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Follicular thyroid cancer

Sascha Kopp, Marcus Krüger, Stefan Feldmann, Hergen Oltmann, Andreas Schütte, Burkhard Schmitz, Johann Bauer, Herbert Schulz, Kathrin Saar, Norbert Huebner, Markus Wehland, Mohamed Zakaria Nassef, Daniela Melnik, Stefan Meltendorf, Manfred Infanger, Daniela Grimm
Human follicular thyroid cancer cells (FTC-133) were sent to space via a sounding rocket during the TEXUS-53 mission to determine the impact of short-term microgravity on these cells. To enable cell culture and fixation in real microgravity, an automated experiment container (EC) was constructed. In order to ensure safe cell culture, cell-chambers consisting of polycarbonate (PC) material were used. They were highly biocompatible as proved by measuring cell survival using Annexin V flow cytometry. In the follow-up experiment, FTC-133 cells were sent to space via a sounding rocket and were fixed before and after the microgravity (µg) phase with RNAlater...
July 9, 2018: Scientific Reports
Zhiwei Liu, Parag Mahale, Eric A Engels
Background: Sepsis is an important cause of mortality among older adults in the United States. The association between sepsis and subsequent risk of cancer is poorly understood. Methods: We conducted a case-control study in US adults using the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database. We included 1,801,156 cases with a first cancer diagnosis in SEER during 1992-2013 (ages 66-115 years) and 200,000 cancer-free controls from a 5% random sample of Medicare beneficiaries...
July 4, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Jalal Raoufi, Serhan Can İşcan, Candost Hanedan, Emine Elif Özkan, Sevim Süreyya Çerçi, Ebru Erdemoğlu, Evrim Erdemoğlu
Objective: There is scarce information about axillary lymph node involvement in gynecologic cancers. We analyzed the incidence of suspicious axillary lymph nodes in gynecologic cancers. Materials and Methods: We retrospectively analyzed the positron emission tomography/computed tomography findings of 251 patients with endometrial, cervical, and ovarian cancer. There is no cut-off value documented for axillary metastases from gynecologic cancers; therefore we adopted the cut-off standardized uptake values (SUVs) proclaimed in breast cancer...
June 2018: Turkish Journal of Obstetrics and Gynecology
Joon Ho Jang, So Hyun Park, Kyung Soon Cho, Won Kyung Cho, Young Jin Suh, Byung Kyu Suh, Dae Kyun Koh
PURPOSE: To determine the prevalence and clinical findings of benign thyroid nodules and cancer in Korean pediatric patients with thyroid nodules. METHODS: We investigated the medical records of 134 patients aged younger than 18 years who had a goiter, thyroid nodule, thyroid mass, or thyroid cancer who underwent fine needle aspiration biopsy (FNAB). RESULTS: The study population included 113 females (84.3%) and 21 males (13.7%); the mean patient age was 16...
June 2018: Annals of Pediatric Endocrinology & Metabolism
Xiang Min, Kai Liu, Hengtao Zhu, Jian Zhang
BACKGROUND The aim of this study was to explore the potential effects of long noncoding RNA (lncRNA) LINC003121 on thyroid cancer (TC) cell proliferation and invasion and to explore their possible mechanisms with the involvement of the PI3K/Akt signaling pathway. MATERIAL AND METHODS We enrolled 211 thyroid cancer tissues and 70 adjacent normal tissues in this study. TC cell lines K1, SW579, and 8505C and the human thyroid follicular cell line Nthy-ori3-1 were selected and assigned into blank, control vectors, LINC00312 vectors, si-control, and si-LINC00312 groups...
July 3, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
T M Myshunina, B D Guda, M Yu Bolgov, N I Mikhailenko, N D Tronko
AIM: To determine biological and clinical features of papillary and follicular thyroid carcinomas associated or not associated with chronic thyroiditis. MATERIALS AND METHODS: The study was conducted by retrospective analysis of medical histories of 2,459 patients with thyroid cancer. Tumor size, its category according to the TNM system, multi-focal properties of tumor growth, carcinoma invasiveness, as well as disease stage, rates of relapses and metastasis, and also cumulative survival rates were analyzed...
June 2018: Experimental Oncology
Gustavo C Penna, Ana Pestana, José Manuel Cameselle, Denise Momesso, Fernanda Accioly de Andrade, Ana Paula Aguiar Vidal, Mario Lucio Araujo Junior, Miguel Melo, Priscila Valverde Fernandes, Rossana Corbo, Mario Vaisman, Manuel Sobrinho-Simões, Paula Soares, Fernanda Vaisman
PURPOSE: Evaluate the impact of TERTp mutation on the outcomes after initial treatment of 45 patients with thyroid carcinomas derived from follicular cells (TCDFC) with aggressive histology, in which the role of this mutation is not yet well defined. METHODS: Analysis of the presence of TERTp (-124C > T and -146C > T), BRAF (V600E), and NRAS (Q 61R) mutations by Sanger sequencing and analysis of their correlation with the patient's outcomes. RESULTS: Forty-five patients with aggressive histopathologic variants were included in the study...
