David Kalfert, Marie Ludvikova, Martin Pesta, Tommi Hakala, Lucie Dostalova, Hana Grundmannova, Jindra Windrichova, Katerina Houfkova, Tereza Knizkova, Jaroslav Ludvik, Jiri Polivka, Ivana Kholova
Mutations in cancer-related genes are now known to be accompanied by epigenetic events in carcinogenesis by modification of the regulatory pathways and expression of genes involved in the pathobiology. Such cancer-related mutations, miRNAs and gene expression may be promising molecular markers of the most common papillary thyroid carcinoma (PTC). However, there are limited data on their relationships. The aim of this study was to analyse the interactions between BRAF mutations, selected microRNAs (miR-21, miR-34a, miR-146b, and miR-9) and the expression of selected genes (LGALS3, NKX2-1, TACSTD2, TPO) involved in the pathogenesis of PTC...
April 23, 2024: Pathology, Research and Practice