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https://www.readbyqxmd.com/read/29350351/convection-enhanced-delivery-of-cetuximab-conjugated-iron-oxide-nanoparticles-for-treatment-of-spontaneous-canine-intracranial-gliomas
#1
A Courtenay Freeman, Simon R Platt, Shannon Holmes, M Kent, Kelsey Robinson, Elizabeth Howerth, Joe Eagleson, Alexandros Bouras, Milota Kaluzova, Constantinos G Hadjipanayis
Cetuximab conjugated iron-oxide nanoparticles (cetuximab-IONPs) have shown both in-vitro and in-vivo anti-tumor efficacy against gliomas. The purpose of this pilot study was to evaluate the safety and potential efficacy of cetuximab-IONPs for treatment of spontaneously occurring intracranial gliomas in canines after convection-enhanced delivery (CED). The use of CED allowed for direct infusion of the cetuximab-IONPs both intratumorally and peritumorally avoiding the blood brain barrier (BBB) and limiting systemic effects...
January 19, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29307127/a-case-of-canine-neurological-leishmaniasis
#2
Rosanna Zobba, Maria Antonietta Evangelisti, Maria Lucia Manunta, Alberto Alberti
In this study we describe a case of neurological leishmaniasis in a dog, reported in an endemic area, with signs of multifocal intracranial lesions involving the vestibular system and the cerebellum. Serum biochemistry revealed a decrease of albumin-globulin ratio caused by an increase of alfa2-, beta-, and gamma- globulin, while antibody titers were highly positive for Leishmania spp. Magnetic resonance images of the brain were consistent with a granulomatous in ammation/infection. Cerebrospinal uid revealed a marked mononuclear pleocytosis and was positive to the Pandy Test, as well as to a Leishmania spp...
December 29, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29285579/r132-mutations-in-canine-isocitrate-dehydrogenase-1-idh1-lead-to-functional-changes
#3
Shota Kawakami, Kazuhiko Ochiai, Daigo Azakami, Yuiko Kato, Masaki Michishita, Masami Morimatsu, Toshina Ishiguro-Oonuma, Eri Onozawa, Masami Watanabe, Toshinori Omi
Glioma is the second most common intracranial neoplasia in dogs, but the pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 1 (IDH1) is frequently mutated in gliomas. Although almost all human IDH1 mutations have been identified as involving the Arg132 codon, few studies have reported structural, functional, and mutational information for canine IDH1. Therefore, in this study, we cloned the canine IDH1 homologue and used PCR mutagenesis to substitute the wildtype (WT) Arg132 with His (R132H) or Ser (R132S)...
December 29, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/29223000/bilateral-preictal-signature-of-phase-amplitude-coupling-in-canine-epilepsy
#4
Laura Gagliano, Elie Bou Assi, Dang K Nguyen, Sandy Rihana, Mohamad Sawan
Seizure forecasting would improve the quality of life of patients with refractory epilepsy. Although early findings were optimistic, no single feature has been found capable of individually characterizing brain dynamics during transition to seizure. Cross-frequency phase amplitude coupling has been recently proposed as a precursor of seizure activity. This work evaluates the existence of a statistically significant difference in mean phase amplitude coupling distribution between the preictal and interictal states of seizures in dogs with bilaterally implanted intracranial electrodes...
November 26, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29205634/safety-and-feasibility-of-stereotactic-radiotherapy-using-computed-portal-radiography-for-canine-intracranial-tumors
#5
Nicholas J Rancilio, R Timothy Bentley, Jeannie Poulson Plantenga, Magdalena M Parys, Beatriz G Crespo, George E Moore
Stereotactic radiotherapy is a highly conformal treatment option for intracranial and extracranial malignancies. Stereotactic radiotherapy utilizes specialized equipment specifically designed to avoid normal tissue while delivering ablative treatments with submillimeter precision and accuracy. Linear accelerator based stereotactic radiotherapy incorporates on-board image guidance utilizing cone beam computed tomography (CT). Many institutions lack the ability to provide image guidance with cone beam CT but delivery of highly conformal treatments with submillimeter precision and accuracy is still feasible...
