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https://www.readbyqxmd.com/read/29218000/synapse-specific-regulation-revealed-at-single-synapses-is-concealed-when-recording-multiple-synapses
#1
Justin Lines, Ana Covelo, Ricardo Gómez, Lan Liu, Alfonso Araque
Synaptic transmission and its activity-dependent modulation, known as synaptic plasticity, are fundamental processes in nervous system function. Neurons may receive thousands of synaptic contacts, but synaptic regulation may occur only at individual or discrete subsets of synapses, which may have important consequences on the spatial extension of the modulation of synaptic information. Moreover, while several electrophysiological methods are used to assess synaptic transmission at different levels of observation, i...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29217923/enhancing-personal-hygiene-behavior-and-competency-of-elementary-school-adolescents-through-peer-led-approach-and-school-friendly-a-quasi-experimental-study
#2
Dessalegn Tamiru, Alemayehu Argaw, Mulusew Gerbaba, Girmay Ayana, Aderajew Nigussie, Hunduma Jisha, Tefera Belachew
Background: Recent studies showed that poor personal hygiene practices play a major role in the increment of communicable disease burden in developing countries. In Ethiopia, 60% of the disease burden is related to poor sanitation practices. This school based study was aimed to assess the effectiveness of school-friendly and peer-led approach in improving personal hygiene practices of school adolescents in Jimma Zone, Southwest of Ethiopia. Methods: A total of 1000 students from 10 to 19 years were included into the study...
May 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29211212/comparative-study-of-electrical-stimulation-of-the-heart-with-vdd-and-ddd-pacemakers-as-to-the-evolution-to-atrial-fibrillation
#3
Nelson Leonardo Kerdahi Leite de Campos, Rubens Ramos de Andrade, Marcello Laneza Fellicio, Antônio Sergio Martins, André Monti Garzesi, Leonardo Rufino Garcia, Tassya Bueno Takeda
INTRODUCTION: The pacemaker implantation VDD is considered simpler, faster, less expensive and causes fewer complications compared to DDD. However, the VDD pacemaker has not been widely used in many centers, perhaps for fear of dysfunction of the sinus node and the reduction of atrial sensitivity by the pacemaker during follow-up after implantation. OBJECTIVE: To compare patients with DDD and VDD pacemakers regarding the evolution of chronic atrial fibrillation (AF) and length of stay outside this postoperative arrhythmia...
September 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29209685/-knowledge-attitude-and-behavior-towards-oral-health-gender-differences-between-parents
#4
F Guerra, F Rinaldo, A Mannocci, M Mazur, D Corridore, G Di Giorgio, A Polimeni, L Ottolenghi, G M Nardi
OBJECTIVES: The aim of this study is to compare the results of a survey carried out on a sample of mothers and fathers about the knowledge and personal attitudes towards their own oral health and in terms of attention to that of their children. Mutual analogy and cognitive and behavioral differences between parents have been evaluated; in particular as the early assumption of a healthy lifestyle can influence the proper development of their children. MATERIALS AND METHODS: This survey was conducted using a paper questionnaire distributed to a population of parents, men and women, in several private dental practices in Rome...
