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Follicular thyroid cancer

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https://www.readbyqxmd.com/read/28537891/multiplex-pcr-approach-to-simultaneously-identify-several-mutations-in-fine-needle-cytology-thyroid-samples
#1
Emilia Vuttariello, Marco Borra, Elvira Mauriello, Celeste Calise, Barbara D'Andrea, Anna Capiluongo, Franco Fulciniti, Anna Cipolletta, Mario Monaco, Luciano Pezzullo, Gennaro Chiappetta
The most frequent initial manifestation of thyroid cancer is the appearance of a nodule. More than 20% of the general population has a palpable thyroid nodule and the percentage rises to 70% based on ultrasound identification. In 95% of cases the nodule is simply a hyperplastic or benign lesion. The most reliable diagnostic test for thyroid nodules is fine needle aspiration (FNA), but cytological discrimination between malignant and benign follicular neoplasms remains difficult. Cytological analysis is now, almost routinely, being combined with molecular genetics to enable the pathologist to make a more objective diagnosis...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28534687/role-of-molecular-markers-in-thyroid-nodule-management-then-and-now
#2
Yuri E Nikiforov
OBJECTIVE: To describe the evolution and clinical utility of molecular testing for thyroid nodules and cancer achieved over the last two decades. METHODS: Scientific reports on thyroid cancer genetics and molecular diagnostics in thyroid nodules. RESULTS: Over the last two decades, our understanding of the genetic mechanisms of thyroid cancer has dramatically expanded, such that most thyroid cancers now have known gene driver events. This knowledge provides the basis for establishing and further improving molecular tests for thyroid nodules and cancer and for the introduction of new entities such as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)...
May 23, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28529619/effects-of-prolonged-exposure-to-low-dose-metformin-in-thyroid-cancer-cell-lines
#3
Safar Kheder, Karen Sisley, Sirwan Hadad, Sabapathy P Balasubramanian
Background: Thyroid cancer is generally associated with an excellent prognosis, but there is significant long-term morbidity with standard treatment. Some sub-types however have a poor prognosis. Metformin, an oral anti-diabetic drug is shown to have anti-cancer effects in several types of cancer (breast, lung and ovarian cancer). The proposed mechanisms include activation of the Adenosine Mono-phosphate-activated Protein Kinase (AMPK) pathway and inhibition of the mTOR pathway (which promotes growth and proliferation)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28523362/transoral-endoscopic-thyroidectomy-our-initial-experience-using-a-new-endoscopic-technique
#4
Jun-Ook Park, Dong-Il Sun
BACKGROUND: A transoral approach has been experimentally introduced to the field of thyroid surgery and several groups in Asia have recently used the technique to treat patients. We performed transoral endoscopic thyroidectomies on patients with thyroid cancer or a benign tumor. METHODS: We reviewed the medical records of patients who underwent transoral endoscopic thyroid surgery between July 2016 and January 2017. A midline incision was made in the vestibule, and a 10 mm cannula was placed; then, the working space was widened by insufflating CO2 at a pressure of 5-6 mmHg...
May 18, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28507620/expression-of-e-cadherin-beta-catenin-in-epithelial-carcinomas-of-the-thyroid-gland
#5
Koni Ivanova, Julian Ananiev, Elina Aleksandrova, Maria Magdalena Ignatova, Maya Gulubova
BACKGROUND: The aberrant activation of Wnt signalling pathway may be a common denominator for the development of thyroid tumorigenesis. It was announced that the loss of E-cadherin rather than β-catenin mutation represents a crucial event in determining the degree of differentiation of thyroid carcinomas. AIM: The aim of the study was to evaluate the expression of E-cadherin and β-catenin in the thyroid cancer tissue and to correlate these data with some histological and clinical parameters of the tumours...
