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https://www.readbyqxmd.com/read/29474302/association-between-early-anatomic-response-to-anti-vascular-endothelial-growth-factor-therapy-and-long-term-outcome-in-diabetic-macular-edema-an-independent-analysis-of-protocol-i-study-data
#1
Pravin U Dugel, Joanna H Campbell, Szilárd Kiss, Anat Loewenstein, Vanessa Shih, Xiaoshu Xu, Nancy M Holekamp, Albert J Augustin, Allen C Ho, Victor H Gonzalez, Scott M Whitcup
PURPOSE: This post hoc analysis explores the relationship between early retinal anatomical response and long-term anatomical and visual outcomes with ranibizumab in center-involved diabetic macular edema. METHODS: Eyes randomized to the ranibizumab plus prompt laser and ranibizumab plus deferred laser treatment arms in the Protocol I study were categorized according to their proportional reduction (<20 vs. ≥20%) in central retinal thickness (CRT) after 12 weeks...
February 22, 2018: Retina
https://www.readbyqxmd.com/read/29471700/methodological-concerns-with-the-meta-analysis-comparing-insulin-degludec-liraglutide-and-insulin-glargine-lixisenatide
#2
Sarah Eggert, Esther Zimmermann, Kamilla Begtrup
In a recent article published in Expert Opinion on Pharmacotherapy (Nov 5 2017), Cai XL and colleagues reported a systematic review and meta-analysis of randomized controlled trials of insulin degludec/liraglutide(IDegLira; Novo Nordisk) and insulin glargine/lixisenatide(IGlarLixi; Sanofi), both fixed ratio combinations (FRC) of a basal insulin and a glucagon-like peptide-1 receptor agonist (GLP-1RA) [1]. In the absence of head-to-head comparisons of drugs, meta-analyses can provide additional evidence not available from single trials; however, any conclusions must be based on proper methodology...
February 23, 2018: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29471557/prospective-comparison-of-a-metal-free-ceramic-total-knee-arthroplasty-with-an-identical-metal-system
#3
Klemens Trieb, David Ullmann, Katharina Metzinger, Reinhard Kramar, Andreas Mauerer, Stefan Hofstätter, Rainer Fiala
AIMS: The aim of this open-label, prospective, short-term study was to carry out an initial comparison of a completely metal-free ceramic with a geometrically identical metallic arthroplasty over a 1-year follow-up period. METHODS: This study investigates a completely metal-free system using a composite matrix material containing aluminum oxide (Al2 O3 , BPK-S Integration, Peter Brehm GmbH, Weisendorf, Germany) or zirconium oxide (ZrO2 , BPK-S Integration Ceramic, Biolox Delta-CeramTec GmbH, Plochingen, Germany)...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29470489/integration-of-machine-learning-and-meta-analysis-identifies-the-transcriptomic-bio-signature-of-mastitis-disease-in-cattle
#4
Somayeh Sharifi, Abbas Pakdel, Mansour Ebrahimi, James M Reecy, Samaneh Fazeli Farsani, Esmaeil Ebrahimie
Gram-negative bacteria such as Escherichia coli (E. coli) are assumed to be among the main agents that cause severe mastitis disease with clinical signs in dairy cattle. Rapid detection of this disease is so important in order to prevent transmission to other cows and helps to reduce inappropriate use of antibiotics. With the rapid progress in high-throughput technologies, and accumulation of various kinds of '-omics' data in public repositories, there is an opportunity to retrieve, integrate, and reanalyze these resources to improve the diagnosis and treatment of different diseases and to provide mechanistic insights into host resistance in an efficient way...
2018: PloS One
https://www.readbyqxmd.com/read/29468779/probabilistic-measures-of-climate-change-vulnerability-adaptation-action-benefits-and-related-uncertainty-from-maximum-temperature-metric-selection
#5
J Tyrell DeWeber, Tyler Wagner
Predictions of the projected changes in species distribution models and potential adaptation action benefits can help guide conservation actions. There is substantial uncertainty in projecting species distributions into an unknown future, however, which can undermine confidence in predictions or misdirect conservation actions if not properly considered. Recent studies have shown that the selection of alternative climate metrics describing very different climatic aspects (e.g., mean air temperature vs. mean precipitation) can be a substantial source of projection uncertainty...
