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Follicular thyroid cancer

Mohsen Qutbi, Babak Shafeie, Mahasti Amoui, Faraj Tabeie, Zahra Azizmohammadi, Ali Mahmoud-Pashazadeh, Hamid Javadi, Majid Assadi, Isa Neshandar Asli
BACKGROUND: Because one of the major sites for metastasis of thyroid cancers is the lung, studying the pattern of pulmonary metastasis may provide useful information for the effective treatment of these patients. In this study, by assessing the metastasis pattern, we aimed to identify the factors that may affect prognosis and response to treatment in patients with differentiated thyroid carcinoma (DTC) with pulmonary metastasis. METHODS: This retrospective study included 75 patients with DTC with pulmonary metastasis who were referred to our nuclear medicine section over a period of 10 years...
October 18, 2016: Clinical Nuclear Medicine
Michele M Merten, M Regina Castro, Jun Zhang, Jolanta M Durski, Mabel Ryder
BACKGROUND: Cytologically defined indeterminate thyroid nodules are a diagnostic challenge. Surgical lobectomy remains gold standard for definitive diagnosis, however, 70-85% of nodules are ultimately benign. The primary objective of this study was to evaluate the negative predictive value (NPV) of F18-Fluorodeoxyglucose (FDG) positron emission computed tomography (PET/CT) in excluding cancer among cytologically indeterminate thyroid nodules within our institution using surgical pathology as a gold standard reference and to perform a systematic review of published prospective studies on the NPV of PET/CT in evaluating indeterminate thyroid nodules...
October 20, 2016: Thyroid: Official Journal of the American Thyroid Association
Monika Pietrowska, Hanna C Diehl, Grzegorz Mrukwa, Magdalena Kalinowska-Herok, Marta Gawin, Mykola Chekan, Julian Elm, Grzegorz Drazek, Anna Krawczyk, Dariusz Lange, Helmut E Meyer, Joanna Polanska, Corinna Henkel, Piotr Widlak
Determination of the specific type of thyroid cancer is crucial for the prognosis and selection of treatment of this malignancy. However, in some cases appropriate classification is not possible based on histopathological features only, and it might be supported by molecular biomarkers. Here we aimed to characterize molecular profiles of different thyroid malignancies using mass spectrometry imaging (MSI) which enables the direct annotation of molecular features with morphological pictures of an analyzed tissue...
October 17, 2016: Biochimica et Biophysica Acta
Shih-Ping Cheng, Po-Sheng Yang, Ming-Nan Chien, Ming-Jen Chen, Jie-Jen Lee, Chien-Liang Liu
BACKGROUND AND OBJECTIVES: The induction of tumor-associated carbohydrate antigen results from altered glycosylation in transformed cells. Globo H is a hexasaccharide glycosphingolipid overexpressed on malignancies of epithelial origin and has become an attractive vaccine target. We aimed to investigate the expression patterns and prognostic value of Globo H in thyroid neoplasms. METHODS: Globo H expression was examined by immunohistochemical analysis using commercial and in-house tissue microarrays...
October 18, 2016: Journal of Surgical Oncology
Friedhelm Raue, Karin Frank-Raue
Thyroid cancer is the most common endocrine malignancy. Differentiated thyroid cancer (DTC) with the two subtypes, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC), is the most frequent subtype of thyroid cancer; more rare subtypes are medullary thyroid cancer (MTC) and anaplastic thyroid cancer (ATC). The incidence of DTC has increased rapidly in recent years due to the more frequent use of imaging methods such as ultrasound of the neck and fine-needle aspiration (FNA) of thyroid nodules...
October 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Lin-Yun He, Wei-Wei Wang, Balde Alpha Ibrahima, Shuai Han, Zhou Li, Zhai Cai, Miao-Liang Chen, Bao-Zhu Chen, Hui-Shi Tan, Hai-Shan Zeng, Xiao-Li Dai, Min-Wei Zhou, Gang-Qing Zhang, Guo-Xin Li
Although the prognostic value of nodal metastases in differentiated thyroid cancer remains controversial, it is of interest to evaluate and understand the different characteristics of predictive outcomes.A multicenter retrospective study was conducted in 215 untreated patients with differentiated thyroid cancer from July 1997 to July 2015 in 4 medical centers of Guangdong Province. A total of 107 patients with nodal metastases (group A) were compared to 108 patients without metastases (group B). The 5-year disease-free survival (DFS), overall survival (OS), and postoperative complications in both groups were calculated...
October 2016: Medicine (Baltimore)
Beatriz G Cavalheiro, Leandro L Matos, Ana Kober N Leite, Marco Aurélio V Kulcsar, Claudio R Cernea, Lenine G Brandão
Objective: The aim of the present study was to describe the epidemiologic data, histological type, treatment and follow-up of the 811 patients treated for thyroid cancer in Instituto do Câncer do Estado de São Paulo (ICESP) over 5 years. Materials and methods: Retrospective analyses of electronic chart information. Results: There were 679 cases (83.7%) of papillary thyroid cancer, 61 (7.5%) of follicular carcinoma, 54 (6.7%) of medullary carcinoma, 11 (1...