December 4, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29171933/transpalpebral-ultrasonographic-measurement-of-the-optic-nerve-sheath-diameter-in-healthy-dogs
#6
Joshua J Smith, Daniel J Fletcher, Stacy D Cooley, Margret S Thompson
OBJECTIVE: To develop a reference range for ultrasonographically measured optic nerve sheath diameter (ONSD-US) in dogs. We hypothesized that ONSD-US can be measured reliably and is associated with weight but not age, sex, or body condition score (BCS), and that the relationship between weight and ONSD-US in dogs is allometric due to canine size variations. DESIGN: Prospective, observational study. SETTING: University teaching hospital. ANIMALS: Seventy-eight healthy adult dogs...
January 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29162772/functional-alteration-of-canine-isocitrate-dehydrogenase-2-idh2-via-an-r174k-mutation
#7
Shota Kawakami, Kazuhiko Ochiai, Yuiko Kato, Masaki Michishita, Hinako Hirama, Ryo Obara, Daigo Azakami, Masami Watanabe, Toshinori Omi
Gliomas are common intracranial neoplasias in dogs. However, the underlying pathogenic mechanisms remain unclear. In humans, isocitrate dehydrogenase 2 (IDH2) is often mutated in gliomas. Although almost human IDH2 mutations have been identified at the Arg172 codon, few studies have reported structural, functional, or mutational information for canine IDH2. In this study, we cloned the full-length canine IDH2 (cIDH2) cDNA and substituted wild type Arg174 (cIDH2 WT: corresponding to R172 of human IDH2) with Lys (cIDH2 R174K)...
November 21, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29073243/rna-seq-transcriptome-analysis-of-formalin-fixed-paraffin-embedded-canine-meningioma
#8
Jennifer K Grenier, Polly A Foureman, Erica A Sloma, Andrew D Miller
Meningiomas are the most commonly reported primary intracranial tumor in dogs and humans and between the two species there are similarities in histology and biologic behavior. Due to these similarities, dogs have been proposed as models for meningioma pathobiology. However, little is known about specific pathways and individual genes that are involved in the development and progression of canine meningioma. In addition, studies are lacking that utilize RNAseq to characterize gene expression in clinical cases of canine meningioma...
2017: PloS One
https://www.readbyqxmd.com/read/28993810/computed-tomography-and-magnetic-resonance-imaging-are-equivalent-in-mensuration-and-similarly-inaccurate-in-grade-and-type-predictability-of-canine-intracranial-gliomas
#9
Krystina L Stadler, Jeffrey D Ruth, Theresa E Pancotto, Stephen R Werre, John H Rossmeisl
While magnetic resonance imaging (MRI) is the gold-standard imaging modality for diagnosis of intracranial neoplasia, computed tomography (CT) remains commonly used for diagnosis and therapeutic planning in veterinary medicine. Despite the routine use of both imaging modalities, comparison of CT and MRI has not been described in the canine patient. A retrospective study was performed to evaluate CT and MRI studies of 15 dogs with histologically confirmed glioma. Multiple lesion measurements were obtained, including two-dimensional and volumetric dimensions in pre-contrast and post-contrast images...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28945061/a-comparative-study-of-cfd-of-canine-model-of-common-carotid-fusiform-aneurysm-and-vertebrobasilar-fusiform-aneurysm-in-human-patients
#10
Shewei Guo, Peng Jiang, Jian Liu, Xinjian Yang, Chuhan Jiang, Youxiang Li, Zhongxue Wu
BACKGROUND: Intracranial fusiform aneurysm (IFA) is a relatively uncommon subgroup of aneurysms. There are few reports that focus on the hemodynamics of IFA. In this study, we compared the hemodynamics of the canine model of common carotid fusiform aneurysm and vertebrobasilar fusiform aneurysms in human patients. METHODS: Five male mongrel dogs were randomly chosen, and there unilateral common carotid artery (CCA) and external jugular vein were surgically exposed individually...
