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muscle invasive urothelial bladder cancer

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https://www.readbyqxmd.com/read/29349669/positive-correlation-between-matrix-metalloproteinases-and-epithelial-to-mesenchymal-transition-and-its-association-with-clinical-outcome-in-bladder-cancer-patients
#1
R Singh, A Mandhani, V Agrawal, Minal Garg
Involvement of matrix metalloproteinases (MMPs) in the pathogenesis of urothelial carcinoma elects them to be sensitive marker for clinical and prognostic implications. MMPs regulate tumor growth and invasion by inducing epithelial-to-mesenchymal transition (EMT) which is characterized by the complex reprogramming of epithelial cells and ultimately bring about major changes in the structural organization of bladder urothelium. The present study has been undertaken to evaluate the clinical relevance of MMPs in two distinct types of bladder cancer disease...
January 18, 2018: Cancer Microenvironment: Official Journal of the International Cancer Microenvironment Society
https://www.readbyqxmd.com/read/29342465/de-novo-bladder-urothelial-neoplasm-in-renal-transplant-recipients-a-retrospective-multicentered-study
#2
Anna Palazzetti, Andrea Bosio, Ettore Dalmasso, Paolo Destefanis, Fabrizio Fop, Francesca Pisano, Giuseppe Segoloni, Luigi Biancone, Alessandro Volpe, Antonia Di Domenico, Carlo Terrone, Samuele Iesari, Antonio Famulari, Paola Todeschini, Bruno Frea, Paolo Gontero
BACKGROUND AND OBJECTIVES: Renal transplant recipients (RTRs) have a 2- to 7-fold risk of developing a neoplasm compared to general population. Bladder urothelial neoplasms in this cohort has an incidence of 0.4-2%. Many reports describe a more aggressive behavior. The objective of this study is to describe oncologic characteristics of bladder urothelial neoplasms in RTRs and to evaluate its recurrence, progression, and survival rates. METHODS: A retrospective multicentered study was performed evaluating all de novo bladder urothelial neoplasms cases in RTRs from 1988 to 2014...
January 17, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29342309/prognostic-power-of-a-tumor-differentiation-gene-signature-for-bladder-urothelial-carcinomas
#3
Qianxing Mo, Fotis Nikolos, Fengju Chen, Zoe Tramel, Yu-Cheng Lee, Kazukuni Hayashi, Jing Xiao, Jianjun Shen, Keith Syson Chan
Background: Muscle-invasive bladder cancers (MIBCs) cause approximately 150 000 deaths per year worldwide. Survival for MIBC patients is heterogeneous, with no clinically validated molecular markers that predict clinical outcome. Non-MIBCs (NMIBCs) generally have favorable outcome; however, a portion progress to MIBC. Hence, development of a prognostic tool that can guide decision-making is crucial for improving clinical management of bladder urothelial carcinomas. Methods: Tumor grade is defined by pathologic evaluation of tumor cell differentiation, and it often associates with clinical outcome...
January 12, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29329894/neoadjuvant-dose-dense-mvac-versus-gc-in-patients-with-ct3-4an0m0-bladder-cancer-treated-with-radical-cystectomy
#4
Homayoun Zargar, Jay B Shah, Bas W van Rhijn, Siamak Daneshmand, Trinity J Bivalacqua, Philippe E Spiess, Peter C Black, Wassim Kassouf
BACKGROUND: Level I evidence supports the utility of neoadjuvant cisplatin-based chemotherapy (NAC) for muscle invasive bladder cancer (BCa). Since dose dense (ddMVAC) has mostly replaced traditional MVAC, we aimed to compare pathological response and survival rates in patients with locally advanced BCa receiving NAC with ddMVAC versus GC. METHODS: We retrospectively reviewed records of patients with urothelial cancer who received NAC and underwent cystectomy at 20 contributing institutions from 2000-2015...
January 9, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29325739/anti-programmed-cell-death-1-ligand-1-pd-1-pd-l1-antibodies-for-the-treatment-of-urothelial-carcinoma-state-of-the-art-and-future-development
#5
REVIEW
Thomas Powles, Andrea Necchi, Galit Rosen, Subramanian Hariharan, Andrea B Apolo
Immunotherapy with programmed cell death 1/ligand 1 (PD-1/PD-L1) checkpoint inhibitors has expanded a previously limited pool of effective treatment options for patients with metastatic urothelial carcinoma, particularly those with recurring or refractory disease and those who are ineligible for cisplatin. This review reports key findings from completed and ongoing clinical trials that highlight the potential of PD-1/PD-L1 blockade in urothelial carcinoma. A literature search was performed of PubMed, Embase, ClinicalTrials...
