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https://www.readbyqxmd.com/read/29660846/phospholipase-d2-promotes-disease-progression-of-renal-cell-carcinoma-through-the-induction-of-angiogenin
#1
Shuya Kandori, Takahiro Kojima, Taeko Matsuoka, Takayuki Yoshino, Aiko Sugiyama, Eijiro Nakamura, Toru Shimazui, Yuji Funakoshi, Yasunori Kanaho, Hiroyuki Nishiyama
A hallmark of clear cell renal cell carcinoma (ccRCC) is the presence of intracellular lipid droplets (LD) and it is assumed that phosphatidic acid (PA) produced by phospholipase D (PLD) plays some roles in the LD formation. However, little is known about the significance of PLD in ccRCC. In this study, we examined the expression levels of PLD in ccRCC. The classical mammalian isoforms of PLD are PLD1 and PLD2, and the levels of both mRNAs were higher at the primary tumor sites than in normal kidney tissues...
April 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29656494/oxidized-ldl-phagocytosis-during-foam-cell-formation-in-atherosclerotic-plaques-relies-on-a-pld2-cd36-functional-interdependence
#2
Ramya Ganesan, Karen M Henkels, Lucile E Wrenshall, Yasunori Kanaho, Gilbert Di Paolo, Michael A Frohman, Julian Gomez-Cambronero
The uptake of cholesterol carried by low-density lipoprotein (LDL) is tightly controlled in the body. Macrophages are not well suited to counteract the cellular consequences of excess cholesterol leading to their transformation into "foam cells," an early step in vascular plaque formation. We have uncovered and characterized a novel mechanism involving phospholipase D (PLD) in foam cell formation. Utilizing bone marrow-derived macrophages from genetically PLD deficient mice, we demonstrate that PLD2 (but not PLD1)-null macrophages cannot fully phagocytose aggregated oxidized LDL (Agg-Ox-LDL), which was phenocopied with a PLD2-selective inhibitor...
April 14, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29652995/-association-of-polymorphisms-of-nape-pld-and-faah-genes-with-schizophrenia-in-chinese-han-population
#3
Peiru Si, Shulian Liu, Dongxiao Tong, Meijin Cheng, Liwen Wang, Xiaoli Cheng
OBJECTIVE: To assess the association of polymorphisms of N-acyl-phosphatidylethanolamine-phospholipase D (DAPE-PLD) and fatty acid amide hydrolase (FAAH) genes, as well as their interaction, with schizophrenia. METHODS: Polymorphisms of NAPE-PLD rs12540583 and FAAH rs324420, rs2295633, and rs6429600 were determined with PCR - restriction fragment length polymorphism assay and Sanger sequencing. The genotypes of 345 subjects of Han Chinese origin diagnosed with schizophrenia and a 403 controls were compared...
April 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29643422/chasing-genetic-structure-in-coralligenous-reef-invertebrates-patterns-criticalities-and-conservation-issues
#4
Federica Costantini, Filippo Ferrario, Marco Abbiati
Conservation of coastal habitats is a global issue, yet biogenic reefs in temperate regions have received very little attention. They have a broad geographic distribution and are a key habitat in marine ecosystems impacted by human activities. In the Mediterranean Sea coralligenous reefs are biodiversity hot spots and are classified as sensitive habitats deserving conservation. Genetic diversity and structure influence demographic, ecological and evolutionary processes in populations and play a crucial role in conservation strategies...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29623421/trabectedin-plus-pegylated-liposomal-doxorubicin-pld-for-patients-with-platinum-sensitive-recurrent-ovarian-cancer-a-prospective-observational-multicenter-study
#5
Ingo B Runnebaum, Dietmar Reichert, Uta Ringsdorf, Markus Kuther, Tobias Hesse, Jalid Sehouli, Pauline Wimberger
PURPOSE: The OVA-YOND study is the first prospective, non-interventional trial designed to evaluate trabectedin (1.1 mg/m2 ) plus PLD (30 mg/m2 ) in patients with platinum-sensitive recurrent ovarian cancer (ROC), given according to the marketing authorization in real-life clinical practice across Germany. METHODS: Eligible patients were adults with platinum-sensitive ROC, pretreated with ≥ 1 platinum-containing regimen/s. The primary endpoint was to assess safety/tolerability of the combination...