September 22, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28920893/a-functional-genetic-scheme-for-seizure-forecasting-in-canine-epilepsy
#11
E Bou Assi, D K Nguyen, S Rihana, M Sawan
OBJECTIVE: The objective of this work is the development of an accurate seizure forecasting algorithm that considers brain's functional connectivity for electrode selection. METHODS: We start by proposing Kmeans-directed transfer function, an adaptive functional connectivity method intended for seizure onset zone localization in bilateral intracranial EEG recordings. Electrodes identified as seizure activity sources and sinks are then used to implement a seizure-forecasting algorithm on long-term continuous recordings in dogs with naturallyoccurring epilepsy...
September 13, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28879893/a-novel-swine-model-of-subarachnoid-hemorrhage-induced-cerebral-vasospasm
#12
Zion Zibly, Lory Fein, Mayur Sharma, Yaron Assaf, Anton Wohl, Sagi Harnof
OBJECTIVE: One of the most serious complications following subarachnoid hemorrhage (SAH) is delayed cerebral ischemia (DCI) secondary to symptomatic vasospasm. An animal model mimicking post SAH vasospasm is essential for enabling the translation of newer technologies from the conceptual phase to animal studies, and eventually to clinical trials. Various animal models of DCI following SAH have been reported, with canine models being the most common. Due to the similarity of the swine cardiovascular system and its dimensions to the human's system, the main objective of this study was to establish a consistent and quantitatively representative model of SAH-induced vasospasm in swine...
September 2017: Neurology India
https://www.readbyqxmd.com/read/28758278/clinical-and-imaging-findings-treatments-and-outcomes-in-27-dogs-with-imaging-diagnosed-trigeminal-nerve-sheath-tumors-a-multi-center-study
#13
Katie E Swift, Stephanie McGrath, Michael W Nolan, Martin Young, Michael Reese, Sangeeta Rao, Elissa Randall, Del Leary, Susan LaRue
The clinical behavior of canine trigeminal nerve sheath tumors and benefits of previously reported treatments are incompletely defined. Aims of this retrospective, multicenter, observational study were to describe clinical signs, tumor localization characteristics, treatments, and clinical outcomes in a group of dogs with this neoplasm. Databases at four hospitals were reviewed for dogs with a trigeminal nerve sheath tumor diagnosis, magnetic resonance imaging (MRI) studies, and presentation between 2004 and 2014...
July 31, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28741887/linac-based-stereotactic-radiation-therapy-for-canine-non-lymphomatous-nasal-tumours-29-cases-2013-2016
#14
T L Gieger, M W Nolan
Twenty-nine dogs were treated with linac-based stereotactic radiation therapy (SRT) for non-lymphomatous nasal tumours. Only dogs with a follow-up time >365 days were included in this retrospective analysis. No dogs had evidence of distant metastasis at diagnosis. Treatment was planned and a total of 30 Gy in 3 daily 10 Gy fractions was delivered using intensity-modulation, cone-beam CT-based image guidance and a robotic treatment couch. Clinical signs improved in all cases. Nineteen dogs had CT scans 3-4 months post-SRT and all had partial or complete tumour response...
July 25, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28713638/neurovascular-cell-sheet-transplantation-in-a-canine-model-of-intracranial-hemorrhage
#15
Woo-Jin Lee, Jong Young Lee, Keun-Hwa Jung, Soon-Tae Lee, Hyo Yeol Kim, Dong-Kyu Park, Jung-Suk Yu, So-Yun Kim, Daejong Jeon, Manho Kim, Sang Kun Lee, Jae-Kyu Roh, Kon Chu
Cell-based therapy for intracerebral hemorrhage (ICH) has a great therapeutic potential. However, methods to effectively induce direct regeneration of the damaged neural tissue after cell transplantation have not been established, which, if done, would improve the efficacy of cell-based therapy. In this study, we aimed to develop a cell sheet with neurovasculogenic potential and evaluate its usefulness in a canine ICH model. We designed a composite cell sheet made of neural progenitors derived from human olfactory neuroepithelium and vascular progenitors from human adipose tissue-derived stromal cells...
