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https://www.readbyqxmd.com/read/29045014/efficacy-and-toxicity-of-pegylated-liposomal-doxorubicin-based-chemotherapy-in-early-stage-breast-cancer-a-multicenter-retrospective-case-control-study
#1
Fu Ou Yang, Nicholas C Hsu, Sin-Hua Moi, Yin-Che Lu, Chia-Ming Hsieh, King-Jen Chang, Dar-Ren Chen, Chi-Wen Tu, Hwei-Chung Wang, Ming-Feng Hou
AIM: PEGylated liposomal doxorubicin (PLD) has comparable efficacy and differing toxicity from conventional anthracyclines used to treat advanced breast cancer. This study compared disease-free survival and toxicity between PLD-based and conventional anthracycline-based regimens as adjuvant treatments for early-stage breast cancer. METHODS: We analyzed disease-free survival (DFS) rates, and adverse events in 102 women with early-stage (I-IIIa) breast cancer who received adjuvant PLD-based chemotherapy from 2002 to 2008...
October 18, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29038287/genetic-complexity-of-autosomal-dominant-polycystic-kidney-and-liver-diseases
#2
Emilie Cornec-Le Gall, Vicente E Torres, Peter C Harris
Data indicate significant phenotypic and genotypic overlap, plus a common pathogenesis, between two groups of inherited disorders, autosomal dominant polycystic kidney diseases (ADPKD), a significant cause of ESRD, and autosomal dominant polycystic liver diseases (ADPLD), which result in significant PLD with minimal PKD. Eight genes have been associated with ADPKD (PKD1 and PKD2), ADPLD (PRKCSH, SEC63, LRP5, ALG8, and SEC61B), or both (GANAB). Although genetics is only infrequently used for diagnosing these diseases and prognosing the associated outcomes, its value is beginning to be appreciated, and the genomics revolution promises more reliable and less expensive molecular diagnostic tools for these diseases...
October 16, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29034904/structural-magnetic-and-electronic-properties-of-pulsed-laser-deposition-grown-srfeo-sub-3-%C3%AE-sub-thin-films-and-srfeo-sub-3-%C3%AE-sub-la-sub-2-3-sub-ca-sub-1-3-sub-mno-sub-3-sub-multilayers
#3
Edith Perret, Kaushik Sen, Jarji Khmaladze, Ben Mallett, Meghdad Yazdi-Rizi, Premysl Marsik, Saikat Das, Ivan Marozau, Miguel Uribe-Laverde, Roberto de Andrés Prada, J Strempfer, Max Doebeli, Neven Biskup, Maria Varela, Yves-Laurent Mathis, Christian Bernhard
We studied the structural, magnetic and electronic properties of SrFeO<sub>3-δ</sub> (SFO) thin films and SrFeO<sub>3-δ</sub> /La<sub>2/3</sub>Ca<sub>1/3</sub>MnO<sub>3</sub> (LCMO) superlattices that have been grown with pulsed laser deposition (PLD) on La<sub>0.3</sub>Sr<sub>0.7</sub>Al<sub>0.65</sub>Ta<sub>0.35</sub>O<sub>3</sub> (LSAT) substrates. X-ray reflectometry and scanning transmission electron microscopy (STEM) confirm the high structural quality of the films and flat and atomically sharp interfaces of the superlattices...
October 16, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29034246/tolvaptan-for-the-treatment-of-enlarged-polycystic-liver-disease
#4
Hiroki Mizuno, Junichi Hoshino, Tatsuya Suwabe, Keiichi Sumida, Akinari Sekine, Yoichi Oshima, Masahiko Oguro, Kyohei Kunizawa, Masahiro Kawada, Rikako Hiramatsu, Noriko Hayami, Eiko Hasegawa, Masayuki Yamanouchi, Naoki Sawa, Kenmei Takaichi, Yoshifumi Ubara
A 44-year-old Japanese woman with autosomal dominant polycystic kidney disease was admitted to our hospital for evaluation of abdominal distension. Her eGFR was 53.7 mL/min/1.73 m(2). Total kidney volume was 2,614 mL. Tolvaptan (60 mg/day) was started to treat renal involvement. The patient's abdominal fullness began to improve and liver volume, indicating advanced polycystic liver disease (PLD), decreased from 9,750 mL to 8,345 mL after 17 months of tolvaptan treatment, though there was no significant change in kidney volume...