November 2017: La Clinica Terapeutica
https://www.readbyqxmd.com/read/29207839/evaluation-of-effect-of-irrigants-with-or-without-surfactant-on-root-canal-transportation-by-cone-beam-computed-tomography-an-in-vitro-study
#5
Siddiq Ahmed, Prabu Mahin Syed Ismail, M Chandra Sekhar, Sampathi Naga Lakshmi Reddy, Moosani Gopi Krishna, Upendra Natha Reddy, Kalla Nikhita, P Sai Harish
Introduction: Maintenance of original canal anatomy with proper disinfection is our primary goal to achieve during root canal instrumentation. Surfactants are added to irrigating solution to promote deeper penetration into dentinal tubules. Aim: The aim of this study was to evaluate the influence of addition of surfactants to Sodium Hypochlorite (NaOCl) and Ethylenediaminetetraacetic Acid (EDTA) on transportation of root canal. Materials and Methods: Fifty human mandibular molars with mesial root curvatures of 10° - 40° were selected and embedded in silicone impression material to simulate mandibular arch form to facilitate imaging process and maintain reproducibility of images...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29207713/analysis-of-patient-s-satisfaction-with-phlebotomy-services-in-nabh-accredited-neuropsychiatric-hospital-an-effective-tool-for-improvement
#6
Anshu Gupta, Tanima Dwivedi, Sadhana, Raju Chaudhary
Introduction: Patient's satisfaction is the need of the hour and one of the most important quality indicators in the laboratory medicine. Aim: To assess the patient's satisfaction with phlebotomy services in a neuropsychiatric hospital by a structured questionnaire with grading scale. Also, identify the problems causing dissatisfactions and to undertake necessary Corrective and Preventative Action (CAPA). Materials and Methods: Total 1200 patients were randomly selected over a period of two months (June and July 2016)...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29205443/digitized-evaluation-of-speech-intelligibility-using-vowels-in-maxillectomy-patients
#7
Yuka I Sumita, Mariko Hattori, Mai Murase, Mahmoud E Elbashti, Hisashi Taniguchi
BACKGROUND: Among the functional disabilities that patients face following maxillectomy, speech impairment is a major factor influencing quality of life. Proper rehabilitation of speech, which may include prosthodontic and surgical treatment and speech therapy, requires accurate evaluation of speech intelligibility (SI). A simple, less time-consuming yet accurate evaluation is desirable both for maxillectomy patients and the various clinicians providing maxillofacial treatment. OBJECTIVE: This study sought to determine the utility of digital acoustic analysis of vowels for the prediction of SI in maxillectomy patients, based on a comprehensive understanding of speech production in the vocal tract of maxillectomy patients and its perception...
December 4, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29204197/infantile-tremor-syndrome-in-modern-times
#8
Piyush Gautam, Nivedita Sharma, Sanjeev Chaudhary, Ankush Kaushal
Background: Infantile tremor syndrome (ITS) is a clinical syndrome of acute or gradual onset of mental and psychomotor changes, pigmentary disturbances of hair and skin, pallor, and tremors in malnourished children aged between 5 months and 3 years. It is a well-known entity, but the exact etiopathogenesis is still not known. Setting and Design: Prospective observational study carried out in the Department of Pediatrics at Dr RPGMC Tanda, Kangra in Himachal Pradesh...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29202919/stakeholders-guidance-document-for-consumer-analytical-devices-with-a-focus-on-gluten-and-food-allergens
#9
Bert Popping, Laura Allred, François Bourdichon, Kurt Brunner, Carmen Diaz-Amigo, Patricia Galan-Malo, Markus Lacorn, Jennifer North, Salvatore Parisi, Adrian Rogers, Jennifer Sealy-Voyksner, Tricia Thompson, Jupiter Yeung
Until recently, analytical tests for food were performed primarily in laboratories, but technical developmentsnow enable consumers to use devices to test their food at home or when dining out. Current consumer devices for food can determine nutritional values, freshness, and, most recently, the presence of food allergens and substances that cause food intolerances. The demand for such products is driven by an increase in the incidence of food allergies, as well as consumer desire for more information about what is in their food...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29202185/clinical-documentation-variations-and-nlp-system-portability-a-case-study-in-asthma-birth-cohorts-across-institutions
#10
Sunghwan Sohn, Yanshan Wang, Chung-Il Wi, Elizabeth A Krusemark, Euijung Ryu, Mir H Ali, Young J Juhn, Hongfang Liu
Objective: To assess clinical documentation variations across health care institutions using different electronic medical record systems and investigate how they affect natural language processing (NLP) system portability. Materials and Methods: Birth cohorts from Mayo Clinic and Sanford Children's Hospital (SCH) were used in this study (n = 298 for each). Documentation variations regarding asthma between the 2 cohorts were examined in various aspects: (1) overall corpus at the word level (ie, lexical variation), (2) topics and asthma-related concepts (ie, semantic variation), and (3) clinical note types (ie, process variation)...
