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https://www.readbyqxmd.com/read/28642580/a-snake-venom-group-iia-pla2-with-immunomodulatory-activity-induces-formation-of-lipid-droplets-containing-15-d-pgj2-in-macrophages
#1
Karina Cristina Giannotti, Elbio Leiguez, Ana Eduarda Zulim de Carvalho, Neide Galvão Nascimento, Márcio Hideki Matsubara, Consuelo Latorre Fortes-Dias, Vanessa Moreira, Catarina Teixeira
Crotoxin B (CB) is a catalytically active group IIA sPLA2 from Crotalus durissus terrificus snake venom. In contrast to most GIIA sPLA2s, CB exhibits anti-inflammatory effects, including the ability to inhibit leukocyte functions. Lipid droplets (LDs) are lipid-rich organelles associated with inflammation and recognized as a site for the synthesis of inflammatory lipid mediators. Here, the ability of CB to induce formation of LDs and the mechanisms involved in this effect were investigated in isolated macrophages...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634499/three-input-gate-logic-circuits-on-chemically-assembled-single-electron-transistors-with-organic-and-inorganic-hybrid-passivation-layers
#2
Yutaka Majima, Guillaume Hackenberger, Yasuo Azuma, Shinya Kano, Kosuke Matsuzaki, Tomofumi Susaki, Masanori Sakamoto, Toshiharu Teranishi
Single-electron transistors (SETs) are sub-10-nm scale electronic devices based on conductive Coulomb islands sandwiched between double-barrier tunneling barriers. Chemically assembled SETs with alkanethiol-protected Au nanoparticles show highly stable Coulomb diamonds and two-input logic operations. The combination of bottom-up and top-down processes used to form the passivation layer is vital for realizing multi-gate chemically assembled SET circuits, as this combination enables us to connect conventional complementary metal oxide semiconductor (CMOS) technologies via planar processes...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28631775/-innovations-in-the-treatment-of-ovarian-cancer-analysis-of-the-therapeutic-development-from-platinum-to-immunotherapy
#3
Gesuino Angius, Pierangela Sepe, Anselmo Papa, Silverio Tomao, Federica Tomao
Ovarian cancer is the seventh most common cancer in women. The therapeutic approach provides for an appropriate integration between surgery and chemotherapy. Surgery is an important step for diagnosis, staging and therapy, aiming at the complete cytoreduction of all macroscopic visible disease. At the moment, adjuvant and first-line chemotherapy has as a standard the carboplatin-paclitaxel combination. Further, the addition of bevacizumab in the advanced stage (IIIB-IV) is strongly recommended. Despite the initial effectiveness, however, 70-80% of patients develop relapsed disease within the first two years and require subsequent treatment lines that have palliative, rather than curative purposes and that seek to reach a chronic state for the disease...
June 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28626402/effect-of-the-combination-of-trabectedin-and-pegylated-liposomal-doxorubicin-in-a-brca2-mutation-carrier-with-recurrent-platinum-sensitive-ovarian-cancer
#4
María Jesús Rubio Pérez
INTRODUCTION: The current standard of care for ovarian cancer is optimal cytoreduction with adjuvant chemotherapy based on a platinum/taxane combination. Although the response rate to this therapy is high, most patients ultimately relapse. Response to second-line therapy and prognosis are linked to the platinum-free interval (PFI); when both improve, the PFI increases. As a result, there is an increasing interest in the PFI extension strategies including platinum-free combinations. CASE PRESENTATION: A 50-year-old postmenopausal woman presented with ovarian serous carcinoma with peritoneal carcinomatosis...
May 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28621749/surface-acoustic-wave-sensors-for-hydrogen-and-deuterium-detection
#5
Aurelian Marcu, Cristian Viespe
A delay-line-type surface acoustic wave (SAW) sensor based on a zinc oxide (ZnO) sensitive layer was developed. Two types of sensitive layers were obtained: ZnO nanowires and ZnO thin films, both deposited using laser methods (VLS-PLD and PLD, respectively) onto quartz substrates. The responses of sensors with two different nanowire lengths (300 and 600 nm) were compared with those of sensors with thin films of different thicknesses (ca. 100 and 200 nm) to different concentrations of hydrogen and deuterium...