February 22, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29468463/detecting-seasonal-and-cyclical-trends-in-agricultural-runoff-water-quality-hypothesis-tests-and-block-bootstrap-power-analysis
#6
Venkatesh Uddameri, Sreeram Singaraju, E Annette Hernandez
Seasonal and cyclic trends in nutrient concentrations at four agricultural drainage ditches were assessed using a dataset generated from a multivariate, multiscale, multiyear water quality monitoring effort in the agriculturally dominant Lower Rio Grande Valley (LRGV) River Watershed in South Texas. An innovative bootstrap sampling-based power analysis procedure was developed to evaluate the ability of Mann-Whitney and Noether tests to discern trends and to guide future monitoring efforts. The Mann-Whitney U test was able to detect significant changes between summer and winter nutrient concentrations at sites with lower depths and unimpeded flows...
February 21, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29467718/on-the-accurate-determination-of-shock-wave-time-pressure-profile-in-the-experimental-models-of-blast-induced-neurotrauma
#7
Maciej Skotak, Eren Alay, Namas Chandra
Measurement issues leading to the acquisition of artifact-free shock wave pressure-time profiles are discussed. We address the importance of in-house sensor calibration and data acquisition sampling rate. Sensor calibration takes into account possible differences between calibration methodology in a manufacturing facility, and those used in the specific laboratory. We found in-house calibration factors of brand new sensors differ by less than 10% from their manufacturer supplied data. Larger differences were noticeable for sensors that have been used for hundreds of experiments and were as high as 30% for sensors close to the end of their useful lifetime...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29464676/further-evidence-of-the-association-of-the-diacylglycerol-kinase-kappa-dgkk-gene-with-hypospadias
#8
Kamil Konrad Hozyasz, Adrianna Mostowska, Andrzej Kowal, Dariusz Mydlak, Alexander Tsibulski, Pawel P Jagodzinski
PURPOSE: Hypospadias is a common developmental anomaly of the male external genitalia. In previous studies conducted on West European, Californian, and Han Chinese populations the relationship between polymorphic variants of the diacylglycerol kinase kappa (DGKK) gene and hypospadias have been reported. The aim was to study the possible associations between polymorphic variants of the DGKK gene and hypospadias using an independent sample of the Polish population. MATERIALS AND METHODS: Ten single nucleotide polymorphisms in DGKK, which were reported to have an impact on the risk of hypospadias in other populations, were genotyped using high-resolution melting curve analysis in a group of 166 boys with isolated anterior (66%) and middle (34%) forms of hypospadias and 285 properly matched controls without congenital anomalies...
February 18, 2018: Urology Journal
https://www.readbyqxmd.com/read/29464470/open-flap-versus-flapless-placement-of-dental-implants-a-randomized-controlled-pilot-trial
#9
Enric Jané-Salas, Xavier Roselló-LLabrés, Enric Jané-Pallí, Siddharth Mishra, Raúl Ayuso-Montero, José López-López
The aim of this study was to compare the immediate postoperative period of participants rehabilitated with dental implants placed with a conventional technique or with a minimally invasive technique, without a mucoperiosteal flap elevation (flapless). Participants who needed implant placement were divided into two groups: one group was operated using a mucoperiosteal flap elevation (G_A), and the other with a flapless surgical technique (G_B). Objective clinical parameters including oral hygiene, mouth opening, inflammation (facial perimeter), surgical time and analgesic consumption, as well as subjective parameters of pain and degree of satisfaction with the procedure, were evaluated...
