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https://www.readbyqxmd.com/read/28924140/linoleic-and-palmitoleic-acid-block-streptokinase-mediated-plasminogen-activation-and-reduce-severity-of-invasive-group-a-streptococcal-infection
#1
Katharina Rox, Rolf Jansen, Torsten G Loof, Christine M Gillen, Steffen Bernecker, Mark J Walker, Gursharan Singh Chhatwal, Rolf Müller
In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria are capable to hide from them very quickly. Therefore, new remedies are urgently needed. Starting from a myxobacterial natural products screening campaign, we identified two fatty acids isolated from myxobacteria, linoleic and palmitoleic acid, specifically blocking streptokinase-mediated activation of plasminogen and thereby preventing streptococci from hijacking the host's plasminogen/plasmin system...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892855/oxidizing-capacity-of-the-rural-atmosphere-in-hong-kong-southern-china
#2
Zeyuan Li, Likun Xue, Xue Yang, Qiaozhi Zha, Yee Jun Tham, Chao Yan, Peter K K Louie, Connie W Y Luk, Tao Wang, Wenxing Wang
Atmospheric oxidizing capacity (AOC), dominated by the hydroxyl radical (OH), is an important index of the self-cleaning capacity of atmosphere and plays a vital role in the tropospheric chemistry. To better understand the key processes governing the chemistry of rural atmosphere of southern China, we analyzed the oxidation capacity and radical chemistry at a regional background site in Hong Kong from 23 August to 22 December 2012, which covered the summer, autumn and winter seasons. A chemical box model built on the latest Master Chemical Mechanism (v3...
September 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28882037/reusable-silicon-based-surface-enhanced-raman-scattering-ratiometric-aptasensor-with-high-sensitivity-specificity-and-reproducibility
#3
Huayi Shi, Na Chen, Yuanyuan Su, Houyu Wang, Yao He
Rapid, sensitive and accurate detection of adenosine triphosphate (ATP), the primary energy molecule, is critical for the elucidation of its unique roles in cell signaling and many cellular reactions. Up to date, major challenge is still remaining for fabricating surface-enhanced Raman scattering (SERS) aptamer sensors (aptasensors), suitable for accurate and reliable quantification of ATP. Herein, we develop the ratiometric silicon SERS aptasensor for ATP detection, which is made of uniform silver nanoparticles (Ag NPs)-modified silicon wafer (Ag NPs@Si), followed by the functionalization with double-stranded DNA (dsDNA I)...
September 8, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28851915/poisson-plus-quantification-for-digital-pcr-systems
#4
Nivedita Majumdar, Swapnonil Banerjee, Michael Pallas, Thomas Wessel, Patricia Hegerich
Digital PCR, a state-of-the-art nucleic acid quantification technique, works by spreading the target material across a large number of partitions. The average number of molecules per partition is estimated using Poisson statistics, and then converted into concentration by dividing by partition volume. In this standard approach, identical partition sizing is assumed. Violations of this assumption result in underestimation of target quantity, when using Poisson modeling, especially at higher concentrations. The Poisson-Plus Model accommodates for this underestimation, if statistics of the volume variation are well characterized...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28843197/novel-ratiometric-surface-enhanced-raman-spectroscopy-aptasensor-for-sensitive-and-reproducible-sensing-of-hg-2
#5
Yan Wu, Tingting Jiang, Zhaoyang Wu, Ruqin Yu
It is important to precisely monitor mercury (II) ions (Hg(2+)) for environment protection and human health monitoring. Although many strategies have been developed in the past decades, there still remains a challenge for developing an ultrasensitive, simple and reliable approach to detect Hg(2+). Herein, we report a ratiometric surface-enhanced Raman scattering (SERS) aptasensor by employing aptamer-modified Au@Ag core-shell nanoparticles (Au@Ag NPs) as highly functional sensing probes, allowing for ultrasensitive detection of Hg(2+)...
