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https://www.readbyqxmd.com/read/29206487/role-of-catechins-on-et-1-induced-stimulation-of-pld-and-nadph-oxidase-activities-in-pulmonary-smooth-muscle-cells-determination-of-the-probable-mechanism-by-molecular-docking-studies
#1
Sajal Chakraborti, Jaganmay Sarkar, Rajabrata Bhuyan, Tapati Chakraborti
Treatment of human pulmonary artery smooth muscle cells with ET-1 stimulated PLD and NADPH oxidase activities, which were inhibited upon pretreatment with bosentan (ET-1 receptor antagonist), FIPI (PLD inhibitor), apocynin (NADPH oxidase inhibitor) and EGCG & ECG (catechins having galloyl group), but not EGC & EC (catechins devoid of galloyl group). Herein, we determined the probable mechanism by which the galloyl group containing catechins inhibit ET-1 induced stimulation of PLD activity by molecular docking analyses based on our biochemical studies...
December 5, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29206236/structural-basis-for-the-substrate-selectivity-of-helicobacter-pylori-nuct-nuclease-activity
#2
Louisa Celma, Christopher Corbinais, Julien Vercruyssen, Xavier Veaute, Inès Li de la Sierra-Gallay, Raphaël Guérois, Didier Busso, Aurélie Mathieu, Stéphanie Marsin, Sophie Quevillon-Cheruel, J Pablo Radicella
The Phospholipase D (PLD) superfamily of proteins includes a group of enzymes with nuclease activity on various nucleic acid substrates. Here, with the aim of better understanding the substrate specificity determinants in this subfamily, we have characterised the enzymatic activity and the crystal structure of NucT, a nuclease implicated in Helicobacter pylori purine salvage and natural transformation and compared them to those of its bacterial and mammalian homologues. NucT exhibits an endonuclease activity with a strong preference for single stranded nucleic acids substrates...
2017: PloS One
https://www.readbyqxmd.com/read/29205059/5tr1-aptamer-pegylated-liposomal-doxorubicin-enhances-cellular-uptake-and-suppresses-tumour-growth-by-targeting-muc1-on-the-surface-of-cancer-cells
#3
Seyedeh Alia Moosavian, Khalil Abnous, Javad Akhtari, Leila Arabi, Ali Gholamzade Dewin, Mahmoudreza Jafari
Employing targeting ligands with high affinity to tumour receptors is an important strategy to increase treatment efficacy. The use of aptamers as targeting agent is increasingly prevalent in drug delivery systems. Mucin1 (MUC1) is a glycoprotein that is over-expressed on the surface of several cancer cells and plays an important role in metastasis and invasion. 5TR1-aptamer is a DNA aptamer, which targets MUC1 receptors. The present study investigated the anti-tumour activity and therapeutic effectiveness of 5TR1-aptamer-PEGylated liposomal doxorubicin (PLD) delivery system in C26 tumour-bearing mice...
December 5, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29175241/clinical-management-of-polycystic-liver-disease
#4
REVIEW
René M M van Aerts, Liyanne F M van de Laarschot, Jesus M Banales, Joost P H Drenth
In this Grand Round we present a typical case of a woman with polycystic liver disease (PLD). This case prompts questions which both patients and clinicians may face in clinical practice. This article aims to provide guidance to clinicians in the care of PLD patients in relation to recent key development in the field. We discuss the latest novelties in pathophysiology, natural course of disease, complications and treatment options. Finally, we discuss other potential new and effective therapies.
November 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29174203/phase-i-ii-trial-of-combined-pegylated-liposomal-doxorubicin-and-cyclophosphamide-in-metastatic-breast-cancer
#5
Amy E Chang, Qian V Wu, Isaac C Jenkins, Jennifer M Specht, Vijayakrishna K Gadi, Julie R Gralow, Lupe G Salazar, Brenda F Kurland, Hannah M Linden
INTRODUCTION: Doxorubicin in combination with cyclophosphamide is active in breast cancer; however, its use in metastatic cancer is limited owing to cardiotoxicity. Pegylated liposomal doxorubicin (PLD) was formulated to decrease the toxicity of conventional doxorubicin. We evaluated the safety and efficacy of PLD with metronomic oral cyclophosphamide. PATIENTS AND METHODS: We conducted a single-arm open-label phase I/II study of PLD and oral cyclophosphamide in patients with metastatic breast cancer...
