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Hypopharynx tumors metastasis neck

Mitsutoshi Ooishi, Atsushi Motegi, Mitsuhiko Kawashima, Satoko Arahira, Sadamoto Zenda, Naoki Nakamura, Takaki Ariji, Sunao Tokumaru, Minoru Sakuraba, Makoto Tahara, Ryuichi Hayashi, Tetsuo Akimoto
OBJECTIVE: To evaluate the feasibility of postoperative intensity-modulated radiotherapy for head and neck cancer by investigating the patterns of failure after this therapy. METHODS: A retrospective chart review was performed. RESULTS: Between March 2006 and December 2013, 122 consecutive patients with head and neck squamous cell carcinoma were treated by surgery followed by postoperative intensity-modulated radiotherapy. In regard to the site of the primary tumor, 59 (48%) patients had cancer of the oral cavity, 31 (26%) patients had cancer of the hypopharynx, 14 (11%) patients had cancer of the oropharynx, 10 (8%) patients had cancer of the larynx and 8 (7%) patients had cancer of unknown primary...
October 2016: Japanese Journal of Clinical Oncology
Naoya Murakami, Fumihiko Matsumoto, Seiichi Yoshimoto, Yoshinori Ito, Taisuke Mori, Takao Ueno, Keisuke Tuchida, Tairo Kashihara, Kazuma Kobayashi, Ken Harada, Mayuka Kitaguchi, Shuhei Sekii, Rei Umezawa, Kana Takahashi, Koji Inaba, Hiroshi Igaki, Jun Itami
BACKGROUND: The radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strategy is at a risk of loco-regional or distant metastasis. However, because patients are more closely checked than in Western countries by every 1 to 2 months intervals and it is supposed that regional recurrences are identified and salvage surgeries are performed more quickly...
March 7, 2016: BMC Cancer
Giulio Illuminati, Fabrice Schneider, Antonio Minni, Francesco G Calio, Giulia Pizzardi, Jean-Baptiste Ricco
OBJECTIVE: The management of patients with recurrent neck cancer invading the carotid artery is controversial. The purpose of this study was to evaluate overall survival rate, primary patency of vascular reconstructions, and quality-adjusted life-years (QALYs) after en bloc resection of the carotid artery and tumor with in-line polytetrafluoroethylene (PTFE) carotid grafting, followed by radiotherapy. METHODS: From 2000 to 2014, 31 consecutive patients with recurrent neck cancer invading the carotid artery underwent en bloc resection and simultaneous carotid artery reconstruction with a PTFE graft, which was associated in 18 cases with a myocutaneous flap...
May 2016: Journal of Vascular Surgery
Wenling Su, De'an Zhao
OBJECTIVE: To explore the clinical effect of the free radial forearm flap on repairing tissue defects and reconstructing functions after tumor resection.
 METHODS: From January, 2003 to December, 2011, 70 patients, including 43 squamous cell carcinomas of tongue, 12 buccal cancers, 5 carcinomas of the soft palate, 4 basal cell carcinomas of external nose, 3 lower lip cancers, 2 upper lip cancers, and 1 posterior wall of hypopharynx carcinoma, with the soft tissue defects in the head and neck underwent reconstructive operations with the free radial forearm flap after the malignant tumor resection...
October 2015: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Xin Lian, Wenyue Ji
OBJECTIVE: Study the clinical characteristics, treatment results and prognostic factors of hypopharyngeal carcinoma. MMETHOD: A retrospective analysis was performed of 97 hypopharyngeal cases that were treated in Department of Dtolaryngology of our hospital from January 2008 to December 2012. 93 cases of them are male patients, and 4 cases are female patients. The tumors are originated from pyriform sinus(75 cases), posterior pharyngeal wall (16 cases) and post-cricoid area (6 cases)...
March 2015: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Tomasz Rowicki, Mirosława Pietniczka-Załęska
Only a small number of cases of myiasis have been previously reported in patients with a head and neck malignancy; most of these occurred in patients with primary or metastatic skin cancer. We report a case of massive Lucilia sericata myiasis in the neck of a 57-year-old man with primary squamous cell carcinoma of the larynx and hypopharynx that metastasized to the neck lymph nodes. The neck disease manifested as necrosis and skin involvement. Clinical examination revealed an extensive wound within the neck tumor at levels II and V on the right that was heavily infested with maggot larvae...
April 2015: Ear, Nose, & Throat Journal
Zoltán Takácsi-Nagy, Erika Hitre, Éva Remenár, Ferenc Oberna, Csaba Polgár, Tibor Major, Mária Gödény, János Fodor, Miklós Kásler
PURPOSE: Concurrent chemoradiotherapy (CRT) is the standard treatment for advanced head and neck squamous cell carcinoma. In this phase II randomized study, the efficacy and toxicity of docetaxel, cisplatin and 5-fluorouracil induction chemotherapy (ICT) followed by concurrent CRT was compared with those after standard CRT alone in patients with locally advanced, unresectable head and neck cancer. PATIENTS AND METHODS: Between January 2007 and June 2009, 66 patients with advanced (stage III or IV) unresectable squamous cell carcinoma of the head and neck (oral cavity, oropharynx, hypopharynx, and larynx) were randomly assigned to two groups: one receiving two cycles of docetaxel, cisplatin, and 5-fluorouracil ICT followed by CRT with three cycles of cisplatin and one treated by CRT alone...