August 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28831103/a-novel-fluorescent-imaging-technique-for-assessment-of-cerebral-vasospasm-after-experimental-subarachnoid-hemorrhage
#6
Diane J Aum, Ananth K Vellimana, Itender Singh, Eric Milner, James W Nelson, Byung Hee Han, Gregory J Zipfel
Various techniques have been developed to study changes in the cerebral vasculature in numerous neuropathological processes including subarachnoid hemorrhage (SAH). One of the most widely employed techniques uses India ink-gelatin casting, which presents numerous challenges due to its high viscosity, rapid solidification, and its impact on immunohistochemical analysis. To overcome these limitations, we developed a novel technique for assessing cerebral vasospasm using cerebrovascular perfusion with ROX, SE (5-Carboxy-X-Rhodamine, Succinimidyl Ester), a fluorescent labeling dye...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28772338/qualification-of-a-select-one-stage-activated-partial-thromboplastin-time-based-clotting-assay-and-two-chromogenic-assays-for-the-post-administration-monitoring-of-nonacog-beta-pegol
#7
Stefan Tiefenbacher, Rahul Bohra, Jean Amiral, Annette Bowyer, Steve Kitchen, Anne Lochu, Steffen Rosén, Mirella Ezban
BACKGROUND: Nonacog beta pegol (N9-GP) is an extended half-life, glycoPEGylated recombinant human factor IX (FIX) under development for the prophylaxis and treatment of bleeding episodes in hemophilia B patients. Considerable reagent-dependent variability has been observed when one-stage clotting assays are used to measure the recovery of recombinant FIX products, including N9-GP. OBJECTIVE: To qualify select one-stage clotting and chromogenic FIX activity assays for measuring N9-GP recovery...
August 3, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28723201/imaging-lysosomal-ph-alteration-in-stressed-cells-with-a-sensitive-ratiometric-fluorescence-sensor
#8
Zhongwei Xue, Hu Zhao, Jian Liu, Jiahuai Han, Shoufa Han
The organelle-specific pH is crucial for cell homeostasis. Aberrant pH of lysosomes has been manifested in myriad diseases. To probe lysosome responses to cell stress, we herein report the detection of lysosomal pH changes with a dual colored probe (CM-ROX), featuring a coumarin domain with "always-on" blue fluorescence and a rhodamine-lactam domain activatable to lysosomal acidity to give red fluorescence. With sensitive ratiometric signals upon subtle pH changes, CM-ROX enables discernment of lysosomal pH changes in cells undergoing autophagy, cell death, and viral infection...
March 24, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28688255/natural-degradation-of-roxarsone-in-contrasting-soils-degradation-kinetics-and-transformation-products
#9
Qing-Long Fu, Lee Blaney, Dong-Mei Zhou
Roxarsone (ROX) is transformed to more toxic arsenicals after land application of ROX-containing poultry litter to agricultural soils. To date, no reports have compared ROX degradation in soils with contrasting properties. In this study, the impact of different incubation conditions on ROX degradation was investigated in red (C-Soil) and yellow-brown (H-Soil) soils. The degradation half-lives of extractable ROX in C-Soil and H-Soil were found to be 130-394d and 4-94d, respectively, indicating that the extractable ROX degraded faster in H-Soil...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28551741/soil-calcium-significantly-promotes-uptake-of-inorganic-arsenic-by-garland-chrysanthemum-chrysanthemuml-coronarium-fertilized-with-chicken-manure-bearing-roxarsone-and-its-metabolites
#10
Lixian Yao, Lianxi Huang, Cuihua Bai, Zhaohuan He, Changmin Zhou
Roxarsone (ROX), a widely used feed organoarsenic additive, occurs as itself and its metabolites in animal manure that is commonly land used as fertilizer. Soil property impacts arsenic (As) speciation and bioavailability. Fourteen soils across China were used to conduct culture experiments to investigate As uptake by garland chrysanthemum (ChrysanthemumL coronarium), with the soils fertilized with chicken manure bearing ROX and its metabolites. The results show As(III) was the sole As form in garland chrysanthemum shoots, and As(III) and As(V) occurred in roots...