November 30, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29201532/clinical-presentation-epidemiology-neurophysiological-findings-treatment-and-outcome-of-nonconvulsive-status-epilepticus-a-3-year-prospective-hospital-based-study
#11
Boulenouar Mesraoua, Dirk Deleu, Hassan Al Hail, Faisal Ibrahim, Gayane Melikyan, Hassan Al Hussein, Rajvir Singh, Basim Uthman, Leopold Streletz, Peter W Kaplan, Heinz Gregor Wieser
Objective: This study reports the prevalence of Nonconvulsive Status Epilepticus (NCSE) in patients with altered mental status (AMS), and describes the clinical presentation, etiology, neurophysiological findings, neuroimaging, treatment, and outcome of NCSE in Qatar. Recording duration of continuous EEG monitoring was also discussed. Methods: This was a 3-year, prospective, hospital-based study involving patients with AMS and continuous EEG monitoring admitted to the Emergency and ICUs of Hamad Hospital, Qatar...
2017: Journal of Drug Assessment
https://www.readbyqxmd.com/read/29200503/from-eminent-men-to-excellent-universities-university-rankings-as-calculative-devices
#12
Björn Hammarfelt, Sarah de Rijcke, Paul Wouters
Global university rankings have become increasingly important 'calculative devices' for assessing the 'quality' of higher education and research. Their ability to make characteristics of universities 'calculable' is here exemplified by the first proper university ranking ever, produced as early as 1910 by the American psychologist James McKeen Cattell. Our paper links the epistemological rationales behind the construction of this ranking to the sociopolitical context in which Cattell operated: an era in which psychology became institutionalized against the backdrop of the eugenics movement, and in which statistics of science became used to counter a perceived decline in 'great men...
2017: Minerva
https://www.readbyqxmd.com/read/29199662/efficacy-and-safety-of-first-line-systemic-chemotherapy-with-epirubicin-cisplatin-plus-5-fluorouracil-and-docetaxel-cisplatin-plus-5-fluorouracil-regimens-in-locally-advanced-inoperable-or-metastatic-gastric-or-gastroesophageal-junction-adenocarcinoma-a-prospective
#13
K G Babu, T Chaudhuri, K C Lakshmaiah, L Dasappa, L A Jacob, McS Babu, A H Rudresha, K N Lokesh, L K Rajeev
BACKGROUND: Patients with locally advanced inoperable or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma have a poor prognosis. The maximum benefit of systemic chemotherapy is usually achieved in the first-line setting. Even though systemic chemotherapy has been used for long time, in view of unsatisfactory results, no standard regimen has been emerged. Unfortunately, till date, there is no published prospective data from India, comparing the two most commonly used triplet regimens, epirubicin, cisplatin plus 5-fluorouracil (ECF) and docetaxel, cisplatin plus 5-fluorouracil (DCF), in this patient population...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29194262/application-of-yl-1-needle-in-chronic-subdural-hematoma-treatment-for-super-aged-patients
#14
Xifeng Fei, Yi Wan, Zhimin Wang, Hanchun Chen, Dongyi Jiang
OBJECTIVE: The proportion of the super-aged population (at the age of 80 or above) in patients with chronic subdural hematoma (CSDH) and the incidence of CSDH of the population have been increasing. Since it is widely accepted that YL-1 needle is effective in CSDH treatment, this paper aimed to probe into the efficacy of YL-1 needle in minimally invasive surgery for super-aged (at the age of 80-90) CSDH patients. METHODS: A retrospective analysis on the clinical information of 17 super-aged CSDH patients having received the YL-1 needle puncture treatment provided by the hospital from May 2012 to December 2016 was performed...
November 29, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29193632/lip-repositioning-for-the-treatment-of-excess-gingival-display-a-systematic-review
#15
REVIEW
Omnia K Tawfik, Hani E El-Nahass, Peter Shipman, Stephen W Looney, Christopher W Cutler, Mark Brunner
BACKGROUND: Lip repositioning is a conservative surgical technique used to treat excess gingival display. An array of modifications has been introduced to the technique over time and as studies show the technique and its modifications to be successful, there is little standardized information for clinicians to make informed decisions when choosing this technique for the treatment of patients with excessive gingival display (EGD). OBJECTIVES: To review the current literature on the topic of lip repositioning for the treatment of excessive EGD, exploring outcome, and result longevity...