April 6, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29622768/role-of-phospholipase-d-in-the-lifespan-of-caenorhabditis-elegans
#6
Jeong-Hwan Park, Jeong-Woo Park, Ju-Hyeon Lee, Dong-Yun Kim, Jeong-Hoon Hahm, Young-Seuk Bae
We have previously shown that phospholipase D (PLD) downregulation accelerates cellular senescence, which is widely believed to play an important role in aging, by stimulating reactive oxygen species (ROS) accumulation in human cells. In this study, we examined the role of PLD in aging using the nematode Caenorhabditis elegans. The mRNA level of pld-1 was found to be inversely correlated with aging. RNAi-mediated knockdown of pld-1 expression in nematodes enhanced ROS and lipofuscin accumulation and decreased lifespan, motility, and resistance to stress compared to that in nematodes treated with control RNAi...
April 6, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29620513/reliability-of-three-dimentional-pseudo-continuous-arterial-spin-labeling-a-volumetric-cerebral-perfusion-imaging-with-different-post-labeling-time-and-functional-state-in-health-adults
#7
Meng-Qi Liu, Zhi-Ye Chen, Lin Ma
Objective To evaluate the reliability of three dimensional spiral fast spin echo pseudo-continuous arterial spin labeling (3D pc-ASL) in measuring cerebral blood flow (CBF) with different post-labeling delay time (PLD) in the resting state and the right finger taping state. Methods 3D pc-ASL and three dimensional T1-weighted fast spoiled gradient recalled echo (3D T1-FSPGR) sequence were applied to eight healthy subjects twice at the same time each day for one week interval. ASL data acquisition was performed with post-labeling delay time (PLD) 1...
March 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29611139/identification-of-a-novel-phospholipase-d-gene-and-effects-of-carbon-sources-on-its-expression-in-bacillus-cereus-zy12
#8
Yu Zhao, Yinfeng Xu, Fang Yu, Chunzhi Zhang
In the present study, a new strain, Bacillus cereus ZY12, producing phospholipase D (PLD) was identified. The expression of PLD in this strain was found to be induced by its substrate, phosphatidylcholine (PC), and completely silenced by other carbon sources, such as glucose, fructose, and maltose, which are generally used in microbial growth cultures, thus presenting a unique expression pattern different from other PLD-producing microorganisms. This study is the first to report on the ability of B. cereus to produce PLD, and successfully clone its PLD-coding gene and identify its function, extending the knowledge on PLD distribution and evolution in microorganisms...
April 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29604140/cytidinediphosphate-diacylglycerol-synthase-5-is-required-for-phospholipid-homeostasis-and-is-negatively-involved-in-hyperosmotic-stress-tolerance
#9
Yue Hong, Shu Yuan, Linxiao Sun, Xuemin Wang, Yueyun Hong
Cytidinediphosphate diacylglycerol synthase (CDS) uses phosphatidic acid (PA) and cytidinetriphosphate to produce cytidinediphosphate-diacylglycerol, an intermediate for phosphatidylglycerol (PG) and phosphatidylinositol (PI) synthesis. This study shows that rice CDS5, one of the rice genome's five CDSs, has multifaceted effects on plant growth and stress responses. Loss of CDS5 resulted in a decrease in PG and PI levels, defective thylakoid membranes, pale leaves in seedlings, and growth retardation. In addition, the loss of CDS5 led to an elevated PA level and enhanced hyperosmotic tolerance...
March 31, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29601003/mechanism-of-large-optical-nonlinearity-in-gold-nanoparticle-films
#10
I Mirza, D McCloskey, W J Blau, J G Lunney
The Z-scan technique, using femtosecond (fs) laser pulses at 1480 nm laser pulses, was used to measure the nonlinear optical properties of gold (Au) nanoparticle (NP) films made by both nanosecond (ns) and fs pulsed laser deposition (PLD) in vacuum. At irradiance levels of 1×1012   Wm-2 , the ns-PLD films displayed induced absorption with β=4×10-5   mW-1 , and a negative lensing effect with n2 =-4.7×10-11   m2  W-1 with somewhat smaller values for the fs-PLD films. These values of n2 imply an unphysically large change in the real part of the refractive index, demonstrating the need to take account of nonlinear changes of the Fresnel coefficients and multiple beam interference in Z-scan measurements on nanoscale films...