July 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28542449/specific-expression-and-function-of-the-a-type-cytochrome-c-oxidase-under-starvation-conditions-in-pseudomonas-aeruginosa
#11
Tatsuya Osamura, Takuro Kawakami, Reiko Kido, Masaharu Ishii, Hiroyuki Arai
Pseudomonas aeruginosa has one A-type (caa3) and multiple C-type (cbb3) cytochrome c oxidases as well as two quinol oxidases for aerobic respiration. The caa3 oxidase is highly efficient in creating a proton gradient across the cell membrane, but it is not expressed under normal growth conditions and its physiological role has not been investigated. In the present study, a mutant strain deficient in the coxBA-PA0107-coxC genes encoding caa3 exhibited normal growth under any test conditions, but it had low relative fitness under carbon starvation conditions, indicating that the expression of caa3 is advantageous under starvation conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28539749/erratum-bioactivity-of-diterpens-from-the-ethyl-acetate-extract-of-kingiodendron-pinnatum-rox-hams
#12
(no author information available yet)
[This corrects the article on p. 287 in vol. 8, PMID: 27695270.].
April 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/28490439/skeletal-muscle-metabolism-during-prolonged-exercise-in-pompe-disease
#13
Nicolai Preisler, Pascal Laforêt, Karen Lindhardt Madsen, Edith Husu, Christoffer Rasmus Vissing, Gitte Hedermann, Henrik Galbo, Christopher Lindberg, John Vissing
OBJECTIVE: Pompe disease (glycogenosis type II) is caused by lysosomal alpha-glucosidase deficiency, which leads to a block in intra-lysosomal glycogen breakdown. In spite of enzyme replacement therapy, Pompe disease continues to be a progressive metabolic myopathy. Considering the health benefits of exercise, it is important in Pompe disease to acquire more information about muscle substrate use during exercise. METHODS: Seven adults with Pompe disease were matched to a healthy control group (1:1)...
August 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28490103/speciation-analysis-of-organoarsenic-compounds-in-livestock-feed-by-microwave-assisted-extraction-and-high-performance-liquid-chromatography-coupled-to-atomic-fluorescence-spectrometry
#14
A A Saucedo-Velez, L Hinojosa-Reyes, M Villanueva-Rodríguez, A Caballero-Quintero, A Hernández-Ramírez, J L Guzmán-Mar
The development of a new method to determine the presence of the organoarsenic additives p-arsanilic acid (ASA), roxarsone (ROX) and nitarsone (NIT) in livestock feeds by high performance liquid chromatography coupled to ultraviolet oxidation hydride generation atomic fluorescence spectrometry (HPLC-UV/HG-AFS) after microwave assisted extraction (MAE) was proposed. Chromatographic separation was achieved on a C18 column with 2% acetic acid/methanol (96:4, v/v) as the mobile phase. The limits of detection (LODs) were 0...
October 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28471088/the-use-of-a-novel-rox-central-arteriovenous-fistula-formation-device-in-a-patient-with-severe-drug-resistant-hypertension-and-prior-aortic-graft
#15
Mark Hensey, Elizabeth Smyth, Elaine Gilroy, Joseph Galvin
We report a case of the successful use of a central arteriovenous (cAV) coupler device to treat severe drug-resistant primary hypertension in a 46-year-old female. The device is inserted via a femoral approach to create an ateriovenous fistula between the external iliac artery and vein and has shown promise in the treatment of severe hypertension. The patient's 24-hr ambulatory blood pressure (ABP) pre device insertion on eleven anti-hypertensive medications revealed a mean 24-hr ABP of 165/98 mm Hg. The insertion of the cAV coupler resulted in a sustained anti-hypertensive effect nine months post-procedure, with mean 24-hr ABP of 154/91 mm Hg on only two anti-hypertensives...
