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https://www.readbyqxmd.com/read/29145838/mri-characteristics-for-phantom-scratching-in-canine-syringomyelia
#1
Zoe R Nalborczyk, Angus K McFadyen, Jelena Jovanovik, Anna Tauro, Colin J Driver, Noel Fitzpatrick, Susan P Knower, Clare Rusbridge
BACKGROUND: A classic sign of canine syringomyelia (SM) is scratching towards one shoulder. Using magnetic resonance imaging (MRI) we investigate the spinal cord lesion relating to this phenomenon which has characteristics similar to fictive scratch secondary to spinal cord transection. Medical records were searched for Cavalier King Charles spaniels with a clinical and MRI diagnosis of symptomatic SM associated with Chiari-like malformation (CM). The cohort was divided into SM with phantom scratching (19 dogs) and SM but no phantom scratching (18 dogs)...
November 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29138745/spontaneous-nervous-system-concussion-in-dogs-a-description-of-two-cases-and-a-review-of-terminology-in-veterinary-medicine
#2
Angelo Pasquale Giannuzzi, Antonio De Simone, Mario Ricciardi
In human medicine, central nervous system (CNS) concussion is defined as a transient neurological dysfunction following a traumatic event, without evidence of structural abnormalities of the affected region on advanced diagnostic imaging. Depending on the anatomical region involved, three forms of concussive syndromes are described: brain concussion, spinal concussion and cerebellar concussion. Although major textbooks of veterinary neurology admit the existence of canine brain concussion, spontaneous cases of this pathological condition have not been reported in small animals so far...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29111148/effects-of-opioid-and-nonopioid-analgesics-on-canine-wheal-formation-and-cultured-human-mast-cell-degranulation
#3
Eric Schmidt-Rondon, Zhenping Wang, Shelle A Malkmus, Anna Di Nardo, Keith Hildebrand, Linda Page, Tony L Yaksh
Mast cell (MC) degranulation has been implicated in the side effect profile of a variety of clinically useful agents. Thus, after intrathecal delivery, formation of space-occupying, meningeally-derived masses may be related to local MC degranulation. We systematically characterized degranulating effects of opioid and nonopioid analgesics on cutaneous flares in the dog and in primary human MC (hMC) cultures. METHODS: Dogs were anesthetized with IV propofol and received intradermal (ID) injections (50μL)...
October 27, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29099681/beyond-the-laboratory-into-the-clinic-what-dogs-with-disk-disease-have-taught-us-about-photobiomodulation-for-spinal-cord-injury
#4
Narda G Robinson
BACKGROUND: For spinal-cord-injured (SCI) patients, integrative medicine approaches such as photomedicine and acupuncture can renew hope and offer previously unrecognized ways to help regain function and improve quality of life. OBJECTIVE: By understanding the mechanisms of action that these two modalities share, practitioners can better target specific attributes of spinal cord pathophysiology that are limiting recovery. Naturally occurring intervertebral disk disease (IVDD) in dogs affords unparalleled translational opportunities to develop treatment strategies involving photobiomodulation and acupuncture...
November 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29074336/the-role-of-fenestration-in-management-of-type-i-thoracolumbar-disk-degeneration
#5
REVIEW
Nick D Jeffery, Paul M Freeman
Fenestration offers the advantages of prophylaxis without the need for specialized instrumentation and imaging. Currently there is a lack of equipoise regarding the efficacy of fenestration relative to decompression for treatment of acute canine intervertebral disk herniation; most veterinary spinal surgeons do not consider the 2 procedures equivalently efficacious. Therapeutic fenestration should perhaps be given greater consideration, especially if advanced imaging shows only mild to moderate spinal cord compression or there are restrictions on the duration of surgery, when it might be better to spend the time on fenestration rather than decompression...
