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lupus pericarditis cyclosporine

R Kato, S Sumitomo, K Kawahata, K Fujio, K Yamamoto
A 39-year-old woman with a six-year history of systemic lupus erythematosus (SLE) was admitted because of a prolonged high fever, discoid rash, and multiple lymphadenopathies. She also developed pericarditis, and was treated with intravenous methylprednisolone pulse therapy followed by prednisolone 50 mg daily and cyclosporine 100 mg daily. Meanwhile, she had a progressive headache, and a brain MRI revealed right pons infarction, although she did not have any abnormal neurological findings. An MRA revealed obvious irregular narrowing in the basilar, right vertebral and right posterior cerebral artery...
July 2015: Lupus
Olivier Lambotte, Mehdi Khellaf, Hicham Harmouche, Brigitte Bader-Meunier, Véronique Manceron, Cécile Goujard, Zahir Amoura, Bertrand Godeau, Jean-Charles Piette, Jean-François Delfraissy
Reactive hemophagocytic syndrome (HS) occurs mainly in the setting of serious infections and lymphomas. HS can occur in the course of 2 active systemic diseases, without simultaneous infection: adult Still disease and systemic lupus erythematosus (SLE). Observations of specific lupus-associated HS are rare, and the long-term outcome of these patients with active SLE is unknown. We retrospectively studied 15 episodes of SLE-associated HS in 12 patients (10 women, 2 men) and noted the long-term outcome. HS occurred at a mean age of 25 years...
May 2006: Medicine (Baltimore)
Naohiko Moriguchi, Wakako Sato, Hiroshi Miyata, Kazuo Yoshioka
We investigated changes in various serum cytokines in a case of systemic lupus erythematosus (SLE) accompanied by hemophagocytic syndrome (HPS). The patient, a 15-year-old male, presented in December 1998 with bilateral salivary gland swelling and a history of fever continuing for more than 10 days. After admission, cerebellar ataxia and clouding of consciousness developed. Laboratory examinations revealed leukopenia, thrombocytopenia, high serum LDH and ferritin, hypercytokinemia, and prominent hemophagocytosis in the bone marrow...
October 2002: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
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