August 2015: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
Jeon Yeob Jang, Min Ji Kim, Gwanghui Ryu, Nayeon Choi, Young-Hyeh Ko, Han-Sin Jeong
PURPOSE: Lymph node metastasis (LNM) is a strong prognostic factor in many solid cancers, including head and neck squamous cell carcinomas (HNSCC), and LNM can be dependent upon primary tumor biology, as well as tumor dimension. Here, we investigate the relative risk of LNM in accordance to tumor dimension and biology in HNSCC subsites. MATERIALS AND METHODS: Medical data of 295 HNSCC patients who had undergone the initial curative surgery (oral tongue 174, oropharynx 75, hypopharynx 46) were analyzed to identify the significant predictive factor for LNM...
January 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Satish Nair, Sharad Mohan, Ajith Nilakantan, Atul Gupta, Akshat Malik, Abhishek Gupta
The efficacy of the whole body (WB) (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography (PET-CT) as a part of conventional initial staging in all cases of head and neck squamous cell carcinoma (HNSCC) is still controversial with various studies in literature giving contradictory reports. We conducted this study at a government tertiary care oncology center in India to identify the impact of WB (18)F-FDG PET-CT scan on HNSCC staging and treatment. A prospective clinical study of patients of HNSCC who were evaluated and treated at our center was performed...
January 2015: World Journal of Nuclear Medicine
Dirk Van Gestel, Danielle Van den Weyngaert, Geert De Kerf, Bie De Ost, Olivier Vanderveken, Carl Van Laer, Pol Specenier, Yasmyne Geussens, Kristien Wouters, Els Meulemans, Kin Jip Cheung, Vincent Grégoire, Jan B Vermorken
BACKGROUND: We report on a retrospective analysis of 147 patients with early and locoregionally advanced squamous cell head and neck cancer (SCCHN) treated with helical tomotherapy (HT). PATIENTS AND METHODS: Included were patients with SCCHN of the oral cavity (OC), oropharynx (OP), hypopharynx (HP), or larynx (L) consecutively treated in one radiotherapy center in 2008 and 2009. The prescribed HT dose was 60-66 Gy in the postoperative setting (group A) and 66-70 Gy when given as primary treatment (group B)...
March 2015: Oncologist
Ryusuke Imai, Yukinori Takenaka, Toshimichi Yasui, Susumu Nakahara, Yoshifumi Yamamoto, Atsushi Hanamoto, Norihiko Takemoto, Takahito Fukusumi, Hironori Cho, Masashi Yamamoto, Hidenori Inohara
CONCLUSIONS: Serum squamous cell carcinoma antigen (SCC-Ag) level was an independent prognostic factor for survival in patients with head and neck squamous cell carcinoma (HNSCC), and the prognostic value depended on the carcinoma site. OBJECTIVES: To assess the value of SCC-Ag as a prognostic indicator in patients with HNSCC and to determine the effect of primary tumor site on prognosis. METHODS: We reviewed 493 patients with HNSCC between 2004 and 2012...
March 2015: Acta Oto-laryngologica
Shu-Hang Ng, Chien-Yu Lin, Sheng-Chieh Chan, Yu-Chun Lin, Tzu-Chen Yen, Chun-Ta Liao, Joseph Tung-Chieh Chang, Sheung-Fat Ko, Hung-Ming Wang, Chee-Jen Chang, Jiun-Jie Wang
The clinical usefulness of pretreatment imaging techniques for predicting neck control in patients with oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC) treated with chemoradiation remains unclear. In this prospective study, we investigated the role of pretreatment dynamic contrast-enhanced perfusion MR imaging (DCE-PWI), diffusion-weighted MR imaging (DWI), and [18F]fluorodeoxyglucose-positron emission tomography (18F-FDG PET)/CT derived imaging markers for the prediction of neck control in OHSCC patients treated with chemoradiation...
2014: PloS One
David Landry, Christine M Glastonbury
Squamous cell carcinoma (SCCa) is the most common head and neck malignancy. The radiologist has several roles in the long-term management of patients with SCCa, the first of which is determining the extent of local disease spread and the presence of nodal metastases. The most widely used tumor staging system is the American Joint Committee on Cancer tumor node metastasis system, which creates the initial staging of SCCa patients. In this review the relevant reportable findings of pharyngeal SCCa are explored, and each subsite of the pharynx and larynx is addressed, from the nasopharynx to the hypopharynx...
