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Follicular thyroid cancer

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https://www.readbyqxmd.com/read/28943926/combination-of-galectin-3-ck19-and-hbme-1-immunostaining-improves-the-diagnosis-of-thyroid-cancer
#1
Vanessa Arcolia, Fabrice Journe, Florence Renaud, Emmanuelle Leteurtre, Hans-Joachim Gabius, Myriam Remmelink, Sven Saussez
Currently, fine-needle aspiration is the most frequently used pre-operative technique for diagnosis of malignant thyroid tumors, however, pathologists are unable to reach efficient and accurate differential diagnoses between benign and malignant thyroid nodules. To aid in resolving this issue, immunohistochemistry for galectins (gal)-1, -3, -7, -8, cytokeratin 19 (CK19), Hector Battifora Mesothelial Epitope-1 (HBME-1) and thyroid peroxidase (TPO) was performed on two tissue microarrays composed of 66 follicular adenomas (FA) and 66 papillary carcinomas (PC)...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943919/braf-v600e-mutation-is-not-associated-with-central-lymph-node-metastasis-in-all-patients-with-papillary-thyroid-cancer-different-histological-subtypes-and-preoperative-lymph-node-status-should-be-taken-into-account
#2
Si-Yang Dong, Rui-Chao Zeng, Lang-Ping Jin, Fan Yang, Xiang-Jian Zhang, Zhi-Han Yao, Xiao-Hua Zhang, Ou-Chen Wang
The association between central lymph node metastasis (LNM) and risk factors, including the presence of the BRAF mutation, BRAF(V600E), in patients with papillary thyroid cancer (PTC) requires further investigation. A potent risk factor that can indicate LNM in different histological subtypes of PTC and in different preoperative central lymph node statuses also requires further research. A total of 287 patients with PTC who accepted thyroidectomy were included in the present study. Clinicopathological data of these patients were reviewed to examine the risk factors for central LNM through univariate and multivariate analyses...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28941185/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-implications-for-the-risk-of-malignancy-rom-in-the-bethesda-system-for-reporting-thyroid-cytopathology-tbsrtc
#3
Haijun Zhou, Zubair W Baloch, Ritu Nayar, Tommaso Bizzarro, Guido Fadda, Deepti Adhikari-Guragain, Joseph Hatem, Luigi M Larocca, Julia Samolczyk, Jamie Slade, Esther Diana Rossi
BACKGROUND: The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) affects the risk of malignancy (ROM) mostly in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories. In this multi-institutional, retrospective study, the authors investigated variations in the impact of an NIFTP diagnosis on the associated ROM for each TBSRTC category with an emphasis on the influence of pathologist and institutional diagnostic thresholds on the ROM...
September 20, 2017: Cancer
https://www.readbyqxmd.com/read/28938489/prognostic-classifier-based-on-genome-wide-dna-methylation-profiling-in-well-differentiated-thyroid-tumors
#4
Mariana Bisarro Dos Reis, Mateus Camargo Barros-Filho, Fábio Albuquerque Marchi, Caroline Moraes Beltrami, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto
Context: Even though the majority of well-differentiated thyroid cancer (WDTC) is indolent, a number of cases display an aggressive behavior. Cumulative evidences have suggested that the deregulation of DNA methylation has the potential to point out molecular markers associated with worse prognosis. Objective: To identify a prognostic epigenetic signature in thyroid cancer. Design: Genome-wide DNA methylation assays (450k platform, Illumina) were performed in a cohort of 50 non-neoplastic thyroid tissues (NT), 17 benign thyroid lesions (BTL) and 74 thyroid carcinomas (60 papillary, 8 follicular, 2 Hürthle cell, 1 poorly differentiated and 3 anaplastic)...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28920557/automated-microspect-microct-image-analysis-of-the-mouse-thyroid-gland
#5
Peng Cheng, Brynn Hollingsworth, Daniel Scarberry, Daniel Hueng-Yuan Shen, Kimerly Powell, Sean C Smart, John Beech, Xiaochao Sheng, Lawrence S Kirschner, Chia-Hsiang Menq, Sissy M Jhiang
<b>Background:</b> The ability of thyroid follicular cells to take up iodine enables the use of radioactive iodine (RAI) for imaging and targeted killing of RAI-avid thyroid cancer following thyroidectomy. To facilitate identifying novel strategies to improve <sup>131</sup>I therapeutic efficacy for patients with RAI refractory disease, it is desired to optimize image acquisition and analysis for preclinical mouse models of thyroid cancer. <b>Methods:</b> A customized mouse cradle was designed and used for microSPECT/CT image acquisition at 1 hour (t1) and 24 hours (t24) post-injection of <sup>123</sup>I, which mainly reflect RAI influx/efflux equilibrium and RAI retention in the thyroid, respectively...
