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https://www.readbyqxmd.com/read/29773092/preliminary-study-on-drug-susceptibility-profile-and-resistance-mechanisms-to-macrolides-of-clinical-isolates-of-non-tuberculous-mycobacteria-from-china
#1
Fu Li, Gui Lian Li, Hui Pang, Hai Can Liu, Tong Yang Xiao, Shuang Jun Li, Qiao Luo, Yi Jiang, Rui Bai Wang, Kang Lin Wan
OBJECTIVE: Macrolide susceptibility and drug resistance mechanisms of clinical non-tuberculous mycobacteria (NTM) isolates were preliminarily investigated for more accurate diagnosis and treatment of the infection in China. METHODS: Four macrolides, including clarithromycin (CLAR), azithromycin (AZM), roxithromycin (ROX), and erythromycin (ERY), were used to test the drug susceptibility of 310 clinical NTM isolates from six provinces of China with the broth microdilution method...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29764841/genetic-targeting-of-organ-specific-blood-vessels
#2
Wenjuan Pu, Lingjuan He, Ximeng Han, Xueying Tian, Yan Li, Hui Zhang, Qiaozhen Liu, Xiuzhen Huang, Libo Zhang, Qing-Dong Wang, Zhenyang Yu, Xiao Yang, Nicola Smart, Bin Zhou
<u>Rationale:</u> Organs of the body require vascular networks to supply oxygen and nutrients and maintain physiological function. The blood vessels of different organs are structurally and functionally heterogeneous in nature. To more precisely dissect their distinct in vivo function in individual organs, without potential interference from off-site targets, it is necessary to genetically target them in an organ-specific manner. <u>Objective:</u> To generate a genetic system that targets vascular endothelial cells in an organ- or tissue- specific manner and to exemplify the potential application of intersectional genetics for precise, target-specific gene manipulation in vivo...
May 15, 2018: Circulation Research
https://www.readbyqxmd.com/read/29759204/internal-standard-based-sers-aptasensor-for-ultrasensitive-quantitative-detection-of-ag-ion
#3
Yan Wu, Tingting Jiang, Zhaoyang Wu, Ruqin Yu
A ratiometric surface-enhanced Raman scattering (SERS) aptasensor based on internal standard (IS) methods was proposed for the ultrasensitive and reproducible quantitative detection of silver ion (Ag+ ) with Au@Ag core-shell nanoparticle (Au@Ag NP) substrate. In principle, the thiolated 5'-Rox C-containing labeled aptamer probe (Rox-aptamer) is firstly immobilized on the SERS substrate surface and then hybridizes with the complementary DNA (cDNA) to form a rigid double-stranded DNA (dsDNA), in which the Rox Raman labels is used to produce the Raman signal...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29727844/exploring-ozone-pollution-in-chengdu-southwestern-china-a-case-study-from-radical-chemistry-to-o-3-voc-no-x-sensitivity
#4
Zhaofeng Tan, Keding Lu, Meiqing Jiang, Rong Su, Huabin Dong, Limin Zeng, Shaodong Xie, Qinwen Tan, Yuanhang Zhang
We present the in-situ measurements in Chengdu, a major city in south west of China, in September 2016. The concentrations of ozone and its precursor were measured at four sites. Although the campaign was conducted in early autumn, up to 100 ppbv (parts per billion by volume) daily maximum ozone was often observed at all sites. The observed ozone concentrations showed good agreement at all sites, which implied that ozone pollution is a regional issue in Chengdu. To better understand the ozone formation in Chengdu, an observation based model is used in this study to calculate the ROx radical concentrations (ROx  = OH + HO2  + RO2 ) and ozone production rate (P(O3 ))...
May 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29726099/visualizing-oxidative-cellular-stress-induced-by-nanoparticles-in-the-subcytotoxic-range-using-fluorescence-lifetime-imaging
#5
Jens Balke, Pierre Volz, Falko Neumann, Robert Brodwolf, Alexander Wolf, Hannah Pischon, Moritz Radbruch, Lars Mundhenk, Achim D Gruber, Nan Ma, Ulrike Alexiev
Nanoparticles hold a great promise in biomedical science. However, due to their unique physical and chemical properties they can lead to overproduction of intracellular reactive oxygen species (ROS). As an important mechanism of nanotoxicity, there is a great need for sensitive and high-throughput adaptable single-cell ROS detection methods. Here, fluorescence lifetime imaging microscopy (FLIM) is employed for single-cell ROS detection (FLIM-ROX) providing increased sensitivity and enabling high-throughput analysis in fixed and live cells...
