nanoparticles-decrease-nuclear-fractal-dimension-of-buccal-epithelial-cells-in-a-time-dependent-manner
#1
D Nikolovski, S Dugalic, I Pantic
In this paper, we present results that iron oxide nanoparticles (IONPs) induce time-dependent structural changes in nuclei of buccal epithelial cells. The cells were treated with magnetite, Fe3 O4 nanoparticles (spherical shape, diameter 80-100 nanometres). The digital micrographs of the nuclei were made in 3 different time points: 15, 30 and 60 min after the treatment with IONPs, as well as in the control cells. A total of 120 nuclear structures (30 per sample) were analysed. Fractal analysis of nuclei was done in ImageJ software of the National Institutes of Health, (Bethesda, MD, USA)...
May 23, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28542307/the-mouse-char10-locus-regulates-severity-of-pyruvate-kinase-deficiency-and-susceptibility-to-malaria
#2
Aurélie Laroque, Gundula Min-Oo, Mifong Tam, Prem Ponka, Mary M Stevenson, Philippe Gros
Pyruvate kinase (PKLR) deficiency protects mice and humans against blood-stage malaria. Although mouse strain AcB62 carries a malaria-protective PklrI90N genetic mutation, it is phenotypically susceptible to blood stage malaria induced by infection with Plasmodium chabaudi AS, suggesting a genetic modifier of the PklrI90N protective effect. Linkage analysis in a F2 cross between AcB62 (PklrI90N) and another PK deficient strain CBA/Pk (PklrG338D) maps this modifier (designated Char10) to chromosome 9 (LOD = 10...
2017: PloS One
https://www.readbyqxmd.com/read/28542246/a-drastic-superoxide-dependent-oxidative-stress-is-prerequisite-for-the-down-regulation-of-irp1-insights-from-studies-on-sod1-deficient-mice-and-macrophages-treated-with-paraquat
#3
Anna Milczarek, Rafał R Starzyński, Agnieszka Styś, Aneta Jończy, Robert Staroń, Agnieszka Grzelak, Paweł Lipiński
Iron regulatory protein 1 (IRP1) is a cytosolic bifunctional [4Fe-4S] protein which exhibits aconitase activity or binds iron responsive elements (IREs) in untranslated regions of specific mRNA encoding proteins involved in cellular iron metabolism. Superoxide radical (O2.-) converts IRP1 from a [4Fe-4S] aconitase to a [3Fe-4S] "null" form possessing neither aconitase nor trans-regulatory activity. Genetic ablation of superoxide dismutase 1 (SOD1), an antioxidant enzyme that acts to reduce O2.- concentration, revealed a new O2...
2017: PloS One
https://www.readbyqxmd.com/read/28540947/the-role-of-iron-nitrides-in-the-fe-n-c-catalysis-system-towards-the-oxygen-reduction-reaction
#4
Min Wang, Yushi Yang, Xiaobo Liu, Zonghua Pu, Zongkui Kou, Peipei Zhu, Shichun Mu
Fe-N-C series catalysts are always attractive for their high catalytic activity towards the oxygen reduction reaction (ORR). However, they usually consist of various components such as iron nitrides, metallic iron, iron carbides, N-doped carbon and Fe-N4 moieties, leading to controversial contributions of these components to the catalysis of the ORR, especially iron nitrides. In this work, to investigate the function of iron nitrides, FexN nanoparticles (NPs) embedded in mesoporous N-doped carbon without Fe-N4 moieties are designed and constructed by a simple histidine-assisted method...
May 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28540740/the-incomplete-glutathione-puzzle-just-guessing-at-numbers-and-figures
#5
Marcel Deponte
SIGNIFICANCE: Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It supposably comprises (i) the reduction of disulfides, hydroperoxides, sulfenic acids and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics and heavy metals, and (iii) the synthesis of eicosanoids, steroids and iron-sulfur clusters. Furthermore, glutathione affects oxidative protein folding and redox signaling. Here, I review the relevance of glutathione-dependent pathways with an emphasis on quantitative data...
