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Canine intracranial

Bu-Lang Gao, Yong-Li Wang, Xue-Jing Zhang, Qiong-Ying Fan, Wei-Li Hao, Dong-Hai Zhang
Objective The aim of this study was to construct an in vivo carotid siphon model for testing neurovascular devices for endovascular interventions. Methods A model of a human carotid siphon was pre-shaped using a glass tube from a human cadaver and used to confine a segment of one side of the common carotid artery (CCA) in canines. This segment of CCA with the glass carotid siphon on was interposed end-to-end onto the contralateral CCA so as to simulate a human carotid artery siphon in vivo. Two weeks later, the siphon model was evaluated using computed tomography angiography and digital subtraction angiography, and the covered stent specially designed for intracranial vasculature was navigated through the siphon model for a longitudinal flexibility test...
January 1, 2017: Interventional Neuroradiology
Irene Vuu, Lisa D Coles, Patricia Maglalang, Ilo E Leppik, Greg Worrell, Daniel Crepeau, Usha Mishra, James C Cloyd, Edward E Patterson
RATIONALE: Barriers to developing treatments for human status epilepticus include the inadequacy of experimental animal models. In contrast, naturally occurring canine epilepsy is similar to the human condition and can serve as a platform to translate research from rodents to humans. The objectives of this study were to characterize the pharmacokinetics of an intravenous (IV) dose of topiramate (TPM) in dogs with epilepsy and evaluate its effect on intracranial electroencephalographic (iEEG) features...
2016: Frontiers in Veterinary Science
Hoameng Ung, Kathryn A Davis, Drausin Wulsin, Joost Wagenaar, Emily Fox, John J McDonnell, Ned Patterson, Charles H Vite, Gregory Worrell, Brian Litt
OBJECTIVE: Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic intracranial recordings in canine epilepsy. METHODS: Continuous, yearlong intracranial electroencephalography (iEEG) recordings from four dogs with naturally occurring epilepsy were analyzed for seizures and interictal bursts...
December 2016: Epilepsia
Paolo Cariati, Almudena Cabello-Serrano, Fernando Monsalve-Iglesias, Maria Roman-Ramos, Blas Garcia-Medina
Complication of dental infections might be various and heterogeneous. The most common complications are represented by maxilar celulitis, canine space celulitis, infratemporal space celulitis, temporal celulitis and bacteremia. Among rarest complications we found: sepsis, bacterial endocarditis, mediastinitis, intracranial complications, osteomyelitis, etc. Although dental infections are often considered trivial entities, sometimes they can reach an impressive gravity. In this regard, the present study describes a case of dental infection complicated by meningitis, subdural empiema and cerebral vasculitis...
October 2016: Journal of Clinical and Experimental Dentistry
Orr Rozov, Pablo E Piñeyro, Kurt L Zimmerman, Ian P Herring, Rachel Matusow, John H Rossmeisl, Bernard S Jortner, Jennifer Dreyfus
Intracranial astrocytomas are relatively uncommon in dogs and optic nerve astrocytomas even more so. This neoplasm should be considered as differential in canine patients with vision loss, retinal detachment, ocular mass, and histopathologic findings of infiltrative fusiform to polygonal glial cells possibly associated with glomeruloid vascular proliferation.
September 2016: Clinical Case Reports
C Rohrer Bley, V Meier, P Schwarz, M Roos, J Besserer
Technical advances make it possible to deliver radiation therapy for canine intracranial tumours in fewer fractions, under the assumption of equivalent tumour control. With the aim of estimating the late toxicity risk profile for various tumour sizes and locations, the present paper evaluates the normal tissue complication probability (NTCP) values for the intracranial organs at risk. By making isoeffect calculations, a new 10-fraction radiation protocol was developed with the same tumour control probability (TCP) as a currently used 20-fraction standard protocol, and complication risk profiles for brain, brainstem and optic chiasm were modelled using a representative population of 64 dogs with brain tumours...
August 31, 2016: Veterinary and Comparative Oncology
Yogatheesan Varatharajah, Ravishankar K Iyer, Brent M Berry, Gregory A Worrell, Benjamin H Brinkmann
The ability to predict seizures may enable patients with epilepsy to better manage their medications and activities, potentially reducing side effects and improving quality of life. Forecasting epileptic seizures remains a challenging problem, but machine learning methods using intracranial electroencephalographic (iEEG) measures have shown promise. A machine-learning-based pipeline was developed to process iEEG recordings and generate seizure warnings. Results support the ability to forecast seizures at rates greater than a Poisson random predictor for all feature sets and machine learning algorithms tested...
