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muscle invasive urothelial bladder cancer

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https://www.readbyqxmd.com/read/29776013/prognostic-pathologic-factors-in-radical-cystectomy-after-neoadjuvant-chemotherapy
#1
Fadi Brimo, Michelle R Downes, Tamara Jamaspishvili, David Berman, Guliz A Barkan, Daniel Athanazio, Schuharazad Abro, Kash Visram, Asli Yilmaz, Shraddha Solanki, Elan Hahn, Robert Siemens, Wassim Kassouf, Kiril Trpkov
We undertook a systematic evaluation of the prognostic value of numerous histologic factors in 165 radical cystectomies (RC) of patients with invasive urothelial carcinoma who underwent surgery after neoadjuvant chemotherapy (NAC). Tumor regression grade (TRG) and therapy-related stromal and epithelial changes were also recorded. Locally advanced disease (≥pT2 and/or pN+) was present in 64% of patients, 22% had no evidence of residual carcinoma (pT0+pN0) and 28% had no evidence of residual muscle invasive carcinoma (≤pT1+N0)...
May 18, 2018: Histopathology
https://www.readbyqxmd.com/read/29767328/a-placebo-controlled-efficacy-study-of-the-intravesical-immunomodulators-tmx-101-and-tmx-202-in-an-orthotopic-bladder-cancer-rat-model
#2
Johannes Falke, Christina A Hulsbergen-van de Kaa, Roberto Maj, Egbert Oosterwijk, J Alfred Witjes
PURPOSE: TMX-101 and TMX-202 are formulations of toll-like receptor 7 (TLR-7) agonists, under investigation for the treatment of urothelial carcinoma. Our goal was to evaluate the efficacy of intravesical instillations of TMX-101 or TMX-202 in an orthotopic bladder cancer rat model. METHODS: Four groups of 14 rats received an instillation with isogenic AY-27 tumor cells on day 0, starting tumor development. On day 2 and 5, the rats were treated with an intravesical instillation of TMX-101 0...
May 16, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29745927/-new-endovesical-chemotherapy-drugs-and-application-vehicles
#3
Emilio Rios González, Luis Martínez-Piñeiro
Urothelial bladder cancer is a very prevalent disease. At the time of diagnosis 70-80% of the cases present as non muscle invasive tumors. These tumors present a high recurrence and progression rates despite intravesical treatment with Bacille Calmette-Guerin and mitomycin C. Moreover, bladder conditions such as its wall impermeability and the fact that intravesical drugs are constantly being diluted by urine and eliminated do not favor the efficacy of intravesical treatment. This review analyzes new intravesical drugs such as gemcitabine or taxanes with promising results as alternative to the usual treatments or after their failure...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29744601/asymptomatic-recurrence-detection-and-cost-effectiveness-in-urothelial-carcinoma
#4
REVIEW
Hiromichi Iwamura, Shingo Hatakeyama, Makoto Sato, Chikara Ohyama
For the management of muscle-invasive bladder cancer or upper tract urothelial carcinoma, the set guidelines recommend regular surveillance after radical cystectomy or radical nephroureterectomy. However, the prognostic benefit of regular oncological surveillance remains controversial in the absence of prospective studies although several retrospective studies with relatively large sample sizes have demonstrated the association between asymptomatic recurrence and better oncological outcomes. Seven out of eight studies reported that patients diagnosed with symptomatic recurrence showed significantly poorer prognosis in comparison to those diagnosed with asymptomatic recurrence...
