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J Tran, D S Dorstyn, A L J Burke
STUDY DESIGN: Meta-analysis. OBJECTIVES: Although the association between modifiable psychosocial factors and spinal cord injury (SCI) pain has been identified, the full range of psychological and social difficulties for those who experience acute and/or persistent pain remains unclear. This meta-analysis consolidates the available evidence, using the International Classification of Functioning, Disability and Health (ICF) as a reference framework. METHODS: Nineteen studies that examined persistent neuropathic, nociceptive or mixed pain subtypes in adults with a SCI (newly acquired and chronic; Nparticipants=2934) were identified from electronic database searches...
September 2016: Spinal Cord
Maria Jastrzebska, Dorota Tarnawska, Roman Wrzalik, Artur Chrobak, Michal Grelowski, Edward Wylegala, Dorota Zygadlo, Alicja Ratuszna
Collagen fibrils type I display a typical banding pattern, so-called D-periodicity, of about 67 nm, when visualized by atomic force or electron microscopy imaging. Herein we report on a significant shortening of the D-period for human corneal collagen fibrils type I (21±4 nm) upon air-drying, whereas no changes in the D-period were observed for human scleral collagen fibrils type I (64±4 nm) measured under the same experimental conditions as the cornea. It was also found that for the corneal stroma fixed with glutaraldehyde and air-dried, the collagen fibrils show the commonly accepted D-period of 61±8 nm...
February 12, 2016: Journal of Biomolecular Structure & Dynamics
Suresh Basnet, Andrzej Kozikowski, Amgad N Makaryus, Renee Pekmezaris, Roman Zeltser, Meredith Akerman, Martin Lesser, Gisele Wolf-Klein
BACKGROUND: Although animal studies have documented metformin's cardioprotective effects, the impact in humans remains elusive. The study objective was to explore the association between metformin and myocardial infarct size in patients with diabetes presenting with ST-segment elevation myocardial infarction. METHODS AND RESULTS: Data extraction used the National Cardiovascular Data CathPCI Registry in all patients with diabetes aged >18 years presenting with ST-segment elevation myocardial infarction at 2 academic medical centers from January 2010 to December 2013...
October 2015: Journal of the American Heart Association
Ling Gong, Wen Li, Dajun Zhang, Detlef H Rost
BACKGROUND AND OBJECTIVES: Few studies related to the impact of different emotion regulation strategies on anxiety have used externally and ecologically valid emotion-eliciting stimuli or Eastern populations. The present study compares the effects of reappraisal, suppression, and acceptance on anxiety induced by a simulated job interview in a Chinese sample. METHODS: Eighty-two subjects were randomly assigned to one of four instructions: reappraisal, suppression, acceptance, or no-regulation strategies during a simulated job interview...
June 19, 2015: Anxiety, Stress, and Coping
Michael T Englander, Joshua L Avins, Rachel C Fleisher, Bo Liu, Philip R Effraim, Jiangning Wang, Klaus Schulten, Thomas S Leyh, Ruben L Gonzalez, Virginia W Cornish
The cellular translational machinery (TM) synthesizes proteins using exclusively L- or achiral aminoacyl-tRNAs (aa-tRNAs), despite the presence of D-amino acids in nature and their ability to be aminoacylated onto tRNAs by aa-tRNA synthetases. The ubiquity of L-amino acids in proteins has led to the hypothesis that D-amino acids are not substrates for the TM. Supporting this view, protein engineering efforts to incorporate D-amino acids into proteins using the TM have thus far been unsuccessful. Nonetheless, a mechanistic understanding of why D-aa-tRNAs are poor substrates for the TM is lacking...
May 12, 2015: Proceedings of the National Academy of Sciences of the United States of America
David J Kearney, Carolyn McManus, Carol A Malte, Michelle E Martinez, Benjamin Felleman, Tracy L Simpson
BACKGROUND: Loving-kindness meditation (LKM) is a practice intended to enhance feelings of kindness and compassion for self and others. OBJECTIVES: To assess whether participation in a 12-week course of LKM for veterans with posttraumatic stress disorder (PTSD) is associated with improved positive emotions, decentering, and personal resources. RESEARCH DESIGN: In an open-pilot trial, veterans were assessed at baseline, after the course, and 3 months later...
December 2014: Medical Care
Jacob M Larsen, Sam Riahi, Jens B Johansen, Jens C Nielsen, Helen H Petersen, Jens Haarbo, Susanne S Pedersen
BACKGROUND: The St Jude Medical Riata lead advisory was issued owing to insulation failures. The impact of this advisory on patients' well-being is unknown. OBJECTIVES: The objectives of this study were to describe the acute impact of the Riata advisory on patients' well-being and psychological functioning and to examine changes over time. METHODS: Patients with active Riata leads completed standardized and validated patient-reported outcomes (PROs) in connection with a nationwide fluoroscopic screening with 12-month follow-up...