October 9, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29171262/high-yield-and-sustainable-production-of-phosphatidylserine-in-purely-aqueous-solutions-via-adsorption-of-phosphatidylcholine-on-triton-x-100-modified-silica
#6
Xiaoli Zhang, Binglin Li, Jiao Wang, Huanyu Li, Bin-Xia Zhao
Triton X-100 was covalently bound to the surface of silica and acted as an anchor molecule to facilitate the adsorption of phosphatidylcholine (PC) in purely aqueous solutions. The silica-adsorbed PC obtained was successfully used for phospholipase D (PLD)-mediated transphosphatidylation for the production of phosphatidylserine (PS). Organic solvents were completely avoided in the whole production process. The PC loading and PS yield reached 98.9% and 99.0%, respectively. Meanwhile, two adsorption models were studied and relevant parameters were caculated to help understanding adsorption and reaction processes deeply...
November 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29167800/cross-species-complementation-of-bacterial-and-eukaryotic-type-cardiolipin-synthases
#7
Petra Gottier, Mauro Serricchio, Rita Vitale, Angela Corcelli, Peter Bütikofer
The glycerophospholipid cardiolipin is a unique constituent of bacterial and mitochondrial membranes. It is involved in forming and stabilizing high molecular mass membrane protein complexes and in maintaining membrane architecture. Absence of cardiolipin leads to reduced efficiency of the electron transport chain, decreased membrane potential, and, ultimately, impaired respiratory metabolism. For the protozoan parasite Trypanosoma brucei cardiolipin synthesis is essential for survival, indicating that the enzymes involved in cardiolipin production represent potential drug targets...
November 3, 2017: Microbial Cell
https://www.readbyqxmd.com/read/29164606/safety-and-efficacy-of-pomalidomide-dexamethasone-and-pegylated-liposomal-doxorubicin-for-patients-with-relapsed-or-refractory-multiple-myeloma
#8
Alexa Cohen, Tanya M Spektor, Laura Stampleman, Alberto Bessudo, Peter J Rosen, Leonard M Klein, Thomas Woliver, Marshall Flam, Shahrooz Eshaghian, Youram Nassir, Tina Maluso, Regina A Swift, Robert Vescio, James R Berenson
Immunomodulatory drugs including thalidomide, lenalidomide (LEN) and pomalidomide (POM), are effective for treating multiple myeloma (MM). POM has shown enhanced efficacy with dexamethasone (DEX). Pegylated liposomal doxorubicin (PLD) with bortezomib is US Food and Drug Administration-approved for treating MM. PLD with LEN or thalidomide has shown efficacy for MM patients. LEN with DEX, PLD and bortezomib achieves high response rates. We evaluated the combination of POM with DEX 40 mg and PLD 5 mg/m(2) with the latter two drugs administered on days 1, 4, 8 and 11 on a 28-day cycle for the treatment of relapsed/refractory MM patients...
November 21, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29158632/impact-of-postharvest-exogenous-%C3%AE-aminobutyric-acid-treatment-on-cucumber-fruit-in-response-to-chilling-tolerance
#9
Parviz Malekzadeh, Fariba Khosravi-Nejad, Ali Asghar Hatamnia, Reza Sheikhakbari Mehr
Low-temperature storage is generally used to extend postharvest lifetime and to inhibit decay of cucumber fruit, but it also enhances the intensity of chilling injury. The capability of γ-aminobutyric acid to enhance antioxidant enzyme activities and reduce chilling injury was studied in cucumber (Cucumis sativus L.) fruit stored at 1 °C for 5 weeks. The purpose of this study was to define if the GABA-induced modification in antioxidant system and phospholipase activity is linked to the reduced chilling injury in cold-stored cucumber fruit...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29155913/probing-electrochemically-induced-resistive-switching-of-tio2-using-spm-techniques
#10
Wanheng Lu, Lai-Mun Wong, Shijie Wang, Kaiyang Zeng
Resistive switching on the nanoscale is an emerging research field and Scanning Probe Microscopy (SPM) is a powerful tool for studies in this area. Under the SPM tip, the electrical field is very high due to the small tip radius on the order of tens of nanometers, and this can enable a range of ionic/electrochemical phenomena during the resistive switching of the materials under the SPM tip. Although the ionic/electrochemical phenomena have long been considered vital for the resistive switching of materials, a few pieces of experimental evidence, as well as the decoupling of the effects of the electrochemical processes at different stages, are still needed...