May 9, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29733795/muscle-invasive-bladder-and-urethral-cancer-recurrence-after-surgical-management-of-upper-tract-urothelial-carcinoma-a-review-of-305-patients
#5
Mohamed Mohamed Elawdy, Yasser Osman, Diaa Eldin Taha, Samer El-Halwagy
OBJECTIVE: Bladder cancer recurrence after management of upper tract urothelial carcinoma (UTUC) is a common disease. Although the incidence and risk factors for the development of noninvasive bladder tumor have been reported in many series, rare studies have reported on muscle invasive bladder cancer (MIBC) and its urethral recurrence. We aimed to report the incidence, risk factors and survival rate for the development of MIBC and urethral tumors after surgical management of UTUC. MATERIAL AND METHODS: We retrospectively reviewed patients who were surgically treated for UTUC from 1983 to 2013...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29732386/naturally-occurring-canine-invasive-urothelial-carcinoma-a-model-for-emerging-therapies
#6
REVIEW
Breann C Sommer, Deepika Dhawan, Timothy L Ratliff, Deborah W Knapp
The development of targeted therapies and the resurgence of immunotherapy offer enormous potential to dramatically improve the outlook for patients with invasive urothelial carcinoma (InvUC). Optimization of these therapies, however, is crucial as only a minority of patients achieve dramatic remission, and toxicities are common. With the complexities of the therapies, and the growing list of possible drug combinations to test, highly relevant animal models are needed to assess and select the most promising approaches to carry forward into human trials...
April 26, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29732157/a-rational-risk-assessment-for-intravesical-recurrence-in-primary-low-grade-ta-bladder-cancer-a-retrospective-analysis-of-245-cases
#7
Masakazu Akitake, Keijiro Kiyoshima, Akira Yokomizo, Kenichiro Shiga, Hirofumi Koga, Ario Takeuchi, Masaki Shiota, Junichi Inokuchi, Katsunori Tatsugami, Akito Yamaguchi, Masatoshi Eto
The aim of the present study was to evaluate the prognostic impact of size and number of tumors in primary low-grade (LG) Ta bladder urothelial carcinoma (UC), and thus allow accurate risk stratification of low-risk non-muscle invasive bladder cancer (NMIBC). This study was a retrospective analysis of 245 patients with primary LG Ta UC of the urinary bladder who were treated with transurethral resection. Differences in intravesical recurrence-free survival (RFS) according to various cutoff values of tumor size and tumor number were calculated using Cox proportional hazards model...
June 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29731899/expression-of-cd74-in-bladder-cancer-and-its-suppression-in-association-with-cancer-proliferation-invasion-and-angiogenesis-in-ht-1376-cells
#8
Jun-Wei Gai, Wasilijiang Wahafu, Liming Song, Hao Ping, Mingshuai Wang, Feiya Yang, Yinong Niu, Wei Qing, Nianzeng Xing
The aim of the present study was to investigate the expression and potential roles of CD74 in human urothelial cell carcinoma of the bladder (UCB) in vitro and in vivo . CD74 and macrophage migration inhibitory factor (MIF) were located and assayed in normal and UCB samples and cell lines using immunostaining. CD74 was knocked down using CD74 shRNA lentiviral particles in HT-1376 cells. The proliferative, invasive potential and microvessel density (MVD) of knockdown-CD74 HT-1376 cells were analyzed in vitro or in vivo ...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29725402/high-expression-of-b7-h3-and-cd163-in-cancer-tissues-indicates-malignant-clinicopathological-status-and-poor-prognosis-of-patients-with-urothelial-cell-carcinoma-of-the-bladder
#9
Zhili Xu, Ling Wang, Jianhua Tian, Hongwei Man, Pengfei Li, Baoen Shan
The objective of the present study was to investigate the association of B7-H3 expression and cluster of differentiation (CD)163+ tumor-associated macrophage (TAM) infiltration with clinicopathological parameters in urothelial cell carcinoma of the bladder (UCB), and to investigate their potential conjoint effects on progression of UCB. B7-H3 expression and CD163+ TAM infiltration in tumor specimens from 134 consecutive patients that underwent radical cystectomy for UCB were tested using immunohistochemistry, followed by statistical analysis...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29724585/urothelial-carcinoma-in-children-a-case-series
#10
Federica Marinoni, Francesca Destro, Giorgio Giuseppe Orlando Selvaggio, Giovanna Riccipetitoni
OBJECTIVE: To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria. MATERIALS AND METHODS: After obtaining ethical and legal authorization, we performed a restrospective monocentric study. We collected information of patients with UBC over a period of 10 years. We recorded: age, sex, reason for presentation, familial history and risk factors, preoperative assessment, surgical details, histological type and grade, follow-up...