November 27, 2017: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29190864/-administering-bars-in-children-with-ataxia-in-a-children-rehabilitation-center-in-chiapas-mexico
#16
Flor Guadalupe Perdomo-Rebollo, Anke Paula Ingrid Kleinert-Altamirano
BACKGROUND: Ataxias are an heterogeneous group of diseases with different etiologies. Scales are used to understand better its natural history and evaluate properly drug efficacy in clinical trials. SARA and ICARS scales have been the most studied and validated so far. BARS scale is based on a modified form of the ICARS scale and is valid, reliable and sufficiently fast for clinical purposes. METHODS: Cross-sectional, descriptive and correlational study. Kruskall-Wallis test was used...
November 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29190747/characterizing-the-heterogeneity-of-tumor-tissues-from-spatially-resolved-molecular-measures
#17
John F Graf, Maria I Zavodszky
BACKGROUND: Tumor heterogeneity can manifest itself by sub-populations of cells having distinct phenotypic profiles expressed as diverse molecular, morphological and spatial distributions. This inherent heterogeneity poses challenges in terms of diagnosis, prognosis and efficient treatment. Consequently, tools and techniques are being developed to properly characterize and quantify tumor heterogeneity. Multiplexed immunofluorescence (MxIF) is one such technology that offers molecular insight into both inter-individual and intratumor heterogeneity...
2017: PloS One
https://www.readbyqxmd.com/read/29189576/predicting-high-health-care-resource-utilization-in-a-single-payer-public-health-care-system-development-and-validation-of-the-high-resource-user-population-risk-tool-hruport
#18
Laura C Rosella, Kathy Kornas, Zhan Yao, Douglas G Manuel, Catherine Bornbaum, Randall Fransoo, Therese Stukel
BACKGROUND: A large proportion of health care spending is incurred by a small proportion of the population. Population-based health planning tools that consider both the clinical and upstream determinants of high resource users (HRU) of the health system are lacking. OBJECTIVE: To develop and validate the High Resource User Population Risk Tool (HRUPoRT), a predictive model of adults that will become the top 5% of health care users over a 5-year period, based on self-reported clinical, sociodemographic, and health behavioral predictors in population survey data...
November 17, 2017: Medical Care
https://www.readbyqxmd.com/read/29189348/should-transfusion-trigger-thresholds-differ-for-critical-care-versus-perioperative-patients-a-meta-analysis-of-randomized-trials
#19
Matthew A Chong, Rohin Krishnan, Davy Cheng, Janet Martin
OBJECTIVE: To address the significant uncertainty as to whether transfusion thresholds for critical care versus surgical patients should differ. DESIGN: Meta-analysis of randomized controlled trials. SETTING: Medline, EMBASE, and Cochrane Library searches were performed up to 15 June 2016. PATIENTS: Trials had to enroll adult surgical or critically ill patients for inclusion. INTERVENTIONS: Studies had to compare a liberal versus restrictive threshold for the transfusion of allogeneic packed RBCs...
November 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29189271/low-versus-high-chloride-content-intravenous-solutions-for-critically-ill-and-perioperative-adult-patients-a-systematic-review-and-meta-analysis
#20
Leticia Kawano-Dourado, Fernando G Zampieri, Luciano C P Azevedo, Thiago D Corrêa, Mabel Figueiró, Matthew W Semler, John A Kellum, Alexandre B Cavalcanti
BACKGROUND: To assess whether use of low-chloride solutions in unselected critically ill or perioperative adult patients for maintenance or resuscitation reduces mortality and renal replacement therapy (RRT) use when compared to high-chloride fluids. METHODS: Systematic review and meta-analysis with random-effects inverse variance model. PubMed, Cochrane library, EMBASE, LILACS, and Web of Science were searched from inception to October 2016. Published and unpublished randomized controlled trials in any language that enrolled critically ill and/or perioperative adult patients and compared a low- to a highchloride solution for volume maintenance or resuscitation...
November 14, 2017: Anesthesia and Analgesia
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