November 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29154090/proliferative-and-metastatic-roles-for-phospholipase-d-in-mouse-models-of-cancer
#11
REVIEW
Eric Roth, Michael A Frohman
Phospholipase D (PLD) activity has been proposed to facilitate multiple steps in cancer progression including growth, metabolism, angiogenesis, and mobility. The canonical enzymes PLD1 and PLD2 enact their diverse effects through hydrolyzing the membrane lipid phosphatidylcholine to generate the second messenger and signaling lipid phosphatidic acid (PA). However, the widespread expression of PLD1 and PLD2 in normal tissues and the additional distinct enzymatic mechanisms through which PA can be generated have produced uncertainty regarding the optimal settings in which PLD inhibition might ameliorate cancer...
November 14, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/29145720/phospholipase-d-and-its-essential-role-in-cancer
#12
Ju Hwan Cho, Joong-Soo Han
The role of Phospholipase D (PLD) in cancer development and management has been a major area of interest for researchers. The purpose of this mini-review is to explore PLD and its distinct role during chemotherapy including anti-apoptotic function. PLD is an enzyme that belongs to the phospholipase super family and is found in a broad range of organisms such as viruses, yeast, bacteria, animals, and plants. The function and activity of PLD are widely dependent on and regulated by neurotransmitters, hormones, small monomeric GTPases, and lipids...
November 16, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29143042/synthesis-and-characterization-of-the-first-inhibitor-of-n-acylphosphatidylethanolamine-phospholipase-d-nape-pld
#13
Beatrice Castellani, Eleonora Diamanti, Daniela Pizzirani, Piero Tardia, Martina Maccesi, Natalia Realini, Paola Magotti, Gianpiero Garau, Thomas Bakkum, Silvia Rivara, Marco Mor, Daniele Piomelli
N-Acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is a membrane-associated zinc enzyme that catalyzes the hydrolysis of N-acylphosphatidylethanolamines (NAPEs) into fatty acid ethanolamides (FAEs). Here, we describe the identification of the first small-molecule NAPE-PLD inhibitor, the quinazoline sulfonamide derivative 2,4-dioxo-N-[4-(4-pyridyl)phenyl]-1H-quinazoline-6-sulfonamide, ARN19874.
November 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29141586/profiling-membrane-glycerolipids-during-%C3%AE-ray-induced-membrane-injury
#14
Guowei Zheng, Weiqi Li
BACKGROUND: γ-rays are high-energy radiation that cause a range of random injuries to plant cells. Most studies on this issue have focused on γ-ray-induced nucleotide damage and the production of reactive oxygen species in cells, so little is known about the glycerolipid metabolism during γ-rays induced membrane injury. Using an ESI-MS/MS-based lipidomic method, we analysed the lipidome changes in wild-type and phospholipase D (PLD)δ- and α1-deficient Arabidopsis after γ-ray treatment...
November 15, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29136407/phospholipase-d-inhibitors-reduce-human-prostate-cancer-cell-proliferation-and-colony-formation
#15
Amanda R Noble, Norman J Maitland, Daniel M Berney, Martin G Rumsby
BACKGROUND: Phospholipases D1 and D2 (PLD1/2) hydrolyse cell membrane glycerophospholipids to generate phosphatidic acid, a signalling lipid, which regulates cell growth and cancer progression through effects on mTOR and PKB/Akt. PLD expression and/or activity is raised in breast, colorectal, gastric, kidney and thyroid carcinomas but its role in prostate cancer (PCa), the major cancer of men in the western world, is unclear. METHODS: PLD1 protein expression in cultured PNT2C2, PNT1A, P4E6, LNCaP, PC3, PC3M, VCaP, 22RV1 cell lines and patient-derived PCa cells was analysed by western blotting...
