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Feline intracranial

Maria Teresa Mandara, Luca Motta, Pietro Calò
In cats, lymphoma (lymphosarcoma) is the most common neoplasm affecting the spinal cord and the second most common intracranial tumour. Although lymphoma commonly develops in the spinal cord as a part of a multicentric process, a primary form may occur. Lymphoma can exhibit a wide range of morphological patterns, including intraparenchymal brain mass, lymphomatosis cerebri, intravascular lymphoma, lymphomatous choroiditis and meningitis, extradural, intradural-extramedullary or intramedullary lymphoma in the spinal cord, or neurolymphomatosis in the peripheral nerves...
October 2016: Veterinary Journal
Heather L Gray-Edwards, Brandon L Brunson, Merrilee Holland, Adrien-Maxence Hespel, Allison M Bradbury, Victoria J McCurdy, Patricia M Beadlescomb, Ashley N Randle, Nouha Salibi, Thomas S Denney, Ronald J Beyers, Aime K Johnson, Meredith L Voyles, Ronald D Montgomery, Diane U Wilson, Judith A Hudson, Nancy R Cox, Henry J Baker, Miguel Sena-Esteves, Douglas R Martin
Sandhoff disease (SD) is a fatal neurodegenerative disease caused by a mutation in the enzyme β-N-acetylhexosaminidase. Children with infantile onset SD develop seizures, loss of motor tone and swallowing problems, eventually reaching a vegetative state with death typically by 4years of age. Other symptoms include vertebral gibbus and cardiac abnormalities strikingly similar to those of the mucopolysaccharidoses. Isolated fibroblasts from SD patients have impaired catabolism of glycosaminoglycans (GAGs). To evaluate mucopolysaccharidosis-like features of the feline SD model, we utilized radiography, MRI, echocardiography, histopathology and GAG quantification of both central nervous system and peripheral tissues/fluids...
September 2015: Molecular Genetics and Metabolism
V J McCurdy, H E Rockwell, J R Arthur, A M Bradbury, A K Johnson, A N Randle, B L Brunson, M Hwang, H L Gray-Edwards, N E Morrison, J A Johnson, H J Baker, N R Cox, T N Seyfried, M Sena-Esteves, D R Martin
Sandhoff disease (SD) is caused by deficiency of N-acetyl-β-hexosaminidase (Hex) resulting in pathological accumulation of GM2 ganglioside in lysosomes of the central nervous system (CNS) and progressive neurodegeneration. Currently, there is no treatment for SD, which often results in death by the age of five years. Adeno-associated virus (AAV) gene therapy achieved global CNS Hex restoration and widespread normalization of storage in the SD mouse model. Using a similar treatment approach, we sought to translate the outcome in mice to the feline SD model as an important step toward human clinical trials...
February 2015: Gene Therapy
Allison M Bradbury, Heather L Gray-Edwards, Jamie L Shirley, Victoria J McCurdy, Alexandria N Colaco, Ashley N Randle, Pete W Christopherson, Allison C Bird, Aime K Johnson, Diane U Wilson, Judith A Hudson, Nicholas L De Pompa, Donald C Sorjonen, Brandon L Brunson, Mylvaganam Jeyakumar, Frances M Platt, Henry J Baker, Nancy R Cox, Miguel Sena-Esteves, Douglas R Martin
The GM2 gangliosidoses, Tay-Sachs disease (TSD) and Sandhoff disease (SD), are progressive neurodegenerative disorders that are caused by a mutation in the enzyme β-N-acetylhexosaminidase (Hex). Due to the recent emergence of novel experimental treatments, biomarker development has become particularly relevant in GM2 gangliosidosis as an objective means to measure therapeutic efficacy. Here we describe blood, cerebrospinal fluid (CSF), magnetic resonance imaging (MRI), and electrodiagnostic methods for evaluating disease progression in the feline SD model and application of these approaches to assess AAV-mediated gene therapy...
January 2015: Experimental Neurology
Daisuke Hasegawa, Shunta Mizoguchi, Takayuki Kuwabara, Yuji Hamamoto, Fukie Ogawa, Naoaki Matsuki, Kazuyuki Uchida, Michio Fujita
A feline strain of familial spontaneous epileptic cats (FSECs) with typical limbic seizures was identified in 2010, and have been maintained as a novel animal model of genetic epilepsy. In this study, we characterized the electroencephalographic (EEG) features of FSECs. On scalp EEG under sedation, FSECs showed sporadic, but comparatively frequent interictal discharges dominantly in the uni- or bilateral temporal region. Bemegride activation was performed in order to evaluate the predisposition of epileptogenicity of FSECs...
August 2014: Epilepsy Research
Amy W Hodshon, Silke Hecht, William B Thomas
T2*-weighted magnetic resonance imaging (MRI) has been reported to help improve detection of intracranial hemorrhage and is widely used in human neuroimaging. To assess the utility of this technique in small animals, interpretations based on this sequence were compared with those based on paired T2-weighted and fluid-attenuated inversion recovery (FLAIR) sequences in 200 dogs and cats that underwent brain MRI for suspected intracranial disease. Two sets of images (T2 + FLAIR and T2*) were reviewed separately in random order unaccompanied by patient information and were interpreted as normal or abnormal based on whether intracranial abnormalities were seen...
