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https://www.readbyqxmd.com/read/29040644/displaying-and-analyzing-quality-improvement-data
#1
Patrick W Brady, Michael J Tchou, Lilliam Ambroggio, Amanda C Schondelmeyer, Erin E Shaughnessy
In this second article in the quality improvement (QI) methods series, we discuss how data are best displayed and analyzed in QI projects while focusing on some similarities with and differences from traditional clinical research. We demonstrate why displaying data over time on a run or control chart is superior to using pre-post analysis for QI studies. We introduce several types of statistical process control charts for data commonly collected during QI programs and provide guidance on how to use the proper chart...
October 5, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29038624/comparing-the-efficiency-of-two-different-extraction-techniques-in-removal-of-maxillary-third-molars-a-randomized-controlled-trial
#2
Joseph Edward, Mubarak A Aziz, Arjun Madhu Usha, Jyothi K Narayanan
INTRODUCTION: Extractions are routine procedures in dental surgery. Traditional extraction techniques use a combination of severing the periodontal attachment, luxation with an elevator, and removal with forceps. A new technique of extraction of maxillary third molar is introduced in this study-Joedds technique, which is compared with the conventional technique. METHODS AND MATERIAL: One hundred people were included in the study, the people were divided into two groups by means of simple random sampling...
December 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29036714/accounting-for-technical-noise-in-differential-expression-analysis-of-single-cell-rna-sequencing-data
#3
Cheng Jia, Yu Hu, Derek Kelly, Junhyong Kim, Mingyao Li, Nancy R Zhang
Recent technological breakthroughs have made it possible to measure RNA expression at the single-cell level, thus paving the way for exploring expression heterogeneity among individual cells. Current single-cell RNA sequencing (scRNA-seq) protocols are complex and introduce technical biases that vary across cells, which can bias downstream analysis without proper adjustment. To account for cell-to-cell technical differences, we propose a statistical framework, TASC (Toolkit for Analysis of Single Cell RNA-seq), an empirical Bayes approach to reliably model the cell-specific dropout rates and amplification bias by use of external RNA spike-ins...
September 25, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29035546/the-gradient-adaptive-decomposition-grad-method-optimized-refinement-along-macrostate-borders-in-markov-state-models
#4
Pablo G Romano, Marina Giuseppina Guenza
Markov State Models (MSM) are used to model the kinetics of processes sampled by Molecular Dynamics (MD) simulations. MSM reduce the high dimensionality inherent to MD simulations as they partition the free energy landscape into discrete states, generating a kinetic model as a series of uncorrelated jumps between states. Here, we detail a new method, called GRadient Adaptive Decomposition, which optimizes coarse-grained MSM by refining borders with respect to the gradient along the free energy surface. The proposed method requires only a small number of initial microstates because it corrects for errors produced by limited sampling...
October 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29032910/venous-thromboembolism-after-laparoscopic-or-robotic-biliopancreatic-diversion-with-duodenal-switch-ninety-days-outcome-of-a-10-years-experience
#5
Hamzeh M Halawani, Charis F Ripley-Hager, Mary C Naglak, Fernando Bonanni, Gintaras Antanavicius
BACKGROUND: Venous thromboembolism (VTE) is a feared complication after bariatric surgery. Biliopancreatic diversion with duodenal switch (BPD-DS) is a complex bariatric procedure that is offered typically to super morbidly obese patients. Scarce data exist in reporting VTE outcome and identifying the risk factors associated with it after BPD-DS. OBJECTIVE: To determine the risk factors for VTE after BPD-DS at 90-day follow-up. SETTING: A nonprofit regional referral center and teaching hospital in Pennsylvania...
September 9, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29032816/physicochemical-properties-and-volumetric-change-of-silicone-bioactive-glass-and-calcium%C3%A2-silicate-based-endodontic-sealers
#6
Mario Tanomaru-Filho, Fernanda Ferrari Esteves Torres, Gisselle Moraima Chávez-Andrade, Madelise de Almeida, Luciana Guilherme Navarro, Liviu Steier, Juliane Maria Guerreiro-Tanomaru
INTRODUCTION: This study evaluated setting time (ST), radiopacity, pH, flow, solubility, and volumetric change (VC) of a silicone, gutta-percha, and bioactive glass-based sealer, GuttaFlow Bioseal (GFB), and a calcium silicate-based sealer, TotalFill BC Sealer (TFBC), in comparison with AH Plus. METHODS: ST and flow were evaluated in accordance with the ISO 6876 Standard. pH was evaluated after different time intervals (1, 3, 7, 14, 21, and 28 days). Radiopacity was evaluated by radiographic analysis in millimeters of aluminum...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29031946/spermatozoa-dna-methylation-patterns-differ-due-to-peripubertal-age-in-bulls
#7
Simon Lambert, Patrick Blondin, Christian Vigneault, Rémi Labrecque, Isabelle Dufort, Marc-André Sirard
In the dairy industry, using semen as soon as the bull is mature enough to produce it is advantageous for breeding purposes. Mammalian spermatogenesis is a hormone-dependent developmental program in which a complex cascade of events must take place to ensure that germ cells reach the proper stage of development at the proper time. Conventional indicators of semen quality such as sperm cell motility and viability usually improve as bulls mature, meeting quality criteria satisfactorily at around 16 months. Using semen before that age may affect embryo viability, but other changes occurring during the peripubertal period should be considered...
