keyword
MENU ▼
Read by QxMD icon Read
search

iron reduction

keyword
https://www.readbyqxmd.com/read/28087888/simulated-microgravity-decreases-circulating-iron-in-rats-role-of-inflammation-induced-hepcidin-upregulation
#1
Thibault Cavey, Nicolas Pierre, Kévin Nay, Coralie Allain, Martine Ropert, Olivier Loréal, Frédéric Derbré
During spaceflight, humans exposed to microgravity exhibit an increase of iron storage and a reduction of circulating iron. Such perturbations could promote oxidative stress and anemia in astronauts. The mechanism by which microgravity modulates iron metabolism is still unknown. Herein, we hypothesized that microgravity up-regulates hepcidin, a hormone produced by the liver that is the main controller of iron homeostasis. To test this hypothesis, rats were submitted to hindlimb unloading (HU), the reference model to mimic the effects of microgravity in rodents...
January 13, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28080030/chemoselective-enzymatic-c-h-bond-amination-catalyzed-by-a-cytochrome-p450-containing-an-ir-me-pix-cofactor
#2
Pawel Dydio, Hanna M Key, Hiroki Hayashi, Douglas S Clark, John F Hartwig
Cytochrome P450 enzymes have been engineered to catalyze abiological C-H bond amination reactions, but this abiological process is limited by the low chemoselectivity for the amination of C-H bonds over competing reduction of the substrate to a sulfonamide. Here we report that P450s derived from a thermophilic organism and containing an iridium porphyrin cofactor (Ir(Me)-PIX) in place of the heme catalyze C-H bond amination reactions with high chemoselectivity for intramolecular insertion of the resulting nitrenes into C-H bonds over reduction of the azide to the sulfonamide and with broader substrate scope than that of enzymes containing iron porphyrins...
January 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28078600/net-budgetary-impact-of-ferric-citrate-as-a-first-line-phosphate-binder-for-the-treatment-of-hyperphosphatemia-a-markov-microsimulation-model
#3
Steven M Brunelli, Scott P Sibbel, David Van Wyck, Amit Sharma, Andrew Hsieh, Glenn M Chertow
Ferric citrate (FC) has demonstrated efficacy as a phosphate binder and reduces the requirements for erythropoiesis-stimulating agents (ESAs) and intravenous (IV) iron in dialysis patients. We developed a net budgetary impact model to evaluate FC vs. other phosphate binders from the vantage of a large dialysis provider. We used a Markov microsimulation model to simulate mutually referential longitudinal effects between serum phosphate and phosphate binder dose; categories of these defined health states. Health states probabilistically determined treatment attendance and utilization of ESA and IV iron...
January 11, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28077273/reevaluating-the-mechanism-of-excitation-energy-regulation-in-iron-starved-cyanobacteria
#4
Hui-Yuan S Chen, Michelle Liberton, Himadri B Pakrasi, Dariusz M Niedzwiedzki
This paper presents spectroscopic investigation of IsiA, a chlorophyll a-binding membrane protein produced by cyanobacteria grown in iron-deficient environments. IsiA, if associated with photosystem I, supports photosystem I in light harvesting by efficiently transferring excitation energy. However, if separated from photosystem I, IsiA exhibits considerable excitation quenching observed as a substantial reduction of protein-bound chlorophyll a fluorescence lifetime. Previous spectroscopic studies suggested that carotenoids are involved in excitation energy dissipation and in addition play a second role in this antenna complex by supporting chlorophyll a in light harvesting by absorbing in the spectral range inaccessible for chlorophyll a and transferring excitation to chlorophylls...
January 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28075562/evidence-for-a-di-%C3%A2%C2%B5-oxo-diamond-core-in-the-mn-iv-fe-iv-activation-intermediate-of-ribonucleotide-reductase-from-chlamydia-trachomatis
#5
Ryan J Martinie, Elizabeth J Blaesi, Carsten Krebs, J Martin Bollinger, Alexey Silakov, Christopher J Pollock
High-valent iron and manganese complexes effect some of the most challenging biochemical reactions known, including hydrocarbon and water oxidations associated with the global carbon cycle and oxygenic photosynthesis, respectively. Their extreme reactivity presents an impediment to structural characterization, but their biological importance and potential chemical utility have, nevertheless, motivated extensive efforts toward that end. Several such intermediates accumulate during activation of class I ribonucleotide reductase (RNR) β subunits, which self-assemble dimetal cofactors with stable one-electron oxidants that serve to initiate the enzyme's free-radical mechanism...