July 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28470989/methylated-phenylarsenical-metabolites-discovered-in-chicken-liver
#16
Hanyong Peng, Bin Hu, Qingqing Liu, Jinhua Li, Xing-Fang Li, Hongquan Zhang, X Chris Le
We report the discovery of three toxicologically relevant methylated phenylarsenical metabolites in the liver of chickens fed 3-nitro-4-hydroxyphenylarsonic acid (ROX), a feed additive in poultry production that is still in use in several countries. Methyl-3-nitro-4-hydroxyphenylarsonic acid (methyl-ROX), methyl-3-amino-4-hydroxyphenylarsonic acid (methyl-3-AHPAA), and methyl-3-acetamido-4-hydroxyphenylarsonic acid (or methyl-N-acetyl-ROX, methyl-N-AHPAA) were identified in such chicken livers, and the concentration of methyl-ROX was as high as 90 μg kg(-1) , even after a five-day clearance period...
June 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28453965/adsorption-behavior-and-mechanism-of-different-arsenic-species-on-mesoporous-mnfe2o4-magnetic-nanoparticles
#17
Qingsong Hu, Yuling Liu, Xueyuan Gu, Yaping Zhao
Arsenic pollution poses severe threat to human health, therefore dealing with the problem of arsenic contamination in water bodies is extremely important. The adsorption behaviors of different arsenic species, such as arsenate (As(V)), p-arsanilic acid (p-ASA), roxarsone (ROX), dimethylarsenate (DMA) from water using mesoporous bimetal oxide magnetic manganese ferrite nanoparticles (MnFe2O4) have been detailedly investigated. The adsorbent was synthesized via a facile co-precipitation approach and recovered conveniently owing to its strong magnetic properties...
August 2017: Chemosphere
https://www.readbyqxmd.com/read/28436820/srna-mediated-activation-of-gene-expression-by-inhibition-of-5-3-exonucleolytic-mrna-degradation
#18
Sylvain Durand, Frédérique Braun, Anne-Catherine Helfer, Pascale Romby, Ciarán Condon
Post-transcriptional control by small regulatory RNA (sRNA) is critical for rapid adaptive processes. sRNAs can directly modulate mRNA degradation in Proteobacteria without interfering with translation. However, Firmicutes have a fundamentally different set of ribonucleases for mRNA degradation and whether sRNAs can regulate the activity of these enzymes is an open question. We show that Bacillus subtilis RoxS, a major trans-acting sRNA shared with Staphylococus aureus, prevents degradation of the yflS mRNA, encoding a malate transporter...
April 24, 2017: ELife
https://www.readbyqxmd.com/read/28405751/developmental-validation-of-a-6-dye-str-kit-with-27-loci
#19
Shuanglin Li, Ling Chen, Yanfang Wang, Quyi Xu, Hong Liu, Yue Li, Chao Liu
The EX27 System is a 6-dye (i.e., FAM, HEX, TAMAR, ROX, VIG, and SIZ-500) kit that combines the 24 autosomal STR loci (i.e., D3S1358, D13S317, D7S820, D16S539, D1S1656, Penta E, TPOX, TH01, D2S1338, CSF1PO, Penta D, D10S1248, D19S433, vWA, D21S11, D18S51, D6S1043, D8S1179, D5S818, D12S391, FGA, D22S1045, D2S441, SE33) with a Y-STR locus (DYS391), an Indel site (YIndel) and Amelogenin, which is designed to amplify DNA from extracts as well as direct amplification from substrates. The new system contains most of the widely used autosomal STR loci around the world and is sensitive to the male component in mixtures and is more accurate in gender determination owing to the DYS391 and YIndel...
April 12, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28382716/identical-presentation-of-scapular-osteolysis-in-two-patients-with-thoracic-kaposiform-hemangioendothelioma
#20
Verónica Alonso Arroyo, Juan Carlos Lopez-Gutierrez, Rox Martinez, Israel Fernandez-Pineda
Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that does not metastasize. We report two unique cases of KHE involving the right hemithorax and the upper ipsilateral extremity. Kasabach-Merrit phenomenon and osteolytic lesions in the scapula were observed in both cases.
April 6, 2017: Pediatric Dermatology
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