December 6, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29323757/differentiation-associated-urothelial-cytochrome-p450-oxidoreductase-predicates-the-xenobiotic-metabolising-activity-of-luminal-muscle-invasive-bladder-cancers
#6
Simon C Baker, Volker M Arlt, Radek Indra, Madeleine Joel, Marie Stiborova, Ian Eardley, Niaz Ahmad, Wolfgang Otto, Maximilian Burger, Peter Rubenwolf, David H Phillips, Jennifer Southgate
Extra-hepatic metabolism of xenobiotics by epithelial tissues has evolved as a self-defence mechanism but has potential to contribute to the local activation of carcinogens. Bladder epithelium (urothelium) is bathed in excreted urinary toxicants and pro-carcinogens. This study reveals how differentiation affects cytochrome P450 (CYP) activity and the role of NADPH:P450 oxidoreductase (POR). CYP1A1 and CYP1B1 transcripts were inducible in normal human urothelial (NHU) cells maintained in both undifferentiated and functional barrier-forming differentiated states in vitro...
January 11, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29323062/role-of-p53-and-ki-67-immunomarkers-in-carcinoma-of-urinary-bladder
#7
Brijesh Thakur, Sanjeev Kishore, Kanika Dutta, Sanjay Kaushik, Aparna Bhardwaj
BACKGROUND: Urothelial carcinoma is common urinary malignancy responsible for a significant proportion of cancer morbidity and mortality. We carried out the present study to demonstrate the clinicohistopathological features and to correlate the p53 and Ki-67 immunoexpression with grade and stage of bladder carcinomas. MATERIALS AND METHODS: We investigated 110 cases of bladder tumor. Grading and staging were done according to the WHO-2004 and American Joint Committee on Cancer-TNM staging recommendations...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29310182/re-increasing-age-is-not-associated-with-toxicity-leading-to-discontinuation-of-treatment-in-patients-with-urothelial-non-muscle-invasive-bladder-cancer-randomised-to-receive-3-years-of-maintenance-bacille-calmette-gu%C3%A3-rin-results-from-european-organisation
#8
https://www.readbyqxmd.com/read/29288007/overexpression-of-semaphorin-3a-in-patients-with-urothelial-cancer
#9
Zahava Vadasz, Jacob Rubinstein, Jacob Bejar, Hilla Sheffer, Sarel Halachmi
OBJECTIVE: A highly sensitive and specific urine marker for the detection of recurrent urothelial cancer and for screening healthy population or people at risk for urothelial cancer has not been found yet. As urine cytology is not sensitive enough, patients with non-muscle-invasive bladder cancer need lifelong follow-up involving multiple invasive cystoscopies. Our aims of study were to examine the expression of semaphorin 3A in urothelial cancer patients and to evaluate semaphorin 3A as a potential marker for urothelial cancer...
December 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29288006/advancements-in-optical-techniques-and-imaging-in-the-diagnosis-and-management-of-bladder-cancer
#10
REVIEW
Tracy L Rose, Yair Lotan
Accurate detection and staging is critical to the appropriate management of urothelial cancer (UC). The use of advanced optical techniques during cystoscopy is becoming more widespread to prevent recurrent nonmuscle invasive bladder cancer. Standard of care for muscle-invasive UC includes the use of computed tomography and/or magnetic resonance imaging, but staging accuracy of these tests remains imperfect. Novel imaging modalities are being developed to improve current test performance. Positron emission tomography/computed tomography has a role in the initial evaluation of select patients with muscle-invasive bladder cancer and in disease recurrence in some cases...