September 16, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28919092/cervical-soft-tissue-recurrence-of-differentiated-thyroid-carcinoma-after-thyroidectomy-indicates-a-poor-prognosis
#6
Luying Gao, Yuxin Jiang, Zhiyong Liang, Lei Zhang, Xinxin Mao, Xiao Yang, Ying Wang, Jingzhu Xu, Ruyu Liu, Shenling Zhu, Ruina Zhao, Xingjian Lai, Xiaoyan Zhang, Bo Zhang
BACKGROUND: We investigated cervical soft tissue recurrence of differentiated thyroid carcinoma (DTC) after thyroidectomy, and these lesions exhibited no evidence that they were lymph nodes (LNs). METHODS: Between January 2012 and April 2016, consecutive 6308 patients underwent thyroid surgery for DTC at our center. Among them, we encountered 21 patients with recurrent cervical soft tissue lesions, none of whom had previously undergone fine needle aspiration biopsy (FNAB)...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28914983/suggesting-the-cytologic-diagnosis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-a-retrospective-analysis-of-atypical-and-suspicious-nodules
#7
Kyle C Strickland, Brooke E Howitt, Justine A Barletta, Edmund S Cibas, Jeffrey F Krane
BACKGROUND: The term "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) has replaced a subset of follicular variant of papillary thyroid carcinoma due to the indolent behavior of such tumors. NIFTPs are most often classified in an "indeterminate" diagnostic category. In the current study, the authors sought to identify cytologic features helpful in distinguishing NIFTP from other entities in these categories, particularly benign nodules. METHODS: The authors retrospectively evaluated a consecutive cohort of 130 thyroid fine-needle aspiration (FNA) specimens with an indeterminate diagnosis and available histopathologic follow-up...
September 15, 2017: Cancer
https://www.readbyqxmd.com/read/28902465/a-modified-reporting-approach-for-thyroid-fna-in-the-niftp-era-a-1-year-institutional-experience
#8
Jeffrey K Mito, Erik K Alexander, Trevor E Angell, Justine A Barletta, Matthew A Nehs, Edmund S Cibas, Jeffrey F Krane
BACKGROUND: The reclassification of noninvasive follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) has created diagnostic and management issues for thyroid fine-needle aspiration (FNA). In response to these challenges, the authors' laboratory adopted a NIFTP policy including 1) stringent criteria (requiring pseudo-inclusions, papillae, and/or psammoma bodies) for a malignant diagnosis of papillary carcinoma to limit false-positive results due to NIFTP and 2) the use of explanatory notes in cases with cytomorphologic features suggestive of possible NIFTP to encourage lobectomy over thyroidectomy...
September 13, 2017: Cancer
https://www.readbyqxmd.com/read/28902351/anoctamin5-regulates-cell-migration-and-invasion-in-thyroid-cancer
#9
Zhengyan Chang, Chunmiao Cai, Dongyan Han, Yaohui Gao, Qianyu Li, Lijin Feng, Wei Zhang, Jiayi Zheng, Jiaoying Jin, Huizhen Zhang, Qing Wei
Anoctamin/TMEM16 family members have recently been identified as novel calcium-activated chloride channels, and dysregulation of many family members participates in tumorigenesis and progression. However, the exact role of anoctamin5 (ANO5), one member of this family, in thyroid cancer is still not clarified. In this study, we firstly found that the expression levels of ANO5 was significantly downregulated in thyroid cancer compared to adjacent normal tissue by mining the public GEO database. Subsequently, we further demonstrated that the expression levels of ANO5 was significantly downregulated in 69...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28898488/prevention-of-total-thyroidectomy-in-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-based-on-combined-interpretation-of-ultrasonographic-and-cytopathologic-results
#10
Sung-Hye You, Kyu Eun Lee, Roh-Eul Yoo, Hye Jeong Choi, Kyeong Cheon Jung, Jae-Kyung Won, Koung Mi Kang, Tae Jin Yoon, Seung Hong Choi, Chul-Ho Sohn, Ji-Hoon Kim
OBJECTIVE: To explore the potential preoperative ultrasonography (US) and cytopathological features to avoid total thyroidectomy in NIFTP CONTEXT: Recently, it has been proposed that that non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) be classified as tumors, rather than cancer. PATIENTS: A total of 142 surgically proven follicular variant papillary thyroid carcinomas (FVPTCs; 45 NIFTP, 97 non-NIFTP; mean size: 20.4±11.0 mm, range: 10...
