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https://www.readbyqxmd.com/read/29041889/-multifactorial-prognostication-of-remote-outcomes-in-patients-with-non-st-elevation-acute-coronary-syndrome
#1
V O Tsygankova, G N Lozhkina, H M Khasanova, D A Kuimov, I Y Ragino, N V Maksimov, I M Voevoda
AIM: Creation of a mathematical nonlinear regression model for prognostication of 1 year outcomes after non-ST elevation acute coronary syndrome (NSTE ACS) for optimization of rehabilitation, secondary prevention, and personalized approach to treatment. MATERIAL AND METHODS: We included in this study 135 patients with confirmed NSTE ACS (mean age 59.1±6.1 years, 94 men and 41 women) admitted to hospital No 1 in Novosibirsk during 2010. During hospitalization and 1 year after discharge these patients received standard medical therapy...
August 2017: Kardiologiia
https://www.readbyqxmd.com/read/29033508/predictors-of-mortality-in-elderly-patients-with-non-st-elevation-acute-coronary-syndrome-data-from-taiwan-acute-coronary-syndrome-full-spectrum-registry
#2
Cheng-Chun Wei, Shih-Huang Lee
BACKGROUND: Some difficulties and variations remain associated with the care of elderly patients with non-ST elevation acute coronary syndrome (NSTE-ACS). METHODS: We included 1470 patients from a Taiwan nationwide registry who fulfilled the criteria of NSTE-ACS, and stratified these patients by age and evaluated the treatment, complications and outcomes in different age groups. Furthermore, we analyzed risk factors and standards of care to determine the predictors of mortality...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29033503/the-management-and-prognostic-factors-of-acute-coronary-syndrome-evidence-from-the-taiwan-acute-coronary-syndrome-full-spectrum-registry
#3
REVIEW
Chun-Yuan Chu, Tsung-Hsien Lin, Wen-Ter Lai
Cardiovascular disease (CVD) accounts for approximately one-third of all global deaths, and acute coronary syndrome (ACS) is the most severe form of CVD. It is of notable importance to develop ACS strategies for reducing major adverse cardiac events (MACE) and preventing complications. In the Taiwan ACS Full Spectrum Registry, 1-year mortality among patients with ST-segment elevation myocardial infarction, non ST-segment elevation myocardial infarction and unstable angina was 6.1%, 10.1%, and 6.2%, respectively...
July 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29023996/effect-of-sex-difference-in-clinical-presentation-stable-coronary-artery-disease-vs-unstable-angina-pectoris-or-non-st-elevation-myocardial-infarction-vs-st-elevation-myocardial-infarction-on-2-year-outcomes-in-patients-undergoing-percutaneous-coronary-intervention
#4
Xiao-Fang Tang, Ying Song, Jing-Jing Xu, Yuan-Liang Ma, Jia-Hui Zhang, Yi Yao, Chen He, Huan-Huan Wang, Ping Jiang, Lin Jiang, Ru Liu, Zhan Gao, Xue-Yan Zhao, Shu-Bin Qiao, Bo Xu, Yue-Jin Yang, Run-Lin Gao, Jin-Qing Yuan
OBJECTIVE: To determine whether there is a difference in 2-year prognosis among patients across the spectrum of coronary artery disease undergoing percutaneous coronary intervention (PCI). METHODS: We analyzed all consecutive patients undergoing PCI at a single center from 1/1-12/31/2013. Clinical presentations were compared between sexes according to baseline clinical, angiographic, and procedural characteristics and 2-year (mean 730 ± 30-day) outcomes. RESULTS: We grouped 10 724 consecutive patients based on sex and clinical presentation...
October 11, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28993178/a-user-friendly-risk-score-for-predicting-in-hospital-cardiac-arrest-among-patients-admitted-with-suspected-non-st-elevation-acute-coronary-syndrome-the-safer-score
#5
Jonas Faxén, Marlous Hall, Chris P Gale, Johan Sundström, Bertil Lindahl, Tomas Jernberg, Karolina Szummer
AIM: To develop a simple risk-score model for predicting in-hospital cardiac arrest (CA) among patients hospitalized with suspected non-ST elevation acute coronary syndrome (NSTE-ACS). METHODS: Using the Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART), we identified patients (n=242 303) admitted with suspected NSTE-ACS between 2008 and 2014. Logistic regression was used to assess the association between 26 candidate variables and in-hospital CA...