May 4, 2018: Small
https://www.readbyqxmd.com/read/29701140/expression-of-plasma-hsa-mir122-in-hbv-related-hepatocellular-carcinoma-hcc-in-vietnamese-patients
#6
Nguyen Bao Quoc, Nguyen Doan Nguyen Phuong, Tang Kim Ngan, Nguyen Thi Minh Linh, Pham Hung Cuong, Nguyen Ngoc Bao Chau
BACKGROUND: Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death in the world and considered as one of the most susceptible cancers in humans. The microRNA molecule, hsa-miR122, considered as a potential biological marker linked with the injury of hepatocellular tissue, is the most common microRNA in human liver cancer. Understanding the expression profile of hsa-miR122 plays an important role in the diagnosis of HCC Objective: Identification and comparison of cut-off values of plasma hsa-miR122 expression were conducted in blood samples of healthy control, HBV infected and HBV-related HCC Vietnamese patients Method and result: Fifty-two blood samples of healthy control and HBV-related HCC cases, collected between 2015 and 2017 were obtained from Ho Chi Minh City Oncology Hospital, Vietnam...
April 27, 2018: MicroRNA
https://www.readbyqxmd.com/read/29675328/smartphone-confocal-microscopy-for-imaging-cellular-structures-in-human-skin-in-vivo
#7
Esther E Freeman, Aggrey Semeere, Hany Osman, Gary Peterson, Milind Rajadhyaksha, Salvador González, Jeffery N Martin, R Rox Anderson, Guillermo J Tearney, Dongkyun Kang
We report development of a low-cost smartphone confocal microscope and its first demonstration of in vivo human skin imaging. The smartphone confocal microscope uses a slit aperture and diffraction grating to conduct two-dimensional confocal imaging without using any beam scanning devices. Lateral and axial resolutions of the smartphone confocal microscope were measured as 2 and 5 µm, respectively. In vivo confocal images of human skin revealed characteristic cellular structures, including spinous and basal keratinocytes and papillary dermis...
April 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29594738/a-gold-nanoparticle-based-fluorescent-probe-for-simultaneous-recognition-of-single-stranded-dna-and-double-stranded-dna
#8
Haiyan Ma, Zongbing Li, Ning Xue, Zhiyuan Cheng, Xiangmin Miao
A fluorescent method is described for simultaneous recognition of single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). It is based on the quenching of the fluorescence of fluorophore labeled DNA probes by gold nanoparticles (AuNPs). To demonstrate feasibility, two DNA probes labeled with spectrally different fluorophores were designed. The first DNA probe (P1 ) was modified with 6-carboxyfluorescein (FAM; with green fluorescence, peaking at 518 nm), while the second (P2 ) was modified with carboxy-X-rhodamine (ROX; with yellow fluorescence, 610 nm)...
January 10, 2018: Mikrochimica Acta
https://www.readbyqxmd.com/read/29550713/select-antibiotics-in-leachate-from-closed-and-active-landfills-exceed-thresholds-for-antibiotic-resistance-development
#9
S S Chung, J S Zheng, S R Burket, B W Brooks
Though antibiotic resistance (ABR) represents a major global health threat, contributions of landfill leachate to the life cycle of antibiotics and ABR development are poorly understood in rapidly urbanizing regions of developing countries. We selected one of the largest active landfills in Asia and two landfills that have been closed for 20 years to examine antibiotic occurrences in leachates and associated hazards during wet and dry season sampling events. We focused on some of the most commonly used human antibiotics in Hong Kong, one of the most populous Asian cities and the fourth most densely populated cities in the world...
March 15, 2018: Environment International
https://www.readbyqxmd.com/read/29537286/switchable-triggered-interconversion-and-reconfiguration-of-dna-origami-dimers-and-their-use-for-programmed-catalysis
#10
Jianbang Wang, Zhixin Zhou, Liang Yue, Shan Wang, Itamar Willner
The switchable reconfiguration of a mixture of two dimers of DNA origami tiles AB and CD into a mixture of two DNA origami dimers composed of AD and CB, using collection of fuel and anti-fuel strands, is presented. The reversible reconfiguration of the mixture of dimers AB/CD into AD/CB followed by labeling each of the tile with 0, 1, 2 and 3 4× hairpins labels and by imaging the dimer structures by AFM. Subjecting the reconfigurable dimer mixtures to a collection of Mg2+ -dependent DNAzyme subunits and the substrates consisting of the ROX/BHQ2-modified substrate and the FAM/BHQ1-modified substrate leads to the triggered and programmed switchable operation in the presence of appropriate fuel and anti-fuel strands...