2017: Cell Medicine
https://www.readbyqxmd.com/read/28459961/crowdsourcing-seizure-detection-algorithm-development-and-validation-on-human-implanted-device-recordings
#16
Steven N Baldassano, Benjamin H Brinkmann, Hoameng Ung, Tyler Blevins, Erin C Conrad, Kent Leyde, Mark J Cook, Ankit N Khambhati, Joost B Wagenaar, Gregory A Worrell, Brian Litt
There exist significant clinical and basic research needs for accurate, automated seizure detection algorithms. These algorithms have translational potential in responsive neurostimulation devices and in automatic parsing of continuous intracranial electroencephalography data. An important barrier to developing accurate, validated algorithms for seizure detection is limited access to high-quality, expertly annotated seizure data from prolonged recordings. To overcome this, we hosted a kaggle.com competition to crowdsource the development of seizure detection algorithms using intracranial electroencephalography from canines and humans with epilepsy...
June 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28419635/canine-histiocytic-sarcoma-presenting-as-a-target-lesion-on-brain-magnetic-resonance-imaging-and-as-a-solitary-pulmonary-mass
#17
Jill Hicks, Renee Barber, Bronwen Childs, Shannon Gm Kirejczyk, Elizabeth W Uhl
A 6-year-old spayed female miniature schnauzer presented with generalized seizures and progressive multifocal intracranial neurologic disease. Thoracic radiographs and computed tomography (CT) revealed a large solitary pulmonary mass within the right cranial lung lobe. On brain magnetic resonance imaging (MRI), a solitary intraparenchymal mass within the left piriform lobe had a "target" appearance on both pre- and postcontrast sequences. Cerebrospinal fluid was unremarkable and histopathology indicated both masses represented histiocytic sarcoma...
April 17, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28410675/the-relationship-between-epileptiform-discharges-and-background-activity-in-the-visual-analysis-of-electroencephalographic-examinations-in-dogs-with-seizures-of-different-etiologies
#18
M Wrzosek, J R Ives, M Karczewski, E Dziadkowiak, E Gruszka
Electroencephalographic (EEG) recordings in 125 outpatient dogs with various epileptiform encephalopathies were acquired under medetomidine sedation using subdermal wire electrodes. The features of canine EEG (background activity [BGA] and epileptiform discharges [EDs]) were assessed, described and compared. The dogs included neurologically healthy controls (N, n = 19), dogs with portosystemic shunt (PSS, n = 9), dogs with intracranial pathologies (IP, n = 27) and dogs with idiopathic epilepsy (IE, n = 70)...
April 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28377923/dynamic-susceptibility-contrast-magnetic-resonance-imaging-protocol-of-the-normal-canine-brain
#19
Krystina L Stadler, Anthony P Pease, Elizabeth A Ballegeer
Perfusion magnetic resonance imaging (MRI), specifically dynamic susceptibility MRI (DSC-MRI) is routinely performed as a supplement to conventional MRI in human medicine for patients with intracranial neoplasia and cerebrovascular events. There is minimal data on the use of DSC-MRI in veterinary patients and a DSC-MRI protocol in the veterinary patient has not been described. Sixteen normal dogs, 6 years or older were recruited for this study. The sample population included 11 large dogs (>11 kg) and 5 small dogs (<11 kg)...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28357072/analysis-of-plasma-free-amino-acid-profiles-in-canine-brain-tumors
#20
Shinichi Utsugi, Kazuo Azuma, Tomohiro Osaki, Yusuke Murahata, Takeshi Tsuka, Norihiko Ito, Tomohiro Imagawa, Yoshiharu Okamoto
Canine brain tumors are best diagnosed using magnetic resonance imaging (MRI). However, opportunities of MRI examination are restricted due to its limited availability in veterinary facilities; thus, numerous canine brain tumors are diagnosed at an advanced stage. Therefore, development of a noninvasive diagnostic biomarker is required for the early detection of brain tumors. In the present study, plasma free amino acid (PFAA) profiles between dogs with and without brain tumors were compared. A total of 12 dogs with brain tumors, diagnosed based on clinical signs, and on the results of intracranial MRI and/or pathological examination were evaluated...
February 2017: Biomedical Reports
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