June 15, 2018: Endocrine
Hosu Kim, Hye In Kim, Sun Wook Kim, Jaehoon Jung, Min Ji Jeon, Won Gu Kim, Tae Yong Kim, Hee Kyung Kim, Ho Cheol Kang, Ji Min Han, Yoon Young Cho, Tae Hyuk Kim, Jae Hoon Chung
BACKGROUND: Most patients with differentiated thyroid cancer (DTC) have a favorable prognosis. However, patients with DTC and initial distant metastasis have not been commonly found, and their clinical characteristics have seldom been reported. In this study, we analyzed the clinical features and prognosis of patients with DTC and initial distant metastasis in Korea. METHODS: We retrospectively reviewed the clinical data of 242 patients with DTC and initial distant metastasis treated from 1994 to 2013, collected from five tertiary hospitals in Korea...
June 2018: Endocrinology and Metabolism
Mozhgan Karimifar
Thyroid follicular cancers are one of the thyroid gland cancers. This cancer can lead to metastases to various areas of the body. We describe a patient with thyroid follicular carcinoma who after total thyroidectomy had severe hypercalcemia, increased creatinine, and thyrotoxicosis due to extensive bone metastases. The patient was a 52-year-old man who had femoral neck fracture as the first manifestation of thyroid cancer. He was hospitalized for some time after orthopedic measures because of thyrotoxicosis and deep-venous thrombosis...
2018: Advanced Biomedical Research
Thomas J Semrad, Theresa Keegan, Alison M Semrad, Ann Brunson, D Gregory Farwell
BACKGROUND: In an era of rising differentiated thyroid cancer incidence, the rate and impact of neck reoperation may inform the intensity of earlier interventions and surveillance. In this study, we sought to define predictors of neck reoperation and to assess its impact on survival. METHODS: Using California Cancer Registry linked to California Office of Statewide Health Planning and Development records, we performed a retrospective cohort study of 24,230 patients with total or near total thyroidectomy for papillary or follicular thyroid cancer during 1991-2008 and follow up through 2013...
June 21, 2018: Thyroid: Official Journal of the American Thyroid Association
Sunmi Park, Mark Willingham, Jun Qi, Sheue-Yann Cheng
Compelling epidemiological evidence shows a strong positive correlation of obesity with thyroid cancer. In vivo studies have provided molecular evidence that high-fat-diet-induced obesity promotes thyroid cancer progression by aberrantly activating leptin-JAK2-STAT3 signaling in a mouse model of thyroid cancer (ThrbPV/PVPten+/- mice). The ThrbPV/PVPten+/- mouse expresses a dominantly negative thyroid hormone receptor β (denoted as PV) and a deletion of one single allele of the Pten gene. The ThrbPV/PVPten+/- mouse spontaneously develops follicular thyroid cancer, which allows its use as a preclinical mouse model to test potential therapeutics...
June 18, 2018: Endocrine-related Cancer
Thao T Nguyen, Natascha G E Lange, Anne L Nielsen, Anders Thomassen, Helle Døssing, Christian Godballe, Max Rohde
PURPOSE: To examine whether addition of 18 F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) to fine needle aspiration biopsy (FNAB) would improve prediction of thyroid cancer in patients with FNAB-derived follicular neoplasm or atypia, classified according to focal, multifocal, diffuse, or no FDG uptake. MATERIALS AND METHODS: Consecutive patients with FNAB-derived follicular neoplasm or atypia planned for surgery from September 2013 to March 2016 were prospectively included and considered for analysis...
June 16, 2018: European Archives of Oto-rhino-laryngology
Joanna Depciuch, Agata Stanek-Widera, Dariusz Lange, Magdalena Biskup-Frużyńska, Jadwiga Stanek-Tarkowska, Wojciech Czarny, Jozef Cebulski
Thyroid cancer holds the first place of the malignant tumors of the endocrine system. One of the less common thyroid cancers is follicular thyroid carcinoma (FTC), which is very difficult to diagnose because it gives the same image as adenoma, which is benign. Certainty of the diagnosis is gained only when FTC gives metastases. Therefore, it was decided to compare normal and neoplastic (FTC) thyroid tissues with Fourier Transform Infrared (FTIR) spectroscopy. The obtained FTIR spectra and Principal Component Analysis (PCA) allowed us to conclude that there are differences in the FTIR spectrum between normal tissues and those affected by cancer...