June 16, 2017: Sensors
https://www.readbyqxmd.com/read/28610993/effects-of-a-co-micronized-composite-containing-palmitoylethanolamide-and-polydatin-in-an-experimental-model-of-benign-prostatic-hyperplasia
#6
Marika Cordaro, Daniela Impellizzeri, Rosalba Siracusa, Enrico Gugliandolo, Roberta Fusco, Antonino Inferrera, Emanuela Esposito, Rosanna Di Paola, Salvatore Cuzzocrea
Palmitoylethanolamide (PEA), a fatty acid amide-signaling molecule has well-known anti-inflammatory and neuroprotective effects. Nevertheless, PEA does not possess the ability to prevent free radicals formation. Polydatin (PLD), a biological precursor of resveratrol, has antioxidant activity. A combination of PEA and PLD could, conceivably, have beneficial effects on oxidative stress produced by inflammatory processes. In the present study we investigated the effects of a co-micronized composite containing PEA and PLD (m(PEA/PLD)) in a model of testosterone-induced benign hyperplasia (BPH)...
June 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28608817/recombinant-phospholipase-d-from-loxosceles-gaucho-binds-to-platelets-and-promotes-phosphatidylserine-exposure
#7
Daniel A Fukuda, Maria C Caporrino, Katia C Barbaro, Maisa S Della-Casa, Eliana L Faquim-Mauro, Geraldo S Magalhaes
Spider envenomation, from the genus Loxosceles, is frequently reported as a cause of necrotic lesions in humans around the world. Among the many components found in the venom of Loxosceles genus, phospholipases D (PLDs) are the most investigated, since they can cause a massive inflammatory response, dermonecrosis, hemolysis and platelet aggregation, among other effects. Even though the PLDs induce strong platelet aggregation, there are no studies showing how the PLDs interact with platelets to promote this effect...
June 13, 2017: Toxins
https://www.readbyqxmd.com/read/28596183/leptogenic-effects-of-n-acyl-phosphatidylethanolamine-nape-requires-activity-of-n-acylphosphatidylethanolamine-hydrolyzing-phospholipase-d-nape-pld
#8
Zhongyi Chen, Yongqin Zhang, Lilu Guo, Noura Dosoky, Lorenzo De Ferra, Scott Peters, Kevin D Niswender, Sean S Davies
Food intake induces synthesis of N-acylphosphatidylethanolamines (NAPEs) in the intestinal tract. While NAPEs exert leptin-like (leptogenic) effects including reduced food intake and weight gain, the mechanisms by which NAPEs induce these leptogenic effects remain unclear. One key question is whether intestinal NAPEs act directly on cognate receptors or first require conversion to N-acylethanolamides (NAEs) by NAPE-hydrolyzing phospholipase D (NAPE-PLD). Previous studies using Nape-pld-/- mice were equivocal because intraperitoneal injection of NAPEs led to non-specific, aversive effects...
June 8, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28586022/small-protein-a-and-phospholipase-d-immunization-serves-a-protective-role-in-a-mouse-pneumonia-model-of-acinetobacter%C3%A2-baumannii-infection
#9
Haitao Li, Hongyi Tan, Yongbin Hu, Pinhua Pan, Xiaoli Su, Chengpin Hu
Acinetobacter baumannii is an important pathogen that primarily causes hospital-acquired pneumonia. The present study sought to investigate whether small protein A (SmpA) and phospholipase D (PLD) are potential candidates for protective immunity against infection with A. baumannii. Mice immunized with the fusion proteins histidine (His)‑SmpA and His‑PLD exhibited a specific immunoglobulin G response. In a pneumonia model, active and passive immunization against SmpA and PLD protected mice from A. baumannii infection...
June 6, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28580780/monolithic-mid-infrared-integrated-photonics-using-silicon-on-epitaxial-barium-titanate-thin-films
#10
Tiening Jin, Leigang Li, Bruce Zhang Bzhang Gmail Com Zhang, Hao-Yu Greg Lin, Haiyan Wang, Pao Lin
Broadband mid-Infrared (mid-IR) photonic circuits that integrate silicon waveguides and epitaxial barium titanate (BTO) thin films are demonstrated using the complementary metal-oxide-semiconductor (CMOS) process. The epitaxial BTO thin films are grown on lanthanum aluminate (LAO) substrates by pulsed laser deposition (PLD) technique, where a broad infrared transmittance between λ = 2.5 µm to λ = 7 um is observed. The optical waveguiding direction is defined by the high refractive index amorphous Si (a-Si) ridge structure developed on the BTO layer...
