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muscle invasive urothelial bladder cancer

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https://www.readbyqxmd.com/read/28940228/asthma-status-is-associated-with-decreased-risk-of-aggressive-urothelial-bladder-cancer
#1
Marta Rava, Maciej J Czachorowski, Debra Silverman, Mirari Márquez, Sirish Kishore, Adonina Tardón, Consol Serra, Montse García-Closas, Reina Garcia-Closas, Alfredo Carrato, Nathaniel Rothman, Francisco X Real, Manolis Kogevinas, Núria Malats
Previous studies suggested an association between atopic conditions and specific cancers. The results on the association with urothelial bladder cancer (UBC) are scarce and inconsistent. To evaluate the association between asthma and risk of UBC, we considered 936 cases and 1022 controls from the Spanish Bladder Cancer/EPICURO Study (86% males, mean age 65.4 years), a multicenter and hospital based case-control study conducted during 1998-2001. Participants were asked whether they had asthma and detailed information about occupational exposures, smoking habits, dietary factors, medical conditions, and history of medication was collected through face-to-face questionnaires performed by trained interviewers...
September 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28938555/exosomes-of-invasive-urothelial-carcinoma-cells-are-characterized-by-a-specific-mirna-expression-signature
#2
Sophie Baumgart, Sebastian Hölters, Carsten-Henning Ohlmann, Rainer Bohle, Michael Stöckle, Marie Stampe Ostenfeld, Lars Dyrskjøt, Kerstin Junker, Joana Heinzelmann
Muscle-invasive bladder cancer (MIBC) represents a highly aggressive tumor type compared to non-muscle-invasive tumors. MIBC is characterized by specific molecular alterations, which may also modulate extracellular tumorigenic effects. Tumor-associated exosomes, especially exosomal miRNAs, are important regulators in the interaction between tumor cells and tumor microenvironment by affecting tumor-promoting processes in target cells. It is important to analyze whether their exosomal patterns also reflect the specific molecular characteristics of MIBC...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28936147/lymph-node-density-in-muscle-invasive-transitional-cell-carcinoma-of-the-urinary-bladder-de-novo-versus-progressive-disease
#3
Ahmed Elabbady, Mohamed Mohieeldin Hashad, Ahmed Fouad Kotb, Dina Mohamed Abdullah, Ahmad Beltagy
OBJECTIVE: The prognosis of bladder cancer patients with positive lymph node (LN) disease is affected by both the extent of lymphadenectomy and LN density retrieved during radical cystectomy. This study aimed at assessing the differences in LN metastasis between patients who presented primarily with muscle-invasive transitional cell carcinoma of the bladder "de novo disease" versus "progressive disease." The latter is defined as patients who progressed to muscle-invasive bladder cancer (MIBC) following prior conservative management of a non-muscle-invasive disease...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28928159/bmp4-induces-m2-macrophage-polarization-and-favors-tumor-progression-in-bladder-cancer
#4
Víctor G Martínez, Carolina Rubio, Mónica Martínez-Fernández, Cristina Segovia, Fernando López-Calderón, Marina Garín, Alicia Teijeira, Ester Munera-Maravilla, Alberto Varas, Rosa Sacedón, Felix Guerrero-Ramos, Felipe Villacampa, Federico de la Rosa, Daniel Castellano, Eduardo López-Collazo, Jesus M Paramio, Ángeles Vicente, Marta Dueñas
PURPOSE: Bladder cancer (BC) is a current clinical and social problem. At diagnosis, most patients present non-muscle invasive tumors, characterized by a high recurrence rate, which could progress to muscle invasive disease and metastasis. Bone morphogenetic protein (BMP)-dependent signaling arising from stromal bladder tissue mediates urothelial homeostasis by promoting urothelial cell differentiation. However, the possible role of BMP ligands in BC is still unclear. EXPERIMENTAL DESIGN: Tumor and normal tissue from 68 patients with urothelial cancer were prospectively collected and analyzed for expression of BMP and macrophage markers...