February 20, 2018: Odontology
https://www.readbyqxmd.com/read/29464215/accuracy-of-point-of-care-ultrasound-using-low-frequency-curvilinear-transducer-in-the-diagnosis-of-shoulder-dislocation-and-confirmation-of-appropriate-reduction
#10
Javad Seyedhosseini, Jaleh Saiidian, Amirpejman Hashemi Taheri, Elnaz Vahidi
Background: Ultrasound (US) is an effective modality in the evaluation of shoulder dislocation and reduction. In most studies, high frequency US probes have been used. Objective: To determine the sensitivity and specificity of low frequency US in the diagnosis of shoulder dislocation and its proper reduction in the emergency department (ED). Methods: In a prospective observational study 84 patients, suspicious of shoulder dislocation, were enrolled in our study...
December 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29462094/effects-of-abaloparatide-on-bone-mineral-density-and-risk-of-fracture-in-postmenopausal-women-aged-80-years-or-older-with-osteoporosis
#11
Michael R McClung, Nicholas C Harvey, Lorraine A Fitzpatrick, Paul D Miller, Gary Hattersley, Yamei Wang, Felicia Cosman
OBJECTIVE: Advanced age is an important risk factor for fracture. The Abaloparatide Comparator Trial In Vertebral Endpoints (ACTIVE) trial showed that subcutaneous abaloparatide increased bone mineral density (BMD) and reduced the risk of vertebral and nonvertebral fractures in postmenopausal women with osteoporosis. This study describes the effects of abaloparatide in the subgroup of women aged 80 or more years in ACTIVE. METHODS: Post hoc analyses of BMD and fracture incidence in this subgroup of women who received abaloparatide or placebo in the 18-month, phase 3, double-blind, randomized controlled ACTIVE trial...
February 16, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29461912/practice-and-attitudes-towards-immunization-among-lebanese-obstetricians-and-gynecologists
#12
Elie Hobeika, Ihab M Usta, Rami Helou, Salma Jabak, Faysal El Kak, Anwar H Nassar
We designed our study to evaluate the knowledge and immunization practices among Lebanese obstetricians and gynecologists (OBGYN) for women of different age groups. Anonymous questionnaires were used to assess the knowledge and immunization practices among OBGYN. The survey was conducted at the annual meeting of the Lebanese Society of Obstetrics and Gynecology on November 13-15, 2014. Data collected included demographics, type of practice, academic background and familiarity with vaccine guidelines. Descriptive statistical methods were used to evaluate the responses...
February 20, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29460042/spleen-enlargement-assessment-using-computed-tomography-which-coefficient-correlates-the-strongest-with-the-real-volume-of-the-spleen
#13
Iwona Kucybała, Szymon Ciuk, Justyna Tęczar
PURPOSE: The aim of the study was to find which linear measurements, field and volume coefficients correlate the best with real volume of the spleen and can be further used for identification of splenomegaly. METHODS: Abdominal computed tomography (CT) examinations of 264 patients were retrospectively analyzed in terms of maximal length, maximal thickness, hilum thickness, maximal height, vertical height and estimated height. Spleen volume was manually measured in Vitrea software...
February 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29456589/employment-status-and-changes-in-working-career-in-relation-to-asthma-a-cross-sectional-survey
#14
Saara Taponen, Lauri Lehtimäki, Kirsi Karvala, Ritva Luukkonen, Jukka Uitti
Background: Asthmatics confront inconveniences in working life that make it more difficult to pursue a sustainable career, such as unemployment and work disability. Ways of dealing with these inconveniences may be career changes. More needs to be known about the backgrounds and consequences of career changes among asthmatics, especially their relation to asthma or a change in asthma symptoms. The aim of this study was to compare earlier career changes of adults with asthma who are working full time to those who have drifted away from active working life because of work disability, unemployment or early retirement...