May 2017: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29032301/formation-of-asymmetric-vesicles-via-phospholipase-d-mediated-transphosphatidylation
#5
Rina Takaoka, Haruko Kurosaki, Hiroyuki Nakao, Keisuke Ikeda, Minoru Nakano
Most biomembranes have an asymmetric structure with regard to phospholipid distribution between the inner and outer leaflets of the lipid bilayers. Control of the asymmetric distribution plays a pivotal role in several cellular functions such as intracellular membrane fusion and cell division. The mechanism by which membrane asymmetry and its alteration function in these transformation processes is not yet clear. To understand the significance of membrane asymmetry on trafficking and metabolism of intracellular vesicular components, a system that experimentally reproduces the asymmetric nature of biomembranes is essential...
October 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29026262/personal-listening-devices-in-australia-patterns-of-use-and-levels-of-risk
#6
REVIEW
Megan Gilliver, Jenny Nguyen, Elizabeth F Beach, Caitlin Barr
Personal listening devices (PLDs) have the potential to increase the risk of noise-induced hearing loss (NIHL) for users. The present study aimed to investigate the nature and extent of the risk posed, by describing the user profile of a PLD population, identifying listening habits of that population, and examining whether PLD risk status is associated with hearing damage. A sample of 4,185 Australian PLD users completed an online survey about listening behaviors and hearing health. Listeners were characterized as low, high, or very high-risk based on daily noise dose estimates calculated from self-reported listening volume and durations...
November 2017: Seminars in Hearing
https://www.readbyqxmd.com/read/29023824/cholangiocyte-autophagy-contributes-to-hepatic-cystogenesis-in-polycystic-liver-disease-and-represents-a-potential-therapeutic-target
#7
Anatoliy I Masyuk, Tatyana V Masyuk, Maria J Lorenzo Pisarello, Jingyi Francess Ding, Lorena Loarca, Bing Q Huang, Nicholas F LaRusso
Polycystic liver disease (PLD) is a group of genetic disorders with limited treatment and significant morbidity. Hepatic cysts arise from cholangiocytes exhibiting a hyperproliferative phenotype. Considering that hyperproliferation of many cell types is associated with alterations in autophagy, we hypothesized that autophagy is altered in PLD cholangiocytes, contributes to hepatic cystogenesis, and might represent a potential therapeutic target. We employed Functional Pathway Cluster Analysis (FPCA) and NextGen Sequencing (NGS), transmission electron microscopy, immunofluorescence confocal microscopy, and western blotting to assess autophagy in human and rodent PLD cholangiocytes...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29020822/trabectedin-mechanism-of-action-and-platinum-resistance-molecular-rationale
#8
Isabelle Ray-Coquard
Trabectedin presents a complex mode of action affecting key cell biology processes in tumor cells and in the tumor microenvironment. In ovarian cancer patients with a platinum treatment-free interval of 6-12 months treated with trabectedin + pegylated liposomal doxorubicin (PLD) or single-agent PLD, and retreated with platinum after relapse, overall survival was significantly prolonged in the trabectedin + PLD group. Mechanisms by which trabectedin restores tumor sensitivity to platinum include its interaction with components of the nucleotide excision repair machinery in tumor cells and inhibition of inflammatory mediators such as IL-6 in the tumor microenvironment...
October 11, 2017: Future Oncology
https://www.readbyqxmd.com/read/29020821/when-nonplatinum-is-the-answer-the-role-of-trabectedin-plus-pegylated-liposomal-doxorubicin-in-recurrent-ovarian-cancer
#9
Nicoletta Colombo
Trabectedin + pegylated liposomal doxorubicin (PLD) offers a well tolerated and effective nonplatinum, nontaxane alternative for treatment of ovarian cancer patients with a treatment-free interval after platinum beyond 6 months, especially for those relapsing between 6 and 12 months and those who are not candidates to receive platinum-based therapy. Using the nonplatinum trabectedin + PLD combination gives patients time to recover from platinum-related toxicities and may restore platinum sensitivity in tumor cells...