May 25, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28539274/the-analgesia-efficiency-of-ultrasmall-magnetic-iron-oxide-nanoparticles-in-mice-chronic-inflammatory-pain-model
#6
Ping-Ching Wu, Hung-Tsung Hsiao, Ya-Chi Lin, Dar-Bin Shieh, Yen-Chin Liu
Few studies have investigated the effects of iron oxide nanoparticles (NPs) on analgesia. We developed inflammatory pain models via complete Freund's adjuvant injection over the hind paw in CD1 mice. Various doses of magnetite (Fe3O4) NPs were injected into the paw. Analgesia behavior was checked with von Frey microfilament and thermal irradiation measurements. Paw skin tissues were harvested at the maximal analgesia time point. The presence of activated white cells (CD68, myeloperoxidase) and free radical (reactive oxygen species, ROS) production were also checked...
May 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28533164/a-novel-iron-ii-preferring-dopamine-agonist-chelator-d-607-significantly-suppresses-%C3%AE-syn-and-mptp-induced-toxicities-in-vivo
#7
Banibrata Das, Subramanian Rajagopalan, Gnanada S Joshi, Liping Xu, Dan Luo, Julie K Andersen, Sokol V Todi, Aloke K Dutta
Here, we report the characterization of a novel hybrid D2/D3 agonist and iron (II) specific chelator, D-607, as a multi-target-directed ligand against Parkinson's disease (PD). In our previously published report, we showed that D-607 is a potent agonist of dopamine (DA) D2/D3 receptors, exhibits efficacy in a reserpinized PD animal model and preferentially chelates to iron (II). As further evidence of its potential as a neuroprotective agent in PD, the present study reveals D-607 to be protective in neuronal PC12 cells against 6-OHDA toxicity...
May 19, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28532274/formation-of-iron-oxide-pd-hybrid-nanostructures-with-enhanced-peroxidase-like-activity-and-catalytic-reduction-of-4-nitrophenol
#8
Jing Li, Junhui Cai, Huimin Jia, Lixia Zhang, Yan Lei, Weiwei He, Jun-Jie Yin
Iron oxide/Pd hybrid nanostructures with controllable Pd loading from 0.05 to 1.0 (calculated as Pd/Fe molar ratio) have been synthesized by chemical reduction of Pd(2+) on iron oxide particles. The combination of iron oxide and Pd exhibits enhanced peroxidase-like activity and catalytic activity toward reduction of 4-nitrophenol. The catalytic enhancements were found to be dependent on the Pd loading amount as well as the synergistic effect between iron oxide and Pd. These results suggest that iron oxide with unique surface chemical state can be an active supporter and suggest an effective way to design superior hybrid nanostructures for catalytic applications...
May 22, 2017: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/28530105/effect-of-humic-acid-on-the-removal-of-chromium-vi-and-the-production-of-solids-in-iron-electrocoagulation
#9
Chao Pan, Lyndsay D Troyer, Peng Liao, Jeffrey G Catalano, Wenlu Li, Daniel E Giammar
Iron-based electrocoagulation can be highly effective for Cr(VI) removal from water supplies. However, the presence of humic acid (HA) inhibited the rate of Cr(VI) removal in electrocoagulation, with the greatest decreases in Cr(VI) removal rate at higher pH. This inhibition was probably due to the formation of Fe(II) complexes with HA that are more rapidly oxidized than uncomplexed Fe(II) by dissolved oxygen, making less Fe(II) available for reduction of Cr(VI). Close association of Fe(III), Cr(III), and HA in the solid products formed during electrocoagulation influenced the fate of both Cr(III) and HA...
May 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28527389/dynamics-of-dissolved-organic-matter-in-riverine-sediments-affected-by-weir-impoundments-production-benthic-flux-and-environmental-implications
#10
Meilian Chen, Sung-Han Kim, Heon-Jae Jung, Jung-Ho Hyun, Jung Hyun Choi, Hyo-Jin Lee, In-Ae Huh, Jin Hur
In order to understand the characteristics and dynamics of dissolved organic matter (DOM) in the sediment of rivers affected by impoundments, we examined the vertical profiles and the benthic fluxes of DOM in four different core sediments located at upstream sites of weirs in major rivers of South Korea. In three out of four sites, exponential accumulation of dissolved organic carbon (DOC) with depth was observed with the signature of seasonal variability. Except for the site displaying a below-detection limit of Fe(II), the general accumulation trends of DOC with depth was concurrent with the increases of Fe(II) and NH4(+) and the decrease of PO4(3-), signifying a close linkage of the DOM dynamics with anaerobic respiration via iron reduction, an important early diagenesis pathway...