October 6, 2017: Resuscitation
https://www.readbyqxmd.com/read/28980282/long-term-outcomes-of-patients-with-multivessel-coronary-artery-disease-presenting-non-st-segment-elevation-acute-coronary-syndromes
#6
Piotr Desperak, Michał Hawranek, Paweł Gąsior, Aneta Desperak, Andrzej Lekston, Mariusz Gąsior
BACKGROUND: There is paucity of data concerning the optimal revascularization in patients with multivessel coronary artery disease (CAD) presenting non-ST-segment elevation acute coronary syndrome (NSTE-ACS). The aim was to evaluate long-term outcomes of patients with multivessel CAD presenting NSTE-ACS depending on the management after coronary angiography. METHODS: 3,166 patients with NSTE-ACS hospitalized between 2006-2014 were screened. After exclusions, 1,342 patients were enrolled with multivessel CAD and were divided depending on their management after coronary angiography; the medical-only therapy group (n = 91), the PCI group (n = 1,122), the CABG group (n = 129)...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28966444/percutaneous-coronary-intervention-and-inpatient-mortality-in-patients-with-advanced-chronic-kidney-disease-presenting-with-acute-coronary-syndrome
#7
Brijesh Patel, Mahek Shah, Raman Dusaj, Sharon Maynard, Nainesh Patel
Chronic kidney disease (CKD) is an important risk factor for coronary artery disease, yet patients with CKD are less likely to undergo coronary angiography and percutaneous coronary intervention (PCI). We retrospectively analyzed the 2006-2012 National Inpatient Sample Database to examine the temporal trends in coronary angiography and PCI among patients without CKD, with advanced CKD (CKD III-V), and with end-stage renal disease (ESRD) presenting with unstable angina/non-ST elevation myocardial infarction (NSTE-ACS) and ST-elevation myocardial infarction (STEMI)...
October 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28921624/pharmacodynamics-and-pharmacokinetics-of-ticagrelor-versus-clopidogrel-in-patients-with-acute-coronary-syndromes-and-chronic-kidney-disease
#8
Heyang Wang, Jing Qi, Yi Li, Yunbiao Tang, Chao Li, Jing Li, Yaling Han
BACKGROUND: Pivotal clinical trials found ticagrelor reduced ischemic complications to a greater extent than clopidogrel and what is more, the benefit gradually increased with the reduction on creatinine clearance. However, the underlying mechanisms remains poorly explored. METHODS: This is a single-center, prospective, randomized clinical trial involving 60 hospitalized P2Y12 inhibitor naïve patients with CKD (eGFR<60ml/min/1.73m(2) ) and NSTE-ACS. Eligible patients were randomly assigned in a 1:1 ratio to receive ticagrelor(180 mg loading dose, then 90 mg twice daily followed) or clopidogrel(600 mg loading dose, then 75 mg qd followed)...
September 15, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28874297/patients-with-non-st-segment-elevation-acute-coronary-syndromes-managed-without-coronary-revascularization-a-population-needing-treatment-improvement
#9
Alberto Menozzi, Stefano De Servi, Roberta Rossini, Marco Ferlini, Daniela Lina, Maurizio Giuseppe Abrignani, Piera Capranzano, Nazario Carrabba, Marcello Galvani, Alfredo Marchese, Gianfranco Mazzotta, Luciano Moretti, Nicola Signore, Massimo Uguccioni, Zoran Olivari, Leonardo De Luca
NSTE-ACS patients are a heterogeneous population, with different clinical features and prognosis. A large proportion of them is medically managed, without any revascularization. In the EYSHOT and FAST-MI registries such patients were 40% and 35%, respectively. These patients are at higher risk of adverse cardiovascular events and have a worse prognosis compared with those receiving revascularization. Medically managed NSTE-ACS patients consist of different subgroups: those not undergoing coronary angiography, those without significant coronary artery disease, and those with coronary stenoses not referred to revascularization...
October 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28840515/high-sensitivity-cardiac-troponin-for-the-diagnosis-of-patients-with-acute-coronary-syndromes
#10
REVIEW
Vlad C Vasile, Allan S Jaffe
PURPOSE OF REVIEW: High-sensitivity cardiac troponin (hscTn) assays are replacing the older-generation assays used to detect myocardial injury because they have improved analytical sensitivity and lead to a more rapid diagnosis of acute myocardial infarction (AMI) and enhanced risk stratification in patients with non-ST elevation acute coronary syndromes (NSTE-ACS). This review focuses on advantages and difficulties of using hscTn as diagnostic and prognostic tools in acute coronary syndromes (ACS)...