January 2015: Radiologic Clinics of North America
Xiong-Xin Zhang, Kui Zhao, Shui-Hong Zhou, Qin-Ying Wang, Jian-Hua Liu, Zhong-Jie Lu
We herein present a case of a left cervical cystic mass, for which the initial pathological diagnosis was branchial cleft cyst carcinoma (following complete mass excision). Thorough postoperative examinations, including with FDG positron emission tomography/computed tomography (PET/CT), revealed a primary tumor in the retromolar region of the left mandible. A 52-year-old female presented with a 2-month history of a painless, progressively enlarged left-sided neck mass. Fine-needle aspiration biopsy suggested a branchial cleft cyst...
2014: International Journal of Clinical and Experimental Pathology
Arif N Ali, Jeffrey M Switchenko, Sungjin Kim, Jeanne Kowalski, Mark W El-Deiry, Jonathan J Beitler
BACKGROUND: The current study was conducted to develop a multifactorial statistical model to predict the specific head and neck (H&N) tumor site origin in cases of squamous cell carcinoma confined to the cervical lymph nodes ("unknown primaries"). METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was analyzed for patients with an H&N tumor site who were diagnosed between 2004 and 2011. The SEER patients were identified according to their H&N primary tumor site and clinically positive cervical lymph node levels at the time of presentation...
November 15, 2014: Cancer
Rocío González-Márquez, José Luis Llorente, Juan P Rodrigo, Juana M García-Pedrero, César Álvarez-Marcos, Carlos Suárez, Mario A Hermsen
Squamous cell carcinoma (SCC) of the head and neck display high frequencies of DNA copy number gains at chromosomal region 3q26-27. Recently SOX2 has been postulated as a driver oncogene for these amplifications; however, its role as a prognostic marker is still a matter of debate. The aim of this study was to evaluate the involvement of SOX2 protein expression in three different sublocalizations of head and neck SCC and its possible role as prognostic marker. SOX2 expression was analyzed by immunohistochemistry in 102 pharyngeal, 67 laryngeal, and 51 sinonasal SCCs, and the relation to clinicopathological and follow-up data was studied by χ(2) and Kaplan-Meier analysis...
April 2014: Human Pathology
Alvaro Sanabria, Carl E Silver, Kerry D Olsen, Jesus E Medina, Marc Hamoir, Vinidh Paleri, Vanni Mondin, Alessandra Rinaldo, Juan P Rodrigo, Carlos Suárez, Carsten C Boedeker, Michael L Hinni, Luiz P Kowalski, Afshin Teymoortash, Jochen A Werner, Robert P Takes, Alfio Ferlito
Among patients with head and neck squamous cell carcinoma with a negative neck who are initially treated with (chemo)radiotherapy, a number of cases will recur locally without obvious neck recurrence. There is little information available as to the most efficacious management of the neck in these cases. We have reviewed the literature to see what conclusions can be drawn from previous reports. We conducted a bibliography search on MEDLINE and EMBASE databases. Studies published in the English language and those on squamous cell carcinoma of the oral cavity, nasopharynx, oropharynx, larynx and hypopharynx were included...
December 2014: European Archives of Oto-rhino-laryngology
Lluís Nisa, Kaouthar Khanfir, Roland Giger
AIMS AND BACKGROUND: Tumor progression due to seeding of tumor cells after definitive treatment for squamous cell carcinomas of the head and neck is an uncommon condition that can considerably worsen the outcome of patients with head and neck cancer. METHODS AND STUDY DESIGN: We report two cases of recurrence due to neoplastic seeding from oropharyngeal and oral cancer, respectively. We performed a literature review with MEDLINE as the main search engine. RESULTS: Seeding was found to occur most often in tracheotomy scars and gastrostomy sites...
July 2013: Tumori
O Gallo, R Santoro, F R Fiorini, G Meccariello, R M Laganà, F Paiar, V Maio
BACKGROUND AND OBJECTIVES: Sparing internal jugular vein (IJV) in neck dissection for head and neck cancer is controversial. We aimed at evaluating the prognostic impact of IJV preservation. METHODS: We examined 206 files of head and neck cancer patients who underwent radical or modified radical neck dissection at the Otolaryngology University of Florence. The site of primary tumor was larynx and hypopharynx in 44.66%, oropharynx in 25.24%, oral cavity in 23.3%, unknown in 4...
December 2013: Journal of Surgical Oncology
Young-Hoon Joo, Kwang-Jae Cho, Jun-Ook Park, In-Chul Nam, Chung-Soo Kim, Hyun-Jin Cho, Min-Sik Kim
CONCLUSION: Factors that affected prognosis were T stage and extracapsular spread in patients that underwent primary surgery with postoperative radiotherapy for pN2 head and neck carcinoma. OBJECTIVES: The purpose of this study was to examine treatment outcomes and define prognostic factors for pN2 head and neck carcinoma. METHODS: A total of 209 patients underwent surgery with postoperative radiotherapy between 1994 and 2011. Primary tumor sites were the oropharynx (n = 70), hypopharynx (n = 48), larynx (n = 47), and oral cavity (n = 44)...
October 2013: Acta Oto-laryngologica
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