October 11, 2017: Future Oncology
https://www.readbyqxmd.com/read/29018287/large-piezoelectric-strain-with-ultra-low-strain-hysteresis-in-highly-c-axis-oriented-pb-zr0-52ti0-48-o3-films-with-columnar-growth-on-amorphous-glass-substrates
#10
Minh D Nguyen, Evert P Houwman, Guus Rijnders
Thin films of PbZr0.52Ti0.48O3 (PZT) with largely detached columnar grains, deposited by pulsed laser deposition (PLD) on amorphous glass substrates covered with Ca2Nb3O10 nanosheets as growth template and using LaNiO3 electrode layers, are shown to exhibit very high unipolar piezoelectric strain and ultra-low strain hysteresis. The observed increase of the piezoelectric coefficient with increasing film thickness is attributed to the reduction of clamping, because of the increasingly less dense columnar microstructure (more separation between the grains) with across the film thickness...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992041/peripheral-tissue-levels-and-molecular-species-compositions-of-n-acyl-phosphatidylethanolamine-and-its-metabolites-in-mice-lacking-n-acyl-phosphatidylethanolamine-specific-phospholipase-d
#11
Manami Inoue, Kazuhito Tsuboi, Yoko Okamoto, Mayumi Hidaka, Toru Uyama, Toshihiko Tsutsumi, Tamotsu Tanaka, Natsuo Ueda, Akira Tokumura
N-acylethanolamines (NAEs), a class of lipid mediators, are produced from N-acyl-phosphatidylethanolamine (NAPE) by several pathways, including the direct release by NAPE-specific phospholipase D (NAPE-PLD) or the multistep pathway via sn-glycero-3-phospho-N-acylethanolamine (Gp-NAE). Using liquid chromatography-tandem mass spectrometry, we compared peripheral tissue levels of NAPE, Gp-NAE and NAE in NAPE-PLD-deficient (NAPE-PLD-/-) and wild type (WT) mice. NAPE-PLD was suggested to play a major role in the NAPE degradation in heart, kidney, and liver, but not in jejunum, because the NAPE levels except jejunum were significantly higher in NAPE-PLD-/- mice than in WT mice...
August 16, 2017: Journal of Biochemistry
https://www.readbyqxmd.com/read/28989919/the-efficacy-and-safety-of-pegylated-liposomal-doxorubicin-monotherapy-and-combination-therapy-with-carboplatin-in-korean-patients-with-recurrent-ovarian-fallopian-tube-or-primary-peritoneal-cancer-a-single-institution-experience
#12
Young-Jae Lee, Yong-Man Kim, Shin-Wha Lee, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Young-Tak Kim, Joo-Hyun Nam
OBJECTIVE: This study aimed to evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) with or without carboplatin in Korean patients with recurrent ovarian cancer (ROC), fallopian tube, or primary peritoneal cancer. METHODS: This retrospective study included 52 patients with ROC, fallopian tube, or primary peritoneal cancer who received PLD (50 mg/m(2)) between 1(st) December 2014 and 31(th) July 2016. RESULTS: The mean number of chemotherapy cycles was 3...
September 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28986032/phosphatidic-acid-producing-enzymes-regulating-the-synaptic-vesicle-cycle-role-for-pld
#13
REVIEW
Casey N Barber, Richard L Huganir, Daniel M Raben
In cortical and hippocampal neurons of the mammalian brain, the synaptic vesicle cycle is a series of steps that tightly regulate exo- and endocytosis of vesicles. Many proteins contribute to this regulation, but lipids have recently emerged as critical regulators as well. Of all the many lipid signaling molecules, phosphatidic acid is important to the physical processes of membrane fusion. Therefore, the lipid-metabolizing enzymes that produce phosphatidic acid are vital to the regulation of the cycle. Our lab is particularly interested in the potential regulatory mechanisms and neuronal roles of two phosphatidic acid-producing enzymes: diacylglycerol kinase theta (DGKθ) and phospholipase D (PLD)...
September 28, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28975480/mechanism-of-phospholipid-hydrolysis-for-oyster-crassostrea-plicatula-phospholipids-during-storage-using-shotgun-lipidomics
#14
Qinsheng Chen, Xincen Wang, Peixu Cong, Yanjun Liu, Yuming Wang, Jie Xu, Changhu Xue
A fast and efficient shotgun lipidomics strategy was applied to analyze phospholipids (PL) in the oyster Crassostrea plicatula, including 29 species of phosphatidylcholine (PtdCho), 23 species of phosphatidylethanolamine (PtdEtn), 11 species of phosphatidylserine (PtdSer), 6 species of phosphatidylinositol (PtdIns), and 17 species of lysophospholipids (Lyso-PL). During storage at 4 °C for 7 days, the PL content decreased by 68.08%, but a significant increase in the FFA content was observed (from 63.11 to 318...