November 2014: Veterinary Radiology & Ultrasound
Victoria J McCurdy, Aime K Johnson, Heather L Gray-Edwards, Ashley N Randle, Brandon L Brunson, Nancy E Morrison, Nouha Salibi, Jacob A Johnson, Misako Hwang, Ronald J Beyers, Stanley G Leroy, Stacy Maitland, Thomas S Denney, Nancy R Cox, Henry J Baker, Miguel Sena-Esteves, Douglas R Martin
Progressive debilitating neurological defects characterize feline G(M1) gangliosidosis, a lysosomal storage disease caused by deficiency of lysosomal β-galactosidase. No effective therapy exists for affected children, who often die before age 5 years. An adeno-associated viral vector carrying the therapeutic gene was injected bilaterally into two brain targets (thalamus and deep cerebellar nuclei) of a feline model of G(M1) gangliosidosis. Gene therapy normalized β-galactosidase activity and storage throughout the brain and spinal cord...
April 9, 2014: Science Translational Medicine
Katherine M Simpson, Luisa De Risio, Anita Theobald, Laurent Garosi, Mark Lowrie
All previous studies on feline ischaemic myelopathy (IM) have reported an acute onset of a single event with no recurrence of clinical signs. This study aimed to evaluate clinical and long-term follow-up data in cats presumptively diagnosed with cervical IM in the territory of the ventral spinal artery (VSA). Eight cats (four females and four males) were included with a mean age of 14 years and 2 months. Neurological status at the time of presentation ranged from ambulatory tetraparesis to tetraplegia with nociception present...
December 2014: Journal of Feline Medicine and Surgery
E J Ives, N Rousset, N Heliczer, M E Herrtage, A E Vanhaesebrouck
BACKGROUND: No evidence-based guidelines are available for the administration of gadolinium-based contrast media to veterinary patients. OBJECTIVE: To investigate whether administration of intravenous (IV) contrast media alters the likelihood of identifying a brain lesion in dogs and cats. ANIMALS: Four hundred and eighty-seven client-owned animals referred for investigation of intracranial disease. METHODS: Two reviewers retrospectively analyzed precontrast transverse and sagittal T1-weighted (T1W), T2-weighted, and fluid-attenuated inversion recovery low-field MRI sequences from each patient for the presence of a clinically relevant brain lesion...
March 2014: Journal of Veterinary Internal Medicine
F Crop, T Lacornerie, H Szymczak, A Felin, C Bailleux, X Mirabel, E Lartigau
The purpose of this study is to obtain a better operational knowledge of Stereotactic Body Radiotherapy (SBRT) treatments with CyberKnife(r). An analysis of both In-room Times (IRT) and technical interventions of 5 years of treatments was performed, during which more than 1600 patients were treated for various indications, including liver (21%), lung (29%), intracranial (13%), head and neck (11%) and prostate (7%). Technical interventions were recorded along with the time of the failure, time to the intervention, and the complexity and duration of the repair...
February 2014: Technology in Cancer Research & Treatment
Allison M Bradbury, J Nicholas Cochran, Victoria J McCurdy, Aime K Johnson, Brandon L Brunson, Heather Gray-Edwards, Stanley G Leroy, Misako Hwang, Ashley N Randle, Laura S Jackson, Nancy E Morrison, Rena C Baek, Thomas N Seyfried, Seng H Cheng, Nancy R Cox, Henry J Baker, M Begona Cachón-González, Timothy M Cox, Miguel Sena-Esteves, Douglas R Martin
Salutary responses to adeno-associated viral (AAV) gene therapy have been reported in the mouse model of Sandhoff disease (SD), a neurodegenerative lysosomal storage disease caused by deficiency of β-N-acetylhexosaminidase (Hex). While untreated mice reach the humane endpoint by 4.1 months of age, mice treated by a single intracranial injection of vectors expressing human hexosaminidase may live a normal life span of 2 years. When treated with the same therapeutic vectors used in mice, two cats with SD lived to 7...
July 2013: Molecular Therapy: the Journal of the American Society of Gene Therapy
Philemon Karli, Daniela Gorgas, Anna Oevermann, Franck Forterre
Meningioma is the most frequently observed primary brain tumour in cats. Usually, it is associated with an intracranial expansion with consequent brain compression, oedema and brain herniation. Typical features of feline intracranial meningiomas are hyperostosis of the adjacent bone and intratumoral mineralisation. We describe a 13-year-old male neutered cat with a 1-year history of behavioural change. At clinical and neurological examination the cat showed signs consistent with right-sided forebrain lesion...