February 2017: International Journal of Neural Systems
Mark G Luciano, Stephen M Dombrowski, Sara Qvarlander, Serge El-Khoury, Jun Yang, Suraj Thyagaraj, Francis Loth
OBJECT Intracranial pressure (ICP) pulsations are generally considered a passive result of the pulsatility of blood flow. Active experimental modification of ICP pulsations would allow investigation of potential active effects on blood and CSF flow and potentially create a new platform for the treatment of acute and chronic low blood flow states as well as a method of CSF substance clearance and delivery. This study presents a novel method and device for altering the ICP waveform via cardiac-gated volume changes...
July 15, 2016: Journal of Neurosurgery
Mi Zhou, Yongming Zeng, Renqiang Yu, Yang Zhou, Rui Xu, Jingkun Sun, Zhimei Gao
This study aims to evaluate the ability of C-arm cone-beam CT to detect intracranial hematomas in canine models. Twenty one healthy canines were divided into seven groups and each group had three animals. Autologous blood and contrast agent (3 mL) were slowly injected into the left/right frontal lobes of each animal. Canines in the first group, the control group, were only injected with autologous blood without contrast agent. Each animal in all the 7 groups was scanned with C-arm cone-beam CT and multislice computed tomography (MSCT) after 5 minutes...
February 2016: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
Benjamin H Brinkmann, Edward E Patterson, Charles Vite, Vincent M Vasoli, Daniel Crepeau, Matt Stead, J Jeffry Howbert, Vladimir Cherkassky, Joost B Wagenaar, Brian Litt, Gregory A Worrell
[This corrects the article DOI: 10.1371/journal.pone.0133900.].
2016: PloS One
A L Zwingenberger, R E Pollard, S L Taylor, R X Chen, J Nunley, M S Kent
BACKGROUND: Stereotactic radiosurgery (SRS) and stereotactic radiotherapy (SRT) are highly conformal, high-dose radiation treatment techniques used to treat people and dogs with brain tumors. OBJECTIVES: To evaluate the response to SRS- and SRT-treated tumors using volume and perfusion variables and to measure the survival times of affected dogs. ANIMALS: Prospective study of 34 dogs with evidence of brain tumors undergoing stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT)...
May 2016: Journal of Veterinary Internal Medicine
Helen Dirrig, Christopher R Lamb
Ante mortem diagnosis of canine meningoencephalitis is usually based on the results of neurologic examination, cerebrospinal fluid analysis and magnetic resonance (MR) imaging. It has been hypothesized that subtraction MR imaging may increase the sensitivity of MR for intracranial inflammatory lesions compared to conventional post-gadolinium T1-weighted imaging. Sensitivity of pre- and post-gadolinium (C-/C+) image pairs and dynamic subtraction (DS) images was compared in a retrospective diagnostic accuracy study of 52 dogs with inflammatory cerebrospinal fluid and 67 dogs with idiopathic epilepsy...
July 2016: Veterinary Radiology & Ultrasound
Benjamin H Brinkmann, Joost Wagenaar, Drew Abbot, Phillip Adkins, Simone C Bosshard, Min Chen, Quang M Tieng, Jialune He, F J Muñoz-Almaraz, Paloma Botella-Rocamora, Juan Pardo, Francisco Zamora-Martinez, Michael Hills, Wei Wu, Iryna Korshunova, Will Cukierski, Charles Vite, Edward E Patterson, Brian Litt, Gregory A Worrell
SEE MORMANN AND ANDRZEJAK DOI101093/BRAIN/AWW091 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE  : Accurate forecasting of epileptic seizures has the potential to transform clinical epilepsy care. However, progress toward reliable seizure forecasting has been hampered by lack of open access to long duration recordings with an adequate number of seizures for investigators to rigorously compare algorithms and results. A seizure forecasting competition was conducted on using open access chronic ambulatory intracranial electroencephalography from five canines with naturally occurring epilepsy and two humans undergoing prolonged wide bandwidth intracranial electroencephalographic monitoring...
June 2016: Brain: a Journal of Neurology
Fernando Campos Gomes Pinto, Rodrigo Becco, Eduardo Joaquim Lopes Alho, Luiz Francisco Poli-de-Figueiredo, Podalyro Amaral de Souza, Matheus Fernandes de Oliveira, Manoel Jacobsen Teixeira
Currently, hydrocephalus treatment is performed mainly with ventriculoperitoneal shunting. This experimental study aims at assessing whether the experimental model of hydrocephalus in dogs is applicable to the laboratory study of the retrograde ventriculosinusal shunt (RVSS). Four mongrel dogs were assessed. After randomization, the animals were divided into two groups: an experimental group that underwent the induction of hydrocephalus/RVSS and a control group, for the measurement of the mean arterial pressure, intracranial pressure and pressure in the superior sagittal sinus (SSS)...