April 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28506415/risk-of-malignancy-in-thyroid-nodules-classified-as-tir-3a-what-therapy
#6
Fabio Medas, Enrico Erdas, Luca Gordini, Giovanni Conzo, Claudio Gambardella, Gian Luigi Canu, Giuseppe Pisano, Angelo Nicolosi, Pietro Giorgio Calò
BACKGROUND: The aim of the present study was to assess the clinical applicability of the TIR3A category in managing thyroid nodules, to examine the malignancy rates of TIR 3A and TIR 3B nodules, and to suggest management guidelines for these nodules. MATERIALS AND METHODS: Thyroid cytologies performed in patients referred to our Department between January 2014 and August 2016 were classified according to the guidelines published by the SIAPEC. 102 cases were included in this retrospective study and were divided into two groups: 19 TIR3A were included in group A and 83 TIR3B in group B...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28506051/-a-case-of-thyroid-like-follicular-carcinoma-of-the-kidney
#7
Katsuhiro Ito, Hiromitsu Negoro, Masashi Kubota, Hideaki Takada, Toshihiro Magaribuchi, Atsuro Sawada, Shusuke Akamatsu, Takashi Kobayashi, Naoki Terada, Toshinari Yamasaki, Takahiro Inoue, Tomomi Kamba, Yuki Teramoto, Osamu Ogawa
A 51-year-oldwoman with a right renal mass was referredto our hospital. Computedtomographic (CT) scan demonstrated a 30 mm-diameter renal mass with delayed enhancement. She underwent a robotassistedlaparoscopic right partial nephrectomy. The pathological examination showedthat tumor cells with eosinophilic, clear cytoplasm formedtubules of various sizes containing colloid-like material, which resembled the findings of thyroidfollicular carcinoma. The tumor was immunoreactive for vimentin andcytokeratin (CK) 7, whereas it lackedreactivity for thyroidtranscription factor-1 (TTF-1) or thyroglobulin...
April 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28493027/clinicopathological-characteristics-of-thyroid-cancer-in-the-federal-state-of-salzburg
#8
Gundula Rendl, Margarida Rodrigues, Gregor Schweighofer-Zwink, Josef Hutter, Anton Hittmair, Barbara Zellinger, Cornelia Hauser-Kronberger, Christian Pirich
OBJECTIVE: The aim of our investigation was to evaluate the clinicopathological characteristics and mutation patterns in newly diagnosed cases of thyroid cancer in the federal state of Salzburg, Austria, in the year 2013. METHODS: The medical records of all patients newly diagnosed with thyroid cancer in 2013 in the federal state of Salzburg were retrospectively reviewed. The clinicopathological characteristics and mutations of thyroid cancers were analyzed. RESULTS: 63 patients (mean age: 51...
May 10, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28490032/haplotype-based-analysis-of-xrcc3-gene-polymorphisms-in-thyroid-cancer
#9
Romana Sarwar, Ishrat Mahjabeen, Kashif Bashir, Soma Saeed, Mahmood Akhtar Kayani
BACKGROUND/AIMS: In mammalian cells, XRCC3 plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to thyroid cancer. In this study, we used a haplotype-based approach to investigate whether 5 selected SNPs i.e. rs1799796, rs1799794, rs861539, rs709399 and rs861530 of XRCC3 gene are associated with thyroid cancer risk in 456 cancer patients and 400 cancer-free controls...
May 10, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28487771/noninvasive-encapsulated-follicular-variant-of-papillary-thyroid-cancer-clinical-lessons-from-a-community-based-endocrine-surgical-practice
#10
Allan Golding, Dana Shively, David N Bimston, R Mack Harrell
Objective. Retrospective studies have found that noninvasive encapsulated follicular variant of papillary thyroid cancer (EFVPTC) exhibits highly indolent clinical behavior. We studied the clinical features of our patients with noninvasive EFVPTC tumors culled from a community endocrine surgical practice registry over the past four years. Methods. We interrogated the Memorial Center for Integrative Endocrine Surgery (MCIES) Registry for all recorded encapsulated follicular variant of papillary cancer pathologic diagnoses...