March 14, 2018: Nano Letters
https://www.readbyqxmd.com/read/29522147/evaluation-and-treatment-of-hirsutism-in-premenopausal-women-an-endocrine-society-clinical-practice-guideline
#11
Kathryn A Martin, R Rox Anderson, R Jeffrey Chang, David A Ehrmann, Rogerio A Lobo, M Hassan Murad, Michel M Pugeat, Robert L Rosenfield
Objective: To update the "Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline," published by the Endocrine Society in 2008. Participants: The participants include an Endocrine Society-appointed task force of seven medical experts and a methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation system to describe the strength of recommendations and the quality of evidence...
March 7, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29521461/wear-and-corrosion-interactions-at-the-titanium-zirconia-interface-dental-implant-application
#12
Craig L Sikora, Maria F Alfaro, Judy Chia-Chun Yuan, Valentim A Barao, Cortino Sukotjo, Mathew T Mathew
PURPOSE: Dental implants have been shown to have predictable success, but esthetic complications often arise. To reduce tissue shadowing from titanium, zirconia abutments may be used; however, the literature suggests that the use of zirconia leads to greater destruction of the implant interface that may result in biological complications such as titanium tattoos and heavy metal toxicity. Previous studies have examined the mechanical aspects of this implant/abutment relationship, but they have not accounted for the corrosive degradation that also takes place in the dynamic environment of the oral cavity...
March 9, 2018: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29513141/seasonal-distribution-characteristics-and-health-risk-assessment-of-typical-antibiotics-in-the-harbin-section-of-the-songhua-river-basin
#13
Weihua Wang, Wanfeng Zhang, Hong Liang, Dawen Gao
A method was established for coupled solid phase extraction-ultra performance liquid chromatography and mass spectrometry, to simultaneously detect 12 common antibiotics belonging to 4 types (sulfonamides, macrolides, fluoroquinolones and cephalosporins) in the Harbin section of the Songhua River basin, Northeastern China. The results showed that the 12 antibiotics monitored were all detected to varying degrees, with 100% detection rates for sulfamethoxazole (SMX), cefazolin (CFZ), ofloxacin (OFL), flumequine (FLU), azithromycin (AZI) and roxithromycin (ROX), and the highest levels were in winter, the lowest in summer...
March 14, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29477827/transfer-of-arsenic-from-poultry-feed-to-poultry-litter-a-mass-balance-study
#14
Sanjay K Gupta, X Chris Le, Gary Kachanosky, Martin J Zuidhof, Tariq Siddique
Roxarsone (rox), an arsenic (As) containing organic compound, is a common feed additive used in poultry production. To determine if As present in rox is excreted into the poultry litter without any retention in chicken meat for safe human consumption, the transference of As from the feed to poultry excreta was assessed using two commercial chicken strains fed with and without dietary rox. The results revealed that both the strains had similar behaviour in growth (chicken weight; 2.17-2.25kg), feed consumption (282-300kgpen-1 initially containing 102 chicken) and poultry litter production (73-81kgpen-1 ) during the growth phase of 35days...
July 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29458318/protocol-summary-and-statistical-analysis-plan-for-the-intensive-care-unit-randomised-trial-comparing-two-approaches-to-oxygen-therapy-icu-rox
#15
Diane M Mackle, Michael J Bailey, Richard W Beasley, Rinaldo Bellomo, Victoria L Bennett, Adam M Deane, Glenn M Eastwood, Simon Finfer, Ross C Freebairn, Edward Litton, Natalie J Linke, Colin J McArthur, Shay P McGuinness, Rakshit Panwar, Paul J Young
BACKGROUND: The balance of risks and benefits of conservative v standard care oxygen strategies for patients who are invasively ventilated in the intensive care unit (ICU) is uncertain. OBJECTIVE: To describe the study protocol and statistical analysis plan for the ICU randomised trial comparing two approaches to oxygen therapy (ICU-ROX). DESIGN, SETTING AND PARTICIPANTS: Protocol for a multicentre, randomised, participant and outcome assessor-blinded, standard care-controlled, parallel-group, two-sided superiority trial to be conducted in up to 22 ICUs in Australia and New Zealand...