2016: Pediatric Neurosurgery
G Bertolini, M Ricciardi, M Caldin
Focal fluid accumulations in the supracollicular region are commonly termed quadrigeminal cysts and may be either subclinical or associated with neurologic deficits in dogs. Little published information is available on normal imaging anatomy and anatomic relationships for the canine quadrigeminal cistern. Objectives of this observational, cross-sectional study were to describe normal quadrigeminal cistern anatomy and determine the prevalence and characteristics of supracollicular fluid accumulations in dogs...
May 2016: Veterinary Radiology & Ultrasound
Robert Fahed, Jean Raymond, Célina Ducroux, Jean-Christophe Gentric, Igor Salazkin, Daniela Ziegler, Guylaine Gevry, Tim E Darsaut
INTRODUCTION: Flow diversion (FD) is increasingly used to treat intracranial aneurysms. We sought to systematically review published studies to assess the quality of reporting and summarize the results of FD in various animal models. METHODS: Databases were searched to retrieve all animal studies on FD from 2000 to 2015. Extracted data included species and aneurysm models, aneurysm and neck dimensions, type of flow diverter, occlusion rates, and complications. Articles were evaluated using a checklist derived from the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines...
April 2016: Neuroradiology
Atigan Thongtharb, Kazuyuki Uchida, James Kenn Chambers, Yumiko Kagawa, Hiroyuki Nakayama
Histiocytic sarcoma is a progressive and fatal malignant neoplasm that mainly occurs in middle- to old-aged dogs. This study describes clinicopathological, histological and immunohistochemical characteristics of intracranial histiocytic sarcomas in 23 dogs. Magnetic resonance imaging and/or computed tomography of the brains revealed that the tumors mainly located in the cerebrum, particularly the frontal lobe. Seizure was a predominant clinical sign in most of the cases. Histologically, the tumor cells were morphologically classified into round/polygonal- and spindle-shaped cell types...
May 3, 2016: Journal of Veterinary Medical Science
John Henry Rossmeisl, Rudy T Andriani, Thomas E Cecere, Kevin Lahmers, Tanya LeRoith, Kurt L Zimmerman, Denise Gibo, Waldemar Debinski
This report describes the methodology, diagnostic yield, and adverse events (AE) associated with frame-based stereotactic brain biopsies (FBSB) obtained from 26 dogs with solitary forebrain lesions. Medical records were reviewed from dogs that underwent FBSB using two stereotactic headframes designed for use in small animals and compatible with computed tomographic (CT) and magnetic resonance (MR) imaging. Stereotactic plans were generated from MR and CT images using commercial software, and FBSB performed both with (14/26) and without intraoperative image guidance...
2015: Frontiers in Veterinary Science
Kathryn A Davis, Hoameng Ung, Drausin Wulsin, Joost Wagenaar, Emily Fox, Ned Patterson, Charles Vite, Gregory Worrell, Brian Litt
OBJECTIVE: Brain regions are localized for resection during epilepsy surgery based on rare seizures observed during a short period of intracranial electroencephalography (iEEG) monitoring. Interictal epileptiform bursts, which are more prevalent than seizures, may provide complementary information to aid in epilepsy evaluation. In this study, we leverage a long-term iEEG dataset from canines with naturally occurring epilepsy to investigate interictal bursts and their electrographic relationship to seizures...
January 2016: Epilepsia
Shruthi Vaidhyanathan, Brynna Wilken-Resman, Daniel J Ma, Karen E Parrish, Rajendar K Mittapalli, Brett L Carlson, Jann N Sarkaria, William F Elmquist
Small molecule inhibitors targeting the mitogen-activated protein kinase pathway (Braf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase) have had success in extending survival for patients with metastatic melanoma. Unfortunately, resistance may occur via cross-activation of alternate signaling pathways. One approach to overcome resistance is to simultaneously target the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. Recent reports have shown that GSK2126458 [2,4-difluoro-N-(2-methoxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl) benzenesulfonamide], a dual phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor, can overcome acquired resistance to Braf and mitogen-activated protein kinase kinase inhibitors in vitro...
February 2016: Journal of Pharmacology and Experimental Therapeutics
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