2017: International Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28486057/low-rate-of-niftp-in-asian-practice
#11
Andrey Bychkov, Mitsuyoshi Hirokawa, Chan Kwon Jung, Zhiyan Liu, Yun Zhu, Soon Won Hong, Shinya Satoh, Chiung-Ru Lai, Lien Huynh, Kennichi Kakudo
Reclassification of non-invasive encapsulated follicular variant of papillary thyroid carcinoma (EFV-PTC) into non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has significant impact for patients and clinicians. It was estimated that this reclassification could potentially affect more than 45,000 patients worldwide annually (around 20% of thyroid carcinoma), who will not be labeled as having cancer. Our experience from Asian grounds indicates that NIFTP is extremely rare in local practice...
May 9, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28476040/efficacy-of-a-hsp90-inhibitor-ganetespib-in-preclinical-thyroid-cancer-models
#12
Shu-Fu Lin, Jen-Der Lin, Chuen Hsueh, Ting-Chao Chou, Chun-Nan Yeh, Ming-Huang Chen, Richard J Wong
Heat shock protein 90 is a molecular chaperon that maintains the correct folding and function of multiple client proteins. The inhibition of heat shock protein 90, which leads to the simultaneous degradation of multiple proteins involved in oncogenic signaling pathways, has revealed an innovative strategy to treat a variety of cancer types. We evaluated the therapeutic effects of ganetespib, a heat shock protein 90 inhibitor, in treating thyroid cancer. Ganetespib effectively inhibited cell proliferation in a dose-dependent manner in eight cell lines originating from four major histologic types of thyroid cancer (papillary, follicular, anaplastic and medullary)...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28474313/expression-of-hypoxia-associated-protein-hif-1%C3%AE-in-follicular-thyroid-cancer-is-associated-with-distant-metastasis
#13
Aumayr Klaus, Osmen Fathi, Traub-Weidinger Tatjana, Niederle Bruno, Koperek Oskar
Follicular thyroid carcinomas (FTCs) are the second most common malignant neoplasia of the thyroid and in general its prognosis is quite favorable. However, the occurrence of metastases or non-responsiveness to radioiodine therapy worsens the prognosis considerably. We evaluated immunohistochemically the expression of hypoxia-associated proteins by hypoxia-induced factor 1α (HIF-1α), the stroma-remodeling marker Tenascin C, as well as markers for the epithelial-mesenchymal transition (EMT), namely E-cadherin and slug in a series of 59 sporadic FTCs...
May 4, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28473950/unusual-metastasis-of-papillary-thyroid-cancer-to-the-thoracic-spine-a-case-report-new-surgical-management-proposal-and-review-of-the-literature
#14
Ariel Takayanagi, Omid Hariri, Hammad Ghanchi, Dan E Miulli, Javed Siddiqi, Frank Vrionis, Farbod Asgarzadie
Papillary thyroid carcinoma (PTC) is significantly more common than follicular thyroid carcinoma (FTC), yet FTC has a much higher tendency to metastasize to the spinal column. We present a rare case of a metastatic thoracic spinal column lesion originating from the PTC. Thyroid carcinoma is known to be highly vascular with a significant tendency to hemorrhage during surgical resection. This increased tendency to hemorrhage leads to unanticipated intraoperative risks when the type of cancer is not diagnosed before surgical resection...
April 3, 2017: Curēus
https://www.readbyqxmd.com/read/28471115/clinical-characteristics-and-treatment-of-thyroid-cancer-in-children-and-adolescents-a-retrospective-analysis-of-83-patients
#15
Xiao-Chun Mao, Wen-Qiao Yu, Jin-Biao Shang, Ke-Jing Wang
OBJECTIVE: To study the clinical characteristics, treatment, and prognosis of thyroid cancer in children and adolescents. METHODS: We performed a retrospective analysis of clinical data from 83 cases of thyroid cancer in children and adolescents from January 1990 to December 2010. We compared extra-thyroid extension, lymph node metastasis, distant metastasis, and prognosis between pediatric patients ≤12 years of age (27 cases) and those >12 years of age (56 cases)...