September 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28923700/venous-thromboembolism-risk-in-patients-with-locoregional-urothelial-tract-tumors
#5
Jorge D Ramos, Jonathan T Wingate, Roman Gulati, Elizabeth R Plimack, Lauren C Harshman, Thomas Powles, Simon J Crabb, Guenter Niegisch, Joaquim Bellmunt, Sylvain Ladoire, Ugo De Giorgi, Syed Hussain, Ajjai S Alva, Jack Baniel, Neeraj Agarwal, Jonathan E Rosenberg, Ulka N Vaishampayan, Matthew D Galsky, Evan Y Yu
BACKGROUND: Venous thromboembolism (VTE) is common in cancer patients, but there is limited data on patients with urothelial tract tumors (UTT). We previously identified several associative factors for increased VTE rates in patients with metastatic UTT. In this study, we assessed the frequency, associative factors, and impact on survival of VTE in patients with locoregional UTT. METHODS: Patients with locoregional bladder, upper urinary tract, or urethral cancer were included in this multi-center study from 29 academic institutions...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28920525/can-urologists-accurately-stage-and-grade-urothelial-bladder-cancer-by-assessing-endoscopic-photographs
#6
Snir Dekalo, Haim Matzkin, Nicola J Mabjeesh
Introduction Assessment of urothelial bladder cancer during cystoscopy or transurethral resection of bladder tumour has a significant impact on the urologist's decision-making: treatment with simple outpatient fulguration, required depth of resection, and need of immediate post-surgical intravesical therapy. These choices depend heavily on the urologist's ability to accurately assess pre-biopsy tumour stage and grade. The aim of the study was to determine whether evaluation of photographs taken during transurethral resection of bladder tumour can reliably characterize a tumour's stage and grade...
January 1, 2017: Journal of Telemedicine and Telecare
https://www.readbyqxmd.com/read/28916862/monitoring-the-response-of-urothelial-precancerous-lesions-to-bacillus-calmette-guerin-at-the-proteome-level-in-an-in-vivo-rat-model
#7
Kerem Teke, Nil Guzel, Ali Kemal Uslubas, Murat Kasap, Hasan Yilmaz, Gurler Akpinar, Demir Kursat Yildiz, Ozdal Dillioglugil
Intravesical Bacillus Calmette-Guerin (BCG) is the best treatment modality for progression of non-muscle invasive bladder cancer. We aimed to monitor changes at the proteome level to identify putative protein biomarkers associated with the response of urothelial precancerous lesions to intravesical BCG treatment. The rats were divided into three groups (n = 10/group): control, non-treated, and BCG-treated groups. The non-treated and BCG-treated groups received N-methyl-N-nitrosourea intravesically. BCG Tice-strain was instilled into bladder in BCG-treated group...
September 15, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28902383/-bcgitis-with-involvement-of-lung-liver-and-bone-marrow%C3%A2-after-immunotherapy-of-urothelial-cancer
#8
Hilte Friederike Geerdes-Fenge, Franziska Stubbe, Micha Löbermann, Philipp Warnke, Andreas Erbersdobler, Emil Christian Reisinger
Medical history A 77-year-old patient with transurethral resection of a bladder tumor was transferred due to persistent fever and progressive dyspnea despite antibiotic therapy for suspected urinary tract infection. Repeating the medical history revealed that a BCG immunotherapy of his non-muscle-invasive bladder carcinoma was performed the day before fever developed. Therefore, BCGitis was suspected. Examinations Laboratory parameters showed pancytopenia, elevated liver enzymes, eleveated C-reactive protein and hypoxemia...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28899722/effect-of-nonurothelial-histologic-variants-on-the-outcomes-of-radical-cystectomy-for-nonmetastatic-muscle-invasive-urinary-bladder-cancer
#9
Malte W Vetterlein, Thomas Seisen, Jeffrey J Leow, Mark A Preston, Maxine Sun, David F Friedlander, Christian P Meyer, Felix K-H Chun, Stuart R Lipsitz, Mani Menon, Adam S Kibel, Joaquim Bellmunt, Toni K Choueiri, Quoc-Dien Trinh
INTRODUCTION: Knowledge of the comparative oncologic outcomes of histologic variants after radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC) relies on small case series. We compared the effect of pure squamous cell carcinoma, adenocarcinoma, and neuroendocrine carcinoma compared with pure urothelial carcinoma (PUC) on overall survival (OS) and pathologic tumor, lymph node, and surgical margin status after RC. PATIENTS AND METHODS: Using the National Cancer Database, we retrospectively examined patients undergoing RC for MIBC from 2003 to 2011...