October 23, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29037433/minimally-invasive-spine-surgery-in-small-animals
#6
REVIEW
Bianca F Hettlich
Minimally invasive spine surgery (MISS) seems to have many benefits for human patients and is currently used for various minor and major spine procedures. For MISS, a change in access strategy to the target location is necessary and it requires intraoperative imaging, special instrumentation, and magnification. Few veterinary studies have evaluated MISS for canine patients for spinal decompression procedures. This article discusses the general requirements for MISS and how these can be applied to veterinary spinal surgery...
October 13, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/28974151/the-relationship-between-lesion-severity-characterized-by-diffusion-tensor-imaging-and-motor-function-in-chronic-canine-spinal-cord-injury
#7
Melissa J Lewis, Pew-Thian Yap, Susan McCullough, Natasha J Olby
Lesion heterogeneity among chronically paralyzed dogs after acute, complete thoracolumbar spinal cord injury (TLSCI) is poorly described. We hypothesized that lesion severity quantified by diffusion tensor imaging (DTI) is associated with hindlimb motor function. Our objectives were to quantify lesion severity with fractional anisotropy (FA), mean diffusivity (MD), and tractography and investigate associations with motor function. Twenty-two dogs with complete TLSCI in the chronic stage were enrolled and compared with six control dogs...
November 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28919363/thoracic-spinal-cord-and-cervical-vagosympathetic-neuromodulation-obtund-nodose-sensory-transduction-of-myocardial-ischemia
#8
Siamak Salavatian, Eric Beaumont, David Gibbons, Matthew Hammer, Donald B Hoover, J Andrew Armour, Jeffrey L Ardell
BACKGROUND: Autonomic regulation therapy involving either vagus nerve stimulation (VNS) or spinal cord stimulation (SCS) represents emerging bioelectronic therapies for heart disease. The objective of this study was to determine if VNS and/or SCS modulate primary cardiac afferent sensory transduction of the ischemic myocardium. METHODS: Using extracellular recordings in 19 anesthetized canines, of 88 neurons evaluated, 36 ventricular-related nodose ganglia sensory neurons were identified by their functional activity responses to epicardial touch, chemical activation of their sensory neurites (epicardial veratridine) and great vessel (descending aorta or inferior vena cava) occlusion...
August 18, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28886118/in-vivo-experimental-study-of-anterior-cervical-fusion-using-bioactive-polyetheretherketone-in-a-canine-model
#9
Takayoshi Shimizu, Shunsuke Fujibayashi, Seiji Yamaguchi, Bungo Otsuki, Yaichiro Okuzu, Tomiharu Matsushita, Tadashi Kokubo, Shuichi Matsuda
BACKGROUND: Polyetheretherketone (PEEK) is a widely accepted biomaterial, especially in the field of spinal surgery. However, PEEK is not able to directly integrate with bone tissue, due to its bioinertness. To overcome this drawback, various studies have described surface coating approaches aimed at increasing the bioactivity of PEEK surfaces. Among those, it has been shown that the recently developed sol-gel TiO2 coating could provide PEEK with the ability to bond with bone tissue in vivo without the use of a bone graft...
2017: PloS One
https://www.readbyqxmd.com/read/28865227/pathological-findings-in-low-field-magnetic-resonance-imaging-of-the-canine-spine-a-study-of-112-patients
#10
P Holak, J Głodek, M Mieszkowska, M Jałyński, Y Zhalniarovich, Z Adamiak
Magnetic resonance imaging (MRI) is a method of choice in diagnosing nervous system disorders. This paper presents the results of a study where selected segments of the canine spine were examined by low-field MRI in 112 patients. Images of pathological changes were obtained in spin echo (SE), fast spin echo (FSE) and hybrid contrast enhancement (3D HYCE) sequences. The cervical region of the spinal cord (C1-C5) was examined in 32 patients, the cervicothoracic region (C6-Th2)- in 14 patients, the thoracolumbar region (Th3-L3) - in 23 patients, and the lumbosacral region (L4-S3) - in 43 patients...