October 3, 2017: Lipids
https://www.readbyqxmd.com/read/28973524/liver-cyst-gene-knockout-in-cholangiocytes-inhibits-cilium-formation-and-wnt-signaling
#15
Edgar S Wills, René H M Te Morsche, Jeroen van Reeuwijk, Nicola Horn, Iris Geomini, Liyanne F M van de Laarschot, Dorus A Mans, Marius Ueffing, Karsten Boldt, Joost P H Drenth, Ronald Roepman
Mutations in the PRKCSH, SEC63, and LRP5 genes cause autosomal dominant polycystic liver disease (ADPLD). The proteins products of PRKCSH (alias GIIB) and SEC63 function in protein quality control and processing in the endoplasmic reticulum (ER), while LRP5 is implicated in Wnt/β-catenin signaling. To identify common denominators in the PLD pathogenesis, we mapped the PLD interactome by affinity proteomics, employing both HEK293T cells and H69 cholangiocytes. Identification of known complex members, such as glucosidase IIA (GIIA) for PRKCSH, and SEC61A1 and SEC61B for SEC63, confirmed the specificity of the analysis...
August 14, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28966828/sequential-changes-of-arterial-spin-labeling-perfusion-mr-images-with-dual-postlabeling-delay-following-reconstructive-surgery-for-giant-internal-carotid-artery-aneurysm
#16
Takafumi Shimogawa, Takato Morioka, Tomoaki Akiyama, Sei Haga, Shuji Arakawa, Tetsuro Sayama
BACKGROUND: Arterial spin-labeling magnetic resonance perfusion imaging (ASL-MRI) allows noninvasive measurement of cerebral blood flow (CBF) but depends on arterial transit time (ATT). To overcome this problem, we developed a simple ASL technique with dual postlabeling delay (PLD) settings. In addition to the routinely used PLD of 1.5 seconds, we selected another PLD of 2.5 seconds to assess slowly streaming blood flow and detect arterial transit artifacts (ATAs) resulting from stagnant intravascular magnetically labeled spins...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28964725/how-mirs-and-mrna-deadenylases-could-post-transcriptionally-regulate-expression-of-tumor-promoting-protein-pld
#17
REVIEW
Julian Gomez-Cambronero, Kristen Fite, Taylor E Miller
Phospholipase D (PLD) plays a key role in both cell membrane lipid reorganization and architecture, as well as a cell signaling protein via the product of its enzymatic reaction, phosphatidic acid (PA). PLD is involved in promoting breast cancer cell growth, proliferation, and metastasis and both gene and protein expression are upregulated in breast carcinoma human samples. In spite of all this, the ultimate reason as to why PLD expression is high in cancer cells vs. their normal counterparts remains largely unknown...
August 24, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28957153/effects-of-the-zno-layer-on-the-structure-and-white-light-emission-properties-of-a-zns-mn-gan-nanocomposite-system
#18
Cai-Feng Wang, Bo Hu
ZnO films were inserted between the ZnS:Mn films and GaN substrates by pulsed laser deposition (PLD). The structure, morphology, and optical properties of the ZnS:Mn/ZnO/GaN nanocomposite systems have been investigated. X-ray diffraction results show that there are three diffraction peaks located at 28.4°, 34.4°, and 34.1°, which correspond to the β-ZnS(111), ZnO(002), and GaN(002) planes, respectively. Due to the insertion of ZnO films, the diffraction peak intensity of ZnS:Mn in ZnS:Mn/ZnO/GaN is stronger than that of ZnS:Mn in ZnS:Mn/GaN, and the full width at half-maximum is smaller...
October 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28955998/phospholipases-d%C3%AE-and-%C3%AE-are-involved-in-local-and-systemic-wound-responses-of-cotton-g-hirsutum
#19
Angeliki Bourtsala, Theodora Farmaki, Dia Galanopoulou
Phospholipases D (PLDs) catabolize structural phospholipids to produce phosphatidic acid (PtdOH), a lipid playing central role in signalling pathways in animal, yeast and plant cells. In animal cells two PLD genes have been studied while in model plant Arabidopsis twelve genes exist, classified in six classes (α-ζ). This underlines the role of these enzymes in plant responses to environmental stresses. However, information concerning the PLD involvement in the widely cultivated and economically important cotton plant responses is very limited...
March 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28953238/who-environmental-noise-guidelines-for-the-european-region-a-systematic-review-on-environmental-noise-and-permanent-hearing-loss-and-tinnitus
#20
REVIEW
Mariola Śliwińska-Kowalska, Kamil Zaborowski
Background: Hearing loss is defined as worsening of hearing acuity and is usually expressed as an increase in the hearing threshold. Tinnitus, defined as "ringing in the ear", is a common and often disturbing accompaniment of hearing loss. Hearing loss and environmental exposures to noise are increasingly recognized health problems. Objectives: The objective was to assess whether the exposure-response relationship can be established between exposures to non-occupational noise and permanent hearing outcomes such as permanent hearing loss and tinnitus...
September 27, 2017: International Journal of Environmental Research and Public Health
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