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clinical setting etiologies primary regimens

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June 2016: Annals of Intensive Care
Emily D Privette, Gita Ram, James R Treat, Albert C Yan, Jennifer R Heimall
Ataxia-telangiectasia (AT) is a rare autosomal recessive disorder characterized by faulty DNA damage repair. The disease affects multiple systems and is noted to be particularly difficult to diagnose in children because of the wide spectrum of clinical presentations. We present an unusual case of a child in whom the primary cutaneous manifestation of AT was noninfectious cutaneous caseating granulomas. A 3-year-old girl presented to the emergency department with ataxia, poor growth, and multiple ulcerated plaques on both upper extremities that had been present for 2 years...
November 2014: Pediatric Dermatology
Curtis Waycaster, Catherine T Milne
OBJECTIVE: The purpose of this study was to determine the cost-effectiveness of enzymatic debridement using collagenase relative to autolytic debridement with a hydrogel dressing for the treatment of pressure ulcers. METHODS: A 3-stage Markov model was used to determine the expected costs and outcomes of wound care for collagenase and hydrogel dressings. Outcome data used in the analysis were taken from a randomized clinical trial that directly compared collagenase and hydrogel dressings...
July 2013: Journal of Medical Economics
Gisella Vischini, Pasquale Niscola, Michele Ferrannini, Luca Cupelli, Andrea Tendas, Laura Scaramucci, Marco Giovannini, Teresa Dentamaro, Paolo de Fabritiis, Roberto Palumbo
Renal injury associated with hematopoietic stem cell transplant (HSCT) may be related to a combination of factors. Chronic graft-versus-host disease (cGVHD) is the most common complication of allogeneic HSCT. Although the kidneys are not considered the primary target organs for GVHD, chronic impairment of renal function may occur in 20% to 60% of HSCT patients. Membranous glomerulonephritis (MG) is the most frequent renal complication observed in patients who develop nephrotic syndrome after allogeneic HSCT...
July 2012: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Graeme F Woodworth, Alfred See, Chetan Bettegowda, Sachin Batra, George I Jallo, Daniele Rigamonti
OBJECTIVE: Endoscopic third ventriculostomy (ETV) is being used increasingly in adults as an alternative to cerebrospinal fluid (CSF) shunting. We analyze patient, radiographic, and operative factors associated with CSF diversion surgery-free outcomes after ETV. METHODS: One hundred twenty four consecutive adult patients (>18 years) treated with ETV at an academic institution were retrospectively reviewed according to demographic, clinical, operative, radiographic, and follow-up variables...
September 2012: World Neurosurgery
James Q Del Rosso
Rosacea is a prevalent inflammatory skin disorder that affects approximately 16 million individuals in the United States. Although its exact etiology is unknown, basic science, histologic evidence, and clinical evidence suggest that it is inflammatory in nature. In this 12-week, open-label, multicenter, community-based, phase 4 trial, we evaluated the anti-inflammatory effects of once daily subantimicrobial-dose doxycycline 40 mg (30-mg immediate-release and 10-mg delayed-release beads) in participants with papulopustular rosacea (PPR) who were receiving topical therapy (metronidazole, azelaic acid, and/ or sodium sulfacetamide-sulfur) at the time of the study entry but whose rosacea symptoms were still present...
November 2010: Cutis; Cutaneous Medicine for the Practitioner
John Segreti, Hans R House, Robert E Siegel
Community-acquired pneumonia (CAP) is a common illness with high rates of morbidity and mortality. Nearly 80% of the treatment for this condition is provided in the outpatient setting. Among the etiologic agents associated with bacterial CAP, the predominant pathogen is Streptococcus pneumoniae. Treatment of CAP for the most part is empirical; therefore, any antibiotic treatment should cover both typical and atypical pathogens. The beta-lactams have historically been considered standard therapy for the treatment of CAP...
July 2005: American Journal of Medicine
B Lovejoy
PURPOSE: To describe the etiology, clinical manifestations, differential diagnosis, and treatment of chronic bacterial and chronic abacterial prostatitis (CBP and CAP respectively) in the primary care setting. DATA SOURCES: Selected research, clinical guidelines, and research-based articles in the scientific literature. CONCLUSIONS: Most cases of CBP can be appropriately diagnosed and treated in the primary care office. In the case of a diagnosis of CAP, initial therapy can be started by the nurse practitioner (NP) with referral to a urologist for refractory cases...
July 2001: Journal of the American Academy of Nurse Practitioners
Complex regional pain syndrome-reflex sympathetic dystrophy (CRPS/RSD) is a complex pain-dysfunction syndrome of unknown cause that typically affects a single extremity. Changes are usually more marked peripherally. There are no generally accepted clinical diagnostic criteria or laboratory studies for CRPS/RSD; our current state of knowledge allows the diagnosis to be made only on clinical grounds. Clinical suspicion should be raised if pain and disability are greater than would usually be expected as a result of the original incident, if recovery is slower than expected, and if autonomic changes are prominent in the affected extremity...
November 1999: Current Treatment Options in Neurology
H Padma-Nathan
The recent introduction of sildenafil has revolutionized the treatment of erectile dysfunction (ED). The availability of sildenafil, the first effective oral agent for ED, has also expanded the field of sexual healthcare to include general and primary care practitioners and other nonurology specialists. A new process-of-care algorithm has been developed to facilitate the evaluation and treatment of ED in these nonurology settings. Sildenafil has been demonstrated to be safe and effective in randomized, double-blind, placebo-controlled trials involving >3,000 men ages 19-87 years...
September 9, 1999: American Journal of Cardiology
J D Conger
A variety of therapeutic approaches have been used both to prevent acute ischemic and nephrotoxic renal injury and to improve renal function and reduce mortality once acute renal failure (ARF) has developed. Unfortunately, there have been few rigorous assessments of the efficacy of these treatment interventions. The reasons for the lack of abundant critical data regarding treatment effects in ARF are several. First, ARF is a functional disorder. It has a spectrum of etiologies, occurs in a variety of clinical settings and varies in severity...
October 1995: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
M J Ault, A G Ellrodt
The term "hypertensive crisis" refers to a group of acute hypertensive disorders that have, in common, evidence of end-organ dysfunction. From a pathophysiological viewpoint, these disorders may be classified into two major categories. In primary hypertensive disorders, the predominant pathophysiological events and subsequent end-organ failure are directly attributable to the uncontrolled hypertension. Secondary hypertensive crises have many similar features; however, the ultimate progression from onset of hypertension to end-organ failure tends to be modified by concurrent target-organ disease...
December 1985: American Journal of Emergency Medicine
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