March 1, 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28809631/-comparison-between-the-range-of-movement-canine-real-cervical-spine-and-numerical-simulation-computer-model-validation
#11
R Srnec, Z Horák, R Sedláček, M Sedlinská, M Krbec, A Nečas
PURPOSE OF THE STUDY In developing new or modifying the existing surgical treatment methods of spine conditions an integral part of ex vivo experiments is the assessment of mechanical, kinematic and dynamic properties of created constructions. The aim of the study is to create an appropriately validated numerical model of canine cervical spine in order to obtain a tool for basic research to be applied in cervical spine surgeries. For this purpose, canine is a suitable model due to the occurrence of similar cervical spine conditions in some breeds of dogs and in humans...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28762382/spontaneous-acute-and-chronic-spinal-cord-injuries-in-paraplegic-dogs-a-comparative-study-of-in-vivo-diffusion-tensor-imaging
#12
A Wang-Leandro, M K Hobert, N Alisauskaite, P Dziallas, K Rohn, V M Stein, A Tipold
STUDY DESIGN: Prospective observational-analytical study. OBJECTIVES: Description of diffusion tensor imaging (DTI) metrics obtained from the spinal cord (SC) of dogs with severe acute or chronic spontaneous, non-experimentally induced spinal cord injury (SCI) and correlation of DTI values with lesion extent of SCI measured in T2-weighted (T2W) magnetic resonance imaging sequences. SETTING: Hannover, Germany. METHODS: Forty-seven paraplegic dogs, 32 with acute and 15 with chronic SCI, and 6 disease controls were included...
August 1, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28757523/operative-techniques-of-percutaneous-endoscopic-mini-hemilaminectomy-using-a-uniportal-approach-in-dogs
#13
Hee-Sup Moon, Yong-Hyun Hwang, Hee-Chun Lee, Jae-Hoon Lee
The present study aimed to investigate the technical feasibility of percutaneous endoscopic mini-hemilaminectomy via a uniportal approach, and to evaluate the possibility of decompression and endoscopic examination of the thoracic and lumbar spinal canals in small dogs during such procedures. Fresh canine cadavers of mixed-breed dogs (n=7) were used in this study. Following injection of a barium and agarose mixture (BA-gel) to stimulate intervertebral disc herniation, percutaneous endoscopic mini-hemilaminectomy was performed using a lateral approach to the thoracic and lumbar vertebrae...
September 12, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28726160/complete-canine-spinal-cord-transection-model-a-large-animal-model-for-the-translational-research-of-spinal-cord-regeneration
#14
Sufang Han, Xing Li, Zhifeng Xiao, Jianwu Dai
No abstract text is available yet for this article.
July 18, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28715613/isolation-and-characterization-of-canine-placenta-derived-mesenchymal-stromal-cells-for-the-treatment-of-neurological-disorders-in-dogs
#15
Connor Long, Lee Lankford, Priyadarsini Kumar, Robert Grahn, Dori L Borjesson, Diana Farmer, Aijun Wang
Spinal cord injury (SCI) is a devastating disorder that affects humans and dogs. The prognosis of SCI depends on the severity of the injury and can include varying levels of motor and sensory deficits including devastating paraplegia and quadriplegia. Placental mesenchymal stromal cells (PMSCs) have been shown to improve wound healing and possess neuroprotective and immunomodulatory capabilities, but have not yet been clinically tested for the treatment of SCI. This study established a protocol to isolate fetal PMSCs from canine placentas and characterized their paracrine secretion profile and ability to stimulate neurons in vitro to assess their potential as a treatment option for neurological disorders in dogs...
July 17, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28700706/spatial-distribution-of-cannabinoid-receptor-type-1-cb1-in-normal-canine-central-and-peripheral-nervous-system
#16
Jessica Freundt-Revilla, Kristel Kegler, Wolfgang Baumgärtner, Andrea Tipold
The endocannabinoid system is a regulatory pathway consisting of two main types of cannabinoid receptors (CB1 and CB2) and their endogenous ligands, the endocannabinoids. The CB1 receptor is highly expressed in the central and peripheral nervous systems (PNS) in mammalians and is involved in neuromodulatory functions. Since endocannabinoids were shown to be elevated in cerebrospinal fluid of epileptic dogs, knowledge about the species specific CB receptor expression in the nervous system is required. Therefore, we assessed the spatial distribution of CB1 receptors in the normal canine CNS and PNS...