May 12, 2017: Water Research
https://www.readbyqxmd.com/read/28527388/abiotic-transformation-of-hexabromocyclododecane-by-sulfidated-nanoscale-zerovalent-iron-kinetics-mechanism-and-influencing-factors
#11
Dan Li, Xifen Zhu, Yin Zhong, Weilin Huang, Ping'an Peng
Recent studies showed that sulfidated nanoscale zerovalent iron (S-nZVI) is a better reducing agent than nanoscale zerovalen iron (nZVI) alone for reductive dechlorination of several organic solvents such as trichloroethylene (TCE) due to the catalytic role of iron sulfide (FeS). We measured the rates of transformation of hexabromocyclododecane (HBCD) by S-nZVI and compared them to those by FeS, nZVI, and reduced sulfur species. The results showed that: i) HBCD (20 mg L(-1)) was almost completely transformed by S-nZVI (0...
May 9, 2017: Water Research
https://www.readbyqxmd.com/read/28527339/selective-removal-of-toxic-cr-vi-from-aqueous-solution-by-adsorption-combined-with-reduction-at-a-magnetic-nanocomposite-surface
#12
Nazia H Kera, Madhumita Bhaumik, Kriveshini Pillay, Suprakas Sinha Ray, Arjun Maity
The adsorption of toxic hexavalent chromium (Cr(VI)) and its reduction to trivalent chromium (Cr(III)) are important processes for the treatment of industrial wastewater. Conducting polymers can adsorb and reduce Cr(VI) to less toxic Cr(III) but have low adsorption capacities due to agglomeration of particles and are difficult to separate from treated water. In this study, magnetic polypyrrole (PPy)-polyaniline (PANI)/iron oxide (Fe3O4) nanocomposite was synthesized for the selective removal of Cr(VI) in aqueous solution...
May 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28522841/near-infrared-heptamethine-cyanine-based-iron-oxide-nanoparticles-for-tumor-targeted-multimodal-imaging-and-photothermal-therapy
#13
Sejy Lee, Reju George Thomas, Myeong Ju Moon, Hyeong Ju Park, In-Kyu Park, Byeong-Il Lee, Yong Yeon Jeong
Near-infrared fluorescent (NIRF) imaging modality holds great promise for tumor detection and offers several advantages of bioimaging, such as high tissue penetration with less background scattering. The disadvantage of NIRF bioimaging is that it has very low spatial resolution. Thus, the combination of NIRF with magnetic resonance imaging (MRI) is a good option because MRI can provide anatomical information with a higher resolution. Heptamethine cyanine dye (MHI-148) has been reported to have tumor-targeting capability which was used here as the NIRF agent...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521711/mini-heme-proteins-designability-of-structure-and-diversity-of-functions
#14
Jagdish Rai
Natural heme proteins may have heme bound to poly-peptide chain as a cofactor via non-covalent forces or heme as a prosthetic group may be covalently bound to the proteins. Nature has used porphyrins in diverse functions like electron transfer, oxidation, reduction, ligand binding, photosynthesis, signaling, etc. by modulating its properties through diverse protein matrices. Synthetic chemists have tried to utilize these molecules in equally diverse industrial and medical applications due to their versatile electro-chemical and optical properties...
May 15, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28515572/a-family-of-fe-n-c-oxygen-reduction-electrocatalysts-for-microbial-fuel-cell-mfc-application-relationships-between-surface-chemistry-and-performances
#15
Carlo Santoro, Alexey Serov, Rohan Gokhale, Santiago Rojas-Carbonell, Lydia Stariha, Jonathan Gordon, Kateryna Artyushkova, Plamen Atanassov
Different iron-based cathode catalysts have been studied for oxygen reduction reaction (ORR) in neutral media and then applied into microbial fuel cells (MFC). The catalysts have been synthesized using sacrificial support method (SSM) using eight different organic precursors named Niclosamide, Ricobendazole, Guanosine, Succinylsulfathiazole, Sulfacetamide, Quinine, Sulfadiazine and Pyrazinamide. Linear Sweep Voltammetry (LSV) curves were obtained for the catalysts using a O2 saturated in 0.1 M potassium phosphate buffer and 0...