March 2018: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
https://www.readbyqxmd.com/read/29454062/laser-assisted-delivery-of-synergistic-combination-chemotherapy-in-in-vivo-skin
#16
Emily Wenande, Joshua Tam, Brijesh Bhayana, Steven Kyle Schlosser, Emily Ishak, William A Farinelli, Agata Chlopik, Mai P Hoang, Omar R Pinkhasov, Peter Caravan, R Rox Anderson, Merete Haedersdal
The effectiveness of topical drugs for treatment of non-melanoma skin cancer is greatly reduced by insufficient penetration to deep skin layers. Ablative fractional lasers (AFLs) are known to enhance topical drug uptake by generating narrow microchannels through the skin, but information on AFL-drug delivery in in vivo conditions is limited. In this study, we examined pharmacokinetics, biodistribution and toxicity of two synergistic chemotherapy agents, cisplatin and 5-fluorouracil (5-FU), following AFL-assisted delivery alone or in combination in in vivo porcine skin...
April 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29438490/detection-of-novel-metabolite-for-roxadustat-doping-by-global-metabolomics
#17
Daisuke Saigusa, Norio Suzuki, Yotaro Matsumoto, Keiko Umeda, Yoshihisa Tomioka, Seizo Koshiba, Masayuki Yamamoto
Roxadustat (FG-4592, Rox) is a stabilizer for hypoxia-inducible transcription factors (HIFs), which induce production of the erythroid growth factor erythropoietin, and has been listed by the World Anti-Doping Agency as a prohibited substance for athletes since 2011. Although the detection technologies for Rox and its glucuronide-conjugated metabolite (Rox-Gluc) have been developed exploiting triple quadrupole mass spectrometry (MS/MS), the production of metabolites from Rox in the human body remains to be clarified...
February 9, 2018: Journal of Biochemistry
https://www.readbyqxmd.com/read/29436720/an-expanded-study-of-long-pulsed-1064-nm-nd-yag-laser-treatment-of-basal-cell-carcinoma
#18
Arisa E Ortiz, R Rox Anderson, Catherine DiGiorgio, Shang I Brian Jiang, Faiza Shafiq, Mathew M Avram
BACKGROUND AND OBJECTIVE: Basal cell carcinoma (BCC) is an indolent form of skin cancer that is rarely life threatening, but can cause significant cosmetic and functional morbidity. Surgical treatments often result in disfiguring scars, while topical therapies frequently result in recurrence. The need for a more effective nonsurgical alternative has led to the investigation of laser treatment of BCC. We have previously conducted a pilot study which showed 100% histologic clearance at high fluences...
February 13, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29398560/rox-a-rifamycin-resistance-enzyme-with-an-unprecedented-mechanism-of-action
#19
Kalinka Koteva, Georgina Cox, Jayne K Kelso, Matthew D Surette, Haley L Zubyk, Linda Ejim, Peter Stogios, Alexei Savchenko, Dan Sørensen, Gerard D Wright
Rifamycin monooxygenases (Rox) are present in a variety of environmental bacteria and are associated with decomposition of the clinically utilized antibiotic rifampin. Here we report the structure and function of a drug-inducible rox gene from Streptomyces venezuelae, which encodes a class A flavoprotein monooxygenase that inactivates a broad range of rifamycin antibiotics. Our findings describe a mechanism of rifamycin inactivation initiated by monooxygenation of the 2-position of the naphthyl group, which subsequently results in ring opening and linearization of the antibiotic...
April 19, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29394055/a-long-lived-triplet-state-is-the-entrance-gateway-to-oxidative-photochemistry-in-green-fluorescent-proteins
#20
Martin Byrdin, Chenxi Duan, Dominique Bourgeois, Klaus Brettel
Though ubiquitously used as selective fluorescence markers in cellular biology, fluorescent proteins (FPs) still have not disclosed all of their surprising properties. One important issue, notably for single-molecule applications, is the nature of the triplet state, suggested to be the starting point for many possible photochemical reactions leading to phenomena such as blinking or bleaching. Here, we applied transient absorption spectroscopy to characterize dark states in the prototypical enhanced green fluorescent protein (EGFP) of hydrozoan origin and, for comparison, in IrisFP, a representative phototransformable FP of anthozoan origin...
February 28, 2018: Journal of the American Chemical Society
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