2017: PloS One
https://www.readbyqxmd.com/read/28650240/development-of-a-clinical-spasticity-scale-for-evaluation-of-dogs-with-chronic-thoracolumbar-spinal-cord-injury
#17
Melissa J Lewis, Natasha J Olby
OBJECTIVE To develop a spasticity scale for dogs with chronic deficits following severe spinal cord injury (SCI) for use in clinical assessment and outcome measurement in clinical trials. ANIMALS 20 chronically paralyzed dogs with a persistent lack of hind limb pain perception caused by an acute SCI at least 3 months previously. PROCEDURES Spasticity was assessed in both hind limbs via tests of muscle tone, clonus, and flexor and extensor spasms adapted from human scales. Measurement of patellar clonus duration and flexor spasm duration and degree was feasible...
July 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28645289/degenerative-changes-of-the-canine-cervical-spine-after-discectomy-procedures-an-in-vivo-study
#18
Peter Grunert, Yu Moriguchi, Brian P Grossbard, Rodolfo J Ricart Arbona, Lawrence J Bonassar, Roger Härtl
BACKGROUND: Discectomies are a common surgical treatment for disc herniations in the canine spine. However, the effect of these procedures on intervertebral disc tissue is not fully understood. The objective of this study was to assess degenerative changes of cervical spinal segments undergoing discectomy procedures, in vivo. RESULTS: Discectomies led to a 60% drop in disc height and 24% drop in foraminal height. Segments did not fuse but showed osteophyte formation as well as endplate sclerosis...
June 23, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28613324/a-fusion-of-minicircle-dna-and-nanoparticle-delivery-technologies-facilitates-therapeutic-genetic-engineering-of-autologous-canine-olfactory-mucosal-cells
#19
Alexander M Delaney, Christopher F Adams, Alinda R Fernandes, Arwa F Al-Shakli, Jon Sen, Darren R Carwardine, Nicolas Granger, Divya M Chari
Olfactory ensheathing cells (OECs) promote axonal regeneration and improve locomotor function when transplanted into the injured spinal cord. A recent clinical trial demonstrated improved motor function in domestic dogs with spinal injury following autologous OEC transplantation. Their utility in canines offers promise for human translation, as dogs are comparable to humans in terms of clinical management and genetic/environmental variation. Moreover, the autologous, minimally invasive derivation of OECs makes them viable for human spinal injury investigation...
June 29, 2017: Nanoscale
https://www.readbyqxmd.com/read/28611846/safety-of-allogeneic-canine-adipose-tissue-derived-mesenchymal-stem-cell-intraspinal-transplantation-in-dogs-with-chronic-spinal-cord-injury
#20
Cláudia Cardoso Maciel Escalhão, Isalira Peroba Ramos, Camila Hochman-Mendez, Tais Hanae Kasai Brunswick, Sergio Augusto Lopes Souza, Bianca Gutfilen, Regina Coeli Dos Santos Goldenberg, Tatiana Coelho-Sampaio
This is a pilot clinical study primarily designed to assess the feasibility and safety of X-ray-guided percutaneous intraspinal injection of allogeneic canine adipose tissue-derived mesenchymal stem cells in dogs with chronic spinal cord injury. Six dogs with chronic paraplegia (≥six months) were intraparenchymally injected with allogeneic cells in the site of lesion. Cells were obtained from subcutaneous adipose tissue of a healthy dog, cultured to passage 3, labeled with (99m)Technetium, and transplanted into the lesion by percutaneous X-ray-guided injection...
2017: Stem Cells International
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