August 24, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28898400/intravesical-electromotive-drug-administration-for-non-muscle-invasive-bladder-cancer
#10
REVIEW
Jae Hung Jung, Ahmet Gudeloglu, Halil Kiziloz, Gretchen M Kuntz, Alea Miller, Badrinath R Konety, Philipp Dahm
BACKGROUND: Electromotive drug administration (EMDA) is the use of electrical current to improve the delivery of intravesical agents to reduce the risk of recurrence in people with non-muscle invasive bladder cancer (NMIBC). It is unclear how effective this is in comparison to other forms of intravesical therapy. OBJECTIVES: To assess the effects of intravesical EMDA for the treatment of NMIBC. SEARCH METHODS: We performed a comprehensive search using multiple databases (CENTRAL, MEDLINE, EMBASE), two clinical trial registries and a grey literature repository...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28889382/urothelial-carcinoma-stem-cells-current-concepts-controversies-and-methods
#11
Jiri Hatina, Hamendra Singh Parmar, Michaela Kripnerova, Anastasia Hepburn, Rakesh Heer
Cancer stem cells are defined as a self-renewing and self-protecting subpopulation of cancer cells able to differentiate into morphologically and functionally diverse cancer cells with a limited lifespan. To purify cancer stem cells, two basic approaches can be applied, the marker-based approach employing various more of less-specific cell surface marker molecules and a marker-free approach largely based on various self-protection mechanisms. Within the context of urothelial carcinoma, both methods could find use...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28889377/molecular-subtype-profiling-of-urothelial-carcinoma-using-a-subtype-specific-immunohistochemistry-panel
#12
Gottfrid Sjödahl
Molecular subtypes of bladder cancer (BC) can be determined by relatively small immunohistochemistry panels both for non-muscle invasive (NMI) and muscle invasive (MI) tumors. For analysis of NMI tumors, as few as two markers are needed, although classification is dependent also on pathological grade and histological evaluation. The result is a classification into the three tumor-cell phenotypes of NMI-BC, Urothelial-like (Uro), Genomically Unstable (GU), and Basal/SCC-like. For analysis of MI tumors, 13 markers are needed...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28888813/gender-specific-differences-in-recurrence-of-non-muscle-invasive-bladder-cancer-a-systematic-review-and-meta-analysis
#13
REVIEW
Annemarie Uhlig, Arne Strauss, Ali Seif Amir Hosseini, Joachim Lotz, Lutz Trojan, Marianne Schmid, Johannes Uhlig
CONTEXT: The incidence of urothelial carcinoma of the bladder (UCB) is lower in women; however, women tend to present with more advanced disease. To date, there is no quantitative synthesis of studies reporting gender-specific outcomes in non-muscle-invasive UCB. OBJECTIVE: To conduct a meta-analysis evaluating gender-specific differences in recurrence of non-muscle-invasive urinary bladder cancer (NMIBC). EVIDENCE ACQUISITION: An unrestricted systematic literature search of the MEDLINE, EMBASE, and Cochrane libraries was conducted...
September 6, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28881475/the-cancer-of-the-bladder-risk-assessment-cobra-score-estimating-mortality-after-radical-cystectomy
#14
Christopher J Welty, Thomas H Sanford, Jonathan L Wright, Peter R Carroll, Matthew R Cooperberg, Maxwell V Meng, Sima P Porten
BACKGROUND: Risk stratification of patients with urothelial carcinoma of the bladder (UCB) after cystectomy has important clinical and research implications. The authors assessed the relative effect of tumor stage and lymph node status on cancer-specific survival (CSS) after cystectomy and developed a simplified risk-assessment tool. METHODS: In total, 14,828 patients who underwent cystectomy with lymph node dissection for UCB were identified from the Surveillance, Epidemiology, and End Results database (1988-2011)...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28872778/effects-of-thiazolidinedione-in-patients-with-active-bladder-cancer
#15
Roger Li, Michael J Metcalfe, J E Ferguson Rd, Sharada Mokkapati, Graciela M Nogueras González, Colin P Dinney, Neema Navai, David J McConkey, Sunil K Sahai, Ashish M Kamat
OBJECTIVE: To examine the influence of perioperative thiazolidinedione (TZD) on cancer-specific outcomes in patients undergoing radical cystectomy (RC) for urothelial carcinoma (UC). DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort of 173 diabetic patients undergoing RC from 2005 to 2010 was identified. Of those, 53 were on TZD treatment at the time of surgery, with 33 patients taking pioglitazone. Baseline clincopathologic characteristics, as well as cancer specific survival (CSS), recurrence free survival (RFS), and overall survival (OS) were compared between the patients on and off of TZD at the time of RC...
September 5, 2017: BJU International
https://www.readbyqxmd.com/read/28864844/checkpoint-inhibitors-the-new-treatment-paradigm-for-urothelial-bladder-cancer
#16
REVIEW
Heather Katz, Emnet Wassie, Mohamed Alsharedi
Bladder cancer is the most common malignancy involving the genitourinary system (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). In the USA, it is the fifth most common cancer and approximately 79,000 new cases will be diagnosed in 2017 (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). The mortality from bladder cancer is approximately 17,000 deaths each year (Siegel et al. in CA Cancer J Clin, 66:7-30, 2016). The incidence rate for bladder cancer is higher in men compared to women. Risk factors are predominantly related to tobacco smoking, although infection with Schistosoma haematobium is another risk factor in selected populations (Antoni et al...