January 11, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28072525/anionic-lanthanide-mofs-as-a-platform-for-iron-selective-sensing-systematic-color-tuning-and-efficient-nanoparticle-catalysis
#6
Ya-Pan Wu, Guo-Wang Xu, Wen-Wen Dong, Jun Zhao, Dong-Sheng Li, Jian Zhang, Xianhui Bu
New porous anionic Ln-MOFs, namely, [Me2NH2][Ln(CPA)2(H2O)2] (Ln = Eu, Gd), have been prepared through the self-assembly of 5-(4-carboxy phenyl)picolinic acid (H2CPA) and lanthanide ions. They feature open anionic frameworks with 1-D hydrophilic channels and exchangeable dimethylamine ions. The Eu phase could detect Fe(3+) ions with high selectivity and sensitivity in either aqueous solution or biological condition. The ratios of lanthanide ions on this structure platform could be rationally tuned to not only achieve dichromatic emission colors with linear correlation but also attain three primary colors (RGB) and even white light with favorable correlated color temperature...
January 10, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28071817/solution-and-gas-phase-reactivity-of-me12fe8-and-related-cluster-ions
#7
Tobias Parchomyk, Konrad Koszinowski
Organoiron species are of great interest because of their possible role as intermediates in iron-catalyzed cross-coupling reactions. Recent work (J. Am. Chem. Soc. 2016, 138, 7492) has identified and structurally characterized the cluster ion Me12Fe8- as an unprecedented representative of this class of compounds. To learn more about its behavior in solution, the possible formation of related cluster ions, and their reactivity, we have performed electrospray-ionization mass spectrometric and gas-phase experiments...
January 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28071030/the-effect-of-replacing-pork-fat-of-inulin-on-the-physicochemical-and-sensory-quality-of-guinea-fowl-pate
#8
Agnieszka Latoch, Paweł Glibowski, Justyna Libera
BACKGROUND: Potentially, pâtés could be a functional food and are an important source of proteins, vitamin A, B complex vitamins and iron. Unfortunately, one problem in pâtés is the high level of animal fat, about 30%. Pâté with low-fat guinea fowl meat and animal fat replaced with inulin can result in this product being classified as a pro-health food. The objective of the present study was to determine the effect on pâté with guinea fowl meat of reducing its pork back fat content (about 1/3, 2/3 and 100%) and the adding inulin as a partial fat substitute...
July 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28070070/quantitative-determination-of-iron-ions-based-on-a-resonance-raman-rr-probe-phenanthroline
#9
Liang Wang, Yi Zhang, Yeonju Park, Lei Chen, Young Mee Jung
In this paper, we demonstrate a new promising resonance Raman (RR)-based method for the determination of Fe(3+) concentrations in aqueous solutions. Iron ions were quantified at a low concentration range by employing hydroxylamine hydrochloride as the reductant, and phenanthroline as the complexing agent, thereby reducing Fe(3+) to Fe(2+). The addition of Fe(3+) to the detection reagent resulted in a rapid color change from colorless to orange-red, together with an obvious new RR band appearing at 1459 cm(-1)...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28068063/porous-iron-tungsten-carbide-electrocatalyst-with-high-activity-and-stability-toward-oxygen-reduction-reaction-from-the-self-assisted-synthetic-mechanism-to-its-active-species-probing
#10
Li Song, Tao Wang, Yilin Wang, Hairong Xue, Xiaoli Fan, Hu Guo, Wei Xia, Hao Gong, Jianping He
We synthesized a novel non-precious metal electrocatalyst by pyrolysis of a colloid mixture consisting of tungsten source and phenolic resin, with the simultaneous addition of ferric salt. The rationally designed electrocatalyst has a unique structure, with nano-sized WC and Fe3W3C uniformly dispersed in a three-dimensional porous carbon framework. WC, which was thought difficult to produce, is successfully prepared at a relatively low temperature of about 750 oC at inert atmosphere. XRD studies demonstrate the self-assisted effect of Fe, which accelerates the formation of WC, getting around the pathway of direct carbonaceous reduction of tungsten by carbon...