April 30, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29724418/acr-appropriateness-criteria-%C3%A2-pretreatment-staging-of-muscle-invasive-bladder-cancer
#11
Christian B van der Pol, V Anik Sahni, Steven C Eberhardt, Aytekin Oto, Oguz Akin, Lauren F Alexander, Brian C Allen, Fergus V Coakley, Adam T Froemming, Pat F Fulgham, Keyanoosh Hosseinzadeh, Jodi K Maranchie, Rekha N Mody, Nicola Schieda, David M Schuster, Aradhana M Venkatesan, Carolyn L Wang, Mark E Lockhart
Muscle-invasive bladder cancer (MIBC) has a tendency toward urothelial multifocality and is at risk for local and distant spread, most commonly to the lymph nodes, bone, lung, liver, and peritoneum. Pretreatment staging of MIBC should include imaging of the urothelial upper tract for synchronous lesions; imaging of the chest, abdomen, and pelvis for metastases; and MRI pelvis for local staging. CT abdomen and pelvis without and with contrast (CT urogram) is recommended to assess the urothelium and abdominopelvic organs...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29699838/perioperative-and-mid-term-oncologic-outcomes-of-robotic-assisted-radical-cystectomy-with-totally-intracorporeal-neobladder-results-of-a-propensity-score-matched-comparison-with-open-cohort-from-a-single-centre-series
#12
Giuseppe Simone, Gabriele Tuderti, Leonardo Misuraca, Umberto Anceschi, Mariaconsiglia Ferriero, Francesco Minisola, Salvatore Guaglianone, Michele Gallucci
AIM: In this study, we compared perioperative and oncologic outcomes of patients treated with either open or robot-assisted radical cystectomy and intracorporeal neobladder at a tertiary care center. METHODS: The institutional prospective bladder cancer database was queried for "cystectomy with curative intent" and "neobladder". All patients underwent robot-assisted radical cystectomy and intracorporeal neobladder or open radical cystectomy and orthotopic neobladder for high-grade non-muscle invasive bladder cancer or muscle invasive bladder cancer with a follow-up length ≥2 years were included...
April 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29699519/comprehensive-gene-expression-analysis-of-canine-invasive-urothelial-bladder-carcinoma-by-rna-seq
#13
Shingo Maeda, Hirotaka Tomiyasu, Masaya Tsuboi, Akiko Inoue, Genki Ishihara, Takao Uchikai, James K Chambers, Kazuyuki Uchida, Tomohiro Yonezawa, Naoaki Matsuki
BACKGROUND: Invasive urothelial carcinoma (iUC) is a major cause of death in humans, and approximately 165,000 individuals succumb to this cancer annually worldwide. Comparative oncology using relevant animal models is necessary to improve our understanding of progression, diagnosis, and treatment of iUC. Companion canines are a preferred animal model of iUC due to spontaneous tumor development and similarity to human disease in terms of histopathology, metastatic behavior, and treatment response...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29696301/-radical-cystectomy-and-urinary-diversion-what-is-important
#14
REVIEW
J Noldus, G Niegisch, A Pycha, A Karl
BACKGROUND: In Germany, radical cystectomy with urinary diversion is the primary therapeutic option for localized muscle invasive urothelial bladder cancer. Modifications in the pre-, peri-, and postoperative phase have significantly improved outcomes. OBJECTIVES: Different factors and parameters are directly associated with patients' outcome. An overview on how to best approach this procedure is provided in this article. MATERIALS AND METHODS: The data regarding preparation and the procedure for the radical cystectomy followed by urinary diversion are separately analyzed...