December 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29284232/chromium-in-urothelial-carcinoma-of-the-bladder
#11
Tomasz Golabek, Katarzyna Socha, Jacek Kudelski, Barbara Darewicz, Renata Markiewicz-Zukowska, Piotr Chlosta, Maria Borawska
INTRODUCTION AND OBJECTIVES: Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. However, the involvement of heavy metals in tumourigenesis of urothelial carcinoma of the bladder has been poorly investigated. Therefore, the aim of this study was to examine the relationship between chromium (Cr) and bladder cancer. MATERIAL AND METHODS: Chromium concentration in two 36-sample series of bladder cancer tissue and sera from patients with this neoplasm were matched with those of a control group...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29281857/outcomes-of-subsequent-non-muscle-invasive-bladder-cancer-treated-with-intravesical-bacillus-calmette-gu%C3%A3-rin-after-radical-nephroureterectomy-for-upper-urinary-tract-urothelial-carcinoma-a-propensity-matched-analysis-with-primary-bladder-cancer
#12
Makito Miyake, Yoshihiro Tatsumi, Hiroaki Matsumoto, Kazuhiro Nagao, Hideyasu Matsuyama, Teruo Inamoto, Haruhito Azuma, Hiroaki Yasumoto, Hiroaki Shiina, Kiyohide Fujimoto
OBJECTIVES: To describe the clinicopathologic characteristics and prognosis of subsequent non-muscle invasive bladder cancer (NMIBC) after radical nephroureterectomy for upper urinary tract urothelial carcinoma (UTUC), particularly its response to intravesical Bacillus Calmette-Guérin (BCG). PATIENTS AND METHODS: An observational study was conducted in 1463 patients with UTUC who had undergone radical nephroureterectomy and in 1555 patients with primary NMIBC. Of the 1463 UTUC patients, 256 (17%) subsequently developed NMIBC (UTUC-NMIBC) and were available for the analysis...
December 27, 2017: BJU International
https://www.readbyqxmd.com/read/29281848/propensity-matched-comparative-analysis-of-survival-following-chemoradiation-or-radical-cystectomy-for-muscle-invasive-bladder-cancer
#13
Chad R Ritch, Raymond Balise, Nachiketh Soodana Prakash, David Alonzo, Katherine Almengo, Mahmoud Alameddine, Vivek Venkatramani, Sanoj Punnen, Dipen Parekh, Mark L Gonzalgo
OBJECTIVE: To compare survival outcome between chemoradiation and radical cystectomy for Muscle invasive bladder cancer(MIBC). MATERIALS AND METHODS: A retrospective analysis was performed using muscle-invasive bladder cancer (≥cT2, N0, M0) patients in the National Cancer Database (2004-2013). Chemoradiation was defined as radiation dose ≥40Gy and chemotherapy within 90d of radiation. Descriptive statistics were used to compare groups. Radical cystectomy and chemoradiation patients were propensity matched...
December 27, 2017: BJU International
https://www.readbyqxmd.com/read/29277583/wisp1-genetic-variants-as-predictors-of-tumor-development-with-urothelial-cell-carcinoma
#14
Hsiang-Lin Lee, Hui-Ling Chiou, Shian-Shiang Wang, Sheng-Chun Hung, Ming-Chih Chou, Shun-Fa Yang, Ming-Ju Hsieh, Ying-Erh Chou
OBJECTIVES: Urothelial cell carcinoma (UCC) of the urinary bladder is a major malignancy of the genitourinary tract. Etiological factors, such as the environment, ethnicity, genetics, and diet, contribute to UCC carcinogenesis. WNT1-inducible signaling pathway protein 1 (WISP1), also known as CCN4, a cysteine-rich protein belonging to the Cyr61, CTGF, Nov (CCN) family of matricellular proteins, has many developmental functions and might be involved in carcinogenesis. This study investigated WISP1 single-nucleotide polymorphisms to evaluate UCC susceptibility and clinicopathological characteristics...
December 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29249035/clinicopathologic-and-immunohistochemical-study-of-combined-small-cell-carcinoma-and-urothelial-carcinoma-molecular-subtype
#15
Guang-Qian Xiao, Mary M Barrett, Qi Yang, Pamela D Unger
Muscle invasive bladder cancer, an aggressive disease with heterogeneous molecular profiles, has recently been subclassified into three major molecular subtypes -basal, luminal and "p53-like" urothelial carcinomas (UCas), which bear prognostic and therapeutic implication. Similar to breast cancer, basal and luminal subtype UCas are designated by basal (CK5/14) and luminal (CK20) markers. The "p53-like" subtype presents with wild-type p53 gene with upregulated p53 pathways and is implicated in chemoresistance...