August 24, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28838475/comparison-of-ticagrelor-versus-prasugrel-for-inflammation-vascular-function-and-circulating-endothelial-progenitor-cells-in-diabetic-patients-with-non-st-segment-elevation-acute-coronary-syndrome-requiring-coronary-stenting-a-prospective-randomized-crossover
#11
Han Saem Jeong, Soon Jun Hong, Sang-A Cho, Jong-Ho Kim, Jae Young Cho, Seung Hun Lee, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
OBJECTIVES: This study compared adenosine-associated pleiotropic effects of the 2 P2Y12 receptor antagonists on vascular function, systemic inflammation, and circulating endothelial progenitor cells (EPCs). BACKGROUND: Both ticagrelor and prasugrel have potent antiplatelet effects. However, only ticagrelor inhibits cellular uptake of adenosine. METHODS: Using a randomized, crossover design with 10-week follow-up ticagrelor or prasugrel was administered to type 2 diabetic patients with non-ST-segment elevation acute coronary syndrome requiring stent implantation...
August 28, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28830367/mir-941-as-a-promising-biomarker-for-acute-coronary-syndrome
#12
Ruina Bai, Qiaoning Yang, Ruixi Xi, Lizhi Li, Dazhuo Shi, Keji Chen
BACKGROUND: Circulating miRNAs can function as biomarkers for diagnosis, treatment, and prevention of diseases. However, it is unclear whether miRNAs can be used as biomarkers for acute coronary syndrome (ACS). To this end, we applied gene chip technology to analyze miRNA expression in patients with stable angina (SA), non-ST elevation ACS (NSTE-ACS), and ST-segment elevation myocardial infarction (STEMI). METHODS: We enrolled patients with chest pain who underwent diagnostic coronary angiography, including five patients each with SA, NSTE-ACS, or STEMI, and five controls without coronary artery disease (CAD) but with three or more risk factors...
August 22, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28822510/high-versus-low-dose-statin-therapy-in-indian-patients-with-acute-st-segment-elevation-myocardial-infarction-undergoing-thrombolysis
#13
K Priti, Anand Agrawal, Bhanwar L Ranwa
OBJECTIVES: This study sought to compare high dose versus low dose statin therapy in Indian patients with ST-segment elevation myocardial infarction (STEMI) undergoing thrombolysis. BACKGROUND: Randomized trials have demonstrated that statin treatment reduced major adverse cardiac events (MACEs) in patients with stable angina pectoris and acute coronary syndrome. However, randomized studies of statin therapy in Indian patients with STEMI are scarce. METHODS: Of 1859 patients with acute STEMI, 1027 eligible patients were randomized to 80-mg (n=512) or 10-mg (n=515) atorvastatin...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28818351/recent-trends-in-management-and-outcome-of-patients-with-acute-coronary-syndromes-and-atrial-fibrillation
#14
Leonardo De Luca, Gianni Casella, Andrea Rubboli, Lucio Gonzini, Donata Lucci, Alessandro Boccanelli, Francesco Chiarella, Antonio Di Chiara, Stefano De Servi, Andrea Di Lenarda, Giuseppe Di Pasquale, Stefano Savonitto
AIMS: To describe the clinical characteristics, contemporary trends of in-hospital management and outcome of patients admitted for an acute coronary syndrome (ACS) with associated atrial fibrillation (AF). METHODS: We analyzed data from four Italian nationwide prospective registries, conducted between 2001 and 2014, including consecutive ACS patients. RESULTS: Out of 16,803 ACS patients, 1019 (6.1%) presented with concomitant AF: 668 with non-ST elevation (NSTE)-ACS and 351 with ST-elevation myocardial infarction (STEMI)...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28802810/early-invasive-versus-initially-conservative-strategy-in-elderly-patients-older-than-75-years-with-non-st-elevation-acute-coronary-syndrome-a-meta-analysis
#15
Wenfang Ma, Yan Liang, Jun Zhu
BACKGROUND: Fear of complications related to the procedure and unclear benefits in elderly patients are common reasons for invasive angiography being withheld. METHODS: We searched PubMed and Embase from inception until February 2016 for studies that enrolled individuals older than 75 years with non-ST-elevation acute coronary syndrome (NSTE-ACS) and allocated patients to either an invasive or conservative strategy. RESULTS: Thirteen studies (four randomised controlled trials (RCTs) and nine observational studies) enrolling 832,007 elderly NSTE-ACS patients were analysed...