April 25, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29692504/perioperative-outcomes-of-minimally-invasive-versus-open-radical-cystectomy-a-single-center-experience
#15
Pankaj Panwar, Ravimohan S Mavuduru, Uttam Kumar Mete, Santosh Kumar, Girdhar Singh Bora, Sudheer Kumar Devana, Arup Kumar Mandal, Shrawan Kumar Singh, Nandita Kakkar
Introduction: Open radical cystectomy (RC) is associated with significant morbidity and the role of minimally invasive surgery (MIS) in reducing morbidity of RC is controversial A direct comparison of various surgical modalities on perioperative outcomes is lacking in the Indian literature. We evaluated outcomes of minimally invasive (robotic and laparoscopic) versus open RC with pelvic lymph node dissection (PLND) performed at our institute from 2014 to 2016. Methods: Eighty-three patients of RC with PLND were prospectively analyzed from December 2014 to February 2016...
April 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29650143/perioperative-immunotherapy-in-muscle-invasive-bladder-cancer-and-upper-tract-urothelial-carcinoma
#16
REVIEW
Min Yuen Teo, Jonathan E Rosenberg
Neoadjuvant chemotherapy improves survival in patients with muscle-invasive bladder cancer. However, a significant proportion of patients are ineligible for cisplatin owing to renal impairment or other medical comorbidities. The introduction of anti-programmed cell death protein 1/programmed death-ligand 1(PD1/PD-L1) checkpoint inhibitors has redefined the therapeutic landscape for platinum-resistant urothelial cancers; their clinical efficacy and favorable toxicity render these agents attractive therapeutic options either as monotherapy or in combination with other agents in earlier disease states, including muscle-invasive disease...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29650141/adjuvant-therapy-in-muscle-invasive-bladder-cancer-and-upper-tract-urothelial-carcinoma
#17
REVIEW
Tala Achkar, Rahul A Parikh
This article summarizes the role of adjuvant chemotherapy in muscle-invasive and transitional cell carcinoma of the bladder and upper urinary tract.
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29650138/enhanced-recovery-after-surgery-pathways-role-and-outcomes-in-the-management-of-muscle-invasive-bladder-cancer
#18
REVIEW
Daniel Zainfeld, Ankeet Shah, Siamak Daneshmand
Radical cystectomy remains the gold standard therapy for the treatment of muscle-invasive urothelial carcinoma, yet is accompanied by significant rates of perioperative complications and readmission. Enhanced recovery protocols aim to apply evidence-based principles of care to ameliorate the morbidity of this procedure by enabling better tolerance of and recovery from radical cystectomy. Multiple patient series have demonstrated the capacity for enhanced-recovery-after-surgery (ERAS) principles to improve outcomes among patients undergoing radical cystectomy through decreased incidence of gastrointestinal complications and decreased length of hospitalization without increased readmissions or overall morbidity...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29650137/lymphadenectomy-for-muscle-invasive-bladder-cancer-and-upper-tract-urothelial-cell-carcinoma
#19
REVIEW
Niranjan J Sathianathen, Michael C Risk, Badrinath R Konety
There are currently no reported randomized trials that characterize the staging or therapeutic benefit of performing a lymph node dissection in either bladder cancer or upper tract urothelial carcinoma. Several unanswered questions remain in this domain focused on the indications and patient selection for pelvic lymph node dissection, extent of dissection, its impact on outcome, and potential risks. However, the results of observational studies suggest that the burden of metastasis is high in both diseases when muscle invasive and performing a lymphadenectomy can provide prognostic information and yield therapeutic benefit...
May 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29650132/optimal-timing-of-chemotherapy-and-surgery-in-patients-with-muscle-invasive-bladder-cancer-and-upper-urinary-tract-urothelial-carcinoma
#20
REVIEW
William Tabayoyong, Roger Li, Jianjun Gao, Ashish Kamat
Radical cystectomy with bilateral pelvic lymph node dissection is the standard of care for patients with clinically localized muscle-invasive bladder cancer. Survival after radical cystectomy is associated with final pathologic staging. Survival decreases with increasing pT stage because of the presence of occult micrometastases, indicating the need for systemic chemotherapy. Systemic chemotherapy is delivered as either neoadjuvant therapy preoperatively, or as adjuvant therapy postoperatively. This article reviews the evidence for neoadjuvant and adjuvant chemotherapy for the treatment of muscle-invasive bladder and upper tract urothelial cancer and offers recommendations based on these data and recently updated clinical guidelines...
May 2018: Urologic Clinics of North America
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