May 15, 2017: Applied Catalysis. B, Environmental
https://www.readbyqxmd.com/read/28515324/the-diferric-tyrosyl-radical-cluster-of-ribonucleotide-reductase-and-cytosolic-iron-sulfur-clusters-have-distinct-and-similar-biogenesis-requirements
#16
Haoran Li, Martin Stümpfig, Caiguo Zhang, Xiuxiang An, JoAnne Stubbe, Roland Lill, Mingxia Huang
How each metalloprotein assembles the correct metal at the proper binding site presents challenges to the cell. The di-iron enzyme ribonucleotide reductase (RNR) uses a diferric-tyrosyl radical (Fe(III)2-Y·) cofactor to initiate nucleotide reduction. Assembly of this cofactor requires O2, Fe(II), and a reducing equivalent. Recent studies show that RNR cofactor biosynthesis shares the same source of iron, in the form of [2Fe-2S]-GSH2 from the monothiol glutaredoxin Grx3/4, and the same electron source, in the form of the Dre2-Tah18 electron transfer chain, with the cytosolic iron-sulfur protein assembly (CIA) machinery required for maturation of [4Fe-4S] clusters in cytosolic and nuclear proteins...
May 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28513663/reductive-activation-of-o2-by-a-bioinspired-fe-complex-for-catalytic-epoxidation-reactions
#17
Kundan K Singh, Sayam Sen Gupta
Aerobic epoxidation of olefins catalyzed by iron complexes without the use of a sacrificial coreductant is unknown. We report the reductive activation of O2 by a bioinspired [(bTAML)Fe(III)(H2O)](-) (1) complex to catalyze the epoxidation of alkenes with TONs of up to 80. Spectroscopic and kinetic evidence indicates the involvement of Fe(V)(O) as the active oxidant during the reaction.
May 17, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28513137/hierarchical-porous-carbon-doped-with-iron-nitrogen-sulfur-for-efficient-oxygen-reduction-reaction
#18
Issa Kone, Ao Xie, Yang Tang, Yu Chen, Jia Liu, Yongmei Chen, Yanzhi Sun, Xiao Jin Yang, Pingyu Wan
Hierarchical porous Fe/N/S-doped carbon with dominance of graphitic nitrogen (FeNS/HPC) has been successfully synthesized by a facile dual-template method. FeNS/HPC shows not only macro-pores resulting from the dissolution of SiO2 template, but also abundant meso-pores were obtained after removing of the in-situ generated Fe2O3 nanoparticles on the ultra-thin (~4 nm) carbon shell of macro-pores. Moreover, micro-pores are produced during the thermal pyrolysis of carbon precursors. With respect to electrochemical performance towards oxygen reduction reaction (ORR), FeNS/HPC not only exceeds other prepared porous carbon materials completely, but also shows higher onset potential (0...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28511533/composition-morphology-and-topography-of-galvanic-coatings-fe-co-w-and-fe-co-mo
#19
Iryna Yu Yermolenko, Maryna V Ved, Nykolay D Sakhnenko, Yulya I Sachanova
Ternary coatings Fe-Co-W with an iron content of 40-55 at.%, cobalt 39-44 at.%, and tungsten 4-12 at.% and Fe-Co-Mo with an iron content of 40-55 at.%, cobalt 39-44 at.%, and tungsten 4-12 at.% were obtained by galvanostatic and pulse electrolysis on the mild steel substrate from iron(III) citrate-based electrolyte. The influence of electrolysis mode and parameters on composition of deposited alloys was studied. The competing reduction of iron and tungsten in Fe-Co-W coatings as well as the competitive deposition of iron and cobalt in Fe-Co-Mo coatings at various current densities were defined...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28509551/significance-of-the-2fe-2s-cluster-n1a-for-electron-transfer-and-assembly-of-escherichia-coli-respiratory-complex-i
#20
Katerina Dörner, Marta Vranas, Johannes Schimpf, Isabella R Straub, Jo Hoeser, Thorsten Friedrich
NADH:ubiquinone oxidoreductase, respiratory complex I, couples electron transfer from NADH to ubiquinone with proton translocation across the membrane. NADH reduces a non-covalently bound FMN and the electrons are transported further to the quinone reduction site by a 95 Å long chain of seven iron-sulfur (Fe-S) clusters. The binuclear Fe-S cluster N1a is not part of this long chain but is located in electron transfer distance on the opposite site of FMN. The relevance of N1a to the mechanism of complex I is not known...
May 16, 2017: Biochemistry
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