September 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28883260/a-case-of-metastatic-follicular-thyroid-carcinoma-complicated-with-graves-disease-after-total-thyroidectomy
#11
Mariko Aoyama, Hiromitsu Takizawa, Mitsuhiro Tsuboi, Yasushi Nakagawa, Akira Tangoku
Thyroid cancer and Graves' disease may present simultaneously in one patient. The incidence of the development of hyperthyroidism from metastatic differentiated thyroid carcinoma is rare. We herein report a case of metastatic follicular carcinoma complicated with Graves' disease after total thyroidectomy. A 57-year-old woman underwent right hemithyroidectomy for follicular carcinoma. Metastatic lesions appeared in the lungs and skull two years after the first surgery, and remnant thyroidectomy was performed for radioactive iodine-131 (RAI) therapy, during which the TSH receptor antibody (TRAb) was found to be negative...
September 5, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28880059/evaluation-of-somatic-genomic-imbalances-in-thyroid-carcinomas-of-follicular-origin-by-cgh-based-approaches
#12
Federica Baldan, Catia Mio, Lorenzo Allegri, Nadia Passon, Saverio M Lepore, Diego Russo, Giuseppe Damante
INTRODUCTION: Application of distinct technologies of cancer genome analysis has provided important information for the molecular characterization of several human neoplasia, including follicular cell-derived thyroid carcinoma. Among them, comparative genomic hybridization (CGH)-based procedures have been extensively applied to evaluate genomic imbalances present in these tumours, obtaining data leading to an increase in the understanding of their complexity and diversity. EVIDENCE ACQUISITION: In this review, after a brief overview of the most commonly used CGH-based technichs, we will describe the major results deriving from the most influential studies in the literature which used this approach to investigate the genomic aberrations of thyroid cancer cells...
September 7, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28879559/yonsei-experience-of-5000-gasless-transaxillary-robotic-thyroidectomies
#13
Min Jhi Kim, Kee-Hyun Nam, Seul Gi Lee, Jung Bum Choi, Tae Hyung Kim, Cho Rok Lee, Jandee Lee, Sang-Wook Kang, Jong Ju Jeong, Woong Youn Chung
BACKGROUND: Since the use of robot systems in thyroid surgery was introduced in 2007, we have advanced a novel method of robotic thyroidectomy (RT) using a gasless transaxillary approach (TAA). We report our experience with this technique and detail the surgical outcome of 5000 robotic thyroidectomies. METHODS: From October 2007 to May 2016, we successfully performed 5000 robotic thyroidectomies using a gasless TAA at the Department of Surgery, Yonsei University Health System...
September 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28876578/thyroid-cancer-consequences-of-iodine-deficiency-a-persisting-worldwide-problem-characteristics-in-different-populations-portugal-and-south-africa
#14
J E Santos
BACKGROUND: Iodine deficiency (ID) still affects over two billion people worldwide (266 million school aged children). Pathology patterns in ID include: increase in thyroid cancer, higher percentages of follicular and anaplastic cancers and inversion of the papillary/follicular thyroid cancer frequency ratio. China succeeded in eliminating ID through legislation introduced in 1987 aimed at availability of iodized salt countrywide and South Africa through legislation introduced in 1995...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28864536/changes-in-the-clinicopathological-characteristics-and-genetic-alterations-of-follicular-thyroid-cancer
#15
Young Shin Song, Jung Ah Lim, Hye Sook Min, Min Joo Kim, Hoonsung Choi, Sun Wook Cho, Jae Hoon Moon, Ka Hee Yi, Do Joon Park, Bo Youn Cho, Young Joo Park
OBJECTIVE: Changes in the clinicopathological characteristics and genetic alterations of follicular thyroid cancer (FTC) over time have not been reported. Moreover, the prognostic effects of RAS and TERT promoter mutations in FTC have not been clearly elucidated. We investigated changes in the clinicopathological characteristics of patients with FTC over four decades, as well as the clinical significance of genetic mutations of FTC. DESIGN AND METHODS: This retrospective study included 690 patients with FTC who underwent thyroidectomy between 1973 and 2015 at the Seoul National University Hospital...