October 10, 2016: Archives of Endocrinology and Metabolism
Umal Azmat, Kyle Porter, Leigha Senter, Matthew D Ringel, Fadi Nabhan
BACKGROUND: Thyroglobulin (Tg) measurement in patients with positive anti-thyroglobulin antibodies (anti-Tg Abs) is not reliable. Tg measurement using Liquid Chromatography Tandem Mass Spectrometry (LC/MS) may be useful in this setting Methods: This is a retrospective study with the objective to determine the accuracy of Tg-LC/MS in patients with thyroid cancer with anti-Tg Abs. We evaluated all patients with follicular cell-derived thyroid cancer (TC) who had thyroglobulin measured using LC/MS assay from 11/1/2013-11/7/2014...
October 13, 2016: Thyroid: Official Journal of the American Thyroid Association
Giovanni Tallini, R Michael Tuttle, Ronald A Ghossein
CONTEXT: The purpose of this review is to provide the historical context to recent developments in the classification of the follicular variant of papillary thyroid carcinoma (FVPTC), an entity that has long created significant controversy. The scope is to illustrate the evolution of the diagnostic criteria for papillary thyroid carcinoma, clarifying the role of molecular analysis, and the impact on patient management. EVIDENCE ACQUISITION: A PubMed search using the terms "follicular variant" and "papillary thyroid carcinoma" covering the years 1960-2016 was performed...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
Julietta V Rau, Valerio Graziani, Marco Fosca, Chiara Taffon, Massimiliano Rocchia, Pierfilippo Crucitti, Paolo Pozzilli, Andrea Onetti Muda, Marco Caricato, Anna Crescenzi
Recent investigations strongly suggest that Raman spectroscopy (RS) can be used as a clinical tool in cancer diagnosis to improve diagnostic accuracy. In this study, we evaluated the efficiency of Raman imaging microscopy to discriminate between healthy and neoplastic thyroid tissue, by analyzing main variants of Papillary Thyroid Carcinoma (PTC), the most common type of thyroid cancer. We performed Raman imaging of large tissue areas (from 100 × 100 μm(2) up to 1 × 1 mm(2)), collecting 38 maps containing about 9000 Raman spectra...
October 11, 2016: Scientific Reports
Tommaso Bizzarro, Maurizio Martini, Sara Capodimonti, Patrizia Straccia, Celestino Pio Lombardi, Alfredo Pontecorvi, Luigi Maria Larocca, Esther Diana Rossi
BACKGROUND: Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) represents a challenge for the diagnosis and management of thyroid carcinoma. Some authors have proposed histological criteria that are able to distinguish NIFTPs from invasive follicular variant of papillary thyroid carcinoma (I-FVPTC). Hence, NIFTPs may have repercussions in the diagnostic categories on fine-needle aspiration. In the current study, the authors evaluated the criteria for NIFTPs on liquid-based cytology samples...
October 2016: Cancer
Rame Miftari, Valdete Topçiu, Adem Nura, Valdete Haxhibeqiri
PURPOSE: Papillary carcinoma is the most frequent type of thyroid cancer and was considered the most benign of all thyroid carcinomas, with a low risk of distant metastases. However, there are some variants of papillary thyroid carcinoma that have affinity to spread in many organs, such as: lymph nodes, lungs and bones. AIM: The aim of this study was presentation of a case with papillary carcinoma of the thyroid gland, very persistent and resistant in treatment with I 131...
July 27, 2016: Medical Archives
Changyuan Wang, Xiaohua Chen, Xiaoyu Wei, Feng Chen, Yang Wang, Zhiyong Shen
BACKGROUND/OBJECTIVE: To investigate the factors associated with recurrence of differentiated thyroid cancer in children. We combined the clinical and pathological features to guide surgical treatment options, ensure efficacy, and reduce complications. METHODS: A prospective analysis of clinical data of 43 cases of pediatric differentiated thyroid cancer from March 2008 to June 2014 admitted in our department, including 38 cases of papillary cancers and five cases of follicular cancer; 40 cases were Stage I and three cases were Stage II (Union for International Cancer Control [UICC] Tumor Node Metastasis classification [TNM] staging)...
September 30, 2016: Asian Journal of Surgery
Sujay Kakarmath, Howard T Heller, Caroline A Alexander, Edmund S Cibas, Jeffrey F Krane, Justine A Barletta, Neal I Lindeman, Mary C Frates, Carol B Benson, Atul A Gawande, Nancy L Cho, Matthew Nehs, Francis D Moore, Ellen Marqusee, Mathew I Kim, P Reed Larsen, Norra Kwong, Trevor E Angell, Erik K Alexander
CONTEXT: Mutations in the BRAF and RAS oncogenes are responsible for most well-differentiated thyroid cancer. Yet, our clinical understanding of how BRAF-positive and RAS-positive thyroid cancers differ is incomplete. OBJECTIVE: We correlated clinical, radiographic, and pathologic findings from patients with thyroid cancer harboring a BRAF or RAS mutation. DESIGN: Prospective cohort study Setting: Academic, tertiary care hospital Patients: 101 consecutive patients with well-differentiated thyroid cancer Main Outcome Measure: We compared the clinical, sonographic, and pathologic characteristics of patients with BRAF-positive cancer to those with RAS-positive cancer...