January 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28063856/effectiveness-of-deferoxamine-on-ferric-chloride-induced-epilepsy-in-rats
#11
Xiang Zou, Shize Jiang, Zehan Wu, Yimin Shi, Shengyong Cai, Renqing Zhu, Liang Chen
Iron overload has been regarded as a common cause for refractory epilepsies in patients after hemorrhagic strokes. This study is to examine the potential epilepsy control effect of deferoxamine (DFO), an iron chelator, on a ferric chloride-induced epilepsy rat model. Twenty four rats were divided into 4 groups: group I is blank control group, group II is sham group with intracortical injection of saline, group III is epilepsy group with intracortical injection of iron and saline treatment, group IV is treatment group with intracortical injection of iron and DFO treatment...
January 4, 2017: Brain Research
https://www.readbyqxmd.com/read/28063294/the-effect-of-coagulants-and-antiscalants-discharged-with-seawater-desalination-brines-on-coastal-microbial-communities-a-laboratory-and-in-situ-study-from-the-southeastern-mediterranean
#12
Natalia Belkin, Eyal Rahav, Hila Elifantz, Nurit Kress, Ilana Berman-Frank
Desalination outflows frequently discharge brine containing coagulants and antiscalants (e.g. Iron-hydroxides and polyphosphonates) to the coastal environment. Here we examined changes in composition and productivity of natural microbial coastal communities in experimental mesocosms treated with either iron-hydroxide (Fe), polyphosphonate (Pn), or a combination of high salinities with both chemicals (All). Within 2 h of addition Fe already altered the microbial community composition, enhanced the bacterial production (BP) and cell specific production (BP/BA), and decreased primary production...
December 10, 2016: Water Research
https://www.readbyqxmd.com/read/28062667/smn-deficiency-negatively-impacts-red-pulp-macrophages-and-spleen-development-in-mouse-models-of-spinal-muscular-atrophy
#13
Marie-Therese Khairallah, Jacob Astroski, Sarah K Custer, Elliot J Androphy, Craig L Franklin, Christian L Lorson
Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease that is the leading genetic cause of infantile death. It is caused by severe deficiency of the ubiquitously expressed Survival Motor Neuron (SMN) protein. SMA is characterized by α-lower motor neuron loss and muscle atrophy, however, there is a growing list of tissues impacted by SMN deficiency beyond motor neurons. The non-neuronal defects are observed in the most severe Type I SMA patients and most of the widely used SMA mouse models, however, as effective therapeutics are developed, it is unclear whether additional symptoms will be uncovered in longer lived patients...
January 5, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28061935/adsorption-of-vanadium-v-from-scr-catalyst-leaching-solution-and-application-in-methyl-orange
#14
Xuelong Sha, Wei Ma, Fanqing Meng, Ren Wang, Tian Fuping, Linsen Wei
  In this study, we explored an effective and low-cost catalyst and its adsorption capacity and catalytic capacity for Methyl Orange Fenton oxidation degradation were investigated. The catalyst was directly prepared by reuse of magnetic iron oxide (Fe3O4) after saturated adsorption of vanadium (V) from waste SCR (Selective Catalytic Reduction) catalyst. The obtained catalyst was characterized by FTIR, XPS and the results showed that vanadium (V) adsorption process of Fe3O4 nanoparticles was non-redox reaction...
December 1, 2016: Water Environment Research: a Research Publication of the Water Environment Federation
https://www.readbyqxmd.com/read/28061387/the-role-of-zero-valent-iron-on-the-fate-of-tetracycline-resistance-genes-and-class-1-integrons-during-thermophilic-anaerobic-co-digestion-of-waste-sludge-and-kitchen-waste
#15
Pin Gao, Chaochao Gu, Xin Wei, Xiang Li, Hong Chen, Hanzhong Jia, Zhenhong Liu, Gang Xue, Chunyan Ma
Activated sludge has been identified as a potential significant source of antibiotic resistance genes (ARGs) to the environment. Anaerobic digestion is extensively used for sludge stabilization and resource recovery, and represents a crucial process for controlling the dissemination of ARGs prior to land application of digested sludge. The objective of this study is to investigate the effect of zero valent iron (Fe(0)) on the attenuation of seven representative tetracycline resistance genes (tet, tet(A), tet(C), tet(G), tet(M), tet(O), tet(W), and tet(X)), and the integrase gene intI1 during thermophilic anaerobic co-digestion of waste sludge and kitchen waste...