April 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29580622/phospholipases-play-multiple-cellular-roles-including-growth-stress-tolerance-sexual-development-and-virulence-in-fungi
#11
REVIEW
Ananya Barman, Dibakar Gohain, Utpal Bora, Ranjan Tamuli
Phospholipases are ubiquitous enzymes that hydrolyze phospholipids. Based on the cleavage site of the ester linkage in the substrate phospholipids, phospholipases are classified into four major types, phospholipase A (PLA), phospholipase B (PLB), phospholipase C (PLC), and phospholipase D (PLD), which are further classified into various subtypes. Phospholipases hydrolyze phospholipids into various signaling products including phosphatidic acid (PA), diacylglycerol (DAG), free fatty acids (FFAs), and lyso-phospholipids (LPLs)...
April 2018: Microbiological Research
https://www.readbyqxmd.com/read/29579867/multicentric-study-of-the-andalusian-experience-in-polycystic-liver-disease-as-indication-for-liver-transplantation
#12
S Dios-Barbeito, M Domínguez-Bastante, A Moreno-Navas, F J León-Díaz, Y Fundora-Suárez, F J Briceño-Delgado, M Pitarch-Martínez, M Á Gómez-Bravo
BACKGROUND: The purpose of this study was to determine the morbidity and survival in patients with polycystic liver disease (PLD) undergoing liver transplantation (LT) in 4 Spanish hospitals. METHODS: A multicentric retrospective study using a prospective database was designed including 19 LTs after PLD diagnosis performed from January 1, 1990, to December 31, 2016. Pediatric patients were excluded from the analysis. RESULTS: Of the included patients, 63...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29571767/phospholipase-d1-downregulation-by-%C3%AE-synuclein-implications-for-neurodegeneration-in-parkinson-s-disease
#13
Melisa A Conde, Natalia P Alza, Pablo Iglesias Gonzalez, Paola G Scodelaro Bilbao, Sofia Sánchez Campos, Romina M Uranga, Gabriela A Salvador
We have previously shown that phospholipase D (PLD) pathways have a role in neuronal degeneration; in particular, we found that PLD activation is associated with synaptic injury induced by oxidative stress. In the present study, we investigated the effect of α-synuclein (α-syn) overexpression on PLD signaling. Wild Type (WT) α-syn was found to trigger the inhibition of PLD1 expression as well as a decrease in ERK1/2 phosphorylation and expression levels. Moreover, ERK1/2 subcellular localization was shown to be modulated by WT α-syn in a PLD1-dependent manner...
March 20, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29560412/elevated-phospholipase-d-isoform-1-in-alzheimer-s-disease-patients-hippocampus-relevance-to-synaptic-dysfunction-and-memory-deficits
#14
Balaji Krishnan, Rakez Kayed, Giulio Taglialatela
Introduction: Phospholipase D (PLD), a lipolytic enzyme that breaks down membrane phospholipids, is also involved in signaling mechanisms downstream of seven transmembrane receptors. Abnormally elevated levels of PLD activity are well-established in Alzheimer's disease (AD), implicating the two isoforms of mammalian phosphatidylcholine cleaving PLD (PC-PLD1 and PC-PLD2). Therefore, we took a systematic approach of investigating isoform-specific expression in human synaptosomes and further investigated the possibility of therapeutic intervention using preclinical studies...
2018: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29558478/larval-dispersal-in-three-coral-reef-decapod-species-influence-of-larval-duration-on-the-metapopulation-structure
#15
Laura Sanvicente-Añorve, Jorge Zavala-Hidalgo, Eugenia Allende-Arandía, Margarita Hermoso-Salazar
Most coral-associated decapod species have non-migratory adult populations and depend on their planktonic larvae for dispersal. This study examined the metapopulation structure of three decapod species with different pelagic larval duration (PLD) from twelve coral reef complexes of the Gulf of Mexico. The dispersion of larvae was analyzed through the use of a realistic numerical simulation of the Gulf of Mexico with the Hybrid Coordinate Ocean Model. To study the transport and dispersion of particles in near-surface waters, a particle-tracking subroutine was run using as input the currents from the model...