2018: Journal of Occupational Medicine and Toxicology
https://www.readbyqxmd.com/read/29456587/dietary-diversity-and-associated-factors-among-children-of-orthodox-christian-mothers-caregivers-during-the-fasting-season-in-dejen-district-north-west-ethiopia
#15
Gemechu Kumera, Endalkachew Tsedal, Mulatu Ayana
Background: Proper feeding practices during early childhood is fundamental for optimal child growth and development. However, scientific evidences on the determinants of dietary diversity are scanty. Particularly, the impact of fasting on children`s dietary diversity is not explored in Ethiopia. The aim of this study was to assess dietary diversity and associated factors among children aged 6-23 months, whose mothers/care-givers were Orthodox Christians during the fasting season (Lent), in Dejen District, North West Ethiopia, 2016...
2018: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29452282/load-sharing-through-elastic-micro-motion-accelerates-bone-formation-and-interbody-fusion
#16
Eric H Ledet, Glenn P Sanders, Darryl J DiRisio, Joseph C Glennon
BACKGROUND: Context: Achieving a successful spinal fusion requires the proper biologic and biomechanical environment. Optimizing load-sharing in the interbody space can enhance bone formation. For anterior cervical discectomy and fusion (ACDF), loading and motion are largely dictated by the stiffness of the plate which can facilitate a balance between stability and load-sharing. The advantages of load-sharing may be substantial for patients with comorbidities and in multi-level procedures where pseudarthrosis rates are significant...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29450195/insecticide-treated-nets-utilization-and-associated-factors-among-under-5-years-old-children-in-mirab-abaya-district-gamo-gofa-zone-ethiopia
#17
Amha Admasie, Amanuel Zemba, Wondimagegn Paulos
Background: Malaria can be prevented using cost-effective interventions. It can be prevented at large via the use of insecticide-treated mosquito nets (ITNs). The use of ITNs decreases malaria mortality rates by 55% in under-5 years old children in Africa, Ethiopia, realizing the effectiveness, scaling up distribution and utilization of ITNs to cover 100% of children less than 5 years of age. However, little is known about ITNs utilization and factors associated with the utilization in under-5 years old children in the study area yet...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29449758/an-assessment-of-forest-biomass-maps-in-europe-using-harmonized-national-statistics-and-inventory-plots
#18
Valerio Avitabile, Andrea Camia
Maps of aboveground forest biomass based on different input data and modelling approaches have been recently produced for Europe, opening up the possibility for several applications and products not obtainable by summary statistics. However, the accuracy assessment of the existing maps is limited by the lack of reference data consistent over the study region and representative of the maps cells. Here, we used harmonized forest biomass data for 26 European countries derived by National Forest Inventories using a common biomass definition and estimator to assess four biomass maps...
February 1, 2018: Forest Ecology and Management
https://www.readbyqxmd.com/read/29448439/modeling-the-complexity-of-acoustic-emission-during-intermittent-plastic-deformation-power-laws-and-multifractal-spectra
#19
Jagadish Kumar, G Ananthakrishna
Scale-invariant power-law distributions for acoustic emission signals are ubiquitous in several plastically deforming materials. However, power-law distributions for acoustic emission energies are reported in distinctly different plastically deforming situations such as hcp and fcc single and polycrystalline samples exhibiting smooth stress-strain curves and in dilute metallic alloys exhibiting discontinuous flow. This is surprising since the underlying dislocation mechanisms in these two types of deformations are very different...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29444609/optimization-of-resources-by-drug-management-a-multicentred-web-administered-study-on-the-use-of-ipilimumab-in-italy
#20
V Damuzzo, A Russi, M Chiumente, C Masini, B Rebesco, F Gregis, S Nozza, J Pigozzo, V Chiarion-Sileni, A C Palozzo
Objective In a scenario of new expensive cancer therapies entering the market, strategies of optimisation and cost containment are crucial in oncology care. Better management of drug waste and centralization of drug preparation can be effective strategies to achieve these goals. The aim of this work is to describe the economic management of a high cost anticancer drug (ipilimumab) in some Italian reference centres. Methods This was an observational, multicentred study in which economical and clinical data of 21 cancer centres (418 patients) were collected during the enrollment period from February 2013 to August 2014...
January 1, 2018: Journal of Oncology Pharmacy Practice
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