May 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28459034/lack-of-association-of-b-type-raf-kinase-v600e-mutation-with-high-risk-tumor-features-and-adverse-outcome-in-conventional-and-follicular-variants-of-papillary-thyroid-carcinoma
#16
C Gopalakrishnan Nair, Misha Babu, Lalitha Biswas, Pradeep Jacob, Riju Menon, A K Revathy, Krishnanunni Nair
INTRODUCTION: Somatic B-type Raf kinase (BRAF) V600E mutation in exon 15 was frequently found in high frequencies associated with papillary thyroid cancer (PTC). The phenotype of these cancers expressed aggressive clinical and pathological features. The present study aimed to assess the prevalence of BRAF V600E mutation among conventional and follicular variants of PTC and its association with aggressive tumor factors and outcome. STUDY DESIGN: Patients who were operated and received further treatment for PTC during 2012 were included in the study...
March 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28454345/high-il-17-expression-is-associated-with-an-unfavorable-prognosis-in-thyroid-cancer
#17
Denise Faria Galano Carvalho, Bruna Riedo Zanetti, Lydianne Miranda, Marcela Kazue Hassumi-Fukasawa, Fabiana Miranda-Camargo, Janaína Cristiana Oliveira Crispim, Edson Garcia Soares
Previous studies have indicated that cancer may be promoted and/or exacerbated by inflammation and infection. The cytokines produced by activated innate immune cells that stimulate tumor growth and progression are considered as important components in this process. The interleukin (IL)-23/T helper (Th)17 axis, which exerts marked pro-inflammatory effects, has emerged as an important mediator in inflammation-associated cancer. Increasing clinical evidence indicates that Th17 may promote or inhibit tumor progression, however, the function of Th17 in the pathogenesis of benign and malignant thyroid neoplasms remains unclear...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28446057/comparison-of-survival-outcomes-following-postsurgical-radioactive-iodine-versus-external-beam-radiation-in-stage-iv-differentiated-thyroid-carcinoma
#18
Zao Yang, Jose Flores, Sanford Katz, Cherie-Ann Nathan, Vikas Mehta
BACKGROUND: There is a lack of well-powered data regarding outcomes in stage IV differentiated thyroid carcinoma (DTC) treated with postsurgical radiation. The objective of this study was to examine survival in patients with stage IV papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) who received radioactive iodine (RAI), external beam radiation therapy (EBRT), or neither following surgery. METHODS: In this retrospective cohort study, data collected from the National Cancer Data Base (NCDB) yielded 11,832 patients with stage IV DTC who underwent primary surgical treatment between 2002 and 2012...
May 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28443243/association-between-hashimoto-s-thyroiditis-and-thyroid-cancer-in-64-628-patients
#19
Christina Resende de Paiva, Christian Grønhøj, Ulla Feldt-Rasmussen, Christian von Buchwald
BACKGROUND: The incidence of thyroid cancer (TC) is increasing although explanatory causes are lacking. A link between cancer and inflammation is well documented but unclear for autoimmune thyroid diseases and TC. We aimed to systematically review the association between Hashimoto's thyroiditis (HT) and papillary, follicular, medullary, anaplastic thyroid carcinoma, and thyroid lymphoma (TL). METHODS: PubMed, OVID Medline, Google Scholar, and the Cochrane Library were searched from 1955 to 2016...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28439496/bethesda-system-for-reporting-thyroid-cytopathology-a-three-year-study-at-a-tertiary-care-referral-center-in-saudi-arabia
#20
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Aljuboury Muna, Alkharashi Eyad, Abdullah Al Ghamdi, Khalid Al Hajeri, Mohammed A Thabet, Rim Braham
AIM: To stratify the malignancy risks in thyroid nodules in a tertiary care referral center using the Bethesda system. METHODS: From January, 2012 to December, 2014, a retrospective analysis was performed among 1188 patients (15-90 years) who had 1433 thyroid nodules and fine-needle aspiration at Prince Sultan Military Medical City, Saudi Arabia. All thyroid cyto-pathological slides and ultra sound reports were reviewed and classified according to the Bethesda System for Reporting Thyroid Cytopathology...
April 10, 2017: World Journal of Clinical Oncology
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