December 16, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29241311/a-larger-detrusor-wall-thickness-increases-the-risk-of-non-muscle-invasive-bladder-cancer-recurrence-and-progression-result-from-a-multicenter-observational-study
#16
Antonio Cicione, Stefano Manno, Giuseppe Ucciero, Francesco Cantiello, Rocco Damiano, Estevao Lima, Alessandro Posti, Filippo Balloni, Cosimo DE Nunzio
BACKGROUND: Recent experimental study showed a higher incidence of bladder cancer in presence of bladder detrusor muscle thickening. The aim of this study is to assess whether a higher detrusor muscle thickness (DWT) may be a risk factor of recurrence of non-muscle invasive urothelial bladder cancer (NMIBC). METHODS: Men with histologically-confirmed diagnosis of NMIBC were prospectively enrolled in 4 centers between December 2015 and April 2017. DWT was measured by ultrasound and DWT>2...
December 14, 2017: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29238204/low-expression-of-dab2ip-predicts-an-unfavorable-prognosis-in-human-bladder-carcinoma
#17
Linfeng Zheng, Kaiyan Chen, Liang Zhu, Dan Su, Guoping Cheng
The DOC-2/DAB2 interactive protein (DAB2IP) is a novel member of the Ras GTPase-activating protein family, and its downregulation is an unfavorable prognostic factor in several human malignancies. In this study, we retrospectively analyzed clinicopathological features, outcomes, and DAB2IP expression in 77 patients with urothelial carcinoma of the bladder (UCB). Expression of DAB2IP and p-STAT3 was examined in tumors and in matched adjacent non-cancerous tissues, using immunohistochemistry. We found a marked reduction in the expression of DAB2IP in UCB specimens, which was significantly associated with advanced pathological stage (P=0...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29232802/-sarcomatoid-urothelial-carcinoma-of-the-bladder-including-an-osteosarcoma-element
#18
Kouzaburou Tanuma, Koji Kawai, Haruki Tsuchiya, Yoshitaka Matsumoto, Shuya Kandori, Takahiro Kojima, Tomokazu Kimura, Akira Joraku, Jun Miyazaki, Hiroyuki Nishiyama, Akiko Sakata
A 68-year-old Japanese man was referred to Tsukuba University Hospital for bladder cancer treatment. He had undergone a transurethral resection of a bladder tumor (TURBT) at a local hospital, but the pathological specimen did not contain muscle layer. Abdominal computed tomography (CT) and magnetic resonance imaging revealed a 3 cm non-papillary bladder tumor with muscle invasion, but there was no apparent calcification. The patient underwent re-TURBT at our hospital for diagnosis and staging. A non-papillary pedunculated tumor was identified in the bladder dome, and it contained a small papillary part...
November 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29207636/characterization-of-urinary-extracellular-vesicle-proteins-in-muscle-invasive-bladder-cancer
#19
Christopher R Silvers, Hiroshi Miyamoto, Edward M Messing, George J Netto, Yi-Fen Lee
The mechanisms of bladder cancer progression are unknown, and new treatments and biomarkers are needed. Patient urinary extracellular vesicles (EVs) derive in part from bladder cancer cells and contain a specific protein cargo which may provide information about the disease. We conducted a proteomics study comparing EVs from the muscle-invasive bladder cancer (MIBC) cell line TCCSUP to EVs from normal urothelial line SVHUC. GO term analysis showed that TCCSUP EVs are enriched in proteins associated with the cell membrane, extracellular matrix, and inflammation and angiogenesis signaling pathways...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29199023/the-current-status-and-future-role-of-the-phosphoinositide-3-kinase-akt-signaling-pathway-in-urothelial-cancer-an-old-pathway-in-the-new-immunotherapy-era
#20
REVIEW
Sandy T Liu, Gavin Hui, Colleen Mathis, Karim Chamie, Allan J Pantuck, Alexandra Drakaki
The phosphoinositide 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway is a well studied signaling pathway that regulates diverse cellular functions including proliferation, metabolism, and transcription. Aberrant activation of this pathway has been implicated in multiple cancers. Genomic studies have shown that activating mutations in oncogenes as well as inactivating mutations in tumor suppressor genes are present across a variety of malignancies, including urothelial carcinoma...
November 3, 2017: Clinical Genitourinary Cancer
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