August 2013: Journal of Feline Medicine and Surgery
Luca Motta, Maria Teresa Mandara, Geoffrey C Skerritt
Meningiomas are the most common primary brain tumours in dogs and cats. There are several morphological phenotypes of this extra-axial neoplasm and they show predilections for certain anatomical locations. There have been a number of attempts to apply the current World Health Organization (WHO) classification for human meningiomas to dogs and cats and to obtain a universal classification scheme for domestic animals. Recently, certain enzymes involved in tumour growth have been recognised as biological markers and have been related to degrees of malignancy...
May 2012: Veterinary Journal
Frédéric Goulle, Frédéric Meige, Franck Durieux, Christophe Malet, Olivier Toulza, Pierre-François Isard, Robert L Peiffer, Thomas Dulaurent
OBJECTIVE: To describe a case of intracranial meningioma causing visual impairment in a cat, successfully treated by surgery. PROCEDURES: An adult neutered male domestic cat was referred with a 10-month history of progressive visual impairment and altered behavior. Investigations included physical, ophthalmologic and neurological examinations as well as hematology, serum biochemistry and CT scan of the head. RESULTS: The menace response was absent in the left eye and decreased in the right eye...
September 2011: Veterinary Ophthalmology
Micki D Armour, Michael Broome, Giuseppe Dell'Anna, Natalie J Blades, Douglas W Esson
OBJECTIVE: To review the distribution of orbital and intracranial disease in canine and feline patients undergoing magnetic resonance imaging (MRI) following referral to a veterinary ophthalmologist and to correlate results of MRI with pathologic conditions including neoplasia, suspected optic neuritis (ON) and orbital cellulitis. Recognized and emerging imaging techniques are reviewed. PROCEDURE: Medical records of 79 canine and 13 feline patients were reviewed...
July 2011: Veterinary Ophthalmology
Rodrigo Gutierrez-Quintana, Danièlle A Gunn-Moore, Catherine G Lamm, Jacques Penderis
Skull hyperostosis is a frequently recognised feature of meningioma in feline and human patients, occurring at a frequency of around 4.5% of human cases. Evidence of osteolysis with extension of meningioma into, and in some cases through, the region of skull hyperostosis is much less commonly described in human patients. Here we present a 12-year-old cat with marked skull hyperostosis secondary to an intracranial meningioma, with magnetic resonance imaging and computed tomography evidence of tumour extension into the skull, centrally within the region of hyperostosis...
April 2011: Journal of Feline Medicine and Surgery
Ulrike Michal Altay, Geoff C Skerritt, Monika Hilbe, Felix Ehrensperger, Frank Steffen
Sixteen cats with cerebrovascular disease confirmed via histology to be of nontraumatic and nonneoplastic origins are described. In addition, the anatomy of the arterial supply of the cat's brain is reviewed. It is suggested that this unique arterial design may influence the incidence of cerebrovascular accidents in this species. Of the 16 cats reviewed, seven cats had ischemic infarctions, five had hemorrhagic infarctions, and four were diagnosed with intracranial hemorrhage. The median age was 8 yr and 9...
March 2011: Journal of the American Animal Hospital Association
Jocelyn J Cooper, Benjamin D Young, Anton Hoffman, Gerald Bratton, Daniel G Hicks, Amy Tidwell, Jonathan M Levine
Normal anatomic variation, study design, external factors, and tissue characteristics can all influence the manifestation of structures on magnetic resonance images (MRI). For the purpose of this review, imaging artifacts are considered to be nonpathologic abnormalities resulting from study design, intrinsic tissue characteristics, or external factors, while MRI pseudolesions are due to normal anatomic variation. Awareness of imaging artifacts and pseudolesions, as well as normal anatomic structures, is important when determining pathologic vs...
November 2010: Veterinary Radiology & Ultrasound
A J Pattison, S S Lollis, P R Perriñez, I M Perreard, M D J McGarry, J B Weaver, K D Paulsen
Imaging of the mechanical properties of in vivo brain tissue could eventually lead to non-invasive diagnosis of hydrocephalus, Alzheimer's disease and other pathologies known to alter the intracranial environment. The purpose of this work is to (1) use time-harmonic magnetic resonance elastography (MRE) to estimate the mechanical property distribution of cerebral tissue in the normal feline brain and (2) compare the recovered properties of grey and white matter. Various in vivo and ex vivo brain tissue property measurement strategies have led to the highly variable results that have been reported in the literature...
October 19, 2010: Journal of Biomechanics
Stijn J M Niessen
PRACTICAL RELEVANCE: Clinicians who deal with diabetic cats can have mixed experiences. Some patients are 'textbook cases', responding very well to insulin administration; others prove to be more challenging. Recent studies have shown a significant proportion of problem diabetic cats to have underlying acromegaly (hypersomatotropism). Recognising this syndrome in these cats will be key to successfully managing the concurrent diabetes. PATIENT GROUP: Just like the 'normal' (non-acromegalic) diabetic cat, the acromegalic diabetic cat tends to be a middle-aged to older male neutered domestic short hair...
January 2010: Journal of Feline Medicine and Surgery
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