June 5, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28579484/acylethanolamides-and-endocannabinoid-signaling-system-in-dorsal-striatum-of-rats-exposed-to-perinatal-asphyxia
#11
Mariana I Holubiec, Juan I Romero, Eduardo Blanco, Tamara Logica Tornatore, Juan Suarez, Fernando Rodríguez de Fonseca, Pablo Galeano, Francisco Capani
Endocannabinoids (eCBs) and acylethanolamides (AEs) have lately received more attention due to their neuroprotective functions in neurological disorders. Here we analyze the alterations induced by perinatal asphyxia (PA) in the main metabolic enzymes and receptors of the eCBs/AEs in the dorsal striatum of rats. To induce PA, we used a model developed by Bjelke et al. (1991). Immunohistochemical techniques were carried out to determine the expression of neuronal and glial markers (NeuN and GFAP), eCBs/AEs synthesis and degradation enzymes (DAGLα, NAPE-PLD and FAAH) and their receptors (CB1 and PPARα)...
June 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28574933/real-world-management-of-trabectedin-pegylated-liposomal-doxorubicin-in-platinum-sensitive-recurrent-ovarian-cancer-patients-a-national-survey
#12
Gabriella Ferrandina, Giulia Amadio, Ida Paris, Mariagrazia Distefano, Eleonora Palluzzi, Rosa de Vincenzo, Caterina Ricci, Giovanni Scambia
BACKGROUND: Trabectedin (T) plus pegylated liposomal doxorubicin (PLD) is approved for treatment of platinum-sensitive recurrent ovarian cancer (ROC). Despite the recommendations and guidelines, variations in managing T/PLD administration in routine clinical practice cannot be excluded. We aimed at setting up an Italian survey collecting data about management of T/PLD administration in ROC patients. METHODS: We carried out the development of a questionnaire-based survey on routine clinical practice in the management of ROC patients administered T/PLD...
June 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28574068/self-assembled-co-bazro3-nanocomposite-thin-films-with-ultra-fine-vertically-aligned-co-nanopillars
#13
Jijie Huang, Leigang Li, Ping Lu, Zhimin Qi, Xing Sun, Xinghang Zhang, Haiyan Wang
A simple one-step pulsed laser deposition (PLD) method has been applied to grow self-assembled metal-oxide nanocomposite thin films. The as-deposited Co-BaZrO3 films show high epitaxial quality with ultra-fine vertically aligned Co nanopillars (diameter <5 nm) embedded in a BZO matrix. The diameter of the nanopillars can be further tuned by varying the deposition frequency. The metal and oxide phases grow separately without inter-diffusion or mixing. Taking advantage of this unique structure, a high saturation magnetization of ∼1375 emu cm(-3) in the Co-BaZrO3 nanocomposites has been achieved and further confirmed by Lorentz microscopy imaging in TEM...
June 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28566679/combined-magnetron-sputtering-and-pulsed-laser-deposition-of-tio-2-and-bfco-thin-films
#14
D Benetti, R Nouar, R Nechache, H Pepin, A Sarkissian, F Rosei, J M MacLeod
We report the successful demonstration of a hybrid system that combines pulsed laser deposition (PLD) and magnetron sputtering (MS) to deposit high quality thin films. The PLD and MS simultaneously use the same target, leading to an enhanced deposition rate. The performance of this technique is demonstrated through the deposition of titanium dioxide and bismuth-based perovskite oxide Bi2FeCrO6 (BFCO) thin films on Si(100) and LaAlO3 (LAO) (100). These specific oxides were chosen due to their functionalities, such as multiferroic and photovoltaic properties (BFCO) and photocatalysis (TiO2)...
May 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28561200/-exposure-of-adolescents-to-leisure-time-noise-results-of-the-first-follow-up-of-the-ohrkan-cohort-study
#15
Doris Gerstner, Dorothee Twardella, Christina Reiter, Veronika Weilnhammer, Stefanie Kolb, Caroline Eva Wella Herr
Objective Analysis of changes in leisure noise exposure among adolescents during 2.5 years of follow-up. Methods The analysis is based on the Ohrkan cohort study. A total of 2 149 9(th) graders in the City of Regensburg (mostly aged 15-16 years) were recruited between 2009-2011. At 2.5-year follow-up, the participants were asked again about leisure noise exposure. Both at baseline (O-I) and in the follow-up (O-II), self-reported frequency of participation in noisy activities was combined with literature-based values of usual sound levels to calculate the total weekly noise exposure...