December 2014: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Tracy Epton, Peter R Harris, Rachel Kane, Guido M van Koningsbruggen, Paschal Sheeran
OBJECTIVES: Self-affirmation (induced by reflecting upon important values, attributes, or social relations) appears to reduce defensive resistance to health-risk information and increase subsequent readiness for health behavior change. However, these effects of self-affirmation have yet to be subjected to formal, quantitative integration. Consequently, the current article reports a meta-analysis of the impact of self-affirmation on outcomes at 3 key points in the process of health-behavior change: (a) message acceptance, (b) intentions to change, and (c) subsequent behavior...
March 2015: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
Amarendra Nath Maity, Yung-Han Chen, Shyue-Chu Ke
Lysine 5,6-aminomutase (5,6-LAM) and ornithine 4,5-aminomutase (4,5-OAM) are two of the rare enzymes that use assistance of two vitamins as cofactors. These enzymes employ radical generating capability of coenzyme B12 (5'-deoxyadenosylcobalamin, dAdoCbl) and ability of pyridoxal-5'-phosphate (PLP, vitamin B6) to stabilize high-energy intermediates for performing challenging 1,2-amino rearrangements between adjacent carbons. A large-scale domain movement is required for interconversion between the catalytically inactive open form and the catalytically active closed form...
2014: International Journal of Molecular Sciences
Lance M McCracken, Ayana Sato, Gordon J Taylor
UNLABELLED: Acceptance and commitment therapy (ACT) is a developing approach for chronic pain. The current study was designed to pilot test a brief, widely inclusive, local access format of ACT in a UK primary care setting. Seventy-three participants (68.5% women) were randomized to either ACT or treatment as usual (TAU). Many of the participants were aged 65 years or older (27.6%), were diagnosed with fibromyalgia (30.2%) and depression (40.3%), and had longstanding pain (median = 10 years)...
November 2013: Journal of Pain: Official Journal of the American Pain Society
Johanna E Vriezekolk, Agnes M M Eijsbouts, Wim G J M van Lankveld, Hanneke Beenackers, Rinie Geenen, Cornelia H M van den Ende
OBJECTIVE: To examine the potential effectiveness of a multimodal rehabilitation program including an acceptance-oriented cognitive-behavioral therapy for highly distressed patients with rheumatic diseases. METHODS: An observational study employing a one-group pre-post test design (N=25). The primary outcome was psychological distress. Secondary outcomes were quality of life, illness acceptance, and coping flexibility. Group pre-to-post and pre-to-12 months follow-up treatment changes were evaluated by paired-samples t-tests and Cohen's effect sizes (d)...
June 2013: Patient Education and Counseling
De-Lin Wu, Hai-Tang Zhang, Li-Min Liu, Guo-Yuan Lu, Ting-Chao He, Xiao-Qiang Zhang, Chang-Shun Wang
The photophysical and electrochemical properties of four novel donor-accepter (D-A) conjugated oligomers a-d based on 3,4-ethylenedioxythiophene (EDOT) and electrondeficient heterocycle rings were investigated. The UV-vis absorption spectroscopy, fluorescence emission spectroscopy and cyclic voltammertry studies suggest that the oligomers are expected to provide enhanced charge-transporting properties for the development of efficient electroluminescent materials. Furthermore, the third-order nonlinear optical (NLO) measurements made by Z-scan technique indicate that they have good third-order NLO response and are desired materias for fabricating nonlinear photonic devices...
December 2011: Journal of Nanoscience and Nanotechnology
David J Kearney, Kelly McDermott, Carol Malte, Michelle Martinez, Tracy L Simpson
OBJECTIVES: To assess outcomes of veterans who participated in mindfulness-based stress reduction (MBSR). DESIGN: Posttraumatic stress disorder (PTSD) symptoms, depression, functional status, behavioral activation, experiential avoidance, and mindfulness were assessed at baseline, and 2 and 6 months after enrollment. RESULTS: At 6 months, there were significant improvements in PTSD symptoms (standardized effect size, d = -0.64, p< 0.001); depression (d = -0...