November 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29134950/structural-magnetic-and-electronic-properties-of-pulsed-laser-deposition-grown-srfeo3-%C3%AE-thin-films-and-srfeo3-%C3%AE-la2-3ca1-3mno3-multilayers
#16
E Perret, K Sen, J Khmaladze, B P P Mallett, M Yazdi-Rizi, P Marsik, S Das, I Marozau, M A Uribe-Laverde, R de Andrés Prada, J Strempfer, M Döbeli, N Biškup, M Varela, Y-L Mathis, C Bernhard
We studied the structural, magnetic and electronic properties of [Formula: see text] (SFO) thin films and [Formula: see text]/[Formula: see text] [Formula: see text]MnO3 (LCMO) superlattices that have been grown with pulsed laser deposition (PLD) on [Formula: see text] [Formula: see text] [Formula: see text] [Formula: see text] [Formula: see text] (LSAT) substrates. X-ray reflectometry and scanning transmission electron microscopy (STEM) confirm the high structural quality of the films and flat and atomically sharp interfaces of the superlattices...
November 14, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29123674/characterization-of-temporal-coherence-of-hard-x-ray-free-electron-laser-pulses-with-single-shot-interferograms
#17
Taito Osaka, Takashi Hirano, Yuki Morioka, Yasuhisa Sano, Yuichi Inubushi, Tadashi Togashi, Ichiro Inoue, Kensuke Tono, Aymeric Robert, Kazuto Yamauchi, Jerome B Hastings, Makina Yabashi
Temporal coherence is one of the most fundamental characteristics of light, connecting to spectral information through the Fourier transform relationship between time and frequency. Interferometers with a variable path-length difference (PLD) between the two branches have widely been employed to characterize temporal coherence properties for broad spectral regimes. Hard X-ray interferometers reported previously, however, have strict limitations in their operational photon energies, due to the specific optical layouts utilized to satisfy the stringent requirement for extreme stability of the PLD at sub-ångström scales...
November 1, 2017: IUCrJ
https://www.readbyqxmd.com/read/29114390/phospholipase-d-inhibition-by-hexanal-is-associated-with-calcium-signal-transduction-events-in-raspberry
#18
Walid El Kayal, Gopinadhan Paliyath, J Alan Sullivan, Jayasankar Subramanian
Raspberry (Rubus spp.) is an economically important crop with a restricted growing season and very limited fruit shelf-life due to its extreme tenderness. In order to prolong its shelf life, an aqueous composition containing hexanal as the key active ingredient (HC) was applied as a preharvest spray during fruit development. The effects of HC were assessed using physiological, biochemical and anatomical parameters on the treated fruits and compared with the effects of mock inoculation which lacked hexanal. Sugars and acidity did not show a significant change in response to HC treatment, while the pulling force (the tension required to detach the berry from the receptacle) significantly improved in the HC-treated fruits, compared to control...
2017: Horticulture Research
https://www.readbyqxmd.com/read/29104923/clickable-substrate-mimics-enable-imaging-of-phospholipase-d-activity
#19
Timothy W Bumpus, Jeremy M Baskin
Chemical imaging techniques have played instrumental roles in dissecting the spatiotemporal regulation of signal transduction pathways. Phospholipase D (PLD) enzymes affect cell signaling by producing the pleiotropic lipid second messenger phosphatidic acid via hydrolysis of phosphatidylcholine. It remains a mystery how this one lipid signal can cause such diverse physiological and pathological signaling outcomes, due in large part to a lack of suitable tools for visualizing the spatial and temporal dynamics of its production within cells...
October 25, 2017: ACS Central Science
https://www.readbyqxmd.com/read/29099189/quantitative-assessment-of-drug-delivery-to-tissues-and-association-with-phospholipidosis-a-case-study-with-two-structurally-related-diamines-in-development
#20
Irena Loryan, Edmund Hoppe, Klaus Hansen, Felix Held, Achim Kless, Klaus Linz, Virginia Marossek, Bert Nolte, Paul Ratcliffe, Derek Saunders, Rolf Terlinden, Anita Wegert, André Welbers, Olaf Will, Margareta Hammarlund-Udenaes
Drug induced phospholipidosis (PLD) may be observed in the preclinical phase of drug development and pose strategic questions. As lysosomes have a central role in pathogenesis of PLD, assessment of lysosomal concentrations is important for understanding the pharmacokinetic basis of PLD manifestation and forecast of potential clinical appearance. Herein we present a systematic approach to provide insight into tissue-specific PLD by evaluation of unbound intracellular and lysosomal (reflecting acidic organelles) concentrations of two structurally related diprotic amines, GRT1 and GRT2...
November 3, 2017: Molecular Pharmaceutics
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