May 29, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28553832/preoperative-phenacetin-metabolism-test-in-the-prediction-of-postoperative-liver-dysfunction-of-patients-with-hepatocellular-carcinoma
#16
Xiaohua Pan, Xiaodong Li, Liqing Cui, Qianwei Wang
BACKGROUND The risk of postoperative liver dysfunction (PLD) in patients with injured livers, such as in hepatocellular carcinoma (HCC), is still not negligible. Phenacetin metabolism test can reflect hepatic functional reserve in patients with chronic hepatic damage. The aim of this study was to assess the ability of phenacetin metabolism test to predict PLD in patients with HCC receiving partial hepatectomy. MATERIAL AND METHODS Forty-nine patients with HCC undergoing partial hepatectomy between 2014 and 2016 were included at Huashan Hospital, Fudan University...
May 29, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28551711/why-are-most-phospholipidosis-inducers-also-herg-blockers
#17
Svetoslav Slavov, Iva Stoyanova-Slavova, Shuaizhang Li, Jinghua Zhao, Ruili Huang, Menghang Xia, Richard Beger
Recent reports have noted that a number of compounds that block the human Ether-à-go-go related gene (hERG) ion channel also induce phospholipidosis (PLD). To explore a hypothesis explaining why most PLD inducers are also hERG inhibitors, a modeling approach was undertaken with data sets comprised of 4096 compounds assayed for hERG inhibition and 5490 compounds assayed for PLD induction. To eliminate the chemical domain effect, a filtered data set of 567 compounds tested in quantitative high-throughput screening (qHTS) format for both hERG inhibition and PLD induction was constructed...
May 27, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28549792/endocannabinoids-modulate-apoptosis-in-endometriosis-and-adenomyosis
#18
Elif Bilgic, Elif Guzel Meydanli, Sevil Kose, Makbule Cisel Aydin, Eda Karaismailoglu, Irem Akar, Alp Usubutun, Petek Korkusuz
Adenomyosis that is a form of endometriosis is the growth of ectopic endometrial tissue within the muscular wall of the uterus (myometrium), which may cause dysmenorrhea and infertility. Endocannabinoid mediated apoptotic mechanisms of endometriosis and adenomyosis are not known. We hypothesized that the down regulation of endocannabinoid receptors and/or alteration in their regulatory enzymes may have a direct role in the pathogenesis of endometriosis and adenomyosis through apoptosis. Endocannabinoid receptors CB1 and CB2, their synthesizing and catabolizing enzymes (FAAH, NAPE-PLD, DAGL, MAGL) and the apoptotic indexes were immunohistochemically assessed in endometriotic and adenomyotic tissues...
May 23, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28544386/skin-mucous-membrane-disorder-and-therapeutic-effect-of-pegylated-liposomal-doxorubicin-in-recurrent-ovarian-cancer
#19
Yuki Yamada, Ryuji Kawaguchi, Fuminori Ito, Kana Iwai, Emiko Niiro, Hiroshi Shigetomi, Yasuhito Tanase, Hiroshi Kobayashi
AIM: Hand-foot syndrome (HFS) induced by chemotherapy and molecule-targeting drugs is correlated with treatment efficacy. We conducted a retrospective analysis to evaluate the relationship between HFS and efficacy of pegylated liposomal doxorubicin (PLD) for recurrent ovarian cancer. METHODS: Patients were treated with PLD between July 2009 and May 2014. We evaluated patient characteristics, incidence of adverse events, clinical benefit (rate of complete response, partial response, and stable disease), progression-free survival, and overall survival...
May 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28543567/tgr5-contributes-to-hepatic-cystogenesis-in-rodents-with-polycystic-liver-diseases-via-camp-g%C3%AE-s-signaling
#20
Tatyana V Masyuk, Anatoliy I Masyuk, Maria Lorenzo Pisarello, Brynn N Howard, Bing Q Huang, Pui-Yuen Lee, Xavier Fung, Eduard Sergienko, Robert J Ardesky, Thomas Dy Chung, Anthony B Pinkerton, Nicholas F LaRusso
Hepatic cystogenesis in Polycystic Liver Disease (PLD) is associated with increased levels of cAMP in cholangiocytes lining liver cysts. TGR5, a G protein-coupled bile acid receptor, is linked to cAMP and expressed in cholangiocytes. Therefore, we hypothesized that TGR5 might contribute to disease progression. We examined expression of TGR5 and Gα proteins in cultured cholangiocytes and in livers of animal models and humans with PLD. In vitro, we assessed cholangiocyte proliferation, cAMP levels, and cyst growth in response to: (i) TGR5 agonists [taurolithocholic acid (TLCA), oleanolic acid (OA) and two synthetic compounds]; (ii) a novel TGR5 antagonist (SBI-115); and (iii) a combination of SBI-115 and pasireotide, a somatostatin receptor (SSTR) analog...
May 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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