October 6, 2017: Theriogenology
https://www.readbyqxmd.com/read/29028435/evaluation-of-agricultural-interventions-on-human-and-poultry-related-salmonella-enteritidis-in-british-columbia
#8
Marsha Taylor, William Cox, Michael Otterstatter, Nancy de With, Eleni Galanis
A collaborative investigation between public health and animal health led to numerous interventions along the food chain in response to an outbreak of human salmonellosis and increased incidence of Salmonella Enteritidis (SE) among poultry. Incidence of both human and chicken SE decreased substantially in 2012 and 2013 following these interventions. We used time series analysis to assess the impact of three interventions: vaccination of broiler breeder flocks, separation in the hatchery of breeder eggs, and an industry order to stop farm-gate sales of ungraded broiler hatching eggs...
October 13, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29026728/analysis-of-the-relationship-between-sleep-duration-and-body-mass-index-in-a-south-korean-adult-population-a-propensity-score-matching-approach
#9
Baksun Sung
BACKGROUND: One-third of the present adults in South Korea are obese, and previous studies have demonstrated that sleep duration is considered a risk factor for obesity. Hence, I assessed the relationship between sleep duration and body mass index in a South Korean adult population. METHODS: This cross-sectional study consists of a representative sample of 4,218 South Korean adults (20-64 years) who participated in the sixth Korea National Health and Nutrition Examination Survey (2015)...
July 2017: Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/29025746/clinical-prediction-model-for-time-in-therapeutic-range-while-on-warfarin-in-newly-diagnosed-atrial-fibrillation
#10
Brent A Williams, Michael A Evans, Ashley M Honushefsky, Peter B Berger
BACKGROUND: Though warfarin has historically been the primary oral anticoagulant for stroke prevention in newly diagnosed atrial fibrillation (AF), several new direct oral anticoagulants may be preferred when anticoagulation control with warfarin is expected to be poor. This study developed a prediction model for time in therapeutic range (TTR) among newly diagnosed AF patients on newly initiated warfarin as a tool to assist decision making between warfarin and direct oral anticoagulants...
October 12, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29022132/an-exploratory-study-of-the-electronic-medical-record-and-outpatient-vascular-neurology-consultations
#11
Larissa Georgeon, Philip B Gorelick, Tenko Raykov, Muhammad U Farooq, Jiangyong Min, Christopher Goshgarian, Bradley Haveman-Gould, Amy Groenhout, Molly McCarthy
We carried out a quality improvement project utilizing the electronic medical record (EMR) to determine (1) the quality of vascular neurologists' recommendations for recurrent stroke prevention and (2) primary care provider (PCP) acknowledgement of the vascular neurologists' recurrent stroke prevention recommendations and their frequency of meeting the recommended metrics for risk factor control and lifestyle modification. We conducted a retrospective EMR chart review on a convenience sample of ischemic stroke patients during two epochs...
October 11, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29022096/the-association-between-ambient-temperature-and-childhood-asthma-a-systematic-review
#12
REVIEW
Zhiwei Xu, James Lewis Crooks, Janet Mary Davies, Al Fazal Khan, Wenbiao Hu, Shilu Tong
The objectives of this study are to review available information on the association between ambient temperature and childhood asthma, and to elucidate the possible underlying mechanisms of this relationship. A systematic review was conducted based on the papers retrieved from four databases, including PubMed, ProQuest, ScienceDirect, and Scopus. Papers examining the association of absolute temperature or temperature variation with childhood asthma published from 1 January 2000 to 31 December 2016 were included...
October 11, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29020855/retrospective-chart-evaluation-of-hypercalcemia-management-in-oncology-patients-at-the-university-of-chicago-medical-center
#13
Kelly Plach, Randall W Knoebel, Rita Nanda, Katherine Shea
Introduction Due to the lack of formal guideline recommendations, available primary literature was used to develop a proposed protocol for management of hypercalcemia of malignancy at the University of Chicago Medical Center. Methods A retrospective, single center, observational study was performed including adult patients hospitalized with a diagnosis of hypercalcemia and active malignancy. Patients were retrospectively identified as treated in a manner aligned with the proposed protocol ("per protocol") or not treated according to the proposed protocol ("off protocol"), and the outcomes were compared...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29020707/surgical-skills-improvement-using-a-low-cost-laparoscopic-simulator-for-ventral-incisional-hernia
#14
Vincenzo Consalvo, Vincenzo Salsano
INTRODUCTION: Ventral incisional hernia is one of the most common procedures in laparoscopic surgery, however, it requires proper training before doing it in the operating room. We propose a low-cost mechanical simulator with a new optical system to learn the basic steps of the procedure and improve surgical laparoscopic skill. MATERIALS AND METHODS: From November 3, 2014 to January 4, 2015, five residents and five surgeons with no prior laparoscopic experience, as well as two laparoscopic expert surgeons, participated in our study...