September 30, 2016: Journal of Clinical Endocrinology and Metabolism
Rohit Ranganath, Manish A Shaha, Bin Xu, Jocelyn Migliacci, Ronald Ghossein, Ashok R Shaha
BACKGROUND: de Quervain's thyroiditis is an inflammatory condition of the thyroid mostly treated medically, rarely requiring surgical treatment. We intend to review the surgical experience with de Quervain's thyroiditis at a tertiary cancer center over a period of 22years. METHODS: A retrospective review of medical records from 1992 to 2014 at a tertiary cancer center was performed and all patients with a histopathological diagnosis of de Quervain's thyroiditis were included...
August 18, 2016: American Journal of Otolaryngology
Ana Lopez-Campistrous, Esther Ekpe Adewuyi, Matthew G K Benesch, Yi Man Ko, Raymond Lai, Aducio Thiesen, Jay Dewald, Peng Wang, Karen Chu, Sunita Ghosh, David C Williams, Larissa J Vos, David N Brindley, Todd P W McMullen
Dedifferentiation of follicular cells is a central event in resistance to radioactive iodine and patient mortality in papillary thyroid carcinoma (PTC). We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptional activity of thyroid transcription factor-1 (TTF1). PDGFRα activation dephosphorylates TTF1 consequently shifting the localization of this transcription factor from the nucleus to the cytoplasm. TTF1 is required for follicular cell development and disrupting its function abrogates thyroglobulin production and sodium iodide transport...
September 10, 2016: EBioMedicine
Andrej Vogrin, Hana Besic, Nikola Besic, Maja Marolt Music
BACKGROUND: Preoperative ultrasound (US) evaluation of central and lateral neck compartments is recommended for all patients undergoing a thyroidectomy for malignant or suspicious for malignancy cytologic or molecular findings. Our aim was to find out how frequent was recurrence in regional lymph nodes in patients with follicular or Hürthle cell neoplasm and usefulness of preoperative neck US investigation in patients with neoplasm. PATIENTS AND METHODS: Altogether 737 patients were surgically treated because of follicular or Hürthle cell neoplasms from 1995 to 2014 at our cancer comprehensive center, among them 207 patients (163 females, 44 males; mean age 52 years) had thyroid carcinoma...
September 1, 2016: Radiology and Oncology
B Evranos, S B Polat, H Baser, D Ozdemir, A Kilicarslan, A Yalcin, R Ersoy, B Cakir
BACKGROUND: A fine needle aspiration biopsy (FNAB) is the most valuable diagnostic procedure for pre-operative discrimination of benign and malignant nodules. The Bethesda System for Reporting Thyroid Cytopathology provides standardised reporting and cytomorphological criteria in aspiration smears. The aim of the present study was to determine malignancy rates in nodules with different cytology results and evaluate the diagnostic value of Bethesda for variants of papillary thyroid carcinoma (PTC)...
September 25, 2016: Cytopathology: Official Journal of the British Society for Clinical Cytology
Travis M Cotton, Jing Xin, John Sandyhya, Roy Lirov, Barbara S Miller, Mark S Cohen, Paul G Gauger, David T Hughes
BACKGROUND: The utility of frozen section (FS) for indeterminate thyroid nodules is controversial. In 2009, the Bethesda System for Reporting Thyroid Cytopathology was established to further subcategorize indeterminate fine-needle aspiration results (follicular lesions, FL) into Bethesda category 3 (BC3) and Bethesda category 4 (BC4). We hypothesize that FS will have less utility in the evaluation of BC3 lesions when compared to BC4. MATERIALS AND METHODS: A total of 479 patients who underwent thyroid lobectomy from January 2008 to July 2014 were retrospectively reviewed...
October 2016: Journal of Surgical Research
Pedro Weslley Rosario, Gabriela Franco Mourão, Mauricio Buzelin Nunes, Marcelo Saldanha Nunes, Maria Regina Calsolari
Recently, it was proposed that some papillary thyroid carcinomas (PTC) will no longer receive the name 'cancer' and start to be called 'noninvasive follicular thyroid neoplasm with papillary-like nuclear features' (NIFTP). Since this is a recent definition, little information is available about NIFTP. The objective of this study was to report the frequency, ultrasonographic appearance, cytology result, and long-term evolution of cases of NIFTP seen at our institution. We excluded tumors ≤ 1 cm. The sample consisted of 129 patients...
September 22, 2016: Endocrine-related Cancer
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