January 2012: Journal of Clinical Psychology
József Csontos, Mihály Kállay
The currently accepted D(0)((35)Cl(2)) is 239.221 ± 0.001 kJ/mol, whereas popular theoretical model chemistries provide values in the range of 233-247 kJ/mol, and even the so-called high-accuracy protocols can yield values as low as 237.9 kJ/mol and as high as 240.1 kJ/mol for D(0)((35)Cl(2)). The aim of this study was to uncover the sources of error inherent in the theoretical approaches. Therefore, a coupled-cluster-based composite model chemistry was utilized that included contributions of up to pentuple excitations, as well as corrections beyond the nonrelativistic and Born-Oppenheimer approximations...
July 7, 2011: Journal of Physical Chemistry. A
Harry Boer, Hannu Maaheimo, Anu Koivula, Merja Penttilä, Peter Richard
There are at least three different pathways for the catabolism of D-galacturonate in microorganisms. In the oxidative pathway, which was described in some prokaryotic species, D-galacturonate is first oxidised to meso-galactarate (mucate) by a nicotinamide adenine dinucleotide (NAD)-dependent dehydrogenase (EC In the following steps of the pathway mucate is converted to 2-keto-glutarate. The enzyme activities of this catabolic pathway have been described while the corresponding gene sequences are still unidentified...
April 2010: Applied Microbiology and Biotechnology
Emilie Chambellon, Liesbeth Rijnen, Frédérique Lorquet, Christophe Gitton, Johan E T van Hylckama Vlieg, Jeroen A Wouters, Mireille Yvon
Hydroxyacid dehydrogenases of lactic acid bacteria, which catalyze the stereospecific reduction of branched-chain 2-keto acids to 2-hydroxyacids, are of interest in a variety of fields, including cheese flavor formation via amino acid catabolism. In this study, we used both targeted and random mutagenesis to identify the genes responsible for the reduction of 2-keto acids derived from amino acids in Lactococcus lactis. The gene panE, whose inactivation suppressed hydroxyisocaproate dehydrogenase activity, was cloned and overexpressed in Escherichia coli, and the recombinant His-tagged fusion protein was purified and characterized...
February 2009: Journal of Bacteriology
Nora Shields, Nicholas F Taylor, Karen J Dodd
The literature was systematically reviewed to determine if children with spina bifida have lower self-concept compared with their peers with typical development. Relevant trials were identified by searching electronic databases, supplemented by citation tracking. Of 803 papers initially identified, 15 met the inclusion criteria. Meta-analysis revealed children with spina bifida scored significantly lower than children with typical development for the domains of global self-worth (d=-0.39, 95% confidence interval [CI] -0...
October 2008: Developmental Medicine and Child Neurology
Linda A Jackson, Yong Zhao, Wei Qiu, Anthony Kolenic, Hiram E Fitzgerald, Rena Harold, Alexander Von Eye
In this research, we examined cultural differences in morality in the real and virtual worlds and the relationship between the two. Approximately 600 Chinese and 600 U.S. youth, average age 12 years old, completed surveys assessing their moral attitudes and behavior in the real world and the acceptability of a diverse set of morally questionable online behaviors. Findings indicated that (a) Chinese youth considered good moral character to be more important than did U.S. youth, whereas U.S. youth considered exceptions to moral behavior that advanced individual goals to be more acceptable than did Chinese youth; (b) Chinese females had the highest level of moral behavior, followed by U...
June 2008: Cyberpsychology & Behavior
Yuki Goto, Hiroshi Murakami, Hiroaki Suga
Here we report experimental evidence that the translation initiation apparatus accepts D-amino acids ((D)aa), as opposed to only L-methionine, as initiators. Nineteen (D)aa, as the stereoisomers to their natural L-amino acids, were charged onto initiator tRNA(fMet)(CAU) using flexizyme technology and tested for initiation in a reconstituted Escherichia coli translation system lacking methionine, i.e., the initiator was reprogrammed from methionine to (D)aa. Remarkably, all (D)aa could initiate translation while the efficiency of initiation depends upon the type of side chain...
July 2008: RNA
Ryan Sullivan, Huimin Zhao
An NAD(+)-dependent L-arabinitol 4-dehydrogenase (LAD, EC from Neurospora crassa was cloned and expressed in Escherichia coli and purified to homogeneity. The enzyme was a homotetramer and contained two Zn(2+) ions per subunit, displaying similar characteristics to medium-chain sorbitol dehydrogenases (SDHs). High enzymatic activity was observed for substrates L-arabinitol, adonitol, and xylitol and no activity for D-mannitol, D-arabinitol, or D-sorbitol. The enzyme showed strong preference for NAD(+) but also displayed a very low yet detectable activity with NADP(+)...
December 2007: Applied Microbiology and Biotechnology
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