October 12, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29019130/dige-analysis-of-human-tissues
#15
Cecilia Gelfi, Daniele Capitanio
Two-dimensional difference gel electrophoresis (2-D DIGE) is an advanced and elegant gel electrophoretic analytical tool for comparative protein assessment. It is based on two-dimensional gel electrophoresis (2-DE) separation of fluorescently labeled protein extracts. The tagging procedures are designed to not interfere with the chemical properties of proteins with respect to their pI and electrophoretic mobility, once a proper labeling protocol is followed. The two-dye or three-dye systems can be adopted and their choice depends on specific applications...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29016375/the-impact-of-medication-anticholinergic-burden-on-cognitive-performance-in-people-with-schizophrenia
#16
Mei San Ang, Nur Amirah Abdul Rashid, Max Lam, Attilio Rapisarda, Michael Kraus, Richard S E Keefe, Jimmy Lee
BACKGROUND: Cognitive deficits are prevalent in people with schizophrenia and associated with functional impairments. In addition to antipsychotics, pharmacotherapy in schizophrenia often includes other psychotropics, and some of these agents possess anticholinergic properties, which may impair cognition. The objective of this study was to explore the association between medication anticholinergic burden and cognition in schizophrenia. METHODS: Seven hundred five individuals with schizophrenia completed a neuropsychological battery comprising Judgment of Line Orientation Test, Wechsler Abbreviated Scale of Intelligence Matrix Reasoning, Continuous Performance Test-Identical Pairs Version, and the Brief Assessment of Cognition in Schizophrenia...
October 9, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29016123/proselection-a-novel-algorithm-to-select-proper-protein-structure-subsets-for-in-silico-target-identification-and-drug-discovery-research
#17
Nanyi Wang, Lirong Wang, Xiang-Qun Sean Xie
Molecular docking is widely applied to computer-aided drug design and has become relatively mature in the recent decades. Application of docking in modeling varies from single lead compound optimization to large-scale virtual screening. The performance of molecular docking is highly dependent on the protein structures selected. It is especially challenging for large-scale target prediction research when multiple structures are available for a single target. Therefore, we have established ProSelection, a docking preferred-protein selection algorithm, in order to generate the proper structure subset(s)...
October 10, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28991301/mathematical-models-of-cytotoxic-effects-in-endpoint-tumor-cell-line-assays-critical-assessment-of-the-application-of-a-single-parametric-value-as-a-standard-criterion-to-quantify-the-dose-response-effects-and-new-unexplored-proposal-formats
#18
Ricardo C Calhelha, Mireia A Martínez, M A Prieto, Isabel C F R Ferreira
The development of convenient tools for describing and quantifying the effects of standard and novel therapeutic agents is essential for the research community, to perform more precise evaluations. Although mathematical models and quantification criteria have been exchanged in the last decade between different fields of study, there are relevant methodologies that lack proper mathematical descriptions and standard criteria to quantify their responses. Therefore, part of the relevant information that can be drawn from the experimental results obtained and the quantification of its statistical reliability are lost...
October 9, 2017: Analyst
https://www.readbyqxmd.com/read/28991066/defense-automated-neurobehavioral-assessment-accurately-measures-cognition-in-patients-undergoing-electroconvulsive-therapy-for-major-depressive-disorder
#19
Kristen R Hollinger, Steven R Woods, Alexis Adams-Clark, So Yung Choi, Caroline L Franke, Ryoko Susukida, Carol Thompson, Irving M Reti, Adam I Kaplin
OBJECTIVES: The Defense Automated Neurobehavioral Assessment (DANA) is an electronic cognitive test battery. The present study compares DANA to the standard Mini-Mental State Examination (MMSE) in subjects undergoing electroconvulsive therapy for the treatment of major depressive disorder. METHODS: Seventeen inpatient subjects in the Johns Hopkins Hospital Department of Psychiatry were administered longitudinal paired DANA and MMSE tests (7.6 ± 4.1 per patient) from January 10, 2014 to September 26, 2014...
October 3, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28991053/building-professionalism-through-management-training-new-england-public-health-training-center-s-low-cost-high-impact-model
#20
Kathleen MacVarish, Hope Kenefick, Anne Fidler, Bradley Cohen, Yuri Orellana, Karla Todd
CONTEXT: Evolving practices, accreditation, and priorities established in Public Health 3.0 are adding to the long-identified need for management training among public health practitioners. PROGRAM: The New England Public Health Training Center is addressing this need with a flexible, open-source, 16-topic training program. The program is designed to build competencies for current and future managers, preparing them for their day-to-day tasks and for the kinds of adaptation suggested by Public Health 3...
October 5, 2017: Journal of Public Health Management and Practice: JPHMP
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