December 27, 2016: Water Research
https://www.readbyqxmd.com/read/28061341/enhanced-reactivity-of-microscale-fe-cu-bimetallic-particles-mfe-cu-with-persulfate-ps-for-p-nitrophenol-pnp-removal-in-aqueous-solution
#16
Qingqing Ji, Jun Li, Zhaokun Xiong, Bo Lai
In this study, batch experiments were conducted to examine the enhanced reactivity of microscale Fe/Cu bimetallic particles (mFe/Cu) with persulfate (PS) for p-nitrophenol (PNP) removal in aqueous solution. The key operating parameters (i.e., theoretical Cu mass loadings (TMLCu), mFe/Cu dosage, PS dose, initial pH and temperature) were optimized by the batch experiments, respectively. The experimental data were followed well the pseudo-first-order kinetic model. Result reveals that refractory PNP (500 mg L(-1)) was effectively degraded by mFe/Cu-PS system with removal of 98...
December 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/28059036/reduction-of-doxorubicin-induced-cardiotoxicity-using-nanocarriers-a-review
#17
Michaela Fojtu, Jaromir Gumulec, Tibor Stracina, Martina Raudenska, Anna Skotakova, Marketa Vaculovicova, Vojtech Adam, Petr Babula, Marie Novakova, Michal Masarik
BACKGROUND: Anthracycline antibiotic doxorubicin (DOX) is a very potent and extensively prescribed chemotherapeutic drug. It is widely utilized in the therapy of variety of haematological and solid tumours, although its administration is commonly accompanied with several severe side effects. The most serious one is a development of dose-dependent and cumulative cardiotoxicity. In the course of time, many strategies have been investigated in order to avoid or at least to diminish DOX-induced cardiac dysfunction; these include reduction of toxic effect by co-administration with iron chelators (dexrazoxane), trastuzumab, taxanes, statins, and ACE-inhibitors...
January 5, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28055968/bh3-mimetics-suppress-cxcl12-expression-in-human-malignant-peripheral-nerve-sheath-tumor-cells
#18
Christopher D Graham, Niroop Kaza, Hawley C Pruitt, Lauren M Gibson, Barbara J Klocke, Lalita A Shevde, Steven L Carroll, Kevin A Roth
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, Schwann cell-derived neoplasms of the peripheral nervous system that have recently been shown to possess an autocrine CXCL12/CXCR4 signaling loop that promotes tumor cell proliferation and survival. Importantly, the CXCL12/CXCR4 signaling axis is driven by availability of the CXCL12 ligand rather than CXCR4 receptor levels alone. Therefore, pharmacological reduction of CXCL12 expression could be a potential chemotherapeutic target for patients with MPNSTs or other pathologies wherein the CXCL12/CXCR4 signaling axis is active...
December 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/28054605/catalyst-support-effects-on-hydrogen-spillover
#19
Waiz Karim, Clelia Spreafico, Armin Kleibert, Jens Gobrecht, Joost VandeVondele, Yasin Ekinci, Jeroen A van Bokhoven
Hydrogen spillover is the surface migration of activated hydrogen atoms from a metal catalyst particle, on which they are generated, onto the catalyst support. The phenomenon has been much studied and its occurrence on reducible supports such as titanium oxide is established, yet questions remain about whether hydrogen spillover can take place on nonreducible supports such as aluminium oxide. Here we use the enhanced precision of top-down nanofabrication to prepare controlled and precisely tunable model systems that allow us to quantify the efficiency and spatial extent of hydrogen spillover on both reducible and nonreducible supports...
January 4, 2017: Nature
https://www.readbyqxmd.com/read/28053961/iron-supplementation-reverses-the-reduction-of-hydroxymethylcytosine-in-hepatic-dna-associated-with-chronic-alcohol-consumption-in-rats
#20
Stephanie A Tammen, Jung Eun Park, Phil Kyung Shin, Simonetta Friso, Jayong Chung, Sang-Woon Choi
BACKGROUND: Alcohol is known to affect two epigenetic phenomena, DNA methylation and DNA hydroxymethylation, and iron is a cofactor of ten-eleven translocation (TET) enzymes that catalyze the conversion from methylcytosine to hydroxymethylcytosine. In the present study we aimed to determine the effects of alcohol on DNA hydroxymethylation and further effects of iron on alcohol associated epigenetic changes. METHODS: Twenty-four male Sprague-Dawley rats were fed either Lieber-DeCarli alcohol diet (36% calories from ethanol) or Lieber-DeCarli control diet along with or without iron supplementation (0...
December 2016: Journal of Cancer Prevention
keyword
keyword
105935
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"