June 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Zunfu Ke, Yihao Liu, Yunjian Zhang, Jie Li, Ming Kuang, Sui Peng, Jinyu Liang, Shuang Yu, Lei Su, Lili Chen, Cong Sun, Bin Li, Jessica Cao, Weiming Lv, Haipeng Xiao
Differentiation of benign and malignant thyroid nodules is crucial for clinical management. Here, we explored the efficacy of next‑generation sequencing (NGS) in predicting the classification of benign and malignant thyroid nodules and lymph node metastasis status, and simultaneously compared the results with ultrasound (US). Thyroline was designed to detect 15 target gene mutations and 2 fusions in 98 formalin‑fixed, paraffin‑embedded (FFPE) tissues, including those from 82 thyroid cancer (TC) patients and 16 patients with benign nodules...
June 14, 2018: Oncology Reports
Shu-Fu Lin, Jen-Der Lin, Chuen Hsueh, Ting-Chao Chou, Richard J Wong
Activation of cyclin-dependent kinase activity is frequently observed in many human cancers; therefore, cyclin-dependent kinases that promote cell cycle transition and cell proliferation may be potential targets in the treatment of malignancy. The therapeutic effects of roniciclib, a cyclin-dependent kinase inhibitor for papillary and follicular thyroid cancer (designated as well-differentiated thyroid cancer), were investigated in this study. Roniciclib inhibited cell proliferation in two papillary and two follicular thyroid cancer cell lines in a dose-dependent manner...
June 12, 2018: Endocrine-related Cancer
Rajdee de Randamie, Gabriel Ángel Martos-Moreno, César Lumbreras, Maria Chueca, Sergio Donnay, Manuel Luque, Rita María Regojo, Marta Mendiola, David Hardisson, Jesús Argente, José C Moreno
BACKGROUND/AIMS: A genomic HABP2 variant was proposed to be responsible for familial nonmedullary thyroid carcinoma (FNMTC). However, its involvement has been questioned in subsequent studies. We aimed to identify genetic HABP2 mutations in a series of FNMTC patients and investigate their involvement in the disease. METHODS: HABP2 was sequenced from 6 index patients. Presence of the variants was investigated in all members of one family. Somatic BRAF and RAS "hotspot" mutations were investigated by the IdyllaTM BRAF Mutation Test and/or Sanger sequencing...
June 12, 2018: Hormone Research in Pædiatrics
Yi-Wen Hong, Jen-Der Lin, Ming-Chin Yu, Chih-Chieh Hsu, Yann-Sheng Lin
BACKGROUND: Cranial metastasis of thyroid cancer is rare. The aim of this study was to analyse the clinical characteristics, treatments and outcomes of thyroid cancer patients with cranial metastasis and to identify the associated prognostic factors. MATERIALS AND METHODS: Between January 1977 and August 2017, a total of 4683 patients were histologically confirmed to have thyroid cancer. Among them, 25 patients (0.53%) were identified as having cranial metastases, and their medical records were reviewed...
July 2018: International Journal of Surgery
Danielle Huk, Amruta Ashtekar, Alexa Magner, Krista La Perle, Lawrence S Kirschner
BACKGROUND: Thyroid cancer is an emerging health problem in the United States and Worldwide. With incidence rates of thyroid cancer rapidly rising, the need to develop new treatment options is becoming a priority, and understanding the molecular mechanisms of this disease is crucial to furthering these efforts. Thyroid growth is driven by the TSH/cAMP/PKA signaling pathway, and we have previously shown that activation of PKA through genetic ablation of the regulatory subunit Prkar1a (Prkar1a KO) is sufficient to cause follicular thyroid cancer in mouse models...
June 8, 2018: Thyroid: Official Journal of the American Thyroid Association
Christian Mirian, Christian Grønhøj, David Hebbelstrup Jensen, Kathrine Kronberg Jakobsen, Kirstine Karnov, Jakob Schmidt Jensen, Christoffer Holst Hahn, Tina Agander Klitmøller, Jens Bentzen, Christian von Buchwald
BACKGROUND: Thyroid cancer incidence has been reported to be increasing since the 1970 s. The aim of this study was to investigate the change in incidence and survival from 1980 to 2014 in Denmark. METHODS: We identified patients registered with thyroid cancer in the period 1980-2014. We evaluated the age-adjusted incidence rate (AAIR) and the average annual percentage change (AAPC), constructed age-period-cohort models (APCs), and evaluated relative survival (RS)...
May 28, 2018: Cancer Epidemiology
Evert F S van Velsen, Merel Stegenga, Folkert J van Kemenade, Boen Kam, Tessa Malaika van Ginhoven, W Edward Visser, Robin Peeters
Background Recently, the 8th edition of the AJCC/TNM staging system for differentiated thyroid cancer (DTC) was published. Studies evaluating this new edition so far only comprised patients with papillary thyroid cancer (PTC) or made no distinction between PTC and follicular thyroid cancer (FTC). Therefore, we evaluated the prognostic value of the AJCC/TNM 8th edition in a European population with DTC focusing on potential differences between PTC and FTC. Methods We retrospectively studied adult patients with DTC who were diagnosed and/or treated at a Dutch university hospital between January 2002 and April 2016...
May 31, 2018: Thyroid: Official Journal of the American Thyroid Association
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