September 1, 2017: Medical Oncology
https://www.readbyqxmd.com/read/28853615/radical-cystectomy-or-bladder-preservation-with-radiochemotherapy-in-elderly-patients-with-muscle-invasive-bladder-cancer-retrospective-international-study-of-cancers-of-the-urothelial-tract-risc-investigators
#17
Jihane Boustani, Aurélie Bertaut, Matthew D Galsky, Jonathan E Rosenberg, Joaquim Bellmunt, Thomas Powles, Federica Recine, Lauren C Harshman, Simon Chowdhury, Guenter Niegisch, Evan Y Yu, Sumanta K Pal, Ugo De Giorgi, Simon J Crabb, Matthieu Caubet, Loïc Balssa, Matthew I Milowsky, Sylvain Ladoire, Gilles Créhange
BACKGROUND: Radical cystectomy (RC) and radiochemotherapy (RCT) are curative options for muscle-invasive bladder cancer (MIBC). Optimal treatment strategy remains unclear in elderly patients. MATERIAL AND METHODS: Patients aged 80 years old and above with T2-T4aN0-2M0-Mx MIBC were identified in the Retrospective International Study of Cancers of the Urothelial Tract (RISC) database. Patients treated with RC were compared with those treated with RCT. The impact of surgery on overall survival (OS) was assessed using a Cox proportional hazard model...
August 30, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28843746/cytological-and-histological-changes-in-the-urothelium-produced-by-electromotive-drug-administration-emda-and-by-the-combination-of-intravescical-hyperthermia-and-chemotherapy-thermochemotherapy
#18
Francesco Pierconti, Patrizia Straccia, Sacco Emilio, Pier Francesco Bassi, Ivana De Pascalis, Rita C Marques, Metka Volavsek, Luigi M Larocca, Antonio Lopez-Beltran
The treatment of non muscle-invasive bladder cancer (NMIBC) encompasses a range of different procedures. Electromotive drug administration (EMDA) and chemo-hyperthermia (C-HT; Synergo) represent a minimally-invasive methods of intravesical instillation of therapeutic agents as mitomycin C (MMC). We selected patients with high grade NMIBC, BCG non responder, treated with EMDA/MMC and C-HT/MMC and we also examined the morphological changes in urine cytology samples. During the period from 2012 to 2014, 110 patients with high grade NMIBC, BCG refractory were selected...
August 1, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28837258/diagnostic-and-prognostic-role-of-urinary-collagens-in-primary-human-bladder-cancer
#19
Makito Miyake, Yosuke Morizawa, Shunta Hori, Yoshihiro Tatsumi, Sayuri Onishi, Takuya Owari, Kota Iida, Kenta Onishi, Daisuke Goto, Yasushi Nakai, Satoshi Anai, Yoshitomo Chihara, Kazumasa Torimoto, Katsuya Aoki, Nobumichi Tanaka, Keiji Shimada, Noboru Konishi, Kiyohide Fujimoto
Collagen type 4 alpha 1 (COL4A1) and collagen type 13 alpha 1 (COL13A1) produced by urothelial cancer cells support the vital oncogenic property of tumor invasion. We investigated the diagnostic and prognostic capability of COL4A1 and COL13A1 in voided urine and compared the observed values with those of CYFRA21-1, NMP-22, and voided urine cytology in bladder cancer (BCa). We collected voided urine samples from 154 patients newly diagnosed with BCa, before surgery and from 61 control subjects. Protein levels of COL4A1, COL13A1, CYFRA21-1, and NMP-22 in urine supernatants were measured using enzyme-linked immunosorbent assays...
August 24, 2017: Cancer Science
https://www.readbyqxmd.com/read/28837252/cbx8-is-a-predictor-of-muscle-invasive-bladder-cancer-and-promotes-cell-proliferation-by-repressing-the-p53-pathway
#20
Gang-Jun Yuan, Xin Chen, Jun Lu, Zi-Hao Feng, Si-Liang Chen, Ri-Xin Chen, Wen-Su Wei, Fang-Jian Zhou, Dan Xie
CBX8, also known as human polycomb 3, is a repressor that maintains the transcriptionally repressive state in various cellular genes, and has been reported to promote tumorigenesis. In the present study we examined the CBX8 expression in 8 pairs of muscle invasive bladder cancer tissues and adjacent non-tumor tissues, and found that CBX8 was frequently upregulated in muscle invasive bladder cancer tissues when compared to adjacent non-tumor tissues. Analysis showed that high expression of CBX8 in 152 muscle invasive bladder cancer specimens was associated with progression of the T-, N-, and M stage (P = 0...
August 24, 2017: Cancer Science
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