July 17, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28764841/non-st-elevation-acute-coronary-syndromes-a-comprehensive-review
#16
Tamunoinemi Bob-Manuel, Ikechuckwu Ifedili, Guy Reed, Uzoma N Ibebuogu, Rami N Khouzam
Non-ST elevation-acute coronary syndrome (NSTE-ACS) includes NSTE myocardial infarction and unstable angina. This patient population forms approximately two-thirds of all hospital admissions for ACS in the United States each year and is associated with an in-hospital mortality of 5%. NSTE-ACS is primarily due to an acute change in the supply and demand balance of coronary perfusion and myocardial oxygen consumption, because of the significant coronary artery obstruction presenting as plaque rupture or erosion...
September 2017: Current Problems in Cardiology
https://www.readbyqxmd.com/read/28747021/characteristics-and-outcomes-of-medically-managed-patients-with-non-st-segment-elevation-acute-coronary-syndromes-insights-from-the-multinational-epicor-asia-study
#17
Chee Tang Chin, Tiong K Ong, Rungroj Krittayaphong, Stephen W-L Lee, Jitendra P S Sawhney, Hyo-Soo Kim, Angeles Alonso Garcia, Héctor Bueno, Stuart J Pocock, Vo T Nhan, Ana Vega, Nobuya Hayashi, Yong Huo
BACKGROUND: Many patients with non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are medically managed without coronary revascularization. The reasons vary and may impact prognosis. METHODS: EPICOR Asia (NCT01361386) is a prospective study of hospital survivors post-ACS enrolled in 218 hospitals from 8 countries/regions in Asia (06/2011-05/2012). All medically managed NSTE-ACS patients were classified into 3 groups: 1) no coronary angiography (CAG-); 2) non-significant coronary artery disease (CAD) on angiogram (CAG+ CAD-); and 3) significant CAD (CAG+ CAD+)...
September 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28715070/evaluation-of-the-relationship-between-renal-resistive-index-and-extensivity-and-complexity-of-coronary-artery-disease-in-patients-with-acute-coronary-syndrome
#18
Alaa Quisi, Ibrahim Halil Kurt, Durmuş Yıldıray Şahin, Onur Kaypaklı, Gökhan Söker, Ömer Kaya, Samir Allahverdiyev, Ömer Genç, Gökhan Alıcı, Mevlüt Koç
BACKGROUND: Despite the advances in cardiovascular medicine, acute coronary syndrome (ACS) is still a major cause of morbidity and mortality worldwide. Synergy between PCI ™ with TAXUS and Cardiac Surgery (SYNTAX) score is used to determine the extensivity and complexity of coronary artery disease (CAD). Renal resistive index (RRI), a renal Doppler ultrasound parameter, is used to detect renal hemodynamics. Although some risk factors for CAD, including hypertension and diabetes mellitus were demonstrated to have an association with RRI, direct relationship between the presence...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28647999/-relationship-between-the-ratio-of-neutrophil-lymphocyte-and-risk-stratification-prognosis-in-patients-with-non-st-elevation-acute-coronary-syndrome
#19
Y Wang, S J Jia, Z Chi
Objective: To investigate the value of neutrophil to lymphocyte ratio (NLR) in predicting risk stratification and prognosis in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Methods: A total of 227 NSTE-ACS patients after percutaneous coronary intervention (PCI) were collected from September 2012 to September 2014 in Beijing Anzhen Hospital.Groups: (1)According to NLR, the patients were divided into 3 groups: NLR<2.20 group; 2.2≤NLR<3.33 group; NLR≥3.33 group.(2)According to the global registry of acute coronary events (GRACE) score, the patients were divided into 3 groups: Low-risk group, Medium-risk group and High-risk group...
June 20, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28647406/unstable-angina-in-the-era-of-cardiac-troponin-assays-with-improved-sensitivity-a-clinical-dilemma
#20
K M Eggers, T Jernberg, B Lindahl
INTRODUCTION: There is an expectation that with the adoption of more sensitive cardiac troponin (cTn) assays, unstable angina would become a rarity. However, recent data from the SWEDEHEART registry demonstrated that 15% of patients admitted with non ST-elevation acute coronary syndrome (NSTE-ACS) still were regarded having unstable angina. We aimed to further investigate the clinical characteristics and outcome of these patients. METHODS: Retrospective registry-based analysis (SWEDEHEART) including 3204 unstable patients, 18,194 non ST-elevation myocardial infarction (NSTEMI) patients and 977 controls without acute cardiovascular disease...
June 21, 2017: American Journal of Medicine
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