2018: PloS One
https://www.readbyqxmd.com/read/29557075/simulation-of-stimuli-responsive-and-stoichiometrically-controlled-release-rate-of-doxorubicin-from-liposomes-in-tumor-interstitial-fluid
#16
Eiichi Yamamoto, Kenji Hyodo, Takuya Suzuki, Hiroshi Ishihara, Hiroshi Kikuchi, Masaru Kato
PURPOSE: To simulate the stimuli-responsive and stoichiometrically controlled doxorubicin (DOX) release from liposomes in in vivo tumor interstitial fluid (TIF), the effect of ammonia concentration and pH on the DOX release from liposomes in human plasma at 37°C was quantitatively evaluated in vitro and the release rate was calculated as a function of ammonia concentration and pH. METHODS: Human plasma samples spiked with DOX-loaded PEGylated liposomes (PLD) or Doxil® , containing ammonia (0...
March 19, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29551989/could-arterial-spin-labeling-distinguish-patients-in-minimally-conscious-state-from-patients-in-vegetative-state
#17
Bing Wu, Yi Yang, Shuai Zhou, Wei Wang, Zizhen Wang, Gang Hu, Jianghong He, Xinhuai Wu
Purpose: Diagnostic error is common among patients with vegetative state (VS) and minimally conscious state (MCS). The purpose of this article is to use three-dimensional pseudo-continuous arterial spin labeling (pcASL) to compare cerebral blood flow (CBF) patterns in patients in MCS with those in VS. Methods: Patients meeting MCS and VS criteria were identified. Two post-labeling delay (PLD) time pcASL on 3.0-Tesla magnetic resonance imaging scanner system were performed with patients in the resting awake state...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29550061/lesion-focused-radiofrequency-thermocoagulation-of-bottom-of-sulcus-focal-cortical-dysplasia-type-iib-conceptional-considerations-with-regard-to-the-epileptogenic-zone
#18
Jörg Wellmer
Small bottom-of-sulcus focal cortical dysplasias (BOS-FCD) type IIb are intrinsically epileptogenic lesions often responsible for pharmacoresistant epilepsy. They are increasingly well demarcated in vivo from surrounding cortex and white matter by 3 T magnetic resonance imaging (MRI). These facts and frequent seizure freedom after just narrow resections allow questioning the classical concept of epilepsy surgery in which the epileptogenic lesion is generally considered only one part of the epileptogenic zone and the resection volume categorically has to exceed lesion limits...
February 19, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29528813/non-toxigenic-corynebacterium-ulcerans-sequence-types-325-and-339-isolated-from-two-dogs-with-ulcerative-lesions-in-italy
#19
Virginia Carfora, Fabia Scarampella, Manuela Iurescia, Valentina Donati, Fiorentino Stravino, Serena Lorenzetti, Erika Menichini, Alessia Franco, Andrea Caprioli, Antonio Battisti
Corynebacterium ulcerans, an emerging pathogen related to C. diphtheriae and C. pseudotuberculosis, is able to cause disease in both human and animal hosts. C. ulcerans may harbor acquired virulence factors such as dermonecrotic exotoxin phospholipase D (PLD) and the prophage-encoded diphtheria toxin (DT). Infections typically occur in persons reporting close contact with animals. In pets, C. ulcerans has been isolated from both asymptomatic carriers and clinically affected dogs and cats. We describe the isolation and characterization of C...
March 1, 2018: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29527442/combined-pulsed-laser-deposition-and-non-contact-atomic-force-microscopy-system-for-studies-of-insulator-metal-oxide-thin-films
#20
Daiki Katsube, Hayato Yamashita, Satoshi Abo, Masayuki Abe
We have designed and developed a combined system of pulsed laser deposition (PLD) and non-contact atomic force microscopy (NC-AFM) for observations of insulator metal oxide surfaces. With this system, the long-period iterations of sputtering and annealing used in conventional methods for preparing a metal oxide film surface are not required. The performance of the combined system is demonstrated for the preparation and high-resolution NC-AFM imaging of atomically flat thin films of anatase TiO2 (001) and LaAlO3 (100)...
2018: Beilstein Journal of Nanotechnology
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