September 1, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28859553/thyroid-nodule-diagnostic-markers-in-the-face-of-the-new-diagnosis-nift-p-time-for-a-reset
#16
Zeyad T Sahli, Christopher B Umbricht, Eric B Schneider, Martha A Zeiger
Current thyroid molecular tests are specifically designed for the differential diagnosis of nodules with indeterminate or suspicious fine needle aspiration (FNA) cytology. However, their clinical validity faces challenges from both variation among institutions in cancer prevalence and, most recently, the new category of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFT-P). The latter diagnosis was previously classified as malignant. Relevant to this, all molecular panels on the market today were originally tested and validated within the context of these entities being considered malignant...
August 31, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28858122/higher-body-weight-and-distant-metastasis-are-associated-with-higher-radiation-exposure-to-the-household-environment-from-patients-with-thyroid-cancer-after-radioactive-iodine-therapy
#17
Sheng-Fong Kuo, Tsung-Ying Ho, Miaw-Jene Liou, Kun-Ju Lin, Ru-Chin Cheng, Sheng-Chieh Chan, Bie-Yui Huang, Soh-Ching Ng, Feng-Hsuan Liu, Hung-Yu Chang, Sheng-Hwu Hsieh, Kun-Chun Chiang, Huang-Yang Chen, Ta-You Lo, Chih-Lang Lin, Jen-Der Lin
There were insufficient data regarding radiation exposure to the household environment from patients with thyroid cancer who received radioactive iodine (RAI) therapy in Asia; we therefore performed the present study at the Chang Gung Memorial Hospital in Keelung, Taiwan.Patients with papillary or follicular thyroid cancer who received 3.7 GBq (100 mCi) RAI were enrolled in this prospective hospital-based study. The enrolled patients were asked to place a thermoluminescent dosimeter in the living room, bedroom, and bathroom of their houses for 4 weeks to measure radiation exposure to the household environment...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28855436/effects-of-sorafenib-and-an-adenylyl-cyclase-activator-on-in-vitro-growth-of-well-differentiated-thyroid-cancer-cells
#18
Aya Sawa, Tomohiro Chiba, Jun Ishii, Hiroyuki Yamamoto, Hisato Hara, Hiroshi Kamma
Well-differentiated thyroid carcinomas have driver mutations involving growth factor receptor-tyrosine kinases (RTKs) or their intracellular signaling pathway, that is, the mitogen-activated protein kinase (MAPK) pathway. Sorafenib is a multikinase inhibitor of RTKs and the MAPK pathway and has recently been used for the treatment of unresectable well-differentiated thyroid carcinoma. In normal thyroid follicular cells, stimulation of the thyroid-stimulating hormone (TSH) receptor activates the cyclic adenosine monophosphate (cAMP) pathway and promotes cell growth as well as hormonal secretion...
August 31, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28851673/mitochondrial-dna-haplogroup-k-as-a-contributor-to-protection-against-thyroid-cancer-in-a-population-from-southeast-europe
#19
Relu Cocoş, Sorina Schipor, Corin Badiu, Florina Raicu
We aimed to analyze the contribution of mitochondrial DNA (mtDNA) haplogroups of the mtDNA control region to thyroid cancer risk in a population from southeastern Europe consisting of 235 thyroid tumor patients, including 114 patients with thyroid follicular adenoma, 121 patients with papillary thyroid carcinoma, and 419 healthy controls. Binary logistic regression with adjustment for age and gender revealed that mtDNA haplogroup K was significantly associated with a protective role for thyroid cancer in the combined tumor group versus controls...
August 26, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28844117/well-differentiated-thyroid-cancer-neovasculature-expresses-prostate-specific-membrane-antigen-a-possible-novel-therapeutic-target
#20
Maureen Moore, Suraj Panjwani, Rashmi Mathew, Michael Crowley, Yi-Fang Liu, Anna Aronova, Brendan Finnerty, Rasa Zarnegar, Thomas J Fahey, Theresa Scognamiglio
Prostate-specific membrane antigen (PSMA), a type II transmembrane glycoprotein receptor, is highly expressed in prostate cancer and in the tumor neovasculature of colon, breast, and adrenocortical tumors. Here, we analyzed PSMA expression in the neovasculature of various thyroid cancer subtypes and assessed whether PSMA expression is correlated with aggressive behavior. From a prospectively maintained database, we evaluated 91 samples from 68 patients, including 37 primary differentiated thyroid cancers (DTCs) [11 classic papillary (cPTC), 9 follicular-variant (FvPTC), 11 follicular (FTC), 6 radioactive iodine-refractory (RAIR)], 5 anaplastic (ATC) carcinomas, 9 distant and 12 lymph node metastases, 21 benign thyroid nodules, and 7 normal thyroid specimens...
August 26, 2017: Endocrine Pathology
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